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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TGFB1 activates SMAD2. 6 / 250
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"In the present study, it was observed that TGF-beta1 induced upregulation of p-SMAD2 and 3 expression, and that these changes were significantly inhibited by pretreatment with SYY."
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"Over-expressing activin receptor like kinase (ALK) 5, the TGF-beta type I receptor (TbetaRI) enhanced the up-regulation of Smad2, Smad3, MMP-9, and MMP-2 induced by TGF-beta1, whereas application of TbetaRI inhibitor SB431542 diminished the stimulatory effects of TGF-beta1 on these genes."
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"It is now well accepted that upon binding to its receptor, TGF-β1 activates two downstream proteins, Smad2 and Smad3, to exert its biological effects, which are negatively regulated by Smad7, a downstream inhibitory Smad in TGF-β signaling xref ."
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"To identify specific molecules that activate the SMAD proteins, we stimulated the mouse primary HSCs with recombinant TGF-beta1 and IL-13, respectively, and found that the TGF-beta1 activated the SMAD2 and 3 proteins while IL-13 activated all the SMAD proteins tested including SMAD1/5 (XREF_FIG)."
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"Also, TGF-beta1 activated SMAD2 and SMAD1/5, an effect that was abolished by ALK5 inhibition."
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"Studies by Ohnishi and co-workers revealed that TGF-beta1 stimulated PSC activation (indicated by increased alpha-SMA expression) in a Smad2 dependent manner, while Smad3 was required for TGF-beta1-induced growth inhibition [XREF_BIBR]."
TGFB1 activates SMAD2. 10 / 23
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bel
"Modified assertion"
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"Blocking TGF-beta1 signaling pathway by knocking down Smad2 significantly blunted the aldosterone induced fibronectin production."
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"Both SMAD2 and SMAD1/5 were activated upon exposure to TGF-beta1"
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"FIGURE 11. TGF-beta1 induces activation of Smad2/3 pathway in AML12 cell line"
bel
"TGF-beta phosphorylation of Smad2/3, an obligatory step of intracellular TGF-beta signaling, was also suppressed by VEGF. VEGF attenuation of TGF-beta action was also demonstrated in two other endothelial cell lines. In conclusion, VEGF attenuates TGF-beta action in the human endothelial cell, specifically at the level of transcription of PAI-1 gene and Smad2/3 phosphorylation"
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"In this study, we generated T cell-specific Smad2 conditional knockout (KO) mice and unexpectedly found that Smad2 and Smad3 were redundantly essential for TGF-beta-mediated induction of Foxp3-expressing regulatory T cells and suppression of IFN-gamma production in CD4(+) T cells."
bel
"By RT-PCR we have shown that TGFbeta up-regulates expression not only of plasminogen activator inhibitor type-1 (PAI-1), but also of the urokinase-type plasminogen activator receptor (uPAR), whose inhibition by specific antibodies blunted the TGFbeta angiogenic response in vitro. The SMAD2/3 and FAK signaling pathways were activated by TGFbeta in MVEC"
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"TGFb1 signaling activates receptor SMADs, SMAD2 and SMAD3, which associate with a variety of nuclear factors to regulate gene transcription"
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"In our previous studies we have shown that both Smad2 and p38 MAPK were activated in human lung fibroblasts within 10 min of TGF1 stimulation, and peak activation was reached at 1 h (19)."
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"Primary astrocytes cultured from SBE-luc mice showed specific activation of the reporter in response to Smad2/3-activating TGF-beta family members. Treatment of mice with the endotoxin LPS resulted in a fast and vigorous, but transient activation of the reporter in the intestine"
TGFB1 activates phosphorylated SMAD2. 4 / 4
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"We demonstrated that co-treatment with TGF-beta1 and CXCL9 led to a decrease in phosphorylated Smad2 and Smad3 compared to cells treated with TGF-beta1 alone."
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"Our results show that the phosphorylated SMAD2 expression pattern induced by TGF-beta1 remained the same in the two cell lines (XREF_FIG)."
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"As shown in XREF_FIG, cells pre-treated with ADC followed by TGF-beta1 treatment, the ratio of phosphorylated Smad2 and Smad3 protein is comparable to the ratio in cells treated with only TGF-beta1."
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"The expression level of the phosphorylated Smad2 (pSmad2) slightly increased when the cells were treated with 20 ng/ml TGF-beta1."
TGFB1 activates SMAD2 bound to SMAD3. 1 / 1
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bel
"In a remarkable new finding, BMP-activated Smad1 and TGF?-activated Smad2/3 bind to p68, a component of the microRNA (miRNA) processing complex DROSHA, to target the primary miR-21 transcript (primiR- 21) for miR-21 production in vascular smooth muscle cells (Davis et al., 2008). The miRNA miR-21 induces a contractile cell phenotype by downregulating the suppressor PDCD4."
TGFB1 bound to its activates SMAD2. 1 / 1
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"It is now clear that after binding to its receptors, TGF-beta1 activates its downstream signaling pathway, Smad 2 and Smad3, to mediate fibrosis, which is negatively regulated by Smad7, an inhibitor of TGF-beta signaling, via the ubiquitin-proteasome degradation mechanism XREF_BIBR, XREF_BIBR."
TGFB1 bound to TbetaRII receptor activates SMAD2. 1 / 1
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"TGF-beta1 binds to TbetaRII receptor and promotes phosphorylation of TbetaRI, and SMAD 2 and 3 proteins."