IndraLab

Statements

SPARC leads to the phosphorylation of SMAD2. 7 / 7
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"In vitro recombinant SPARC increases Smad 2 phosphorylation, indicating that SPARC activates TGF-beta pathway."
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"SPARC also stimulated Smad2 phosphorylation in MB114 endothelial cells but had no effect on bone morphogenetic protein regulated Smad1 phosphorylation in either Mv1Lu or MB114 cells."
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"treatment of Mv1Lu cells with SPARC or SPARC-EC stimulated Smad2 phosphorylation"
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"It was reported that SPARC stimulated Smad2 phosphorylation and Smad2/3 nuclear translation in lung epithelial cells [ xref ]."
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"Our data indicate that SPARC modulates the TGF-beta1-dependent phosphorylation of Smad-2 in primary mesangial cells derived from wild-type and SPARC-null mice."
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"These results were concordant with experiments in vitro, which showed that addition of recombinant SPARC increased Smad2 phosphorylation at baseline as well as after stimulation with TGF-beta1 (XREF_FIG)."
19103879
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"Furthermore, Schiemann et al. [ xref ] found that SPARC-induced SMAD2 phosphorylation in endothelial and epithelial cells, an effect that was blocked with a neutralizing TGF- β antibody."
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