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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TGFB1 increases the amount of SERPINE1. 10 / 163
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"atRA pretreatment effectively reduced fibronectin expression in glomerular mesangial cells stimulated with TGF-beta 1 or Ang II for 48 h. TGF-beta 1 stimulated PAI-1 expression reached a maximum at 5 h. atRA did n't affect the early (5 h) PAI-1 induction by TGF-beta 1, but markedly attenuated the sustained (48 h) PAI-1 induction."
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"Administration of 10 -6 mol/L Ang II or 5 ng/mL TGFbeta1 for 24 h significantly induced the mRNA expression of PAI-1, Col I and FN in cultured mouse MCs when compared with medium-alone control."
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"In addition, in prostate cancer cells TGF-beta1 stimulates the expression and activity of uPA, PAI-1, and MMP-9, resulting in a net increment of pericellular plasminogen activation, increased activation of MMP-9, and finally increased tumour cell invasion and metastasis [XREF_BIBR, XREF_BIBR]."
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"TGF beta 1 enhanced the expression of PAI-1 but, unlike previous reports, epidermal growth factor did not have any notable effect on PAI-1 in these cells."
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"Our current study demonstrated that AA significantly downregulated PAI-1 protein expression and blocked TGF-beta1 stimulated PAI-1 expression in keloid fibroblasts."
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"We therefore wanted to test whether TGF-beta1 could induce PAI-1 expression in the AT84 cells, and thus inhibit uPA activity and uPAR cleavage."
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"Previous reports identified that the PAI-1 expression is induced by TGF-beta1 via EGFR signaling pathway in human cancers XREF_BIBR."
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"Moreover, TGF-beta1 increases PAI-1 plasma levels and promotes the epithelial-mesenchymal transition (EMT), while PAI-1 small interfering RNA prevents the TGF-beta1-induced EMT in mouse lung epithelial cells 12."
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"In the present study, TGF-beta1 was shown to increase mRNA and protein levels of PAI-1 and decrease those of uPA, while APE significantly suppressed TGF-beta1-induced PAI-1 expression and increased uPA expression in the presence of TGF-beta1 in a dose dependent manner, therefore reversing the effects of TGF-beta1."
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"The results showed that TGF-beta1 could induce tubular CTGF and PAI-1 mRNA expression."
Transcriptionally active TGFB1 increases the amount of SERPINE1. 10 / 16
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biopax:ctd
No evidence text available
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Modified TGFB1 increases the amount of SERPINE1. 2 / 2
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"In the process of liver fibrogenesis, increased TGFbeta1 levels stimulate expression of PAI-1 XREF_BIBR."
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"Blocked expression of TGF-beta1 can upregulate the expression of MMP-2, 3, 7 and downregulate the expression of PAI-1 mRNA in MsC."