A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

SRC activates AKT1. 3 / 21
3 | 4
reach
"For example, the phosphorylation of Y315 AKT1 (204 PKA), as well as Y326 AKT1 (215 PKA), is necessary for the activation of AKT1 by Src XREF_BIBR - XREF_BIBR."
reach
"Src mediates protein kinase B, also known as Akt, a key factor in the regulation of cancer cell survival in the bone metastasis microenvironment."
signor
"We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif. Furthermore, the Akt mutant lacking this proline motif fails to block the transcription activity of Forkhead in 293 cells and poorly stimulates the proliferation of Madin-Darby canine kidney cells. Taken together, our data suggest that the interaction between the SH3 domain of Src family kinases and the proline-rich motif in the C-terminal regulatory region of Akt is required for tyrosine phosphorylation of Akt and its subsequent activation."
Kinase-active SRC activates AKT1. 2 / 2
2 |
bel
"The downstream targets of Src that lead to the up-regulation of IGF-IR expression were previously unknown. We demonstrate here that AKT regulates IGF-IR expression in PANC-1"
bel
"Modified assertion"