"In summary, these studies elucidate a mechanism whereby intra-PFC BDNF binds and activates TrkB receptors, which, in turn, predominantly activates MAPK, not PI3K, signaling in PFC neurons in order to normalize cocaine mediated plasticity and suppress addictive cocaine seeking behavior."
"BDNF binds to its receptor TrkB and activates ERK1/2 and CREB."
"BDNF binds to its signaling receptor TrkB, which is abundantly expressed by adult RGCs, and activates the pro survival ERK1/2 and Akt pathways."
"XREF_BIBR BDNF bound TrkB receptors to trigger PI3K and Akt and mitogen activated protein kinase and extracellular signal regulated kinase pathways."
"In primary cerebellar granule neurons, BDNF binding to TrkB receptor triggers its movement into lipid rafts and activates ERK signaling on the pre-synaptic side, which is required for neurotransmitter release and synaptic plasticity."
"Binding of BDNF to postsynaptic TrkB induces increases in C-fiber activity and activation of PKC- and ERK- mediated signaling cascades."