A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TGFB1 increases the amount of SERPINE1. 5 / 162
2 | 118
reach
"atRA pretreatment effectively reduced fibronectin expression in glomerular mesangial cells stimulated with TGF-beta 1 or Ang II for 48 h. TGF-beta 1 stimulated PAI-1 expression reached a maximum at 5 h. atRA did n't affect the early (5 h) PAI-1 induction by TGF-beta 1, but markedly attenuated the sustained (48 h) PAI-1 induction."
reach
"Administration of 10 -6 mol/L Ang II or 5 ng/mL TGFbeta1 for 24 h significantly induced the mRNA expression of PAI-1, Col I and FN in cultured mouse MCs when compared with medium-alone control."
reach
"In addition, in prostate cancer cells TGF-beta1 stimulates the expression and activity of uPA, PAI-1, and MMP-9, resulting in a net increment of pericellular plasminogen activation, increased activation of MMP-9, and finally increased tumour cell invasion and metastasis [XREF_BIBR, XREF_BIBR]."
reach
"TGF beta 1 enhanced the expression of PAI-1 but, unlike previous reports, epidermal growth factor did not have any notable effect on PAI-1 in these cells."
reach
"Our current study demonstrated that AA significantly downregulated PAI-1 protein expression and blocked TGF-beta1 stimulated PAI-1 expression in keloid fibroblasts."
Transcriptionally active TGFB1 increases the amount of SERPINE1. 10 / 16
16 |
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
Modified TGFB1 increases the amount of SERPINE1. 2 / 2
| 2
reach
"In the process of liver fibrogenesis, increased TGFbeta1 levels stimulate expression of PAI-1 XREF_BIBR."
reach
"Blocked expression of TGF-beta1 can upregulate the expression of MMP-2, 3, 7 and downregulate the expression of PAI-1 mRNA in MsC."