IndraLab

Statements

STK11 inhibits MTOR. 10 / 97
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"This suggested that LKB1 inhibits Yap independently of mTOR."
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"Generally , metformin inhibits mammalian Target of Rapamycin ( mTOR ) activity by activating ATM ( ataxia telangiectasia mutated ) , Liver Kinase B1 ( LKB1 ) , and then AMPK , which ultimately prevents protein synthesis and cell growth [ 6 ] ."
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"Additionally, LKB1 inhibited Yap independently of either AMPK or mTOR activation."
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"69 Loss of LKB1 leads to activation of the mTOR and IGF-1R pathways."
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"Moreover, the activation of LKB1 and AMPK stimulates autophagy through phosphorylation of ULK1 and inhibits the mTOR pathway."
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"Of interest, HeLa cells are defective in the tumor suppressor protein LKB1, also known as STK11, which inhibits mTOR by a pathway impinging on TSC2 stimulation."
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"While the inhibition of mTOR activity as well as activation by the tumor suppressor LKB1 serve as a basis for AMPK 's anti-tumor effects, induction of potentially pro survival pathways like autophagy and glucose uptake have been proposed to challenge the molecule 's anti-cancer role [XREF_BIBR]."
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"The intestinal polyps in Peutz-Jeghers syndrome have up-regulated mTORC1 signaling, supporting the idea that STK11 loss results in mTOR activation (7)."
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"Liver kinase B1 ( LKB1 , tumour suppressor ) , an upstream kinase of AMP-activated protein kinase ( AMPK ) induces AMPK phosphorylation of tuberous sclerosis complex 2 ( TSC2 ) to suppress Ras homolog enriched in brain ( Rheb ) and inhibit mTOR ."
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"The LKB1 and AMPK pathway on the other hand, inhibits mTOR and activates NF-kappaB and Notch1."
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Kinase-active STK11 inhibits MTOR. 2 / 2
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"TSC1/2 can also be targeted and activated by LKB1 tumor suppressor protein, activating the AMPdependent kinase"
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"In addition to effects on metabolism, LKB1 has also been suggested to possess a variety of potentially tumor-suppressive functions such as inhibition of mammalian target of rapamycin, regulation of cell polarity, inhibition of the cell cycle, and activation of p53 (4)."
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STK11 bound to AMPK inhibits MTOR. 1 / 1
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"Autophagy activation can also promote tumor growth via silencing of necrosis-induced inflammatory responses, with a reciprocal response seen in tumor cells evading a necrotic fate by activating the LKB1/AMPK complex, which in turn inhibits mTOR and activates downstream autophagic processes [77]."
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Mutated STK11 inhibits MTOR. 1 / 1
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"In both patients, targetable alterations of the PI3K/AKT/mTOR pathway were found, including a PIK3CA mutation itself and an STK11 mutation that negatively regulates the mTOR complex."
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