IndraLab

Statements

USP21 affects RIPK1
1 1 |
USP21 deubiquitinates RIPK1. 1 / 1
1 |
ubibrowser
"The contrast in the phenotype of the Usp21-knockout line with the previously characterized GATA3 and RIPK1 knockout mice strongly indicates that USP21 is redundant for the regulation of GATA3 and RIPK1 activity during mouse development, in hematopoietic stem cells, and in lymphocyte differentiation."
25680095
USP21 deubiquitinates RIPK1 on K377. 1 / 1
1 |
biopax:reactome
No evidence text available
USP21 affects NANOG
1 | 1
USP21 deubiquitinates NANOG. 2 / 2
1 | 1
reach
"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."
30891497
ubibrowser
"Review"
28279784
USP21 affects FOXM1
1 | 1
USP21 deubiquitinates FOXM1. 2 / 2
1 | 1
reach
"HDACi treatment increased the ubiquitination level of FOXM1 by suppressing ubiquitin-specific peptidase 21 (USP21), which deubiquitinates FOXM1."
34335925
ubibrowser
"We identified USP21 in an RNAi-based screen for deubiquitinases that control FOXM1 abundance."
30865895
USP21 affects BAZ2A
2 |
USP21 deubiquitinates BAZ2A. 2 / 2
2 |
ubibrowser
"Deubiquitinates BAZ2A/TIP5 leading to its stabilization"
26100909
ubibrowser
No evidence text available
USP21 affects STING1
1 |
USP21 deubiquitinates STING1. 1 / 1
1 |
ubibrowser
"In this study, we found that USP21 is an important deubiquitinating enzyme for STING and that it negatively regulates the DNA virus-induced production of type I interferons by hydrolyzing K27/63-linked polyubiquitin chain on STING."
28254948
USP21 affects SLCO6A1
| 1
USP21 deubiquitinates SLCO6A1. 1 / 1
| 1
reach
"Ub-GST was also efficiently deubiquitinated by USP2-3 incrementSRM."
26484888
USP21 affects PRC1
| 1
USP21 deubiquitinates PRC1. 1 / 1
| 1
reach
"When combined with the protein regulator of cytokinesis 1, USP16 can deubiquitinate histone H2A and control gene expression (PRC1)."
35406655
USP21 affects MAP2K2
1 |
USP21 deubiquitinates MAP2K2. 1 / 1
1 |
ubibrowser
"The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth"
29706623
USP21 affects IL33
1 |
USP21 deubiquitinates IL33. 1 / 1
1 |
ubibrowser
"Furthermore, depletion of USP21 reduces IL-33 protein levels and IL-33-mediated NF-kappaB p65 promoter activity."
25197364
USP21 affects H2AX
| 1
USP21 deubiquitinates H2AX. 1 / 1
| 1
reach
"USP3, USP51 and USP16 de-ubiquitinate H2A/H2AX with varying degrees of specificity [47–49]."
31769469
USP21 affects H2AW
1 |
USP21 deubiquitinates H2AW on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP21 affects H2AC20
1 |
USP21 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator."
21179169
USP21 affects H2AC17
1 |
USP21 deubiquitinates H2AC17. 1 / 1
1 |
ubibrowser
"In this study, we report that H2Aub markedly decreases in hepatocellular carcinoma. Usp21, a H2A deubiquitinase, is probably responsible for decrease in H2Aub."
27190257
USP21 affects GATA3
1 |
USP21 deubiquitinates GATA3. 1 / 1
1 |
USP21 affects FOXP3
1 |
USP21 deubiquitinates FOXP3. 1 / 1
1 |
ubibrowser
"USP21 stabilizes FOXP3 protein by mediating its deubiquitination and maintains the expression of Treg signature genes."
27857073
USP21 affects DDX58
1 |
USP21 deubiquitinates DDX58. 1 / 1
1 |
ubibrowser
"Another study demonstrated that USP21 deubiquitinates RIG‐1, an essential protein in antiviral immune defense."
27341175
USP21 affects BRCA2
1 |
USP21 deubiquitinates BRCA2. 1 / 1
1 |
ubibrowser
"Together, our findings identify deubiquitination as a means to regulate BRCA2 function and point to USP21 as a potential therapeutic target in BRCA2-proficient tumors."
28743957