IndraLab

Statements

RHEB activates RPS6KB1. 10 / 60
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"Overexpression of Rheb was sufficient to enhance S6K1 activity in the absence of nutrients, indicating that Rheb may be a component of the nutrient sensing machinery of mTOR."
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"Overexpression of Rab5CA was still able to inhibit amino acid stimulated mTORC1 and S6K1 in TSC2-/- MEFs, whereas cooverexpression of Myc-Rheb with Rab5CA in TSC2-/- MEFs blocked the inhibition of mTORC1 and S6K1 signaling (XREF_FIG, C and D)."
20053679
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"In contrast, Rheb overexpression drastically increased S6K1 activity when assayed in parallel."
12906785
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"We reveal that Rheb specifically activates mTOR mediated signaling rather than cell signaling through MEK and ERK and PI3K, as shown by Rheb mediated activation of S6K1 but not Akt or RSK1."
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"In many cell types, activation of mTORC1 by Rheb activates S6K1, which in turn suppresses the PI3K-Akt signaling pathway by phosphorylation and inhibition of IRS [XREF_BIBR]."
20491627
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"Amino acid withdrawal will decrease phosphorylation of the p70S6 kinase, a key mTORC1 target, but overexpression of Rheb rescues p70S6K activation (31), drawing a clear connection between mTORC1 activity and Rheb."
30237786
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"These data are consistent with the report by Garami et al, which shows that a loss-of-function mutant in TSC2 GAP domain failed to block RheB activation of S6K1 [ xref ]."
27409169
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"Moreover, Rheb does not activate a S6K1 mutant that is unresponsive to mTOR-mediated signals, confirming that Rheb functions upstream of mTOR."
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"Rheb activation of mTOR and S6K1 signaling."
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"Overexpression of the Tuberin and Hamartin heterodimer inhibits Rheb mediated S6K1 activation, suggesting that Tuberin functions as a Rheb GTPase activating protein (GAP)."
12906785
GTP-bound active RHEB activates RPS6KB1. 2 / 2
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"Rheb, a mediator of mTOR/S6K/4E-BP signaling"
12820960
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"Rheb to stimulate S6 kinase (S6K) phosphorylation"
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RHEB activates mutated RPS6KB1. 1 / 1
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"Moreover, Rheb does not activate a S6K1 mutant that is unresponsive to mTOR mediated signals, confirming that Rheb functions upstream of mTOR."
12906785
Mutated RHEB activates RPS6KB1. 1 / 1
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"Finally, we show that membrane localization of Rheb is important for its biological activity because a farnesylation defective mutant of Rheb stimulated S6K1 activation less efficiently."
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