IndraLab

Statements

YOD1 affects TRAF6
5 | 22 32
YOD1 binds TRAF6.
5 | 15 32
TRAF6 binds YOD1. 10 / 51
5 | 15 22
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"Therefore, we investigated whether YOD1 and p62 are binding simultaneously to TRAF6 and potentially forming a tripartite complex or if binding of the two MATH domain interactors is mutually exclusive and possibly even competitive."
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"To increase the physiological relevance, we show endogenous interaction of TRAF6 and YOD1 in different cell lines and also primary human umbilical vein endothelial cells (HUVEC) ( xref )."
28244869
sparser
"Co-IP revealed binding of reconstituted YOD1 to TRAF6 in unstimulated cells and the interaction was reduced after IL-1β stimulation ( xref and xref )."
28244869
sparser
"The authors show that YOD1 interacts with the C-terminal MATH domain of TRAF6, and inhibits TRAF6 binding with p62/Sequestosome-1."
28244869
biogrid
No evidence text available
28244869
sparser
"Indeed, co-IP experiments using MYC-TRAF6 together with Crimson-p62 and GFP-YOD1 revealed that YOD1 was able to inhibit the association of TRAF6 and p62, while p62 did not alter the binding of YOD1 to TRAF6 ( xref )."
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"We show that YOD1 binds to TRAF6 in unstimulated cells and that binding is decreased after IL-1 stimulation."
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"To assess the selectivity of YOD1 and TRAF6 interaction, we compared association of YOD1 to TRAF2 and TRAF6 in HEK293 cells (XREF_FIG)."
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"Co-immunoprecipitations (IP) using anti-HA or anti-FLAG antibodies confirmed the interaction of TRAF6 and YOD1 (XREF_FIG)."
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"YOD1 and TRAF6 binding is apparently independent of p97, suggesting that YOD1 affects NF-kappaB signaling in response to IL-1 independent of this multifunctional AAA-ATPase."
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SQSTM1 binds TRAF6 and YOD1. 3 / 3
| 3
sparser
"Also, we quantified the amount of p62 and YOD1 bound to TRAF6 after double transfection (control, set to 1) and triple transfection (TRAF6, p62 and YOD1) in three independent experiments ( xref )."
28244869
sparser
"Therefore, we investigated whether YOD1 and p62 are binding simultaneously to TRAF6 and potentially forming a tripartite complex or if binding of the two MATH domain interactors is mutually exclusive and possibly even competitive."
28244869
sparser
"By directly comparing the binding of YOD1 and p62 to TRAF6 in HEK293 cells we could confirm that both proteins are associating with the C-terminal MATH domain ( xref )."
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IL1 binds TRAF6 and YOD1. 2 / 2
| 2
sparser
"Indeed, it seemed likely that in this overexpression scenario there was slightly augmented association of TRAF6 and YOD1 WT after short IL-1 stimulation."
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sparser
"In fact, IL-1-induced TRAF6 ubiquitination correlates with a decreased binding of YOD1 to TRAF6 after IL-1 stimulation (see xref and xref ), and we asked, whether reduced binding is also visible at the level of endogenous proteins in HeLa cells and primary HUVEC cells ( xref )."
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TRAF binds TRAF6, BLNK, and YOD1. 1 / 1
| 1
sparser
"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
31797949
TRAF6 binds VCP and YOD1. 1 / 1
| 1
sparser
"Despite some weak interaction with cIAP2 and SHARPIN, within this panel YOD1 was quite selectively binding to p97 and TRAF6."
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TRAF6 binds YOD1 and Ubx. 1 / 1
| 1
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"However, neither exchange of the conserved glutamic acid to alanine (YOD1 E96A) nor even more profound mutations of the putative TRAF6 binding motif abolished YOD1 association ( xref and xref ), indicating that binding of TRAF6 MATH to YOD1 UBX domain is not mediated through a typical TIM."
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TRAF2 binds TRAF6 and YOD1. 1 / 1
| 1
sparser
"To assess the selectivity of YOD1/TRAF6 interaction, we compared association of YOD1 to TRAF2 and TRAF6 in HEK293 cells ( xref )."
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TRAF6 binds BLNK, YOD1, and TraF. 1 / 1
| 1
sparser
"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
28244869
YOD1 inhibits TRAF6.
| 4
YOD1 inhibits TRAF6. 4 / 6
| 4
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"Indeed, co-IP experiments using MYC-TRAF6 together with Crimson-p62 and GFP-YOD1 revealed that YOD1 was able to inhibit the association of TRAF6 and p62, while p62 did not alter the binding of YOD1 to TRAF6 (XREF_FIG)."
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"YOD1 antagonizes ubiquitin ligase TRAF6 and p62 dependent interleukin-1 signaling to NF-kappaB."
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"We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non catalytic mechanism."
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"Hence, our data define that YOD1 antagonizes TRAF6 and p62 dependent IL-1 signaling to NF-kappaB."
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YOD1 deubiquitinates TRAF6.
| 2
YOD1 leads to the deubiquitination of TRAF6. 1 / 1
| 1
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"Another DUB, YOD1 (also called Otud2), inhibits TRAF6 ubiquitination and signaling function via a non-catalytic mechanism that involves binding to the C-terminal TRAF domain of TRAF6 and, thereby, preventing TRAF6 interaction with an activating adaptor protein, p62 (also called Sequestosome-1) (67)."
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YOD1-C160S leads to the deubiquitination of TRAF6. 1 / 1
| 1
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"Also, catalytically inactive YOD1 C160S impaired the boost of TRAF6 auto-ubiquitination by p62, even though the inhibition was not quite as severe as with YOD1 WT."
28244869
YOD1 ubiquitinates TRAF6.
| 1
YOD1 leads to the ubiquitination of TRAF6. 1 / 1
| 1
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"Clearly, YOD1 deficiency alone is not sufficient to induce TRAF6 ubiquitination or IKK and NF-kappaB signaling in the absence of any stimulation."
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YOD1 affects VCP
7 1 | 15 15
YOD1 binds VCP.
7 | 12 15
VCP binds YOD1. 10 / 29
7 | 10 12
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"We show that a catalytically inactive deubiquitinating enzyme and p97 cofactor YOD1 enhances the accumulation of K11- and K48 linked polyubiquitin in the cytoplasm, at the ER membrane, and bound to p97."
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"In aggregate, YOD1 interacts directly with p97 and is a novel constituent of the ER dislocation machinery, thereby placing it in a perfect position to process ubiquitinated dislocation substrates in association with p97."
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biogrid
No evidence text available
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sparser
"YOD1, the mammalian homolog of Otu1, also interacts with p97 through its UBX domain [ xref ]."
28159894
sparser
"In addition, p97 binds to a deubiquitinating enzyme YOD1, presumably so that polyubiquitin chains will not interfere with insertion into the proteasome ( xref )."
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"In addition, whereas both H. sapiens YOD1 and OTUD2 and S. cerevisiae Otu1 interact with p97 and Cdc48 through an N-terminal UBL or UBX domain, the A. thaliana OTU2 has a relatively shorter N-terminus and does not interact with CDC48."
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"The UBX-like domain of OTUD2 binds AAA+ ATPase p97, an important Ub-dependent regulator of protein homeostasis (Ernst et al., 2009)."
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"In addition, p97 binds to a deubiquitinating enzyme YOD1, presumably so that polyubiquitin chains will not interfere with insertion into the proteasome."
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"In addition, we confirmed binding of recombinant YOD1 to p97 by GST-PD ( xref )."
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No evidence text available
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VCP binds YOD1 and UBX domain. 2 / 2
| 2
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"YOD1, the mammalian homolog of Otu1, also interacts with p97 through its UBX domain [XREF_BIBR]."
28159894
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"YOD1 interacts with p97 via its UBX domain."
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TRAF6 binds VCP and YOD1. 1 / 1
| 1
sparser
"Despite some weak interaction with cIAP2 and SHARPIN, within this panel YOD1 was quite selectively binding to p97 and TRAF6."
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VCP binds NPLOC4, YOD1, and Ufd1. 1 / 1
| 1
sparser
"In a screen for potential functional partners of YOD1, Ernst et al. discovered an interaction between YOD1 and the p97-Ufd1-Npl4 complex, linking this DUB to the ERQC pathway [ xref ]."
22812527
VCP binds YOD1 and Ubx. 1 / 1
| 1
sparser
"The DUB YOD1, which binds to p97 via its UBX (ubiquitin regulatory X) domain, is also associated with ERAD [ xref ]."
28819009
YOD1 deubiquitinates VCP.
1 | 2
YOD1 deubiquitinates VCP. 3 / 3
1 | 2
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"P97 QQ associated polyubiquitinated proteins can be deubiquitinated in vitro by purified YOD1 (XREF_SUPPLEMENTARY)."
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ubibrowser
"The activity of the p97-associated deubiquitinylase YOD1 is also required for substrate disposal."
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"Ataxin-3 and YOD1 promote the deubiquitination of p97 associated ERAD substrates, and facilitate delivery to the proteasome [21-24]."
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YOD1 inhibits VCP.
| 1
YOD1-C160S inhibits VCP. 1 / 1
| 1
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"Having established that catalytically inactive YOD1 (C160S) inhibits the p97 dependent clearance of K11 and K48 ubiquitinated proteins (XREF_FIG), we next studied the effects of C160S over-expression on CD3delta."
24417208
VCP affects YOD1
7 | 15 15
VCP binds YOD1.
7 | 12 15
VCP binds YOD1. 10 / 29
7 | 10 12
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"We show that a catalytically inactive deubiquitinating enzyme and p97 cofactor YOD1 enhances the accumulation of K11- and K48 linked polyubiquitin in the cytoplasm, at the ER membrane, and bound to p97."
24417208
reach
"In aggregate, YOD1 interacts directly with p97 and is a novel constituent of the ER dislocation machinery, thereby placing it in a perfect position to process ubiquitinated dislocation substrates in association with p97."
19818707
biogrid
No evidence text available
19818707
sparser
"YOD1, the mammalian homolog of Otu1, also interacts with p97 through its UBX domain [ xref ]."
28159894
sparser
"In addition, p97 binds to a deubiquitinating enzyme YOD1, presumably so that polyubiquitin chains will not interfere with insertion into the proteasome ( xref )."
25071743
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"In addition, whereas both H. sapiens YOD1 and OTUD2 and S. cerevisiae Otu1 interact with p97 and Cdc48 through an N-terminal UBL or UBX domain, the A. thaliana OTU2 has a relatively shorter N-terminus and does not interact with CDC48."
24659992
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"The UBX-like domain of OTUD2 binds AAA+ ATPase p97, an important Ub-dependent regulator of protein homeostasis (Ernst et al., 2009)."
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"In addition, p97 binds to a deubiquitinating enzyme YOD1, presumably so that polyubiquitin chains will not interfere with insertion into the proteasome."
25071743
sparser
"In addition, we confirmed binding of recombinant YOD1 to p97 by GST-PD ( xref )."
28244869
biogrid
No evidence text available
19818707
VCP binds YOD1 and UBX domain. 2 / 2
| 2
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"YOD1, the mammalian homolog of Otu1, also interacts with p97 through its UBX domain [XREF_BIBR]."
28159894
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"YOD1 interacts with p97 via its UBX domain."
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TRAF6 binds VCP and YOD1. 1 / 1
| 1
sparser
"Despite some weak interaction with cIAP2 and SHARPIN, within this panel YOD1 was quite selectively binding to p97 and TRAF6."
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VCP binds NPLOC4, YOD1, and Ufd1. 1 / 1
| 1
sparser
"In a screen for potential functional partners of YOD1, Ernst et al. discovered an interaction between YOD1 and the p97-Ufd1-Npl4 complex, linking this DUB to the ERQC pathway [ xref ]."
22812527
VCP binds YOD1 and Ubx. 1 / 1
| 1
sparser
"The DUB YOD1, which binds to p97 via its UBX (ubiquitin regulatory X) domain, is also associated with ERAD [ xref ]."
28819009
VCP activates YOD1.
| 3
VCP activates YOD1. 2 / 2
| 2
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"VCP and p97 recruitment to lysosome membranes and functioning are mediated by its cofactors and adaptors YOD1, UBXD1, and PLAA."
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"VCP and p97 recruitment to lysosome membranes and functioning are mediated by its cofactors and adaptors YOD1, UBXD1, and PLAA."
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VCP bound to GEMIN4 activates YOD1. 1 / 1
| 1
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"VCP and p97 recruitment to lysosome membranes and functioning are mediated by its cofactors and adaptors YOD1, UBXD1, and PLAA."
32792938
YOD1 affects Circulin-C
| 22
YOD1 binds Circulin-C. 10 / 22
| 22
sparser
"The results of pairwise comparison showed a statistically significant difference for circ-YOD1 ( P YOD1-21  < 0.01; P YOD1-296  < 0.05, Fig.  xref )."
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"Our investigation of the triple regulatory networks of circRNA-miRNA-mRNA in CAD revealed circ-YOD1 as a potential biomarker for CAD."
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"Two of these miRNAs were related to CAD xref , xref and can be regulated by circ-YOD1."
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"The expression levels of BCL6 , FBXL18 , MMP9 and FCGR3B were significantly upregulated in the overexpression circ-YOD1 group compared with the negative control."
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"Then, the expression levels of miR-21-3p and miR-296-3p were downregulated significantly in the overexpression circ-YOD1 group compared to the negative control."
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"Therefore, we hypothesized that circ-YOD1 could play a negative regulatory role on miR-21-3p/miR-296-3p expression in CAD."
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"The head-to-tail splicing in the RT-qPCR product of circ-YOD1 was confirmed by Sanger sequencing and is shown in Fig.  xref ."
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"Miao et al. established a triple regulatory network of circRNA-miRNA-mRNA and found circ-YOD1 could be a good marker to predict the onset of CAD [ xref ]."
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"Thus, Circ-YOD1 may regulate parental gene YOD1 expression that leads to CAD."
31797949
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"For example, circ-YOD1 was considered as a biomarker for coronary artery disease [ xref ], and circDLPAG4 was identified as a potential therapeutic target for myocardial ischemia [ xref ]."
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YOD1 affects SYVN1
1 | 11 6
YOD1 binds SYVN1.
1 | 7 6
SYVN1 binds YOD1. 10 / 14
1 | 6 6
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"Whether the YOD1-Hrd1 interaction reflects a direct interaction or an interaction mediated by Hrd1 adaptors is unknown."
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"When FLAG-WT and C160S YOD1 were precipitated from cells under a native condition and the precipitated material probed with antibodies against these membrane proteins, endogenous Hrd1 consistently bound to C160S YOD1 with higher affinity than WT YOD1 ( xref , first panel, compare lane 6 with lane 5; quantified in graph on right)."
24068323
biogrid
No evidence text available
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"WT Hrd1-Myc coprecipitated with FLAG-WT YOD1 only when FLAG-WT YOD1was expressed in cells (XREF_FIG, top and second panels, compare lane 2 with lane 1), indicating that Hrd1 binds to YOD1."
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"This finding indicates that gp78 does not engage YOD1, and demonstrates specificity of the YOD1-Hrd1 interaction."
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"Both WT Hrd1-Myc and cyt Hrd1-Myc but not TM1-6 Hrd1-Myc coprecipitated with FLAG-WT YOD1 ( xref , top three panels, compare lanes 1 and 2 with lane 3), demonstrating that Hrd1’s cytosolic domain interacts with YOD1."
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"Our coimmunoprecipitation experiments revealed that YOD1 binds to Hrd1 via Hrd1 's cytosolic domain."
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"WT Hrd1-Myc coprecipitated with FLAG-WT YOD1 only when FLAG-WT YOD1was expressed in cells ( xref , top and second panels, compare lane 2 with lane 1), indicating that Hrd1 binds to YOD1."
24068323
sparser
"Our coimmunoprecipitation experiments revealed that YOD1 binds to Hrd1 via Hrd1’s cytosolic domain."
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"YOD1 can bind to HRD1, and HRD1 as an ER associated E3 is crucial in the process of reverse transport."
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SYVN1 binds YOD1-C160S. 1 / 1
| 1
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"When FLAG-WT and C160S YOD1 were precipitated from cells under a native condition and the precipitated material probed with antibodies against these membrane proteins, endogenous Hrd1 consistently bound to C160S YOD1 with higher affinity than WT YOD1 (XREF_FIG, first panel, compare lane 6 with lane 5; quantified in graph on right)."
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YOD1 inhibits SYVN1.
| 2
YOD1 inhibits SYVN1. 2 / 2
| 2
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"Despite not affecting Hrd1 's steady-state level, YOD1 knockdown enhanced Hrd1 cross-links (XREF_FIG, compare lane 2 with lane 1), suggesting that YOD1 's absence leads to either preferential Hrd1 oligomerization or recruitment of cellular factors to Hrd1."
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"Supporting this idea, we found that YOD1 knockdown increases Hrd1 cross-links."
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YOD1 deubiquitinates SYVN1.
| 2
YOD1 deubiquitinates SYVN1. 2 / 2
| 2
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"In both of these scenarios, YOD1 would deubiquitinate Hrd1."
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"If the cross-links represent Hrd1 oligomers, it is tempting to speculate that ubiquitination of Hrd1 favors its oligomerization; deubiquitination of Hrd1 by YOD1 would therefore prevent Hrd1 oligomerization."
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YOD1 activates cell population proliferation. 10 / 12
| 12
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"Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-"
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"The CCK-8 assay showed that knockdown of YOD1 by siRNA inhibited the HOK cells proliferation."
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"Using a transgenic mouse model, we showed that the inducible expression of YOD1 enhances the proliferation of hepatocytes and leads to hepatomegaly in a YAP and TAZ-activity-dependent manner."
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"We provide evidence for the first time that YOD1 contributes to changing the abilities of cell proliferation and migration regulated by TGF-β3 signaling pathway, which may be involved in the pathogenesis of NSCL/P.We explored the effects of YOD1 siRNA on the proliferation and migration of HOK cells."
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"In the present study, we have shown that knockdown of YOD1 by siRNA inhibited proliferation and migration of HOK cells in vitro."
30345304
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"Inhibition of Cell Proliferation by YOD1 siRNA."
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"Using a transgenic mouse model, we confirmed that the Dox inducible expression of YOD1 in the liver enhanced the proliferation of hepatocytes, and led to hepatomegaly in a YAP and TAZ-activity-dependent manner."
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"However, a recent study showed that downregulation of YOD1 may promote cell proliferation in cervical cancer cells [28]."
30345304
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"We have shown that knockdown of YOD1 by RNAi inhibits the proliferation and migration of human oral keratinocytes (HOK) cells."
30345304
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"Using a transgenic mouse model, we demonstrate that the inducible expression of YOD1 enhances the proliferation of hepatocytes and leads to hepatomegaly in a YAP and TAZ-activity-dependent manner."
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YOD1 inhibits cell population proliferation. 5 / 5
| 1 4
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"Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-beta3 Signaling Pathway."
30345304
eidos
"However , a recent study showed that downregulation of YOD1 may promote cell proliferation in cervical cancer cells [ 28 ] ."
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"Therefore, our results suggest that the repression of TGF-β3-mediated transcriptional activity mediated by YOD1 RNAi may inhibit cell proliferation and migration to induce NSCL/P.In conclusion, we have shown that the downregulation of YOD1 using RNAi inhibits proliferation and migration of HOK cells, which involve inhibiting the TGF-β3 signaling pathway."
30345304
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"Moreover, overexpression of YOD1 abrogated miR-373-induced proliferation of cervical cancer cells."
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"YOD1 RNAi may inhibit cell proliferation and migration associated with the pathogenesis of NSCL/P through TGF-beta3 signaling."
30345304
SYVN1 affects YOD1
1 | 7 6
SYVN1 binds YOD1. 10 / 14
1 | 6 6
sparser
"Whether the YOD1-Hrd1 interaction reflects a direct interaction or an interaction mediated by Hrd1 adaptors is unknown."
24068323
sparser
"When FLAG-WT and C160S YOD1 were precipitated from cells under a native condition and the precipitated material probed with antibodies against these membrane proteins, endogenous Hrd1 consistently bound to C160S YOD1 with higher affinity than WT YOD1 ( xref , first panel, compare lane 6 with lane 5; quantified in graph on right)."
24068323
biogrid
No evidence text available
24068323
reach
"WT Hrd1-Myc coprecipitated with FLAG-WT YOD1 only when FLAG-WT YOD1was expressed in cells (XREF_FIG, top and second panels, compare lane 2 with lane 1), indicating that Hrd1 binds to YOD1."
24068323
sparser
"This finding indicates that gp78 does not engage YOD1, and demonstrates specificity of the YOD1-Hrd1 interaction."
24068323
sparser
"Both WT Hrd1-Myc and cyt Hrd1-Myc but not TM1-6 Hrd1-Myc coprecipitated with FLAG-WT YOD1 ( xref , top three panels, compare lanes 1 and 2 with lane 3), demonstrating that Hrd1’s cytosolic domain interacts with YOD1."
24068323
reach
"Our coimmunoprecipitation experiments revealed that YOD1 binds to Hrd1 via Hrd1 's cytosolic domain."
24068323
sparser
"WT Hrd1-Myc coprecipitated with FLAG-WT YOD1 only when FLAG-WT YOD1was expressed in cells ( xref , top and second panels, compare lane 2 with lane 1), indicating that Hrd1 binds to YOD1."
24068323
sparser
"Our coimmunoprecipitation experiments revealed that YOD1 binds to Hrd1 via Hrd1’s cytosolic domain."
24068323
reach
"YOD1 can bind to HRD1, and HRD1 as an ER associated E3 is crucial in the process of reverse transport."
33546413
SYVN1 binds YOD1-C160S. 1 / 1
| 1
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"When FLAG-WT and C160S YOD1 were precipitated from cells under a native condition and the precipitated material probed with antibodies against these membrane proteins, endogenous Hrd1 consistently bound to C160S YOD1 with higher affinity than WT YOD1 (XREF_FIG, first panel, compare lane 6 with lane 5; quantified in graph on right)."
24068323
YOD1 affects NFkappaB
| 6
YOD1 activates NFkappaB.
| 4
YOD1 activates NFkappaB. 4 / 7
| 4
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"Potentially, YOD1 could also function as a p97 co-factor for IkappaBalpha degradation to support canonical NF-kappaB signaling, but it is unclear why this would affect signaling in response to some inducers (e.g. CD40) while others are unaffected (e.g. IL-1 and TNF)."
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"However, why and how YOD1 promotes canonical NF-kappaB signaling and activation in the context of p62 independent CD40 or RANK stimulation is currently unclear and we can only speculate."
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"Whereas knock-down of TRAF6 or p62 severely impaired IL-1beta triggered NF-kappaB activation as evident by EMSA, depletion of YOD1 enhanced NF-kappaB activation (XREF_FIG)."
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"YOD1 is released from TRAF6 upon IL-1 stimulation and YOD1 depletion enhances canonical NF-kappaB activation."
28244869
YOD1 inhibits NFkappaB.
| 1
YOD1 inhibits NFkappaB. 1 / 2
| 1
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"Further, IL-1 triggered IKK and NF-kappaB signaling and induction of target genes is decreased by YOD1 overexpression and augmented after YOD1 depletion."
28244869
YOD1 ubiquitinates NFkappaB.
| 1
YOD1 leads to the ubiquitination of NFkappaB. 1 / 1
| 1
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"Clearly, YOD1 deficiency alone is not sufficient to induce TRAF6 ubiquitination or IKK and NF-kappaB signaling in the absence of any stimulation."
28244869
YOD1 affects SQSTM1
| 4 3
YOD1 binds SQSTM1.
| 1 3
SQSTM1 binds TRAF6 and YOD1. 3 / 3
| 3
sparser
"Also, we quantified the amount of p62 and YOD1 bound to TRAF6 after double transfection (control, set to 1) and triple transfection (TRAF6, p62 and YOD1) in three independent experiments ( xref )."
28244869
sparser
"Therefore, we investigated whether YOD1 and p62 are binding simultaneously to TRAF6 and potentially forming a tripartite complex or if binding of the two MATH domain interactors is mutually exclusive and possibly even competitive."
28244869
sparser
"By directly comparing the binding of YOD1 and p62 to TRAF6 in HEK293 cells we could confirm that both proteins are associating with the C-terminal MATH domain ( xref )."
28244869
SQSTM1 binds YOD1. 1 / 1
| 1
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"By directly comparing the binding of YOD1 and p62 to TRAF6 in HEK293 cells we could confirm that both proteins are associating with the C-terminal MATH domain (XREF_FIG)."
28244869
YOD1 inhibits SQSTM1.
| 3
YOD1 inhibits SQSTM1. 3 / 3
| 3
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"Hence, our data define that YOD1 antagonizes TRAF6 and p62 dependent IL-1 signaling to NF-kappaB."
28244869
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"YOD1 antagonizes ubiquitin ligase TRAF6 and p62 dependent interleukin-1 signaling to NF-kappaB."
33343629
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"Indeed, co-IP experiments using MYC-TRAF6 together with Crimson-p62 and GFP-YOD1 revealed that YOD1 was able to inhibit the association of TRAF6 and p62, while p62 did not alter the binding of YOD1 to TRAF6 (XREF_FIG)."
28244869
YOD1 affects DES
1 | 5
YOD1 deubiquitinates DES.
1 | 1
YOD1 deubiquitinates DES. 2 / 2
1 | 1
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"YOD1, a DUB from OTU family, deubiquitinates desmin."
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ubibrowser
"YOD1, a DUB from OTU family, deubiquitinates desmin."
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YOD1 activates DES.
| 2
YOD1 activates DES. 2 / 2
| 2
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"Suppression of YOD1 by miR-21 promoted desmin degradation and desmosome disorganization."
24722419
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"Interestingly, both miR-21 and YOD1 siRNAs induced the re-distribution of desmin, resulting in increased co-localization of desmin and proteasomes."
24722419
YOD1 ubiquitinates DES.
| 1
YOD1 leads to the ubiquitination of DES. 1 / 1
| 1
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"As shown in XREF_FIG, single mutation at K108 or K406 (K108R or K406R) attenuated the ubiquitination and downregulation of desmin induced by miR-21, YOD1 siRNA or CVB3 infection compared with the wt desmin."
24722419
YOD1 inhibits DES.
| 1
YOD1 inhibits DES. 1 / 1
| 1
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"Suppression of YOD1 Induces Desmin Degradation and Desmosome Disruption."
24722419
MIR21 affects YOD1
| 6
MIR21 inhibits YOD1.
| 4
MIR21 inhibits YOD1. 4 / 4
| 4
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"Suppression of YOD1 by miR-21 promoted desmin degradation and desmosome disorganization."
24722419
reach
"To further confirm that YOD1 inhibition and desmin downregulation is mediated by miR-21, we transfected cells with miR-362 as an additional non specific control, which showed no effect on the expression levels of gamma-catenin, desmin, YOD1 and ubiquitinated desmin."
24722419
reach
"Similar reduction of YOD1 by miR-21 was observed in CVB3 infected samples (XREF_FIG)."
24722419
reach
"zTo confirm that the YOD1 suppression by miR-21 leads to the degradation of desmin during CVB3 infection, we utilized small interference RNA (siRNA) to knockdown endogenous YOD1, which mimicked the effect of miR-21 on YOD1 expression."
24722419
MIR21 activates YOD1.
| 2
MIR21 activates YOD1. 2 / 2
| 2
reach
"Furthermore, infection by the enterovirus coxsackievirus B3 (CVB3) leads to cardiac failure by inducing miR-21 expression, which targets the deubiquitinating enzyme YOD1."
25795143
reach
"Exosomes derived from hypoxic tumor cells were rich in miR-21, which induced NFs activation towards CAFs by targeting YOD1."
37230199
YOD1 affects UBC
5 |
UBC binds YOD1. 5 / 5
5 |
biogrid
No evidence text available
19818707
biogrid
No evidence text available
23827681
biogrid
No evidence text available
23827681
biogrid
No evidence text available
27066941
biogrid
No evidence text available
19818707
YOD1 affects TRAF2
| 1 4
TRAF2 binds YOD1. 4 / 4
| 1 3
sparser
"This study shows that the deubiquitinating enzyme YOD1 can bind to the MATH domain of TRAF2 and that this binding is competitive with that of the binding of p62/Sequestosome-1 to TRAF6."
28244869
reach
"Since we did not observe an interaction between YOD1 and TRAF2, which is involved in TNFR signaling, we directly compared the effect of YOD1 knock-down on NF-kappaB activation in response to either IL-1beta or TNFalpha stimulation (XREF_FIG)."
28244869
sparser
"Since we did not observe an interaction between YOD1 and TRAF2, which is involved in TNFR signaling ( xref ; xref ), we directly compared the effect of YOD1 knock-down on NF-κB activation in response to either IL-1β or TNFα stimulation ( xref )."
28244869
sparser
"We did not detect YOD1-TRAF2 binding, indicating a selectivity of YOD1 for association with TRAF6."
28244869
TRAF2 binds TRAF6 and YOD1. 1 / 1
| 1
sparser
"To assess the selectivity of YOD1/TRAF6 interaction, we compared association of YOD1 to TRAF2 and TRAF6 in HEK293 cells ( xref )."
28244869
YOD1 affects TGFB
| 5
YOD1 increases the amount of TGFB.
| 2
YOD1 increases the amount of TGFB. 2 / 2
| 2
reach
"The results of our study have shown that silencing of YOD1 by RNAi in HOK cells inhibits protein level of phosphor-Smad2/3 which may be associated with inhibition of TGF-β3 expression by YOD1 siRNA.Our data suggest that YOD1 siRNA will reduce the expression levels of TGF-β3 and phospho-Smad2/3."
30345304
reach
"Furthermore, we have found that YOD1 siRNA decreases the mRNA levels of TGF-β3 and protein levels of phosphor-Smad2/3."
30345304
YOD1 inhibits TGFB.
| 1
YOD1 inhibits TGFB. 1 / 1
| 1
reach
"YOD1 RNAi inhibits TGF-β3 signaling pathway to suppress cell proliferation and migration contributing to NSCL/P."
30345304
YOD1 deubiquitinates TGFB.
| 1
YOD1 leads to the deubiquitination of TGFB. 1 / 1
| 1
reach
"YOD1 siRNA may enhance the ubiquitylation of TGF-β3 and phospho-Smad2/3 and then result in the downregulation of TGF-β signaling.The mechanism of inhibition of cell proliferation and migration caused by YOD1 siRNA may be associated with TGF-β3 signaling pathway, which is involved in NSCL/P."
30345304
YOD1 activates TGFB.
| 1
YOD1 activates TGFB. 1 / 1
| 1
reach
"Silencing of YOD1 by RNAi has been shown to downregulate TGF-β signaling."
30345304
YOD1 affects IL1
| 1 2
YOD1 inhibits IL1.
| 1
YOD1 inhibits IL1. 1 / 3
| 1
reach
"Hence, our data define that YOD1 antagonizes TRAF6 and p62 dependent IL-1 signaling to NF-kappaB."
28244869
YOD1 binds IL1.
| 2
IL1 binds TRAF6 and YOD1. 2 / 2
| 2
sparser
"Indeed, it seemed likely that in this overexpression scenario there was slightly augmented association of TRAF6 and YOD1 WT after short IL-1 stimulation."
28244869
sparser
"In fact, IL-1-induced TRAF6 ubiquitination correlates with a decreased binding of YOD1 to TRAF6 after IL-1 stimulation (see xref and xref ), and we asked, whether reduced binding is also visible at the level of endogenous proteins in HeLa cells and primary HUVEC cells ( xref )."
28244869
YOD1 affects DERL1
1 | 1 3
FAF2 binds YOD1 and DERL1. 3 / 3
| 3
sparser
"Immunoprecipitation experiments showed that YOD1 also interacts with the ERAD machinery components such as Derlin-1 and UBXD8."
22812527
sparser
"In agreement with a catalytic role of YOD1 in protein dislocation, the catalytically inactive forms of YOD1 retrieved Derlin-1 and UBXD8 more efficiently than the WT counterpart."
19818707
sparser
"Interaction between YOD1 and other components of ERAD such as Derlin-1 and Ubxd8 were also reported."
25013401
YOD1 binds DERL1. 2 / 2
1 | 1
biogrid
No evidence text available
19818707
reach
"Derlin-1 bound to mutant and WT YOD1 with a similar affinity (XREF_FIG, third panel, compare lane 6 with lane 5), whereas gp78, Sel1L, and Derlin-2 (another ERAD membrane component) did not interact with either WT or mutant YOD1 (XREF_FIG, second, fourth, and fifth panels, lanes 5 and 6)."
24068323
YOD1 affects CTA1
| 5
YOD1 inhibits CTA1.
| 2
YOD1 inhibits CTA1. 1 / 1
| 1
reach
"In contrast, the deubiquitinase YOD1 has been reported to negatively regulate CTA1 membrane extraction."
28351922
YOD1-C160S inhibits CTA1. 1 / 1
| 1
reach
"To further dissect YOD1 's role in CTA1 retro translocation, we found that overexpression of the catalytically inactive C160S YOD1 but not WT YOD1 markedly decreased CTA1 arrival to the cytosol."
24068323
YOD1 deubiquitinates CTA1.
| 1
YOD1 leads to the deubiquitination of CTA1. 1 / 1
| 1
reach
"Because YOD1 knockdown did not promote CTA1 ubiquitination, despite increasing total cellular polyubiquitinated proteins, we propose that YOD1 imposes its negative role by deubiquitinating components of the ERAD machinery that normally promote retro translocation when ubiquitinated (XREF_FIG)."
24068323
YOD1 decreases the amount of CTA1.
| 1
YOD1 decreases the amount of CTA1. 1 / 1
| 1
reach
"Using this semipermeabilized system, we found that YOD1 knockdown increased the CTA1 level in the supernatant fraction (XREF_FIG, top panel, compare lanes 2 and 3 with lane 1; quantified in XREF_FIG), suggesting that YOD1 normally exerts a negative function during ER-to-cytosol transport of the toxin."
24068323
YOD1 activates CTA1.
| 1
YOD1 activates CTA1. 1 / 1
| 1
reach
"Studies have shown that YOD1 negatively regulates the reverse transport of CTA1, and the mechanism of action may be the deubiquitination of some ERAD components that promote reverse transport of the protein rather than substrate ubiquitination."
33546413
UBC affects YOD1
5 |
UBC binds YOD1. 5 / 5
5 |
biogrid
No evidence text available
19818707
biogrid
No evidence text available
23827681
biogrid
No evidence text available
23827681
biogrid
No evidence text available
27066941
biogrid
No evidence text available
19818707
TRAF2 affects YOD1
| 1 4
TRAF2 binds YOD1. 4 / 4
| 1 3
sparser
"This study shows that the deubiquitinating enzyme YOD1 can bind to the MATH domain of TRAF2 and that this binding is competitive with that of the binding of p62/Sequestosome-1 to TRAF6."
28244869
reach
"Since we did not observe an interaction between YOD1 and TRAF2, which is involved in TNFR signaling, we directly compared the effect of YOD1 knock-down on NF-kappaB activation in response to either IL-1beta or TNFalpha stimulation (XREF_FIG)."
28244869
sparser
"Since we did not observe an interaction between YOD1 and TRAF2, which is involved in TNFR signaling ( xref ; xref ), we directly compared the effect of YOD1 knock-down on NF-κB activation in response to either IL-1β or TNFα stimulation ( xref )."
28244869
sparser
"We did not detect YOD1-TRAF2 binding, indicating a selectivity of YOD1 for association with TRAF6."
28244869
TRAF2 binds TRAF6 and YOD1. 1 / 1
| 1
sparser
"To assess the selectivity of YOD1/TRAF6 interaction, we compared association of YOD1 to TRAF2 and TRAF6 in HEK293 cells ( xref )."
28244869
DERL1 affects YOD1
1 | 1 3
FAF2 binds YOD1 and DERL1. 3 / 3
| 3
sparser
"Immunoprecipitation experiments showed that YOD1 also interacts with the ERAD machinery components such as Derlin-1 and UBXD8."
22812527
sparser
"In agreement with a catalytic role of YOD1 in protein dislocation, the catalytically inactive forms of YOD1 retrieved Derlin-1 and UBXD8 more efficiently than the WT counterpart."
19818707
sparser
"Interaction between YOD1 and other components of ERAD such as Derlin-1 and Ubxd8 were also reported."
25013401
YOD1 binds DERL1. 2 / 2
1 | 1
biogrid
No evidence text available
19818707
reach
"Derlin-1 bound to mutant and WT YOD1 with a similar affinity (XREF_FIG, third panel, compare lane 6 with lane 5), whereas gp78, Sel1L, and Derlin-2 (another ERAD membrane component) did not interact with either WT or mutant YOD1 (XREF_FIG, second, fourth, and fifth panels, lanes 5 and 6)."
24068323
Hsa-miR-98-5p affects YOD1
4 |
Hsa-miR-98-5p decreases the amount of YOD1. 4 / 4
4 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
19088304
Hsa-miR-1299 affects YOD1
4 |
Hsa-miR-1299 decreases the amount of YOD1. 4 / 4
4 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
YOD1
1 | 2
YOD1 translocates.
| 2
YOD1 translocates to the mitochondrion. 2 / 2
| 2
reach
"YOD1 was recruited to mitochondria to interact with MAVS through its UBX and Znf domains after viral infection."
30952814
reach
"Following a Sendai virus infection, YOD1 was recruited to mitochondria and was shown to interact with MAVS."
33511009
YOD1 binds.
1 |
YOD1 binds YOD1. 1 / 2
1 |
hprd
No evidence text available
7644498
YOD1 affects cell migration
| 1 3
YOD1 activates cell migration. 4 / 4
| 1 3
reach
"YOD1 overexpression enhances cell migration by promoting TGF-beta3 signaling which may play an important role in lip and palate formation."
30145984
reach
"RNA interference and overexpression experiments indicated that YOD1 could enhance cell migration during lip and palate formation through the transforming growth factor (TGF)-beta3 signaling pathway."
33343629
reach
"Inhibition of Cell Migration by YOD1 siRNA."
30345304
eidos
"RNA interference and overexpression experiments indicated that YOD1 could enhance cell migration during lip and palate formation through the transforming growth factor ( TGF ) - beta3 signaling pathway ( Zhou et al ., 2018 ) ."
33343629
YOD1 affects Ubiquitin
| 2 2
YOD1 inhibits Ubiquitin.
| 2
YOD1 inhibits Ubiquitin. 2 / 2
| 2
reach
"YOD1 antagonizes ubiquitin ligase TRAF6 and p62 dependent interleukin-1 signaling to NF-kappaB."
33343629
reach
"In support of this model, over-expression of catalytically inactive YOD1 (referred to as C160S) has been shown to block the ubiquitin dependent degradation of model ERAD substrates [XREF_BIBR]."
24417208
YOD1 binds Ubiquitin.
| 2
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
Ubiquitin binds YOD1. 1 / 1
| 1
sparser
"Several of these residues are solvent exposed in Ub, suggesting that OTUD2 binds to these residues of the proximal Ub."
23827681
YOD1 affects MAVS
| 3 1
YOD1 inhibits MAVS.
| 2
YOD1 inhibits MAVS. 2 / 2
| 2
reach
"The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63 Linked Deubiquitination."
30952814
reach
"Subsequently, YOD1 removes the K63 linked ubiquitin chain and abrogates the aggregation of MAVS, thus inhibiting not only IRF3 and p65 activation, but also IFN-beta production."
33511009
YOD1 binds MAVS.
| 1
YOD1 binds MAVS. 1 / 1
| 1
sparser
"After viral infection, OTUD2 (also known as YOD1) interacts with MAVS through its UBX and Znf domains at the mitochondria, followed by the cleavage the K63-linked ubiquitin chains of MAVS that induced the abrogation of MAVS oligomerization to attenuate the IFN production [ xref ]."
35008917
YOD1 activates MAVS.
| 1
YOD1 activates MAVS. 1 / 1
| 1
reach
"Liu and colleagues reported YOD1 mediated K63 linked deubiquitination could activate an innate antiviral immune response against viral infection, and the aggregation of MAVS."
33343629
YOD1 affects ITCH
1 | 3
YOD1 deubiquitinates ITCH. 4 / 4
1 | 3
reach
"A recent study reported that YOD1 could deubiquitinate ITCH, and enhanced the stability of ITCH, which subsequently reduced the levels of LATS and increased the YAP/TAZ level."
34315490
reach
"Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP and TAZ level."
28502290
reach
"Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP and TAZ level."
28416659
ubibrowser
"Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability"
28416659
YOD1 affects FAF2
1 | 3
FAF2 binds YOD1 and DERL1. 3 / 3
| 3
sparser
"Immunoprecipitation experiments showed that YOD1 also interacts with the ERAD machinery components such as Derlin-1 and UBXD8."
22812527
sparser
"In agreement with a catalytic role of YOD1 in protein dislocation, the catalytically inactive forms of YOD1 retrieved Derlin-1 and UBXD8 more efficiently than the WT counterpart."
19818707
sparser
"Interaction between YOD1 and other components of ERAD such as Derlin-1 and Ubxd8 were also reported."
25013401
FAF2 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19818707
SQSTM1 affects YOD1
| 1 3
SQSTM1 binds TRAF6 and YOD1. 3 / 3
| 3
sparser
"Also, we quantified the amount of p62 and YOD1 bound to TRAF6 after double transfection (control, set to 1) and triple transfection (TRAF6, p62 and YOD1) in three independent experiments ( xref )."
28244869
sparser
"Therefore, we investigated whether YOD1 and p62 are binding simultaneously to TRAF6 and potentially forming a tripartite complex or if binding of the two MATH domain interactors is mutually exclusive and possibly even competitive."
28244869
sparser
"By directly comparing the binding of YOD1 and p62 to TRAF6 in HEK293 cells we could confirm that both proteins are associating with the C-terminal MATH domain ( xref )."
28244869
SQSTM1 binds YOD1. 1 / 1
| 1
reach
"By directly comparing the binding of YOD1 and p62 to TRAF6 in HEK293 cells we could confirm that both proteins are associating with the C-terminal MATH domain (XREF_FIG)."
28244869
FAF2 affects YOD1
1 | 3
FAF2 binds YOD1 and DERL1. 3 / 3
| 3
sparser
"Immunoprecipitation experiments showed that YOD1 also interacts with the ERAD machinery components such as Derlin-1 and UBXD8."
22812527
sparser
"In agreement with a catalytic role of YOD1 in protein dislocation, the catalytically inactive forms of YOD1 retrieved Derlin-1 and UBXD8 more efficiently than the WT counterpart."
19818707
sparser
"Interaction between YOD1 and other components of ERAD such as Derlin-1 and Ubxd8 were also reported."
25013401
FAF2 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19818707
Hsa-miR-93-5p affects YOD1
3 |
Hsa-miR-93-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-888-5p affects YOD1
3 |
Hsa-miR-888-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-8073 affects YOD1
3 |
Hsa-miR-8073 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6839-5p affects YOD1
3 |
Hsa-miR-6839-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6831-5p affects YOD1
3 |
Hsa-miR-6831-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6818-5p affects YOD1
3 |
Hsa-miR-6818-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-661 affects YOD1
3 |
Hsa-miR-661 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-583 affects YOD1
3 |
Hsa-miR-583 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-5706 affects YOD1
3 |
Hsa-miR-5706 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-5582-3p affects YOD1
3 |
Hsa-miR-5582-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-548o-3p affects YOD1
3 |
Hsa-miR-548o-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-516b-5p affects YOD1
3 |
Hsa-miR-516b-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4782-5p affects YOD1
3 |
Hsa-miR-4782-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4772-5p affects YOD1
3 |
Hsa-miR-4772-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4764-5p affects YOD1
3 |
Hsa-miR-4764-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4650-3p affects YOD1
3 |
Hsa-miR-4650-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4500 affects YOD1
3 |
Hsa-miR-4500 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4458 affects YOD1
3 |
Hsa-miR-4458 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4316 affects YOD1
3 |
Hsa-miR-4316 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3927-3p affects YOD1
3 |
Hsa-miR-3927-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-383-5p affects YOD1
3 |
Hsa-miR-383-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-378j affects YOD1
3 |
Hsa-miR-378j decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3658 affects YOD1
3 |
Hsa-miR-3658 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-3653-3p affects YOD1
3 |
Hsa-miR-3653-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3614-3p affects YOD1
3 |
Hsa-miR-3614-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-3116 affects YOD1
3 |
Hsa-miR-3116 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-221-5p affects YOD1
3 |
Hsa-miR-221-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-2115-3p affects YOD1
3 |
Hsa-miR-2115-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-21-5p affects YOD1
3 |
Hsa-miR-21-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
22227207
biopax:mirtarbase
No evidence text available
18591254
Hsa-miR-202-3p affects YOD1
3 |
Hsa-miR-202-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-196b-5p affects YOD1
3 |
Hsa-miR-196b-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-196a-5p affects YOD1
3 |
Hsa-miR-196a-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-1323 affects YOD1
3 |
Hsa-miR-1323 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-1294 affects YOD1
3 |
Hsa-miR-1294 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1254 affects YOD1
3 |
Hsa-miR-1254 decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-1237-3p affects YOD1
3 |
Hsa-miR-1237-3p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-let-7i-5p affects YOD1
3 |
Hsa-let-7i-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-let-7g-5p affects YOD1
3 |
Hsa-let-7g-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-let-7f-5p affects YOD1
3 |
Hsa-let-7f-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-let-7e-5p affects YOD1
3 |
Hsa-let-7e-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-let-7d-5p affects YOD1
3 |
Hsa-let-7d-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-let-7c-5p affects YOD1
3 |
Hsa-let-7c-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-let-7b-5p affects YOD1
3 |
Hsa-let-7b-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-let-7a-5p affects YOD1
3 |
Hsa-let-7a-5p decreases the amount of YOD1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Enzalutamide affects YOD1
| 3
Enzalutamide activates YOD1.
| 2
Enzalutamide activates YOD1. 2 / 2
| 2
reach
"Enzalutamide-resistant related lncRNA NONHSAT210528 appears to promote the proliferation and invasion of C4-2 and C4-2b cells by functioning as a ceRNA and regulating the miR-21-5p/YOD1 signal pathway."
35693714
reach
"Enzalutamide-resistant related lncRNA NONHSAT210528 appears to promote the proliferation and invasion of PCa cells by functioning as a ceRNA and regulating the miR-21-5p/YOD1 signal pathway."
35693714
Enzalutamide increases the amount of YOD1.
| 1
Enzalutamide increases the amount of YOD1. 1 / 1
| 1
reach
"However, there are few reports about the role of lncRNA in disease progression after enzalutamide resistance in PCa.In this study, we found that enzalutamide resistance induced by lncRNA NONHSAT210528 promoted the expression of YOD1 through the mechanism of competitive endogenous RNA (ceRNA) by regulating the expression of miR-21-5p in PCa cells after resistance to enzalutamide."
35693714
Bisphenol A affects YOD1
3 |
Bisphenol A decreases the amount of YOD1.
2 |
Bisphenol A decreases the amount of YOD1. 2 / 2
2 |
ctd
No evidence text available
30816183
ctd
No evidence text available
20678512
Bisphenol A methylates YOD1.
1 |
Bisphenol A methylates YOD1. 1 / 1
1 |
ctd
No evidence text available
30906313
YOD1 affects UBXN6
| 3
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
UBXN6 binds YOD1 and PLAA. 1 / 1
| 1
sparser
"While p97 (Valosin-containing protein) translocates to the lysosome to form a complex with UBXD1, PLAA, and YOD1."
33114389
UBXN6 binds YOD1, ISG15, and PLAA. 1 / 1
| 1
sparser
"In addition, several cofactors of VCP were found to interact with ISG15 such as the VCP-UFD1-NPL4 protein complex as well as PLAA, UBXN6 and YOD1 44 , FAF1, NSFL1C, UBXN1, and RNF115 [45] [46] [47] [48] ."
34599178
YOD1 affects CTNNB1
| 3
YOD1 inhibits CTNNB1. 3 / 3
| 3
reach
"YOD1 inactivated the YAP/beta-catenin pathway."
34282135
reach
"YOD1 inactivated the YAP and beta-catenin pathway."
34282135
reach
"YOD1 inhibited the YAP/beta-catenin pathway."
34282135
YOD1 affects AMFR
1 | 1 1
YOD1 binds AMFR. 3 / 3
1 | 1 1
reach
"Accordingly, we first asked whether YOD1 binds to Hrd1 and gp78, as this DUB was shown to regulate the ERAD process."
24068323
biogrid
No evidence text available
24068323
sparser
"By contrast, we failed to detect any YOD1-gp78 interaction."
24068323
UBXN6 affects YOD1
| 3
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
UBXN6 binds YOD1 and PLAA. 1 / 1
| 1
sparser
"While p97 (Valosin-containing protein) translocates to the lysosome to form a complex with UBXD1, PLAA, and YOD1."
33114389
UBXN6 binds YOD1, ISG15, and PLAA. 1 / 1
| 1
sparser
"In addition, several cofactors of VCP were found to interact with ISG15 such as the VCP-UFD1-NPL4 protein complex as well as PLAA, UBXN6 and YOD1 44 , FAF1, NSFL1C, UBXN1, and RNF115 [45] [46] [47] [48] ."
34599178
TRAF6 affects SQSTM1
| 3
SQSTM1 binds TRAF6 and YOD1. 3 / 3
| 3
sparser
"Also, we quantified the amount of p62 and YOD1 bound to TRAF6 after double transfection (control, set to 1) and triple transfection (TRAF6, p62 and YOD1) in three independent experiments ( xref )."
28244869
sparser
"Therefore, we investigated whether YOD1 and p62 are binding simultaneously to TRAF6 and potentially forming a tripartite complex or if binding of the two MATH domain interactors is mutually exclusive and possibly even competitive."
28244869
sparser
"By directly comparing the binding of YOD1 and p62 to TRAF6 in HEK293 cells we could confirm that both proteins are associating with the C-terminal MATH domain ( xref )."
28244869
PLAA affects YOD1
| 3
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
UBXN6 binds YOD1 and PLAA. 1 / 1
| 1
sparser
"While p97 (Valosin-containing protein) translocates to the lysosome to form a complex with UBXD1, PLAA, and YOD1."
33114389
UBXN6 binds YOD1, ISG15, and PLAA. 1 / 1
| 1
sparser
"In addition, several cofactors of VCP were found to interact with ISG15 such as the VCP-UFD1-NPL4 protein complex as well as PLAA, UBXN6 and YOD1 44 , FAF1, NSFL1C, UBXN1, and RNF115 [45] [46] [47] [48] ."
34599178
YOD1 is modified
1 | 2
YOD1 is methylated.
| 2
YOD1 is methylated. 2 / 2
| 2
sparser
"In the tumor bearing livers, the methylation of Derl3, Herp, and Yod1 was reduced in the tumor portion compared to the normal liver portion whereas the methylation of Creld2 or Wfs was not significantly changed in the tumor portion compared to the liver portion."
24198826
sparser
"We identified methylation in YOD1, UGT8, FNDC3B, and SLIT2 as new epigenetic factors associated with late-life MDD, which are not confounded by cognitive status or a genetic risk for MDD and stronger associated with MDD in male than in female."
32733030
YOD1 is phosphorylated.
1 |
YOD1 is phosphorylated on T150. 1 / 1
1 |
hprd
No evidence text available
20068231
FAF2 affects DERL1
| 3
FAF2 binds YOD1 and DERL1. 3 / 3
| 3
sparser
"Immunoprecipitation experiments showed that YOD1 also interacts with the ERAD machinery components such as Derlin-1 and UBXD8."
22812527
sparser
"In agreement with a catalytic role of YOD1 in protein dislocation, the catalytically inactive forms of YOD1 retrieved Derlin-1 and UBXD8 more efficiently than the WT counterpart."
19818707
sparser
"Interaction between YOD1 and other components of ERAD such as Derlin-1 and Ubxd8 were also reported."
25013401
AMFR affects YOD1
1 | 1 1
YOD1 binds AMFR. 3 / 3
1 | 1 1
reach
"Accordingly, we first asked whether YOD1 binds to Hrd1 and gp78, as this DUB was shown to regulate the ERAD process."
24068323
biogrid
No evidence text available
24068323
sparser
"By contrast, we failed to detect any YOD1-gp78 interaction."
24068323
Valproic acid affects YOD1
2 |
Valproic acid decreases the amount of YOD1. 2 / 2
2 |
ctd
No evidence text available
23179753
ctd
No evidence text available
27188386
Pirinixic acid affects YOD1
2 |
Pirinixic acid decreases the amount of YOD1.
1 |
Pirinixic acid decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid activates YOD1.
1 |
Pirinixic acid activates YOD1. 1 / 1
1 |
ctd
No evidence text available
19710929
MiR-373 affects YOD1
| 2
MiR-373 inhibits YOD1.
| 1
MiR-373 inhibits YOD1. 1 / 1
| 1
reach
"These results demonstrate that miR-373 increases proliferation by directly targeting YOD1, a new potential therapeutic target in cervical cancer."
25747718
MiR-373 activates YOD1.
| 1
MiR-373 activates YOD1. 1 / 1
| 1
reach
"In the present study, it was confirmed that miR-373 directly targets YOD1 by binding its 3 '-UTR."
25747718
MiR-21-5p affects YOD1
| 2
MiR-21-5p decreases the amount of YOD1.
| 1
MiR-21-5p decreases the amount of YOD1. 1 / 1
| 1
reach
"The Western blot showed that miR-21-5p overexpression inhibited the expression of the YOD1 protein, while miR-21-5p knockdown promoted the expression of the YOD1 protein (see Figure 8C)."
35693714
MiR-21-5p activates YOD1.
| 1
MiR-21-5p activates YOD1. 1 / 1
| 1
reach
"MiR-21-5p targeted YOD1."
34282135
Hsa-miR-7161-3p affects YOD1
2 |
Hsa-miR-7161-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-7-5p affects YOD1
2 |
Hsa-miR-7-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6806-3p affects YOD1
2 |
Hsa-miR-6806-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-643 affects YOD1
2 |
Hsa-miR-643 decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6128 affects YOD1
2 |
Hsa-miR-6128 decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6077 affects YOD1
2 |
Hsa-miR-6077 decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6073 affects YOD1
2 |
Hsa-miR-6073 decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-520e affects YOD1
2 |
Hsa-miR-520e decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-520d-3p affects YOD1
2 |
Hsa-miR-520d-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-520c-3p affects YOD1
2 |
Hsa-miR-520c-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-520b affects YOD1
2 |
Hsa-miR-520b decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-520a-3p affects YOD1
2 |
Hsa-miR-520a-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-519d-3p affects YOD1
2 |
Hsa-miR-519d-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-3928-5p affects YOD1
2 |
Hsa-miR-3928-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-373-3p affects YOD1
2 |
Hsa-miR-373-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-372-3p affects YOD1
2 |
Hsa-miR-372-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-3606-5p affects YOD1
2 |
Hsa-miR-3606-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-3156-5p affects YOD1
2 |
Hsa-miR-3156-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3126-3p affects YOD1
2 |
Hsa-miR-3126-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-302e affects YOD1
2 |
Hsa-miR-302e decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-302d-3p affects YOD1
2 |
Hsa-miR-302d-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-302c-3p affects YOD1
2 |
Hsa-miR-302c-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-302b-3p affects YOD1
2 |
Hsa-miR-302b-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-302a-3p affects YOD1
2 |
Hsa-miR-302a-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-20b-5p affects YOD1
2 |
Hsa-miR-20b-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22473208
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-20a-5p affects YOD1
2 |
Hsa-miR-20a-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-17-5p affects YOD1
2 |
Hsa-miR-17-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-144-3p affects YOD1
2 |
Hsa-miR-144-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-142-3p affects YOD1
2 |
Hsa-miR-142-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-1298-3p affects YOD1
2 |
Hsa-miR-1298-3p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-127-5p affects YOD1
2 |
Hsa-miR-127-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-125a-5p affects YOD1
2 |
Hsa-miR-125a-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-106b-5p affects YOD1
2 |
Hsa-miR-106b-5p decreases the amount of YOD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
22473208
Benzo[a]pyrene diol epoxide I increases the amount of YOD1. 2 / 2
2 |
ctd
No evidence text available
20382639
ctd
No evidence text available
19150397
YOD1 affects transport
| 2
YOD1-C160S activates transport. 1 / 1
| 1
reach
"The results showed that the active site mutant of YOD1 (C160S) inhibited the reverse transport of various misfolded proteins, and results showed that the accumulation of RI332 in YOD1 (C160S) cells (without deubiquitination activity) was much higher than that in YOD1 wild-type cells [XREF_BIBR]."
33546413
YOD1 activates transport. 1 / 1
| 1
reach
"Studies have shown that YOD1 negatively regulates the reverse transport of CTA1, and the mechanism of action may be the deubiquitination of some ERAD components that promote reverse transport of the protein rather than substrate ubiquitination."
33546413
YOD1 affects phosphor-Smad2/3
| 2
YOD1 increases the amount of phosphor-Smad2/3.
| 1
YOD1 increases the amount of phosphor-Smad2/3. 1 / 1
| 1
reach
"Furthermore, we have found that YOD1 siRNA decreases the mRNA levels of TGF-β3 and protein levels of phosphor-Smad2/3."
30345304
YOD1 decreases the amount of phosphor-Smad2/3.
| 1
YOD1 decreases the amount of phosphor-Smad2/3. 1 / 1
| 1
reach
"The results have shown that RNAi of YOD1 reduces TGF-β3 and phosphor-Smad2/3 expression."
30345304
YOD1 affects phospho-Smad2/3
| 2
YOD1 increases the amount of phospho-Smad2/3.
| 1
YOD1 increases the amount of phospho-Smad2/3. 1 / 1
| 1
reach
"The results of our study have shown that silencing of YOD1 by RNAi in HOK cells inhibits protein level of phosphor-Smad2/3 which may be associated with inhibition of TGF-β3 expression by YOD1 siRNA.Our data suggest that YOD1 siRNA will reduce the expression levels of TGF-β3 and phospho-Smad2/3."
30345304
YOD1 deubiquitinates phospho-Smad2/3.
| 1
YOD1 leads to the deubiquitination of phospho-Smad2/3. 1 / 1
| 1
reach
"YOD1 siRNA may enhance the ubiquitylation of TGF-β3 and phospho-Smad2/3 and then result in the downregulation of TGF-β signaling.The mechanism of inhibition of cell proliferation and migration caused by YOD1 siRNA may be associated with TGF-β3 signaling pathway, which is involved in NSCL/P."
30345304
YOD1 affects pathway
| 2
YOD1 inhibits pathway. 2 / 2
| 2
sparser
"M2 macrophage-derived EVs are taken up by CD8 + T cells and facilitate CD8 + T cell exhaustion by targeting YOD1, which inactivates the YAP/β-catenin pathway."
35185900
sparser
"YOD1 inactivated the YAP/β-catenin pathway."
34282135
YOD1 affects YOD1
| 1
YOD1 decreases the amount of YOD1. 1 / 2
| 1
reach
"As shown in XREF_FIG, compared with the scrambled control siRNA (si-Scr), YOD1 siRNA (si-YOD1) successfully suppressed YOD1 expression in both sham- and CVB3 infected cells, and this suppression correlated well with each corresponding decrease of desmin protein."
24722419
YOD1 affects YAP1
| 2
YOD1 inhibits YAP1. 2 / 2
| 2
reach
"YOD1 inhibited the YAP/beta-catenin pathway."
34282135
reach
"YOD1 inactivated the YAP/beta-catenin pathway."
34282135
YOD1 affects Ubx
| 2
TRAF6 binds YOD1 and Ubx. 1 / 1
| 1
sparser
"However, neither exchange of the conserved glutamic acid to alanine (YOD1 E96A) nor even more profound mutations of the putative TRAF6 binding motif abolished YOD1 association ( xref and xref ), indicating that binding of TRAF6 MATH to YOD1 UBX domain is not mediated through a typical TIM."
28244869
VCP binds YOD1 and Ubx. 1 / 1
| 1
sparser
"The DUB YOD1, which binds to p97 via its UBX (ubiquitin regulatory X) domain, is also associated with ERAD [ xref ]."
28819009
YOD1 affects UBX domain
| 2
VCP binds YOD1 and UBX domain. 2 / 2
| 2
reach
"YOD1, the mammalian homolog of Otu1, also interacts with p97 through its UBX domain [XREF_BIBR]."
28159894
reach
"YOD1 interacts with p97 via its UBX domain."
21468305
YOD1 affects TGFB3
| 2
YOD1 increases the amount of TGFB3.
| 1
Modified YOD1 increases the amount of TGFB3. 1 / 1
| 1
reach
"The mRNA and protein levels of TGF-beta3 were increased by YOD1 overexpression."
30145984
YOD1 activates TGFB3.
| 1
YOD1 activates TGFB3. 1 / 1
| 1
reach
"YOD1 overexpression enhances cell migration by promoting TGF-beta3 signaling which may play an important role in lip and palate formation."
30145984
YOD1 affects RIPK1
1 | 1
YOD1 inhibits RIPK1.
| 1
YOD1 inhibits RIPK1. 1 / 1
| 1
reach
"OTUD2 was also able to reduce the polyUb RIP1 signal, but, in this experiment, it can not be assessed whether OTUD2 also released polyUb chains."
23827681
YOD1 binds RIPK1.
1 |
RIPK1 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
23827681
YOD1 affects OTUB1
| 2
OTUB1 binds YOD1. 2 / 2
| 2
sparser
"Superimpositions of TYMV PRO/DUB with cellular OTU DUBs show that yeast OTU1 and human OTUD2 also interact simultaneously with the two hydrophobic patches of Ub (Fig. S3A) but engage mainly hydrophobic residues, together with one charged residue that structurally resembles Arg844 of TYMV PRO/DUB, i.e. Glu203 in yOTU1 or Arg245 in hOTUD2 (Fig. S3)."
32732284
sparser
"Superimpositions of TYMV PRO/DUB with cellular OTU DUBs show that yeast OTU1 and human OTUD2 also interact simultaneously with the two hydrophobic patches of Ub () but engage mainly hydrophobic residues, together with one charged residue that structurally resembles Arg 844 of TYMV PRO/DUB, i.e. Glu 203 in yOTU1 or Arg 245 in hOTUD2 ()."
32732284
YOD1 affects NPLOC4
1 | 1
VCP binds NPLOC4, YOD1, and Ufd1. 1 / 1
| 1
sparser
"In a screen for potential functional partners of YOD1, Ernst et al. discovered an interaction between YOD1 and the p97-Ufd1-Npl4 complex, linking this DUB to the ERQC pathway [ xref ]."
22812527
NPLOC4 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19818707
YOD1 affects NEDD4
1 | 1
YOD1 deubiquitinates NEDD4.
| 1
YOD1 deubiquitinates NEDD4. 1 / 1
| 1
reach
"YOD1 Deubiquitinates NEDD4 Involved in the Hippo Signaling Pathway."
31916733
YOD1 binds NEDD4.
1 |
YOD1 binds NEDD4. 1 / 1
1 |
biogrid
No evidence text available
23827681
YOD1 affects MIR21
| 2
YOD1 inhibits MIR21.
| 1
YOD1 inhibits MIR21. 1 / 1
| 1
reach
"The overexpression of YOD1 almost eliminated the effect of miR-21 on desmin degradation as evidenced by the equivalent levels of desmin in miR-CL and miR-21 transfected cells in the presence of a YOD1 expression plasmid."
24722419
YOD1 activates MIR21.
| 1
YOD1 activates MIR21. 1 / 1
| 1
reach
"To verify whether YOD1 is a true target of miR-21, we first measured the expression level of YOD1 in miR-21 mimic transfected cells without CVB3 infection."
24722419
YOD1 affects K6-, K11-, K29-, K33-,
| 2
YOD1 deubiquitinates K6-, K11-, K29-, K33-,.
| 1
YOD1 deubiquitinates K6-, K11-, K29-, K33-, on K63. 1 / 1
| 1
reach
"In the current study, we found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein."
36682332
YOD1 binds K6-, K11-, K29-, K33-,.
| 1
YOD1 binds K6-, K11-, K29-, K33-, and K63. 1 / 1
| 1
reach
"In the current study, we found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein."
36682332
YOD1 affects K11
| 2
YOD1 binds OTUD3 and K11. 1 / 1
| 1
sparser
"Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."
27066941
YOD1 binds K11. 1 / 1
| 1
sparser
"These findings can be reconciled from available OTUD2 structures, in particular from a structure of OTUD2 bound to K11-linked diUb, in which Ub moieties interact with S1 and S2 sites of the enzyme (Figure 4F)."
27066941
YOD1 affects IKK_complex
| 2
YOD1 ubiquitinates IKK_complex.
| 1
YOD1 leads to the ubiquitination of IKK_complex. 1 / 1
| 1
reach
"Clearly, YOD1 deficiency alone is not sufficient to induce TRAF6 ubiquitination or IKK and NF-kappaB signaling in the absence of any stimulation."
28244869
YOD1 inhibits IKK_complex.
| 1
YOD1 inhibits IKK_complex. 1 / 1
| 1
reach
"Further, IL-1 triggered IKK and NF-kappaB signaling and induction of target genes is decreased by YOD1 overexpression and augmented after YOD1 depletion."
28244869
YOD1 affects E3_Ub_ligase
| 1 1
E3_Ub_ligase binds YOD1. 2 / 2
| 1 1
sparser
"The YOD1 deubiquitinase binds to the Hrd1 E3 ubiquitin ligase."
24068323
reach
"The YOD1 deubiquitinase binds to the Hrd1 E3 ubiquitin ligase."
24068323
YOD1 affects CD40
| 1
YOD1 activates CD40. 1 / 2
| 1
reach
"However, why and how YOD1 promotes canonical NF-kappaB signaling and activation in the context of p62 independent CD40 or RANK stimulation is currently unclear and we can only speculate."
28244869
YOD1 affects CCDC51
2 |
YOD1 binds CCDC51. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
YOD1 affects BLNK
| 2
TRAF binds TRAF6, BLNK, and YOD1. 1 / 1
| 1
sparser
"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
31797949
TRAF6 binds BLNK, YOD1, and TraF. 1 / 1
| 1
sparser
"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
28244869
VCP affects UBX domain
| 2
VCP binds YOD1 and UBX domain. 2 / 2
| 2
reach
"YOD1, the mammalian homolog of Otu1, also interacts with p97 through its UBX domain [XREF_BIBR]."
28159894
reach
"YOD1 interacts with p97 via its UBX domain."
21468305
Ubx affects YOD1
| 2
TRAF6 binds YOD1 and Ubx. 1 / 1
| 1
sparser
"However, neither exchange of the conserved glutamic acid to alanine (YOD1 E96A) nor even more profound mutations of the putative TRAF6 binding motif abolished YOD1 association ( xref and xref ), indicating that binding of TRAF6 MATH to YOD1 UBX domain is not mediated through a typical TIM."
28244869
VCP binds YOD1 and Ubx. 1 / 1
| 1
sparser
"The DUB YOD1, which binds to p97 via its UBX (ubiquitin regulatory X) domain, is also associated with ERAD [ xref ]."
28819009
Ubiquitin affects YOD1
| 2
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
Ubiquitin binds YOD1. 1 / 1
| 1
sparser
"Several of these residues are solvent exposed in Ub, suggesting that OTUD2 binds to these residues of the proximal Ub."
23827681
UBX domain affects YOD1
| 2
VCP binds YOD1 and UBX domain. 2 / 2
| 2
reach
"YOD1, the mammalian homolog of Otu1, also interacts with p97 through its UBX domain [XREF_BIBR]."
28159894
reach
"YOD1 interacts with p97 via its UBX domain."
21468305
TRAF6 affects IL1
| 2
IL1 binds TRAF6 and YOD1. 2 / 2
| 2
sparser
"Indeed, it seemed likely that in this overexpression scenario there was slightly augmented association of TRAF6 and YOD1 WT after short IL-1 stimulation."
28244869
sparser
"In fact, IL-1-induced TRAF6 ubiquitination correlates with a decreased binding of YOD1 to TRAF6 after IL-1 stimulation (see xref and xref ), and we asked, whether reduced binding is also visible at the level of endogenous proteins in HeLa cells and primary HUVEC cells ( xref )."
28244869
TRAF6 affects BLNK
| 2
TRAF binds TRAF6, BLNK, and YOD1. 1 / 1
| 1
sparser
"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
31797949
TRAF6 binds BLNK, YOD1, and TraF. 1 / 1
| 1
sparser
"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
28244869
OTUB1 affects YOD1
| 2
OTUB1 binds YOD1. 2 / 2
| 2
sparser
"Superimpositions of TYMV PRO/DUB with cellular OTU DUBs show that yeast OTU1 and human OTUD2 also interact simultaneously with the two hydrophobic patches of Ub (Fig. S3A) but engage mainly hydrophobic residues, together with one charged residue that structurally resembles Arg844 of TYMV PRO/DUB, i.e. Glu203 in yOTU1 or Arg245 in hOTUD2 (Fig. S3)."
32732284
sparser
"Superimpositions of TYMV PRO/DUB with cellular OTU DUBs show that yeast OTU1 and human OTUD2 also interact simultaneously with the two hydrophobic patches of Ub () but engage mainly hydrophobic residues, together with one charged residue that structurally resembles Arg 844 of TYMV PRO/DUB, i.e. Glu 203 in yOTU1 or Arg 245 in hOTUD2 ()."
32732284
NPLOC4 affects YOD1
1 | 1
VCP binds NPLOC4, YOD1, and Ufd1. 1 / 1
| 1
sparser
"In a screen for potential functional partners of YOD1, Ernst et al. discovered an interaction between YOD1 and the p97-Ufd1-Npl4 complex, linking this DUB to the ERQC pathway [ xref ]."
22812527
NPLOC4 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19818707
K11 affects YOD1
| 2
YOD1 binds OTUD3 and K11. 1 / 1
| 1
sparser
"Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."
27066941
YOD1 binds K11. 1 / 1
| 1
sparser
"These findings can be reconciled from available OTUD2 structures, in particular from a structure of OTUD2 bound to K11-linked diUb, in which Ub moieties interact with S1 and S2 sites of the enzyme (Figure 4F)."
27066941
IL1 affects YOD1
| 2
IL1 binds TRAF6 and YOD1. 2 / 2
| 2
sparser
"Indeed, it seemed likely that in this overexpression scenario there was slightly augmented association of TRAF6 and YOD1 WT after short IL-1 stimulation."
28244869
sparser
"In fact, IL-1-induced TRAF6 ubiquitination correlates with a decreased binding of YOD1 to TRAF6 after IL-1 stimulation (see xref and xref ), and we asked, whether reduced binding is also visible at the level of endogenous proteins in HeLa cells and primary HUVEC cells ( xref )."
28244869
FIRRE affects YOD1
| 1 1
FIRRE increases the amount of YOD1.
| 1
FIRRE increases the amount of YOD1. 1 / 1
| 1
reach
"Mechanistically, FIRRE modulated YOD1 expression by sponging miR-520a-3p, thus contributing to the development of GBC."
34168678
FIRRE activates YOD1.
| 1
FIRRE activates YOD1. 1 / 1
| 1
eidos
"Mechanistically , FIRRE modulated YOD1 expression by sponging miR-520a-3p , thus contributing to the development of GBC ."
34168678
E3_Ub_ligase affects YOD1
| 1 1
E3_Ub_ligase binds YOD1. 2 / 2
| 1 1
sparser
"The YOD1 deubiquitinase binds to the Hrd1 E3 ubiquitin ligase."
24068323
reach
"The YOD1 deubiquitinase binds to the Hrd1 E3 ubiquitin ligase."
24068323
CCDC51 affects YOD1
2 |
YOD1 binds CCDC51. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
BLNK affects YOD1
| 2
TRAF binds TRAF6, BLNK, and YOD1. 1 / 1
| 1
sparser
"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
31797949
TRAF6 binds BLNK, YOD1, and TraF. 1 / 1
| 1
sparser
"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
28244869
2,3,7,8-tetrachlorodibenzodioxine increases the amount of YOD1.
1 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
32109520
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of YOD1.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
25975270
Urethane affects YOD1
1 |
Urethane increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
28818685
Trichostatin A affects YOD1
1 |
Trichostatin A decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
24935251
Titanium dioxide affects YOD1
1 |
Titanium dioxide decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
29264374
Tetrachloromethane affects YOD1
1 |
Tetrachloromethane increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
31150632
Sponging miR-520a-3p contributing development GBC affects YOD1
| 1
Sponging miR-520a-3p contributing development GBC activates YOD1. 1 / 1
| 1
eidos
"Mechanistically , FIRRE modulated YOD1 expression by sponging miR-520a-3p , thus contributing to the development of GBC ."
34168678
Sodium dodecyl sulfate increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
31734321
Schizandrin B affects YOD1
1 |
Schizandrin B increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
31150632
Proteasome inhibitor affects YOD1
| 1
Proteasome inhibitor activates YOD1. 1 / 1
| 1
reach
"Treatment of proteasome inhibitor blocked the effect of YOD1 siRNAs on desmin suppression, suggesting that YOD1 is essential to stabilize desmin."
24722419
Phenobarbital affects YOD1
1 |
Phenobarbital increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
19270015
Perfluorooctanoic acid increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
23978341
Perfluorooctane-1-sulfonic acid decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
27153767
Pentachlorophenol affects YOD1
1 |
Pentachlorophenol increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
23892564
Neurogenic proteins affects YOD1
| 1
Neurogenic proteins activates YOD1. 1 / 1
| 1
eidos
"Moreover , YOD1 level upregulation was reported to be induced by neurogenic proteins , causing Huntington 's disease and PD ."
34956196
MiR-4429 affects YOD1
| 1
MiR-4429 increases the amount of YOD1. 1 / 1
| 1
reach
"By negatively regulating YOD1 level, miR-4429 suppresses the malignant development of ovarian cancer."
32964960
MiR-190a-3p affects YOD1
| 1
MiR-190a-3p decreases the amount of YOD1. 1 / 1
| 1
reach
"Besides, a series of mechanism experiments then proved that miR-190a-3p negatively regulates YOD1 expression."
34527075
Melphalan affects YOD1
1 |
Melphalan increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
22363485
Let-7 affects YOD1
| 1
YOD1 binds let-7. 1 / 1
| 1
sparser
"Our analysis of miRNA–gene functional interaction, pointed to the existence of a molecular regulation mechanism in platelets, which was inferred based on the topology of the interaction network formed by recently emerged miRNAs (miR-103a-3p, miR-423-5p, and miR-92a-3p) and conserved miRNAs of the let-7 family interacting with the YOD1 gene, a desubiquitinating enzyme that is very expressed in platelet hyperactivity [ xref ]."
32806499
Jinfukang affects YOD1
1 |
Jinfukang decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
27392435
Indometacin affects YOD1
1 |
Indometacin decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
16984733
Hsa-miR-9-3p affects YOD1
1 |
Hsa-miR-9-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-877-5p affects YOD1
1 |
Hsa-miR-877-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-875-3p affects YOD1
1 |
Hsa-miR-875-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-8086 affects YOD1
1 |
Hsa-miR-8086 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-8069 affects YOD1
1 |
Hsa-miR-8069 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-8061 affects YOD1
1 |
Hsa-miR-8061 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-8054 affects YOD1
1 |
Hsa-miR-8054 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-7157-5p affects YOD1
1 |
Hsa-miR-7157-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6882-5p affects YOD1
1 |
Hsa-miR-6882-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6875-3p affects YOD1
1 |
Hsa-miR-6875-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6866-5p affects YOD1
1 |
Hsa-miR-6866-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6804-5p affects YOD1
1 |
Hsa-miR-6804-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6776-5p affects YOD1
1 |
Hsa-miR-6776-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-676-5p affects YOD1
1 |
Hsa-miR-676-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6754-3p affects YOD1
1 |
Hsa-miR-6754-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6741-5p affects YOD1
1 |
Hsa-miR-6741-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6733-3p affects YOD1
1 |
Hsa-miR-6733-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6718-5p affects YOD1
1 |
Hsa-miR-6718-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-670-5p affects YOD1
1 |
Hsa-miR-670-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-655-3p affects YOD1
1 |
Hsa-miR-655-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6516-5p affects YOD1
1 |
Hsa-miR-6516-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6507-3p affects YOD1
1 |
Hsa-miR-6507-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-576-5p affects YOD1
1 |
Hsa-miR-576-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-5692c affects YOD1
1 |
Hsa-miR-5692c decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-5692b affects YOD1
1 |
Hsa-miR-5692b decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-559 affects YOD1
1 |
Hsa-miR-559 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-5589-5p affects YOD1
1 |
Hsa-miR-5589-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-551b-5p affects YOD1
1 |
Hsa-miR-551b-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-550b-2-5p affects YOD1
1 |
Hsa-miR-550b-2-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-550a-5p affects YOD1
1 |
Hsa-miR-550a-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-550a-3p affects YOD1
1 |
Hsa-miR-550a-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-550a-3-5p affects YOD1
1 |
Hsa-miR-550a-3-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-548y affects YOD1
1 |
Hsa-miR-548y decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548w affects YOD1
1 |
Hsa-miR-548w decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548o-5p affects YOD1
1 |
Hsa-miR-548o-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548l affects YOD1
1 |
Hsa-miR-548l decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548k affects YOD1
1 |
Hsa-miR-548k decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548j-5p affects YOD1
1 |
Hsa-miR-548j-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548i affects YOD1
1 |
Hsa-miR-548i decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548h-5p affects YOD1
1 |
Hsa-miR-548h-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548d-5p affects YOD1
1 |
Hsa-miR-548d-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548c-5p affects YOD1
1 |
Hsa-miR-548c-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548bb-5p affects YOD1
1 |
Hsa-miR-548bb-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548b-5p affects YOD1
1 |
Hsa-miR-548b-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ay-5p affects YOD1
1 |
Hsa-miR-548ay-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548av-5p affects YOD1
1 |
Hsa-miR-548av-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548au-5p affects YOD1
1 |
Hsa-miR-548au-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548as-5p affects YOD1
1 |
Hsa-miR-548as-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ar-5p affects YOD1
1 |
Hsa-miR-548ar-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548aq-5p affects YOD1
1 |
Hsa-miR-548aq-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ap-5p affects YOD1
1 |
Hsa-miR-548ap-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548am-5p affects YOD1
1 |
Hsa-miR-548am-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ak affects YOD1
1 |
Hsa-miR-548ak decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ae-5p affects YOD1
1 |
Hsa-miR-548ae-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ad-5p affects YOD1
1 |
Hsa-miR-548ad-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548ab affects YOD1
1 |
Hsa-miR-548ab decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548a-5p affects YOD1
1 |
Hsa-miR-548a-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-526b-3p affects YOD1
1 |
Hsa-miR-526b-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-520h affects YOD1
1 |
Hsa-miR-520h decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-520g-3p affects YOD1
1 |
Hsa-miR-520g-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-520f-3p affects YOD1
1 |
Hsa-miR-520f-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-513b-3p affects YOD1
1 |
Hsa-miR-513b-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-498 affects YOD1
1 |
Hsa-miR-498 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4760-5p affects YOD1
1 |
Hsa-miR-4760-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4735-5p affects YOD1
1 |
Hsa-miR-4735-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4732-3p affects YOD1
1 |
Hsa-miR-4732-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4731-5p affects YOD1
1 |
Hsa-miR-4731-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4728-3p affects YOD1
1 |
Hsa-miR-4728-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4727-3p affects YOD1
1 |
Hsa-miR-4727-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4711-3p affects YOD1
1 |
Hsa-miR-4711-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4680-3p affects YOD1
1 |
Hsa-miR-4680-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4659b-3p affects YOD1
1 |
Hsa-miR-4659b-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4659a-3p affects YOD1
1 |
Hsa-miR-4659a-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-449c-3p affects YOD1
1 |
Hsa-miR-449c-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4460 affects YOD1
1 |
Hsa-miR-4460 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4455 affects YOD1
1 |
Hsa-miR-4455 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4429 affects YOD1
1 |
Hsa-miR-4429 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4319 affects YOD1
1 |
Hsa-miR-4319 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4312 affects YOD1
1 |
Hsa-miR-4312 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4310 affects YOD1
1 |
Hsa-miR-4310 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4263 affects YOD1
1 |
Hsa-miR-4263 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-412-3p affects YOD1
1 |
Hsa-miR-412-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-3973 affects YOD1
1 |
Hsa-miR-3973 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-374c-5p affects YOD1
1 |
Hsa-miR-374c-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-374b-5p affects YOD1
1 |
Hsa-miR-374b-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-374a-5p affects YOD1
1 |
Hsa-miR-374a-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3692-5p affects YOD1
1 |
Hsa-miR-3692-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3691-3p affects YOD1
1 |
Hsa-miR-3691-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-369-3p affects YOD1
1 |
Hsa-miR-369-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3678-3p affects YOD1
1 |
Hsa-miR-3678-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-361-5p affects YOD1
1 |
Hsa-miR-361-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-34a-5p affects YOD1
1 |
Hsa-miR-34a-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-324-5p affects YOD1
1 |
Hsa-miR-324-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-320d affects YOD1
1 |
Hsa-miR-320d decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-320c affects YOD1
1 |
Hsa-miR-320c decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-320b affects YOD1
1 |
Hsa-miR-320b decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-320a affects YOD1
1 |
Hsa-miR-320a decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3160-5p affects YOD1
1 |
Hsa-miR-3160-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3145-3p affects YOD1
1 |
Hsa-miR-3145-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3120-3p affects YOD1
1 |
Hsa-miR-3120-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-30b-5p affects YOD1
1 |
Hsa-miR-30b-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-298 affects YOD1
1 |
Hsa-miR-298 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-26b-5p affects YOD1
1 |
Hsa-miR-26b-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19088304
Hsa-miR-24-3p affects YOD1
1 |
Hsa-miR-24-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-2392 affects YOD1
1 |
Hsa-miR-2392 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-221-3p affects YOD1
1 |
Hsa-miR-221-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-218-2-3p affects YOD1
1 |
Hsa-miR-218-2-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-203b-5p affects YOD1
1 |
Hsa-miR-203b-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-200c-5p affects YOD1
1 |
Hsa-miR-200c-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-197-3p affects YOD1
1 |
Hsa-miR-197-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-181a-5p affects YOD1
1 |
Hsa-miR-181a-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-181a-2-3p affects YOD1
1 |
Hsa-miR-181a-2-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-140-5p affects YOD1
1 |
Hsa-miR-140-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1303 affects YOD1
1 |
Hsa-miR-1303 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-1283 affects YOD1
1 |
Hsa-miR-1283 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1273h-3p affects YOD1
1 |
Hsa-miR-1273h-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-1271-3p affects YOD1
1 |
Hsa-miR-1271-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-125b-5p affects YOD1
1 |
Hsa-miR-125b-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-1255b-2-3p affects YOD1
1 |
Hsa-miR-1255b-2-3p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-1193 affects YOD1
1 |
Hsa-miR-1193 decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-10a-5p affects YOD1
1 |
Hsa-miR-10a-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-106a-5p affects YOD1
1 |
Hsa-miR-106a-5p decreases the amount of YOD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Gold atom affects YOD1
1 |
Gold atom decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
25523186
Flutamide affects YOD1
1 |
Flutamide increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
24793618
ctd
No evidence text available
29464035
Endosulfan affects YOD1
1 |
Endosulfan increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
29391264
reach
"In addition, no splicing of the XBP1 transcription factor mRNA was observed when YOD1 was knocked down, in contrast to cells treated with the well established ER stress-inducers tunicamycin and dithiothreitol (DTT; XREF_FIG, compare lanes 3 and 4 with lanes 1 and 5)."
24068323
Dioxygen affects YOD1
1 |
Dioxygen increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
22629407
Cyclosporin A affects YOD1
1 |
Cyclosporin A increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
25562108
Copper atom affects YOD1
1 |
Copper atom increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
20971185
Cdc48 affects YOD1
| 1
YOD1 binds cdc48. 1 / 1
| 1
reach
"yOtu1 and D.melanogaster (dm) Otu1 are orthologs of human OTUD2 (38% and 53% identical in OTU domain, respectively), and OTUD2 and yOtu1 both bind cdc48 and p97 and are involved in endoplasmic-reticulum-associated protein degradation."
23827681
Benzo[a]pyrene affects YOD1
1 |
Benzo[a]pyrene increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
20064835
Atrazine affects YOD1
1 |
Atrazine increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
25929836
Aflatoxin M1 affects YOD1
1 |
Aflatoxin M1 decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
30928695
Aflatoxin B1 affects YOD1
1 |
Aflatoxin B1 increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
19770486
YP_009227202 affects YOD1
1 |
YOD1 binds YP_009227202. 1 / 1
1 |
virhostnet
No evidence text available
30037810
YP_009227199 affects YOD1
1 |
YOD1 binds YP_009227199. 1 / 1
1 |
virhostnet
No evidence text available
30037810
YOD1 affects α-synuclein
| 1
YOD1 deubiquitinates α-synuclein. 1 / 1
| 1
reach
"Deubiquitinating enzyme YOD1 deubiquitinates and destabilizes α-synuclein."
36682332
YOD1 affects ubiquitination abnormal proteins
| 1
YOD1 inhibits ubiquitination abnormal proteins. 1 / 1
| 1
eidos
"Neurogenic proteins stimulated YOD1 expression , which caused a reduction in the ubiquitination of abnormal proteins [ 149 ] ."
| PMC
YOD1 affects ubiquitin-proteasome
| 1
YOD1 activates ubiquitin-proteasome. 1 / 1
| 1
reach
"Overall, such data suggest that the deubiquitinase YOD1 contributes to the pathogenesis of neurodegenerative disease by affecting the ubiquitin-proteasome system and autophagy-lysosome pathway."
33343629
YOD1 affects substrate
| 1
YOD1 inhibits substrate. 1 / 1
| 1
eidos
"They speculated that YOD1 eliminated the obstacles to the attachment of the Ub chain through its deubiquitination activity , enabling the substrate to successfully complete the transport ( Figure 2n ) ."
33546413
YOD1 affects stability ITCH
| 1
YOD1 activates stability ITCH. 1 / 1
| 1
eidos
"A recent study reported that YOD1 could deubiquitinate ITCH , and enhanced the stability of ITCH , which subsequently reduced the levels of LATS and increased the YAP / TAZ level ."
34315490
YOD1 affects signaling
| 1
YOD1 inhibits signaling. 1 / 1
| 1
sparser
"YOD1 appears to inhibit TRAF6 by a noncatalytic mechanism since the YOD1 C160S mutant still inhibits IL-1-NF-κB signaling."
28244869
YOD1 inhibits signal transduction. 1 / 1
| 1
reach
"YOD1 RNAi inhibits TGF-β3 signaling pathway to suppress cell proliferation and migration contributing to NSCL/P."
30345304
YOD1 affects proteotoxicity
| 1
YOD1 inhibits proteotoxicity. 1 / 1
| 1
eidos
"Recently , one of the DUBs , YOD1 , was suggested to decrease proteotoxicity in HD ."
| PMC
YOD1 affects prion-like aggregates
| 1
YOD1 inhibits prion-like aggregates. 1 / 1
| 1
eidos
"Importantly , the ubiquitin thioesterase OTU1 ( YOD1 ) cleaves the K63-linked ubiquitin moiety and abrogates the formation of prion-like aggregates by MAVS , thereby attenuating IRF3-mediated production of IFN-beta64 ."
34782737
YOD1 affects prion
| 1
YOD1 inhibits prion. 1 / 1
| 1
reach
"Subsequently, YOD1 cleaved the K63 linked ubiquitination and abrogated the formation of prion like aggregates of MAVS, which led to attenuation of IRF3, P65 activation, and IFN-beta production."
30952814
YOD1 affects pr1
| 1
YOD1 inhibits pr1. 1 / 1
| 1
reach
"Similarly, co-expression with the dominant negative mammalian deubiquitinylase YOD1 (YOD1-C160S) [37] or the dominant negative mutant of the AAA p97 ATPase, which lacks ATPase activity (p97QQ, E305 and E578 mutated into Q) [38], blocked degradation of pr1 from construct 2A*, which accumulated intracellularly further confirming degradation through the ubiquitin–proteasome pathway (Fig. 5e)."
30367842
YOD1 affects obstacles
| 1
YOD1 inhibits obstacles. 1 / 1
| 1
eidos
"They speculated that YOD1 eliminated the obstacles to the attachment of the Ub chain through its deubiquitination activity , enabling the substrate to successfully complete the transport ( Figure 2n ) ."
33546413
YOD1 affects model ERAD substrates
| 1
YOD1 inhibits model ERAD substrates. 1 / 1
| 1
reach
"Transfection of a catalytically inactive form of YOD1 blocks dislocation of model ERAD substrates XREF_BIBR."
21468305
YOD1 affects migration human oral
| 1
YOD1 activates migration human oral. 1 / 1
| 1
eidos
"We have shown that knockdown of YOD1 by RNAi inhibits the proliferation and migration of human oral keratinocytes ( HOK ) cells ."
30345304
YOD1 affects migration cells
| 1
YOD1 activates migration cells. 1 / 1
| 1
eidos
"In conclusion , we have shown that the downregulation of YOD1 using RNAi inhibits proliferation and migration of HOK cells , which involve inhibiting the TGF-beta3 signaling pathway ."
30345304
YOD1 affects miR-373
| 1
YOD1 activates miR-373. 1 / 1
| 1
reach
"Transient transfection of SiHa cells with those wild-type or mutant vectors and miR-373 or mock control resulted in partial rescue of the inhibition, further supporting that YOD1 is a direct target of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25747718
YOD1 affects let-7
| 1
YOD1 binds let-7. 1 / 1
| 1
sparser
"Our analysis of miRNA–gene functional interaction, pointed to the existence of a molecular regulation mechanism in platelets, which was inferred based on the topology of the interaction network formed by recently emerged miRNAs (miR-103a-3p, miR-423-5p, and miR-92a-3p) and conserved miRNAs of the let-7 family interacting with the YOD1 gene, a desubiquitinating enzyme that is very expressed in platelet hyperactivity [ xref ]."
32806499
YOD1 affects interleukin-1
| 1
YOD1 inhibits interleukin-1. 1 / 1
| 1
reach
"YOD1 antagonizes ubiquitin ligase TRAF6 and p62 dependent interleukin-1 signaling to NF-kappaB."
33343629
reach
"Knockdown of YOD1 potentiated IRF3 and P65 activation, IFN-beta production, and antiviral innate immune response to RNA virus."
30952814
YOD1 affects immune response
| 1
YOD1 activates immune response. 1 / 1
| 1
reach
"Liu and colleagues reported YOD1 mediated K63 linked deubiquitination could activate an innate antiviral immune response against viral infection, and the aggregation of MAVS."
33343629
YOD1 affects gallbladder cancer
| 1
eidos
"LncRNA FIRRE promotes the progression of gallbladder cancer by mediating the expression of YOD1 through a ceRNA mechanism ( 32 ) ."
35693714
reach
"A dominant negative version of the deubiquitylating enzyme Yod1 (Yod1C160S) causes accumulation of dislocation substrates in the ER."
22619172
YOD1 affects depending YAP TAZ
| 1
YOD1 activates depending YAP TAZ. 1 / 1
| 1
eidos
"YOD1 promoted the proliferation of hepatocytes and led to hepatomegaly depending on the YAP / TAZ activity [ 36 ] ."
34315490
YOD1 affects cell growth
| 1
YOD1 inhibits cell growth. 1 / 1
| 1
reach
"In addition, it was revealed that the overexpression of YOD1 could significantly abrogate miR-373-induced cell growth in SiHa cells."
25747718
YOD1 affects cdc48
| 1
YOD1 binds cdc48. 1 / 1
| 1
reach
"yOtu1 and D.melanogaster (dm) Otu1 are orthologs of human OTUD2 (38% and 53% identical in OTU domain, respectively), and OTUD2 and yOtu1 both bind cdc48 and p97 and are involved in endoplasmic-reticulum-associated protein degradation."
23827681
YOD1 affects beta3 signaling pathway
| 1
YOD1 activates beta3 signaling pathway. 1 / 1
| 1
eidos
"RNA interference and overexpression experiments indicated that YOD1 could enhance cell migration during lip and palate formation through the transforming growth factor ( TGF ) - beta3 signaling pathway ( Zhou et al ., 2018 ) ."
33343629
YOD1 affects association
| 1
YOD1 inhibits association. 1 / 1
| 1
sparser
"Indeed, co-IP experiments using MYC-TRAF6 together with Crimson-p62 and GFP-YOD1 revealed that YOD1 was able to inhibit the association of TRAF6 and p62, while p62 did not alter the binding of YOD1 to TRAF6 ( xref )."
28244869
YOD1 affects aggregation MAVS
| 1
YOD1 inhibits aggregation MAVS. 1 / 1
| 1
eidos
"Subsequently , YOD1 removes the K63-linked ubiquitin chain and abrogates the aggregation of MAVS , thus inhibiting not only IRF3 and p65 activation , but also IFN-beta production ."
33511009
YOD1 affects YP_009227202
1 |
YOD1 binds YP_009227202. 1 / 1
1 |
virhostnet
No evidence text available
30037810
YOD1 affects YP_009227199
1 |
YOD1 binds YP_009227199. 1 / 1
1 |
virhostnet
No evidence text available
30037810
YOD1 affects YAP/β-catenin
| 1
YOD1 inhibits YAP/β-catenin. 1 / 1
| 1
reach
"Briefly, YOD1 inhibited the YAP/β-catenin pathway."
34282135
YOD1 affects Ufd1
| 1
VCP binds NPLOC4, YOD1, and Ufd1. 1 / 1
| 1
sparser
"In a screen for potential functional partners of YOD1, Ernst et al. discovered an interaction between YOD1 and the p97-Ufd1-Npl4 complex, linking this DUB to the ERQC pathway [ xref ]."
22812527
YOD1 affects Ub smear
| 1
YOD1 inhibits Ub smear. 1 / 1
| 1
reach
"YOD1, which hydrolyzes primarily the atypical K6, K11, K27, K29, and K33 linkages, was able to partially reduce the Ub smear when used at high concentrations (XREF_SUPPLEMENTARY G)."
28919039
YOD1 affects Ub chains
| 1
YOD1 activates Ub chains. 1 / 1
| 1
reach
"Multiple lysines in the diUb probe can serve as coupling sites and accordingly USP2 and YOD1, which can cleave a number of different Ub linkages, lead to complete and partial digestion of the Ub chains, respectively."
28919039
YOD1 affects USP21
1 |
USP21 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
YOD1 affects USP15
1 |
USP15 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
YOD1 affects UFD1
1 |
UFD1 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19818707
YOD1 affects UBX2
| 1
YOD1 binds UBX2. 1 / 1
| 1
sparser
"Using this approach, we identified Derlin-1 and UBXD8 as novel interaction partners of YOD1, while SEL1 and UBXD2 apparently do not interact with YOD1 ( xref and data not shown)."
19818707
YOD1 affects UBE3A
1 |
UBE3A binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
23827681
YOD1 affects UBE2J1
1 |
UBE2J1 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
20435896
YOD1 affects TraF
| 1
TRAF6 binds BLNK, YOD1, and TraF. 1 / 1
| 1
sparser
"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
28244869
YOD1 affects TRM1
1 |
YOD1 binds TRM1. 1 / 1
1 |
virhostnet
No evidence text available
31873071
YOD1 affects TRIM63
1 |
TRIM63 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
YOD1 affects TRIM55
1 |
TRIM55 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
YOD1 affects TRIM54
1 |
TRIM54 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
YOD1 affects TRAF
| 1
TRAF binds TRAF6, BLNK, and YOD1. 1 / 1
| 1
sparser
"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
31797949
YOD1 affects TRA
1 |
TRA binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
24068323
YOD1 affects THOC3
1 |
THOC3 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
YOD1 affects TAZ
| 1
YOD1 activates TAZ. 1 / 1
| 1
reach
"Deubiquitinase YOD1 potentiates YAP and TAZ activities through enhancing ITCH stability."
28416659
YOD1 affects SYT1
| 1
YOD1 activates SYT1. 1 / 1
| 1
reach
"Knockdown of YOD1 potentiated IRF3 and P65 activation, IFN-beta production, and antiviral innate immune response to RNA virus."
30952814
YOD1 affects SNCA
| 1
SNCA binds YOD1. 1 / 1
| 1
sparser
"In the current study, we found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein."
36682332
YOD1 affects SHARPIN
1 |
YOD1 binds SHARPIN. 1 / 1
1 |
biogrid
No evidence text available
28244869
YOD1 affects RP23-306D20.1
1 |
YOD1 binds RP23-306D20.1. 1 / 1
1 |
biogrid
No evidence text available
26496610
YOD1 affects RAR
| 1
YOD1 activates RAR. 1 / 1
| 1
reach
"Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells."
35847510
YOD1 affects RAR alpha
| 1
YOD1 activates RAR alpha. 1 / 1
| 1
eidos
"Suppression of YOD1 promoted the degradation of PML / RAR alpha , thus inhibiting APL cells and prolonging the survival time of APL cell-bearing mice ."
35847510
YOD1 affects Parkinson Disease
| 1
reach
"Moreover, YOD1 level upregulation was reported to be induced by neurogenic proteins, causing Huntington’s disease and PD."
34956196
YOD1 affects POLD1
1 |
YOD1 binds POLD1. 1 / 1
1 |
biogrid
No evidence text available
26496610
YOD1 affects PML
| 1
YOD1 activates PML. 1 / 1
| 1
reach
"Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells."
35847510
YOD1 affects PFKM
1 |
YOD1 binds PFKM. 1 / 1
1 |
biogrid
No evidence text available
26344197
YOD1 affects OTUD3
| 1
YOD1 binds OTUD3 and K11. 1 / 1
| 1
sparser
"Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."
27066941
YOD1 affects NFKBIA
| 1
YOD1 activates NFKBIA. 1 / 1
| 1
reach
"Downregulation of TRAF6 or p62 prevented IkappaBalpha degradation and YOD1 depletion enhanced IkappaBalpha removal upon IL-1beta stimulation, demonstrating that all proteins affect NF-kappaB signaling (XREF_FIG)."
28244869
YOD1 affects Mice
| 1
YOD1 inhibits Mice. 1 / 1
| 1
reach
"Suppression of YOD1 promoted the degradation of PML/RAR α , thus inhibiting APL cells and prolonging the survival time of APL cell-bearing mice."
35847510
YOD1 affects MATH
| 1
YOD1 binds MATH. 1 / 1
| 1
reach
"However, neither exchange of the conserved glutamic acid to alanine (YOD1 E96A) nor even more profound mutations of the putative TRAF6 binding motif abolished YOD1 association (XREF_FIG and XREF_FIG), indicating that binding of TRAF6 MATH to YOD1 UBX domain is not mediated through a typical TIM."
28244869
YOD1 affects LAMP1
| 1
YOD1 binds LAMP1. 1 / 1
| 1
sparser
"Another UBX-L-containing DUB, YOD1, has been associated with lysosomal autophagy and ERAD [ xref , xref ]."
28819009
YOD1 affects K63
| 1
YOD1 binds K6-, K11-, K29-, K33-, and K63. 1 / 1
| 1
reach
"In the current study, we found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein."
36682332
YOD1 affects K33
| 1
YOD1 binds K11-and and K33. 1 / 1
| 1
reach
"Article Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets.Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."
27066941
YOD1 affects ISG15
| 1
UBXN6 binds YOD1, ISG15, and PLAA. 1 / 1
| 1
sparser
"In addition, several cofactors of VCP were found to interact with ISG15 such as the VCP-UFD1-NPL4 protein complex as well as PLAA, UBXN6 and YOD1 44 , FAF1, NSFL1C, UBXN1, and RNF115 [45] [46] [47] [48] ."
34599178
YOD1 affects IRF3-mediated IFN-beta64
| 1
YOD1 inhibits IRF3-mediated IFN-beta64. 1 / 1
| 1
eidos
"Importantly , the ubiquitin thioesterase OTU1 ( YOD1 ) cleaves the K63-linked ubiquitin moiety and abrogates the formation of prion-like aggregates by MAVS , thereby attenuating IRF3-mediated production of IFN-beta64 ."
34782737
YOD1 affects IRF3-mediated IFN-beta
| 1
YOD1 inhibits IRF3-mediated IFN-beta. 1 / 1
| 1
eidos
"Importantly , the ubiquitin thioesterase OTU1 ( YOD1 ) cleaves the K63-linked ubiquitin moiety and abrogates the formation of prion-like aggregates by MAVS , thereby attenuating IRF3-mediated production of IFN-beta 64 ."
34782737
YOD1 affects IRF3
| 1
YOD1 activates IRF3. 1 / 1
| 1
reach
"Knockdown of YOD1 potentiated IRF3 and P65 activation, IFN-beta production, and antiviral innate immune response to RNA virus."
30952814
YOD1 affects IL1R1
| 1
YOD1 inhibits IL1R1. 1 / 1
| 1
reach
"While DOX treatment alone did not significantly alter expression of these genes in HeLa parental cells (XREF_FIG), expression of YOD1 WT or C160S caused a significant decline in NF-kappaB target gene induction after IL-1beta stimulation, indicating that YOD1 can antagonize IL-1R triggered NF-kappaB signaling independent of its catalytic activity."
28244869
YOD1 affects IFNB1
| 1
YOD1 activates IFNB1. 1 / 1
| 1
reach
"Knockdown of YOD1 potentiated IRF3 and P65 activation, IFN-beta production, and antiviral innate immune response to RNA virus."
30952814
YOD1 affects Hepatocytes
| 1
YOD1 activates Hepatocytes. 1 / 1
| 1
eidos
"YOD1 promoted the proliferation of hepatocytes and led to hepatomegaly depending on the YAP / TAZ activity [ 36 ] ."
34315490
YOD1 affects HOKs
| 1
YOD1 activates HOKs. 1 / 1
| 1
reach
"YOD1 overexpression significantly enhanced the migration of HOKs."
30145984
YOD1 affects Gln-Gln
| 1
YOD1 deubiquitinates Gln-Gln. 1 / 1
| 1
reach
"p97 QQ associated polyubiquitinated proteins can be deubiquitinated in vitro by purified YOD1 (XREF_SUPPLEMENTARY)."
19818707
YOD1 affects FLT3 inhibitors
| 1
YOD1 inhibits FLT3 inhibitors. 1 / 1
| 1
reach
"Finally, overexpression of YOD1 stabilized p53, upregulated pro-apoptotic p53 downstream genes, and increased the sensitivity of AML cells to FLT3 inhibitors remarkably."
37454155
YOD1 affects FCF1
1 |
FCF1 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
28514442
YOD1 affects FAM98B
1 |
YOD1 binds FAM98B. 1 / 1
1 |
biogrid
No evidence text available
26344197
YOD1 affects ERAD
| 1
YOD1 activates ERAD. 1 / 1
| 1
reach
"Ubiquitin thioesterase OTU1, which is involved in the UPR and participates in the ubiquitin-related ERAD process (Gaudet et al., 2011), was significantly increased in this study (ratio = 1.2102), indicating the enhancement of ERAD to ameliorate ER pressure."
35492579
YOD1 affects ER
| 1
YOD1-C160S inhibits ER. 1 / 1
| 1
reach
"We blocked dislocation from the ER by the expression of YOD1 C160S, which causes stabilization of ER resident, glycosylated RI 332 XREF_BIBR."
21468303
YOD1 affects ELAVL1
1 |
YOD1 binds ELAVL1. 1 / 1
1 |
biogrid
No evidence text available
19322201
YOD1 affects Cdc48
| 1
YOD1 binds Cdc48. 1 / 1
| 1
reach
"In addition, whereas both H. sapiens YOD1 and OTUD2 and S. cerevisiae Otu1 interact with p97 and Cdc48 through an N-terminal UBL or UBX domain, the A. thaliana OTU2 has a relatively shorter N-terminus and does not interact with CDC48."
24659992
YOD1 affects CFAP97
| 1
YOD1 binds CFAP97. 1 / 1
| 1
sparser
"Importantly, this HMW signal was absent when FLAG-C160S YOD1 was purified under a denaturing condition (i.e., 1% SDS; xref , third panel, compare lane 4 with lane 3), indicating that the HMW signal is due to polyubiquitinated proteins noncovalently associated with YOD1 and not polyubiquitination of YOD1."
24068323
YOD1 affects CD3δ
| 1
YOD1 binds CD3δ. 1 / 1
| 1
sparser
"Catalytically inactive YOD1 binds and stabilizes ubiquitinated CD3δ."
24417208
YOD1 affects CD3delta
| 1
YOD1 binds ubiquitinated CD3delta. 1 / 1
| 1
reach
"Catalytically inactive YOD1 binds and stabilizes ubiquitinated CD3delta."
24417208
YOD1 affects BLOC1S5
1 |
BLOC1S5 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
YOD1 affects BIRC3
1 |
YOD1 binds BIRC3. 1 / 1
1 |
biogrid
No evidence text available
28244869
YOD1 affects Arg-Ile
| 1
YOD1-C160S activates Arg-Ile. 1 / 1
| 1
reach
"We showed previously that YOD1 C160S causes complete retention of RI 332 in the ER, a substrate otherwise extracted and targeted for degradation (XREF_FIG) XREF_BIBR."
21468303
YOD1 affects ATXN3
| 1
YOD1 binds ATXN3. 1 / 1
| 1
sparser
"Through direct interactions with VCP/p97, ataxin-3 and YOD1 function after VCP/p97 is recruited to the ER membrane xref , xref , xref ."
22590560
Vehicle Emissions affects YOD1
1 |
Vehicle Emissions demethylates YOD1. 1 / 1
1 |
ctd
No evidence text available
25560391
VCP affects Ufd1
| 1
VCP binds NPLOC4, YOD1, and Ufd1. 1 / 1
| 1
sparser
"In a screen for potential functional partners of YOD1, Ernst et al. discovered an interaction between YOD1 and the p97-Ufd1-Npl4 complex, linking this DUB to the ERQC pathway [ xref ]."
22812527
VCP affects Ubx
| 1
VCP binds YOD1 and Ubx. 1 / 1
| 1
sparser
"The DUB YOD1, which binds to p97 via its UBX (ubiquitin regulatory X) domain, is also associated with ERAD [ xref ]."
28819009
VCP affects TRAF6
| 1
TRAF6 binds VCP and YOD1. 1 / 1
| 1
sparser
"Despite some weak interaction with cIAP2 and SHARPIN, within this panel YOD1 was quite selectively binding to p97 and TRAF6."
28244869
VCP affects NPLOC4
| 1
VCP binds NPLOC4, YOD1, and Ufd1. 1 / 1
| 1
sparser
"In a screen for potential functional partners of YOD1, Ernst et al. discovered an interaction between YOD1 and the p97-Ufd1-Npl4 complex, linking this DUB to the ERQC pathway [ xref ]."
22812527
Ubx affects VCP, and YOD1
| 1
VCP binds YOD1 and Ubx. 1 / 1
| 1
sparser
"The DUB YOD1, which binds to p97 via its UBX (ubiquitin regulatory X) domain, is also associated with ERAD [ xref ]."
28819009
Ubx affects TRAF6
| 1
TRAF6 binds YOD1 and Ubx. 1 / 1
| 1
sparser
"However, neither exchange of the conserved glutamic acid to alanine (YOD1 E96A) nor even more profound mutations of the putative TRAF6 binding motif abolished YOD1 association ( xref and xref ), indicating that binding of TRAF6 MATH to YOD1 UBX domain is not mediated through a typical TIM."
28244869
Ubiquitin affects UBXN6
| 1
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
USP21 affects YOD1
1 |
USP21 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP15 affects YOD1
1 |
USP15 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
UFD1 affects YOD1
1 |
UFD1 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19818707
UBXN6 affects Ubiquitin
| 1
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
UBXN6 affects ISG15
| 1
UBXN6 binds YOD1, ISG15, and PLAA. 1 / 1
| 1
sparser
"In addition, several cofactors of VCP were found to interact with ISG15 such as the VCP-UFD1-NPL4 protein complex as well as PLAA, UBXN6 and YOD1 44 , FAF1, NSFL1C, UBXN1, and RNF115 [45] [46] [47] [48] ."
34599178
UBX2 affects YOD1
| 1
YOD1 binds UBX2. 1 / 1
| 1
sparser
"Using this approach, we identified Derlin-1 and UBXD8 as novel interaction partners of YOD1, while SEL1 and UBXD2 apparently do not interact with YOD1 ( xref and data not shown)."
19818707
UBE3A affects YOD1
1 |
UBE3A binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
23827681
UBE2J1 affects YOD1
1 |
UBE2J1 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
20435896
TraF affects YOD1
| 1
TRAF6 binds BLNK, YOD1, and TraF. 1 / 1
| 1
sparser
"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
28244869
TRM1 affects YOD1
1 |
YOD1 binds TRM1. 1 / 1
1 |
virhostnet
No evidence text available
31873071
TRIM63 affects YOD1
1 |
TRIM63 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
TRIM55 affects YOD1
1 |
TRIM55 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
TRIM54 affects YOD1
1 |
TRIM54 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
TRAF6 affects VCP, and YOD1
| 1
TRAF6 binds VCP and YOD1. 1 / 1
| 1
sparser
"Despite some weak interaction with cIAP2 and SHARPIN, within this panel YOD1 was quite selectively binding to p97 and TRAF6."
28244869
TRAF6 affects Ubx, and YOD1
| 1
TRAF6 binds YOD1 and Ubx. 1 / 1
| 1
sparser
"However, neither exchange of the conserved glutamic acid to alanine (YOD1 E96A) nor even more profound mutations of the putative TRAF6 binding motif abolished YOD1 association ( xref and xref ), indicating that binding of TRAF6 MATH to YOD1 UBX domain is not mediated through a typical TIM."
28244869
TRAF6 affects TraF
| 1
TRAF6 binds BLNK, YOD1, and TraF. 1 / 1
| 1
sparser
"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
28244869
TRAF6 affects TRAF2
| 1
TRAF2 binds TRAF6 and YOD1. 1 / 1
| 1
sparser
"To assess the selectivity of YOD1/TRAF6 interaction, we compared association of YOD1 to TRAF2 and TRAF6 in HEK293 cells ( xref )."
28244869
TRAF6 affects TRAF
| 1
TRAF binds TRAF6, BLNK, and YOD1. 1 / 1
| 1
sparser
"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
31797949
TRAF2 affects TRAF6, and YOD1
| 1
TRAF2 binds TRAF6 and YOD1. 1 / 1
| 1
sparser
"To assess the selectivity of YOD1/TRAF6 interaction, we compared association of YOD1 to TRAF2 and TRAF6 in HEK293 cells ( xref )."
28244869
TRAF affects YOD1
| 1
TRAF binds TRAF6, BLNK, and YOD1. 1 / 1
| 1
sparser
"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
31797949
TRA affects YOD1
1 |
TRA binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
24068323
THOC3 affects YOD1
1 |
THOC3 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
TGF-beta3 mRNA affects YOD1
| 1
TGF-beta3 mRNA inhibits YOD1. 1 / 1
| 1
reach
"The TGF-beta3 mRNA and protein levels were decreased significantly by siRNA-mediated knockdown of YOD1."
30345304
TAZ affects YOD1
| 1
TAZ activates YOD1. 1 / 1
| 1
reach
"To identify deubiquitinase (s) that regulates Hippo signaling, we performed unbiased siRNA screening and found that YOD1 controls biological responses mediated by YAP and TAZ."
28416659
SNCA affects YOD1
| 1
SNCA binds YOD1. 1 / 1
| 1
sparser
"In the current study, we found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein."
36682332
SHARPIN affects YOD1
1 |
YOD1 binds SHARPIN. 1 / 1
1 |
biogrid
No evidence text available
28244869
RP23-306D20.1 affects YOD1
1 |
YOD1 binds RP23-306D20.1. 1 / 1
1 |
biogrid
No evidence text available
26496610
RIPK1 affects YOD1
1 |
RIPK1 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
23827681
Pentosan Sulfuric Polyester increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
28973697
Parkinson diseases affects YOD1
| 1
Parkinson diseases activates YOD1. 1 / 1
| 1
eidos
"Tanji et al. demonstrated that the neurogenic proteins that cause Huntington and Parkinson 's diseases induced upregulation of the YOD1 level ( Tanji et al ., 2018 ) ."
33343629
POLD1 affects YOD1
1 |
YOD1 binds POLD1. 1 / 1
1 |
biogrid
No evidence text available
26496610
PLAA affects Ubiquitin
| 1
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
PLAA affects UBXN6, and YOD1
| 1
UBXN6 binds YOD1 and PLAA. 1 / 1
| 1
sparser
"While p97 (Valosin-containing protein) translocates to the lysosome to form a complex with UBXD1, PLAA, and YOD1."
33114389
PLAA affects UBXN6, Ubiquitin, and YOD1
| 1
Ubiquitin binds UBXN6, YOD1, and PLAA. 1 / 1
| 1
sparser
"The latter is part of a complex with YOD1, UBXD1 and PLAA, that removes K48-linked ubiquitin and thus emphasises the presence of K63-linked ubiquitin, which is preferred by the autophagy machinery xref , xref ."
32047650
PLAA affects ISG15
| 1
UBXN6 binds YOD1, ISG15, and PLAA. 1 / 1
| 1
sparser
"In addition, several cofactors of VCP were found to interact with ISG15 such as the VCP-UFD1-NPL4 protein complex as well as PLAA, UBXN6 and YOD1 44 , FAF1, NSFL1C, UBXN1, and RNF115 [45] [46] [47] [48] ."
34599178
PFKM affects YOD1
1 |
YOD1 binds PFKM. 1 / 1
1 |
biogrid
No evidence text available
26344197
OTUD3 affects YOD1
| 1
YOD1 binds OTUD3 and K11. 1 / 1
| 1
sparser
"Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."
27066941
Neurogenic proteins affects YOD1
| 1
Neurogenic proteins activates YOD1. 1 / 1
| 1
eidos
"Neurogenic proteins stimulated YOD1 expression , which caused a reduction in the ubiquitination of abnormal proteins [ 149 ] ."
| PMC
NSC 689534 affects YOD1
1 |
NSC 689534 increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
20971185
NPLOC4 affects VCP
| 1
VCP binds NPLOC4, YOD1, and Ufd1. 1 / 1
| 1
sparser
"In a screen for potential functional partners of YOD1, Ernst et al. discovered an interaction between YOD1 and the p97-Ufd1-Npl4 complex, linking this DUB to the ERQC pathway [ xref ]."
22812527
NONHSAT210528 affects YOD1
| 1
NONHSAT210528 increases the amount of YOD1. 1 / 1
| 1
reach
"Conversely, the overexpression of NONHSAT210528 promoted the expression of the YOD1 protein, but NONHSAT210528 did not promote the expression of YOD1 protein when miR-21-5p was knocked down (see Figure 8D)."
35693714
NFkappaB affects YOD1
| 1
NFkappaB activates YOD1. 1 / 1
| 1
reach
"Next, we examined direct effects on canonical NF-kappaB signaling in YOD1 KO clones in the absence (mock) or the presence of YOD1 (XREF_FIG and XREF_FIG)."
28244869
NEDD4 affects YOD1
1 |
YOD1 binds NEDD4. 1 / 1
1 |
biogrid
No evidence text available
23827681
MAVS affects YOD1
| 1
YOD1 binds MAVS. 1 / 1
| 1
sparser
"After viral infection, OTUD2 (also known as YOD1) interacts with MAVS through its UBX and Znf domains at the mitochondria, followed by the cleavage the K63-linked ubiquitin chains of MAVS that induced the abrogation of MAVS oligomerization to attenuate the IFN production [ xref ]."
35008917
MATH affects YOD1
| 1
YOD1 binds MATH. 1 / 1
| 1
reach
"However, neither exchange of the conserved glutamic acid to alanine (YOD1 E96A) nor even more profound mutations of the putative TRAF6 binding motif abolished YOD1 association (XREF_FIG and XREF_FIG), indicating that binding of TRAF6 MATH to YOD1 UBX domain is not mediated through a typical TIM."
28244869
LncRNA-TUG1 affects YOD1
| 1
LncRNA-TUG1 activates YOD1. 1 / 1
| 1
reach
"YY1-induced LncRNA-TUG1 elevates YOD1 to promote cell proliferation and inhibit bortezomib sensitivity in multiple myeloma."
37078241
LAMP1 affects YOD1
| 1
YOD1 binds LAMP1. 1 / 1
| 1
sparser
"Another UBX-L-containing DUB, YOD1, has been associated with lysosomal autophagy and ERAD [ xref , xref ]."
28819009
K63 affects YOD1
| 1
YOD1 binds K6-, K11-, K29-, K33-, and K63. 1 / 1
| 1
reach
"In the current study, we found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein."
36682332
K33 affects YOD1
| 1
YOD1 binds K11-and and K33. 1 / 1
| 1
reach
"Article Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets.Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."
27066941
K11 affects OTUD3, and YOD1
| 1
YOD1 binds OTUD3 and K11. 1 / 1
| 1
sparser
"Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."
27066941
JNK affects YOD1
| 1
JNK activates YOD1. 1 / 1
| 1
reach
"Thus, normal JNK signaling in YOD1 knock-down cells further supports the notion that YOD1 is selectively acting on p62 and TRAF6 complexes."
28244869
ISG15 affects YOD1
| 1
UBXN6 binds YOD1, ISG15, and PLAA. 1 / 1
| 1
sparser
"In addition, several cofactors of VCP were found to interact with ISG15 such as the VCP-UFD1-NPL4 protein complex as well as PLAA, UBXN6 and YOD1 44 , FAF1, NSFL1C, UBXN1, and RNF115 [45] [46] [47] [48] ."
34599178
IL1B affects YOD1
| 1
IL1B activates YOD1. 1 / 1
| 1
reach
"Again, we analyzed expression of NF-kappaB target genes upon IL-1beta stimulation in YOD1 expressing (minus DOX) or depleted (plus DOX) HeLa cells (XREF_FIG)."
28244869
Huntington affects YOD1
| 1
Huntington activates YOD1. 1 / 1
| 1
eidos
"Tanji et al. demonstrated that the neurogenic proteins that cause Huntington and Parkinson 's diseases induced upregulation of the YOD1 level ( Tanji et al ., 2018 ) ."
33343629
GSK-J4 affects YOD1
1 |
GSK-J4 increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
29301935
FMR4 affects YOD1
| 1
FMR4 activates YOD1. 1 / 1
| 1
reach
"We found that FMR4 overexpression significantly upregulated two putative targets, the deubiquitinase YOD1 and the G protein subunit GNG12, and downregulated the ribonucleotide reductase RRM2."
26322075
FCF1 affects YOD1
1 |
FCF1 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
28514442
FAM98B affects YOD1
1 |
YOD1 binds FAM98B. 1 / 1
1 |
biogrid
No evidence text available
26344197
ELAVL1 affects YOD1
1 |
YOD1 binds ELAVL1. 1 / 1
1 |
biogrid
No evidence text available
19322201
Deubiquitinase affects YOD1
| 1
Deubiquitinase activates YOD1. 1 / 1
| 1
eidos
"Therefore , we speculate that YOD1 may also be involved in the TGF-beta signaling pathway due to the activity of DUB , which plays a role in NSCL / P progression through affecting the embryonic development and differentiation ."
30345304
DHX33 affects PPP2CA, PROX1, SEMA4B, SP1, and YOD1
| 1
SEMA4B binds SP1, DHX33, YOD1, PPP2CA, and PROX1. 1 / 1
| 1
sparser
"It has been reported that miR-670-5p was associated with hepatocellular carcinoma by modulating PROX1 expression at the posttranscriptional level. xref We predicted 21 candidate genes as the possible targets of miR-670-5p, of which PPP2CA , YOD1 , PROX1 , SEMA4B , DHX33 , and SP1 were associated with tumor proliferation, migration, or invasion according to the published literature. xref – xref "
30881124
Cdc48 affects YOD1
| 1
YOD1 binds Cdc48. 1 / 1
| 1
reach
"In addition, whereas both H. sapiens YOD1 and OTUD2 and S. cerevisiae Otu1 interact with p97 and Cdc48 through an N-terminal UBL or UBX domain, the A. thaliana OTU2 has a relatively shorter N-terminus and does not interact with CDC48."
24659992
CFAP97 affects YOD1
| 1
YOD1 binds CFAP97. 1 / 1
| 1
sparser
"Importantly, this HMW signal was absent when FLAG-C160S YOD1 was purified under a denaturing condition (i.e., 1% SDS; xref , third panel, compare lane 4 with lane 3), indicating that the HMW signal is due to polyubiquitinated proteins noncovalently associated with YOD1 and not polyubiquitination of YOD1."
24068323
CD3δ affects YOD1
| 1
YOD1 binds CD3δ. 1 / 1
| 1
sparser
"Catalytically inactive YOD1 binds and stabilizes ubiquitinated CD3δ."
24417208
CD3delta affects YOD1
| 1
YOD1 binds ubiquitinated CD3delta. 1 / 1
| 1
reach
"Catalytically inactive YOD1 binds and stabilizes ubiquitinated CD3delta."
24417208
BLOC1S5 affects YOD1
1 |
BLOC1S5 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
BLNK affects TraF
| 1
TRAF6 binds BLNK, YOD1, and TraF. 1 / 1
| 1
sparser
"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
28244869
BLNK affects TRAF, TRAF6, and YOD1
| 1
TRAF binds TRAF6, BLNK, and YOD1. 1 / 1
| 1
sparser
"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
31797949
BIRC3 affects YOD1
1 |
YOD1 binds BIRC3. 1 / 1
1 |
biogrid
No evidence text available
28244869
Antigens, Polyomavirus Transforming increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
26680231
ATXN3 affects YOD1
| 1
YOD1 binds ATXN3. 1 / 1
| 1
sparser
"Through direct interactions with VCP/p97, ataxin-3 and YOD1 function after VCP/p97 is recruited to the ER membrane xref , xref , xref ."
22590560
3,4-methylenedioxymethamphetamine increases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
20188158
2-hydroxypropanoic acid decreases the amount of YOD1. 1 / 1
1 |
ctd
No evidence text available
30851411
ctd
No evidence text available
28903501