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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SPARC activates SMAD2. 2 / 2

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"Importantly, exogenous SPARC induced SMAD2 activation in SSc patient fibroblasts, but had no effect in fibroblasts from HC."

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"Although inhibition of SPARC expression by shRNA in fibroblasts decreased the ratio of p-Smad2 and Smad 2 following TGF-beta1 stimulation, SPARC-null versus WT infarcts did not demonstrate significant differences in Smad2 activation in vivo."

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SPARC activates SMAD2. 1 / 1

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"Finally, SPARC and SPARC-EC stimulated TGF-beta-responsive reporter gene expression through a TGF-beta receptor- and Smad2/3-dependent pathway in Mv1Lu cells"

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...