"In support of our data, it was reported that active c-Src can phosphorylate and potentiate Tiam1, a guanine nucleotide exchange factor (GEF) which exhibits the highest specificity for Rac1, indicating that Rac1 is mainly activated by c-Src via Tiam1 XREF_BIBR."
"Thus, these data reveal that, at initial stages of EMT, the fraction of Tiam1 associated with AJs is preferentially depleted (relative to cytoplasmic Tiam1) as a consequence of Src-induced Tiam1 phosp[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
"Tiam1 cooperated with src to induce activation of rac1 in vivo and the formation of membrane ruffles."
"Rac1 activity may be regulated by Src-dependent tyrosine phosphorylation of Vav2 and Tiam1  ."
"Src, which is also activated in focal adhesions XREF_BIBR, XREF_BIBR, can phosphorylate p130Cas, which phosphorylates and activates the Rac1 GEF DOCK180 XREF_BIBR, XREF_BIBR, or can directly phosphorylate and activate the Rac1 GEFs Vav and Tiam1 XREF_BIBR, XREF_BIBR."
"Tyrosine phosphorylation of β catenin and Tiam 1 by Src and Src/FAK complex suppresses the association of β catenin with E-cadherin and disrupts the integrity of adherens junctions, a critical step in epithelial to mesenchymal transition [ xref – xref ]."
"Src-dependent phosphorylation of Tiam1 has been recently implicated in the Rac activation induced by another barrier-protective agonist, sphingosine 1-phosphate ( Gonzalez et al., 2006 )."