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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TGFB1 phosphorylates SMAD3. 10 / 430
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"Induction of cleaved-caspase 3 and Smad3 phosphorylation by TGF-β1 were decreased in LPS co-treated cells ( xref )."
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"Smad3 phosphorylation by TGF-β1 activates p38 MAPK signaling promoting extracellular matrix production in myofibroblast [6] ."
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"CTRP3 also attenuated TGF-β1-induced Smad3 phosphorylation, nuclear translocation, and interaction with p300."
trips
"In human lung fibroblasts or bronchial smooth muscle cells, we demonstrated that an increase in the intracellular glutathione level suppressed TGF-beta1-induced phosphorylation of Smad3, while inhibiting TGF-beta1-induced expressions of CTGF, collagen type1, fibronectin and transformation into myofibroblasts, which are characterized by the expression of alpha-smooth muscle actin."
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"TGF-beta 1 activates Smad3 phosphorylation, which accelerates the translocation of the Smad2/3-Smad 4 heterotrimer complex to the nucleus and facilitates the transcription of TGF-beta 1 target genes 5."
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"Western blot analysis revealed that TGF-beta1 treatment rapidly induced phosphorylation of Smad2 and Smad3 in NRK-49F cells, and the levels of phospho-Smad2 and phospho-Smad3 reached a maximum at 30 and 60min post-treatment, respectively."
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"Transforming growth factor β-1 (TGFβ-1)-induced phosphorylation of transcription factors Smad2 and Smad3 plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF)."
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"Investigation of the effect of 4-MU4-deoxy-xyloside on TGF-beta1 phosphorylation of Smad2/3 and the expression of total Smad2/3 in lung primary fibroblasts showed that 4-MU4-deoxy-xyloside strongly attenuated the phosphorylation of Smad2 and Smad3 induced by TGF-beta1."
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"When the TβR inhibitor was added, both MUC1- and TGF-β1-induced Smad3 phosphorylation and MMP-9 expression were almost abolished, and cell migration was significantly inhibited ( Fig. 5 A–C )."
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"TGF-beta1 binds to its cell surface receptors and phosphorylates Smad 2 and Smad 3 (also known as R-Smad) which form a bond with Smad 4 (also known as co-Smad) in the cytoplasm."
TGFB1 phosphorylates SMAD3 on T388. 3 / 3
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"In vitro, TGF-β1 induced phosphorylation of Smad3 T388 in a biphasic pattern."
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"The kinetics of TGF-β1–induced phosphorylation of Smad3 T388 were examined in NRK49F kidney fibroblasts."
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"The early phase of TGF-β1–induced phosphorylation of Smad3 T388 depended on the TGF-β type I receptor."
Modified TGFB1 leads to the phosphorylation of SMAD3. 2 / 2
| 2
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"We confirmed that TbetaRII siRNA efficiently reduced the expression of TbetaRII and TGF-beta1 induced Smad3 phosphorylation."
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"We found that overexpression of TGF-beta1 induced phosphorylation of Smad3 in NBECs and SABECs, whereas introduction of miR-744 protected against changes in the p-Smad3 level (XREF_FIG)."
TGFB1 phosphorylates SMAD3 on S425. 2 / 2
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"We observed that Nodal and TGFbeta1 stimulation led to Smad2 and Smad3 phosphorylation at Serine 423/425 and 465/467."
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"Phosphorylation of Smad2 at serine 465/467 (pSmad2) and Smad3 at serine 423/425 (pSmad3) by the activated TGFbeta1 receptor modulates their activity, allowing them to translocate to the nucleus and regulate TGFbeta1 target genes XREF_BIBR, XREF_BIBR."
TGFB1 phosphorylates SMAD3 on S204. 2 / 2
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"TGF-β1 induced phosphorylation of SMAD-3 Ser204 was significantly decreased in GSK-3β deficient cells."
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"Indeed, TGF-β1-induced phosphorylation of SMAD-3 at Ser204 was significantly decreased in GSK-3β KO cells ( xref )."
TGFB1 phosphorylates SMAD3 on S423. 2 / 2
| 2
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"Phosphorylation of Smad2 at serine 465/467 (pSmad2) and Smad3 at serine 423/425 (pSmad3) by the activated TGFbeta1 receptor modulates their activity, allowing them to translocate to the nucleus and regulate TGFbeta1 target genes XREF_BIBR, XREF_BIBR."
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"We observed that Nodal and TGFbeta1 stimulation led to Smad2 and Smad3 phosphorylation at Serine 423/425 and 465/467."
TGFB1 leads to the phosphorylation of SMAD3 at position 467. 1 / 1
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"We observed that Nodal and TGFbeta1 stimulation led to Smad2 and Smad3 phosphorylation at Serine 423/425 and 465/467."
TGFB1 leads to the phosphorylation of SMAD3 at position 465. 1 / 1
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"We observed that Nodal and TGFbeta1 stimulation led to Smad2 and Smad3 phosphorylation at Serine 423/425 and 465/467."
TGFB1 phosphorylates SMAD3 on cysteine. 1 / 1
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"Besides, in the TGF-β signaling pathway, TGF-β1 receptor kinases could phosphorylate Smad2 and Smad3 in the C terminal residue, resulting in forming a complex with Smad4, which plays the role of commo[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
TGFB1 phosphorylates SMAD3 on T179. 1 / 1
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"Similar to the kaempferol effect, treatment with AktIV resulted in selective inhibition of TGF-β1–induced phosphorylation of Smad3 at Thr179 ( xref A )."
TGFB1 leads to the phosphorylation of phosphorylated SMAD3. 1 / 1
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"Knocking down Rictor could not affect Smad3 phosphorylation induced by TGFbeta1 treatment, suggesting that the profibrotic role of Rictor in fibroblast is independent of Smad3 phosphorylation (XREF_SUPPLEMENTARY)."