IndraLab

Statements

USP10 affects TP53
1 | 61
USP10 deubiquitinates TP53. 10 / 58
1 | 57
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"Because USP10 is a p53 deubiquitinating enzyme, p53 ubiquitination was decreased by transfection of USP10 (compare lanes 3 and 4), whereas deubiquitination of p53 by USP10 was inhibited by co-transfection of USP10 and G3BP1 (compare lanes 4 and 5)."
24998844
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"Under stress condition, ATM phosphorylates USP10, which then deubiquitinates and targets cytoplasmic p53 back to the nucleus."
29479529
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"These results demonstrate that USP10 deubiquitinates p53 both in vitro and in vivo."
20096447
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"USP10 deubiquitinates both wild-type p53 and mutp53."
32722796
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"Moreover, they also found that p53, which can be deubiquitinated by USP10, negatively regulates the expression of miR-138 through binding to the miRNA’s promoter region [31]."
35627217
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"USP10 deubiquitinates p53 and reverses MDM2 mediated nuclear transport and degradation of p53."
25606592
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"Here we report that USP10, a cytoplasmic ubiquitin specific protease, deubiquitinates p53, reversing Mdm2 induced p53 nuclear export and degradation."
20096447
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"Resveratrol (RSVL) directly binds to G3BP1 and prevents the interaction of G3BP1/USP10, which enhances the USP10-mediated de-ubiquitination of p53, thereby increasing p53 expression (135)."
34526993
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"G3BP1 also inhibited USP10 mediated deubiquitination of endogenous p53 in HCT116 cells (XREF_FIG)."
24998844
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"Once in the cytoplasm, p53 can be deubiquitinated by the deubiquitinase USP10, resulting in its translocation back to the nucleus (Yuan et al., 2010) [pathway (3) in Figure 2]."
22188262
USP10 leads to the deubiquitination of mutated TP53. 2 / 2
| 2
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"However, it is unclear whether USP10 antagonizes ubiquitination of mutp53 by other ubiquitin ligases, USP10 alters subcellular localization of mutp53, and USP10 plays a role in deubiquitination of different TP53 mutants."
30577483
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"USP10 deubiquitinates and stabilizes both wt and mutant p53."
26734569
USP10-C424A deubiquitinates TP53. 1 / 1
| 1
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"We confirmed that wild-type USP10 but not USP10 C424A deubiquitinates the p53 protein (XREF_SUPPLEMENTARY C)."
30469013
Modified USP10 leads to the deubiquitination of mutated TP53. 1 / 1
| 1
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"Coexpression of USP10 together with Mdm2 decreased mutant p53 ubiquitination (XREF_SUPPLEMENTARY), while downregulation of USP10 increased mutant p53 ubiquitination (XREF_SUPPLEMENTARY), suggesting that USP10 also regulates mutant p53 ubiquitination."
20096447
USP10 affects BECN1
1 | 12
USP10 deubiquitinates BECN1. 10 / 12
1 | 11
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"It promotes the degradation of Vps34 complexes by inhibiting USP10 and USP13, two ubiquitin specific peptidases that target the deubiquitination of Beclin-1."
26530936
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"Since USP10 mediates the deubiquitination of Beclin1 and reduced levels of USP10 leads to increased ubiquitination and degradation of Vps34 complexes, reduced levels of Vps34 complexes as a result of USP10 reduction may in turn lead to destabilization of USP13."
21962518
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"On the other hand, autophagy can be also inhibited blocking PI3KC3 complex formation; Spautin-1 indirectly inhibits the activity of VPS34 by proteosomal degradation of proteins that form VPS34 complexes through reduction of Beclin-1 deubiquitination mediated by USP10 and USP13 [120]."
31635099
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"USP10 has also been shown to enhance autophagy by deubiquitinating beclin-1, a component of class-III PI3K complexes that catalyze the formation of phosphatidylinositol 3-phosphate at both autophagy initiation and autophagosome maturation steps."
33577797
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"Inhibition of the Deubiquitinating Enzymes USP10 and USP13 Causes Ubiquitination of Beclin 1."
25545884
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"Conversely, it was show that Beclin 1 is deubiquitinated by USP10 and USP13 and adding complexity, Beclin 1 itself controlled the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities, in turn regulating the levels of tumor suppressor p53 [XREF_BIBR]."
24729948
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"Furthermore, the presence of spautin-1 inhibited the deubiquitination of Beclin1 mediated by USP10 and USP13."
21962518
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"Specific and potent autophagy inhibitor-1 (Spautin-1) was identified to inhibit USP10 and USP13, which deubiquitinate the Beclin 1 subunit of Vsp34 complex, and thus promoted the degradation of Vsp34 PI3 kinase complex."
23797609
ubibrowser
"While A20 inhibits PtdIns3P signaling by removing the TRAF6-dependent Lys63-linked chains from Beclin 1, the enzymes USP10 and USP13 prevent PI3K-III complex components from their degradation and, therefore, support autophagy. Interestingly enough, USP10 also stabilizes p53, which, in turn, triggers the degradation of Beclin 1 and VPS34 in order to prevent autophagy."
26445063
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"We demonstrate that USP10 and USP13 can both mediate the deubiquitination of Beclin1."
21962518
Mutated USP10 leads to the deubiquitination of BECN1. 1 / 1
| 1
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"As shown in XREF_FIG, the coincubation of ubiquitinated Beclin1 with USP10 or USP13 but not a catalytically inactive USP10 mutant reduced the levels of Beclin1 ubiquitination."
21962518
USP10 affects CFTR
1 | 11
USP10 deubiquitinates CFTR. 10 / 11
1 | 10
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"Inhibition of USP10 suppresses post-endocytic de-ubiquitination of CFTR, and the cell targets the ion channel to the lysosome rather than recycling it into the apical membrane."
28392259
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"USP10 decreases the ubiquitination of CFTR, whereas the knockdown of USP10 promotes the ubiquitination and reduction of CFTR at the cell surface [XREF_BIBR]."
| PMC
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"USP10 deubiquitinates CFTR in endosomes, thereby increasing the probability of endocytic recycling, which in turn helps to maintain the abundance of CFTR at the plasma membrane."
| DOI
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"Functionally, Cif stabilizes an intracellular complex of a DUB (USP10) and G3BP1, preventing deubiquitylation of CFTR, which is required for recycling the receptor to the plasma membrane XREF_BIBR."
22927812
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"We previously reported that the DUB USP10 deubiquitinates CFTR in early endosomes of human airway epithelial cells XREF_BIBR."
21455491
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"Cif stabilizes a G3BP1:USP10 complex in lung cells which renders USP10 inactive and thus unable to deubiquitinate CFTR (20, 36, 71) ."
| DOI
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"Although it has been shown that USP10 deubiquitinates and degrades CFTR [64], Pesce et al. found that spautin-1 could not affect the expression of CFTR, indicating that spautin-1 affected CF progression in a USP10-independent manner."
35627217
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"In a recent study, we demonstrated that USP10, a host cell DUB, deubiquitinates CFTR in endosomes, thereby reducing the lysosomal degradation of CFTR, and maintaining cell and plasma membrane CFTR XREF_BIBR."
21455491
ubibrowser
"Review"
27775833
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"The ability of USP10 to efficiently deubiquitinate CFTR in the early endosome allows for efficient endocytic recycling of CFTR and thus the long half-life of CFTR (approximately 8-24 h in polarized human airway cells) in the plasma membrane."
20215869
Unubiquitinated USP10 leads to the deubiquitination of CFTR. 1 / 1
| 1
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"In P. aeruginosa, the OMV associated toxin CFTR-inhibitory factor (Cif) controls the host deubiquitylating enzyme USP10 to cause increased ubiquitylation of cystic fibrosis transmembrane conductance regulator (CFTR), which is involved in mucus production."
26373371
USP10 affects AMPK_alpha
| 10
USP10 deubiquitinates AMPK_alpha. 9 / 9
| 9
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"Mechanistically, following the energy deprivation, USP10 largely deubiquitinates AMPKalpha so that its activating phosphorylation by LKB1 could be greatly enhanced."
27681874
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"As shown in XREF_FIG and XREF_SUPPLEMENTARY, knockdown of USP10 increased the ubiquitination of WT AMPKalpha; on the other hand, knockdown of USP10 did not affect ubiquitination levels of the AMPKalpha 4KR mutant (XREF_FIG and XREF_SUPPLEMENTARY)."
26876938
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"We further overexpressed WT USP10 or catalytic inactive mutant in USP10 deficient cells and found that WT USP10, but not the CA mutant decreased ubiquitination of AMPKalpha (XREF_FIG and XREF_SUPPLEMENTARY), suggesting that USP10 regulates AMPKalpha ubiquitination in cells."
26876938
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"In this study, we identified that USP10 can deubiquitinate PTEN and AMPKalpha and the stabilization of these two proteins will subsequently suppress the activation of AKT and mTOR in HCC cells."
30056112
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"As shown in Figures 3 E and S3 D, knockdown of USP10 increased the ubiquitination of WT AMPKalpha; on the other hand, knockdown of USP10 did not affect ubiquitination levels of the AMPKalpha 4KR mutan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26876938
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"We further overexpressed WT USP10 or CA mutant in USP10 deficient cells and found that WT USP10, but not the CA mutant, decreased ubiquitination of AMPKalpha, suggesting that USP10 regulates AMPKalpha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26876938
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"USP10 interacts with AMPK and deubiquitinates AMPKalpha."
26876938
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"In addition, in line with our study, two different groups have also reported that USP10 deubiquitinates and stabilizes PTEN and AMPKalpha in lung cancer and colon cancer cells [16, 27]."
30056112
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"Recently, it was established that USP10 deubiquitinates AMPKalpha to promote its interaction with LKB1, its master regulator and thus enhances its activity."
31481479
Modified USP10 leads to the deubiquitination of AMPK_alpha. 1 / 1
| 1
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"In contrast, overexpression of USP10 significantly inhibited polyubiquitylation of PTEN and AMPKalpha."
30056112
USP10 affects SIRT6
1 | 8
USP10 deubiquitinates SIRT6. 8 / 8
1 | 7
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"As previously mentioned, the peptidase USP10 de-ubiquitinates SIRT6, thereby protecting it from proteasomal degradation."
| PMC
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"USP10 suppresses SIRT6 ubiquitination to protect SIRT6 from proteasomal degradation."
24332849
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"In addition, Lin et al. demonstrated that USP10 enhanced the stability of SIRT6 through interacting with its N-terminal regulatory domain and deubiquitinating SIRT6, and then inhibited the transcriptional activity of the c-Myc oncogene through SIRT6 [25]."
35627217
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"USP10 deubiquitinates and stabilizes the tumor suppressor p53, and SIRT6."
27974222
ubibrowser
"Review"
27775833
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"Second, USP10 suppresses SIRT6 ubiquitination and protects SIRT6 from proteasome mediated degradation."
24332849
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"USP10 deubiquitinates and stabilizes SIRT6, which amplifies the tumor-suppressive activity of SIRT6."
24332849
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"USP10 negatively regulates SIRT6 ubiquitination."
24332849
Modified USP10 leads to the deubiquitination of SIRT6. 1 / 1
| 1
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"The results showed that overexpression of wild-type USP10 promoted the deubiquitination of Sirt6 and inhibited the activation of downstream Akt signaling pathway, while mutant USP10 lost this function."
33170082
USP10 affects IKBKG
1 | 6
USP10 deubiquitinates IKBKG. 7 / 7
1 | 6
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"By mediating USP10 dependent deubiquitination of NEMO, MCPIP1 serves in a negative feedback mechanism for attenuation of NF-kappaB activation [XREF_BIBR]."
27597804
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"One example is USP10 that requires the protein MCPIP-1 (monocyte chemotactic protein induced protein 1) to interact with and deubiquitinate its substrate NEMO inhibiting the NF-kappaB signalling cascade [XREF_BIBR]."
27597804
ubibrowser
"Review"
27775833
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"MCPIP1 induction serves as a negative feedback mechanism for attenuating NF-kappaB activation in genotoxic response by mediating USP10 dependent deubiquitination of NEMO [13]."
28951128
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"The USP10-dependent deubiquitination of NEMO and TRAF6 proteins is another strategy through which MCPIP1 can regulate inflammation and the immune response [34]."
33003343
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"USP10 deubiquitinates IKKgamma and NEMO, thereby inhibiting IKKgamma mediated nuclear factor kappaB (NF-kappaB) activation after genotoxic stress."
27974222
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"Thus, by mediating USP10 dependent deubiquitination of NEMO, MCPIP1 induction serves as a negative feedback mechanism for attenuating genotoxic NF-kappaB activation."
24270572
USP10 affects PTEN
1 | 5
USP10 deubiquitinates PTEN. 5 / 5
1 | 4
ubibrowser
"We further demonstrated that USP10 directly interacted with and stabilized PTEN via deubiquitination."
28852924
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"In addition, in line with our study, two different groups have also reported that USP10 deubiquitinates and stabilizes PTEN and AMPKalpha in lung cancer and colon cancer cells [16, 27]."
30056112
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"Additionally, we found that USP10 stabilized PTEN protein in a dose dependent manner, and inhibited Lys-48-linked polyubiquitylation of PTEN."
30056112
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"Furthermore, USP10 can also interact with and deubiquitinate PTEN, USP10 inhibition stimulates tumor growth and invasion, but this effect can be abolished by reinserting PTEN (Sun et al., 2018)."
30319415
reach
"In this study, we identified that USP10 can deubiquitinate PTEN and AMPKalpha and the stabilization of these two proteins will subsequently suppress the activation of AKT and mTOR in HCC cells."
30056112
Modified USP10 leads to the deubiquitination of PTEN. 1 / 1
| 1
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"In contrast, overexpression of USP10 significantly inhibited polyubiquitylation of PTEN and AMPKalpha."
30056112
USP10 affects PCNA
| 5
USP10 deubiquitinates PCNA. 5 / 5
| 5
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"Moreover, USP10 could induce PCNA deubiquitination to promote HCC cell growth."
34914965
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"Recent research has shown that PCNA is also modified by ISG15, and ISGylation of PCNA recruits USP10 to deubiquitinate PCNA, thereby regulating PCNA ubiquitination under UV irradiation induced stress."
28831681
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"And USP10 could strengthen cell proliferative and migratory abilities through deubiquitinating PCNA."
34914965
reach
"An interesting study has recently shown that the deubiquitylation of mammalian PCNA, at least in the context of DNA damage induced by ultraviolet irradiation (UV), is aided by the deubiquitylating activity of USP10."
29357069
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"This modification in turn recruits USP10 that de-ubiquitylates PCNA in order to block TLS and resume normal replication."
27379156
USP10 affects AICDA
| 5
USP10 deubiquitinates AICDA. 5 / 5
| 5
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"USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID."
34983926
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"l USP10 overexpression decreased AID ubiquitination."
34983926
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"k USP10 knockdown promoted AID ubiquitination."
34983926
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"As shown in Fig. 1e, k, knockdown of USP10 disrupted AID stability and increased AID ubiquitination."
34983926
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"Alternatively, the overexpression of USP10, but not its catalytically inactive CA mutant (C424A), stabilized AID and decreased the ubiquitination of AID (Fig. 1f, l) ."
34983926
USP10 affects YAP1
| 4
USP10 deubiquitinates YAP1. 4 / 4
| 4
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"In the context of HCC, USP10 promotes HCC cell proliferation and metastasis by deubiquitinating and stabilizing YAP and TAZ, the effector transcription factors of the Hippo signaling pathway, and SMAD4, the major signaling effector of TGFβ signaling [39,40,]."
34272356
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"USP10 depletion enhanced the polyubiquitination of YAP/TAZ, promoted their proteasomal degradation, and ultimately arrested the proliferation of hepatocellular carcinoma in vitro and in vivo [38]."
34315490
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"USP10 knockdown increased ubiquitination and degradation of YAP1, which further decreased the PD-L1 and Galectin-9 expression, suppressed immune escape, and reduced the proliferation and metastasis of PAAD cells in vitro and in vivo."
35271750
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"In conclusion, this work demonstrates that USP10 inhibits YAP1 ubiquitination and degradation to promote Cyr61 expression, which induces immune escape and promotes growth and metastasis of PAAD."
35271750
USP10 affects TRAF6
1 | 3
USP10 deubiquitinates TRAF6. 4 / 4
1 | 3
ubibrowser
"We found TANK formed a complex with MCPIP1 (also known as ZC3H12A) and a deubiquitinase, USP10, which was essential for the USP10-dependent deubiquitination of TRAF6 and the resolution of genotoxic NF-κB activation upon DNA damage."
25861989
reach
"The USP10-dependent deubiquitination of NEMO and TRAF6 proteins is another strategy through which MCPIP1 can regulate inflammation and the immune response [34]."
33003343
reach
"We found TANK formed a complex with MCPIP1 (also known as ZC3H12A) and a deubiquitinase, USP10, which was essential for the USP10 dependent deubiquitination of TRAF6 and the resolution of genotoxic NF-kappaB activation upon DNA damage."
25861989
reach
"TRAF Family Member associated NF-kappaB Activator (TANK) Inhibits Genotoxic Nuclear Factor kappaB Activation by Facilitating Deubiquitinase USP10 dependent Deubiquitination of TRAF6 Ligase."
25861989
USP10 affects TBP
1 | 3
USP10 deubiquitinates TBP. 3 / 3
1 | 2
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"To test whether USP10 deubiquitinates and stabilizes TBP in mammalian cells, we overexpressed USP10 in 293T cells and monitored TBP ubiquitination levels in these cells."
26393420
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"To test whether USP10 deubiquitinates TBP through direct protein protein interactions, we used HA-TBP to co-IP with Flag-USP10 co-expressed in 293T cells."
26393420
ubibrowser
"Huwe1 as an E3 ligase targeting TBP for K48-linked ubiquitination and proteasome-mediated degradation; We found that Huwe1 activity on TBP is antagonized by the deubiquitinase USP10, which protects TBP from degradation."
26393420
Modified USP10 leads to the deubiquitination of TBP. 1 / 1
| 1
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"Strikingly, overexpression of USP10 significantly inhibited TBP ubiquitination (XREF_FIG)."
26393420
USP10 affects NLRP7
| 1 3
USP10 deubiquitinates NLRP7. 4 / 4
| 1 3
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"Collectively, the present results indicated that NLRP7 in CRC cells interacts with and is deubiquitinated by USP10, resulting in increased NLRP7 protein stability."
33838681
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"NLRP7 deubiquitination by USP10 promotes tumor progression and tumor associated macrophage polarization in colorectal cancer."
33838681
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"Co-IP experiments showed that USP10 knockdown increased the ubiquitination of NLRP7 in HCT116 cells."
33838681
trips
"NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer."
33838681
USP10 affects FLT3
1 | 3
USP10 deubiquitinates FLT3. 2 / 2
1 | 1
ubibrowser
"USP10, a primary cytoplasmic DUB, acts as an oncogene or a tumor suppressor by regulating various protein substrates, including FLT3, p53, AMPK, PTEN, etc."
30319415
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"However, in acute myeloid leukemia (AML) patients with activating mutations in FMS‐like tyrosine kinase 3 (FLT3), USP10 deubiquitinates and stabilizes FLT3 by removing the proteolytic polyubiquitin chains and preventing FLT3 degradation, to aggravate tumor progress (Weisberg et al., 2017)."
31721429
USP10 leads to the deubiquitination of mutated FLT3. 2 / 2
| 2
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"In addition to mutant FLT3–ITD, another spleen tyrosine kinase (SYK), a critical regulator of FLT3, was deubiquitinated and stabilized by USP10; depleting or inhibiting USP10 reduced the expression of SYK, which promoted the proliferation of Ba/F3 and MOLM14 cells [68,84]."
35627217
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"Given our recent finding that USP10 deubiquitinates mutant FLT3, 18 coupled with reported studies showing that FLT3 and SYK are interacting partners with each other and are targets of the same E3 ligase c-CBL, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR we hypothesised that USP10 may play a role in stabilisation of SYK."
32015510
USP10 affects SKP2
| 3
USP10 deubiquitinates SKP2. 3 / 3
| 3
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"USP10 deubiquitinates and stabilizes SKP2."
31044085
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"Increased USP10 led to the deubiquitination and stabilization of SKP2, causing BCR-ABL activation and promoting CML cells’ proliferation [85,86]."
35627217
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"Additionally, Liao and colleagues [XREF_BIBR] found that USP10 can promote leukemic cell proliferation by deubiquitinating and stabilizing the S-phase kinase associated protein 2 (SKP2) that acts as a co-regulator of BCR-ABL mediating its K63 linked ubiquitination and activation in CML cells [XREF_BIBR]."
32674429
USP10 affects Histone
| 3
USP10 deubiquitinates Histone. 3 / 3
| 3
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"USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor mediated gene activation."
21245042
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"Moreover, USP10 not only binds AR, resulting in increased transcriptional activity, but also deubiquitinates the histone variant H2A.Z, both of which are required for AR - mediated gene activation [XREF_BIBR, XREF_BIBR]."
29353883
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"In addition, more bulky structures, SUMO (small ubiquitin related modifier) and ubiquitin are conjugated to histones (Galanty et al., 2009; Morris et al., 2009; Shioo and Eisenman, 2003; Thakar et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22155569
USP10 affects His2Av
| 3
USP10 deubiquitinates His2Av. 3 / 3
| 3
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"USP10 specifically deubiquitylates H2A.Z and H2A."
21245042
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"In addition, the deubiquitination of H2A.Z by USP10 is required for the androgen-receptor mediated transcriptional activation of hormone regulated genes [XREF_BIBR]."
29495465
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"USP10 directly deubiquitylates H2A.Z in vitro and in vivo, and reducing USP10 expression in prostate cancer cells results in elevated steady-state levels of mono-ubiquitylated H2A.Z (H2A.Zub1)."
21245042
USP10 affects HDAC6
| 3
USP10 deubiquitinates HDAC6. 3 / 3
| 3
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"Next, we tested whether USP10 could deubiquitinate HDAC6."
32382008
reach
"Another previous study from Hu et al. also showed that the depletion of USP10 increased the K48-linked polyubiquitination of HDAC6 in the non-small-cell lung cancer (NSCLC) cell line H1299."
35627217
reach
"XREF_FIG, wild-type USP10, but not the catalytically-inactive USP10CA mutant, significantly reduces HDAC6 ubiquitination in 293T cells (comparing lanes 3 and 4 in the top panel)."
32382008
USP10 affects H2Aub1
| 3
USP10 deubiquitinates H2Aub1. 3 / 3
| 3
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"AR-related proteins including H2A, Zub1, and H2Aub1 can be deubiquitinated and stabilized by USP10."
35627217
reach
"Indeed, in this study, we found that USP10 deubiquitylates H2A.Zub1 and H2Aub1 in vitro and in vivo."
21245042
reach
"Co-transfection studies showed that USP10 specifically deubiquitylates H2A.Zub1 and H2Aub1, but not H2Bub1, in a dose dependent manner."
21245042
USP10 affects mUb-PCNA
| 2
USP10 deubiquitinates mUb-PCNA. 2 / 2
| 2
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"Although Poleta reduced affinity for the DNA beyond the CPD might contribute to its dissociation after TLS 28, deubiquitination of mUb-PCNA by USP1 29 or USP10 30 can promote Poleta displacement from replication forks."
29208956
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"Moreover, deubiquitination of mUb-PCNA by USP1 29, USP10 30, or interferon stimulated gene 15 modification of PCNA has also been suggested to dictate TLS termination 30."
29208956
USP10 affects TOP2alpha
| 2
USP10 deubiquitinates TOP2alpha. 2 / 2
| 2
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"USP10 deubiquitylates TOP2alpha and restrains its chromatin binding."
27558965
reach
"We also identified USP10 as an interacting partner for RNF168 and TOP2alpha, and provide evidence that USP10 deubiquitylates TOP2alpha and negatively regulates its chromatin binding (XREF_FIG)."
27558965
USP10 affects TAFAZZIN
| 2
USP10 deubiquitinates TAFAZZIN. 2 / 2
| 2
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"In the context of HCC, USP10 promotes HCC cell proliferation and metastasis by deubiquitinating and stabilizing YAP and TAZ, the effector transcription factors of the Hippo signaling pathway, and SMAD4, the major signaling effector of TGFβ signaling [39,40,]."
34272356
reach
"USP10 depletion enhanced the polyubiquitination of YAP/TAZ, promoted their proteasomal degradation, and ultimately arrested the proliferation of hepatocellular carcinoma in vitro and in vivo [38]."
34315490
USP10 affects SMAD4
| 2
USP10 deubiquitinates SMAD4 on lysine. 1 / 1
| 1
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"These data collectively demonstrate that USP10 deubiquitinates and stabilizes Smad4 through the cleavage of Lys‐K48‐linked polyubiquitin chain from Smad4, thus preventing its proteasomal degradation.3.5 USP10 depletion inhibits HCC metastasis through down-regulation of Smad4."
31721429
USP10 deubiquitinates SMAD4. 1 / 1
| 1
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"We found that USP10 plays a key role in the metastasis of advanced HCC by deubiquitinating and stabilizing Smad4, a vital transcriptional factor of TGF‐β signaling."
31721429
USP10 affects RPS3
1 | 1
USP10 deubiquitinates RPS3. 2 / 2
1 | 1
ubibrowser
No evidence text available
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"Subsequent deubiquitination of RPS2 and RPS3 by USP10 is critical for recycling of stalled ribosomes in a process known as ribosome associated quality control."
34348161
USP10 affects MSH2
1 | 1
USP10 deubiquitinates MSH2. 2 / 2
1 | 1
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"USP10 deubiquitinates MSH2 in vitro and in vivo Moreover, the protein level of MSH2 is positively correlated with the USP10 protein level in a panel of lung cancer cell lines."
26975374
ubibrowser
"Here we report that ubiquitin-specific peptidase 10 (USP10) interacts with and stabilizes MSH2."
26975374
USP10 affects MDM2
| 2
USP10 deubiquitinates MDM2. 2 / 2
| 2
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"Another DUB, USP10 deubiquitinates p53, but not MDM2 or MDMX."
29479529
reach
"USP10 (a cytosolic deubiquitinating enzyme) with an affinity for p53 reverses Mdm2-mediated ubiquitination, cytoplasmatic degradation, and nuclear export and impacts the transcriptional activity of p53 (Sun and Dai, 2014)."
34744708
USP10 affects MAPT
| 1 1
USP10 deubiquitinates MAPT. 2 / 2
| 1 1
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"USP10 deubiquitinates Tau, mediating its aggregation."
35987808
trips
"USP10 deubiquitinates Tau, mediating its aggregation."
35987808
USP10 affects LC3B
| 2
USP10 deubiquitinates LC3B. 2 / 2
| 2
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"The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity."
33577797
reach
"Herein, we report that LC3B ubiquitination is reversed by the action of the deubiquitinating enzyme USP10."
33577797
USP10 affects H2A.Zub1
| 2
USP10 deubiquitinates H2A.Zub1. 2 / 2
| 2
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"Indeed, in this study, we found that USP10 deubiquitylates H2A.Zub1 and H2Aub1 in vitro and in vivo."
21245042
reach
"Co-transfection studies showed that USP10 specifically deubiquitylates H2A.Zub1 and H2Aub1, but not H2Bub1, in a dose dependent manner."
21245042
USP10 affects ENaC
| 2
USP10 deubiquitinates ENaC. 2 / 2
| 2
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"USP10, in particular, deubiquitinates ENaC and CFTR increasing their expression in cell membrane."
33095475
reach
"Yet, overexpressed USP10 does not deubiquitinate the bulk of the ENaC pool."
21955996
USP10 affects CDKN2A
1 | 1
USP10 leads to the deubiquitination of CDKN2A. 2 / 2
1 | 1
ubibrowser
"Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF."
29472714
reach
"USP10, in turn, mediated the deubiquitination of p14ARF, preventing its proteasome dependent degradation."
29472714
USP10 affects gJ
| 1
USP10 leads to the deubiquitination of gJ. 1 / 1
| 1
reach
"USP10 antagonizes RNF10-dependent uS3 and uS5 ubiquitylation."
34469731
USP10 affects ULK1
| 1
USP10 deubiquitinates ULK1. 1 / 1
| 1
reach
"However, a direct deubiquitination of ULK1 by USP10 remains to be demonstrated."
26445063
USP10 affects TOP2A
| 1
USP10 deubiquitinates TOP2A. 1 / 1
| 1
reach
"In contrast, USP10, also a cytosolic DUB [XREF_BIBR], deubiquitylates TOP2A in complex with the E3 ligase RNF168 [XREF_BIBR], which is also important in DNA damage response signalling for double-strand break repair [XREF_BIBR]."
29429988
USP10 affects TGF‐β
| 1
USP10 deubiquitinates TGF‐β. 1 / 1
| 1
reach
"We found that USP10 plays a key role in the metastasis of advanced HCC by deubiquitinating and stabilizing Smad4, a vital transcriptional factor of TGF‐β signaling."
31721429
USP10 affects TBX21
1 |
USP10 deubiquitinates TBX21. 1 / 1
1 |
USP10 affects TAP1
1 |
USP10 deubiquitinates TAP1. 1 / 1
1 |
USP10 affects SYK
| 1
USP10 deubiquitinates SYK. 1 / 1
| 1
reach
"In addition to mutant FLT3–ITD, another spleen tyrosine kinase (SYK), a critical regulator of FLT3, was deubiquitinated and stabilized by USP10; depleting or inhibiting USP10 reduced the expression of SYK, which promoted the proliferation of Ba/F3 and MOLM14 cells [68,84]."
35627217
USP10 affects SOX21
| 1
USP10 deubiquitinates SOX21. 1 / 1
| 1
reach
"Through mechanism assays, we uncovered that SOX21-AS1 sponged SOX21-AS1 to elevate SOX21 mRNA and recruited ubiquitin-specific peptidase 10 (USP10) to deubiquitinate and stabilize SOX21 protein."
36335356
USP10 affects SNX3
1 |
USP10 deubiquitinates SNX3. 1 / 1
1 |
ubibrowser
"?A two-hybrid screen identified sorting nexin 3 (SNX3) as a novel substrate of Usp10."
18632802
USP10 affects SNAI2
1 |
USP10 deubiquitinates SNAI2. 1 / 1
1 |
ubibrowser
"Here, by using a genome wide siRNA screen for human deubiquitinating enzymes (DUBs), we identified USP10 as a deubiquitinase for Slug in cancer cells."
29803676
USP10 affects SLC9A3
| 1
USP10 leads to the deubiquitination of SLC9A3. 1 / 1
| 1
reach
"Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity."
33095475
USP10 affects SERPINE2
| 1
USP10 deubiquitinates SERPINE2. 1 / 1
| 1
reach
"Additionally, USP10 indirectly regulates ENaC by deubiquitinating soring nexin 3."
33095475
USP10 affects Rsp3p
| 1
USP10 deubiquitinates Rsp3p. 1 / 1
| 1
reach
"In fact, USP10 deubiquitinates the Rsp3p to stall active translation."
31481479
USP10 affects RUNX1
| 1
USP10 deubiquitinates RUNX1. 1 / 1
| 1
reach
"USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma."
36949071
USP10 affects RPS2
| 1
USP10 deubiquitinates RPS2. 1 / 1
| 1
reach
"Subsequent deubiquitination of RPS2 and RPS3 by USP10 is critical for recycling of stalled ribosomes in a process known as ribosome associated quality control."
34348161
USP10 affects RPS125
| 1
USP10 deubiquitinates RPS125 on S60. 1 / 1
| 1
reach
"Peter and his group reported that deubiquitination of RPS125 by USP10 and Ubp3p-BRE 5/Bre5p activity triggers 60S ribosome uptake and degradation by autophagosomes under nitrogen starvation."
31481479
USP10 affects RNF10
| 1
USP10 leads to the deubiquitination of RNF10. 1 / 1
| 1
reach
"USP10 antagonizes RNF10-dependent uS3 and uS5 ubiquitylation."
34469731
USP10 affects PRKAA2
1 |
USP10 deubiquitinates PRKAA2. 1 / 1
1 |
ubibrowser
"The deubiquitinase USP10 specifically removes ubiquitination on AMPKalpha to facilitate AMPKalpha phosphorylation by LKB1."
26876938
USP10 affects PRKAA1
1 |
USP10 deubiquitinates PRKAA1. 1 / 1
1 |
ubibrowser
"The deubiquitinase USP10 specifically removes ubiquitination on AMPKa to facilitate AMPKa phosphorylation by LKB1."
26876938
USP10 affects PDLIM5
| 1
USP10 deubiquitinates PDLIM5. 1 / 1
| 1
reach
"Research on the endothelium revealed that USP10, as a regulatory protein, delayed the rate of NICD1 degradation by deubiquitinating the Notch1 receptor (Lim et al., 2019)."
34957094
USP10 affects Nucleoproteins
| 1
USP10 deubiquitinates Nucleoproteins. 1 / 1
| 1
reach
"The result showed that both USP10 and USP11 specifically co-precipitated with NP-HA (lanes 1, 3 and 4, lower panel), consistent with the published result, and NP could be deubiquitinated by only USP11 but not USP10 (lanes 3 and 4, upper panel)."
20924359
USP10 affects Notch1 receptor
| 1
USP10 deubiquitinates Notch1 receptor. 1 / 1
| 1
reach
"Research on the endothelium revealed that USP10, as a regulatory protein, delayed the rate of NICD1 degradation by deubiquitinating the Notch1 receptor (Lim et al., 2019)."
34957094
USP10 affects NOTCH1
| 1
USP10 deubiquitinates NOTCH1. 1 / 1
| 1
reach
"Research on the endothelium revealed that USP10, as a regulatory protein, delayed the rate of NICD1 degradation by deubiquitinating the Notch1 receptor (Lim et al., 2019)."
34957094
USP10 affects MutS Homolog 2
| 1
USP10 deubiquitinates MutS Homolog 2. 1 / 1
| 1
reach
"Ubiquitin specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutS Homolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage."
26975374
USP10 affects MDM4
| 1
USP10 deubiquitinates MDM4. 1 / 1
| 1
reach
"Another DUB, USP10 deubiquitinates p53, but not MDM2 or MDMX."
29479529
USP10 affects ITGB5
1 |
USP10 deubiquitinates ITGB5. 1 / 1
1 |
ubibrowser
"?Silencing of the DUB USP10 induces a buildup of ubiquitin on integrins beta1 and beta5 in cell lysates, whereas recombinant USP10 removes ubiquitin from these integrin subunits."
28851806
USP10 affects ITGB1
1 |
USP10 deubiquitinates ITGB1. 1 / 1
1 |
ubibrowser
"?Silencing of the DUB USP10 induces a buildup of ubiquitin on integrins beta1 and beta5 in cell lysates, whereas recombinant USP10 removes ubiquitin from these integrin subunits."
28851806
USP10 affects H2Bub1
| 1
USP10 deubiquitinates H2Bub1. 1 / 1
| 1
reach
"Co-transfection studies showed that USP10 specifically deubiquitylates H2A.Zub1 and H2Aub1, but not H2Bub1, in a dose dependent manner."
21245042
USP10 affects H2BC10
1 |
USP10 deubiquitinates H2BC10. 1 / 1
1 |
ubibrowser
"The deubiquitinase (DUB) Ubp10 is thought to promote heterochromatic silencing by maintaining low H2B-Ub at sub-telomeres"
29288197
USP10 affects H2AZ1
1 |
USP10 deubiquitinates H2AZ1. 1 / 1
1 |
USP10 affects ARF
| 1
USP10 deubiquitinates ARF. 1 / 1
| 1
reach
"USP10 deubiquitinates ARF by interacting with the N-terminus of ARF, thereby stabilizing the ARF protein by blocking the proteasome-mediated ARF degradation."
32759846
USP10 affects AR
| 1
USP10 deubiquitinates AR. 1 / 1
| 1
reach
"Together, these data provide novel insights into how H2A.Z ubiquitylation and deubiquitylation and USP10 function in AR regulated gene expression."
21245042
USP10 affects AMPK
| 1
USP10 deubiquitinates AMPK. 1 / 1
| 1
reach
"Deubiquitination and activation of AMPK by USP10."
26876938