"atRA pretreatment effectively reduced fibronectin expression in glomerular mesangial cells stimulated with TGF-beta 1 or Ang II for 48 h. TGF-beta 1 stimulated PAI-1 expression reached a maximum at 5 h. atRA did n't affect the early (5 h) PAI-1 induction by TGF-beta 1, but markedly attenuated the sustained (48 h) PAI-1 induction."
"Administration of 10 -6 mol/L Ang II or 5 ng/mL TGFbeta1 for 24 h significantly induced the mRNA expression of PAI-1, Col I and FN in cultured mouse MCs when compared with medium-alone control."
"In addition, in prostate cancer cells TGF-beta1 stimulates the expression and activity of uPA, PAI-1, and MMP-9, resulting in a net increment of pericellular plasminogen activation, increased activation of MMP-9, and finally increased tumour cell invasion and metastasis [XREF_BIBR, XREF_BIBR]."
"TGF beta 1 enhanced the expression of PAI-1 but, unlike previous reports, epidermal growth factor did not have any notable effect on PAI-1 in these cells."
"Our current study demonstrated that AA significantly downregulated PAI-1 protein expression and blocked TGF-beta1 stimulated PAI-1 expression in keloid fibroblasts."
"We therefore wanted to test whether TGF-beta1 could induce PAI-1 expression in the AT84 cells, and thus inhibit uPA activity and uPAR cleavage."
"Previous reports identified that the PAI-1 expression is induced by TGF-beta1 via EGFR signaling pathway in human cancers XREF_BIBR."
"Moreover, TGF-beta1 increases PAI-1 plasma levels and promotes the epithelial-mesenchymal transition (EMT), while PAI-1 small interfering RNA prevents the TGF-beta1-induced EMT in mouse lung epithelial cells 12."
"In the present study, TGF-beta1 was shown to increase mRNA and protein levels of PAI-1 and decrease those of uPA, while APE significantly suppressed TGF-beta1-induced PAI-1 expression and increased uPA expression in the presence of TGF-beta1 in a dose dependent manner, therefore reversing the effects of TGF-beta1."
"The results showed that TGF-beta1 could induce tubular CTGF and PAI-1 mRNA expression."