IndraLab

Statements

OTUD7B affects ZAP70
1 | 7
OTUD7B deubiquitinates ZAP70. 6 / 6
1 | 5
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"OTUD7B has been shown to antagonize ZAP70 ubiquitination, which prevents association with STS1 and STS2."
28524749
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"Otud7b binds to and deubiquitinates Zap70."
26903241
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"Importantly, the Otud7b deficiency substantially enhanced the ubiquitination of Zap70 (XREF_FIG), and the Otud7b knockdown in EL4 cells also enhanced the TCR-CD28-stimulated Zap70 ubiquitination (XREF_FIG)."
26903241
reach
"Otud7b binds to and deubiquitinates Zap70, thereby preventing the interaction of Zap70 with the negative-regulatory phosphatases, Sts1 and Sts2 199 (XREF_FIG)."
27012466
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"86 A DUB, Otud7b, deubiquitinates ZAP70 to prevent its association with Sts1 and Sts2, thereby positively regulating TCR signaling."
33436547
ubibrowser
"Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination"
26903241
OTUD7B deubiquitinates ZAP70 on K544. 2 / 2
| 2
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"Mechanistically, Otud7b deubiquitinated Zap70 at K544."
29685903
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"Otud7b likely opposes the action of a Zap70 E3 ligase other than Nrdp1, because Otud7b inhibits Zap70 ubiquitination mainly at K544, which differs from the Nrdp1 target site (K538)."
26903241
OTUD7B affects TRAF3
1 | 1 5
OTUD7B deubiquitinates TRAF3. 3 / 3
1 | 1 1
ubibrowser
"OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3"
23334419
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"In response to noncanonical NF-kappaB stimuli, Otud7b binds and deubiquitinates TRAF3, thereby inhibiting TRAF3 proteolysis and preventing aberrant noncanonical NF-kappaB activation."
23334419
trips
"OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3."
33198776
OTUD7B-C194S deubiquitinates TRAF3. 1 / 1
| 1
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"The Otud7b mediated TRAF3 deubiquitination required its DUB activity since a catalytically inactive Otud7b mutant, C194S and H358R (CH), failed to deubiquitinate TRAF3 (XREF_FIG)."
23334419
Modified OTUD7B leads to the deubiquitination of TRAF3. 1 / 1
| 1
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"The loss of Otud7b promoted anti-CD40-stimulated TRAF3 ubiquitination (XREF_FIG)."
23334419
OTUD7B-H358R deubiquitinates TRAF3. 1 / 1
| 1
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"The Otud7b mediated TRAF3 deubiquitination required its DUB activity since a catalytically inactive Otud7b mutant, C194S and H358R (CH), failed to deubiquitinate TRAF3 (XREF_FIG)."
23334419
Mutated OTUD7B deubiquitinates TRAF3. 1 / 1
| 1
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"The Otud7b mediated TRAF3 deubiquitination required its DUB activity since a catalytically inactive Otud7b mutant, C194S and H358R (CH), failed to deubiquitinate TRAF3 (XREF_FIG)."
23334419
OTUD7B affects KDM1A
| 6
OTUD7B deubiquitinates KDM1A. 5 / 5
| 5
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"Conversely, OTUD7B depletion remarkably enhanced polyubiquitination of endogenous LSD1 (Figure 2B)."
34050636
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"To assess the types of Ub‐linkage that OTUD7B may catalyze when deubiquitinates LSD1, we utilized two Ub mutants, K48 and K63."
34050636
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"OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis."
34050636
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"Therefore, perturbation of OTUD7B–LSD1 axis results in changes in both activating and repressive chromatin modification marks, providing a plausible mechanism for altered gene transcription due to OTUD7B loss.To investigate the contribution of LSD1 deubiquitination by OTUD7B in OTUD7B‐mediated LSD1 genomic distribution and H3K4me2/H3K9me2 enrichment, we analyzed LSD1 binding and H3K4me2/H3K9me2 levels of the selected 11 genes in LSD1 reconstituting cells."
34050636
reach
"As shown in Figure S3A in the Supporting Information, K63R mutation caused significant loss of polyubiquitinated LSD1 signals, whereas K48R displayed very marginal reduction in LSD1 ubiquitination, suggesting LSD1 ubiquitination involves mixed linkage specificity, and predominantly prefers K63‐linked polyubiquitin chains.We next determined whether OTUD7B modulated LSD1 deubiquitination."
34050636
OTUD7B leads to the deubiquitination of KDM1A on K63. 1 / 1
| 1
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"OTUD7B deficiency increases K63-linked ubiquitination of LSD1, which disrupts LSD1/CoREST complex formation and targets LSD1 for p62-mediated proteolysis."
34050636
OTUD7B affects EGFR
1 | 4
OTUD7B deubiquitinates EGFR. 5 / 5
1 | 4
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"OTUD7B deubiquitinated EGFR and facilitates downstream pathway MAPK."
31747939
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"Therefore, we hypothesized that OTUD7B may deubiquitinate EGFR and activate downstream pathway MAPK."
31747939
ubibrowser
"USP21 and Cezanne or OTUD7B negatively regulate NFκB signaling by deubiquitinating and inactivating RIP1 upon TNF-α?stimulation, providing a feedback loop in the proinflammatory signaling"
25121098
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"Ultimately, OTUD7B mediates EGFR deubiquitination and stability and MAPK signaling pathway activation, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a feasible therapeutic target for PC."
31747939
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"Therefore, we found that Linc00976 promoted proliferation and invasion via MAPK pathway, which is activated by OTUD7B mediated EGFR deubiquitination and stability.However, the mechanism of linc00976 regulating OTUD7B expression was still not clear."
31747939
OTUD7B affects RIPK1
1 1 | 1
OTUD7B leads to the deubiquitination of RIPK1. 2 / 2
1 | 1
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"OTUD7B, a newly identified member of the A20 family of DUBs, inhibits RIP1 ubiquitination and downstream IKK activity and NF-kappaB signalling [XREF_BIBR]."
25595906
ubibrowser
"USP21 and Cezanne or OTUD7B negatively regulate NFκB signaling by deubiquitinating and inactivating RIP1 upon TNF-α?stimulation, providing a feedback loop in the proinflammatory signaling"
25121098
OTUD7B deubiquitinates RIPK1 on K377. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7B affects TRAF6
1 | 1
OTUD7B leads to the deubiquitination of TRAF6. 2 / 2
1 | 1
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"These data indicate that endogenous Cezanne suppresses TRAF6 polyubiquitination in response to hypoxia-reoxygenation."
23564640
ubibrowser
"Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination"
23564640
OTUD7B affects SQSTM1
| 2
OTUD7B deubiquitinates SQSTM1. 2 / 2
| 2
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"OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity."
35100065
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"OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity."
35100065
OTUD7B affects KLF4
| 2
OTUD7B deubiquitinates KLF4. 2 / 2
| 2
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"These data indicated that OTUD7B interacts with and deubiquitylates KLF4 and OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels."
32685020
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"As anticipated, co-immunoprecipitation experiments revealed that OTUD7B interacted with and deubiquitylated KLF4."
32685020
OTUD7B affects YAP1
| 1
OTUD7B deubiquitinates YAP1. 1 / 1
| 1
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"OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession."
37429790
OTUD7B affects OTUD7B
| 1
OTUD7B deubiquitinates OTUD7B. 1 / 1
| 1
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"These data indicated that OTUD7B interacts with and deubiquitylates KLF4 and OTUD7B downregulation by Sal-miR-1 and 3 attenuates KLF4 protein levels."
32685020
OTUD7B affects NFkappaB
| 1
OTUD7B leads to the deubiquitination of NFkappaB. 1 / 1
| 1
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"OTUD7B, a newly identified member of the A20 family of DUBs, inhibits RIP1 ubiquitination and downstream IKK activity and NF-kappaB signalling [XREF_BIBR]."
25595906
OTUD7B affects MLST8
| 1
OTUD7B leads to the deubiquitination of MLST8. 1 / 1
| 1
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"In addition, our integrative analysis demonstrates that ubiquitination of MLST8, which is reversed by OTUD7B, is regulated by IRS1/2."
34529665
OTUD7B affects MAP3K14
| 1
OTUD7B deubiquitinates MAP3K14. 1 / 1
| 1
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"Given that OTUD7B specifically regulates the NF-kappaB2 pathway and TRAF3 degradation, it would be of interest to determine if OTUD7B also deubiquitinates NIK."
26085206
OTUD7B affects IKK_complex
| 1
OTUD7B leads to the deubiquitination of IKK_complex. 1 / 1
| 1
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"OTUD7B, a newly identified member of the A20 family of DUBs, inhibits RIP1 ubiquitination and downstream IKK activity and NF-kappaB signalling [XREF_BIBR]."
25595906
OTUD7B affects HIF1A
| 1
OTUD7B deubiquitinates HIF1A. 1 / 1
| 1
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"For example, OTU deubiquitinase 7B (OTUD7B) can deubiquitinate HIF-1alpha and inhibit its degradation by the lysosome."
32140262
OTUD7B affects GbetaL
| 1
OTUD7B leads to the deubiquitination of GbetaL. 1 / 1
| 1
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"Deletion of Otud7b did not significantly affect Akt ubiquitination, but largely abolished the decrease of GbetaL ubiquitination in cells induced by growth factor stimulation (XREF_FIG and XREF_FIG)."
28489822
OTUD7B affects CDC16
1 |
OTUD7B deubiquitinates CDC16. 1 / 1
1 |
ubibrowser
"Here, we demonstrate that Cezanne/OTUD7B is a cell cycle-regulated DUB that opposes the ubiquitination of APC/C targets."
29973362