A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

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"However, as TNFalpha increased t-PA and PAI-1 in smooth muscle cells, it is suggested that other pathways and factors are involved in fibrinolysis modulation."
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"TNFalpha receptor RI was also actively released and was shown to reduce TNFalpha activity which may account for the inability of soluble TNFalpha to up-regulate PAI-1 synthesis."
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"N-acetylcysteine attenuates TNF-alpha induced changes in secretion of interleukin-6, plasminogen activator inhibitor-1 and adiponectin from 3T3-L1 adipocytes."
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"Results obtained suggest that TNF-alpha stimulates PAI-1 production by adipocytes, an effect potentiated by insulin, and that adipocyte generation of reactive oxygen centered radicals mediates the induction of PAI-1 production by TNF-alpha."
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"Additionally, sustained increased levels of proinflammatory cytokines TNF-alpha and IL-1beta can cause increased production of PAI-1 in ECs within the plaque."
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"Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation."
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"The elevated TNFalpha in the placenta may induce PAI-1 and TF, and thus promote the thrombotic alterations associated with preeclampsia."
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"TNF (100 U/ml) treatment of endothelial cultures induced steady state levels of uPA and PAI-1 mRNA following a 18 hr treatment both 6-fold and 2-fold, respectively utilizing northern analysis."
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"Therefore, it is most likely that vascular endothelial cells contribute to the increased amount of circulating PAI induced by TNF in vivo."
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"PAI-1 gene and protein expression were induced consistently by TGF-beta (up to 4.0-fold), PDGF (2.1-fold), TNF-alpha (1.7-fold), and thrombin (2.3-fold)."
TNF activates SERPINE1. 1 / 1
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bel
"The PAI-1 activity and mRNA level were increased when HUVECs were exposed to TNF-alpha or mmLDL"