IndraLab

Statements

BRCC3 affects NLRP3
| 35
BRCC3 deubiquitinates NLRP3. 10 / 33
| 33
reach
"Lys-63-specific deubiquitinase BRCC36 (BRCC3), a JAMM domain containing Zn 2+ metalloprotease, promotes NLRP3 deubiquitination during priming and regulates NLRP3 activation [26]."
27669650
reach
"Viral RNA (vRNA) molecule-induced NLRP3 inflammasome activation also comes about by post-translational priming, but involving the RIP1/caspase 8/RIP3 signaling pathway (29, 45), which may ultimately result in the deubiquitination of NLRP3 protein by BRCC3 (46, 47)."
29163496
reach
"The K-63-specific deubiquitinating enzyme BRCC3 mediates the deubiquitylation of NLRP3, which has recently been shown to occur in response to pattern recognition receptor stimulation [XREF_BIBR]."
29120406
reach
"BRCC3 inhibition promotes NLRP3 ubiquitination and blocks inflammasome assembly but does not target NLRP3 for degradation."
30288079
reach
"By screening a deubiquitinating enzyme (DUB) library, they recognized that BRCC3 (BRCA1, BRCA2, and containing complex subunit 3) deubiquitinates the LRR domain of NLRP3, which then proceeds NLRP3 activation 59."
30755589
reach
"A posttranscriptional modification, such as NLRP3 deubiquitination mediated by BRCA1/BRCA2-containing complex subunit 3 (BRCC3), is required for NLRP3 activation (signal 2) [67, 68]."
31687078
reach
"For example, breast cancer 1 (BRCA1)/breast cancer 2 (BRCA2)-containing complex subunit 3 (BRCC3) deubiquitinates NLRP3, and pharmaceutical inhibition of DUBs restricts inflammasome activation [79,112,113], whereas E3 ubiquitin ligases LUBAC and TRIM33 promote inflammasome assembly [114,115]."
27783058
reach
"Py et al. found that BRCC3 promotes NLRP3 inflammasome activation by deubiquitinating the LRR domain of NLRP3 50."
25762778
reach
"Recently, BRCC3 in the cytosol has been reported to promote the inflammasome activation by deubiquitinating NLRP3 in LPS primed macrophages [XREF_BIBR]."
25337721
reach
"A subsequent study identified that the deubiquitinating enzyme, BRCC3, mediates the deubiquitination of NLRP3 [27]."
32545355
Modified BRCC3 leads to the deubiquitination of NLRP3. 1 / 1
| 1
reach
"In addition, consistent with its role as a deubiquitination enzyme for NLRP3, BRCC3 expression significantly reduced the extent of NLRP3 covalent ubiquitination in 293T cells."
23246432
BRCC3 deubiquitinates NLRP3 at position 153. 1 / 1
| 1
reach
"Besides phosphorylation, the deubiquitinating enzyme BRCA1/BRCA2-containing complex subunit 3 (BRCC3) promotes an inflammasome activation by deubiquitinating NLRP3 at its LRR domain 153 ."
32550001
BRCC3 affects interferon receptor
| 3
BRCC3 deubiquitinates interferon receptor. 3 / 3
| 3
reach
"The Abraxas complex (ARISC) functions in DNA repair and breast cancer suppression, while the BRCC36 isopeptidase complex (BRISC) promotes interferon dependent responses by deubiquitinating and stabilizing the type I interferon receptor, IFNAR1."
26344097
reach
"In the BRCC36 isopeptidase complex, BRCC36 promotes interferon dependent responses by deubiquitinating and stabilizing the type I interferon receptor XREF_BIBR."
27774986
reach
"Dr. Greenberg group from University of Pennsylvania showed that BRCC36 containing deubiquitinating complex BRISC which is also a sister protein complex of nuclear RAP80-BRCA1 complex, deubiquitinates type I interferon receptor (IFNAR1), resulting in its delayed lysosomal dependent degradation."
27211605
BRCC3 affects NACHT
| 3
BRCC3 leads to the deubiquitination of NACHT on K64. 1 / 1
| 1
reach
"Recently, Py and colleagues demonstrated that BRCC3, a JAMM domain containing zinc metalloprotease DUB, promotes NLRP3 inflammasome activation by deubiquitinating the mixed K64 and K48 ubiquitin chains on both the NACHT and LRR domains of NLRP3 [XREF_BIBR]."
25698849
BRCC3 leads to the deubiquitination of NACHT. 1 / 1
| 1
reach
"Recently, Py and colleagues demonstrated that BRCC3, a JAMM domain containing zinc metalloprotease DUB, promotes NLRP3 inflammasome activation by deubiquitinating the mixed K64 and K48 ubiquitin chains on both the NACHT and LRR domains of NLRP3 [XREF_BIBR]."
25698849
BRCC3 leads to the deubiquitination of NACHT on K48. 1 / 1
| 1
reach
"Recently, Py and colleagues demonstrated that BRCC3, a JAMM domain containing zinc metalloprotease DUB, promotes NLRP3 inflammasome activation by deubiquitinating the mixed K64 and K48 ubiquitin chains on both the NACHT and LRR domains of NLRP3 [XREF_BIBR]."
25698849
BRCC3 affects Interferon
| 3
BRCC3 deubiquitinates Interferon. 3 / 3
| 3
reach
"Dr. Greenberg group from University of Pennsylvania showed that BRCC36 containing deubiquitinating complex BRISC which is also a sister protein complex of nuclear RAP80-BRCA1 complex, deubiquitinates type I interferon receptor (IFNAR1), resulting in its delayed lysosomal dependent degradation."
27211605
reach
"In the BRCC36 isopeptidase complex, BRCC36 promotes interferon dependent responses by deubiquitinating and stabilizing the type I interferon receptor XREF_BIBR."
27774986
reach
"The Abraxas complex (ARISC) functions in DNA repair and breast cancer suppression, while the BRCC36 isopeptidase complex (BRISC) promotes interferon dependent responses by deubiquitinating and stabilizing the type I interferon receptor, IFNAR1."
26344097
BRCC3 affects H2AX
1 | 1
BRCC3 deubiquitinates H2AX. 2 / 2
1 | 1
reach
"BRCC36 de-ubiquitinates H2A/H2AX and RAP80."
31769469
ubibrowser
"BRCA1/2-containing complex36 (BRCC36) is one of the DUBs which localizes at the site of DSBs as a part of the RAP80 complex and deubiquitinates RNF8-dependent γHA2X ubiquitination"
28778421
BRCC3 leads to the deubiquitination of lipopolysaccharide. 1 / 1
| 1
reach
"Recently, BRCC3 in the cytosol has been reported to promote the inflammasome activation by deubiquitinating NLRP3 in LPS primed macrophages [XREF_BIBR]."
25337721
BRCC3 affects USP7
| 1
BRCC3 deubiquitinates USP7. 1 / 1
| 1
reach
"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
28492230
BRCC3 affects UIMC1
| 1
BRCC3 deubiquitinates UIMC1. 1 / 1
| 1
reach
"BRCC36 de-ubiquitinates H2A/H2AX and RAP80."
31769469
BRCC3 affects UBE2N
| 1
BRCC3 deubiquitinates UBE2N. 1 / 1
| 1
reach
"This suggests that BRCC36 normally deubiquitylates the substrate of RNF8 and UBC13 at DSBs."
20029420
BRCC3 affects TNKS
1 |
BRCC3 deubiquitinates TNKS. 1 / 1
1 |
ubibrowser
"Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution"
27993934
BRCC3 affects SYK
| 1
BRCC3 leads to the deubiquitination of SYK. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 affects STAMBPL1
| 1
BRCC3 deubiquitinates STAMBPL1. 1 / 1
| 1
reach
"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
28492230
BRCC3 affects SMAD3
| 1
BRCC3 leads to the deubiquitination of SMAD3. 1 / 1
| 1
reach
"BRCC36 may inhibit the activation of the TGF-beta1 signaling pathway by regulating the ubiquitination of smad3."
30834083
BRCC3 affects SGCG
| 1
BRCC3 deubiquitinates SGCG. 1 / 1
| 1
reach
"Dr. Greenberg group from University of Pennsylvania showed that BRCC36 containing deubiquitinating complex BRISC which is also a sister protein complex of nuclear RAP80-BRCA1 complex, deubiquitinates type I interferon receptor (IFNAR1), resulting in its delayed lysosomal dependent degradation."
27211605
BRCC3 affects RNF8
| 1
BRCC3 deubiquitinates RNF8. 1 / 1
| 1
reach
"This suggests that BRCC36 normally deubiquitylates the substrate of RNF8 and UBC13 at DSBs."
20029420
BRCC3 affects PYCARD
| 1
BRCC3 leads to the deubiquitination of PYCARD. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 affects NUMA1
1 |
BRCC3 deubiquitinates NUMA1. 1 / 1
1 |
ubibrowser
"importantly, BRISC promotes the assembly of functional bipolar spindle by deubiquitinating the essential spindle assembly factor nuclear mitotic apparatus (NuMA)."
26195665
BRCC3 affects NOD
| 1
BRCC3 leads to the deubiquitination of NOD. 1 / 1
| 1
reach
"BRCC3 have been shown to promote the inflammasome activation by deubiquitinating NOD like receptor containing pyrin domain 3 (NLRP3)."
31787240
BRCC3 affects JNK
| 1
BRCC3 leads to the deubiquitination of JNK. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 affects JAK2
1 |
BRCC3 deubiquitinates JAK2. 1 / 1
1 |
ubibrowser
"We show here that a LNK-associated lysine-63 (K63)-deubiquitinating enzyme complex, Brcc36 isopeptidase complex (BRISC), attenuates HSC expansion through control of JAK2 signaling."
30755420
BRCC3 affects IFNAR1
| 1
BRCC3 deubiquitinates IFNAR1. 1 / 1
| 1
reach
"Dr. Greenberg group from University of Pennsylvania showed that BRCC36 containing deubiquitinating complex BRISC which is also a sister protein complex of nuclear RAP80-BRCA1 complex, deubiquitinates type I interferon receptor (IFNAR1), resulting in its delayed lysosomal dependent degradation."
27211605
BRCC3 affects Histone
| 1
BRCC3 deubiquitinates Histone. 1 / 1
| 1
reach
"There are many examples of HDACs being recruited to sites of DNA repair (as discussed above), and the BRCA-1A complex actually contains a DUB, Brcc36, that can deubiquitinate histones at least in vitro."
22249206
BRCC3 affects H2AC17
1 |
BRCC3 deubiquitinates H2AC17. 1 / 1
1 |
BRCC3 affects H2AC11
1 |
BRCC3 deubiquitinates H2AC11. 1 / 1
1 |
signor
"Brcc36 regulates the abundance of lys(63)-linked ubiquitin chains at chromatin and that one of its substrates is diubiquitinated histone h2a"
20656690
BRCC3 affects FANCG
1 |
BRCC3 deubiquitinates FANCG. 1 / 1
1 |
ubibrowser
"?we demonstrated that K63Ub-modified FANCG was deubiquitinated by BRCC36 complex in vitro and in vivo"
25132264
BRCC3 affects COPS5
| 1
BRCC3 deubiquitinates COPS5. 1 / 1
| 1
reach
"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
28492230