IndraLab

Statements

USP44 affects CDC20
1 | 13
USP44 deubiquitinates CDC20. 10 / 14
1 | 13
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"Moreover, Usp44, a ubiquitin isopeptidase, has been proposed to prevent the autoubiquitination of Cdc20 and maintain the Mad2-Cdc20 interaction during checkpoint activation."
21439394
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"USP44 knockdown increased Cdc20 polyubiquitination and centrosomal Cdc20-APC activity in neurons, and correspondingly promoted the elaboration of dendrites."
20195072
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"Knockdown of USP44 in neurons dramatically increased the polyubiquitination of Cdc20 and centrosomal Cdc20-APC activity, confirming that endogenous USP44 deubiquitinates Cdc20 in neurons (XREF_FIG)."
19167333
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"We have previously shown that USP44 deubiquitinates CDC20 to negatively regulate the anaphase promoting complex during the spindle checkpoint."
19615732
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"USP44 deubiquitinates the APC coactivator Cdc20 both in vitro and in vivo, and thereby directly counteracts the APC driven disassembly of Mad2-Cdc20 complexes (discussed in an accompanying paper)."
17443180
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"Conversely, the deubiquitinating enzyme USP44 deubiquitinates Cdc20 and drives the assembly of the inhibitory SAC complexes."
18645024
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"USP44 deubiquitinates Cdc20 and enables the stabilization of the inactive complex MAD2, CDC20, and APC/C [XREF_BIBR]."
23246971
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"Knocking down USP14 arrests cell cycle at the G2/M phase and inhibits the proliferation and migration of breast cancer cells, USP44 deubiquitinates the APC-inhibitory Mad2 and Cdc20 complex, thereby preventing anaphase onset."
33643919
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"This study indicates that USP44 reduces Cdc20 autoubiquitination and protects the Mad2-Cdc20-containing checkpoint complexes from disassembly, although it remains to be determined whether USP44 also directly deubiquitinates mitotic APC/C substrates and prevents their degradation."
17650307
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"For example, USP44 directly deubiquitinates CDC20 and counteracts the APC driven disassembly of the Mad2 and CDC20 complex, which regulates the proper mitotic timing and the spindle checkpoint function 3."
29449677
USP44 affects Histone_H2B
| 8
USP44 deubiquitinates Histone_H2B. 8 / 8
| 8
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"Our results indicate that both the deubiquitination of histone H2B by USP44 and deacetylation of histone H3 by HDAC3 contribute to N-CoR mediated transcriptional repression (XREF_FIG)."
27880911
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"29 , 30 Of note, USP44 deubiquitinates histone H2B both in vivo and in vitro, which contributes to N‐CoR (USP44 is a part of the N‐CoR complex)‐mediated repression of target genes."
32394588
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"However, whether USP44 directly deubiquitinates histone H2B or how its activity is targeted to chromatin is not known."
27880911
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"As part of N-CoR, USP44 deubiquitinates H2B both in vivo and in vitro, and it contributes to N-CoR-mediated repression of target genes, including a genome integrated luciferase reporter (Vaquero et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
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"USP44 within N-CoR deubiquitinates H2B in vitro and in vivo, and ablation of USP44 impairs the repressive activity of the N and CoR complex."
27880911
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"However, whether USP44 directly deubiquitinates histone H2B or how its activity is targeted to chromatin are not known."
27880911
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"USP44 negatively regulates H2B ubiquitination during embryonic stem cell development [XREF_BIBR]."
23845989
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"Our results indicate that both the deubiquitination of histone H2B by USP44 and deacetylation of histone H3 by HDAC3 contribute to N-CoR-mediated transcriptional repression."
27880911
USP44 affects FOXP3
| 6
USP44 deubiquitinates FOXP3. 4 / 4
| 4
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"USP44 co-operates with USP7 to deubiquitinate FOXP3 and stabilize expression."
32644293
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"Interestingly, USP44 co-operated with USP7 to deubiquitinate and stabilize FOXP3."
32644293
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"To this end, we characterized the deubiquitination of FOXP3 by USP44 invitro in the presence of wild-type ubiquitin molecules and mutants lacking all but specific lysine residues."
32644293
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"We therefore investigated whether or not USP44 co-operates with USP7 to deubiquitinate and preserve FOXP3."
32644293
Modified USP44 leads to the deubiquitination of FOXP3. 2 / 2
| 2
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"As expected, USP44 or USP7 expression alone reduced ubiquitination of FOXP3, while co-over-expression of both USP44 and USP7 almost completely eliminated FOXP3 polyubiquitination, suggesting a synergistic role of these two DUBs (Fig XREF_FIG C)."
32644293
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"In these experiments, ubiquitination of FOXP3 was decreased by the co-expression of USP44 in the presence of wild-type ubiquitin."
32644293
USP44 affects DDB2
| 6
USP44 deubiquitinates DDB2. 6 / 6
| 6
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"Ubiquitination of DDB2 was reversed by the inclusion of wild-type USP44 but not the catalytically inactive USP44C281A."
33937266
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"USP44 Deubiquitinates and Prevents the Premature Degradation of DDB2."
33937266
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"Here we show that the tumor suppressor USP44 directly deubiquitinates DDB2 to prevent its premature degradation and is selectively required for CPD repair."
33937266
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"One possibility is that USP44 de-ubiquitinates DDB2 once it has been released, allowing it to be recycled back onto persisting CPDs."
33937266
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"Consistent with the selective CPD repair defect in Usp44 null cells, we find that USP44 deubiquitinates the recognition protein DDB2 to facilitate its accumulation on DNA lesions and facilitate the subsequent recruitment of XPC."
33937266
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"These data lead us to conclude that USP44 deubiquitinates DDB2 following UV exposure and prevents its premature degradation."
33937266
USP44 affects H2Bub1
| 3
USP44 deubiquitinates H2Bub1. 3 / 3
| 3
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"USP44 deubiquitinates H2Bub1 as part of N-CoR."
27880911
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"To further define USP44 functions, we tested the ability of recombinant USP44 to deubiquitinate H2Bub1 in vitro (XREF_SUPPLEMENTARY, compare lane 1 to lane 2 and 3)."
27880911
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"USP44 promotes H2Bub1 deubiquitylation."
22681888
USP44 affects MAD2L1
1 | 1
USP44 deubiquitinates MAD2L1. 2 / 2
1 | 1
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"Knocking down USP14 arrests cell cycle at the G2/M phase and inhibits the proliferation and migration of breast cancer cells, USP44 deubiquitinates the APC-inhibitory Mad2 and Cdc20 complex, thereby preventing anaphase onset."
33643919
ubibrowser
"USP39 deubiquitinates aurora B kinase maintaining spindle assembly checkpoint integrity [103] while USP44 stabilizes Mad2/Cdc20 complex inhibiting premature activation of the APC/CCdh1?complex"
25121098
USP44 affects Histone_H3
| 2
USP44 deubiquitinates Histone_H3. 2 / 2
| 2
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"Our results indicate that both the deubiquitination of histone H2B by USP44 and deacetylation of histone H3 by HDAC3 contribute to N-CoR-mediated transcriptional repression."
27880911
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"Our results indicate that both the deubiquitination of histone H2B by USP44 and deacetylation of histone H3 by HDAC3 contribute to N-CoR mediated transcriptional repression (XREF_FIG)."
27880911
USP44 affects luciferase reporter
| 1
USP44 deubiquitinates luciferase reporter. 1 / 1
| 1
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"As part of N-CoR, USP44 deubiquitinates H2B both in vivo and in vitro, and it contributes to N-CoR-mediated repression of target genes, including a genome integrated luciferase reporter (Vaquero et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
USP44 affects RNF8
| 1
USP44 deubiquitinates RNF8. 1 / 1
| 1
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"Recruitment of USP44 to DNA damage sites was shown to be dependent on RNF168 and it was suggested that USP44 binds to and deubiquitinates RNF8 and RNF168 dependent ubiquitination at DSB, though it is [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28624371
USP44 affects RNF168
| 1
USP44 deubiquitinates RNF168. 1 / 1
| 1
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"Recruitment of USP44 to DNA damage sites was shown to be dependent on RNF168 and it was suggested that USP44 binds to and deubiquitinates RNF8 and RNF168 dependent ubiquitination at DSB, though it is [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28624371
USP44 affects POU5F1
1 |
USP44 deubiquitinates POU5F1. 1 / 1
1 |
USP44 affects PCNA
| 1
USP44 leads to the deubiquitination of PCNA. 1 / 1
| 1
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"In undamaged cells, the deubiquitinating enzyme USP44 prevents PCNA ubiquitination and recruitment of error-prone DNA polymerases, and is proposed as a safeguard mechanism against the mutagenic effects of these polymerases."
20458729
USP44 affects Histone
| 1
USP44 leads to the deubiquitination of Histone-H2A. 1 / 1
| 1
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"USP44 promoted deubiquitination of histones H2A and H2B in vitro, localized to DNA damage foci, and inhibited the local formation of polyubiquitin chains at the sites of DNA damage."
24647359
USP44 affects H2BK120ub1
| 1
USP44 deubiquitinates H2BK120ub1. 1 / 1
| 1
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"As a central component of the nuclear receptor corepressor (NCoR) complex, USP44 has been shown to coordinate deubiquitination of H2BK120ub1 and transcriptional repression [157]."
32708614
USP44 affects H2BK120ub
| 1
USP44 deubiquitinates H2BK120ub. 1 / 1
| 1
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"Other major DUBs with specificity for histone H2AK119ub over H2BK120ub are BAP1 and USP16, while USP3, USP12, USP22, and USP44 deubiquitinate both H2AK119ub and H2BK120ub, as well as different non histone substrates [XREF_BIBR]."
32344625
USP44 affects H2BC21
1 |
USP44 deubiquitinates H2BC21. 1 / 1
1 |
ubibrowser
No evidence text available
USP44 affects H2AK119ub
| 1
USP44 deubiquitinates H2AK119ub. 1 / 1
| 1
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"Other major DUBs with specificity for histone H2AK119ub over H2BK120ub are BAP1 and USP16, while USP3, USP12, USP22, and USP44 deubiquitinate both H2AK119ub and H2BK120ub, as well as different non histone substrates [XREF_BIBR]."
32344625
USP44 affects H2AC20
1 |
USP44 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"Both USP44 and USP29 promoted efficient deubiquitylation of histone H2A"
23615962
USP44 affects H2AC17
1 |
USP44 deubiquitinates H2AC17. 1 / 1
1 |
USP44 affects FBP1
| 1
USP44 leads to the deubiquitination of FBP1. 1 / 1
| 1
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"Importantly, we revealed USP44 promoted FBP1 deubiquitination to increase FBP1 protein expression in pancreatic cancer, which might be one of the underlying mechanisms of USP44 impeding the progression of pancreatic cancer."
31497353
USP44 affects EZH2
| 1
USP44 deubiquitinates EZH2. 1 / 1
| 1
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"Another recent study found that USP44 deubiquitinates and stabilizes the expression an activity of the histone methyltransferase EZH2 in prostate tumor cells as well as oncogenic mutants of this epigenetic factor with pro tumor results."
32644293
USP44 affects Cdc20-APC
| 1
USP44 leads to the deubiquitination of Cdc20-APC. 1 / 1
| 1
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"USP44 knockdown increased Cdc20 polyubiquitination and centrosomal Cdc20-APC activity in neurons, and correspondingly promoted the elaboration of dendrites."
20195072
USP44 affects Cdc20 MCC
| 1
USP44 leads to the deubiquitination of Cdc20 MCC. 1 / 1
| 1
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"Furthermore, USP44 catalyses Cdc20 MCC deubiquitination, thereby antagonizing Cdc20 MCC ubiquitination to stabilize the APC/C MCC, thus sustaining the SAC [XREF_BIBR]."
29167309
USP44 affects AXIN1
| 1
USP44 deubiquitinates AXIN1. 1 / 1
| 1
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"This indicates that USP44 deubiquitination of Axin1 increases beta-catenin degradation, inhibits Wnt and beta-catenin signaling, and affects CRC [XREF_BIBR]."
32486158
USP44 affects APC
| 1
USP44 deubiquitinates APC. 1 / 1
| 1
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"USP44 deubiquitinates the APC coactivator Cdc20 both in vitro and in vivo, and thereby directly counteracts the APC driven disassembly of Mad2-Cdc20 complexes (discussed in an accompanying paper)."
17443180
USP44 affects ANGPTL4
| 1
USP44 deubiquitinates ANGPTL4. 1 / 1
| 1
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"As part of N-CoR, USP44 deubiquitinates H2B both in vivo and in vitro, and it contributes to N-CoR-mediated repression of target genes, including a genome integrated luciferase reporter (Vaquero et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911