A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

2 | 19 33
sparser
"In turn S6K1 phosphorylates and activates S6 ."
sparser
"S6K1 and S6K2 phosphorylate and activate the 40S ribosomal protein S6, which promotes protein synthesis through an increased rate of mRNA transcription. xref S6K1 also regulates cell size and progression through the cell cycle, xref − xref in addition to promoting cell survival by inactivating the proapoptotic protein BAD. xref "
reach
"Another important step for BDNF stimulated dendritic protein synthesis is the phosphorylation of p70S6K, which ultimately activates the ribosomal protein S6 leading to 5 '-oligopyrimidine tract containing mRNAs translation."
sparser
"p70 S6K1 is activated by two phosphorylation events: phosphorylation on Ser473 by mTOR complex 2 and on Thr308 by PDK1. xref , xref Subsequently, phosphorylated p70 S6K1 activates the ribosomal protein S6 that stimulates the translation of 5′-TOP messenger ribonucleic acids (mRNAs)."
reach
"mTORC1 controls proliferation driving the ribosomal biogenesis, phosphorylating p70S6K to activate RP-S6, and the eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1)."
reach
"Phosphorylation of p70 S6K1 further activates and phosphorylates downstream ribosomal S6 protein (rpS6), which plays a role in mRNA translation of proteins including elongation factors and ribosomal proteins."
sparser
"p70S6K phosphorylates and activates S6, a ribosomal subunit involved in initiating translation of 5′ terminal oligopyrimidine tract-containing mRNA encoding components of the protein synthesis machinery."
reach
"Phosphorylation of mTOR activates key eukaryotic translation regulators, including p70-S6 kinase (p70S6K, which directly targets ribosomal S6 protein) and the eukaryotic translation initiation factor 4-E binding protein 1 (4E-BP1)."
sparser
"In contrast, during terminal muscle differentiation, the amount of eIF3f increases as well as mTORC1, leading to an increase in S6K1 activation and phosphorylation of rpS6 and 4E-BP1 [ xref ]."
sparser
"Another important step for BDNF-stimulated dendritic protein synthesis is the phosphorylation of p70S6K, which ultimately activates the ribosomal protein S6 leading to 5’-oligopyrimidine tract-containing mRNAs translation ( xref )."
RPS6KB1-S6K activates RPS6. 3 / 3
| 3
reach
"Activation of mTOR increases phosphorylation of p70 S6K, which activates ribosomal protein S6 (rpS6), a substrate of p70 S6K."
reach
"Moreover, it is suggested that full activation of p70 S6K is dependent on the provision of amino acids to elicit a downstream activation of rpS6 [XREF_BIBR, XREF_BIBR]."
reach
"Although inhibition of p90 RSK had no effect on either P-rpS6 or P-4E-BP1, inhibition of p70 S6K selectively reduced P-rpS6."
Phosphorylated RPS6KB1 activates RPS6. 1 / 1
1 |
biopax:pid
No evidence text available
Kinase-active RPS6KB1 activates RPS6. 1 / 1
1 |
bel
"Activation of S6K1 also occurs within minutes of initiation of signalling through mTOR. S6K1 phosphorylates ribosomal protein S6, which reportedly enhances the translation of mRNA with an uninterrupted string of pyrimidine residues adjacent to the 5k-cap structure (terminal oligopyrimidine mRNA; Meyuhas, 2000). Proteins encoded by such mRNA include ribosomal proteins, translation elongation factors and poly(A) binding protein. Thus, activation of S6K1 results in a rapid increase in the synthesis of a subset of proteins."