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STAT3 increases the amount of MMP9. 10 / 40
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"34 In a number of other human brain tumor cell lines, stimulation with IL-6, leukemia inhibitory factor, ciliary neurotrophic factor, or OSM induced STAT3 activation, 35 and treatment of human astrogl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The enhanced activation of STAT3 in neutrophils can promote the expression and release of MMP-9, and reduce the expression of TRAIL and the release of NE [XREF_BIBR]."
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"MMP9 is an important effector molecular in STAT3 pathway [19], and STAT3 activation can increase MMP9 expression, resulting in extracellular matrix (ECM) degradation in the tumor microenvironment [20][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has also been reported that STAT3 modulates the expression of MMP-2 and MMP-9, which help in metastasis and angiogenesis."
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"STAT3 knockdown inhibited the expression of cyclin D1, cyclin D2, cyclin D3, MMP-2, and MMP-9 in both cell lines, confirming that EtOH increases the proliferation in breast cancer cells through STAT3 activation with an increased expression of cyclins and MMPs."
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"We showed that STAT3 overexpression promoted EMT (epithelial-mesenchymal transition) with increased matrix metalloproteinase (MMP)-2 and MMP9 expression."
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"In this study, we showed that p-STAT3 directly interacts with a GAS element in MMP-9 gene promoter to drive gene expression of MMP-9."
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"Suppression of JAK2 and STAT3 pathway by AG490 attenuated the promotive effects of IL-9 on SMMC-7721 cells, and reduced the expression of VEGF, MMP-2 and MMP-9."
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"Furthermore, KYZ3 inhibited TNBC cell metastasis by decreasing the levels of MMP-9 which were directly regulated by activated STAT3."
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"In addition, STAT3 activation has been demonstrated to increase the transcription of matrix metalloproteinase-9 (MMP-9), MMP-2, focal adhesion kinase (FAK) and fascin-1, which are well-known pro-invasive factors in GBs [44]."
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Modified STAT3 increases the amount of MMP9. 3 / 3
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"A number of studies have demonstrated that the expression of activated STAT3 modulated metastasis of tumor cells by promoting gene transcription of MMP2 and MMP9."
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"Stable expression of active STAT3 increased matrix metalloproteinase MMP-9 mRNA levels in MCF-7 cells, indicating that it too is regulated by STAT3."
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"Constructive expression of STAT3 can up-regulate the expression of MMP-2 and MMP-9, which are able to efficiently degrade the extracellular matrix and basement membrane, promoting invasion and metastasis of cancer cells."
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Phosphorylated STAT3 increases the amount of MMP9. 2 / 2
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"HES1 was reported to enhance the phosphorylation of signal transducers and activators of transcription-3 (STAT3) by binding to STAT3 directly, and phosphorylated STAT3 can elevate MMP2 and MMP9 expression by directly binding to their promoters XREF_BIBR - XREF_BIBR."
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"During efficacy testing of hydrazinocurcumin (HC), a synthetic curcumin analogue, inhibition of STAT3 phosphorylation in BC cell lines (MDA-MB-231, MCF-7) decreased the expression of c-Myc, Bcl-xL, Bcl-2, Mcl-1, cyclin D1/D2, VEGF, MMP-2, and MMP-9 among others."
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Transcriptionally active STAT3 increases the amount of MMP9. 1 / 1
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"and it induces the expression of genes that are involved in invasion and metastasis, such as the matrix metalloproteinase 9 (MMP9) [29]."
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