IndraLab

Statements

TGFB1 phosphorylates SMAD3. 10 / 628
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"TGF-beta 1 activates Smad3 phosphorylation, which accelerates the translocation of the Smad2/3-Smad 4 heterotrimer complex to the nucleus and facilitates the transcription of TGF-beta 1 target genes 5."
28507324
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"Here, evidence is provided that Tgf-beta1, -2, -3 mRNA and phosphorylated SMAD2 and SMAD3 significantly increase as primary cultures of mouse ATII cells transdifferentiate to ATI cells."
23831617
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"To assess the effects of overexpressed recombinant endoglins on the TGF- β signaling pathway in EAhy926 cells, we analyzed the TGF- β -induced phosphorylation of Smad3."
22385575
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"ANP and cGMP inhibited TGF-beta1-induced pSmad2 and pSmad3 nuclear translocation and expression of periostin, osteopontin, and plasminogen activator inhibitor-1 mRNA and protein, but not TGF-beta1-induced phosphorylation of Smad2 and Smad3."
17038494
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"In this study, we found that DHA could reduce Akt phosphorylation at Ser473 but not S6 or Smad3 phosphorylation stimulated by TGFβ1 in NRK-49F cells, suggesting that n-3 PUFAs block mTORC2 but not mTORC1 or Smad signaling in this cell type."
28393852
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"In this study, we identified petchiether A (petA), a novel small-molecule meroterpenoid from Ganoderma, as a potential inhibitor of TGF-β1-induced Smad3 phosphorylation."
31211499
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"As shown in A, both early and late Smad3 phosphorylation induced by TGF-β1 were not inhibited by the pretreatment of HB-EGF inhibitor, CRM197."
28943431
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"Using ChIP-PCR we showed TGF-beta1 treatment induced SMAD3 protein phosphorylation in 786-O cells, and direct SMAD3 binding to the human PAX2 promoter, which was inhibited by SMAD7 over-expression."
29928489
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"TGF-beta1 binds to TGF-beta type I receptor, a transmembrane protein with Ser/Thr kinase domain, and then phosphorylates Smad2 and Smad3, which regulates the expression of downstream target genes and subsequently contributes to promoting EMT and metastasis of many cancer cells [XREF_BIBR]."
29020987
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"Furthermore, the transient overexpression of 2xFYVE, which induces the mislocalization of FYVE domain proteins, decreased the TGF-beta1-induced Smad3 phosphorylation to a similar extent to LY294002."
15153536
TGFB1 phosphorylates SMAD3 on T388. 3 / 3
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"In vitro, TGF-β1 induced phosphorylation of Smad3 T388 in a biphasic pattern."
24485922
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"The early phase of TGF-β1–induced phosphorylation of Smad3 T388 depended on the TGF-β type I receptor."
24485922
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"The kinetics of TGF-β1–induced phosphorylation of Smad3 T388 were examined in NRK49F kidney fibroblasts."
24485922
TGFB1 phosphorylates SMAD3 on S423. 2 / 2
| 2
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"Phosphorylation of Smad2 at serine 465/467 (pSmad2) and Smad3 at serine 423/425 (pSmad3) by the activated TGFbeta1 receptor modulates their activity, allowing them to translocate to the nucleus and regulate TGFbeta1 target genes XREF_BIBR, XREF_BIBR."
24075003
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"We observed that Nodal and TGFbeta1 stimulation led to Smad2 and Smad3 phosphorylation at Serine 423/425 and 465/467."
21557273
TGFB1 phosphorylates SMAD3 on S204. 2 / 2
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"TGF-β1 induced phosphorylation of SMAD-3 Ser204 was significantly decreased in GSK-3β deficient cells."
28756206
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"Indeed, TGF-β1-induced phosphorylation of SMAD-3 at Ser204 was significantly decreased in GSK-3β KO cells ( xref )."
24899689
Modified TGFB1 leads to the phosphorylation of SMAD3. 2 / 2
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"We found that overexpression of TGF-beta1 induced phosphorylation of Smad3 in NBECs and SABECs, whereas introduction of miR-744 protected against changes in the p-Smad3 level (XREF_FIG)."
30903795
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"We confirmed that TbetaRII siRNA efficiently reduced the expression of TbetaRII and TGF-beta1 induced Smad3 phosphorylation."
29888864
TGFB1 phosphorylates SMAD3 on S425. 2 / 2
| 2
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"We observed that Nodal and TGFbeta1 stimulation led to Smad2 and Smad3 phosphorylation at Serine 423/425 and 465/467."
21557273
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"Phosphorylation of Smad2 at serine 465/467 (pSmad2) and Smad3 at serine 423/425 (pSmad3) by the activated TGFbeta1 receptor modulates their activity, allowing them to translocate to the nucleus and regulate TGFbeta1 target genes XREF_BIBR, XREF_BIBR."
24075003
TGFB1 phosphorylates SMAD3 on cysteine. 1 / 1
| 1
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"Besides, in the TGF-β signaling pathway, TGF-β1 receptor kinases could phosphorylate Smad2 and Smad3 in the C terminal residue, resulting in forming a complex with Smad4, which plays the role of commo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27177473
TGFB1 leads to the phosphorylation of phosphorylated SMAD3. 1 / 1
| 1
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"Knocking down Rictor could not affect Smad3 phosphorylation induced by TGFbeta1 treatment, suggesting that the profibrotic role of Rictor in fibroblast is independent of Smad3 phosphorylation (XREF_SUPPLEMENTARY)."
25970154
TGFB1 phosphorylates SMAD3 on T179. 1 / 1
| 1
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"Similar to the kaempferol effect, treatment with AktIV resulted in selective inhibition of TGF-β1–induced phosphorylation of Smad3 at Thr179 ( xref A )."
26297431
TGFB1 leads to the phosphorylation of SMAD3 at position 467. 1 / 1
| 1
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"We observed that Nodal and TGFbeta1 stimulation led to Smad2 and Smad3 phosphorylation at Serine 423/425 and 465/467."
21557273
TGFB1 leads to the phosphorylation of SMAD3 at position 465. 1 / 1
| 1
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"We observed that Nodal and TGFbeta1 stimulation led to Smad2 and Smad3 phosphorylation at Serine 423/425 and 465/467."
21557273