IndraLab

Statements


USP40 affects HINT1
| 3
USP40 deubiquitinates HINT1. 2 / 2
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"In conclusion, USP40 bound to Nestin deubiquitinates HINT1, and in consequence upregulates p53."

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"USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage."
USP40 deubiquitinates HINT1 on histidine. 1 / 1
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"We also found that USP40 deubiquitinated histidine triad nucleotide-binding protein 1 (HINT1), an inducer of p53."
USP40 affects CFLAR
| 2
USP40-C62A deubiquitinates CFLAR. 1 / 1
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"GST pull-down assay results show mutant USP40 (C62A) did not de-ubiquitinate CFLAR (Additional file 1: Figure S4D)."
USP40 leads to the deubiquitination of CFLAR. 1 / 1
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"Results show that overexpression of USP40 decreased the ubiquitination of CFLAR (Fig. 4d), and knockdown USP40 increased the ubiquitination of CFLAR (Fig. 4e)."
USP40 affects TP53
| 1
USP40 deubiquitinates TP53 on histidine. 1 / 1
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"We also found that USP40 deubiquitinated histidine triad nucleotide-binding protein 1 (HINT1), an inducer of p53."