IndraLab

Statements

OTULIN affects polyubiquitin chain
| 2
OTULIN deubiquitinates polyubiquitin chain. 2 / 2
| 2
reach
"Mechanistic studies showed that, upon TNFalpha stimulation, OTULIN-SNX27 is localised to membrane associated TNF receptor complex, where OTULIN deubiquitinates the linear polyubiquitin chain that formed by the LUBAC complex."
34315543
reach
"Mechanistic studies showed that, upon TNFalpha stimulation, OTULIN-SNX27 is localised to membrane associated TNF receptor complex, where OTULIN deubiquitinates the linear polyubiquitin chain that formed by the LUBAC complex."
| PMC
OTULIN affects RNF31
| 2
Modified OTULIN-C129A leads to the deubiquitination of RNF31 on M1. 1 / 1
| 1
reach
"We have previously shown that knockdown of OTULIN or overexpression of a catalytically inactive OTULIN C129A mutant (CA) lead to the autoubiquitination of HOIP with Met1 linked polyUb chains (XREF_FIG A, compare lanes 1 and 4; XREF_FIG B, compare lanes 1 and 2)."
24726323
OTULIN leads to the deubiquitination of RNF31. 1 / 1
| 1
reach
"This observation suggests that, under basal conditions, the binding of OTULIN prevents HOIP autoubiquitination."
24726323
OTULIN affects STAT1
| 1
OTULIN leads to the deubiquitination of STAT1. 1 / 1
| 1
reach
"Knockdown of OTULIN upregulated linear ubiquitination of cellular STAT1 (Fig. 5c)."
32123171
OTULIN affects RIPK2
| 1
OTULIN deubiquitinates RIPK2 on M1. 1 / 1
| 1
reach
"OTULIN was shown to limit M1-linked ubiquitination of RIPK2 and antagonize LUBAC after NOD2 activation and subsequent NF-κB and MAPK signaling (Fiil et al., 2013)."
31632962
OTULIN affects RIPK1
| 1
OTULIN leads to the deubiquitination of RIPK1. 1 / 1
| 1
reach
"OTULIN reduced ubiquitination of both, caspase-8 and RIPK1, identifying RIPK1 and caspase-8 as linearly ubiquitinated proteins (Fig XREF_FIG A)."
28258062
OTULIN affects Proteasome
| 1
OTULIN deubiquitinates Proteasome. 1 / 1
| 1
reach
"Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production."
34797715
OTULIN affects OTULINL
| 1
OTULIN deubiquitinates OTULINL. 1 / 1
| 1
reach
"Intriguingly, the OTULIN pseudo deubiquitinating enzyme FAM105A (OTULINL) shares ~ 33% amino acid sequence identity with OTULIN, but lacks Met1 Ub catalytic activity or the ability to interact with Ub or LUBAC [XREF_BIBR, XREF_BIBR]."
33288901
OTULIN affects NLRP6
| 1
OTULIN deubiquitinates NLRP6. 1 / 1
| 1
reach
"Cyld cleaved Ub chains from NLRP6 (XREF_FIG, top blot, lane 2) and released Ub (XREF_FIG, bottom blot, lane 2), whereas otulin failed to deubiquitinate NLRP6 (XREF_FIG, top blot, lane 3)."
32424362
OTULIN affects IRF3
| 1
OTULIN deubiquitinates IRF3. 1 / 1
| 1
reach
"The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3."
34545182
OTULIN affects IKBKG
1 |
OTULIN deubiquitinates IKBKG. 1 / 1
1 |
ubibrowser
"Deubiquitination effects of swine OTULIN were identified. The interaction between porcine OTULIN and PRRSV Nsp11 is dependent on the OTU domain. PRRSV Nsp11 recruits OTULIN through a nonenzymatic combination to promote removal of linear ubiquitination targeting NEMO, resulting in a superimposed effect that inhibits the production of type I IFNs."
29444948
OTULIN affects CASP8
| 1
OTULIN leads to the deubiquitination of CASP8. 1 / 1
| 1
reach
"OTULIN reduced ubiquitination of both, caspase-8 and RIPK1, identifying RIPK1 and caspase-8 as linearly ubiquitinated proteins (Fig XREF_FIG A)."
28258062
OTULIN affects ACVRL1
| 1
OTULIN deubiquitinates ACVRL1. 1 / 1
| 1
reach
"Conversely, OTULIN deubiquitinates ALK1 to promote Smad1/5 activation."
34157307