IndraLab

Statements

USP32 affects RAB7A
| 4
USP32 deubiquitinates RAB7A. 3 / 3
| 3
reach
"This suggested that deubiquitylation of Rab7 by USP32 promotes release of Rab7 from the membrane to the cytosol, where a new functional cycle of this Rab can commence (Fig. 5i)."
30926795
reach
"Taken together with the observations on endosomal transport (Fig. 6), these findings support a model wherein deubiquitylation of Rab7 by USP32 exerts multifaceted control over membrane dynamics at the LE/MVB by promoting their intracellular motility as well as enabling efficient recycling from these organelles (Fig. 9)."
30926795
reach
"Having established that USP32 can deubiquitylate Rab7 in vitro and in situ, we sought to understand the interplay between USP32 and Rab7 in endosome biology."
30926795
USP32 deubiquitinates RAB7A on K191. 1 / 1
| 1
reach
"Cellular ubiquitome profiling revealed deubiquitylation of Rab7 by USP32 on K191, located in the solvent-exposed flexible C-terminal region of the molecule."
30926795
USP32 affects RAB5A
| 1
USP32 deubiquitinates RAB5A. 1 / 1
| 1
reach
"In contrast to Rab7 (and in agreement with the proteomic analysis above), no deubiquitylation of GFP-Rab5 by USP32 was observed under the same reaction conditions (Fig. 4d; Supplementary Fig. 5e)."
30926795
USP32 affects RAB35
| 1
USP32 deubiquitinates RAB35. 1 / 1
| 1
reach
"Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours."
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