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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TGFB1 activates SMAD4. 8 / 59
| 4 44
reach
"We found that the gene expression levels of TGF-beta1, its receptor TGF-betaRIotaIota, and the key downstream transcription factor of TGF-beta1 signaling SMAD4 XREF_BIBR, XREF_BIBR, XREF_BIBR were similar in both uPA -/- + DSS and WT + DSS treated mice."
reach
"TGF-beta1 activated Smad3 and Smad4 signalling to facilitate their nuclear translocation."
reach
"We found that TGFbeta1 significantly increased binding of Smad4 with all three SBEs in the p15ink4b promoter, whereas TGFbeta3 significantly increased only binding with SBE B. SBE C bound most strongly with Smad4 protein."
reach
"Nuclear and cytoplasm Pitx2 and Smad4 staining was sharply increased with overexpression of Smad4, and treated with TGF-beta1 further increased the Pitx2 and Smad4 levels and induced Pitx2 and Smad4 nuclear import."
sparser
"FoxO3, a member of the Forkhead box (Fox) family, has been found to be a key partner for Smad3 and Smad4, which were activated by TGFβ1 [ xref ]."
reach
"XREF_BIBR As shown in XREF_FIG, TGF-beta1 was unable to activate the pSBE4-BV and Luc Smad4 reporter."
reach
"It has been reported recently that TGFbeta1 activated transcription factors Smad3 and Smad4 specifically interact with HNF4alpha and inhibit HNF4alpha trans-activating activity [XREF_BIBR, XREF_BIBR]."
reach
"However, addition of TGF-beta1 enhanced the interaction of Smad4 with RBPMS."
TGFB1 activates SMAD4. 6 / 6
6 |
bel
"The expression of JunD colocalised with pSmad 3 in fibrotic skin and silencing of Smad 3 or Smad 4 by siRNA prevented the induction of JunD by TGFbeta......The expression of JunD was analysed by real-time PCR, immunofluorescence, western blotting and immunohistochemistry. "
bel
"Second, silencing of SMAD protein levels using short interfering RNAs revealed that TGFbeta-induced activation of the endogenous gadd45beta gene required SMAD3 and SMAD4 but not SMAD2"
bel
"We have shown previously that the transforming growth factor-beta (TGFbeta)-regulated Sma-Mad (Smad) protein 3 and Smad4 proteins transactivate the apolipoprotein C-III promoter in hepatic cells"
bel
"Previously we have reported that the intracellular effectors of TGF-beta, Smad3 and Smad4, functionally cooperate with Sp1 to activate the human p21 promoter in hepatoma HepG2 cells."
bel
"Furthermore, expression of dominant negative Smad3 or Smad4 in cells decreased or abolished the stimulation of beta(5) promoter activity by TGF-beta. Smad4 mutant also inhibited the up-regulation of surface beta(5) level by TGF-beta. Thus, TGF-beta increases expression of the integrin beta(5) gene by mechanisms involving Sp1/Sp3 and Smad transcription factors."
bel
"activin A, TGF-beta1, and bone morphogenic protein 4 (BMP-4) bind to their respective receptor, a regulatory Smad is phosphorylated and becomes associated with Smad4, the common Smad, and the resulting complex translocates to the nucleus to regulate transcription"