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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TIAM1 activates RAC1. 10 / 487
2 | 127 332
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"Tiam1 mediated Rac activation was dependent on PI3-kinase activity both on a collagen I and fibronectin substrate, suggesting that PI3-kinase is required for Tiam1 and Rac induced cell migration as well as E-cadherin- mediated cell-cell adhesion."
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"Based on these data, Zheng and coworkers concluded that NSC23766 represents a specific inhibitor of Tiam1 mediated activation of Rac1 [XREF_BIBR, XREF_BIBR]."
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"One study implicated Tiam1 mediated Rac activation in neuronal cell polarization, whereas another study reported that a Par3 mediated inactivation of Tiam1 and Rac is required for the polarization of epithelial MDCK cells."
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"The Rac activator Tiam1 and Ras induced oncogenesis."
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"Tiam1 and P-Rex1 induce differential Rac1 downstream effects."
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"Reduction in expression of either SIP 1 or Tiam1 (via siRNA techniques) or inhibition of PI3 kinase by LY294002 inhibits S1P induced Rac1 activation, cortical actin rearrangement and endothelial barrier enhancement."
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"Transient PDGF induced as well as sustained Rac activation by Tiam1 or V12Rac downregulate Rho activity."
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"TIAM1 activates Rac1 and stimulates neuronal migration by regulating actin cytoskeleton dynamics, and JNK regulates microtubule dynamics by stimulating MAP1B phosphorylation to control neuronal migration[ xref ]."
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"Our studies identify the Rac activator Tiam1 as a critical regulator of different aspects of Ras induced tumour formation."
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"Membrane trafficking between compartments has also been suggested, for example, activation of Rac by Tiam1 on endosomes resulted in protrusive activity on the plasma membrane and cell migration. xref "
TIAM1 activates RAC1. 3 / 3
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bel
"Expression of CA-PI3K caused a significant increase in membrane-associated Tiam1 (Fig. 5B), whereas expression of DN-PI3K caused increased cytosolic Tiam1 (Fig. 5A). CS did not affect the distribution of Tiam1 when either CA-PI3K or DN-PI3K was expressed. We also found that treatment with the Tiam1 inhibitor NSC23766 caused increased cytosolic localization of Tiam1, decreased Rac1 activity, and decreased cell migration"
bel
"Phosphatidylinositol 3-kinase (PI3K) is recruited to the membrane by intact E-cadherin adhesion junctions, where it generates phosphatidylinositol-(3,4,5)- triphosphate (PIP3), resulting in the activation of the RHO-GEF TIAM1 and subsequently of RAC1 and CDC42."
bel
"Moreover, in 1321N1 astrocytoma cells, translocation of Tiam1 to the cytosol, following receptor-mediated stimulation of PtdIns(4,5)P(2) breakdown, correlates with decreased Rac1-GTP levels, indicating that membrane-association is required for GDP/GTP exchange on Rac1."
Mutated TIAM1 activates RAC1. 2 / 2
| 2
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"This defect was efficiently rescued by expressing RNAi resistant wild-type Tiam1 (XREF_FIG A) but not the GEF mutant Tiam1, which is unable to activate Rac (XREF_FIG A)."
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"We found that overexpression of the Rac1 guanine nucleotide exchange factor (GEF) Tiam1 markedly enhanced Rac1 activity, whereas a dominant negative Tiam1 mutant significantly attenuated S1P mediated Rac1 activation."
TIAM1 bound to F2RL2 activates RAC1. 1 / 1
| 1
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"PAR-3 directly interacts with Tiam1 and Taim2 (STEF), Rac1 specific guanine nucleotide exchange factors, and forms a complex with aPKC-PAR-6-Cdc42 * GTP, leading to Rac1 activation."
TIAM1 bound to 4D and Semaphorin activates RAC1. 1 / 1
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"Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma."
TIAM1 bound to BAIAP2 activates RAC1. 1 / 1
| 1
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"Tiam1, another Rac1 activator, also binds to IRSp53, leading to increased activation of Rac1 and enhanced binding of IRSp53 to both active Rac1 and WAVE2."
TIAM1 bound to NME1 activates RAC1. 1 / 1
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"It is reported that nm23-H1 bound to Tiam1 and Dbl, which activates Rac and Cdc42 small GTPase, respectively."