IndraLab

Statements

USP48 affects TRAF2
2 | 1
USP48 deubiquitinates TRAF2. 3 / 3
2 | 1
ubibrowser
"Here we reveal USP48 as the first identified DUB to deubiquitinate and stabilize TRAF2 in epithelial cells."
28874458
ubibrowser
"The deubiquitinating enzyme USP48 stabilizes TRAF2 and reduces E-cadherin-mediated adherens junctions"
28874458
reach
"USP48 (also known as USP31) interacted with and deubiquitinated TRAF2 in beas2B cells [71]."
31208841
USP48 affects MDM2
| 1
USP48 leads to the deubiquitination of MDM2. 1 / 1
| 1
reach
"In contrast to other deubiquitinating enzymes (DUBs) that have been previously implicated in the regulation of Mdm2 protein stability, USP48 did not induce Mdm2 stabilization by significantly reducing Mdm2 ubiquitination levels."
28233861
USP48 affects H2AC8
1 |
USP48 deubiquitinates H2AC8. 1 / 1
1 |
ubibrowser
"USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A"
29335415
USP48 affects H2AC19
1 |
USP48 deubiquitinates H2AC19. 1 / 1
1 |
ubibrowser
"Here we identify ubiquitin specific protease-48 (USP48) as a H2A DUB, specific for the C-terminal BRCA1 ubiquitination site."
29335415
USP48 affects GLI1
1 |
USP48 deubiquitinates GLI1. 1 / 1
1 |
ubibrowser
"Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1"
28623188
USP48 affects FANCI
| 1
Modified USP48 leads to the deubiquitination of FANCI. 1 / 1
| 1
reach
"Our data demonstrate that loss of USP48 does not restore FANCI and FANCD2 monoubiquitylation or FANCD2 recruitment at ICLs, but if USP48 targets one or more sites on H2A that can be recognized by these nucleases, then loss of USP48 might bypass the requirement of the FA proteins and allow the recruitment of FAN1 or SLX4 and subsequent unhooking of the ICL in an FA deficient background."
29891926
USP48 affects FANCD2
| 1
Modified USP48 leads to the deubiquitination of FANCD2. 1 / 1
| 1
reach
"Our data demonstrate that loss of USP48 does not restore FANCI and FANCD2 monoubiquitylation or FANCD2 recruitment at ICLs, but if USP48 targets one or more sites on H2A that can be recognized by these nucleases, then loss of USP48 might bypass the requirement of the FA proteins and allow the recruitment of FAN1 or SLX4 and subsequent unhooking of the ICL in an FA deficient background."
29891926