IndraLab

Statements

USP49 affects Histone_H2B
| 6
USP49 deubiquitinates Histone_H2B. 6 / 6
| 6
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"It has been reported that USP49 deubiquitinates histone H2B and regulates co-transcriptional pre-mRNA splicing; interestingly, p53 is also mainly localized to the nucleus."
29748582
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"Silencing Usp49 induces relatively small changes in gene expression, however alterations in H2B ubiquitination levels caused by Usp49 regulate U1A and U2B association with chromatin and binding to nascent pre-mRNA."
25962961
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"Usp49 in complex with RVB1 and SUG1 yeast homologues deubiquitinates H2B, this modification is required for efficient co-transcriptional splicing of a large set of exons."
25962961
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"Here we report the purification of ubiquitin specific peptidase 49 (USP49) as a histone H2B specific deubiquitinase and demonstrate that H2B deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons."
23824326
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"USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."
23824326
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"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."
23824326
USP49 affects TP53
| 3
USP49 leads to the deubiquitination of TP53. 3 / 3
| 3
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"Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination."
29748582
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"USP49 suppresses p53 ubiquitination."
29748582
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"To assess this, we co-transfected HA-p53, Myc-ubiquitin, and Flag-USP49 into 293T cells, and found that USP49 suppressed ubiquitination of HA-p53."
29748582
USP49 affects STING1
1 | 2
USP49 deubiquitinates STING1. 3 / 3
1 | 2
ubibrowser
"Mechanistically, USP49 removes K63-linked ubiquitin chains from MITA after HSV-1 infection which inhibits the aggregation of MITA and the subsequent recruitment of TBK1 to the signaling complex."
30943264
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"USP49, a ubiquitin-specific protease, interacts with and deubiquitinates STING after HSV-1 infection."
35033428
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"Here, we report that USP49 interacts with and deubiquitinates MITA after HSV-1 infection, thereby turning down cellular antiviral responses."
30943264
USP49 affects FKBP4
1 | 2
USP49 deubiquitinates FKBP4. 3 / 3
1 | 2
ubibrowser
"Here we report that a deubiquitinase, USP49, is a new regulator of the AKT pathway.| Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."
28363942
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"Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP 's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."
28363942
reach
"Recent studies show that DUBs play essential roles in proliferation, motility, and chemoresistance of malignant cells through stabilizing critical proteins.5 For example, USP49 deubiquitinates FKBP51, which serves as a scaffold for dephosphorylating Ser473 residue at Akt, and further sensitizes pancreatic cancer cells to gemcitabine."
30296012
USP49 affects PAX9
| 2
USP49 deubiquitinates PAX9. 2 / 2
| 2
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"We identify and demonstrate that USP49 interacts with and deubiquitinates PAX9 and MSX1, thereby extending their protein half-lives."
35273362
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"In sum, our results suggest that deubiquitination of PAX9 and MSX1 by USP49 stabilizes their protein levels to facilitate successful odontogenesis."
35273362
USP49 affects H2BC21
2 |
USP49 deubiquitinates H2BC21. 2 / 2
2 |
ubibrowser
No evidence text available
ubibrowser
"USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."
23824326
USP49 affects gemcitabine
| 1
USP49 deubiquitinates gemcitabine. 1 / 1
| 1
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"Recent studies show that DUBs play essential roles in proliferation, motility, and chemoresistance of malignant cells through stabilizing critical proteins.5 For example, USP49 deubiquitinates FKBP51, which serves as a scaffold for dephosphorylating Ser473 residue at Akt, and further sensitizes pancreatic cancer cells to gemcitabine."
30296012
USP49 affects PTEN
| 1
USP49 deubiquitinates PTEN. 1 / 1
| 1
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"Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells."
31001918
USP49 affects MSX1
| 1
USP49 deubiquitinates MSX1. 1 / 1
| 1
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"In sum, our results suggest that deubiquitination of PAX9 and MSX1 by USP49 stabilizes their protein levels to facilitate successful odontogenesis."
35273362
USP49 affects MDM2-p53 axis genes
| 1
USP49 leads to the deubiquitination of MDM2-p53 axis genes. 1 / 1
| 1
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"Therefore, our findings indicated that USP49-mediated H2B deubiquitination controls the transcription of MDM2-p53 axis genes in the process of HCT116 cell proliferation."
35072515
USP49 affects H2BC10
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USP49 deubiquitinates H2BC10. 1 / 1
1 |
ubibrowser
"USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing"
23824326
USP49 affects H2AX
| 1
USP49 leads to the deubiquitination of H2AX. 1 / 1
| 1
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"Over-expressed USP49 suppressed ubiquitylation of γH2AX in an enzymatic activity-dependent manner."
35598681
USP49 affects FKBP5
1 |
USP49 deubiquitinates FKBP5. 1 / 1
1 |
ubibrowser
"Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."
28363942
USP49 affects DUSP1
1 |
USP49 deubiquitinates DUSP1. 1 / 1
1 |
ubibrowser
"Moreover, USP49 positively regulated DUSP1 expression through deubiquitinating DUSP1."
30246457
USP49 affects BAG2
| 1
USP49 deubiquitinates BAG2. 1 / 1
| 1
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"Investigation of mechanisms unravels that USP49 deubiquitinates and stabilizes Bcl-2-Associated Athanogene 2 (BAG2), a well-known protein that antagonizes apoptosis and enables adaptive response of CRC cells."
35367823