"For example, the phosphorylation of Y315 AKT1 (204 PKA), as well as Y326 AKT1 (215 PKA), is necessary for the activation of AKT1 by Src XREF_BIBR - XREF_BIBR."
"Src mediates protein kinase B, also known as Akt, a key factor in the regulation of cancer cell survival in the bone metastasis microenvironment."
"We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif. Furthermore, the Akt mutant lacking this proline motif fails to block the transcription activity of Forkhead in 293 cells and poorly stimulates the proliferation of Madin-Darby canine kidney cells. Taken together, our data suggest that the interaction between the SH3 domain of Src family kinases and the proline-rich motif in the C-terminal regulatory region of Akt is required for tyrosine phosphorylation of Akt and its subsequent activation."