A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TGFB1 increases the amount of SMAD2. 8 / 54
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reach
"Additionally, this study provided the first evidence that the NO donor, DEA/NO, could also induce anti-fibrotic actions via a sGC-cGMP-dependent pathway, leading to inhibition of TGF-beta1 signal transduction (at the level of pSmad2) and subsequently, the pro fibrotic influence of TGF-beta1 on renal myofibroblast differentiation, while being able to promote collagen degrading gelatinases (MMP-2 and MMP-9)."
reach
"TGF-beta1 increased the expression of NFYA, TGFbetaR1, TGFbetaR2, p-Smad2, p-Smad3, p-Smad3L, and p-Akt (Ser473), and knocking down NFYA decreased the expression of these genes, except for TGFbetaR2."
reach
"TGFbeta1 increased the mRNA level and protein expression of Smad2, 3, 7 in HSC; it also increased protein expression of collagen I and III."
reach
"As expected, the addition of exogenous TGF-beta1 increased the amount of pSMAD2 produced by BDC2.5 splenocytes, reaching its maximum level at 30-60 minutes after stimulation (data not shown)."
reach
"Our findings suggested that the expression of SOX9, COL10A1 and p-Smad2 was enhanced by TGF-beta1 stimulation in GC cells, further indicating that COL10A1 might play an important role in the TGF-beta1 and Smad2 downstream signaling pathway."
reach
"Previous in vitro studies have identified that TGF-beta1 increased expression of p-Smad2 and collagen content, and converted rat atrial fibroblasts into myofibroblasts, which induced the atrial fibrosis phenotype."
reach
"Exogenous TGF-beta1 induced temporally dependent alterations in Smad2 and Smad3 gene expression."
reach
"Our findings are partly in agreement with a report that TGF-beta1 increased Smad2 mRNA levels without affecting Smad3 mRNA expression [XREF_BIBR]."
Transcriptionally active TGFB1 increases the amount of SMAD2. 5 / 5
5 |
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
TGFB1 increases the amount of SMAD2 bound to SMAD3 and SMAD4. 2 / 2
1 1 |
bel
"In response to transforming growth factor beta (TGF-beta), Smad4 forms complexes with activated Smad2 and Smad3, which accumulate in the nucleus,"
bel
"In response to transforming growth factor beta (TGF-beta), Smad4 forms complexes with activated Smad2 and Smad3, which accumulate in the nucleus,"