A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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SRC activates EGFR. 10 / 270
5 | 1 38 208
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"Here, we show that the association of Src and TACE at the cell membrane mediates ectodomain shedding of EGFR ligands and is an important mechanism of EGFR transactivation."
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"The increase in EGFR, Src and AnxA2 levels upon Her-2 downregulation and inhibition led us to investigate the role of AnxA2 in EGFR signaling in TNBC subset of breast cancer, where EGFR plays a major role in survival, growth, migration and invasion of cancer cells XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"Several studies have shown that the Src mediated activation of EGFR plays critical roles not only in cell proliferation but also in the initiation and progression of vascular injury such as atherosclerosis."
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"These results provided evidence that guggulsterone induced ERK1/2 phosphorylation through Src mediated activation of EGFR."
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"In this context, it has been reported that Src mediated EGFR transactivation is required for Ang II induced production of TGF-beta1, 36 and sustained EGFR activation can induce arrest of epithelial cells at the G2/M phase, by which they acquire a prominent profibrotic phenotype and produce profibrotic growth factors and cytokines such as TGF-beta1."
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"There are several different mechanisms by which STAT proteins can mediate intracellular EGFR signaling, including direct activation of STATs by EGFR binding and indirect activation of STATs through Src mediated EGFR signaling."
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"This process is mediated by ligand induced EGFR activation leading to subsequent phosphorylation and activation of protein tyrosine kinases Src and FAK."
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"Accumulating evidence has shown that EGFR is a downstream signaling molecule of c-Src and c-Src could directly bind with EGFR and activate EGFR [ xref , xref , xref ]."
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"We conclude that PAR (2)-triggered PGE (2) formation in A549 cells involves a coordinated up-regulation of COX-2 and mPGES-1 involving cPLA (2), increased cytosolic Ca (2+), PKC, Src, MEK-ERK, p38 MAPK, Src mediated EGF receptor trans-activation, and also metabolic products of both COX-1 and COX-2."
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"Collectively, these results indicated that Src mediates activation of EGFR, which in turn, activates the PI3K and AKT and ERK signaling pathways in cultured mouse RPTC."
Kinase-active SRC activates EGFR. 6 / 6
4 2 |
bel
"Here, we describe that COX-2 induction is dependent on PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB signaling in HTSMCs. CSE stimulated the phosphorylation of c-Src, EGFR, PDGFR, and Akt, which were inhibited by pretreatment with the inhibitor of PKCalpha (G?6976 or G?6983), c-Src (PP1), EGFR (AG1478), PDGFR (AG1296), or PI3K (LY294002). Moreover, CSE induced a significant increase in COX-2 expression, which was reduced by pretreatment with these inhibitors or transfection with siRNA of PKCalpha, Src, or Akt."
bel
"Ang II-induced EGF-R transactivation is mediated through cSrc, a proximal target of reactive oxygen species (ROS) derived from NAD(P)H oxidase (NOX) and is dependent on AT(1)R trafficking through caveolin1 (Cav1)-enriched lipid rafts."
bel
"PTPD1 activates src tyrosine kinase and increases the magnitude and duration of epidermal growth factor (EGF) signaling. EGF receptor phosphorylation and downstream activation of ERK 1/2 and Elk1-dependent gene transcription are enhanced by PTPD1."
bel
"GRP induced Akt activation primarily through c-Src-mediated transactivation of EGFR. Transfection of dominant-negative c-Src abolished GRP-induced EGFR and Akt activation. GRP induced release of amphiregulin, and pre-incubation with human amphiregulin neutralizing antibody eliminated GRP-induced Akt phosphorylation. Pretreatment with phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 completely blocked GRP-initiated Akt phosphorylation. These results suggest that GRP stimulates Akt activation primarily via c-Src activation, followed by extracellular release of the EGFR ligand amphiregulin, leading to the activation of EGFR and PI3K."
bel
"Here, we describe that COX-2 induction is dependent on PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB signaling in HTSMCs. CSE stimulated the phosphorylation of c-Src, EGFR, PDGFR, and Akt, which were inhibited by pretreatment with the inhibitor of PKCalpha (G?6976 or G?6983), c-Src (PP1), EGFR (AG1478), PDGFR (AG1296), or PI3K (LY294002). Moreover, CSE induced a significant increase in COX-2 expression, which was reduced by pretreatment with these inhibitors or transfection with siRNA of PKCalpha, Src, or Akt. "
bel
"PTPD1 activates src tyrosine kinase and increases the magnitude and duration of epidermal growth factor (EGF) signaling. EGF receptor phosphorylation and downstream activation of ERK 1/2 and Elk1-dependent gene transcription are enhanced by PTPD1."
SRC bound to PTK2B activates EGFR. 1 / 1
| 1
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"PKC isoforms are also known to regulate MAPK and ERK through Raf-1 [XREF_BIBR] or through transactivation of the epidermal growth factor receptor (EGFR) mediated by the Src and PYK2 complex [XREF_BIBR]."
SRC activates mutated EGFR. 1 / 1
| 1
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"Similar observations have been made previously on SRC activation and inhibitor sensitivity in EGFR mutant lung cancer cell lines."
Mutated SRC activates EGFR. 1 / 1
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"A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17."
SRC bound to EGFR and MET activates EGFR. 1 / 1
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"Furthermore, we found increased EGFR binding to MET and SRC was induced by cetuximab, resulting in MET, SRC, and EGFR complex in Caco-2 cells, whereas no obvious detectable binding was observed in DiFi cells (XREF_FIG)."
SRC bound to betaArr2 activates EGFR. 1 / 1
| 1
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"Likewise, betaArr2 mediates the initiation and progression of myeloid leukemia through the activation of Wnt signaling 19, forms complex with c-Src that promotes epidermal growth factor receptor (EGFR) transactivation 20, and induces tumor cell proliferation and metastasis 21."