IndraLab

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SRC phosphorylates AKT. 10 / 118
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"Therefore, this is the first study to establish a requirement for Src-dependent Akt phosphorylation in promoting, GABA B R-induced chemotaxis."
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"Tyrosine phosphorylation of Akt by Src enhances the activity of Akt."
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"Cc-ME dramatically suppressed the phosphorylation of Src and AKT induced by Src transfection in HEK293 cells in a dose dependent manner (XREF_FIG)."
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"Src inhibition leads to suppressed AKT phosphorylation in MCF7:5C cells (50)."
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"IGF-IR expression is diminished when PTEN is expressed, indicating that Src transformation leads to an increase in PI3K activation, phosphorylation of Akt, and upregulation of IGF-IR."
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"Similarly, Chandra and colleagues reported that the inhibition of Src tyrosine kinase in THP-1 cells reduced Akt phosphorylation and increased M. tb."
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"Inhibition of Src by Src inhibitors attenuated PDGF-A-stimulated phosphorylation of Akt and Dyn2 and glioma cell migration."
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"Similarly, Src kinase inhibitors, which decrease Akt phosphorylation, also counteracted the protection of mitochondrial membrane potential supporting the pivotal role of Akt in cytoprotection."
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"In addition, Src specific inhibitor PP2 caused a significant decrease in the phosphorylation of FAK, p130 (Cas), paxillin, PI3K and Akt, and ERK1/2."
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"APPL1 regulates the tyrosine phosphorylation of Akt by Src."
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SRC phosphorylates AKT on tyrosine. 10 / 24
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"In addition, YAP1 is serine phosphorylated by AKT and JNK and tyrosine phosphorylated by Yes and Src and Abl (Basu et al., 2003; Danovi et al., 2008; Levy et al., 2008; Piccolo et al., 2014; Zhao et a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, these results suggest APPL1 reduces the amount of active Akt in cells by inhibiting tyrosine phosphorylation of Akt by Src."
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"Akt tyrosine phosphorylation is mediated by the non receptor tyrosine kinase Src."
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"The PKB Y315 residue, which is known to be phosphorylated by Src tyrosine kinase, was also a major site of phosphorylation by RET and PTC."
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"Because tyrosine phosphorylation of Akt by Src was recently shown to be important in both the activation of Akt and its biological function (Chen ; Choudhury ; Bouchard ), we hypothesized that Src-mediated tyrosine phosphorylation of Akt was critical for its effects on migration."
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"We began to test this hypothesis by assessing tyrosine phosphorylation of Akt by Src in HT1080 cells."
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"Our results support a working model in which the adaptor protein APPL1 inhibits cell migration and adhesion dynamics through a mechanism involving the Src-mediated tyrosine phosphorylation of Akt."
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"Moreover, APPL1 inhibits the ability of Akt to promote migration by impairing Src mediated tyrosine phosphorylation of Akt."
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"Then Src phosphorylates Akt at Y residue(s), which triggers Akt A-loop (T308) and HM (S473) phosphorylation by PDK1 and mTORC2 xref ."
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"We began to test this hypothesis by assessing tyrosine phosphorylation of Akt by Src in HT1080 cells."
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SRC phosphorylates AKT on Y315. 9 / 9
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"We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif."
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"We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif. Furthermore, the Akt mutant lacking this proline motif fails to block the transcription activity of Forkhead in 293 cells and poorly stimulates the proliferation of Madin-Darby canine kidney cells. Taken together, our data suggest that the interaction between the SH3 domain of Src family kinases and the proline-rich motif in the C-terminal regulatory region of Akt is required for tyrosine phosphorylation of Akt and its subsequent activation."
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"Because previous work showed that the major Src phosphorylation sites in Akt, which are important in regulating its activity and function, are tyrosines 315 and 326 (Chen ), we mutated these tyrosine residues to phenylalanines."
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"Upon EGF stimulation, Akt is phosphorylated at Tyr315 and Tyr326 by Src or protein tyrosine kinase 6 (PTK6), a Src related tyrosine kinase [XREF_BIBR, XREF_BIBR]."
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"Regulation of Akt/PKB Activation by Tyrosine PhosphorylationAs shown in Fig. 2 d, while mutation of Tyr340 has little effect on either tyrosine phosphorylation or kinase activity of Akt induced by Src527F, substitution of Tyr315 or Tyr326 with a phenylalanine, respectively, dramatically reduces both the tyrosine phosphorylation and kinase activity of Akt. The combination of these two mutations abolishes Src-induced tyrosine phosphorylation of Akt as well as its kinase activity."
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"Upon EGF stimulation, Akt is phosphorylated at Tyr315 and Tyr326 by Src or protein tyrosine kinase 6 (PTK6), a Src-related tyrosine kinase [ xref , xref ]."
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"The PKB Y315 residue, which is known to be phosphorylated by Src tyrosine kinase, was also a major site of phosphorylation by RET and PTC."
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"The complex allows c-Src to phosphorylate Tyr315 and 326 residues of Akt, which are necessary for subsequent phosphorylation of Akt on thr308 and ser473 by PDK1 and PDK2, separately ( xref )."
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"We also showed that phosphorylation of Tyr 315 in Akt induced by Src or EGF is dependent on the integrity of this proline rich motif."
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Modified SRC leads to the phosphorylation of AKT. 4 / 4
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"Overexpression of Src upregulated AKT and PDK1 phosphorylation."
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"Recently we have shown that expression of kinase active Src upregulates Akt phosphorylation, accompanied by podosome formation and subsequent ECM degradation [XREF_BIBR]."
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"Increasing Src expression and activity led to increased phosphorylation of Akt, a mediator of cellular survival pathways, whereas decreasing Src activity led to decreased Akt phosphorylation."
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"Our data also demonstrate key roles for c-Src in RAGE dependent reactive oxygen species generation and signaling, as siRNA mediated reduction of c-Src expression inhibited Rac 1 activation, superoxide production and consequent AKT and GSK3beta phosphorylation."
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SRC leads to the phosphorylation of AKT on S473. 4 / 4
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"CRF 1 receptors activated by CRF can stimulate a rapid phosphorylation of Akt at Ser 473 that is mediated by upstream Src and PI-3 kinase (Olivares-Reyes & Hauger, unpublished data)."
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"Next, we investigated the roles of c-Src, NADPH oxidase, and PI3K in EGF induced Akt Ser473 phosphorylation."
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"Pretreatment with the PI3K-specific pharmacological inhibitor wortmannin blocked c-Src-induced phosphorylation of AKT S473 and expression of TGIF and MMP2/9 protein ( Fig. 7 B)."
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"Stable transfection of the Src isoform into SYF cells rescued mechanical phosphorylation of Akt Ser 473, while overexpression of Fyn failed to enhance Akt Ser 473 phosphorylation in response to strain (XREF_FIG)."
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SRC phosphorylates AKT on Y326. 3 / 3
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"Upon EGF stimulation, Akt is phosphorylated at Tyr315 and Tyr326 by Src or protein tyrosine kinase 6 (PTK6), a Src-related tyrosine kinase [ xref , xref ]."
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"Regulation of Akt/PKB Activation by Tyrosine PhosphorylationAs shown in Fig. 2 d, while mutation of Tyr340 has little effect on either tyrosine phosphorylation or kinase activity of Akt induced by Src527F, substitution of Tyr315 or Tyr326 with a phenylalanine, respectively, dramatically reduces both the tyrosine phosphorylation and kinase activity of Akt. The combination of these two mutations abolishes Src-induced tyrosine phosphorylation of Akt as well as its kinase activity."
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"Upon EGF stimulation, Akt is phosphorylated at Tyr315 and Tyr326 by Src or protein tyrosine kinase 6 (PTK6), a Src related tyrosine kinase [XREF_BIBR, XREF_BIBR]."
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Phosphorylated SRC leads to the phosphorylation of AKT. 2 / 2
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"As phosphorylation of Syk and Src is known to increase phosphorylation of IjBa and AKT (Lee et al. 2009; Byeon et al. 2012 ), we investigated the levels of p-Syk and p-Src by immunoblotting at 2, 3, and 5 min after treatment with Tf-EE.We found that Tf-EE only suppressed levels of p-Src at 3 and 5 min after LPS treatment (Figure 3(B) )."
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"As phosphorylation of Syk and Src is known to increase phosphorylation of IκBα and AKT (Lee et al. 2009; Byeon et al. 2012), we investigated the levels of p-Syk and p-Src by immunoblotting at 2, 3, and 5 min after treatment with Tf-EE."
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SRC leads to the phosphorylation of AKT on serine. 2 / 2
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"As we showed here, CRF R activated by CRF stimulated rapid phosphorylation of Akt at Ser that is mediated by upstream Src and PI3K."
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"Here, we showed that AdE4 (+), but not AdE4 (-) vectors, selectively stimulated phosphorylation of both Akt at Ser (473) and Src kinase in ECs."
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SRC phosphorylates AKT on T41. 1 / 1
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"Our data indicated that while Akt activity modulation correlated with changes in the Ser9/21 of GSK-3, changes in cSrc activity modulation using specific constitutively active and catalytically inactive mutants correlated with changes in the phosphorylation of Y216GSK-3 and Ser33/37/Thr41βcatenin, a known substrate of GSK-3, thus indicating that Src is responsible for Y216GSK-3 phosphorylation and its activation (Figure 4A and B)."
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SRC phosphorylates AKT on T308. 1 / 1
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"In initial experiments, we assessed the ability of APPL1 and Src to regulate Akt T308 phosphorylation."
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SRC phosphorylates AKT on S1177. 1 / 1
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"Akt phosphorylation activated eNOS (at Ser(1177)), and Akt also regulated the ability of Src to phosphorylate GIT1 as well as GIT1-eNOS association."
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SRC leads to the phosphorylation of AKT on S9. 1 / 1
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"Taken together, these results establish a critical role for mDia1 in transducing the effects of RAGE ligands on c-Src, Rac1 and Nox1 activation in consequent phosphorylation of AKT and GSK3beta ser 9, processes essential for RAGE ligand induced vascular SMC migration."
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SRC leads to the phosphorylation of AKT at position 473. 1 / 1
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"Here, we showed that AdE4 (+), but not AdE4 (-) vectors, selectively stimulated phosphorylation of both Akt at Ser (473) and Src kinase in ECs."
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