A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

6 | 11 28
signor
"Nevertheless, s6k1-deficient mice remain sensitive to insulin owing to the apparent loss of a negative feedback loop from s6k1 to insulin receptor substrate 1 (irs1), which blunts s307 and s636/s639 phosphorylation; thus under conditions of nutrient satiation s6k1 negatively regulatesinsulin."
reach
"In vivo, 18 h of extremely high S6K1 phosphorylation [up to 80-fold] and activity [up to 4-fold] following acute resistance type contractions do not decrease total IRS-1 or -2 levels immunoprecipated from muscle lysate."
sparser
"The PI3K/AKT/mTOR signalling pathway is under the control of PTEN, but it may also be inactivated by a feedback loop in which S6K1 directly inhibits IRS1."
reach
"mTORC1 activates S6K1, which inhibits IRS-1 through phosphorylation in serine 302 42."
sparser
"S6K1 also phosphorylates and inactivates IRS1, thereby providing a negative feedback loop [ xref ]."
reach
"Further downstream, mTOR phosphorylates p70 S6 kinase (T389), a regulator of Ribosomal Protein S6 (RPS6) responsible for mRNA translation, and has been proposed to signal via 14-3-3 (tyrosine 3-monooxygenase), a required protein in Raf signaling, to inhibit IRS-1 in a negative feedback loop XREF_BIBR."
reach
"The PI3K/AKT/mTOR signalling pathway is under the control of PTEN, but it may also be inactivated by a feedback loop in which S6K1 directly inhibits IRS1."
sparser
"When mTOR is inhibited S6K1 does not inhibit IRS-1."
signor
"Turnover of the active fraction of irs1 involves raptor-mtor- and s6k1-dependent serine phosphorylation in cell culture models of tuberous sclerosiss6k1 phosphorylates irs1 in vitro on multiple residues showing strong preference for rxrxxs/t over s/t,p sites."
reach
"In culture, high levels of mTORC1 and S6K1 activity reduce IRS-1 protein and mRNA levels, diminish its function, and through serine phosphorylation targets it for proteasomal degradation."
Kinase-active RPS6KB1 inhibits IRS1. 1 / 1
1 |
bel
"S6K was shown to directly phosphorylate IRS-1 to inhibit phosphatidylinositol-3-kinase (PI3K) and Akt activation (Harrington ete al, 2004)."