A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

SRC activates RAC1. 8 / 70
1 | 14 48
reach
"We demonstrate that the PI 3-kinase and Src kinase signaling pathways converge to activate Rac1 and JNK."
reach
"M-CSF signaling via Src up-regulated Rac1 activity but down-regulated Rho activity."
reach
"Src, in turn stimulates Rac via beta-pix and p130Cas-DOCK-ELMO pathways in two spatially distinct, but functionally interrelated signaling complexes involved in cell migration."
reach
"Indeed, FFA stimulated MLK activation could be mediated by a Src pathway that activates Rac and Cdc42."
reach
"Studies have shown that Src activation induces Rac1 activity and that PI3K activity is important for phagosome formation via the Fcgamma receptor."
reach
"Single substitution of Y724 to Phe abrogated Rac1 activation triggered by Src."
sparser
"Src-dependent activation of Rac1 was studied in the context of glioma tumorigenesis ( xref )."
reach
"Integrin alpha2beta1 recruitment triggered the Src kinase independent activation of the small GTPase Rac1, and activation of Rac1 was not required for PLCgamma2 phosphorylation."
SRC-Y529F activates RAC1. 3 / 3
| 3
reach
"In order to more thoroughly address the possibility that Src Y529F could be indirectly activating Rac and therefore the Arp2/3 complex, adherent A375 cells were transfected with the Rac binding domain of PAK (EGFP-Rac BD) fused to EGFP, which has been used to mark the location of active Rac in intact cells [XREF_BIBR]."
reach
"Therefore, our data support the hypothesis that Src Y529F will activate Rac and, thus, branched actin filament polymerization at or near the plasma membrane of A375 cells."
reach
"Using a Rac activity reporter, we provided direct evidence that Src Y529F activates Rac, and therefore Arp2/3 dependent branched actin polymerization."
SRC bound to PTK2 activates RAC1. 2 / 2
| 2
reach
"Antroquinonol also suppresses FAK and Src complex formation, which subsequently inhibits Rac1 and Cdc42 activation."
reach
"The active FAK and Src complex stimulates Rac1 activity through phosphorylation of a number of mediators including the scaffolding protein p130Cas, paxillin, paxillin kinase linker, Pak interacting exchange factor-beta, and spleen tyrosine kinase."
Kinase-active SRC activates RAC1. 2 / 2
2 |
bel
"We found that both Rac1 and ERK activation in HCs are downstream of active Src and protein kinase C (PKC). Treatment with specific small interfering RNA for various PKC isoforms, or with PKC isoform-specific inhibitors, demonstrated a central role for PKCepsilon in the constitutive activation of Rac1 and ERK in HCs."
bel
"Here we show that Rac1 activity is strongly elevated in Src-transformed cells and that this small G protein is a critical component of the pathway connecting oncogenic Src with cell transformation."
SRC bound to CRK and BCAR1 activates RAC1. 1 / 1
| 1
reach
"The Src, p130Cas, and Crk complex has been shown to modulate Rac activity, pseudopodium protrusion, cell migration and cancer progression [XREF_BIBR - XREF_BIBR]."
SRC bound to it activates RAC1. 1 / 1
| 1
reach
"Importantly, our current study shows that, Galpha i2 is localized in invadopodia and that it directly interacts with Src and beta-pix to activate Rac."