IndraLab

Statements

TGFB1 activates MEK. 10 / 20
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"We were therefore interested in whether TGF-beta1 also activates Raf-1 and MEK."
9038360
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"Progress in elucidating a role for high levels of FGF2 along with TGF-beta1 to stimulate the PI3K, MEK and ERK, and SMAD2/3 pathways has resulted in a third generation ' defined ' media in which KSR is replaced with BSA or human serum albumin (HSA)."
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"When control and v-ras Ha transduced MEK were treated with TGFbeta1 there was an increase Smad2, 3 and 4, increased phosphorylation of p-Smad2 that followed similar patterns of induction and decay in both cell types (XREF_FIG), and similar nuclear translocation of Smad2/3 in both normal and v-ras Ha transformed keratinocytes (XREF_FIG)."
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"In this paper we show that in cultured hepatic stellate cells TGF-beta1 induces activation of Ras, Raf-1, MEK and MAPK p42 and p44."
9038360
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"TGF-beta1 may activate both ALK5 and smad2 and MEK and ERK signaling pathways."
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"Therefore, the ability of activin A and TGFbeta1 to stimulate PI3K and AKT and MEK and ERK signaling was evaluated via western blot."
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"As for capsid expression, Ravichandran et al. ( xref ) found that TGF-β1 activated MEK1/2 and subsequent phosphorylation of Smads, which bound to or increased binding to the JCPyV promoter for VP-1 synthesis."
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"In primary T cells, TGF-beta1 activated the MEK and ERK and p38 MAP kinase pathways, but not the JNK pathway."
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"OPC derived TGF-beta1 activates the MEK and ERK pathway in cerebral endothelium via TGF-beta receptor, and the signaling cascade eventually increases the expression levels of tight-junction proteins to promote the BBB integrity."
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"Investigation of the mechanisms by which TGF-β1 stimulated LIF gene expression revealed MEK and SMAD2/3 activation by TGF-β1 mediate stimulation of LIF gene expression ( xref )."
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TGFB1 activates MEK. 1 / 1
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"ERK and p38 mediated TGF-beta suppression of osteocalcin and JunD as well as stimulation of JunB."
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