A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

| 1 5 99
reach
"TGFbeta1 induced PAI-1 is involved in TGFbeta1 induced gene expression."
reach
"TGFbeta1 Induced PAI-1 Contributes to a Pro Fibrotic Network in Eosinophilic Esophagitis."
reach
"SerpinE1 (PAI-1) was upregulated 6.8-fold by TGFbeta2 treatment of glaucomatous TM cells and by TGFbeta1 in HTM cells."
reach
"XREF_FIG, TGF-beta1 significantly elevated PAI-1 expression in keloid fibroblasts, while both AA (30 muM) and Ros (2 muM) suppressed the PAI-1 upregulation induced by TGF-beta1 in keloid fibroblasts, which was abrogated by GW9662 (1 muM)."
reach
"PPARgamma activation is associated with reduced expression of ECM proteins and TGF-beta1 in the glomeruli of STZ induced diabetic rats XREF_BIBR XREF_BIBR and may directly attenuate diabetic glomerular disease by inhibiting PAI-1 expression XREF_BIBR."
reach
"TGFbeta1 activates PAI-1 and PAI-1, in turn, stimulates TGFbeta1 26."
reach
"ASODN 1, 7, 8, 14, and 15, among twenty seven designed ASODNs against PAI-1 mRNA, significantly decreased PAI-1 antigen and PAI-1 activity induced by TGF-beta1 in a dose dependent manner in HUVEC in vitro."
reach
"TGF-beta 1 also caused an increase of both u-PA and PAI-1 antigens, while there was no detectable effect on t-PA."
1 |
bel
"TGF-B normally stimulates the production of the extracellular matrix by directly increasing the production of extracellular matrix proteins, including collagen and fibronectin; decreasing the production of enzymes that degrade the extracellular matrix, including collagenase,heparinase, and stromelysin; and increasing the production of proteins that inhibit enzymes that degrade the extracellular matrix, including plasminogen activator inhibitor-1 and tissue inhibitor of metalloprotease."