IndraLab

Statements

MYSM1 affects His2A
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MYSM1 deubiquitinates His2A. 2 / 2
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"In contrast, there was no apparent difference in ubH2A in EBF1 promoter desert region (PDR) and exon 2 regions, as well as in the osteocalcin (OC) promoter locus of WT and Mysm1 -/- Lin - progenitors, suggesting the selective deubiquitination of uH2A at the Ebf1 locus by MYSM1."
22169041
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"Significantly, although cells were treated with DHT as usual, the amount of pS5-Pol II on the promoter was reduced upon loss of 2A-DUB and increased levels of uH2A, which argues that 2A-DUB and result[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
MYSM1 affects ubH2A
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MYSM1 deubiquitinates ubH2A. 1 / 1
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"Collectively, these data indicate that MYSM1 not only deubiquitinates ubH2A, but also orchestrates histone modifications at the Ebf1 locus and that its deficiency results in the repressive histone modifications and impaired recruitment of the key transcription factors to the Ebf1 locus."
22169041
MYSM1 affects Histone_H2A
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MYSM1 deubiquitinates Histone_H2A. 1 / 1
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"MYSM1, a member of the JAMM family, is a histone DUB which specifically deubiquitinates histone 2A [129]."
30123285
MYSM1 affects H2AK119
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MYSM1 deubiquitinates H2AK119. 1 / 1
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"To confirm that the observed up-regulation of lamin A/C was due to specific knockdown of Ring1 or Rnf2 rather than off-target effects, we overexpressed Mysm1, which deubiquitinates H2AK119 in opposition to Ring1 and Rnf2."
30072429
MYSM1 affects H2AC20
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MYSM1 deubiquitinates H2AC20. 1 / 1
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ubibrowser
"Myb-Like, SWIRM, and MPN domains 1 (MYSM1) is a metalloprotease that deubiquitinates the K119-monoubiquitinated form of histone 2A (H2A), a chromatin marker associated with gene transcription silencing."
26220525
MYSM1 affects H2AC17
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MYSM1 deubiquitinates H2AC17. 1 / 1
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