"Induction of cleaved-caspase 3 and Smad3 phosphorylation by TGF-β1 were decreased in LPS co-treated cells ( xref )."
"Smad3 phosphorylation by TGF-β1 activates p38 MAPK signaling promoting extracellular matrix production in myofibroblast  ."
"CTRP3 also attenuated TGF-β1-induced Smad3 phosphorylation, nuclear translocation, and interaction with p300."
"In human lung fibroblasts or bronchial smooth muscle cells, we demonstrated that an increase in the intracellular glutathione level suppressed TGF-beta1-induced phosphorylation of Smad3, while inhibiting TGF-beta1-induced expressions of CTGF, collagen type1, fibronectin and transformation into myofibroblasts, which are characterized by the expression of alpha-smooth muscle actin."
"TGF-beta 1 activates Smad3 phosphorylation, which accelerates the translocation of the Smad2/3-Smad 4 heterotrimer complex to the nucleus and facilitates the transcription of TGF-beta 1 target genes 5."
"Western blot analysis revealed that TGF-beta1 treatment rapidly induced phosphorylation of Smad2 and Smad3 in NRK-49F cells, and the levels of phospho-Smad2 and phospho-Smad3 reached a maximum at 30 and 60min post-treatment, respectively."
"Transforming growth factor β-1 (TGFβ-1)-induced phosphorylation of transcription factors Smad2 and Smad3 plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF)."
"Investigation of the effect of 4-MU4-deoxy-xyloside on TGF-beta1 phosphorylation of Smad2/3 and the expression of total Smad2/3 in lung primary fibroblasts showed that 4-MU4-deoxy-xyloside strongly attenuated the phosphorylation of Smad2 and Smad3 induced by TGF-beta1."
"When the TβR inhibitor was added, both MUC1- and TGF-β1-induced Smad3 phosphorylation and MMP-9 expression were almost abolished, and cell migration was significantly inhibited ( Fig. 5 A–C )."
"TGF-beta1 binds to its cell surface receptors and phosphorylates Smad 2 and Smad 3 (also known as R-Smad) which form a bond with Smad 4 (also known as co-Smad) in the cytoplasm."