A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

RHEB activates RPS6KB1. 7 / 25
| 9 12
reach
"However, mutation of these sites significantly inhibits Rheb induced S6K1 activation through decreased Rheb-GTP loading, suggesting that AKT regulates tuberin function by causing tuberin translocation to the cytosol, rather than by directly inhibiting its intrinsic GAP activity toward Rheb."
reach
"Overexpression of Rab5CA was still able to inhibit amino acid stimulated mTORC1 and S6K1 in TSC2-/- MEFs, whereas cooverexpression of Myc-Rheb with Rab5CA in TSC2-/- MEFs blocked the inhibition of mTORC1 and S6K1 signaling (XREF_FIG, C and D)."
reach
"Finally, coexpression of a human TSC2 cDNA harboring a disease associated point mutation in the GAP domain, failed to stimulate Rheb GTPase activity or block Rheb activation of S6K1."
reach
"In many cell types, activation of mTORC1 by Rheb activates S6K1, which in turn suppresses the PI3K-Akt signaling pathway by phosphorylation and inhibition of IRS [XREF_BIBR]."
sparser
"Rheb also activates S6K1 during amino acid insufficiency via a rapamycin-sensitive mechanism, suggesting that Rheb participates in nutrient signaling through mTOR."
sparser
"However, mutation of these sites significantly inhibits Rheb-induced S6K1 activation through decreased Rheb-GTP loading, suggesting that AKT regulates tuberin function by causing tuberin translocation to the cytosol, rather than by directly inhibiting its intrinsic GAP activity toward Rheb."
sparser
"These data are consistent with the report by Garami et al, which shows that a loss-of-function mutant in TSC2 GAP domain failed to block RheB activation of S6K1 [ xref ]."
GTP-bound active RHEB activates RPS6KB1. 2 / 2
2 |
bel
"Rheb, a mediator of mTOR/S6K/4E-BP signaling"
bel
"Rheb to stimulate S6 kinase (S6K) phosphorylation"
Mutated RHEB activates RPS6KB1. 1 / 1
| 1
reach
"Finally, we show that membrane localization of Rheb is important for its biological activity because a farnesylation defective mutant of Rheb stimulated S6K1 activation less efficiently."
RHEB activates mutated RPS6KB1. 1 / 1
| 1
reach
"Moreover, Rheb does not activate a S6K1 mutant that is unresponsive to mTOR mediated signals, confirming that Rheb functions upstream of mTOR."