A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

BRAF activates MAPK1. 5 / 12
| 2 4
reach
"The mutations in the BRAF gene increase the kinase activity and, in turn, the constitutive stimulation of MAPK2 and MAPK3."
reach
"Pak2 and Pak4 further activate two Raf kinases, B-Raf and C-Raf, leading to ERK1 and ERK2 (ERK1/2) activation, which all seem to be necessary for EC lumen formation."
reach
"It was anticipated that expression of the truncated and constitutively activated form of BRAF would activate the ERK1 and ERK2 mitogen activated kinases (ERK1/2) so near-adjacent tissue sections to those stained for BRAF were also stained with an antibody against the phosphorylated and activated form of ERK1/2."
reach
"In this situation, markedly diminished levels of BRAF and CRAF accompanied using shRNAs, reducing ERK1 and or ERK2 levels."
sparser
"In the neuroendocrine cell lines, BON (lymph node metastasis of a pancreatic NEN) and INS-1 (a rat insulinoma cell line), over expression of Rap1 and B-Raf activated MAPK ERK-2 and ERK-dependent transcription factor Elk-1 has been noted xref ."
BRAF-V600E activates MAPK1. 1 / 4
| 1
reach
"About 50% of papillary thyroid carcinomas (PTC) harbor activating mutations in the BRAF gene (mostly BRAF V600E), an effector of MEK that in turn activates the ERK1 and ERK2 mitogen activated protein kinases."
Kinase-active BRAF activates MAPK1. 3 / 3
3 |
bel
"siRNA-mediated depletion of B-Raf reduced cell proliferation by up to 65% through the inhibition of ERK1/2 activation, irrespective of the mutational status of B-Raf."
bel
"In addition, introduction of B-Raf enhances and sustains integrin-mediated activation of ERK in wild-type primary fibroblasts"
bel
"elevated cAMP levels lead to the activation of B-Raf and hence to ERK activation"