IndraLab

Statements

TSC2 affects TSC2
| 16
TSC2 decreases the amount of TSC2. 10 / 14
| 14
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"A previous study in smooth muscle like cells from a patient with tuberous sclerosis showed that epigenetic regulation of the TSC2 promoter through methylation represses TSC2 expression."
27048565
reach
"We further show that Gankyrin overexpression accelerated TSC2 degradation, while knockdown in a panel of colorectal cancer (CRC) cell lines, cell line derived xenografts and CRC patient derived xenograft (PDX) tumors delayed TSC2 degradation, restored the TSC2 protein level, and inhibited mTORC1 signaling and CRC growth."
26975632
reach
"While we find that activation of N is sufficient and required for repression of TSC2 protein in EBs in vivo, our S2 studies indicate that the turnover rate of the TSC2 protein also has to be increased to achieve rapid reduction of TSC2 levels."
23144631
reach
"TSC2 RNAi significantly decreased endogenous TSC2 protein levels, but had no effect on the unrelated protein MEK2."
14651849
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"Su (H)-mediated transcriptional repression of gigas and Tsc2 was thus a plausible mechanism for N induced repression of TSC2 expression in EBs."
23144631
reach
"Inhibition of tuberin expression by Tsc2 antisense greatly reduces the ability of TGF-beta to transcriptionally regulate p21 (CIP), p27 (KIP), and cyclin A leading to an abrogation of the antiproliferative effects of TGF-beta1."
15066998
reach
"The TSC2 shRNA strongly reduced endogenous TSC2 expression in all MEFs (XREF_FIG)."
19838215
reach
"LAM and TSC cells bear a germline mutation in exon 21 of TSC2 and do not express tuberin because of an epigenetic silencing of the TSC2 second allele that confirms our previously published evidence that an epigenetic alteration of TSC2 can cause the loss of tuberin in TSC cells [XREF_BIBR]."
24606538
reach
"Moreover, transfection of TSC2 and tuberin siRNA into PC-3 cells inhibited the expression of tuberin, mildly increased the basal phosphorylation level and only marginally counteracted curcumin mediated inhibition (XREF_FIG), while showed no effect on the basal level or curcumin mediated inhibition of the phosphorylation of Akt."
18790744
reach
"First, western blotting validated that the expression of TSC2 was effectively decreased by TSC2 targeted shRNA (XREF_FIG)."
34395438
Methylated TSC2 decreases the amount of TSC2. 1 / 1
| 1
reach
"Our data show for the first time that methylation of the TSC2 promoter might cause a complete loss of tuberin in TSC2 cells, and that the pathogenesis of angiomyolipomas might also originate from epigenetic defects in smooth muscle cells."
19443708
TSC2 phosphorylated on T1462 decreases the amount of TSC2. 1 / 1
| 1
reach
"Phosphorylation of tuberin at Thr 1462 was significantly increased concomitant with significantly decreased tuberin protein expression in human RCC compared with normal adjacent tissue."
20304964
AKT affects TSC2
| 5
AKT decreases the amount of TSC2. 3 / 14
| 3
reach
"Furthermore, Akt mediated MDM2 (murine double minute-2) phosphorylation enables p53 sequestration and ubiquitination, consequently reducing the expression of TSC2, IGF binding protein-3 (prevents IGF binding to IGF-IR) and PTEN [phosphatase and tensin homolog; dephosphorylates PIP 3 (phosphatidylinositol 3,4,5-triphosphate)] [XREF_BIBR]."
22172248
reach
"As shown in Fig. 12 C, AKT -inhibitor significantly decreased the protein levels of p-AKT / AKT, p-mTOR / mTOR, BCL2, PSMD9, p-CDK1, CDK1, p-CCNB1 and CCNB1 in EECs, and increased TSC2, BAX and Caspas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29800603
reach
"In human HeLa cells, Dan et al. [36] report that while expression of constitutively active Akt had no effect on the stability of the hamartin and tuberin complex, Akt markedly decreased levels of both[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12781866
Phosphorylated AKT decreases the amount of TSC2. 1 / 1
| 1
reach
"The inhibition of p-AKT, in turn, increases the expression of p-TSC2 and down-regulates p-mTOR, which is followed by the down-regulation of phosphorylated p70S6K and 4E-BP1, to induce autophagy."
28969040
Modified AKT decreases the amount of TSC2. 1 / 1
| 1
reach
"To this end, expression of dominant negative Akt significantly increased the expression of tuberin."
20304964
MALAT1 affects TSC2
| 8
MALAT1 decreases the amount of TSC2. 7 / 7
| 7
reach
"These findings implied that MALAT1 might epigenetically repress TSC2 transcription via recruiting EZH2 to TSC2 promoter regions, and thereby induce mTOR activation and subsequent autophagy inhibition.In this study, we investigated the role of TSC2-mTOR-autophagy signaling in the MALAT1-mediated attenuation of myocardial apoptosis."
31783925
reach
"Moreover, MALAT1 overexpression recruited EZH2 to TSC2 promoter regions to elevate H3K27me3 and epigenetically inhibited TSC2 transcription."
31783925
reach
"We then investigated the mechanism whereby MALAT1 inhibited TSC2 protein level."
31783925
reach
"Furthermore, MALAT1 epigenetically repress TSC2 transcription via recruiting EZH2 to TSC2 promoter regions."
31783925
reach
"Our results showed that MALAT1 overexpression decreased protein levels of TSC2, whereas increased phosphorylation level of mTOR (p-mTOR)."
31783925
reach
"In this study, we provided first evidence that MALAT1 epigenetically repress TSC2 transcription via recruiting EZH2 to TSC2 promoter regions to induce H3K27me3, and thereby induce mTOR activation and subsequent autophagy inhibition.Autophagy can be activated as a stress response shortly after AMI; however, sustained ischemia impaired cardiomyocyte autophagy flux, which exacerbated the post-infarct adverse cardiac modeling [27]."
31783925
reach
"Furthermore, we elucidated whether MALAT1 epigenetically repress TSC2 transcription via recruiting EZH2 to TSC2 promoter regions."
31783925
Modified MALAT1 decreases the amount of TSC2. 1 / 1
| 1
reach
"Moreover, MALAT1 overexpression recruited EZH2 to TSC2 promoter regions to elevate H3K27me3 and epigenetically inhibited TSC2 transcription."
31783925
TSC2 is modified
| 5 2
TSC2 is degraded. 7 / 7
| 5 2
trips
"Binding with HPV16 E6 causes the proteasome-mediated degradation of Tuberin."
15175323
reach
"In addition, SCs transfected with the miR-1764 agomir led to an improvement of proliferation capacity through down-regulating AMPKα2 level, which further decreased TSC2 expression and induced mTOR activation."
34481229
trips
"Taken together, degradation of TSC2 is mediated by E6AP ubiquitin ligase."
18298802
trips
"FBXW5 is a TSC2 binding receptor within CUL4 E3 ligase complex, and it promotes proteasomal degradation of TSC2."
24372178
reach
"DP effectively inhibited the phosphorylation of PI3K and its downstream factors p-Akt and p-mTOR, oppositely enhanced the expression of TSC1 (hamartin) and TSC2 (tuberin), which could be reversed by the co-treatment with the PI3K inhibitor wortmannin."
26239613
trips
"In the present study, we investigated the role of E6-associated protein (E6AP) in HPV16 E6-induced TSC2 degradation."
18298802
trips
"We previously found that HPV16 E6 causes the degradation of the tumor suppressor protein TSC2, resulting in the phosphorylation of S6 kinase and S6 even in the absence of insulin."
18298802
CUL4B affects TSC2
| 5
Modified CUL4B decreases the amount of TSC2. 4 / 4
| 4
reach
"On the other hand, XLMR mutant (R388X), (R572C) or (V745A) CUL4B overexpressed in 293 cells failed to significantly decrease the protein level of TSC2."
23348097
reach
"In contrast, XLMR mutant (R388X), (R572C) or (V745A) CUL4B stably expressed in HEK 293 cells did not downregulate the protein expression of TSC2 or cyclin E."
23348097
reach
"In contrast to wild-type CUL4B, overexpression of XLID mutant (R388X), (R572C) or (V745A) CUL4B failed to downregulate protein expression of TSC2 or cyclin E in cultured neocortical neurons."
23348097
reach
"shRNA mediated knockdown of CUL4B protein level greatly upregulated protein expression of cyclin E or TSC2 in cultured neocortical neurons.Knockdown of CUL4B induced upregulation of TSC2 in neocortica[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23348097
CUL4B decreases the amount of TSC2. 1 / 1
| 1
reach
"Furthermore, shRNA mediated CUL4B knockdown caused an upregulation of TSC2 or cyclin E. XLID mutant (R388X), (R572C) or (V745A) CUL4B did not downregulate protein expression of TSC2 or cyclin E in neocortical neurons."
23348097
TP53 affects TSC2
| 3
TP53 decreases the amount of TSC2. 2 / 2
| 2
reach
"Reciprocally, p53 negatively regulates cell growth by activating expression of Pten, TSC2, and AMPKbeta."
25486431
reach
"Several key components of the mTOR pathway are, in fact, down-regulated by p53 [XREF_BIBR] and, consistent with this idea, the Blagosklonny and Gudkov labs showed, in a subsequent publication [XREF_BIBR], that silencing the expression of TSC2, an upstream inhibitor of mTORC1 that is induced by p53, partially changed Nutlin 3a induced quiescence into senescence."
| PMC
Modified mutated TP53 decreases the amount of TSC2. 1 / 1
| 1
reach
"Mechanistically, it was determined that loss or mutation of p53 decreased expression of TSC2 and Sestrin2 (SESN2)."
26385560
PSMD10 affects TSC2
| 3
PSMD10 decreases the amount of TSC2. 2 / 2
| 2
reach
"Gankyrin knockdown dramatically increased TSC2 protein levels while decreasing mTORC1 signaling (P-S6K1)."
26975632
reach
"Furthermore, gankyrin knockdown inhibited oncogenic growth (growth curve and Ki67 staining) of DLD1, HCT116 and SW480 xenograft tumors in nude mice, and restored TSC2 expression while attenuating mTOR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26975632
Modified PSMD10 decreases the amount of TSC2. 1 / 1
| 1
reach
"As expected, gankyrin overexpression dramatically decreased TSC2 protein levels while inducing the activation of mTORC1."
26975632
MYC affects TSC2
2 | 1
MYC decreases the amount of TSC2. 3 / 3
2 | 1
biopax:pid
No evidence text available
18056446
biopax:msigdb
No evidence text available
reach
"C-MYC also downregulates the expression of TSC2, a negative regulator of mTOR, to maintain a feed-forward signaling loop [XREF_BIBR]."
26046375
AKT3 affects TSC2
| 3
Modified AKT3 decreases the amount of TSC2. 3 / 3
| 3
reach
"Overexpression of AKT3 also increased protein abundance of phospho-AKT S473, phospho-AKT T308, and B-Raf but decreased expression of TSC1 and TSC2 proteins in LNCaP, DU-145, and CA-HPV-10 PCa cells."
26318033
reach
"Overexpression of AKT3 proteins decreased protein expression of TSC1 and TSC2 but increased protein abundance of phospho-AKT Ser473, phospho-AKT Thr308, and B-Raf in PC-3, DU-145, CA-HPV, and LNCaP PCa cells."
26318033
reach
"As overexpression of AKT3 decreased protein level of TSC1 and TSC2, we hypothesized that knockdown of TSC1 or TSC2 will enhance proliferation of prostate cancer cells."
26318033
Sirolimus affects TSC2
1 | 1
Sirolimus decreases the amount of TSC2. 2 / 2
1 | 1
reach
"Rapamycin treatment significantly reduced p-TSC2 levels in AS and WT mice, but did not alter total TSC2 levels (XREF_TABLE, XREF_SUPPLEMENTARY)."
27173058
ctd
No evidence text available
31676321
ShTSC2 affects TSC2
| 2
ShTSC2 decreases the amount of TSC2. 2 / 2
| 2
reach
"shRNA against the C terminus of TSC2 (shTSC2) was shown to strongly reduce the level of TSC2."
20478529
reach
"ShTSC2 significantly reduced TSC2 levels in these different cancer cells (XREF_SUPPLEMENTARY)."
20478529
Paracetamol affects TSC2
2 |
Paracetamol decreases the amount of TSC2. 2 / 2
2 |
ctd
No evidence text available
26690555
ctd
No evidence text available
21420995
P-chloromercuribenzoic acid decreases the amount of TSC2. 2 / 2
2 |
ctd
No evidence text available
27188386
ctd
No evidence text available
26272509
Bisphenol A affects TSC2
2 |
Bisphenol A decreases the amount of TSC2. 2 / 2
2 |
ctd
No evidence text available
21890461
ctd
No evidence text available
27539358
TSC1 affects TSC2
| 2
TSC1 decreases the amount of TSC2. 2 / 2
| 2
reach
"The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination."
11175345
reach
"Also in this case, TSC1 down-regulation reduced TSC2 levels and AKT/FoxO1/3 phosphorylation (XREF_SUPPLEMENTARY)."
24633152
Notch affects TSC2
| 2
Notch decreases the amount of TSC2. 2 / 2
| 2
reach
"Notch mediated suppression of TSC2 expression in ISCs and EBs."
23144631
reach
"Notch also suppresses TSC2 expression and regulates cell differentiation in the Drosophila intestinal stem cell lineage."
25654764
MECP2 affects TSC2
| 1
MECP2 decreases the amount of TSC2. 1 / 2
| 1
reach
"We found that expression of TSC1 and TSC2 can be repressed by MeCP2, which regulates HELF cell differentiation and proliferation as myofibroblasts and lead to PF ultimately."
28041914
Leu-Ile affects TSC2
| 2
Leu-Ile decreases the amount of TSC2. 2 / 2
| 2
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"Compared to the control group, the mRNA expression of GSK-3beta and TSC2 in the ZF4 cells was significantly decreased by 1, 5, and 10 mmol/L Li + treatments."
29291576
reach
"In addition, the mRNA expression of TSC2 was significantly inhibited by 25 and 50 mg/L Li + treatments."
29291576
HDAC affects TSC2
| 2
HDAC decreases the amount of TSC2. 2 / 2
| 2
reach
"This report is a first step at defining underlying events, uncovering a mechanism of HDAC dependent repression of TSC2 expression, resulting in the release of active mTOR."
27048565
reach
"Class I HDAC inhibition in the heart was shown to promote expression of tuberous sclerosis complex 2 (TSC2), which is an inhibitor of pro hypertrophic mechanistic target of rapamycin (mTOR) kinase signaling [XREF_BIBR]."
28886967
HDAC inhibitors affects TSC2
| 2
HDAC inhibitors decreases the amount of TSC2. 2 / 2
| 2
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"HDAC inhibitors upregulate the expression of tuberous sclerosis complex 2 (TSC2), an mTORC1 inhibitor."
30099761
reach
"To further explore potential mechanisms by which HDAC inhibitors promote TSC2 expression, we tested the acetylation of the TSC2 promoter with chromatin immunoprecipitation studies."
27048565
BDNF affects TSC2
| 2
BDNF decreases the amount of TSC2. 2 / 2
| 2
reach
"Although total levels of tuberin were reduced by BDNF and CX614 treatment, we found a slight increase in tuberin phosphorylation in BDNF- and CX614 stimulated hippocampal slices."
23467348
reach
"BDNF treatment rapidly reduced levels of hamartin and tuberin, negative regulators of mTOR, in a calpain dependent manner."
23467348
AMPK affects TSC2
| 1
AMPK decreases the amount of TSC2. 1 / 2
| 1
reach
"AMPK suppresses tumor survival through inhibition of mTOR by increasing the expression of p-TSC2, a tumor suppressor gene [XREF_BIBR], and leads to the inactivation of AKT and lipopolysaccharide (LPS)-induced IL-6/JAK2/STAT3 signaling in triple negative breast cancer (TNBC) [XREF_BIBR]."
31952344
Tungsten affects TSC2
1 |
Tungsten decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
30912803
Sodium arsenite affects TSC2
1 |
Sodium arsenite decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
12760830
Recombinase affects TSC2
| 1
Recombinase decreases the amount of TSC2. 1 / 1
| 1
reach
"There was significant reduction in expression of tuberin by 54% (P < 0.05) and significant increase of pS6 by 76% (P < 0.05) in animals injected with AAV1-Cre, confirming that the Cre recombinase mediates loss of tuberin and activation of mTOR in the treated mice (XREF_FIG)."
| PMC
Quercetin affects TSC2
| 1
Quercetin decreases the amount of TSC2. 1 / 1
| 1
reach
"In addition, quercetin suppressed RHEB, p-mTOR, p-YLK1 and P62 expressions but promoted TSC2 and LC3BII expressions in KOA rats."
35093450
PcDNA3.1-KISS1 affects TSC2
| 1
PcDNA3.1-KISS1 decreases the amount of TSC2. 1 / 1
| 1
reach
"Compared to the control group, we found pcDNA3.1-KISS1 could significantly increase the mRNA expression levels of PIK3CG, PIK3C1 and PDK1 (XREF_FIG B), but pcDNA3.1-KISS1 significantly decreased the mRNA expression levels of FOXO3, TSC2 and BAD (XREF_FIG C)."
30759773
PLKO.1-TSC2 affects TSC2
| 1
PLKO.1-TSC2 decreases the amount of TSC2. 1 / 1
| 1
reach
"Consistently, pLKO.1-TSC2 transfection effectively reduced TSC2 protein expression to 0.32-fold (p < 0.01), compared with control pLKO.1 cells (Figure 5D)."
28387735
Methylmercury chloride decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
28001369
Metformin affects TSC2
| 1
Metformin decreases the amount of TSC2. 1 / 1
| 1
reach
"Western blotting analysis reveals that metformin inhibits the levels of phosphorylated mTOR and its downstream effectors : phosphorylated 4E-BP1 and p70S6K via up-regulation of phosphorylated AMPK alpha and TSC2 expression in bladder tissues (XREF_FIG)."
26921394
Mercury dibromide affects TSC2
1 |
Mercury dibromide decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
27188386
MTORC1 affects TSC2
| 1
MTORC1 decreases the amount of TSC2. 1 / 1
| 1
reach
"However, DETA NONOate could further reduce EGFP-LC3 vesicles in AAA Myc-Bcl-2 expressing Tsc2 +/+ MEFs, but not in Tsc2 -/- MEFs, suggesting that the autophagy inhibition caused by NO was mediated predominantly (or maybe entirely) by the JNK1-Bcl-2 and mTORC1 pathways (XREF_FIG E)."
21726807
Hydroperoxide affects TSC2
1 |
Hydroperoxide decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
12419474
Hsa-miR-744-5p affects TSC2
1 |
Hsa-miR-744-5p decreases the amount of TSC2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-296-3p affects TSC2
1 |
Hsa-miR-296-3p decreases the amount of TSC2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-17-5p affects TSC2
1 |
Hsa-miR-17-5p decreases the amount of TSC2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Doxorubicin affects TSC2
1 |
Doxorubicin decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
29803840
Dorsomorphin affects TSC2
1 |
Dorsomorphin decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
27188386
Dextran sulfate affects TSC2
1 |
Dextran sulfate decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
31676321
Dexamethasone affects TSC2
| 1
Dexamethasone decreases the amount of TSC2. 1 / 1
| 1
reach
"Interestingly, long-term activation of monocytes with lipopolysaccharide enhanced the expression of TSC2, the principle negative regulator of mTOR, whereas dexamethasone blocked TSC2 expression and reestablished mTOR activation."
21368289
Coumestrol affects TSC2
1 |
Coumestrol decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
19167446
Cisplatin affects TSC2
1 |
Cisplatin decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
25450742
Calcium(2+) affects TSC2
| 1
Calcium(2+) decreases the amount of TSC2. 1 / 1
| 1
reach
"Treatment either with calpain-1 or -2 in the presence of calcium reduced the levels of both hamartin and tuberin in P2 membranes."
23467348
Cadmium dichloride affects TSC2
1 |
Cadmium dichloride decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
12160620
Alpinetin affects TSC2
1 |
Alpinetin decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
31676321
XLID mutant affects TSC2
| 1
Modified XLID mutant decreases the amount of TSC2. 1 / 1
| 1
reach
"In contrast to wild-type CUL4B, overexpression of XLID mutant (R388X), (R572C) or (V745A) CUL4B failed to downregulate protein expression of TSC2 or cyclin E in cultured neocortical neurons."
23348097
U0126 affects TSC2
| 1
U0126 decreases the amount of TSC2. 1 / 1
| 1
reach
"Western blot and immunofluorescence analyses showed that U0126 significantly decreased the phosphorylation levels of Tsc2, S6K1, and rpS6 and the expression of KITL, indicating that U0126 inhibits mTORC1-KITL signaling."
28218391
TWIST1 affects TSC2
| 1
TWIST1 decreases the amount of TSC2. 1 / 1
| 1
reach
"In addition, SCs transfected with the miR-1764 agomir led to an improvement of proliferation capacity through down-regulating AMPKα2 level, which further decreased TSC2 expression and induced mTOR activation."
34481229
TSC2-AS affects TSC2
| 1
TSC2-AS decreases the amount of TSC2. 1 / 1
| 1
reach
"In contrast, suppression of tuberin expression by TSC2-AS treatment in PC12h cells significantly inhibited neuronal differentiation after NGF stimulation."
17376623
TRIM6 affects TSC2
| 1
TRIM6 decreases the amount of TSC2. 1 / 1
| 1
reach
"According to our results, TRIM6 overexpression downregulated the protein levels of TSC1 and TSC2 while the TRIM6 shRNA recovered their cellular levels."
33634104
TGFB1 affects TSC2
| 1
TGFB1 decreases the amount of TSC2. 1 / 1
| 1
reach
"Furthermore, we found that reduced expression of TSC1 and TSC2 caused by TGF-beta1 is associated with the promoter methylation status of TSC1 and TSC2."
28041914
STAT3 affects TSC2
| 1
STAT3 decreases the amount of TSC2. 1 / 1
| 1
reach
"These results demonstrate that STAT3 downregulates COX2 expression downstream of TSC2 and mTORC1 in Tsc2-null cells."
27078846
R388X affects TSC2
| 1
R388X decreases the amount of TSC2. 1 / 1
| 1
reach
"Furthermore, shRNA mediated CUL4B knockdown caused an upregulation of TSC2 or cyclin E. XLID mutant (R388X), (R572C) or (V745A) CUL4B did not downregulate protein expression of TSC2 or cyclin E in neocortical neurons."
23348097
PTEN affects TSC2
| 1
PTEN decreases the amount of TSC2. 1 / 1
| 1
reach
"Furthermore, Akt mediated MDM2 (murine double minute-2) phosphorylation enables p53 sequestration and ubiquitination, consequently reducing the expression of TSC2, IGF binding protein-3 (prevents IGF binding to IGF-IR) and PTEN [phosphatase and tensin homolog; dephosphorylates PIP 3 (phosphatidylinositol 3,4,5-triphosphate)] [XREF_BIBR]."
22172248
PPP1R3A affects TSC2
| 1
PPP1R3A decreases the amount of TSC2. 1 / 1
| 1
reach
"Rg1 significantly increased SA-beta-Gal and reduced CFU-Mix formation compared with the control group (p < 0.05), significantly down-regulated SIRT1 expression in CD34+ CD38- KG1alpha LSCs compared with the control group (p < 0.05), and significantly reduced TSC2 expression in CD34+ CD38- KG1alpha LSCs compared with the control group (p < 0.05)."
32037392
PI3K affects TSC2
| 1
Phosphorylated PI3K decreases the amount of TSC2. 1 / 1
| 1
reach
"DP effectively inhibited the phosphorylation of PI3K and its downstream factors p-Akt and p-mTOR, oppositely enhanced the expression of TSC1 (hamartin) and TSC2 (tuberin), which could be reversed by the co-treatment with the PI3K inhibitor wortmannin."
26239613
PEX5 affects TSC2
| 1
PEX5 decreases the amount of TSC2. 1 / 1
| 1
reach
"Based on our data, PEX5 depletion repressed the transcriptional expression of TSC2 during starvation, which in turn was unable to inhibit mTOR activation, thereby blocking the autophagy process even in serum depleted conditions."
29622767
Nonylphenol affects TSC2
1 |
Nonylphenol decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
29641977
NOTCH1 affects TSC2
| 1
Modified NOTCH1 decreases the amount of TSC2. 1 / 1
| 1
reach
"Three pieces of evidence indicate that transcriptional repression of TSC2 occurs downstream of N activation in the ISC lineage : (i) TSC2 expression is significantly reduced in EBs with high levels of N signaling activity, (ii) forced expression of N ICD suppresses TSC2 expression in ISCs, and (iii) loss of TSC2 is sufficient to rescue N loss of function phenotypes in the ISC lineage."
23144631
MEK affects TSC2
| 1
MEK decreases the amount of TSC2. 1 / 1
| 1
reach
"The experimental data indicated that MEK inhibition increased p-AKT and p-TSC2 levels, decreased p-MAPK and p-p70S6K levels, and slightly decreased p-GSK3 levels but had no significant effect on p-mTOR levels."
20643779
MAX affects TSC2
1 |
MAX decreases the amount of TSC2. 1 / 1
1 |
biopax:pid
No evidence text available
18056446
KISS1 affects TSC2
| 1
Modified KISS1 decreases the amount of TSC2. 1 / 1
| 1
reach
"Overexpression of KISS1 could significantly increase the mRNA expression of PIK3CG, PIK3C1, and PDK1, and significantly decreased the mRNA levels of FOXO3, TSC2, and BAD of PI3K signaling pathway."
30759773
JNK1-Bcl-2 affects TSC2
| 1
JNK1-Bcl-2 decreases the amount of TSC2. 1 / 1
| 1
reach
"However, DETA NONOate could further reduce EGFP-LC3 vesicles in AAA Myc-Bcl-2 expressing Tsc2 +/+ MEFs, but not in Tsc2 -/- MEFs, suggesting that the autophagy inhibition caused by NO was mediated predominantly (or maybe entirely) by the JNK1-Bcl-2 and mTORC1 pathways (XREF_FIG E)."
21726807
HTRA1 affects TSC2
| 1
HTRA1 decreases the amount of TSC2. 1 / 1
| 1
trips
"Our data suggest that, under particular physiologic or pathologic conditions, HtrA1 degrades TSC2 and activates the downstream targets."
20671064
HDAC_I affects TSC2
| 1
HDAC_I decreases the amount of TSC2. 1 / 1
| 1
reach
"Recent data demonstrate that inhibition of class I HDACs with apicidin induces the expression of tuberous sclerosis complex 2 (TSC2), an mTOR inhibitor, which inhibits mTOR mediated cardiac hypertrophy [XREF_BIBR]."
30825484
Glycosuria affects TSC2
| 1
Glycosuria decreases the amount of TSC2. 1 / 1
| 1
reach
"41, 42 In TB-DM patients, the effect of glycosuria on the urinary TB LAM test has not been evaluated yet.However, reports suggest that the MTB cell wall polysaccharide composition may change in TB-DM patients, which could alter the test sensitivity, due to the lower levels of urinary LAM concentration caused by glycosuria."
35646347
GSK3 affects TSC2
| 1
GSK3 decreases the amount of TSC2. 1 / 1
| 1
reach
"Chronic inhibition of GSK-3 enhanced glucose uptake and glucose transporter 1 (GLUT1) expression in TSC2 expressing (tuberous sclerosis complex 2) cells but not in cells lacking functional TSC2 [XREF_BIBR]."
26605788
GSK-3beta RNA interference affects TSC2
| 1
GSK-3beta RNA interference decreases the amount of TSC2. 1 / 1
| 1
reach
"The mRNA expression of TSC2 was also significantly inhibited by GSK-3beta RNA interference."
29291576
GHRL affects TSC2
| 1
GHRL decreases the amount of TSC2. 1 / 1
| 1
reach
"Furthermore, it demonstrates that ghrelin treatment reduces p-Tuberin expression induced by ingested sulfite."
29082888
FTO affects TSC2
| 1
FTO decreases the amount of TSC2. 1 / 1
| 1
reach
"The western blots showed that the total level and phosphorylated level of TSC1 but not TSC2 was up-regulated by Fto knockdown whereas FTO overexpression led to oppose results."
29501742
Etv proteins affects TSC2
| 1
Etv proteins decreases the amount of TSC2. 1 / 1
| 1
reach
"We also showed that Etv proteins suppresses mTOR activity by promoting Tsc2 expression, which is necessary for the nuclei clearance in mature lens."
32043969
EZH2 affects TSC2
| 1
EZH2 decreases the amount of TSC2. 1 / 1
| 1
reach
"Data revealed that EZH2 knockdown significantly increased protein levels of TSC2 and decreased protein levels of H3K27me3."
31783925
ERK inhibitor affects TSC2
| 1
ERK inhibitor decreases the amount of TSC2. 1 / 1
| 1
reach
"Moreover, ERK inhibitor increased TSC2 protein levels and attenuated mTOR activity in ANXA6 knockdown cells (Figure 6G)."
33135350
ELK1 affects TSC2
1 |
ELK1 decreases the amount of TSC2. 1 / 1
1 |
biopax:msigdb
No evidence text available
EGR3 affects TSC2
1 |
EGR3 decreases the amount of TSC2. 1 / 1
1 |
biopax:msigdb
No evidence text available
EGR2 affects TSC2
1 |
EGR2 decreases the amount of TSC2. 1 / 1
1 |
biopax:msigdb
No evidence text available
EGR1 affects TSC2
1 |
EGR1 decreases the amount of TSC2. 1 / 1
1 |
biopax:msigdb
No evidence text available
E6 affects TSC2
| 1
E6 decreases the amount of TSC2. 1 / 1
| 1
trips
"Over-expression of E6AP enhanced the degradation of TSC2 by HPV16 E6, while expression of a dominant negative E6AP (C833A) inhibited the E6-induced degradation."
18298802
Cyclin affects TSC2
| 1
Cyclin decreases the amount of TSC2. 1 / 1
| 1
reach
"Furthermore, shRNA mediated CUL4B knockdown caused an upregulation of TSC2 or cyclin E. XLID mutant (R388X), (R572C) or (V745A) CUL4B did not downregulate protein expression of TSC2 or cyclin E in neocortical neurons."
23348097
Circ-8073 affects TSC2
| 1
Circ-8073 decreases the amount of TSC2. 1 / 1
| 1
reach
"Meanwhile, knockdown Circ-8073 also decreased the protein levels of P110ALPHA PI3K, p-AKT / AKT and p-mTOR / mTOR (p < 0.01), and increased the protein level of TSC2, whereas the expression of P110ALP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29800603
Chd8 siRNA affects TSC2
| 1
Chd8 siRNA decreases the amount of TSC2. 1 / 1
| 1
reach
"Chd8 siRNA and Tsc2 siRNA effectively down-regulated Chd8 and Tsc2 expression in primary microglia, respectively (Fig. 1c,d)."
34497307
CX614 affects TSC2
| 1
CX614 decreases the amount of TSC2. 1 / 1
| 1
reach
"Although total levels of tuberin were reduced by BDNF and CX614 treatment, we found a slight increase in tuberin phosphorylation in BDNF- and CX614 stimulated hippocampal slices."
23467348
CCN4 affects TSC2
| 1
CCN4 decreases the amount of TSC2. 1 / 1
| 1
reach
"WISP1 (10 ng/ml) application decreased the expression of p-AMPK and the expression of p-TSC2 (Ser 1387), a downstream target of AMPK."
23244622
ATP13A2 affects TSC2
| 1
ATP13A2 decreases the amount of TSC2. 1 / 1
| 1
reach
"Accordingly, we found for the first time that ATP13A2 downregulation decreases TSC2 levels, by a mechanism dependent on MYCBP2 induced ubiquitination, which in turn activates mTORC1, inhibits TFEB translocation to the nucleus and compromises TFEB mediated transcription of SYT11."
27278822
AR affects TSC2
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AR decreases the amount of TSC2. 1 / 1
1 |
trrust
No evidence text available
21036700
APOE affects TSC2
| 1
APOE decreases the amount of TSC2. 1 / 1
| 1
reach
"These investigations suggest that reduced expression of KLF4 triggered by a high-fat diet in our mouse model (IR +/- IRS1 +/- ApoE -/-) may mediate down-regulation of IRS2 and TSC2 expression thereby impairing insulin signaling in adipocytes and promoting insulin resistance."
30240435
ANXA6 affects TSC2
| 1
ANXA6 decreases the amount of TSC2. 1 / 1
| 1
reach
"As shown in Figure 6G, ANXA6 knockdown increased the phosphorylation levels of ERK and decreased TSC2 protein levels."
33135350
AMPKα2 affects TSC2
| 1
AMPKα2 decreases the amount of TSC2. 1 / 1
| 1
reach
"In addition, SCs transfected with the miR-1764 agomir led to an improvement of proliferation capacity through down-regulating AMPKα2 level, which further decreased TSC2 expression and induced mTOR activation."
34481229
ACSL4 affects TSC2
| 1
Modified ACSL4 decreases the amount of TSC2. 1 / 1
| 1
reach
"ACSL4 expression reduces the phosphorylation levels of TSC2 on Thr172, decreasing its activity and inactivating the TCS1/2 complex."
26536660
6-formylindolo(3,2-b)carbazole decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
31676321
4-hydroxynon-2-enal decreases the amount of TSC2. 1 / 1
1 |
ctd
No evidence text available
12419474