"atRA pretreatment effectively reduced fibronectin expression in glomerular mesangial cells stimulated with TGF-beta 1 or Ang II for 48 h. TGF-beta 1 stimulated PAI-1 expression reached a maximum at 5 h. atRA did n't affect the early (5 h) PAI-1 induction by TGF-beta 1, but markedly attenuated the sustained (48 h) PAI-1 induction."
"Administration of 10 -6 mol/L Ang II or 5 ng/mL TGFbeta1 for 24 h significantly induced the mRNA expression of PAI-1, Col I and FN in cultured mouse MCs when compared with medium-alone control."
"In addition, in prostate cancer cells TGF-beta1 stimulates the expression and activity of uPA, PAI-1, and MMP-9, resulting in a net increment of pericellular plasminogen activation, increased activation of MMP-9, and finally increased tumour cell invasion and metastasis [XREF_BIBR, XREF_BIBR]."
"TGF beta 1 enhanced the expression of PAI-1 but, unlike previous reports, epidermal growth factor did not have any notable effect on PAI-1 in these cells."
"Our current study demonstrated that AA significantly downregulated PAI-1 protein expression and blocked TGF-beta1 stimulated PAI-1 expression in keloid fibroblasts."