IndraLab

Statements

USP16 affects PLK1
1 | 7
USP16 deubiquitinates PLK1. 8 / 8
1 | 7
ubibrowser
"ubiquitinspecific peptidase 16 (Usp16) was identified as a PLK1 interacting protein in a co-immunoprecipitation (co-IP) assay in a PBD-dependent manner"
28188342
reach
"In this study, we show that ubiquitin specific peptidase 16 (Usp16) is a novel substrate for Plk1, and sequential phosphorylation by CDK1 and Plk1 activates Usp16, which, in turn, deubiquitinates Plk1 and promotes the recruitment of Plk1 to, and its retention on, the kinetochores for proper chromosome alignment."
26323689
reach
"Collectively, these results suggest that Plk1 is ubiquitinated by CUL3 based ubiquitin ligase in vivo, and the ubiquitination of Plk1 could be reversed by Usp16, which interacts with Plk1 in a PBD dependent manner in early mitosis."
26323689
reach
"Usp16 interacts with and deubiquitinates Plk1."
26323689
reach
"Because Usp16 deubiquitinates Plk1, we wondered whether Plk1 mediated Usp16 activation would also enhance the deubiquitination of Plk1 itself."
26323689
reach
"When Usp16 was knocked down by siRNA, we found that the ladder pattern bands above the main Plk1 band were enhanced, confirming our previous speculation that Usp16 might deubiquitinate Plk1 (XREF_FIG)."
26323689
reach
"CDK1 and Plk1 sequentially phosphorylate and activate Usp16, which in turn deubiquitinates Plk1 to maintain the kinase 's kinetochore localization and promote proper chromosome alignment in mitosis."
26323689
reach
"Usp16 deubiquitinates Plk1, resulting in an enhanced interaction with kinetochore localized proteins such as BubR1, and thereby retains Plk1 on the kinetochores to promote proper chromosome alignment in early mitosis."
26323689
USP16 affects MYC
| 2
USP16 deubiquitinates MYC. 2 / 2
| 2
reach
"USP16 deubiquitinates c-Myc."
33546726
reach
"Besides, the knockdown of USP16 significantly enhanced the polyubiquitination of c-Myc."
33546726
USP16 affects NANOG
1 |
USP16 deubiquitinates NANOG. 1 / 1
1 |
USP16 affects Histone_H2B
| 1
USP16 deubiquitinates Histone_H2B on lysine. 1 / 1
| 1
reach
"USP16 specifically deubiquitinates histone H2A on lysine (K) 119 and K15 but not H2B in vivo, which leads to subsequent phosphorylation of H3 and chromosome segregation."
| PMC
USP16 affects H2Aub1
| 1
USP16 deubiquitinates H2Aub1. 1 / 1
| 1
reach
"This kinase phosphorylates and activates the Usp16 deubiquitinase, which then deubiquitinates H2Aub1 (XREF_FIG)."
26665172
USP16 affects H2AW
1 |
USP16 deubiquitinates H2AW on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects H2AC20
1 |
USP16 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
No evidence text available
USP16 affects H2AC17
1 |
USP16 deubiquitinates H2AC17. 1 / 1
1 |
ubibrowser
"USP3 and USP16 function to remove ubiquitin from histone H2A during the DDR"
28778421