A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

BDNF activates ERK. 10 / 361
| 89 265
reach
"These results indicate that VPA could regulate NMDA receptor-ERK signaling in SD rats, preventing the SD induced decrease of the expression of NR2B subunit and the activation of ERK signaling mediators such as ERK, CREB, BCL2, and BDNF."
reach
"The intracellular activation of ERK by BDNF is postulated to proceed by signaling through the BDNF receptor tropomyosin related kinase B (TrkB), as has been proposed in other systems."
reach
"CNB-001 also has BDNF like activity, and BDNF causes the activation of the ERK and Akt pathways."
sparser
"Moreover, we find that TrkB axonal transport mediated by JIP3 could regulate BDNF-induced Erk activation and axonal filopodia formation."
reach
"BDNF mediated signaling involves activation of both MAPK and Akt on the axotomized adult rat retina, and the collaboration of both MAPK and PI3K-Akt pathways seems to be necessary in neuroprotective signaling in axotomized RGCs."
reach
"A downstream factor of MECP2 is BDNF, which activates the same PI3K and MAPK pathways that are activated by IGF1 signaling."
reach
"BDNF is hypothesized to activate extracellular signal regulated kinase (ERK) by signaling through the BDNF receptor tropomyosin related kinase B (TrkB) that induces synaptic delivery of GluR1 containing AMPARs by translocation of existing receptors into the synapse."
sparser
"However, in cultured neurons, there was no apparent significant difference in the activation of MAPK by BDNF between synapsin TKO and wild-type mice ( xref , 4.61 vs 2.64, t 6 =1.92, P =0.10)."
sparser
"Several factors could underlie the temporal differences of ERK activation by CNTF and BDNF in nodose neurons."
sparser
"Furthermore, ShcD is involved in BDNF-induced MAPK activation."
BDNF activates phosphorylated ERK. 10 / 23
| 2 21
reach
"When ERK1/2 phosphorylation was analyzed we found that BDNF treatment induced a robust and similar activation (~ 140%) of p-ERK1/2 in GFP and GFP-p75 STHdh 7/7Q cells (XREF_FIG)."
reach
"BAPTA-AM suppresses p-Akt, but not p-ERK in BDNF stimulated neurons; KCl leads to p-Akt dephosphorylation and ERK phosphorylation; co-application of KCl with BDNF causes Akt dephosphorylation without affecting BDNF stimulated p-ERK."
reach
"BDNF stimulation at the RGC soma increased both p-ERK5 and p-ERK1/2 (P = 0.035 and P = 0.032, respectively; n = 6; at 48 hours)."
reach
"In Experiment 2, drug-naive rats with bilateral intra-dmPFC cannulae received an intracranial infusion of BDNF or PBS and were euthanized by rapid decapitation 0.5 hr, 2 hrs, or 6 hrs post-infusion in order to demonstrate the time course over which intradmPFC BDNF would increase p-ERK, p-CREB, and p-Akt in vivo in the dmPFC (XREF_FIG)."
reach
"XREF_BIBR Most strikingly, the BDNF induced nuclear import of pERK, which likely acts upstream of CREB, was clearly reduced in Jacob deficient neurons."
reach
"In the next set of experiments we analyzed whether exogenous BDNF application increases pERK and pCREB in the nucleus of hippocampal primary neurons of Jacob and Nsmf ko mice."
reach
"Finally, we found that rapamycin did not block BDNF induced up-regulation of p-ERK or p-Akt (XREF_FIG), despite the fact that rapamycin blocks BDNF induced phosphorylation at both Thr389 and Thr421 and Ser424 (XREF_FIG)."
reach
"Peripheral BDNF increases pERK and/or pCREB in the adult hippocampus and ventral striatum."
reach
"A marked increase of phosphorylated Erk 1/2 is observed when WT TrkB HEK293 cells are treated with BDNF and DeltaIgTrkB HEK293 cells (XREF_FIG) albeit at significantly lower levels when compared to the BDNF stimulated WT TrkB (XREF_FIG)."
reach
"Wahlin et al. found that injections of CNTF, BDNF, or FGF2 activated detectable signal transduction (pCREB, pERK, and cFOS) only in cells of the mature rodent INL [XREF_BIBR]."
BDNF bound to NTRK2 activates ERK. 6 / 6
| 6
reach
"In summary, these studies elucidate a mechanism whereby intra-PFC BDNF binds and activates TrkB receptors, which, in turn, predominantly activates MAPK, not PI3K, signaling in PFC neurons in order to normalize cocaine mediated plasticity and suppress addictive cocaine seeking behavior."
reach
"BDNF binds to its receptor TrkB and activates ERK1/2 and CREB."
reach
"BDNF binds to its signaling receptor TrkB, which is abundantly expressed by adult RGCs, and activates the pro survival ERK1/2 and Akt pathways."
reach
"XREF_BIBR BDNF bound TrkB receptors to trigger PI3K and Akt and mitogen activated protein kinase and extracellular signal regulated kinase pathways."
reach
"In primary cerebellar granule neurons, BDNF binding to TrkB receptor triggers its movement into lipid rafts and activates ERK signaling on the pre-synaptic side, which is required for neurotransmitter release and synaptic plasticity."
reach
"Binding of BDNF to postsynaptic TrkB induces increases in C-fiber activity and activation of PKC- and ERK- mediated signaling cascades."
BDNF bound to TrkB receptors activates ERK. 2 / 2
| 2
reach
"XREF_BIBR BDNF bound TrkB receptors to trigger PI3K and Akt and mitogen activated protein kinase and extracellular signal regulated kinase pathways."
reach
"In summary, these studies elucidate a mechanism whereby intra-PFC BDNF binds and activates TrkB receptors, which, in turn, predominantly activates MAPK, not PI3K, signaling in PFC neurons in order to normalize cocaine mediated plasticity and suppress addictive cocaine seeking behavior."
BDNF bound to TrkB receptor activates ERK. 1 / 1
| 1
reach
"In primary cerebellar granule neurons, BDNF binding to TrkB receptor triggers its movement into lipid rafts and activates ERK signaling on the pre-synaptic side, which is required for neurotransmitter release and synaptic plasticity."
BDNF activates ERK. 1 / 1
1 |
bel
"Moreover, the MAPK kinase inhibitor PD 098059, which inhibits MAPK activation, also markedly reduces BDNF-stimulated phosphorylation of stathmin, therefore suggesting that phosphorylation of stathmin is triggered by the activation of MAPK."
BDNF bound to trkB receptor activates ERK. 1 / 1
| 1
reach
"Mature BDNF binds specifically to the trkB receptor and activates both MAPK and PI3K pathways."
BDNF bound to FGF2 activates ERK. 1 / 1
| 1
reach
"Interestingly, FGF2 interacted with BDNF to activate Akt and ERK to offer neuroprotection [XREF_BIBR, XREF_BIBR]."
BDNF bound to trkB receptors activates ERK. 1 / 1
| 1
reach
"BDNF and NT-3 bind to trkB receptors and activate the MAPK pathway, PI3K-Akt pathway, and phospholipase C-gamma-Ca 2+ pathway."