IndraLab

Statements

USP6 affects NFkappaB
| 1 5 24
USP6 activates NFkappaB. 10 / 30
| 1 5 24
sparser
"Here we demonstrate that TRE17 activates canonical p65-containing NF-κB through an atypical mechanism that is independent of IκB phosphorylation/degradation."
22081069
sparser
"IκB-SR completely abrogated activation of NF-κB by TRE17 as determined by EMSA ( xref )."
22081069
reach
"We previously reported that USP6 activates NF-kappaB, and that NF-kappaB plays an essential role in USP6 mediated transformation."
27440725
eidos
"In these models , activation of STAT3 , NF-kappaB , and beta-catenin by USP6 was essential for tumorigenesis , as genetic or pharmacologic inhibition of these pathways significantly attenuated xenograft growth ( 16 , 23 , 24 ) ."
33558334
sparser
"In these models, activation of STAT3, NF-κB, and β-catenin by USP6 was essential for tumorigenesis, as genetic or pharmacologic inhibition of these pathways significantly attenuated xenograft growth ( xref , xref , xref )."
33558334
sparser
"We recently reported that TRE17 activates NF-κB, in a manner dependent on its USP activity ( xref )."
22081069
sparser
"Optimal activation of NF-κB by TRE17 requires both catalytic subunits of IKK, distinguishing its mechanism from the classical and non-canonical pathways, which require either IKKβ or IKKα, respectively."
22081069
reach
"This USP6 dependent activation of NF-kappaB requires IKKalpha, IKKbeta and NEMO in order for p65 S536 phosphorylation to take place."
26999213
sparser
"We recently reported that activation of NF-κB by TRE17 is mediated in part by RhoA and ROCK ( xref )."
22081069
reach
"Activation of NF-kappaB by USP6 was completely suppressed in these cells (XREF_FIG, left), in accordance with our previous results."
27440725
USP6 affects STAT3
| 7 12
USP6 activates STAT3.
| 7 9
USP6 activates STAT3. 10 / 16
| 7 9
reach
"Jak1 in this clone was reduced to levels approximating those in control NIH3T3 cells (XREF_SUPPLEMENTARY), demonstrating that upregulation of Jak1 by USP6 is required for full activation of STAT3 by USP6."
27440725
sparser
"Given that NF-κB and STAT3 are often activated coordinately during tumorigenesis, we examined whether STAT3 was activated by USP6 in our established cellular models of ABC and NF."
27440725
reach
"This validates our cellular model systems, and indicates that USP6 expression in human tumors triggers STAT3 and NF-kappaB signaling responses."
27440725
sparser
"In these models, activation of STAT3, NF-κB, and β-catenin by USP6 was essential for tumorigenesis, as genetic or pharmacologic inhibition of these pathways significantly attenuated xenograft growth ( xref , xref , xref )."
33558334
sparser
"We sought to dissect the mechanism by which USP6 activates STAT3."
27440725
sparser
"Jak kinases mediate STAT3 activation by USP6 and are required for tumorigenesis."
27440725
sparser
"Jak1 in this clone was reduced to levels approximating those in control NIH3T3 cells ( xref ), demonstrating that upregulation of Jak1 by USP6 is required for full activation of STAT3 by USP6."
27440725
reach
"USP6 activates STAT3 in cellular models and USP6 translocated tumors."
27440725
reach
"Given that NF-kappaB and STAT3 are often activated coordinately during tumorigenesis, we examined whether STAT3 was activated by USP6 in our established cellular models of ABC and NF."
27440725
reach
"We sought to dissect the mechanism by which USP6 activates STAT3."
27440725
USP6 phosphorylates STAT3.
| 3
USP6 phosphorylates STAT3. 3 / 3
| 3
sparser
"As shown in xref , the pan-Jak inhibitor blocked USP6-induced phosphorylation of STAT3 in a dose-dependent manner, but had no effect on tyrosine phosphorylation induced by Src or the EGF receptor."
27440725
sparser
"USP6-induced STAT3 phosphorylation was completely abrogated in cells depleted of Jak1 (USP6/J1#17)."
27440725
sparser
"A pan-Jak inhibitor completely blocked USP6-induced phosphorylation of STAT3, while the pan-Src PP2 inhibitor was ineffectual ( xref )."
27440725
USP6 affects MYH9
| 17
USP6 binds MYH9. 10 / 17
| 17
sparser
"Histologically, the lesion was consistent with nodular fasciitis, and the detection of the MYH9-USP6 fusion gene supported the diagnosis."
33282285
sparser
"We detected a MYH9-USP6 fusion in the two hip cases and a COL1A1-USP6 fusion in the shoulder case."
33404853
sparser
"The MYH9-USP6 fusion gene was recently detected in nodular fasciitis, and nodular fasciitis is now considered to be a self-limiting neoplastic process."
33282285
sparser
"Among the benign F/M tumours, nodular fasciitis, previously considered a reactive process, is now definitively established as a self-limiting neoplasm associated with rapid growth and ultimately spontaneous regression over the course of months based on MYH9-USP6 gene fusion [ xref ]."
32999693
sparser
"The MYH9-USP6 fusion gene was detected in 1 case (1/8) of the cellular FTSs, while no target fusion partner was detected in the classic FTS."
36973197
sparser
"The common MYH9-USP6 rearrangement was detected in four cases; another case had a rare alternative fusion with CTNNB1."
34099872
sparser
"USP6 gene rearrangement has been recently demonstrated in nodular fasciitis and this rearrangement may lead to the formation of a fusion gene MYH9-USP6 in some cases."
26882059
sparser
"Nodular fasciitis has been historically regarded as a reactive process, given its self-limiting nature, but is now thought to be neoplastic owing to the identification of recurrent translocation t(17;22)(p13;q13) that results in MYH9-USP6 fusion. xref "
28745570
sparser
"MYH9-USP6 fusion confirmed the diagnosis of 2 NFs >5 cm with prominent ischemic necrosis."
33000481
sparser
"USP6 gene rearrangement was found in six cases and MYH9-USP6 gene fusion in two cases."
33915654
USP6 affects COL1A1
| 17
USP6 binds COL1A1. 10 / 17
| 17
sparser
"RNASeq further detected COL1A1-USP6 fusion in six cases and a novel ANGPTL2-USP6 fusion in one case."
32157177
sparser
"In addition to histological features consistent with MOC, PCR analysis identified the transcript COL1A1-USP6, recently reported in some cases of MOC [6]."
35434525
sparser
"Previous cytogenetic with subsequent RNA sequencing studies xref , xref in two STABCs showed COL1A1-USP6 fusion involving exon 1 of COL1A1 and a splicing variant of USP6 exon 1 or exon 2."
32157177
sparser
"Sharing COL1A1-USP6 fusion, FO and FOPD exhibited similar central or haphazard bone matrix deposition."
33000481
sparser
"Molecular analysis revealed the presence of COL1A1-USP6 transcript X-ray scans: note right soft tissue neck opacity compared with left side, indicating swelling (A, white arrow)"
35434525
sparser
"Majority of cases show COL1A1–USP6 fusion and herein we have described an additional case with ANGPTL2 gene as a novel fusion partner with USP6 ."
32157177
sparser
"Pathology revealed the presence of muscular tissue mixed with fibroblastic/myofibroblastic proliferation and ossification areas consistent with myositis ossificans (Fig. 4); COL1A1-USP6 fusion transcript upon molecular investigation by RT-PCR method was found."
35434525
sparser
"COL1A1-USP6 fusion was predominant in ossifying lesions, including all FOs, MOs, ST-ABCs, and FOPDs with identified partner genes, and also present in non-ossifying head and neck NFs (HN-NFs) and C-FTSs in 2 cases each."
33000481
sparser
"We detected a MYH9-USP6 fusion in the two hip cases and a COL1A1-USP6 fusion in the shoulder case."
33404853
sparser
"Notably, we believed that FO may demonstrate more similar clinicopathologic and genetic manifestations with MO/FOPD and ST-ABC instead of nodular fasciitis for involving lower limbs most frequently and showing recurrent COL1A1::USP6 fusion."
36727055
USP6 affects ARF6
1 2 | 3 11
USP6 binds ARF6.
2 | 2 11
USP6 binds ARF6. 10 / 14
2 | 2 10
sparser
"It has been found that the TBC domain of TRE17 binds Arf6-GDP ( xref )."
17145964
sparser
"Via its TRE-2/Bub2/CDC16 (TBC) domain, TRE17 preferentially interacts with ARF6-GDP at tubular endosomes and facilitates its recycling to the PM ( xref )."
30042195
biogrid
No evidence text available
15509780
sparser
"Second, it was recently reported that the TBC domain of TRE17 binds to Arf6-GDP ( xref )."
17145964
sparser
"TRE17 binding to ARF6 increases its activation 50 ; although TRE17 does not itself have GEF activity towards ARF6, it may facilitate interaction of ARF6 with another GEF."
21587297
reach
"TRE17 binding to ARF6 increases its activation ; although TRE17 does not itself have GEF activity towards ARF6, it may facilitate interaction of ARF6 with another GEF."
21587297
sparser
"Based on our observation of internalization of CD147 prior to TRE17-mediated trafficking ( xref ) and the preferential binding of TRE17 to ARF6-GDP ( xref ), the former is more likely, as ARF6 undergoes GTP hydrolysis at SEs via interaction with the ACAP1/2 GAPs ( xref )."
30042195
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
sparser
"USP6 interacts with Arf6 through its N-terminus Tre2/Bub2/Csc16 (TBC) domain, and depletion of USP6 decreases Arf6 activity [19]."
| PMC
sparser
"If cargo such as MHC-I or CD98 was directed by infection into EEA1 membranes of a heterotypic SE, then it might be shielded or out of the reach of TRE17, which specifically associates with ARF6-GDP ( xref )."
30042195
USP6 binds ARF6 and EPI64. 1 / 1
| 1
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
USP6 activates ARF6.
1 | 1
USP6 activates ARF6. 2 / 2
1 | 1
reach
"USP6 interacts with Arf6 through its N-terminus Tre2/Bub2/Csc16 (TBC) domain, and depletion of USP6 decreases Arf6 activity [19]."
| PMC
signor
"Here we show that tre17 (also called tre-2 and usp6), a founding member of the tbc family, targets the arf family gtpase arf6, which regulates plasma membrane-endosome trafficking. Surprisingly, tre17 does not function as a gap for arf6 but rather promotes its activation in vivo. Forced expression of tre17 promotes the localization of arf6 to the plasma membrane, leading to arf6 activation, presumably due to facilitated access to membrane-associated guanine nucleotide exchange factors (gefs)."
15509780
MYH9 affects USP6
| 17
USP6 binds MYH9. 10 / 17
| 17
sparser
"Histologically, the lesion was consistent with nodular fasciitis, and the detection of the MYH9-USP6 fusion gene supported the diagnosis."
33282285
sparser
"We detected a MYH9-USP6 fusion in the two hip cases and a COL1A1-USP6 fusion in the shoulder case."
33404853
sparser
"The MYH9-USP6 fusion gene was recently detected in nodular fasciitis, and nodular fasciitis is now considered to be a self-limiting neoplastic process."
33282285
sparser
"Among the benign F/M tumours, nodular fasciitis, previously considered a reactive process, is now definitively established as a self-limiting neoplasm associated with rapid growth and ultimately spontaneous regression over the course of months based on MYH9-USP6 gene fusion [ xref ]."
32999693
sparser
"The MYH9-USP6 fusion gene was detected in 1 case (1/8) of the cellular FTSs, while no target fusion partner was detected in the classic FTS."
36973197
sparser
"The common MYH9-USP6 rearrangement was detected in four cases; another case had a rare alternative fusion with CTNNB1."
34099872
sparser
"USP6 gene rearrangement has been recently demonstrated in nodular fasciitis and this rearrangement may lead to the formation of a fusion gene MYH9-USP6 in some cases."
26882059
sparser
"Nodular fasciitis has been historically regarded as a reactive process, given its self-limiting nature, but is now thought to be neoplastic owing to the identification of recurrent translocation t(17;22)(p13;q13) that results in MYH9-USP6 fusion. xref "
28745570
sparser
"MYH9-USP6 fusion confirmed the diagnosis of 2 NFs >5 cm with prominent ischemic necrosis."
33000481
sparser
"USP6 gene rearrangement was found in six cases and MYH9-USP6 gene fusion in two cases."
33915654
COL1A1 affects USP6
| 17
USP6 binds COL1A1. 10 / 17
| 17
sparser
"RNASeq further detected COL1A1-USP6 fusion in six cases and a novel ANGPTL2-USP6 fusion in one case."
32157177
sparser
"In addition to histological features consistent with MOC, PCR analysis identified the transcript COL1A1-USP6, recently reported in some cases of MOC [6]."
35434525
sparser
"Previous cytogenetic with subsequent RNA sequencing studies xref , xref in two STABCs showed COL1A1-USP6 fusion involving exon 1 of COL1A1 and a splicing variant of USP6 exon 1 or exon 2."
32157177
sparser
"Sharing COL1A1-USP6 fusion, FO and FOPD exhibited similar central or haphazard bone matrix deposition."
33000481
sparser
"Molecular analysis revealed the presence of COL1A1-USP6 transcript X-ray scans: note right soft tissue neck opacity compared with left side, indicating swelling (A, white arrow)"
35434525
sparser
"Majority of cases show COL1A1–USP6 fusion and herein we have described an additional case with ANGPTL2 gene as a novel fusion partner with USP6 ."
32157177
sparser
"Pathology revealed the presence of muscular tissue mixed with fibroblastic/myofibroblastic proliferation and ossification areas consistent with myositis ossificans (Fig. 4); COL1A1-USP6 fusion transcript upon molecular investigation by RT-PCR method was found."
35434525
sparser
"COL1A1-USP6 fusion was predominant in ossifying lesions, including all FOs, MOs, ST-ABCs, and FOPDs with identified partner genes, and also present in non-ossifying head and neck NFs (HN-NFs) and C-FTSs in 2 cases each."
33000481
sparser
"We detected a MYH9-USP6 fusion in the two hip cases and a COL1A1-USP6 fusion in the shoulder case."
33404853
sparser
"Notably, we believed that FO may demonstrate more similar clinicopathologic and genetic manifestations with MO/FOPD and ST-ABC instead of nodular fasciitis for involving lower limbs most frequently and showing recurrent COL1A1::USP6 fusion."
36727055
ARF6 affects USP6
2 | 2 11
USP6 binds ARF6. 10 / 14
2 | 2 10
sparser
"It has been found that the TBC domain of TRE17 binds Arf6-GDP ( xref )."
17145964
sparser
"Via its TRE-2/Bub2/CDC16 (TBC) domain, TRE17 preferentially interacts with ARF6-GDP at tubular endosomes and facilitates its recycling to the PM ( xref )."
30042195
biogrid
No evidence text available
15509780
sparser
"Second, it was recently reported that the TBC domain of TRE17 binds to Arf6-GDP ( xref )."
17145964
sparser
"TRE17 binding to ARF6 increases its activation 50 ; although TRE17 does not itself have GEF activity towards ARF6, it may facilitate interaction of ARF6 with another GEF."
21587297
reach
"TRE17 binding to ARF6 increases its activation ; although TRE17 does not itself have GEF activity towards ARF6, it may facilitate interaction of ARF6 with another GEF."
21587297
sparser
"Based on our observation of internalization of CD147 prior to TRE17-mediated trafficking ( xref ) and the preferential binding of TRE17 to ARF6-GDP ( xref ), the former is more likely, as ARF6 undergoes GTP hydrolysis at SEs via interaction with the ACAP1/2 GAPs ( xref )."
30042195
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
sparser
"USP6 interacts with Arf6 through its N-terminus Tre2/Bub2/Csc16 (TBC) domain, and depletion of USP6 decreases Arf6 activity [19]."
| PMC
sparser
"If cargo such as MHC-I or CD98 was directed by infection into EEA1 membranes of a heterotypic SE, then it might be shielded or out of the reach of TRE17, which specifically associates with ARF6-GDP ( xref )."
30042195
USP6 binds ARF6 and EPI64. 1 / 1
| 1
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
Thraa affects USP6
| 6 8
USP6 binds thraa. 10 / 12
| 6 6
sparser
"Using specific antibody against TRα1 (designated as C4) in ChIP analysis, we found a strong binding of TRα1 to TRE2 in the bone marrow of euthyroid WT mice (bar 2 versus 1, Fig.  xref )."
29273766
reach
"Very low binding of NCOR1 to TRE2 bound TRalpha1 was detected in euthyroid WT mice."
29273766
reach
"However, significant binding of TRalpha1 to TRE2 was detected (compare bars 6 to 5, Fig."
29273766
reach
"As expected, a decreased binding of TRalpha1 to TRE2 was detected in the bone marrow of Thra1 PV/+ as well in Thra1 PV/+ Ncor1 DeltaID and DeltaID mice (bars 6 and 8 versus bar 2, Fig."
29273766
sparser
"Virtually no NCOR1 binding to TRE2-bound TRα1 was detected in Ncor1 ΔID / ΔID mice (bar 4 versus bar 2, Fig.  xref )."
29273766
reach
"In mice expressing NCOR1DeltaID, similar binding of TRalpha1 to TRE2 as in WT mice was found in the bone marrow of Ncor1 DeltaID and DeltaID mice (bar 4 versus bar 2)."
29273766
reach
"Using specific antibody against TRalpha1 (designated as C4) in ChIP analysis, we found a strong binding of TRalpha1 to TRE2 in the bone marrow of euthyroid WT mice (bar 2 versus 1, Fig."
29273766
sparser
"In mice expressing NCOR1ΔID, similar binding of TRα1 to TRE2 as in WT mice was found in the bone marrow of Ncor1 ΔID / ΔID mice (bar 4 versus bar 2)."
29273766
sparser
"However, significant binding of TRα1 to TRE2 was detected (compare bars 6 to 5, Fig.  xref )."
29273766
sparser
"Very low binding of NCOR1 to TRE2-bound TRα1 was detected in euthyroid WT mice."
29273766
USP6 binds thraa and TRα1PV. 2 / 2
| 2
sparser
"Using similar EMSA, we also found specific binding of TRα1 ( xref , lanes 5–9) and TRα1PV ( xref , lanes 11–15) to TRE2."
28910278
sparser
"Similar significantly higher binding of TRα1 (bar 3 versus bar 1, xref ) and TRα1PV (bar 6 versus bar 2, xref ) to TRE2 ( CCCACG GAGAT TCCTGT , in the region -3699 to -3325 bp) were also detected."
28910278
USP6 affects CALM1
| 14
USP6 binds CALM1. 10 / 14
| 14
sparser
"By 3 days post agro-infiltration (dpai), only the leaves co-infiltrated with pCAM-USP6 and pUS-US71GFP showed strong GFP fluorescence ( xref B)."
30558257
sparser
"Also, among various treatments, the leaves co-infiltrated with pUS-US71GFP and pCAM-USP6 showed the strongest green fluorescence ( xref B)."
30558257
sparser
"The three constructs were individually co-infiltrated with pCAM-USP6 into N. benthamiana leaves."
30558257
sparser
"Western blot assays showed a high amount of the GFP protein had accumulated in the leaves co-infiltrated with pCAM-USP6 and pUS-US71GFP."
30558257
sparser
"PCAM-USP6 was co-infiltrated with these three bicistronic constructs into N. benthamiana leaves."
30558257
sparser
"GFP fluorescence in the leaves co-infiltrated with pUS-US71GFP, pCAM-USP6, and pCAM-FveIF3g was much weaker than it was in the control leaves."
30558257
sparser
"In contrast, a strong GFP fluorescence was observed in the pCAM-USP6 and US71GFP co-expressed leaves."
30558257
sparser
"The results showed that strong GFP fluorescence was observed in the leaves co-infiltrated with pUS-US71GFP and pCAM-USP6, pUS-SY71GFP and pCAM-USP6, p35S-SY71GFP and pCAM-USP6, or pUS-Ca71GFP and pCAM-USP6 at 70 hpai."
30558257
sparser
"Leaves co-infiltrated with pCAM-USP6 and an empty vector (pCAM-2300) were used as a negative control."
30558257
sparser
"We then examined the effect of FveIF3g on P6 trans-activating activity by co-infiltrating N. benthamiana leaves with pUS-US71GFP, pCAM-USP6, and pCAM-FveIF3g or pUS-US71GFP, pCAM-USP6, and pCAM-2300 (control)."
30558257
USP6 affects JAK1
| 1 10 1
USP6 deubiquitinates JAK1.
| 1 4
USP6 deubiquitinates JAK1. 4 / 4
| 1 3
reach
"We previously showed that ubiquitin specific protease 6 (USP6) directly deubiquitinates and stabilizes Jak1, thereby inducing an IFN signature in ES cells."
33558334
reach
"To test whether USP6 can induce de-ubiquitination of Jak1 in vivo, HeLa cells were co-transfected with FLAG-Jak1, Myc-Ub, and HA-USP6 alleles."
27440725
reach
"We found that USP6 directly deubiquitinated Jak1, leading to its stabilization and activation of STAT3."
27440725
trips
"We found that USP6 directly deubiquitinated Jak1, leading to its stabilization and activation of STAT3."
27440725
Modified USP6 leads to the deubiquitination of JAK1. 1 / 1
| 1
reach
"Co-expression of USP6, but not USP6 (short), completely abolished ubiquitination of Jak1 in vivo (XREF_FIG)."
27440725
USP6 activates JAK1.
| 3
USP6 activates JAK1. 3 / 3
| 3
reach
"Jak1 in this clone was reduced to levels approximating those in control NIH3T3 cells (XREF_SUPPLEMENTARY), demonstrating that upregulation of Jak1 by USP6 is required for full activation of STAT3 by USP6."
27440725
reach
"Jak1 is upregulated by USP6 in a USP dependent manner."
27440725
reach
"Together, this group of experiments indicates that upregulation of Jak1 by USP6 is required not only for the production of autocrine and paracrine factors, but also for heightened STAT3 activation in response to them."
27440725
USP6 increases the amount of JAK1.
| 2
USP6 increases the amount of JAK1. 2 / 2
| 2
reach
"Our data support a model in which Jak1 levels are increased through de-ubiquitination by USP6, rendering cells hyper-sensitive to low levels of Jak1 agonists present in the microenvironment."
27440725
reach
"RT-qPCR revealed that Jak1 mRNA levels were not increased by USP6 (XREF_SUPPLEMENTARY)."
27440725
USP6 ubiquitinates JAK1.
| 1
Modified USP6 leads to the ubiquitination of JAK1. 1 / 1
| 1
reach
"Co-expression of USP6, but not USP6 (short), completely abolished ubiquitination of Jak1 in vivo (XREF_FIG)."
27440725
USP6 binds JAK1.
| 1
USP6 binds JAK1. 1 / 1
| 1
sparser
"USP6 associates with Jak1, and mediates its de-ubiquitination in vivo and in vitro ."
27440725
USP6 affects Neoplasms
| 10
USP6 activates Neoplasms. 10 / 10
| 10
reach
"Lu et al. [6] reported a novel CTNNB1-USP6 fusion in IVF, showing that IVF is a USP6-induced neoplasm and should be included in USP6-rearranged lesions.The most common clinical presentation is a painless, slowly growing mass."
33775935
reach
"We therefore propose a model for the pathogenesis of TRE17-driven tumors in which TRE17 increases CD147 at the cell surface by preventing its lysosomal degradation, which in turn enhances MMP synthesis and matrix degradation, thereby promoting tumor cell invasion."
35926707
reach
"The findings of this case suggest that these two tumors reside in the same biologic spectrum defined as USP6-induced tumors."
26198694
reach
"Although the molecular diagnosis was not performed, the findings of present case suggest that these two tumors reside in the same biologic spectrum defined as USP6-induced tumors."
26198694
reach
"USP6-induced neoplasms are almost universally benign and cured by local excision."
32583473
reach
"Intra-articular nodular fasciitis and aneurysmal bone cyst seem to belong to the same biological spectrum defined as USP6-induced tumors according to the report [8]."
31163331
reach
"[USP6 induced neoplasm and their clinicopathological and genetic advances]."
35249300
reach
"The purpose of this article is to review the imaging characteristics of the spectrum of USP6-driven neoplasms, highlight key features that allow distinction from malignant bone or soft tissue lesions, and discuss the role of imaging and molecular analysis in diagnosis."
35962835
reach
"Since the discovery of USP6 gene rearrangements in aneurysmal bone cysts nearly 20 years ago, we have come to recognize that there is a family of USP6-driven mesenchymal neoplasms with overlapping clinical, morphologic, and imaging features."
35962835
reach
"Recently, Oliveira and Chou suggested that aneurismal bone cysts and nodular fasciitis reside in the same biologic spectrum as USP6-induced tumors [9]."
26198694
USP6 is modified
3 | 7
USP6 is phosphorylated.
3 | 1
USP6 is phosphorylated on S1147. 1 / 1
1 |
hprd
No evidence text available
18669648
USP6 is phosphorylated on S1159. 1 / 1
1 |
hprd
No evidence text available
18669648
USP6 is phosphorylated. 1 / 1
| 1
sparser
"GRK induces phosphorylation of the receptor thereby leading to the formation of phosphorylated receptor HRP1 ( xref )."
22735336
USP6 is phosphorylated on S1169. 1 / 1
1 |
hprd
No evidence text available
18669648
USP6 is methylated.
| 3
USP6 is methylated. 3 / 3
| 3
sparser
"In contrast with observation from mammalian systems, arginine methylation of the budding yeast S. cerevisiae hnRNP-like proteins Npl3, Hrp1, and Nab2 promotes their proper nuclear export [ xref , xref ]."
22091396
sparser
"Although methylation of hnRNPA1 had a slight effect on nonspecific binding to homopolymeric RNA (Rajpurohit et al., 1994) , methylation of yeast hnRNP Hrp1 did not affect its affinity for a specific [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11461695
sparser
"However, Rmt1 is known to bind and/or methylate a number of proteins that process and export mRNA; methylation of Rmt1 target proteins Npl3, Hrp1, and Nab2 promotes their dissociation from nuclear factors and facilitates their export from the nucleus. xref – xref This is consistent with RPS2’s known functions of processing and exporting 20S rRNA, a precursor for 40s ribosomal subunits. xref , xref Our observation that RPS2 R10 dimethylation increases tenfold in stationary phase suggests that the cell may be facilitating export of RPS2 from the nucleus."
24486316
USP6 is sumoylated.
| 2
USP6 is sumoylated. 2 / 2
| 2
sparser
"Absent SUMOylation of Hrp1 results in improper mRNP assembly of a subset of acidic stress-induced transcripts that escape degradation [ xref ]."
32932892
sparser
"While blocking Hrp1 sumoylation does not appear to affect mRNA export, it leads to improper mRNP assembly of a subset of stress-induced transcripts that are normally degraded by the exosome."
28197904
USP6 is ubiquitinated.
| 1
USP6 is ubiquitinated. 1 / 1
| 1
sparser
"Ubiquitination of USP6 in the Context of Protein–Protein Interaction."
21480003
USP6 affects RELA
| 9
USP6 phosphorylates RELA.
| 8
USP6 phosphorylates RELA on S536. 4 / 4
| 4
sparser
"TRE17 stimulates phosphorylation of p65 at serine 536, a modification that has been associated with enhanced transcriptional activity and nuclear retention."
22081069
sparser
"TRE17 stimulates phosphorylation of p65 at serine 536, a modification that has been associated with enhanced transcriptional activity and nuclear retention."
22081069
sparser
"TRE17 induces phosphorylation of p65 on serine 536 through IKKα and IKKβ."
22081069
sparser
"TRE17 induces phosphorylation of p65 on serine 536 through IKKα and IKKβ."
22081069
USP6 phosphorylates RELA. 4 / 4
| 4
sparser
"As seen in xref , TRE17-induced phosphorylation of p65 was significantly attenuated in cells depleted of each of the IKK subunits."
22081069
sparser
"As seen in xref , TRE17-induced phosphorylation of p65 was significantly attenuated in cells depleted of each of the IKK subunits."
22081069
sparser
"TRE17(long) induced phosphorylation of S536-p65 in both the MC3T3 stable cell lines and transiently transfected HeLa cells ( xref )."
22081069
sparser
"TRE17(long) induced phosphorylation of S536-p65 in both the MC3T3 stable cell lines and transiently transfected HeLa cells ( xref )."
22081069
USP6 binds RELA.
| 1
IKK_complex binds USP6 and RELA. 1 / 1
| 1
sparser
"TRE17 associates with IKK and promotes its activation, leading to phosphorylation of p65 on S536."
22081069
USP6 affects CTNNB1
| 1 2 6
USP6 binds CTNNB1.
| 5
USP6 binds CTNNB1. 5 / 5
| 5
sparser
"The CTNNB1::USP6 gene fusion has not been previously reported in intraneural nodular fasciitis, although it has been reported in three entities including aneurysmal bone cyst, nodular fasciitis, and intravascular fasciitis."
35175167
sparser
"Intraneural Nodular Fasciitis of the Femoral Nerve with A Unique CTNNB1::USP6 Gene Fusion: Apropos of a Case and Review of Literature."
35175167
sparser
"Lu et al. [ xref ] reported a novel CTNNB1-USP6 fusion in IVF, showing that IVF is a USP6 -induced neoplasm and should be included in USP6 -rearranged lesions."
33775935
sparser
"Next-generation sequencing uncovered the presence of a CTNNB1::USP6 gene fusion involving CTNNB1 gene in exon 1 at the genomic position chr3:41241161 and the USP6 gene in exon 1 at the genomic position chr17:5033231."
35175167
sparser
"Correction to: Novel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing."
32472194
USP6 activates CTNNB1.
| 1 1 1
USP6 activates CTNNB1. 3 / 3
| 1 1 1
sparser
"In these models, activation of STAT3, NF-κB, and β-catenin by USP6 was essential for tumorigenesis, as genetic or pharmacologic inhibition of these pathways significantly attenuated xenograft growth ( xref , xref , xref )."
33558334
eidos
"In these models , activation of STAT3 , NF-kappaB , and beta-catenin by USP6 was essential for tumorigenesis , as genetic or pharmacologic inhibition of these pathways significantly attenuated xenograft growth ( 16 , 23 , 24 ) ."
33558334
reach
"Contrary to RNF43, ubiquitin specific protease 6 (USP6) is a deubiquitylase; ectopic expression of USP6 increases cell surface abundance of Fzds and Lrp6 and activates beta-catenin pathway in tumor cells XREF_BIBR."
32998794
USP6 decreases the amount of CTNNB1.
| 1
USP6 decreases the amount of CTNNB1. 1 / 1
| 1
reach
"USP6 was a target of miR-130a and the overexpression of miR-130a or inhibition of USP6 in UM MUM-2B and MUM-2C cell lines inhibited the expression of Wnt, β-catenin, and EGFR, and activated SMAD4 expression, while reducing UM cell migration and invasion abilities in vitro."
34522027
USP6 affects Wnt
| 7
USP6 activates Wnt.
| 6
USP6 activates Wnt. 6 / 6
| 6
reach
"Additionally, the deubiquitinating enzymes UBPY and USP6 may promote the recycling of endocytosed FZD back to the surface and restore Wnt signaling."
29632210
reach
"Interestingly, the Wnt antagonist Dickkopf-1 (DKK1) or LRP5/6 siRNA blocked USP6 induced Wnt signalling, suggesting that a Wnt-ligand receptor complex is required for USP6 function."
34414184
reach
"A genomewide siRNA screen revealed that deubiquitinase USP6 overexpression could activate Wnt signaling by inhibition of Fzd7 endocytosis and its subsequent targeting for degradation [XREF_BIBR]."
28913633
reach
"USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds."
27162353
reach
"USP6 enhances Wnt signaling by deubiquitylating Fzds, thereby increasing their cell-surface abundance."
27162353
reach
"In a separate whole-genome siRNA screen, USP6 was found to activate Wnt signalling by deubiquitylating Frizzled receptors and increasing their plasma membrane expression 28."
28064438
USP6 decreases the amount of Wnt.
| 1
USP6 decreases the amount of Wnt. 1 / 1
| 1
reach
"USP6 was a target of miR-130a and the overexpression of miR-130a or inhibition of USP6 in UM MUM-2B and MUM-2C cell lines inhibited the expression of Wnt, β-catenin, and EGFR, and activated SMAD4 expression, while reducing UM cell migration and invasion abilities in vitro."
34522027
USP6 affects TR
| 6
USP6 binds TR. 6 / 6
| 6
sparser
"As indicated above, given the limitation of the ChIP assay, it is possible that the weak TR ChIP signal at TRE1 was a result of TR binding at the TRE2 and TRE2 is the only TRE bound by TR during metamorphosis in the intestine and tail."
22800560
sparser
"In any case, our findings together indicate that Dot1L gene is a direct T3 target gene that is regulated via binding of the TR predominantly to TRE2."
22800560
sparser
"TR is bound to the Dot1L TRE2 in both intestine and tail of premetamorphic tadpoles."
22800560
sparser
"That is, TR also bound predominantly to the TRE2 in the tail of premetamorphic tadpoles treated with or without T3 for 2 days."
22800560
sparser
"This could occur if the TRE1 region was present in some large fragments of DNA immunoprecipitated due to TR binding to the TRE2."
22800560
sparser
"On the other hand, as the DNA generated by sonication during the ChIP assay could be as long as 1 kb (typically averaging around 500 bp), we could not rule out the possibility that the signal observed at TRE1 was due to TR binding at TRE2."
22800560
USP6 affects MYL2
3 1 | 1 1
USP6 binds MYL2. 6 / 6
3 1 | 1 1
biogrid
No evidence text available
16555005
biogrid
No evidence text available
16555005
biogrid
No evidence text available
16555005
hprd
No evidence text available
16555005
sparser
"Although the biological significance of these interactions remains unknown, the observation that USP6 appeared to cause redistribution of Myl2 and LOC91526 to the cell membrane lead to the proposal that the binding of USP6 to Myl2 participates in RhoGTPase signaling [ xref , xref ]."
18687060
reach
"Although the biological significance of these interactions remains unknown, the observation that USP6 appeared to cause redistribution of Myl2 and LOC91526 to the cell membrane lead to the proposal that the binding of USP6 to Myl2 participates in RhoGTPase signaling [XREF_BIBR, XREF_BIBR]."
18687060
USP6 affects MMP9
1 1 | 3 1
USP6 increases the amount of MMP9.
1 | 3
USP6 increases the amount of MMP9. 3 / 3
| 3
reach
"XREF_BIBR, XREF_BIBR USP6 was shown to induce transcription of MMP9 through the activation of nuclear factor-kappaB (NF-kappaB) in a USP dependent manner."
32904569
reach
"Especially, USP6 induces the transcription of MMP9 through activation of NF-kappaB."
32904569
reach
"XREF_BIBR USP6 is sufficient to induce the expression of MMP9 and MMP10."
32904569
Transcriptionally active USP6 increases the amount of MMP9. 1 / 1
1 |
signor
"In this study we show that tre17 is sufficient to induce expression of mmp-9 and mmp-10, in a manner requiring its usp activity, but not its ability to bind arf6. Tre17 induces transcription of mmp-9 through activation of nuclear factor-kappab (nf-kappab), mediated in part by the gtpase rhoa and its effector kinase, rock."
20418905
USP6 deubiquitinates MMP9.
1 |
USP6 deubiquitinates MMP9. 1 / 1
1 |
USP6 activates MMP9.
| 1
USP6 activates MMP9. 1 / 1
| 1
sparser
"Loss of the NFκB-binding site abrogated activation of the MMP-9 promoter by TRE17(long) in hFOB1.19 and HeLa ( xref ), indicating that NFκB is the key mediator of TRE17-induced MMP-9 gene transcription."
20418905
USP6 affects Cell Survival
| 2 4
USP6 activates Cell Survival.
| 2 3
USP6 activates Cell Survival. 5 / 5
| 2 3
eidos
"In contrast , absence of USP6 caused a significant decrease in cell survival versus NT control siRNA cells after high-LET alpha - particle irradiation ( Fig. 2B , 2D ) and high-LET protons ( Fig. 2F , 2H ) ."
30851349
reach
"Jak1 is required for STAT3 activation by USP6, and both are required for USP6 mediated cell survival and tumorigenesis."
27440725
reach
"Depletion of USP6 decreased cell survival specifically after high-LET alpha-particles and protons, but not low-LET protons or x-rays."
30851349
reach
"Using high-LET protons (Fig. 1C; Fig. E1B, available online at https://doi.org/10.1016/j.ijrobp.2019.02.053), depletion of USP6 (plus CYLD, USP7, USP31, and USP9X) also reduced cell survival by >40%."
30851349
eidos
"This approach identified ubiquitin specific protease 6 ( USP6 ) , which modulates cell survival after high-LET IR by promoting efficient repair of CDD sites ."
30851349
USP6 inhibits Cell Survival.
| 1
USP6 inhibits Cell Survival. 1 / 1
| 1
reach
"Depletion of USP6 decreased cell survival specifically following high-LET alpha-particles and protons, but not by low-LET protons or x-rays."
30851349
TR affects USP6
| 6
USP6 binds TR. 6 / 6
| 6
sparser
"As indicated above, given the limitation of the ChIP assay, it is possible that the weak TR ChIP signal at TRE1 was a result of TR binding at the TRE2 and TRE2 is the only TRE bound by TR during metamorphosis in the intestine and tail."
22800560
sparser
"In any case, our findings together indicate that Dot1L gene is a direct T3 target gene that is regulated via binding of the TR predominantly to TRE2."
22800560
sparser
"TR is bound to the Dot1L TRE2 in both intestine and tail of premetamorphic tadpoles."
22800560
sparser
"That is, TR also bound predominantly to the TRE2 in the tail of premetamorphic tadpoles treated with or without T3 for 2 days."
22800560
sparser
"This could occur if the TRE1 region was present in some large fragments of DNA immunoprecipitated due to TR binding to the TRE2."
22800560
sparser
"On the other hand, as the DNA generated by sonication during the ChIP assay could be as long as 1 kb (typically averaging around 500 bp), we could not rule out the possibility that the signal observed at TRE1 was due to TR binding at TRE2."
22800560
MYL2 affects USP6
3 1 | 1 1
USP6 binds MYL2. 6 / 6
3 1 | 1 1
biogrid
No evidence text available
16555005
biogrid
No evidence text available
16555005
biogrid
No evidence text available
16555005
hprd
No evidence text available
16555005
sparser
"Although the biological significance of these interactions remains unknown, the observation that USP6 appeared to cause redistribution of Myl2 and LOC91526 to the cell membrane lead to the proposal that the binding of USP6 to Myl2 participates in RhoGTPase signaling [ xref , xref ]."
18687060
reach
"Although the biological significance of these interactions remains unknown, the observation that USP6 appeared to cause redistribution of Myl2 and LOC91526 to the cell membrane lead to the proposal that the binding of USP6 to Myl2 participates in RhoGTPase signaling [XREF_BIBR, XREF_BIBR]."
18687060
USP6 activates transcription, DNA-templated. 3 / 3
| 2 1
reach
"Thus, the intronic TRE2 can mediate transcription regulation by liganded TR/RXR in vivo."
31585895
sparser
"TRα1/T3 via interacting with TRE1 mediated suppression of the transcription whereas TRα1/T3 via interacting with TRE2 activated transcription."
28910278
reach
"TRalpha1/T3 via interacting with TRE1 mediated suppression of the transcription whereas TRalpha1/T3 via interacting with TRE2 activated transcription."
28910278
reach
"Loss of either Hrp1 or Hrp3 leads to increased cryptic transcription, similar to that observed upon loss of Isw1 and Chd1 in budding yeast [XREF_BIBR - XREF_BIBR]."
23870137
reach
"Hrp1 forms the B component of the CFI polyadenylation factor and, when overexpressed, increases recognition of a weakened polyadenylation site and suppresses the defective transcription termination."
19099192
USP6 affects THR
| 3 2
THR binds USP6. 5 / 5
| 3 2
sparser
"TRE2 in vivo , we carried out ChIP assay on intestinal Analysis of the ChIP DNA by using a primer pair chromatin extracted from premetamorphic tadpoles flanking TRE2 showed that TR was bound to TRE2 in premetamorphic tadpole intestine and T3 treatment enhanced TR binding to TRE2 ( xref )."
31585895
reach
"TRE2 in vivo, we carried out ChIP assay on intestinal Analysis of the ChIP DNA by using a primer pair chromatin extracted from premetamorphic tadpoles flanking TRE2 showed that TR was bound to TRE2 in premetamorphic tadpole intestine and T3 treatment enhanced TR binding to TRE2 (Figure 5)."
31585895
reach
"To determine if the strong binding of TRE2 to the TR/RXR heterodimer was sequence-specific, we mutated the putative TRE2 at the positions known to be important for binding to TR/RXR heterodimer (Figure 3B) and determined the effect in the mobility shift assay."
31585895
sparser
"More importantly, TRE2 is bound by TR in the tadpole intestine and T3 treatment of premetamorphic tadpoles leads to increased level of the activation histone mark H3K79 methylation and recruitment of RNA polymerase II to the TRE2 in the tadpole intestine."
31585895
reach
"More importantly, TRE2 is bound by TR in the tadpole intestine and T3 treatment of premetamorphic tadpoles leads to increased level of the activation histone mark H3K79 methylation and recruitment of RNA polymerase II to the TRE2 in the tadpole intestine."
31585895
USP6 activates Neoplasm Invasiveness.
| 4
USP6 activates Neoplasm Invasiveness. 4 / 4
| 4
reach
"Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of glycoprotein CD147 intracellular trafficking."
35926707
reach
"As an independent prognostic factor, USP6 promotes the invasion and metastasis of colon cancer."
30297112
reach
"Furthermore, cell function assay demonstrated that USP6 could promote colon cancer cells ' invasion invitro and liver metastasis invivo."
30297112
reach
"Furthermore, we demonstrate that inhibition of CD147 by a specific inhibitor alleviated the TRE17-promoted tumor cell invasion."
35926707
USP6 inhibits Neoplasm Invasiveness.
| 1
USP6 inhibits Neoplasm Invasiveness. 1 / 1
| 1
reach
"We therefore propose a model for the pathogenesis of TRE17-driven tumors in which TRE17 increases CD147 at the cell surface by preventing its lysosomal degradation, which in turn enhances MMP synthesis and matrix degradation, thereby promoting tumor cell invasion."
35926707
USP6 affects Interferon
| 3 2
USP6 activates Interferon.
| 3
USP6 activates Interferon. 3 / 3
| 3
reach
"USP6 synergistically enhanced chemokine production in response to exogenous IFN by inducing surface upregulation of IFNAR1 and IFNGR1."
33558334
reach
"Single gene complementation of two Cluster V mutants, Tn : : Rv0712 and Tn : : hrp1 (hypoxic response protein 1, Rv2626c), restored the type I IFN response (XREF_FIG), suggesting that each of these genes is required for induction of type I IFNs."
28505176
reach
"Not only does USP6 independently induce activation of the IFN signaling mediators JAK1 and STAT1, but it also renders ES cells exquisitely responsive to exogenous IFNs, potentiating activation of STAT1 and STAT3."
30131449
USP6 binds Interferon.
| 2
Interferon binds USP6. 2 / 2
| 2
sparser
"In addition, USP6 expression was associated with an IFN response in germ cell tumors."
30131449
sparser
"We next explored whether USP6 was associated with an IFN response in other tumor types."
30131449
USP6 affects GLS
| 1 4
USP6 binds GLS.
| 3
USP6 binds GLS. 3 / 3
| 3
sparser
"Together, these findings indicated that USP6 interacted with GLS1 and inhibited GLS1 ubiquitination."
35091542
sparser
"USP6 interacted with GLS1 and inhibited GLS1 ubiquitination in CML cells."
35091542
sparser
"Further studies showed that USP6 interacted with GLS1 and inhibited GLS1 ubiquitination in CML cells."
35091542
USP6 ubiquitinates GLS.
| 1 1
USP6 leads to the ubiquitination of GLS. 2 / 2
| 1 1
reach
"Overexpressing USP6 significantly increased GLS1 ubiquitination to decrease GLS protein."
35091542
sparser
"Overexpressing USP6 significantly increased GLS1 ubiquitination to decrease GLS protein."
35091542
THR affects USP6
| 3 2
THR binds USP6. 5 / 5
| 3 2
sparser
"TRE2 in vivo , we carried out ChIP assay on intestinal Analysis of the ChIP DNA by using a primer pair chromatin extracted from premetamorphic tadpoles flanking TRE2 showed that TR was bound to TRE2 in premetamorphic tadpole intestine and T3 treatment enhanced TR binding to TRE2 ( xref )."
31585895
reach
"TRE2 in vivo, we carried out ChIP assay on intestinal Analysis of the ChIP DNA by using a primer pair chromatin extracted from premetamorphic tadpoles flanking TRE2 showed that TR was bound to TRE2 in premetamorphic tadpole intestine and T3 treatment enhanced TR binding to TRE2 (Figure 5)."
31585895
reach
"To determine if the strong binding of TRE2 to the TR/RXR heterodimer was sequence-specific, we mutated the putative TRE2 at the positions known to be important for binding to TR/RXR heterodimer (Figure 3B) and determined the effect in the mobility shift assay."
31585895
sparser
"More importantly, TRE2 is bound by TR in the tadpole intestine and T3 treatment of premetamorphic tadpoles leads to increased level of the activation histone mark H3K79 methylation and recruitment of RNA polymerase II to the TRE2 in the tadpole intestine."
31585895
reach
"More importantly, TRE2 is bound by TR in the tadpole intestine and T3 treatment of premetamorphic tadpoles leads to increased level of the activation histone mark H3K79 methylation and recruitment of RNA polymerase II to the TRE2 in the tadpole intestine."
31585895
CTNNB1 affects USP6
| 5
USP6 binds CTNNB1. 5 / 5
| 5
sparser
"The CTNNB1::USP6 gene fusion has not been previously reported in intraneural nodular fasciitis, although it has been reported in three entities including aneurysmal bone cyst, nodular fasciitis, and intravascular fasciitis."
35175167
sparser
"Intraneural Nodular Fasciitis of the Femoral Nerve with A Unique CTNNB1::USP6 Gene Fusion: Apropos of a Case and Review of Literature."
35175167
sparser
"Lu et al. [ xref ] reported a novel CTNNB1-USP6 fusion in IVF, showing that IVF is a USP6 -induced neoplasm and should be included in USP6 -rearranged lesions."
33775935
sparser
"Next-generation sequencing uncovered the presence of a CTNNB1::USP6 gene fusion involving CTNNB1 gene in exon 1 at the genomic position chr3:41241161 and the USP6 gene in exon 1 at the genomic position chr17:5033231."
35175167
sparser
"Correction to: Novel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing."
32472194
USP6 affects TR/RXR
| 4
USP6 binds TR/RXR.
| 3
USP6 binds TR/RXR. 3 / 3
| 3
reach
"Thus, TR/RXR likely binds to TRE2 in the tadpole intestine and activates Sox3 gene transcription during metamorphosis when T3 is present."
27567710
reach
"Taken together, these results suggest that TR/RXR binds independently to both TRE1 and TRE2."
16899449
reach
"In particular, one of them, TRE2 binds to TR/RXR heterodimers strongly in vitro and is required to mediate the activation of the Sox3 promoter by TR/RXR in the presence of T3 in reconstituted frog oocyte transcription system (XREF_FIG)."
27567710
USP6 activates TR/RXR.
| 1
USP6 activates TR/RXR. 1 / 1
| 1
reach
"The intronic TRE2 mediates TR/RXR regulation of MBD3 promoter."
31585895
USP6 affects NMDAR
| 1 3
USP6 binds NMDAR.
| 3
USP6 binds NMDAR. 2 / 2
| 2
sparser
"Together, these results indicate that USP6 can interact with NMDAR subunits and promotes their stabilization by reducing NMDAR ubiquitination."
31841517
sparser
"After establishing a role for USP6 in modulating NMDAR ubiquitination and expression, we determined whether USP6 interacts with NMDAR subunits."
31841517
USP6 binds HMBS, NMDAR, and NMDAR. 1 / 1
| 1
sparser
"USP6 interacts with NMDARs to attenuate UPS-mediated NMDAR turnover."
31841517
USP6 activates NMDAR.
| 1
USP6 activates NMDAR. 1 / 1
| 1
reach
"Together, these results indicate that USP6 enhances NMDAR stability to promote synaptic function and cognition."
31841517
USP6 affects JUN
3 1 |
USP6 binds JUN.
3 |
USP6 binds JUN. 3 / 3
3 |
biogrid
No evidence text available
29061731
biogrid
No evidence text available
29061731
biogrid
No evidence text available
29061731
USP6 deubiquitinates JUN.
1 |
USP6 deubiquitinates JUN. 1 / 1
1 |
ubibrowser
"Based on our data, USP6 is an enzyme that deubiquitinates c-Jun and regulates its downstream cellular functions."
29061731
USP6 affects Chemokine
| 4
USP6 activates Chemokine. 4 / 4
| 4
eidos
"Among the genes with the greatest synergistic induction were ligands for CXCR3 and CCR5 : USP6 or IFNalpha individually led to modest increases in levels of these chemokines , whereas expression was increased 2-4 orders of magnitude in USP6-expressing cells treated with IFNalpha ( Supplemental Figure 3B ) ."
33558334
eidos
"We tested a range of IFNgamma doses and found that USP6 amplified chemokine expression at all doses : at a low dose of 0.5 ng / ml , IFNgamma had no effect on control RD-ES cells , but induced a 10,000 - fold increase in CXCL10 and 100-fold increase in CCL5 expression in USP6 / RD-ES ( Figure 1B ) ."
33558334
eidos
"USP6 synergistically enhances chemokine induction upon IFN treatment in vitro We previously reported that USP6 not only induces an IFN gene signature by itself , but that it also magnifies the response to exogenous Type I and II IFNs ( 17 ) ."
33558334
eidos
"USP6 synergistically enhanced chemokine production in response to exogenous IFN by inducing surface upregulation of IFNAR1 and IFNGR1 ."
33558334
USP6 affects CALM
| 1 3
CALM binds USP6. 4 / 4
| 1 3
sparser
"Calmodulin directly interacts with USP6 in a Ca 2+ -dependent pattern (i.e. this binding is regulated by physiological alteration in the level of Ca 2+ in vitro as well as in vivo )."
28659380
reach
"Calmodulin directly interacts with USP6 in a Ca 2+ -dependent pattern (i.e. this binding is regulated by physiological alteration in the level of Ca 2+ in vitro as well as in vivo)."
28659380
sparser
"CaM bound directly to TRE17 in a Ca2+-dependent manner both in vitro and in vivo."
16127172
sparser
"Point mutations within these motifs significantly reduced the interaction of TRE17 with CaM."
16127172
USP6 affects BSG
| 3 1
USP6 activates BSG.
| 2
USP6 activates BSG. 2 / 2
| 2
reach
"On the other hand, we show knockdown of TRE17 decreases cell surface CD147, which is coupled with reduced production of matrix metalloproteinases (MMPs), the enzymes responsible for extracellular matrix degradation."
35926707
reach
"We therefore propose a model for the pathogenesis of TRE17-driven tumors in which TRE17 increases CD147 at the cell surface by preventing its lysosomal degradation, which in turn enhances MMP synthesis and matrix degradation, thereby promoting tumor cell invasion."
35926707
USP6 increases the amount of BSG.
| 1
USP6 increases the amount of BSG. 1 / 1
| 1
reach
"Here, we show that increased expression of TRE17 enhances invasiveness of the human sarcoma cell line HT-1080 by elevating the cell surface levels of the membrane glycoprotein CD147, which plays a central role in tumor progression."
35926707
USP6 binds BSG.
| 1
BSG binds USP6, CD59, and EEA1. 1 / 1
| 1
sparser
"In infected cells overexpressing TRE17, both CD59 and CD147 were predominantly associated with EEA1 − /ARF6 + /TRE17 + membranes in HCMV infection [ xref and xref , (+)TRE17 panels]."
30042195
USP6 affects ANKRD44
3 1 |
USP6 binds ANKRD44. 4 / 4
3 1 |
hprd
No evidence text available
16555005
biogrid
No evidence text available
16555005
biogrid
No evidence text available
16555005
biogrid
No evidence text available
16555005
USP6 affects ANGPTL2
| 4
USP6 binds ANGPTL2. 4 / 4
| 4
sparser
"RNASeq further detected COL1A1-USP6 fusion in six cases and a novel ANGPTL2-USP6 fusion in one case."
32157177
sparser
"Case 3 was unique for the lack of zonal growth pattern and a novel ANGPTL2-USP6 fusion."
32157177
sparser
"A novel fusion ANGPTL2-USP6 is associated with distinct clinical and pathological presentation."
32157177
sparser
"Case 3 had a novel ANGPTL2-USP6 fusion."
32157177
PRMT2 affects USP6
| 2 2
PRMT2 methylates USP6. 4 / 4
| 2 2
reach
"Taken together, these results suggest that methylation of Hrp1 and Nab2 by Hmt1 is required for interaction with the Ccr4 and Not complex."
21464899
sparser
"Hmt1 methylates Yra1 and Hrp1, two mRNA-binding proteins important for mRNA processing and export."
15314027
reach
"Hmt1 methylates Yra1 and Hrp1, two mRNA binding proteins important for mRNA processing and export."
15314027
sparser
"Taken together, these results suggest that methylation of Hrp1 and Nab2 by Hmt1 is required for interaction with the Ccr4-Not complex."
21464899
CALM affects USP6
| 1 3
CALM binds USP6. 4 / 4
| 1 3
sparser
"Calmodulin directly interacts with USP6 in a Ca 2+ -dependent pattern (i.e. this binding is regulated by physiological alteration in the level of Ca 2+ in vitro as well as in vivo )."
28659380
reach
"Calmodulin directly interacts with USP6 in a Ca 2+ -dependent pattern (i.e. this binding is regulated by physiological alteration in the level of Ca 2+ in vitro as well as in vivo)."
28659380
sparser
"CaM bound directly to TRE17 in a Ca2+-dependent manner both in vitro and in vivo."
16127172
sparser
"Point mutations within these motifs significantly reduced the interaction of TRE17 with CaM."
16127172
ANKRD44 affects USP6
3 1 |
USP6 binds ANKRD44. 4 / 4
3 1 |
hprd
No evidence text available
16555005
biogrid
No evidence text available
16555005
biogrid
No evidence text available
16555005
biogrid
No evidence text available
16555005
ANGPTL2 affects USP6
| 4
USP6 binds ANGPTL2. 4 / 4
| 4
sparser
"RNASeq further detected COL1A1-USP6 fusion in six cases and a novel ANGPTL2-USP6 fusion in one case."
32157177
sparser
"Case 3 was unique for the lack of zonal growth pattern and a novel ANGPTL2-USP6 fusion."
32157177
sparser
"A novel fusion ANGPTL2-USP6 is associated with distinct clinical and pathological presentation."
32157177
sparser
"Case 3 had a novel ANGPTL2-USP6 fusion."
32157177
USP6 affects PNA1
| 3
USP6 binds PNA1. 3 / 3
| 3
reach
"In our experimental system, binding of RNA and PNA1 to HRP1 resulted in similar changes in the CD signal, decrease at 240-260 nm and increase at 280-290 nm, which were fully consistent with the CD spectra previously observed for the triple helical binding of cytosine rich PNA to double stranded DNA."
20527745
reach
"Next, we tested the binding of PNA1 to HRP1 at physiological pH (XREF_TABLE, entry 6)."
20527745
reach
"Finally, the CD spectra of RNA and PNA1 bound to HRP1 were fully consistent with previous results on PNA-DNA triple helices."
20527745
USP6 affects PAFAH1B1
| 3
USP6 binds PAFAH1B1. 3 / 3
| 3
sparser
"Subsequent next-generation sequencing-based technology revealed a novel PAFAH1B1-USP6 fusion gene as well as unusual fusion point on USP6 (exon 9)."
33161462
sparser
"Additionally, PAFAH1B1-USP6 fusion has never been described in NF."
33161462
sparser
"Atypical nodular fasciitis with a novel PAFAH1B1-USP6 fusion in a 22-month-old boy."
33161462
USP6 affects MBD3
| 3
USP6 increases the amount of MBD3.
| 2
USP6 increases the amount of MBD3. 2 / 2
| 2
reach
"Thus, the intronic TRE2 in the MBD3 gene is bound by TR in premetamorphic tadpole intestine and likely mediate the activation of MBD3 expression by T3 via histone modification during metamorphosis."
31585895
reach
"To determine if the intronic TRE2 can mediate the transcriptional regulation of Xenopus tropicalis MBD3 expression by T3 in vivo, we cloned a genomic MBD3 fragment encompassing 1 kb upstream of the predicted transcription start site, exon 1 (276bp) and a part of intron 1 that included the putative TRE2 (265bp), upstream of the coding region of firefly luciferase gene in a reporter construct (Figure 4A)."
31585895
USP6 activates MBD3.
| 1
USP6 activates MBD3. 1 / 1
| 1
reach
"The intronic TRE2 mediates TR/RXR regulation of MBD3 promoter."
31585895
USP6 affects KRAS
| 3
USP6 binds KRAS and EGFP. 2 / 2
| 2
sparser
"We further generated ankrd45 mutants carrying a doxycycline-inducible transgenic line, Tg ( fabp10:rtTA2s-M2 ;TRE2:EGFP-kras G12V ), which contained a liver-specific double transgene to induce the expression of EGFP-Kras G12V specifically in the liver [ xref , xref ]."
31208154
sparser
"In this study, transgenic zebrafish Tg(fabp10:rtTA2s-M2; TRE2:EGFP-KRAS G12V ), a hepatocellular carcinoma (HCC) model that can cause liver tumorigenesis by doxycycline (DOX) induction, was used to investigate the effect of PFOS exposure in HCC progression."
33675800
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
USP6 affects GRIN1
1 | 2
USP6 inhibits GRIN1.
| 1
USP6 inhibits GRIN1. 1 / 1
| 1
reach
"USP6 positively modulates GluN1 expression in transfected cells, and USP6 down-regulation impedes focal GluN1 distribution at postsynaptic densities and impairs synaptic function in neurons derived from human embryonic stem cells."
31841517
USP6 increases the amount of GRIN1.
| 1
USP6 increases the amount of GRIN1. 1 / 1
| 1
reach
"USP6 positively modulates GluN1 expression in transfected cells, and USP6 down-regulation impedes focal GluN1 distribution at postsynaptic densities and impairs synaptic function in neurons derived from human embryonic stem cells."
31841517
USP6 deubiquitinates GRIN1.
1 |
USP6 deubiquitinates GRIN1. 1 / 1
1 |
ubibrowser
"We also found that USP6 binds to and deubiquitinates NMDARs, thereby enhancing NMDAR stability."
31841517
USP6 affects FOS1
| 3
USP6 binds FOS1. 3 / 3
| 3
sparser
"When MEK-1 and KGB-1 were co-expressed with T7-FOS-1 in COS-7 cells, the association of FOS-1 with the optimal TRE2 probe was decreased ( xref , lanes 1–3)."
23437011
sparser
"To examine whether FOS-1 binds directly to the kreg-1 promoter via TRE2, we conducted chromatin immunoprecipitation (ChIP) assays."
23437011
sparser
"In this model, FOS-1 forms homodimers and binds to the TRE2 motif in the kreg-1 promoter."
23437011
USP6 affects COL6A2
| 3
USP6 binds COL6A2. 3 / 3
| 3
sparser
"For example, the COL6A2-USP6 fusion that was initially missed by RNA-seq because of low fusion fragments per million (< 0.1) combined with the absence of COL6A2 or USP6 on the inclusion list. (4) Finally, RNA-seq has a longer turnaround time of 7-21 days compared with more targeted approaches."
35085008
sparser
"In case PMABM000BJK/27, a COL6A2-USP6 fusion was identified in routine diagnostics by targeted RNA-seq (Archer FusionPlex Sarcoma, Invitae, Boulder, CO) but not identified using RNA-seq."
35085008
sparser
"Nodular Fasciitis With Malignant Morphology and a COL6A2-USP6 Fusion: A Case Report (of a 10-Year-old Boy)."
33625261
USP6 affects CALM2
3 |
USP6 binds CALM2. 3 / 3
3 |
biogrid
No evidence text available
16127172
biogrid
No evidence text available
16127172
biogrid
No evidence text available
16127172
USP6 affects AHNAK
| 3
USP6 binds AHNAK. 3 / 3
| 3
sparser
"Herein, we report a case of a 29-year-old female with a synchronous polyostotic solid variant of ABC involving her T7-T11 posterior elements of her thoracic vertebrae with a novel AHNAK::USP6 fusion, detected by next-generation sequencing (NGS)."
35717456
sparser
"This case is distinguished by its synchronous polyostotic presentation, solid rather than classic ABC morphology and novel AHNAK::USP6 fusion, which has not been previously reported in ABC or in any mesenchymal bone tumor."
35717456
sparser
"Synchronous polyostotic solid variant of aneurysmal bone cyst involving thoracic vertebrae and harboring a novel AHNAK::USP6 gene fusion."
35717456
TR/RXR affects USP6
| 3
USP6 binds TR/RXR. 3 / 3
| 3
reach
"Thus, TR/RXR likely binds to TRE2 in the tadpole intestine and activates Sox3 gene transcription during metamorphosis when T3 is present."
27567710
reach
"Taken together, these results suggest that TR/RXR binds independently to both TRE1 and TRE2."
16899449
reach
"In particular, one of them, TRE2 binds to TR/RXR heterodimers strongly in vitro and is required to mediate the activation of the Sox3 promoter by TR/RXR in the presence of T3 in reconstituted frog oocyte transcription system (XREF_FIG)."
27567710
RAC1 affects USP6
1 1 1 |
RAC1 increases the amount of USP6.
1 |
GTP-bound active RAC1 increases the amount of USP6. 1 / 1
1 |
bel
"Coexpression of activated alleles of Cdc42 or Rac1 also caused complete redistribution of TRE17 to the plasma membrane, where it partially colocalized with the GTPases in filopodia and ruffles, respectively."
12612085
RAC1 binds USP6.
1 |
USP6 binds RAC1. 1 / 1
1 |
biogrid
No evidence text available
12612085
RAC1 activates USP6.
1 |
RAC1 activates USP6. 1 / 1
1 |
signor
"In quiescent cells, tre17 is localized to intracellular filamentous and punctate structures in the cytoplasm, folded in an inactive conformation. Upon growth factor addition, cdc42 and rac1 become activated and recruit tre17 to the plasma membrane. Stable membrane localization of tre17 also requires polymerized actin. This recruitment process leads to a conformational change in tre17, such that the n-terminal portion of the molecule further stimulates the accumulation of cortical actin."
12612085
PNA1 affects USP6
| 3
USP6 binds PNA1. 3 / 3
| 3
reach
"In our experimental system, binding of RNA and PNA1 to HRP1 resulted in similar changes in the CD signal, decrease at 240-260 nm and increase at 280-290 nm, which were fully consistent with the CD spectra previously observed for the triple helical binding of cytosine rich PNA to double stranded DNA."
20527745
reach
"Next, we tested the binding of PNA1 to HRP1 at physiological pH (XREF_TABLE, entry 6)."
20527745
reach
"Finally, the CD spectra of RNA and PNA1 bound to HRP1 were fully consistent with previous results on PNA-DNA triple helices."
20527745
PAFAH1B1 affects USP6
| 3
USP6 binds PAFAH1B1. 3 / 3
| 3
sparser
"Subsequent next-generation sequencing-based technology revealed a novel PAFAH1B1-USP6 fusion gene as well as unusual fusion point on USP6 (exon 9)."
33161462
sparser
"Additionally, PAFAH1B1-USP6 fusion has never been described in NF."
33161462
sparser
"Atypical nodular fasciitis with a novel PAFAH1B1-USP6 fusion in a 22-month-old boy."
33161462
NMDAR affects USP6
| 3
USP6 binds NMDAR. 2 / 2
| 2
sparser
"Together, these results indicate that USP6 can interact with NMDAR subunits and promotes their stabilization by reducing NMDAR ubiquitination."
31841517
sparser
"After establishing a role for USP6 in modulating NMDAR ubiquitination and expression, we determined whether USP6 interacts with NMDAR subunits."
31841517
USP6 binds HMBS, NMDAR, and NMDAR. 1 / 1
| 1
sparser
"USP6 interacts with NMDARs to attenuate UPS-mediated NMDAR turnover."
31841517
KRAS affects USP6
| 3
USP6 binds KRAS and EGFP. 2 / 2
| 2
sparser
"We further generated ankrd45 mutants carrying a doxycycline-inducible transgenic line, Tg ( fabp10:rtTA2s-M2 ;TRE2:EGFP-kras G12V ), which contained a liver-specific double transgene to induce the expression of EGFP-Kras G12V specifically in the liver [ xref , xref ]."
31208154
sparser
"In this study, transgenic zebrafish Tg(fabp10:rtTA2s-M2; TRE2:EGFP-KRAS G12V ), a hepatocellular carcinoma (HCC) model that can cause liver tumorigenesis by doxycycline (DOX) induction, was used to investigate the effect of PFOS exposure in HCC progression."
33675800
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
JUN affects USP6
3 |
USP6 binds JUN. 3 / 3
3 |
biogrid
No evidence text available
29061731
biogrid
No evidence text available
29061731
biogrid
No evidence text available
29061731
JAK1 affects USP6
| 2 1
JAK1 inhibits USP6.
| 1
JAK1 inhibits USP6. 1 / 1
| 1
reach
"Strikingly, both complete and partial depletion of Jak1 significantly reduced the mass of USP6 induced tumors (XREF_FIG)."
27440725
JAK1 binds USP6.
| 1
USP6 binds JAK1. 1 / 1
| 1
sparser
"USP6 associates with Jak1, and mediates its de-ubiquitination in vivo and in vitro ."
27440725
JAK1 activates USP6.
| 1
JAK1 activates USP6. 1 / 1
| 1
reach
"Strikingly, we found that Jak1 levels were significantly increased in NIH3T3 and MC3T3 cell lines expressing USP6, in a dox dependent manner (XREF_FIG)."
27440725
GLS affects USP6
| 3
USP6 binds GLS. 3 / 3
| 3
sparser
"Together, these findings indicated that USP6 interacted with GLS1 and inhibited GLS1 ubiquitination."
35091542
sparser
"USP6 interacted with GLS1 and inhibited GLS1 ubiquitination in CML cells."
35091542
sparser
"Further studies showed that USP6 interacted with GLS1 and inhibited GLS1 ubiquitination in CML cells."
35091542
FOS1 affects USP6
| 3
USP6 binds FOS1. 3 / 3
| 3
sparser
"When MEK-1 and KGB-1 were co-expressed with T7-FOS-1 in COS-7 cells, the association of FOS-1 with the optimal TRE2 probe was decreased ( xref , lanes 1–3)."
23437011
sparser
"To examine whether FOS-1 binds directly to the kreg-1 promoter via TRE2, we conducted chromatin immunoprecipitation (ChIP) assays."
23437011
sparser
"In this model, FOS-1 forms homodimers and binds to the TRE2 motif in the kreg-1 promoter."
23437011
COL6A2 affects USP6
| 3
USP6 binds COL6A2. 3 / 3
| 3
sparser
"For example, the COL6A2-USP6 fusion that was initially missed by RNA-seq because of low fusion fragments per million (< 0.1) combined with the absence of COL6A2 or USP6 on the inclusion list. (4) Finally, RNA-seq has a longer turnaround time of 7-21 days compared with more targeted approaches."
35085008
sparser
"In case PMABM000BJK/27, a COL6A2-USP6 fusion was identified in routine diagnostics by targeted RNA-seq (Archer FusionPlex Sarcoma, Invitae, Boulder, CO) but not identified using RNA-seq."
35085008
sparser
"Nodular Fasciitis With Malignant Morphology and a COL6A2-USP6 Fusion: A Case Report (of a 10-Year-old Boy)."
33625261
CDC42 affects USP6
1 1 1 |
CDC42 increases the amount of USP6.
1 |
GTP-bound active CDC42 increases the amount of USP6. 1 / 1
1 |
bel
"Coexpression of activated alleles of Cdc42 or Rac1 also caused complete redistribution of TRE17 to the plasma membrane, where it partially colocalized with the GTPases in filopodia and ruffles, respectively."
12612085
CDC42 binds USP6.
1 |
USP6 binds CDC42. 1 / 1
1 |
biogrid
No evidence text available
12612085
CDC42 activates USP6.
1 |
CDC42 activates USP6. 1 / 1
1 |
signor
"In quiescent cells, tre17 is localized to intracellular filamentous and punctate structures in the cytoplasm, folded in an inactive conformation. Upon growth factor addition, cdc42 and rac1 become activated and recruit tre17 to the plasma membrane. Stable membrane localization of tre17 also requires polymerized actin. This recruitment process leads to a conformational change in tre17, such that the n-terminal portion of the molecule further stimulates the accumulation of cortical actin."
12612085
CALM2 affects USP6
3 |
USP6 binds CALM2. 3 / 3
3 |
biogrid
No evidence text available
16127172
biogrid
No evidence text available
16127172
biogrid
No evidence text available
16127172
AHNAK affects USP6
| 3
USP6 binds AHNAK. 3 / 3
| 3
sparser
"Herein, we report a case of a 29-year-old female with a synchronous polyostotic solid variant of ABC involving her T7-T11 posterior elements of her thoracic vertebrae with a novel AHNAK::USP6 fusion, detected by next-generation sequencing (NGS)."
35717456
sparser
"This case is distinguished by its synchronous polyostotic presentation, solid rather than classic ABC morphology and novel AHNAK::USP6 fusion, which has not been previously reported in ABC or in any mesenchymal bone tumor."
35717456
sparser
"Synchronous polyostotic solid variant of aneurysmal bone cyst involving thoracic vertebrae and harboring a novel AHNAK::USP6 gene fusion."
35717456
Valproic acid affects USP6
2 |
Valproic acid methylates USP6.
1 |
Valproic acid methylates USP6. 1 / 1
1 |
ctd
No evidence text available
29154799
Valproic acid increases the amount of USP6.
1 |
Valproic acid increases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
23527032
Thraa affects TRα1PV
| 2
USP6 binds thraa and TRα1PV. 2 / 2
| 2
sparser
"Using similar EMSA, we also found specific binding of TRα1 ( xref , lanes 5–9) and TRα1PV ( xref , lanes 11–15) to TRE2."
28910278
sparser
"Similar significantly higher binding of TRα1 (bar 3 versus bar 1, xref ) and TRα1PV (bar 6 versus bar 2, xref ) to TRE2 ( CCCACG GAGAT TCCTGT , in the region -3699 to -3325 bp) were also detected."
28910278
USP9X affects USP6
| 2
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
USP6 affects response signature
| 2
USP6 activates response signature. 2 / 2
| 2
eidos
"This study demonstrates that high USP6 expression is associated with all of these hot TME hallmarks in ES patients , and that USP6 is sufficient to drive an IFN response signature and CXCL10 expression in vitro , as well as intra-tumoral immune cell recruitment and activation in vivo ."
33558334
eidos
"We found that USP6 is sufficient to trigger an IFN response gene signature , both in ES cells and other neoplastic models ( 17 ) ."
33558334
USP6 affects cell cycle
| 1 1
USP6 activates cell cycle. 2 / 2
| 1 1
eidos
"USP6 depletion caused cell cycle arrest and a deficiency in CDD repair mediated through instability of poly ( ADP-ribose ) polymerase-1 ( PARP-1 ) protein ."
30851349
reach
"USP6 depletion caused cell cycle arrest and a deficiency in CDD repair mediated through instability of poly (ADP-ribose) polymerase-1 (PARP-1) protein."
30851349
USP6 affects USP9X
| 2
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
USP6 affects USP1
| 2
USP1 binds USP6. 2 / 2
| 2
sparser
"Properties of the Six USPs (USP1–USP6) as Putative Allergenic Proteins."
31947554
sparser
"Nevertheless, signal peptide prediction enabled identification of six genes encoding uncharacterized secretory proteins (USPs; USP1–USP6) that were commonly expressed in all examined social wasps, bumblebees, and one solitary hunting wasp, A. flavomarginatum ( xref )."
31947554
USP6 affects Troponin_C
| 2
Troponin_C binds USP6. 2 / 2
| 2
sparser
"Cellular Fibroma of Tendon Sheath With Novel TNC-USP6 Gene Fusion Clinically Mimicking Arthritis in a 7-Year-Old Boy."
34520696
sparser
"We report a case of a pediatric patient with thumb swelling clinically concerning for arthritis with a biopsy demonstrating myofibroblastic proliferation with features consistent with NF/CFTS, and molecular studies confirming the presence of a USP6 gene fusion (TNC-USP6)."
34520696
USP6 affects TRα1PV
| 2
USP6 binds thraa and TRα1PV. 2 / 2
| 2
sparser
"Using similar EMSA, we also found specific binding of TRα1 ( xref , lanes 5–9) and TRα1PV ( xref , lanes 11–15) to TRE2."
28910278
sparser
"Similar significantly higher binding of TRα1 (bar 3 versus bar 1, xref ) and TRα1PV (bar 6 versus bar 2, xref ) to TRE2 ( CCCACG GAGAT TCCTGT , in the region -3699 to -3325 bp) were also detected."
28910278
USP6 affects TRalpha1PV
| 2
USP6 binds TRalpha1PV. 2 / 2
| 2
reach
"To demonstrate the binding of TRalpha1PV to TRE2, we used anti-TRalpha1PV specific antibodies, T1, in the ChIP assays."
29273766
reach
"In contrast, specific binding of TRalpha1PV to TRE2 was detected (compare bar 6 with bar 5), indicating that TRalpha1PV was bound to the promoter of the Gata1 gene."
29273766
USP6 affects TRE1
| 2
USP6 binds TRE1. 2 / 2
| 2
sparser
"Taken together, these results suggest that TR/RXR binds independently to both TRE1 and TRE2."
16899449
sparser
"ASH1 turned out to possess a surprising specificity in that it binds in vitro sense tre1 , tre2 and tre3 RNAs, but not the antisense counterparts."
16732899
USP6 affects TRE
| 2
USP6 binds TRE. 2 / 2
| 2
sparser
"Furthermore, both TREs were capable of binding to TR/RXR heterodimers in vitro with TRE2 having a higher affinity."
22800560
sparser
"Thus, both TREs could bind to TR/RXR with TRE2 having a higher affinity in vitro."
22800560
USP6 affects TBC1 domain
| 2
GDP binds USP6 and TBC1 domain. 2 / 2
| 2
reach
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy ) and the TRE17 oncogene ."
21587297
reach
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy 49 ) and the TRE17 oncogene 50 ."
21587297
USP6 affects STAG1
| 2
STAG1 binds USP6. 2 / 2
| 2
sparser
"Periosteal Fasciitis With Unusual Radiologic Features Harboring a Novel STAG1::USP6 Fusion Gene."
36694417
sparser
"Molecular analysis revealed a novel STAG1::USP6 fusion that helped arrive at the right diagnosis and further expands the molecular profile of USP6 -associated neoplasms."
36694417
USP6 affects SMAD4
| 2
USP6 increases the amount of SMAD4.
| 1
USP6 increases the amount of SMAD4. 1 / 1
| 1
reach
"USP6 was a target of miR-130a and the overexpression of miR-130a or inhibition of USP6 in UM MUM-2B and MUM-2C cell lines inhibited the expression of Wnt, β-catenin, and EGFR, and activated SMAD4 expression, while reducing UM cell migration and invasion abilities in vitro."
34522027
USP6 decreases the amount of SMAD4.
| 1
USP6 decreases the amount of SMAD4. 1 / 1
| 1
reach
"USP6 was a target of miR-130a and the overexpression of miR-130a or inhibition of USP6 in UM MUM-2B and MUM-2C cell lines inhibited the expression of Wnt, β-catenin, and EGFR, and activated SMAD4 expression, while reducing UM cell migration and invasion abilities in vitro."
34522027
eidos
"We demonstrated that depletion of USP6 causes significantly increased radiosensitivity to high-LET IR ( low-energy protons and alpha-particles ) , but not low-LET IR ( high-energy protons or x-ray irradiation ) , which is mediated by instability of PARP-1 protein levels , a subsequent deficiency in CDD repair , and G2 / M cell cycle checkpoint arrest ."
30851349
eidos
"We recently demonstrated using a DUB siRNA screen , that depletion of USP6 causes significantly increased radiosensitivity to high-LET IR ( relatively high-LET protons and alpha-particles ) but not low-LET IR ( protons or X-rays ) , which was mediated by instability of PARP-1 required for CDD repair ( 7 ) ."
34277417
USP6 affects RNA15
| 2
USP6 binds RNA15. 2 / 2
| 2
reach
"17 The interaction of Rna15 and Hrp1 with the scaffolding protein Rna14 increases the efficiency of with which these sequences are recognized, yet RNA association is solely mediated by the RNA binding domains of Hrp1 and Rna15."
20600122
reach
"The contact with Hrp1 bound at the adjacent enhancer element, positions Rna15 precisely; Rna14 further locks these proteins in place by increasing the efficiency of the Hrp1 and Rna15 interaction."
20600122
USP6 affects RNA14
| 2
USP6 binds RNA14. 2 / 2
| 2
reach
"Rna14 can further associate with Pcf11 and Hrp1 and also binds the Pfs2 and Cft1 subunits of CPF."
17151076
reach
"The Hrp1/Rna14 interaction has been mapped to Hrp1 RRMs by NMR (Barnwal et al, 2012), but the structural details remain unknown."
35022249
USP6 affects PNA5
| 2
USP6 binds PNA5. 2 / 2
| 2
reach
"Similar transitions unique to the matched PNA5 and HRP1 complex were also observed in CD melting plots (XREF_SUPPLEMENTARY)."
23125029
reach
"UV thermal melting (XREF_SUPPLEMENTARY) of the matched PNA5 and HRP1 complex showed a broad and relatively weak transition at ~ 55 degreesC that might be assigned to triplex melting preceding the melting of the HRP1 hairpin at ~ 100 degreesC."
23125029
USP6 affects PMS1
| 2
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
USP6 affects PLA1A
| 2
USP6 activates PLA1A. 2 / 2
| 2
reach
"In this study, we have demonstrated that the RNA binding protein Hrp1 and Nab4 modulates the activity of the NMD pathway in yeast."
10882134
reach
"Thus, Hrp1p and Nab4p specifically interacts with the DSE from PGK1, and this interaction requires the presence of the sequence motifs.We asked whether the inability of hrp1 strains to promote NMD was[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10882134
reach
"As an independent prognostic factor, USP6 promotes the invasion and metastasis of colon cancer."
30297112
reach
"Furthermore, cell function assay demonstrated that USP6 could promote colon cancer cells ' invasion invitro and liver metastasis invivo."
30297112
USP6 affects MMP10
1 | 1
Transcriptionally active USP6 increases the amount of MMP10. 1 / 1
1 |
signor
"In this study we show that tre17 is sufficient to induce expression of mmp-9 and mmp-10, in a manner requiring its usp activity, but not its ability to bind arf6. Tre17 induces transcription of mmp-9 through activation of nuclear factor-kappab (nf-kappab), mediated in part by the gtpase rhoa and its effector kinase, rock."
20418905
USP6 increases the amount of MMP10. 1 / 1
| 1
reach
"XREF_BIBR USP6 is sufficient to induce the expression of MMP9 and MMP10."
32904569
USP6 affects MED15
| 2
USP6 binds MED15. 2 / 2
| 2
reach
"The Med15 and Hrp1 complex can associate with L-Mediator, and the subcomplex plays a role in the regulated transcription of some fission yeast genes."
28515143
reach
"Instead, Med15 forms a complex with Hrp1, a CHD1 ATP dependent chromatin remodeling protein."
28515143
USP6 affects LUM
| 2
USP6 binds LUM. 2 / 2
| 2
sparser
"We report a novel t(12;17)(q21;p13) chromosome translocation which gave rise to a LUM-USP6 fusion in an aneurysmal bone cyst."
32859633
sparser
"RNA sequencing detected LUM-USP6 and USP6-LUM fusion transcripts which were subsequently verified by RT-PCR/Sanger sequencing."
32859633
USP6 affects LRP6
| 2
USP6 increases the amount of LRP6.
| 1
USP6 increases the amount of LRP6. 1 / 1
| 1
reach
"USP6 has also been shown to regulate cell surface abundance of LRP6 as expression of wild-type USP6 increases surface levels of LRP6."
34414184
USP6 activates LRP6.
| 1
USP6 activates LRP6. 1 / 1
| 1
reach
"Contrary to RNF43, ubiquitin specific protease 6 (USP6) is a deubiquitylase; ectopic expression of USP6 increases cell surface abundance of Fzds and Lrp6 and activates beta-catenin pathway in tumor cells XREF_BIBR."
32998794
USP6 affects IKK_complex
| 2
IKK_complex binds USP6 and RELA. 1 / 1
| 1
sparser
"TRE17 associates with IKK and promotes its activation, leading to phosphorylation of p65 on S536."
22081069
IKK_complex binds USP6. 1 / 1
| 1
sparser
"To explore how this might occur we examined whether TRE17(long) associates with the IKK complex, which consists of the catalytic subunits IKKα and IKKβ, and the regulatory subunit NEMO."
22081069
USP6 affects Hrp1p
| 2
USP6 inhibits Hrp1p. 2 / 2
| 2
reach
"A mutation in HRP1 that results in the stabilization of nonsense containing mRNAs abolishes the affinity of the Hrp1p for the DSE and fails to interact with Upf1p."
10882134
reach
"A mutation in HRP1 that resulted in the stabilization of nonsense containing mRNAs abolished the affinity of the Hrp1p for the DSE."
11674994
USP6 affects Histone_H3
| 2
USP6 inhibits Histone_H3. 2 / 2
| 2
reach
"We show that, in addition to centromeric regions, a low level of CENP-A (Cnp1) associates with gene promoters where histone H3 is depleted by the activity of the Hrp1 (Chd1) chromatin remodeling factor."
21531710
reach
"It is perhaps less surprising that the strong increase in H3 occupancy does not restrict chromatin accessibility since previous studies in fission yeast revealed that hrp1 and hrp3 deletions increase promoter H3 occupancy but do not affect MNase sensitivity of promoter regions [XREF_BIBR, XREF_BIBR]."
25621013
USP6 affects HEL
| 2
USP6 bound to NAB2 inhibits HEL. 1 / 1
| 1
reach
"These experiments reveal that these interactions do not depend on the presence of RNA, as interactions between Caf1 and Hrp1 or Caf1 and Nab2 were not reduced following RNase treatment (XREF_FIG and data not shown)."
21464899
USP6 bound to CNOT7 inhibits HEL. 1 / 1
| 1
reach
"These experiments reveal that these interactions do not depend on the presence of RNA, as interactions between Caf1 and Hrp1 or Caf1 and Nab2 were not reduced following RNase treatment (XREF_FIG and data not shown)."
21464899
USP6 affects GDP
| 2
GDP binds USP6 and TBC1 domain. 2 / 2
| 2
reach
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy ) and the TRE17 oncogene ."
21587297
reach
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy 49 ) and the TRE17 oncogene 50 ."
21587297
USP6 affects EGFP
| 2
USP6 binds KRAS and EGFP. 2 / 2
| 2
sparser
"We further generated ankrd45 mutants carrying a doxycycline-inducible transgenic line, Tg ( fabp10:rtTA2s-M2 ;TRE2:EGFP-kras G12V ), which contained a liver-specific double transgene to induce the expression of EGFP-Kras G12V specifically in the liver [ xref , xref ]."
31208154
sparser
"In this study, transgenic zebrafish Tg(fabp10:rtTA2s-M2; TRE2:EGFP-KRAS G12V ), a hepatocellular carcinoma (HCC) model that can cause liver tumorigenesis by doxycycline (DOX) induction, was used to investigate the effect of PFOS exposure in HCC progression."
33675800
USP6 affects DOT1L
| 2
USP6 activates DOT1L. 2 / 2
| 2
reach
"Thus, TRE2 likely mediates the induction of Dot1L by T3 in different organs during metamorphosis."
22800560
reach
"To determine whether TRE1 and TRE2 can mediate the transcriptional regulation of the Dot1L gene by T3 in vivo, we used a reconstituted Xenopus laevis oocyte transcription system, which allows the analysis of the promoter in the context of chromatin in vivo [XREF_BIBR]."
22800560
USP6 affects Ccr4-Not
| 2
USP6 binds Ccr4-Not. 2 / 2
| 2
reach
"We augment these preliminary findings by demonstrating that multiple components of the budding yeast Ccr4 and Not complex associate with the PRMT1 homolog, Hmt1, and that Ccr4-Not also associates with the Hmt1 substrates, Hrp1 and Nab2 in an Hmt1 methyltransferase dependent fashion XREF_BIBR, XREF_BIBR."
21464899
reach
"Furthermore, using genetic and biochemical approaches, we demonstrate that Ccr4-Not physically and functionally interacts with the heterogenous nuclear ribonucleoproteins (hnRNPs) Nab2 and Hrp1, and that the physical association depends on Hmt1 methyltransferase activity."
21464899
USP6 affects CXCL10
| 2
USP6 activates CXCL10. 2 / 2
| 2
eidos
"This study demonstrates that high USP6 expression is associated with all of these hot TME hallmarks in ES patients , and that USP6 is sufficient to drive an IFN response signature and CXCL10 expression in vitro , as well as intra-tumoral immune cell recruitment and activation in vivo ."
33558334
eidos
"As shown in Figure 2C , the first STAT1 site , both NF-kappaB sites , and the ISRE all contributed to activation of the CXCL10 promoter by USP6 + IFNgamma , whereas the AP-1 site was largely dispensable ."
33558334
USP6 affects CNOT7
| 2
USP6 binds CNOT7. 2 / 2
| 2
reach
"While we detected Hrp1 in the Caf1-Myc immunoprecipitates, the amount of Hrp1 co-immunoprecipitated with Caf1-Myc was profoundly reduced in hmt1Delta cells relative to cells expressing HMT1 (XREF_FIG), suggesting that the interaction between Caf1 and Hrp1 is Hmt1 dependent."
21464899
reach
"These experiments reveal that these interactions do not depend on the presence of RNA, as interactions between Caf1 and Hrp1 or Caf1 and Nab2 were not reduced following RNase treatment (XREF_FIG and data not shown)."
21464899
USP6 affects CDC16
| 2
USP6 binds CDC16 and BUB2. 2 / 2
| 2
sparser
"Furthermore, the ATG8 family of ubiquitin-like proteins have been reported to interact with a number of the Tre2, Bub2 and Cdc16 (TBC)-1 domain-containing family members which act as GTPase-activating proteins (GAPs) to small Rab GTPases involved in endocytosis [ xref ]."
29233871
sparser
"EVI5 contains a TBC domain [4] since it shows homologies with other genes such as TRE2, BUB2, and CDC16 [5,6] which are associated with development, regulation of the cell cycle, and oncogenesis [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16033705
USP6 affects CDA
| 2
USP6 activates CDA. 2 / 2
| 2
reach
"Using an enzyme-modified neutral comet assay after high-LET protons, we found that depletion of USP6 significantly reduces the efficiency of CDD repair (Fig. 4A [compare blue and yellow bars] and Fig. 4B), but not DSB repair, in comparison to NT control siRNA treated cells (Fig. 4A [compare green and red bars] and Fig. 4C)."
30851349
reach
"USP6 depletion caused cell cycle arrest and a deficiency in CDD repair mediated through instability of poly(ADP-ribose) polymerase-1 (PARP-1) protein."
30851349
USP6 affects CALD1
| 2
USP6 binds CALD1. 2 / 2
| 2
sparser
"Fluorescence in situ hybridization demonstrated a USP6 translocation, confirmed by next-generation sequencing to be the novel CALD1-USP6 fusion."
34213575
sparser
"Morphologically malignant nodular fasciitis with CALD1-USP6 fusion."
34213575
USP6 affects BUB2
| 2
USP6 binds CDC16 and BUB2. 2 / 2
| 2
sparser
"Furthermore, the ATG8 family of ubiquitin-like proteins have been reported to interact with a number of the Tre2, Bub2 and Cdc16 (TBC)-1 domain-containing family members which act as GTPase-activating proteins (GAPs) to small Rab GTPases involved in endocytosis [ xref ]."
29233871
sparser
"EVI5 contains a TBC domain [4] since it shows homologies with other genes such as TRE2, BUB2, and CDC16 [5,6] which are associated with development, regulation of the cell cycle, and oncogenesis [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16033705
USP6 affects ATXN7L3
1 1 |
USP6 binds ATXN7L3. 2 / 2
1 1 |
hprd
No evidence text available
16713569
biogrid
No evidence text available
16713569
USP6 affects ABC transporters
| 2
USP6 binds ABC transporters. 2 / 2
| 2
sparser
"It has been said that ABC is associated with distinctive 17p13 translocations that result in up-regulation of USP6, a deubiquitinating enzyme.[ xref ]"
23853640
sparser
"The mechanism by which USP6 upregulation causes ABC formation has not yet been elucidated."
19838726
USP1 affects USP6
| 2
USP1 binds USP6. 2 / 2
| 2
sparser
"Properties of the Six USPs (USP1–USP6) as Putative Allergenic Proteins."
31947554
sparser
"Nevertheless, signal peptide prediction enabled identification of six genes encoding uncharacterized secretory proteins (USPs; USP1–USP6) that were commonly expressed in all examined social wasps, bumblebees, and one solitary hunting wasp, A. flavomarginatum ( xref )."
31947554
Troponin_C affects USP6
| 2
Troponin_C binds USP6. 2 / 2
| 2
sparser
"Cellular Fibroma of Tendon Sheath With Novel TNC-USP6 Gene Fusion Clinically Mimicking Arthritis in a 7-Year-Old Boy."
34520696
sparser
"We report a case of a pediatric patient with thumb swelling clinically concerning for arthritis with a biopsy demonstrating myofibroblastic proliferation with features consistent with NF/CFTS, and molecular studies confirming the presence of a USP6 gene fusion (TNC-USP6)."
34520696
TRα1PV affects thraa
| 2
USP6 binds thraa and TRα1PV. 2 / 2
| 2
sparser
"Using similar EMSA, we also found specific binding of TRα1 ( xref , lanes 5–9) and TRα1PV ( xref , lanes 11–15) to TRE2."
28910278
sparser
"Similar significantly higher binding of TRα1 (bar 3 versus bar 1, xref ) and TRα1PV (bar 6 versus bar 2, xref ) to TRE2 ( CCCACG GAGAT TCCTGT , in the region -3699 to -3325 bp) were also detected."
28910278
TRalpha1PV affects USP6
| 2
USP6 binds TRalpha1PV. 2 / 2
| 2
reach
"To demonstrate the binding of TRalpha1PV to TRE2, we used anti-TRalpha1PV specific antibodies, T1, in the ChIP assays."
29273766
reach
"In contrast, specific binding of TRalpha1PV to TRE2 was detected (compare bar 6 with bar 5), indicating that TRalpha1PV was bound to the promoter of the Gata1 gene."
29273766
TRE1 affects USP6
| 2
USP6 binds TRE1. 2 / 2
| 2
sparser
"Taken together, these results suggest that TR/RXR binds independently to both TRE1 and TRE2."
16899449
sparser
"ASH1 turned out to possess a surprising specificity in that it binds in vitro sense tre1 , tre2 and tre3 RNAs, but not the antisense counterparts."
16732899
TRE affects USP6
| 2
USP6 binds TRE. 2 / 2
| 2
sparser
"Furthermore, both TREs were capable of binding to TR/RXR heterodimers in vitro with TRE2 having a higher affinity."
22800560
sparser
"Thus, both TREs could bind to TR/RXR with TRE2 having a higher affinity in vitro."
22800560
TGFB affects USP6
| 2
TGFB inhibits USP6.
| 1
TGFB inhibits USP6. 1 / 1
| 1
reach
"MTT proliferation assays revealed that each TGFB isoform decreased HRP-1 cell growth in a dose dependent manner, whereas RCHO-1 cells were resistant to the growth-suppressive effect of TGFB1 and TGFB3."
20926802
TGFB activates USP6.
| 1
TGFB activates USP6. 1 / 1
| 1
reach
"Activation of ERK, MAPK14 (p38 MAPK), or SMAD pathways is known to play a role in cell proliferation, and we found that TGFB activates these pathways in both HRP-1 and RCHO-1 cells in an isoform specific manner."
20926802
TBC1 domain affects USP6
| 2
GDP binds USP6 and TBC1 domain. 2 / 2
| 2
reach
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy ) and the TRE17 oncogene ."
21587297
reach
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy 49 ) and the TRE17 oncogene 50 ."
21587297
STAG1 affects USP6
| 2
STAG1 binds USP6. 2 / 2
| 2
sparser
"Periosteal Fasciitis With Unusual Radiologic Features Harboring a Novel STAG1::USP6 Fusion Gene."
36694417
sparser
"Molecular analysis revealed a novel STAG1::USP6 fusion that helped arrive at the right diagnosis and further expands the molecular profile of USP6 -associated neoplasms."
36694417
RNA15 affects USP6
| 2
USP6 binds RNA15. 2 / 2
| 2
reach
"17 The interaction of Rna15 and Hrp1 with the scaffolding protein Rna14 increases the efficiency of with which these sequences are recognized, yet RNA association is solely mediated by the RNA binding domains of Hrp1 and Rna15."
20600122
reach
"The contact with Hrp1 bound at the adjacent enhancer element, positions Rna15 precisely; Rna14 further locks these proteins in place by increasing the efficiency of the Hrp1 and Rna15 interaction."
20600122
RNA14 affects USP6
| 2
USP6 binds RNA14. 2 / 2
| 2
reach
"Rna14 can further associate with Pcf11 and Hrp1 and also binds the Pfs2 and Cft1 subunits of CPF."
17151076
reach
"The Hrp1/Rna14 interaction has been mapped to Hrp1 RRMs by NMR (Barnwal et al, 2012), but the structural details remain unknown."
35022249
PNA5 affects USP6
| 2
USP6 binds PNA5. 2 / 2
| 2
reach
"Similar transitions unique to the matched PNA5 and HRP1 complex were also observed in CD melting plots (XREF_SUPPLEMENTARY)."
23125029
reach
"UV thermal melting (XREF_SUPPLEMENTARY) of the matched PNA5 and HRP1 complex showed a broad and relatively weak transition at ~ 55 degreesC that might be assigned to triplex melting preceding the melting of the HRP1 hairpin at ~ 100 degreesC."
23125029
PMS1 affects USP9X
| 2
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
MED15 affects USP6
| 2
USP6 binds MED15. 2 / 2
| 2
reach
"The Med15 and Hrp1 complex can associate with L-Mediator, and the subcomplex plays a role in the regulated transcription of some fission yeast genes."
28515143
reach
"Instead, Med15 forms a complex with Hrp1, a CHD1 ATP dependent chromatin remodeling protein."
28515143
LUM affects USP6
| 2
USP6 binds LUM. 2 / 2
| 2
sparser
"We report a novel t(12;17)(q21;p13) chromosome translocation which gave rise to a LUM-USP6 fusion in an aneurysmal bone cyst."
32859633
sparser
"RNA sequencing detected LUM-USP6 and USP6-LUM fusion transcripts which were subsequently verified by RT-PCR/Sanger sequencing."
32859633
KRAS affects EGFP
| 2
USP6 binds KRAS and EGFP. 2 / 2
| 2
sparser
"We further generated ankrd45 mutants carrying a doxycycline-inducible transgenic line, Tg ( fabp10:rtTA2s-M2 ;TRE2:EGFP-kras G12V ), which contained a liver-specific double transgene to induce the expression of EGFP-Kras G12V specifically in the liver [ xref , xref ]."
31208154
sparser
"In this study, transgenic zebrafish Tg(fabp10:rtTA2s-M2; TRE2:EGFP-KRAS G12V ), a hepatocellular carcinoma (HCC) model that can cause liver tumorigenesis by doxycycline (DOX) induction, was used to investigate the effect of PFOS exposure in HCC progression."
33675800
Interferon affects USP6
| 2
Interferon binds USP6. 2 / 2
| 2
sparser
"In addition, USP6 expression was associated with an IFN response in germ cell tumors."
30131449
sparser
"We next explored whether USP6 was associated with an IFN response in other tumor types."
30131449
IKK_complex affects USP6
| 2
IKK_complex binds USP6 and RELA. 1 / 1
| 1
sparser
"TRE17 associates with IKK and promotes its activation, leading to phosphorylation of p65 on S536."
22081069
IKK_complex binds USP6. 1 / 1
| 1
sparser
"To explore how this might occur we examined whether TRE17(long) associates with the IKK complex, which consists of the catalytic subunits IKKα and IKKβ, and the regulatory subunit NEMO."
22081069
GRIN1 affects USP6
| 2
GRIN1 ubiquitinates USP6. 1 / 1
| 1
sparser
"USP6 transgenic mice had reduced GluN1 ubiquitination and depletion of USP6 in human embryonic stem cells differentiated into excitatory neurons resulted in a reduction in surface GluN1 leading to a model that the presence of USP6 stabilizes NMDA receptors perhaps through their recycling to the membrane ( xref )."
34197891
GRIN1 ubiquitinates USP6. 1 / 1
| 1
sparser
"USP6 transgenic mice had reduced GluN1 ubiquitination and depletion of USP6 in human embryonic stem cells differentiated into excitatory neurons resulted in a reduction in surface GluN1 leading to a model that the presence of USP6 stabilizes NMDA receptors perhaps through their recycling to the membrane ( xref )."
34197891
GDP affects USP6
| 2
GDP binds USP6 and TBC1 domain. 2 / 2
| 2
reach
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy ) and the TRE17 oncogene ."
21587297
reach
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy 49 ) and the TRE17 oncogene 50 ."
21587297
EGFP affects USP6
| 2
USP6 binds KRAS and EGFP. 2 / 2
| 2
sparser
"We further generated ankrd45 mutants carrying a doxycycline-inducible transgenic line, Tg ( fabp10:rtTA2s-M2 ;TRE2:EGFP-kras G12V ), which contained a liver-specific double transgene to induce the expression of EGFP-Kras G12V specifically in the liver [ xref , xref ]."
31208154
sparser
"In this study, transgenic zebrafish Tg(fabp10:rtTA2s-M2; TRE2:EGFP-KRAS G12V ), a hepatocellular carcinoma (HCC) model that can cause liver tumorigenesis by doxycycline (DOX) induction, was used to investigate the effect of PFOS exposure in HCC progression."
33675800
Ccr4-Not affects USP6
| 2
USP6 binds Ccr4-Not. 2 / 2
| 2
reach
"We augment these preliminary findings by demonstrating that multiple components of the budding yeast Ccr4 and Not complex associate with the PRMT1 homolog, Hmt1, and that Ccr4-Not also associates with the Hmt1 substrates, Hrp1 and Nab2 in an Hmt1 methyltransferase dependent fashion XREF_BIBR, XREF_BIBR."
21464899
reach
"Furthermore, using genetic and biochemical approaches, we demonstrate that Ccr4-Not physically and functionally interacts with the heterogenous nuclear ribonucleoproteins (hnRNPs) Nab2 and Hrp1, and that the physical association depends on Hmt1 methyltransferase activity."
21464899
CNOT7 affects USP6
| 2
USP6 binds CNOT7. 2 / 2
| 2
reach
"While we detected Hrp1 in the Caf1-Myc immunoprecipitates, the amount of Hrp1 co-immunoprecipitated with Caf1-Myc was profoundly reduced in hmt1Delta cells relative to cells expressing HMT1 (XREF_FIG), suggesting that the interaction between Caf1 and Hrp1 is Hmt1 dependent."
21464899
reach
"These experiments reveal that these interactions do not depend on the presence of RNA, as interactions between Caf1 and Hrp1 or Caf1 and Nab2 were not reduced following RNase treatment (XREF_FIG and data not shown)."
21464899
CDC16 affects USP6
| 2
USP6 binds CDC16 and BUB2. 2 / 2
| 2
sparser
"Furthermore, the ATG8 family of ubiquitin-like proteins have been reported to interact with a number of the Tre2, Bub2 and Cdc16 (TBC)-1 domain-containing family members which act as GTPase-activating proteins (GAPs) to small Rab GTPases involved in endocytosis [ xref ]."
29233871
sparser
"EVI5 contains a TBC domain [4] since it shows homologies with other genes such as TRE2, BUB2, and CDC16 [5,6] which are associated with development, regulation of the cell cycle, and oncogenesis [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16033705
CALD1 affects USP6
| 2
USP6 binds CALD1. 2 / 2
| 2
sparser
"Fluorescence in situ hybridization demonstrated a USP6 translocation, confirmed by next-generation sequencing to be the novel CALD1-USP6 fusion."
34213575
sparser
"Morphologically malignant nodular fasciitis with CALD1-USP6 fusion."
34213575
BUB2 affects USP6
| 2
USP6 binds CDC16 and BUB2. 2 / 2
| 2
sparser
"Furthermore, the ATG8 family of ubiquitin-like proteins have been reported to interact with a number of the Tre2, Bub2 and Cdc16 (TBC)-1 domain-containing family members which act as GTPase-activating proteins (GAPs) to small Rab GTPases involved in endocytosis [ xref ]."
29233871
sparser
"EVI5 contains a TBC domain [4] since it shows homologies with other genes such as TRE2, BUB2, and CDC16 [5,6] which are associated with development, regulation of the cell cycle, and oncogenesis [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16033705
Antirheumatic Agents increases the amount of USP6.
1 |
Antirheumatic Agents increases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
24449571
Antirheumatic Agents decreases the amount of USP6.
1 |
Antirheumatic Agents decreases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
25339124
ATXN7L3 affects USP6
1 1 |
USP6 binds ATXN7L3. 2 / 2
1 1 |
hprd
No evidence text available
16713569
biogrid
No evidence text available
16713569
ABC transporters affects USP6
| 2
USP6 binds ABC transporters. 2 / 2
| 2
sparser
"It has been said that ABC is associated with distinctive 17p13 translocations that result in up-regulation of USP6, a deubiquitinating enzyme.[ xref ]"
23853640
sparser
"The mechanism by which USP6 upregulation causes ABC formation has not yet been elucidated."
19838726
Translocation affects USP6
| 1
Translocation activates USP6. 1 / 1
| 1
eidos
"The most common translocation described ( 30 % ) , including for maxillofacial lesions , leads to fusion of the USP6 with CDH11 ( cadherin 11 ) genes which results in upregulation of USP6 [ 43-47 ] ."
31838586
reach
"Tra and Tre2 Interactions with RS 5 ~ ~ o4 ~ j V. Proteins In Vitro Tra Tra2 Purified proteins derived from expression in insect cells (Tra2, Tra, and SF2) or bacteria (hnRNP A1) were separated by SDS[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8124712
Tra affects USP6
| 1
USP6 binds tra and SR45A. 1 / 1
| 1
sparser
"Tra and Tre2 Interactions with RS 5~ ~o4~ j V. Proteins In Vitro Tra Tra2 Purified proteins derived from expression in insect cells (Tra2, Tra, and SF2) or bacteria (hnRNP A1) were sepa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8124712
Migration activate APCs TME affects USP6
| 1
Migration activate APCs TME activates USP6. 1 / 1
| 1
eidos
"USP6 expression in ES can also directly enhance NK cell activation , and we predict that USP6 would also promote activation of T cells in vivo due to their ability to stimulate their migration as well as activate APCs in the TME ."
33558334
MiR-145-5p affects USP6
| 1
MiR-145-5p inhibits USP6. 1 / 1
| 1
sparser
"The data suggested that miR-145-5p inhibited USP6 via binding to its 3′UTR."
35091542
Methylmercury chloride increases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
28001369
Indometacin affects USP6
1 |
Indometacin decreases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
28628672
Hsa-miR-423-5p affects USP6
1 |
Hsa-miR-423-5p decreases the amount of USP6. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-26b-5p affects USP6
1 |
Hsa-miR-26b-5p decreases the amount of USP6. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19088304
Hsa-miR-10b-5p affects USP6
1 |
Hsa-miR-10b-5p decreases the amount of USP6. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
25074381
Hrp1 affects USP6
| 1
USP6 binds HDGFL2 and hrp1. 1 / 1
| 1
sparser
"From initial characterization and genomic distribution, the Ysc, Chlamydiales, SPI-1, and SPI-2 families were associated with animal–bacterial interactions while the Rhizobiales, Hrp1, and Hrp2 families were associated with plant–bacterial interactions."
24575107
Histamine affects USP6
| 1
Histamine activates USP6. 1 / 1
| 1
reach
"We then examined if histamine may enhance NGF promoter activity in keratinocytes.It is reported that human NGF gene contains two TREs, TRE1 (-62/-56 bp) and TRE2 (+35/+41 bp), and these may act as enh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12925217
Gold atom affects USP6
| 1
reach
"Hrp1, the yeast CFIB and the counterpart of HLP1, binds AU rich EE and regulates correct positioning of the cleavage site and 3 '-end formation of pre-mRNAs XREF_BIBR, XREF_BIBR, XREF_BIBR."
26099751
Glucose affects USP6
| 1
Glucose activates USP6. 1 / 1
| 1
reach
"Conversely, glucose depletion enhanced only the formation of clear foci of Pab1-GFP, Pbp1-GFP, and Hrp1-GFP, but not Rpg1-GFP, Prt1-GFP, and Nip1-GFP in the cytoplasm."
23637899
Doxorubicin affects USP6
1 |
Doxorubicin decreases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
29803840
Dimethylarsinic acid increases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
17720352
Dexamethasone affects USP6
1 |
Dexamethasone decreases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
28628672
Copper(II) sulfate affects USP6
1 |
Copper(II) sulfate increases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
19549813
Calcium(2+) affects USP6
| 1
Calcium(2+) leads to the ubiquitination of USP6. 1 / 1
| 1
reach
"A possible hypothesis is that Ca 2+ / CaM promote the monoubiquitylation of USP6 by increasing its binding to ubiquitin ligase."
28659380
Cadmium(2+) affects USP6
| 1
Cadmium(2+) binds USP6. 1 / 1
| 1
reach
"Finally, the CD spectra of RNA and PNA1 bound to HRP1 were fully consistent with previous results on PNA-DNA triple helices."
20527745
Butanal affects USP6
1 |
Butanal decreases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
26079696
Bisphenol A affects USP6
1 |
Bisphenol A decreases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
28628672
Auxin affects USP6
| 1
Auxin activates USP6. 1 / 1
| 1
reach
"Using an auxin-induced Hrp1 depletion system, we identified new Hrp1-dependent attenuators in MNR2, SNG1, and RAD3 genes."
36315099
Aging affects USP6
1 |
Aging increases the amount of USP6. 1 / 1
1 |
bel
"Tables 2-7. Some differentially expressed genes (P <= 0.01 by t-test or rank sum test, q < 10%, and >= 1.3-fold difference) ratio old/young upregulated"
12783983
Aflatoxin B2 affects USP6
1 |
Aflatoxin B2 methylates USP6. 1 / 1
1 |
ctd
No evidence text available
30157460
Aflatoxin B1 affects USP6
1 |
Aflatoxin B1 demethylates USP6. 1 / 1
1 |
ctd
No evidence text available
30157460
Wnt affects USP6
| 1
Wnt activates USP6. 1 / 1
| 1
reach
"Inhibition of Wnt signaling using Dickkopf-1 (DKK1) or a Porcupine (PORCN) inhibitor significantly decreased the growth of USP6 driven xenograft tumors, indicating that Wnt signaling is a key target of USP6 during tumorigenesis."
27162353
VDR affects USP6
| 1
USP6 binds VDR. 1 / 1
| 1
sparser
"Aneurysmal bone cyst with an unusual clinical presentation and a novel VDR-USP6 fusion."
34369017
USP9X affects SETD2
| 1
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
USP9X affects KRAS
| 1
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
USP9X affects KMT2B
| 1
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
USP6
| 1
USP6 translocates to the membrane. 1 / 1
| 1
sparser
"Membrane recruitment of TRE17 by EGF or the GTPases was dependent on actin polymerization."
12612085
USP6 affects tumor growth
| 1
USP6 inhibits tumor growth. 1 / 1
| 1
eidos
"Although the effects did not reach statistical significance , there was a clear trend toward suppression of tumor growth by USP6 ."
33558334
USP6 affects transport
| 1
USP6 activates transport. 1 / 1
| 1
reach
"Two members of the tre-2 and USP6, BUB2, cdc16 (TBC1) domain family of proteins, Akt substrate of 160 kDa (also known as AS160 or TBC1D4) and TBC1D1, have been proposed as potential sites for the convergence of insulin and exercise signaling to stimulate glucose transport in skeletal muscle."
19955868
reach
"Tra and Tre2 Interactions with RS 5 ~ ~ o4 ~ j V. Proteins In Vitro Tra Tra2 Purified proteins derived from expression in insect cells (Tra2, Tra, and SF2) or bacteria (hnRNP A1) were separated by SDS[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8124712
USP6 affects tra
| 1
USP6 binds tra and SR45A. 1 / 1
| 1
sparser
"Tra and Tre2 Interactions with RS 5~ ~o4~ j V. Proteins In Vitro Tra Tra2 Purified proteins derived from expression in insect cells (Tra2, Tra, and SF2) or bacteria (hnRNP A1) were sepa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8124712
USP6 affects total infiltrated immune cells
| 1
USP6 activates total infiltrated immune cells. 1 / 1
| 1
eidos
"Strikingly , USP6 significantly increased total infiltrated immune cells , as monitored by the pan-leukocyte marker CD45 ( Figure 4D ) ."
33558334
USP6 affects signature
| 1
USP6 activates signature. 1 / 1
| 1
eidos
"USP6 synergistically enhances chemokine induction upon IFN treatment in vitro We previously reported that USP6 not only induces an IFN gene signature by itself , but that it also magnifies the response to exogenous Type I and II IFNs ( 17 ) ."
33558334
USP6 affects signature ES cells
| 1
USP6 activates signature ES cells. 1 / 1
| 1
eidos
"We previously showed that ubiquitin-specific protease 6 ( USP6 ) directly deubiquitinates and stabilizes Jak1 , thereby inducing an IFN signature in ES cells ."
33558334
USP6 affects same chemotaxis
| 1
USP6 activates same chemotaxis. 1 / 1
| 1
eidos
"In the patient-derived ES cell line RD-ES , upon addition of dox , USP6 triggered the same chemotaxis and chemokine signatures as was observed in the USP6high primary ES tumors ( Supplemental Figure 3B ) ."
33558334
USP6 affects robust CXCL10
| 1
USP6 activates robust CXCL10. 1 / 1
| 1
eidos
"It is highly likely that USP6 will be able to promote T cell recruitment and activation in vivo , given that USP6 induces robust production of CXCL10 , that CM from USP6-expressing ES cells can stimulate migration of primary T lymphocytes , and that ES cells expressing USP6 can induce APC activation in vivo ( as monitored by CD86 and MHCII surface upregulation ) ."
33558334
USP6 affects reporter
| 1
USP6 activates reporter. 1 / 1
| 1
eidos
"USP6 + IFNgamma cooperatively activated this reporter in transiently transfected HeLa cells , although the effects were much less pronounced than the dramatic synergy observed with endogenous CXCL10 ( Figure 2C ) ."
33558334
USP6 affects repair
| 1
USP6 activates repair. 1 / 1
| 1
eidos
"USP6 depletion caused cell cycle arrest and a deficiency in CDD repair mediated through instability of poly ( ADP-ribose ) polymerase-1 ( PARP-1 ) protein ."
30851349
USP6 affects reach maximum tumor
| 1
USP6 activates reach maximum tumor. 1 / 1
| 1
eidos
"USP6 prolonged the time to reach maximum tumor volume ( 2000 mm3 ) ( Figure 5B ) , with two `` strong responders '' in the + dox cohort failing to reach this endpoint ( labeled with asterisks in Figure 5A ) ."
33558334
USP6 affects rTSH beta promoter
| 1
USP6 inhibits rTSH beta promoter. 1 / 1
| 1
reach
"Expression of this mutant plasmid, pDeltaMTV (-15/+ l) LUC, was unresponsive to both unliganded receptors and RA treatment, suggesting that the +1 to +9 sequence contained a binding site for a retinoi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9296372
USP6 affects polyA site
| 1
USP6 activates polyA site. 1 / 1
| 1
reach
"The sole component of subcomplex CF1B, Hrp1, binds to the efficiency element and interacts with Rna14 and Rna15 to direct selection of the polyA site."
28138513
USP6 activates paracrine signaling. 1 / 1
| 1
reach
"In ABC, both neoplastic cells and other cells in the microenvironment exhibited P-STAT3 activation (XREF_FIG, left), suggesting that USP6 might induce paracrine signaling (as was confirmed below)."
27440725
USP6 affects oncogenic UBP6 protein
| 1
USP6 activates oncogenic UBP6 protein. 1 / 1
| 1
reach
"In all five cases of UBP6 linked human cancers referred to above, it remains unclear whether the heterologous promoters cause overexpression of normal, full-length UBP6 protein, or whether there have been further mutations, deletions, or alternate splicing within USP6 to produce an altered, oncogenic UBP6 protein."
19007433
reach
"For example, HRP1 and CLP1, both induced in response to MMS, are subunits of cleavage factor I, required for the cleavage and polyadenylation of 3 ' mRNA ends [XREF_BIBR]."
17140446
USP6 affects matrix metalloproteinase
| 1
USP6 activates matrix metalloproteinase. 1 / 1
| 1
eidos
"The increased expression of USP6 leads to the activation of the receptor activator of nuclear factor kappa B ( NF-kappaB ) ( RANK ) signaling pathway and the increased production of matrix metalloproteinase ( 4 , 5 ) ."
34335473
USP6 affects matrix metalloproteinase MMP
| 1
USP6 activates matrix metalloproteinase MMP. 1 / 1
| 1
eidos
"USP6 was found to induce matrix metalloproteinase ( MMP ) production via activation of nuclear factor kappaB [ 16 ] ."
33204561
USP6 affects killer
| 1
USP6 activates killer. 1 / 1
| 1
reach
"USP6 expressing ES cells stimulated migration of primary human monocytes and T lymphocytes and triggered activation of natural killer (NK) cells in vitro."
33558334
USP6 affects intratumoral activation NK cells
| 1
USP6 activates intratumoral activation NK cells. 1 / 1
| 1
eidos
"USP6 expression in ES stimulates NK cell activation and enhanced paracrine induction of chemokines The studies above demonstrate that USP6 is sufficient to increase intratumoral levels and activation of NK cells in vivo ."
33558334
USP6 affects intratumoral abundance NK cells
| 1
USP6 activates intratumoral abundance NK cells. 1 / 1
| 1
eidos
"USP6 increased not only the intratumoral abundance of NK cells ( Figure 6A and Supplemental Figure 13 ) , but also their activation and proliferative potential ( as monitored by CD69 and CD25 / IL2Ralpha , respectively ) ( Figure 6A and Supplemental Figure 14 ) ."
33558334
USP6 affects intra-tumoral abundance macrophages F4 DCs CD11c myeloid cells
| 1
USP6 activates intra-tumoral abundance macrophages F4 DCs CD11c myeloid cells. 1 / 1
| 1
eidos
"Analysis of lineage markers revealed that USP6 increased intra-tumoral abundance of macrophages ( F4 / 80 + ) , DCs ( CD11c + ) , and myeloid cells ( CD11b + ) , but not monocytes ( Ly6c + ) or granulocytes ( Ly6g + ) ( Figure 4D , and Supplemental Figures 7/8 for gating strategy ) ."
33558334
USP6 affects intra-tumoral abundance activated macrophages
| 1
USP6 activates intra-tumoral abundance activated macrophages. 1 / 1
| 1
eidos
"USP6 increases the intra-tumoral abundance of activated macrophages / DCs and NK cells in mice ."
33558334
USP6 affects infiltration anti-tumorigenic immune lineages
| 1
USP6 activates infiltration anti-tumorigenic immune lineages. 1 / 1
| 1
eidos
"However , USP6 simultaneously triggers IFN signaling ( 17 ) and infiltration of anti-tumorigenic immune lineages , which ultimately prevail to drive the spontaneous regression that typifies NF ."
33558334
USP6 affects immune subsets
| 1
USP6 activates immune subsets. 1 / 1
| 1
eidos
"Forthcoming studies will dissect how immune subsets are activated by USP6 , and assess their contribution to tumor suppression ."
33558334
USP6 affects immune infiltration
| 1
USP6 activates immune infiltration. 1 / 1
| 1
eidos
"Nevertheless , taken together these results suggest that in ES patients , as in our xenograft model , USP6 stimulates immune infiltration and suppresses cancer growth ."
33558334
USP6 affects hrp1
| 1
USP6 binds HDGFL2 and hrp1. 1 / 1
| 1
sparser
"From initial characterization and genomic distribution, the Ysc, Chlamydiales, SPI-1, and SPI-2 families were associated with animal–bacterial interactions while the Rhizobiales, Hrp1, and Hrp2 families were associated with plant–bacterial interactions."
24575107
USP6 affects hot tumor microenvironment
| 1
USP6 activates hot tumor microenvironment. 1 / 1
| 1
eidos
"This further raises the possibility that USP6 activity may be harnessed to create a `` hot '' tumor microenvironment in immunotherapy ."
33558334
USP6 affects high-LET protons
| 1
USP6 inhibits high-LET protons. 1 / 1
| 1
reach
"Using high-LET protons (Fig. 1C; Fig. E1B, available online at https://doi.org/10.1016/j.ijrobp.2019.02.053), depletion of USP6 (plus CYLD, USP7, USP31, and USP9X) also reduced cell survival by >40%."
30851349
USP6 affects growth RD-ES xenografts
| 1
USP6 inhibits growth RD-ES xenografts. 1 / 1
| 1
eidos
"USP6 inhibited growth of RD-ES xenografts in a dose-dependent manner ( Figure 4A ) ."
33558334
USP6 affects gold atom
| 1
reach
"Hrp1, the yeast CFIB and the counterpart of HLP1, binds AU rich EE and regulates correct positioning of the cleavage site and 3 '-end formation of pre-mRNAs XREF_BIBR, XREF_BIBR, XREF_BIBR."
26099751
USP6 affects glycoprotein
| 1
USP6 increases the amount of glycoprotein. 1 / 1
| 1
reach
"Here, we show that increased expression of TRE17 enhances invasiveness of the human sarcoma cell line HT-1080 by elevating the cell surface levels of the membrane glycoprotein CD147, which plays a central role in tumor progression."
35926707
USP6 affects glucose
| 1
USP6 activates glucose. 1 / 1
| 1
reach
"Two members of the tre-2 and USP6, BUB2, cdc16 (TBC1) domain family of proteins, Akt substrate of 160 kDa (also known as AS160 or TBC1D4) and TBC1D1, have been proposed as potential sites for the convergence of insulin and exercise signaling to stimulate glucose transport in skeletal muscle."
19955868
USP6 affects function resulting mouse cognitive
| 1
USP6 activates function resulting mouse cognitive. 1 / 1
| 1
eidos
"By generating a humanized knock-in ( KI ) mouse expressing USP6 under the control of Ca2 + / calmodulin-dependent kinase II ( CamkII ) promoter , the authors found that USP6 stabilizes NMDARs at synapses and enhances synaptic function resulting in improved mouse cognitive abilities ."
32719102
USP6 affects expression
| 1
USP6 inhibits expression. 1 / 1
| 1
sparser
"TRE17 simultaneously inhibits the expression of BMP-4 while augmenting the BMP antagonist, Gremlin-1."
20864534
USP6 affects efficiency CDD repair Fig. 4A compare blue yellow bars Fig. 4B repair
| 1
USP6 activates efficiency CDD repair Fig. 4A compare blue yellow bars Fig. 4B repair. 1 / 1
| 1
eidos
"USP6 controls CDD repair and cell cycle progression after high-LET protons Using an enzyme-modified neutral comet assay after high-LET protons , we found that depletion of USP6 significantly reduces the efficiency of CDD repair ( Fig. 4A [ compare blue and yellow bars ] and Fig. 4B ) , but not DSB repair , in comparison to NT control siRNA treated cells ( Fig. 4A [ compare green and red bars ] and Fig. 4C ) ."
30851349
USP6 affects contributing TRE2
| 1
USP6 activates contributing TRE2. 1 / 1
| 1
eidos
"In black males , the expressions of TRE1-1 , TRE1-2 and TRE1-3 were higher and increased TRE1 activity , while expressions of both TRE2 genes increased contributing to TRE2 activity ( Figs 4 and 5D ) ."
32191747
USP6 affects cidB
| 1
USP6 inhibits cidB. 1 / 1
| 1
reach
"Plasmids with SRP1, RTT103, HRP1, or FET4 alone suppressed cidB -induced toxicity (Figure 2b,c); FET4 was the only gene on the weakly suppressing YGPM32b05 plasmid, so it was not subcloned further (Figure 2a)."
31774393
USP6 inhibits chromatin remodeling. 1 / 1
| 1
reach
"In contrast, cohesin mutants rad21 and psc3 were rescued by loss of the RNA elimination pathway (Erh1, Mmi1, and Red1), and loader mutant mis4 was rescued by loss of Hrp1 mediated chromatin remodeling."
31072933
USP6 affects chemokine signatures
| 1
USP6 activates chemokine signatures. 1 / 1
| 1
eidos
"In the patient-derived ES cell line RD-ES , upon addition of dox , USP6 triggered the same chemotaxis and chemokine signatures as was observed in the USP6high primary ES tumors ( Supplemental Figure 3B ) ."
33558334
USP6 affects cellular response IFNs
| 1
USP6 activates cellular response IFNs. 1 / 1
| 1
eidos
"Together , these data suggest that USP6 serves to fine tune and amplify the cellular response to IFNs , and that it could play a pivotal role in modulating the immune TME through production of chemokines ."
33558334
USP6 affects cell
| 1
USP6 activates cell. 1 / 1
| 1
eidos
"In both lineages , USP6 induced a marked increase in the percentage of cells that were single and double positive for CD86 and MHCII ( Figure 5F , and Supplemental Figures 10-12 ) ."
33558334
USP6 activates cell population proliferation. 1 / 1
| 1
reach
"Tre2 (USP6NL) promotes colorectal cancer cell proliferation via Wnt and beta-catenin pathway."
31015802
USP6 affects cell migration
| 1
USP6 activates cell migration. 1 / 1
| 1
reach
"USP6 and TRE17 was shown to induce cell migration in the TRE17-RhoA and ROCK or IKK-NF-kappaB-MMP-9 signaling pathway."
28279784
USP6 affects cell cycle arrest
| 1
reach
"USP6 depletion caused cell cycle arrest and a deficiency in CDD repair mediated through instability of poly(ADP-ribose) polymerase-1 (PARP-1) protein."
30851349
USP6 affects cas9
| 1
USP6 activates cas9. 1 / 1
| 1
sparser
"Studies have used the TRE3G (Tet-On-3G) and TRE2 Tet-On promoters to activate Cas9 proteins in an animal model and human immortalised cell lines respectively under the control of administered doxycycline [ xref , xref ]."
32198625
USP6 affects carbon monoxide
| 1
USP6 activates carbon monoxide. 1 / 1
| 1
reach
"The expression levels of TPS and TRE2 were up-regulated by hypoxia/hypercapnia and dsILP2 combination, with the increase of CO 2 concentration, other trehalase genes begin to respond successively."
35514356
USP6 affects cancer growth
| 1
USP6 inhibits cancer growth. 1 / 1
| 1
eidos
"Nevertheless , taken together these results suggest that in ES patients , as in our xenograft model , USP6 stimulates immune infiltration and suppresses cancer growth ."
33558334
USP6 affects cadmium(2+)
| 1
Cadmium(2+) binds USP6. 1 / 1
| 1
reach
"Finally, the CD spectra of RNA and PNA1 bound to HRP1 were fully consistent with previous results on PNA-DNA triple helices."
20527745
USP6 affects anti-tumor immune response
| 1
USP6 activates anti-tumor immune response. 1 / 1
| 1
eidos
"Nevertheless , despite using a cross-species immunocompromised model , USP6 was able to elicit an anti-tumor immune response ."
33558334
USP6 affects air1/2 growth
| 1
USP6 inhibits air1/2 growth. 1 / 1
| 1
reach
"NAB and hnRNP genes, NPL3 and NAB1, HRP1 and NAB4, PUB1 or NAB2 do not suppress air1/2 growth (XREF_SUPPLEMENTARY), indicating that air1/2 suppression is specific to NAB3 and that Nab3 possesses a unique function, as compared to other RNA binding proteins."
25775092
USP6 affects activation receptor activator nuclear kappa B
| 1
USP6 activates activation receptor activator nuclear kappa B. 1 / 1
| 1
eidos
"The increased expression of USP6 leads to the activation of the receptor activator of nuclear factor kappa B ( NF-kappaB ) ( RANK ) signaling pathway and the increased production of matrix metalloproteinase ( 4 , 5 ) ."
34335473
USP6 affects activation T cells
| 1
USP6 activates activation T cells. 1 / 1
| 1
eidos
"USP6 expression in ES can also directly enhance NK cell activation , and we predict that USP6 would also promote activation of T cells in vivo due to their ability to stimulate their migration as well as activate APCs in the TME ."
33558334
USP6 affects abacavir
| 1
USP6 activates abacavir. 1 / 1
| 1
reach
"It also illustrates the added value of genomic analyses in the setting of an ABC lesion : complex clonal aberrations argues for a lesion secondary to a malignant proliferation whereas USP6 rearrangement allows the diagnosis of primary ABC."
29182118
USP6 affects Ypt
| 1
USP6 activates Ypt. 1 / 1
| 1
reach
"The product of the human Tre2 oncogene is structurally related to the Ypt and Rab GTPase activating proteins (Ypt and Rab GAPs)."
16099424
USP6 affects VDR
| 1
USP6 binds VDR. 1 / 1
| 1
sparser
"Aneurysmal bone cyst with an unusual clinical presentation and a novel VDR-USP6 fusion."
34369017
USP6 affects USP46
| 1
USP6 binds USP46 and DTL. 1 / 1
| 1
sparser
"Moreover, miR-3680-5p was associated with the USP6 , USP32 , USP46 , and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system."
28152049
USP6 affects USP32
1 |
USP6 binds USP32. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP6 affects Tax
| 1
USP6 binds Tax. 1 / 1
| 1
reach
"Tax can also bind TRE-2 in the LTR, which is located central and proximal to TRE-1."
21994774
USP6 affects TPM4
| 1
TPM4 binds USP6. 1 / 1
| 1
sparser
"Cutaneous Nodular Fasciitis with Rare TPM4-USP6 Fusion."
34643284
USP6 affects TNFSF10
| 1
USP6 activates TNFSF10. 1 / 1
| 1
reach
"Finally, apoptosis is mediated through the pro apoptotic ligand TRAIL, which is synergistically induced by Type I IFN and USP6."
30131449
USP6 affects TFRC
| 1
TFRC binds USP6. 1 / 1
| 1
reach
"That is, TR also bound predominantly to the TRE2 in the tail of premetamorphic tadpoles treated with or without T3 for 2days."
22800560
USP6 affects T cell recruitment
| 1
USP6 activates T cell recruitment. 1 / 1
| 1
eidos
"It is highly likely that USP6 will be able to promote T cell recruitment and activation in vivo , given that USP6 induces robust production of CXCL10 , that CM from USP6-expressing ES cells can stimulate migration of primary T lymphocytes , and that ES cells expressing USP6 can induce APC activation in vivo ( as monitored by CD86 and MHCII surface upregulation ) ."
33558334
USP6 affects Swm1/2 complex
| 1
USP6 binds Swm1/2 complex. 1 / 1
| 1
reach
"Previously, Nicolas et al (2006) XREF_BIBR showed that the Swm1/2 complex physically interacts with Hrp1."
17440621
USP6 affects Swm
| 1
USP6 binds Swm. 1 / 1
| 1
reach
"Because Hrp1 and Hrp3 co-purify we speculate that Hrp1 and Swm complex interactions might target some Swm complexes to perform demethylation through the interaction with Hrp3."
17440621
USP6 affects Smf2p
| 1
USP6 inhibits Smf2p. 1 / 1
| 1
reach
"XREF_BIBR Deletion of both TRE1 and TRE2 prevents the degradation of Smf1p and Smf2p, increasing manganese uptake and cadmium sensitivity much like a bsd2Delta mutant."
19705825
USP6 affects Smf1p
| 1
USP6 inhibits Smf1p. 1 / 1
| 1
reach
"XREF_BIBR Deletion of both TRE1 and TRE2 prevents the degradation of Smf1p and Smf2p, increasing manganese uptake and cadmium sensitivity much like a bsd2Delta mutant."
19705825
USP6 affects SR45A
| 1
USP6 binds tra and SR45A. 1 / 1
| 1
sparser
"Tra and Tre2 Interactions with RS 5~ ~o4~ j V. Proteins In Vitro Tra Tra2 Purified proteins derived from expression in insect cells (Tra2, Tra, and SF2) or bacteria (hnRNP A1) were sepa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8124712
USP6 affects SOX3
| 1
USP6 bound to TR/RXR activates SOX3. 1 / 1
| 1
reach
"In particular, one of them, TRE2 binds to TR/RXR heterodimers strongly in vitro and is required to mediate the activation of the Sox3 promoter by TR/RXR in the presence of T3 in reconstituted frog oocyte transcription system (XREF_FIG)."
27567710
USP6 affects SLC38A2
| 1
USP6 binds SLC38A2. 1 / 1
| 1
sparser
"Novel fusion partners were detected for 2 cases of solid aneurysmal bone cysts (PTBP1-USP6, SLC38A2-USP6)."
33147323
USP6 affects SETD2
| 1
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
USP6 affects RXR
| 1
RXR binds USP6. 1 / 1
| 1
reach
"To determine if the strong binding of TRE2 to the TR/RXR heterodimer was sequence-specific, we mutated the putative TRE2 at the positions known to be important for binding to TR/RXR heterodimer (Figure 3B) and determined the effect in the mobility shift assay."
31585895
USP6 affects RHOA
| 1
USP6 activates RHOA. 1 / 1
| 1
sparser
"To determine whether RhoA was activated by TRE17, we performed pulldown assays using the Rho-binding domain (RBD) of Rhotekin (which binds to RhoA in a GTP-dependent manner) as an affinity reagent."
20418905
USP6 affects RESULTS Chemokine
| 1
USP6 activates RESULTS Chemokine. 1 / 1
| 1
eidos
"RESULTS Chemokine production is associated with high USP6 expression in multiple human neoplasms in vivo , and is directly induced by USP6 in vitro We recently reported that USP6 is associated with an IFN response gene signature in primary patient samples of Ewing sarcoma ( ES ) , nodular fasciitis ( NF ) , and germ cell tumors ."
33558334
USP6 affects RBM5
| 1
USP6 binds RBM5. 1 / 1
| 1
sparser
"A USP6 fusion was identified in all 8 ABC, including a novel RBM5-USP6 fusion."
34089379
USP6 affects RAC1
1 |
USP6 binds RAC1. 1 / 1
1 |
biogrid
No evidence text available
12612085
USP6 affects RAB33B
1 |
USP6 binds RAB33B. 1 / 1
1 |
biogrid
No evidence text available
16923123
USP6 affects RAB
| 1
USP6 activates RAB. 1 / 1
| 1
reach
"The product of the human Tre2 oncogene is structurally related to the Ypt and Rab GTPase activating proteins (Ypt and Rab GAPs)."
16099424
USP6 affects PTBP1
| 1
USP6 binds PTBP1. 1 / 1
| 1
sparser
"Novel fusion partners were detected for 2 cases of solid aneurysmal bone cysts (PTBP1-USP6, SLC38A2-USP6)."
33147323
USP6 affects PE
| 1
USP6 activates PE. 1 / 1
| 1
reach
"In this study, HRP1 and PfEMP3 produced similar staining of PE in each of the stages observed and the results were the same for strain MC K+ and for clone FCR-3 K+."
8026748
USP6 affects PDIM
| 1
USP6 activates PDIM. 1 / 1
| 1
reach
"Using quantitative mass spectrometric analysis of total cell wall mycobacterial lipids [XREF_BIBR], we determined that in fact, both Tn : : Rv0712 and Tn : : hrp1 produced significantly less PDIM than wild-type H37Rv (XREF_FIG; XREF_SUPPLEMENTARY)."
28505176
USP6 affects PARP1
| 1
USP6 inhibits PARP1. 1 / 1
| 1
reach
"USP6 was competent to induce Erk activation and prevent PARP cleavage upon serum starvation, and this effect was abrogated by depletion of Jak1 or STAT3 (XREF_FIG)."
27440725
USP6 affects Osteosarcoma
| 1
USP6 inhibits Osteosarcoma. 1 / 1
| 1
reach
"Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619."
34571917
USP6 affects NT control siRNA cells
| 1
USP6 activates NT control siRNA cells. 1 / 1
| 1
eidos
"In contrast , absence of USP6 caused a significant decrease in cell survival versus NT control siRNA cells after high-LET alpha - particle irradiation ( Fig. 2B , 2D ) and high-LET protons ( Fig. 2F , 2H ) ."
30851349
USP6 affects NFKB1
1 |
USP6 activates NFKB1 bound to RELA. 1 / 1
1 |
signor
"These data confirm that tre17 activates nfkappab in a usp-dependent manner"
20418905
USP6 affects NEOPLASMS
| 1
USP6 binds NEOPLASMS. 1 / 1
| 1
trips
"USP6 -Associated Neoplasms: A Rapidly Expanding Family of Lesions."
32635781
USP6 affects NCOR1
| 1
USP6 binds NCOR1. 1 / 1
| 1
reach
"Very low binding of NCOR1 to TRE2 bound TRalpha1 was detected in euthyroid WT mice."
29273766
USP6 affects NAPSA
| 1
USP6 binds NAPSA. 1 / 1
| 1
reach
"Moving average plots show H2A.Z enrichment decreases with increasing Hrp1, Hrp3 and Nap1 binding at IGRs across the genome (XREF_FIG)."
19911051
USP6 affects NAB2
| 1
USP6 binds NAB2. 1 / 1
| 1
reach
"These experiments reveal that these interactions do not depend on the presence of RNA, as interactions between Caf1 and Hrp1 or Caf1 and Nab2 were not reduced following RNase treatment (XREF_FIG and data not shown)."
21464899
USP6 affects MUTYH
| 1
USP6 binds MUTYH. 1 / 1
| 1
sparser
"A clonal aberration (MYH-USP6 gene fusion) was reported only for NF, suggesting a benign neoplastic origin [ xref ]."
32140331
USP6 affects MMP
| 1
USP6 increases the amount of MMP. 1 / 1
| 1
reach
"Oliveira and colleagues studied the molecular pathogenesis underlying the role of USP6 in ABCs and showed that USP6 residing in the fibrous stromal component of ABC induces transcription of matrix metalloproteinase (MMP) through activation of the nuclear factor κB (NFκB), which seems to play a role in matrix degradation, angiogenesis, and inflammatory response."
32157177
USP6 affects MDFI
1 |
USP6 binds MDFI. 1 / 1
1 |
biogrid
No evidence text available
19060904
USP6 affects Leukemia
| 1
USP6 inhibits Leukemia. 1 / 1
| 1
reach
"USP6 overexpression significantly inhibited IM-induced apoptosis of leukemia cells."
35091542
USP6 affects KMT2D
| 1
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
USP6 affects KMT2B
| 1
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
USP6 affects Jak1 stabilization
| 1
USP6 activates Jak1 stabilization. 1 / 1
| 1
eidos
"We envisage that USP6 engenders a potent positive feed-forward immunostimulatory loop as follows ( model , Figure 7B ) : USP6 directly induces Jak1 stabilization / STAT1 activation , leading to low level chemokine production , which we speculate stimulates recruitment of myeloid , NK , and T cells ; these factors may also enhance immune cell activation and proliferation ."
33558334
USP6 affects IGFALS
| 1
USP6 activates IGFALS. 1 / 1
| 1
reach
"The aggregation of the human homologs of HRP-1, hnRNP-A1, and hnRNP-A3 was recently discovered to cause multisystem proteinopathy and ALS and FTLD."
28076789
USP6 affects IFNGR1
| 1
USP6 activates IFNGR1. 1 / 1
| 1
reach
"USP6 synergistically enhanced chemokine production in response to exogenous IFN by inducing surface upregulation of IFNAR1 and IFNGR1."
33558334
USP6 affects IFNAR1
| 1
USP6 activates IFNAR1. 1 / 1
| 1
reach
"USP6 synergistically enhanced chemokine production in response to exogenous IFN by inducing surface upregulation of IFNAR1 and IFNGR1."
33558334
USP6 affects IFN signature
| 1
USP6 activates IFN signature. 1 / 1
| 1
eidos
"In addition , we recently reported that an IFN signature is triggered by USP6 in NF , both in primary patient samples and in our cellular model ( 17 ) ."
33558334
USP6 affects Histone_H4
| 1
USP6 leads to the deacetylation of Histone_H4. 1 / 1
| 1
reach
"Hence, these results suggested that that Hrp1 is important to prevent acetylation of histone H4 at the central core region of the centromere."
15908586
USP6 affects Histone
| 1
USP6 leads to the deacetylation of Histone. 1 / 1
| 1
reach
"One possibility is that Hrp1 may enhance histone deacetylation by modulating chromatin structure at the central core region."
18493607
USP6 affects HMBS
| 1
USP6 binds HMBS, NMDAR, and NMDAR. 1 / 1
| 1
sparser
"USP6 interacts with NMDARs to attenuate UPS-mediated NMDAR turnover."
31841517
USP6 affects HIRA
| 1
USP6 inhibits HIRA. 1 / 1
| 1
reach
"XREF_BIBR At the hrp1 + locus loss of HIRA function resulted in marked changes to the MNase profile which extended throughout the entire gene and into the neighboring genes (atg12 + and pap1 +) (XREF_FIG; Fig."
25602522
USP6 affects HDGFL3
| 1
USP6 binds HDGFL3. 1 / 1
| 1
reach
"Moving average plots show H2A.Z enrichment decreases with increasing Hrp1, Hrp3 and Nap1 binding at IGRs across the genome (XREF_FIG)."
19911051
USP6 affects HDGFL2
| 1
USP6 binds HDGFL2 and hrp1. 1 / 1
| 1
sparser
"From initial characterization and genomic distribution, the Ysc, Chlamydiales, SPI-1, and SPI-2 families were associated with animal–bacterial interactions while the Rhizobiales, Hrp1, and Hrp2 families were associated with plant–bacterial interactions."
24575107
USP6 affects HDACs
| 1
USP6 activates HDACs. 1 / 1
| 1
reach
"We speculate that Hrp1 could promote the activity of these HDACs."
15908586
USP6 affects Glu-Ser
| 1
USP6 inhibits Glu-Ser. 1 / 1
| 1
reach
"USP6 inhibited ES xenograft growth in nude but not NSG mice and was accompanied by increased intra-tumoral chemokine production and infiltration and activation of NK cells, dendritic cells, and macrophages, consistent with a requirement for innate immune cells in mediating the anti-tumorigenic effects of USP6."
33558334
USP6 affects GREM1
| 1
Modified USP6 activates GREM1. 1 / 1
| 1
reach
"In particular, USP6 overexpression inhibits the expression of bone morphogenetic protein BMP4, a key regulator of osteogenesis, and simultaneously augments expression the BMP antagonist Gremlin-1 [53][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23769422
USP6 affects GATA1
| 1
USP6 increases the amount of GATA1. 1 / 1
| 1
reach
"These results indicate that TRE2, via T3-TRalpha1, mediates the positive regulation of the Gata1 gene transcription."
28910278
USP6 affects GAP
| 1
GAP binds USP6. 1 / 1
| 1
sparser
"In order to identify proteins that interact with the GAP domain of USP6 a yeast 2-hybrid screen was done with two cDNA libraries from human tissues (skeletal muscle and placenta)."
18687060
USP6 affects Fzds
| 1
USP6 activates Fzds. 1 / 1
| 1
reach
"Contrary to RNF43, ubiquitin specific protease 6 (USP6) is a deubiquitylase; ectopic expression of USP6 increases cell surface abundance of Fzds and Lrp6 and activates beta-catenin pathway in tumor cells XREF_BIBR."
32998794
USP6 affects Firefly
| 1
USP6 activates Firefly. 1 / 1
| 1
reach
"(C) HeLa Tet-Off cells (Clontech) were co-transfected with tetracycline response element (TRE2) promoter-driven Firefly (FF-luc) and Renilla (Renilla) luciferase reporters and the indicated GFP-fusion protein expression constructs."
26849127
USP6 affects FZD
| 1
USP6 ubiquitinates FZD. 1 / 1
| 1
reach
"USP6 overexpression resulted in an increased level of Fz, and ubiquitination of Fz decreased with increased USP6 expression [XREF_BIBR]."
32486158
USP6 affects FF-luc
| 1
USP6 activates FF-luc. 1 / 1
| 1
reach
"(C) HeLa Tet-Off cells (Clontech) were co-transfected with tetracycline response element (TRE2) promoter-driven Firefly (FF-luc) and Renilla (Renilla) luciferase reporters and the indicated GFP-fusion protein expression constructs."
26849127
USP6 affects FAT1
| 1
USP6 binds FAT1. 1 / 1
| 1
sparser
"Histopathology displayed predominantly solid morphology, and next generation sequencing (NGS) revealed a FAT1-USP6 gene fusion in the temporal lesion, and a MIR22HG-USP6 gene fusion in the maxillofacial lesion, the latter of which was not identified on fluorescence in situ hybridization (FISH)."
35102523
USP6 affects EXOSC8
1 |
USP6 binds EXOSC8. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP6 affects ES xenograft growth
| 1
USP6 inhibits ES xenograft growth. 1 / 1
| 1
eidos
"USP6 inhibited ES xenograft growth in nude but not NSG mice and was accompanied by increased intra-tumoral chemokine production and infiltration and activation of NK cells , dendritic cells , and macrophages , consistent with a requirement for innate immune cells in mediating the anti-tumorigenic effects of USP6 ."
33558334
USP6 affects ES xenograft growth concomitant intra-tumoral chemokine immune cell infiltration activation results
| 1
USP6 inhibits ES xenograft growth concomitant intra-tumoral chemokine immune cell infiltration activation results. 1 / 1
| 1
eidos
"USP6 inhibits ES xenograft growth concomitant with enhanced intra-tumoral chemokine production and immune cell infiltration and activation These results prompted us to investigate USP6 's effects on ES tumor growth and the immune TME ."
33558334
USP6 affects ES tumor growth xenografted nude mice
| 1
USP6 inhibits ES tumor growth xenografted nude mice. 1 / 1
| 1
eidos
"Furthermore , USP6 inhibited ES tumor growth in xenografted nude mice , coincident with increased intra-tumoral chemokine production , and immune cell infiltration and activation ."
33558334
USP6 affects ERK
| 1
USP6 activates ERK. 1 / 1
| 1
reach
"USP6 was competent to induce Erk activation and prevent PARP cleavage upon serum starvation, and this effect was abrogated by depletion of Jak1 or STAT3 (XREF_FIG)."
27440725
USP6 affects EPI64
| 1
USP6 binds ARF6 and EPI64. 1 / 1
| 1
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
USP6 affects EGFR
| 1
USP6 decreases the amount of EGFR. 1 / 1
| 1
reach
"USP6 was a target of miR-130a and the overexpression of miR-130a or inhibition of USP6 in UM MUM-2B and MUM-2C cell lines inhibited the expression of Wnt, β-catenin, and EGFR, and activated SMAD4 expression, while reducing UM cell migration and invasion abilities in vitro."
34522027
USP6 affects EEA1
| 1
BSG binds USP6, CD59, and EEA1. 1 / 1
| 1
sparser
"In infected cells overexpressing TRE17, both CD59 and CD147 were predominantly associated with EEA1 − /ARF6 + /TRE17 + membranes in HCMV infection [ xref and xref , (+)TRE17 panels]."
30042195
USP6 affects EE
| 1
USP6 binds EE. 1 / 1
| 1
reach
"The CPF subunits Cft1, Cft2 and Yth1 bind the U rich RNA sequences around the poly (A) site, Hrp1 binds to the EE and through association with CFIA helps tether Rna15 to the PE."
17151076
USP6 affects Deubiquitinase
| 1
USP6 activates Deubiquitinase. 1 / 1
| 1
reach
"We recently demonstrated using a DUB siRNA screen, that depletion of USP6 causes significantly increased radiosensitivity to high-LET IR (relatively high-LET protons and α-particles) but not low-LET IR (protons or X-rays), which was mediated by instability of PARP-1 required for CDD repair (7)."
34277417
USP6 affects DTL
| 1
USP6 binds USP46 and DTL. 1 / 1
| 1
sparser
"Moreover, miR-3680-5p was associated with the USP6 , USP32 , USP46 , and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system."
28152049
USP6 affects DNAJC24
| 1
USP6 binds DNAJC24. 1 / 1
| 1
sparser
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy 49 ) and the TRE17 oncogene 50 ."
21587297
USP6 affects D-GPNA1
| 1
USP6 binds D-GPNA1. 1 / 1
| 1
reach
"In accord with our previous study, 10 binding of D-GPNA1 to HRP1 hairpin made of deoxynucleotides (DNA version of HRP1) was weaker by about an order of magnitude (cf., entries 2 and 4)."
22146072
USP6 affects Cohesin
| 1
USP6 inhibits mutated Cohesin. 1 / 1
| 1
reach
"In contrast, cohesin mutants rad21 and psc3 were rescued by loss of the RNA elimination pathway (Erh1, Mmi1, and Red1), and loader mutant mis4 was rescued by loss of Hrp1 mediated chromatin remodeling."
31072933
USP6 affects CXCL9
| 1
USP6 inhibits CXCL9. 1 / 1
| 1
eidos
"CRISPR deletion of Jak1 or STAT1 , but not STAT3 , dramatically suppressed the synergistic induction of CXCL10 and CXCL9 by USP6 + IFNgamma ( Figure 2A ) ( 17 ) ) ."
33558334
USP6 affects CXCL9 CXCL10 CCL5
| 1
USP6 activates CXCL9 CXCL10 CCL5. 1 / 1
| 1
eidos
"RT-qPCR of tumors confirmed that USP6 induced expression of CXCL9 , CXCL10 , and CCL5 in vivo ( Figure 4C ) ."
33558334
USP6 affects CXCL10 CCL5
| 1
USP6 activates CXCL10 CCL5. 1 / 1
| 1
eidos
"At a 100-fold higher dose of IFNgamma ( 50 ng / ml ) , USP6 still enhanced CXCL10 and CCL5 expression more than 2 orders of magnitude ( Figure 1B ) ."
33558334
USP6 affects CUP1 reporter
| 1
Modified USP6 decreases the amount of CUP1 reporter. 1 / 1
| 1
reach
"We predicted that HRP1 overexpression would enhance attenuator recognition, reduce CUP1 reporter expression, and therefore increase copper sensitivity."
29686108
USP6 affects COL3A1
| 1
USP6 binds COL3A1. 1 / 1
| 1
sparser
"Next-generation sequencing revealed COL1A1-USP6 fusion in 2 tumors and COL3A1-USP6 fusion in the third tumor."
32583473
USP6 affects COL1A2
| 1
USP6 binds COL1A2. 1 / 1
| 1
sparser
"A cervical NF of a 14-month-old girl harbored the novel COL1A2-USP6 fusion."
33000481
USP6 affects CIE
| 1
USP6 activates CIE. 1 / 1
| 1
reach
"However, functional insights into the effects of TRE17-mediated CIE cargo trafficking on cell invasion remain unknown."
35926707
USP6 affects CIE cargo proteins
| 1
USP6 inhibits CIE cargo proteins. 1 / 1
| 1
reach
"We have previously demonstrated that TRE17 regulates the trafficking of plasma membrane proteins that enter cells via clathrin-independent endocytosis (CIE); TRE17 prevents CIE cargo proteins from being targeted to lysosomes for degradation by deubiquitylating them."
35926707
USP6 affects CFP82Q
| 1
USP6 binds CFP82Q. 1 / 1
| 1
reach
"Also tested was the interaction of CFP82Q and HRP1, a yeast protein involved in RNA processing that is glutamine rich, but does not include long homopolymeric glutamine repeats."
11511401
USP6 affects CENPA
| 1
USP6 activates CENPA. 1 / 1
| 1
reach
"The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres."
15908586
USP6 affects CDC42
1 |
USP6 binds CDC42. 1 / 1
1 |
biogrid
No evidence text available
12612085
USP6 affects CD59
| 1
BSG binds USP6, CD59, and EEA1. 1 / 1
| 1
sparser
"In infected cells overexpressing TRE17, both CD59 and CD147 were predominantly associated with EEA1 − /ARF6 + /TRE17 + membranes in HCMV infection [ xref and xref , (+)TRE17 panels]."
30042195
USP6 affects BMP4
| 1
Modified USP6 decreases the amount of BMP4. 1 / 1
| 1
reach
"In particular, USP6 overexpression inhibits the expression of bone morphogenetic protein BMP4, a key regulator of osteogenesis, and simultaneously augments expression the BMP antagonist Gremlin-1 [53][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23769422
USP6 affects BMP
| 1
Modified USP6 activates BMP. 1 / 1
| 1
reach
"In particular, USP6 overexpression inhibits the expression of bone morphogenetic protein BMP4, a key regulator of osteogenesis, and simultaneously augments expression the BMP antagonist Gremlin-1 [53][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23769422
USP6 affects Aneuploidy
1 |
Active USP6 inhibits Aneuploidy. 1 / 1
1 |
bel
"Similarly, the inactivation of the evolutionarily related DUB in yeast, Ubp6, increases the cellular fitness of aneuploid cells, which have been shown to incur increased proteotoxic stresses due to chromosomal imbalance [66]."
24457024
USP6 affects ARRB2
| 1
USP6 binds ARRB2. 1 / 1
| 1
reach
"In the model, HRP1 interacts and forms a complex with either beta-arrestin 1 (barr1) or beta-arrestin 2 (barr2)."
22735336
USP6 affects ARRB1
| 1
USP6 binds ARRB1. 1 / 1
| 1
reach
"In the model, HRP1 interacts and forms a complex with either beta-arrestin 1 (barr1) or beta-arrestin 2 (barr2)."
22735336
USP6 affects APP
1 |
USP6 binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
USP6 affects AP1S2
| 1
USP6 binds AP1S2. 1 / 1
| 1
sparser
"Given that USP6 is a hominoid-specific gene and disruption of USP6 gene expression by chromosomal translocation is associated with mental retardation [ xref ], USP6 may play a role in higher cognitive functions in humans."
31841517
USP6 affects AGK
| 1
USP6 increases the amount of AGK. 1 / 1
| 1
reach
"Furthermore, we performed a chromatin immunoprecipitation assay to further validate the binding of TEAD to the AGK promoter and found that YAP1/TEADs was able to bind to TRE1 in the AGK promoter, but not TRE2 to induce AGK transcription (Figure 5G,H, and Figure S1B).3.6 AGK inhibits the Hippo-YAP1 pathway and up-regulates TEAD transcriptional activity."
32827244
USP6 affects A0A288CFT1
1 |
USP6 binds A0A288CFT1. 1 / 1
1 |
virhostnet
No evidence text available
15708996
USP46 affects USP6
| 1
USP6 binds USP46 and DTL. 1 / 1
| 1
sparser
"Moreover, miR-3680-5p was associated with the USP6 , USP32 , USP46 , and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system."
28152049
USP32 affects USP6
1 |
USP6 binds USP32. 1 / 1
1 |
biogrid
No evidence text available
19615732
reach
"As many as 69% of primary ABCs demonstrate a characteristic clonal t(16;17) genetic translocation which can lead to an upregulation of the TRE17/USP6 oncogene [4]."
28580205
Tax affects USP6
| 1
USP6 binds Tax. 1 / 1
| 1
reach
"Tax can also bind TRE-2 in the LTR, which is located central and proximal to TRE-1."
21994774
TPM4 affects USP6
| 1
TPM4 binds USP6. 1 / 1
| 1
sparser
"Cutaneous Nodular Fasciitis with Rare TPM4-USP6 Fusion."
34643284
TGFB3 affects USP6
| 1
TGFB3 inhibits USP6. 1 / 1
| 1
reach
"MTT proliferation assays revealed that ERK pathway is partially implicated in TGFB3 reduced HRP-1 cell proliferation."
20926802
TFRC affects USP6
| 1
TFRC binds USP6. 1 / 1
| 1
reach
"That is, TR also bound predominantly to the TRE2 in the tail of premetamorphic tadpoles treated with or without T3 for 2days."
22800560
Swm1/2 complex affects USP6
| 1
USP6 binds Swm1/2 complex. 1 / 1
| 1
reach
"Previously, Nicolas et al (2006) XREF_BIBR showed that the Swm1/2 complex physically interacts with Hrp1."
17440621
Swm affects USP6
| 1
USP6 binds Swm. 1 / 1
| 1
reach
"Because Hrp1 and Hrp3 co-purify we speculate that Hrp1 and Swm complex interactions might target some Swm complexes to perform demethylation through the interaction with Hrp3."
17440621
Smoke affects USP6
1 |
Smoke increases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
21095227
STAT3 affects USP6
| 1
STAT3 activates USP6. 1 / 1
| 1
reach
"To test this, we examined STAT3 activation in USP6 and NIH3T3 cells in which NF-kappaB was inhibited through expression of IkappaB-alpha super repressor."
27440725
SR45A affects tra
| 1
USP6 binds tra and SR45A. 1 / 1
| 1
sparser
"Tra and Tre2 Interactions with RS 5~ ~o4~ j V. Proteins In Vitro Tra Tra2 Purified proteins derived from expression in insect cells (Tra2, Tra, and SF2) or bacteria (hnRNP A1) were sepa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8124712
SLC38A2 affects USP6
| 1
USP6 binds SLC38A2. 1 / 1
| 1
sparser
"Novel fusion partners were detected for 2 cases of solid aneurysmal bone cysts (PTBP1-USP6, SLC38A2-USP6)."
33147323
SETD2 affects USP9X
| 1
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
SA-miRNA gene affects USP6
| 1
SA-miRNA gene activates USP6. 1 / 1
| 1
reach
"Combinatorial regulation of SA-miRNA gene targets NAP1L1, SMARCD2 and USP6 by the miRNA from oncogenic MIR17HG and tumor-suppressive MIR100HG clusters."
28649425
RXR affects USP6
| 1
RXR binds USP6. 1 / 1
| 1
reach
"To determine if the strong binding of TRE2 to the TR/RXR heterodimer was sequence-specific, we mutated the putative TRE2 at the positions known to be important for binding to TR/RXR heterodimer (Figure 3B) and determined the effect in the mobility shift assay."
31585895
RELA affects USP6
| 1
IKK_complex binds USP6 and RELA. 1 / 1
| 1
sparser
"TRE17 associates with IKK and promotes its activation, leading to phosphorylation of p65 on S536."
22081069
RBM5 affects USP6
| 1
USP6 binds RBM5. 1 / 1
| 1
sparser
"A USP6 fusion was identified in all 8 ABC, including a novel RBM5-USP6 fusion."
34089379
RAB33B affects USP6
1 |
USP6 binds RAB33B. 1 / 1
1 |
biogrid
No evidence text available
16923123
Plant Extracts affects USP6
1 |
Plant Extracts increases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
23557933
Pf101 affects USP6
| 1
Pf101 activates USP6. 1 / 1
| 1
reach
"Phytoalexins were produced in bean after infiltration with Pt11528, Pt11528 : : Hrp1, Pt11528 cells treated with neomycin, or Pf101, but not in plants infiltrated with NPS3121 or water."
12271015
PTBP1 affects USP6
| 1
USP6 binds PTBP1. 1 / 1
| 1
sparser
"Novel fusion partners were detected for 2 cases of solid aneurysmal bone cysts (PTBP1-USP6, SLC38A2-USP6)."
33147323
PMS1 affects SETD2
| 1
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
PMS1 affects KRAS
| 1
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
PMS1 affects KMT2B
| 1
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
NMDAR affects HMBS
| 1
USP6 binds HMBS, NMDAR, and NMDAR. 1 / 1
| 1
sparser
"USP6 interacts with NMDARs to attenuate UPS-mediated NMDAR turnover."
31841517
NEOPLASMS affects USP6
| 1
USP6 binds NEOPLASMS. 1 / 1
| 1
trips
"USP6 -Associated Neoplasms: A Rapidly Expanding Family of Lesions."
32635781
NCOR1 affects USP6
| 1
USP6 binds NCOR1. 1 / 1
| 1
reach
"Very low binding of NCOR1 to TRE2 bound TRalpha1 was detected in euthyroid WT mice."
29273766
NAPSA affects USP6
| 1
USP6 binds NAPSA. 1 / 1
| 1
reach
"Moving average plots show H2A.Z enrichment decreases with increasing Hrp1, Hrp3 and Nap1 binding at IGRs across the genome (XREF_FIG)."
19911051
NAB2 affects USP6
| 1
USP6 binds NAB2. 1 / 1
| 1
reach
"These experiments reveal that these interactions do not depend on the presence of RNA, as interactions between Caf1 and Hrp1 or Caf1 and Nab2 were not reduced following RNase treatment (XREF_FIG and data not shown)."
21464899
MUTYH affects USP6
| 1
USP6 binds MUTYH. 1 / 1
| 1
sparser
"A clonal aberration (MYH-USP6 gene fusion) was reported only for NF, suggesting a benign neoplastic origin [ xref ]."
32140331
MDFI affects USP6
1 |
USP6 binds MDFI. 1 / 1
1 |
biogrid
No evidence text available
19060904
KRAS affects USP9X
| 1
USP6 binds USP9X, KRAS, KMT2D, and PMS1. 1 / 1
| 1
sparser
"Interestingly, we found that mutations in KRAS , FAM46C, KMT2D, PMS1 and USP6 were significantly associated with drug resistance."
30809292
KMT2B affects USP9X
| 1
USP6 binds USP9X, KMT2B, SETD2, and PMS1. 1 / 1
| 1
sparser
"Group 1 (LP1, OPM2, SKMM2, XG26, XG23, XG24, L363, XG1, XG16, XG12, and XG13) is mainly characterized by NRAS , CNOT3 and LRP1B mutated (MUT) and KRAS , MN1 , ATM , USP6 and KMT2B wild type (WT) genes; group 2 (XG25 and XG7) is associated with mutations in PMS1 , USP6 , SETD2 , KMT2B and FAM46C ; group 3 (RPMI, XG11, XG29, Lopra, XG27, MM1S, AMO1, XG20, and XG6) is mainly characterized by the presence of mutations in KRAS , ATM and MN1 as well as CNOT3 WT; group 4 (XG19, JJN3, XG2, and XG28) is characterized by KMT2B mutations; cell lines of group 5 (MOLP8, XG5, MOLP2, and XG30) were associated with mutations in MAP3K1 , EZH2 and SETD2 (Figure xref A)."
30809292
IKK_complex affects RELA, and USP6
| 1
IKK_complex binds USP6 and RELA. 1 / 1
| 1
sparser
"TRE17 associates with IKK and promotes its activation, leading to phosphorylation of p65 on S536."
22081069
Hypoxia affects USP6
| 1
Hypoxia increases the amount of USP6. 1 / 1
| 1
reach
"The expression levels of TPS and TRE2 were up-regulated by hypoxia/hypercapnia and dsILP2 combination, with the increase of CO 2 concentration, other trehalase genes begin to respond successively."
35514356
Hypercapnia affects USP6
| 1
Hypercapnia increases the amount of USP6. 1 / 1
| 1
reach
"The expression levels of TPS and TRE2 were up-regulated by hypoxia/hypercapnia and dsILP2 combination, with the increase of CO 2 concentration, other trehalase genes begin to respond successively."
35514356
HSPB3 affects USP6
| 1
HSPB3 activates USP6. 1 / 1
| 1
reach
"Previously, we demonstrated that silencing of cyclic AMP (cAMP) response element binding protein 3 like 1 (CREB3L1), a cellular transcription factor that inhibits HCV replication, allows HCV to replicate in HRP1 cells, a subclone of Huh-7 cells permissive for HCV replication."
23115279
HMBS affects USP6
| 1
USP6 binds HMBS, NMDAR, and NMDAR. 1 / 1
| 1
sparser
"USP6 interacts with NMDARs to attenuate UPS-mediated NMDAR turnover."
31841517
HDGFL3 affects USP6
| 1
USP6 binds HDGFL3. 1 / 1
| 1
reach
"Moving average plots show H2A.Z enrichment decreases with increasing Hrp1, Hrp3 and Nap1 binding at IGRs across the genome (XREF_FIG)."
19911051
HDGFL2 affects hrp1
| 1
USP6 binds HDGFL2 and hrp1. 1 / 1
| 1
sparser
"From initial characterization and genomic distribution, the Ysc, Chlamydiales, SPI-1, and SPI-2 families were associated with animal–bacterial interactions while the Rhizobiales, Hrp1, and Hrp2 families were associated with plant–bacterial interactions."
24575107
GAP affects USP6
| 1
GAP binds USP6. 1 / 1
| 1
sparser
"In order to identify proteins that interact with the GAP domain of USP6 a yeast 2-hybrid screen was done with two cDNA libraries from human tissues (skeletal muscle and placenta)."
18687060
FAT1 affects USP6
| 1
USP6 binds FAT1. 1 / 1
| 1
sparser
"Histopathology displayed predominantly solid morphology, and next generation sequencing (NGS) revealed a FAT1-USP6 gene fusion in the temporal lesion, and a MIR22HG-USP6 gene fusion in the maxillofacial lesion, the latter of which was not identified on fluorescence in situ hybridization (FISH)."
35102523
EXOSC8 affects USP6
1 |
USP6 binds EXOSC8. 1 / 1
1 |
biogrid
No evidence text available
25416956
EPI64 affects USP6
| 1
USP6 binds ARF6 and EPI64. 1 / 1
| 1
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
EGF affects USP6
1 |
EGF increases the amount of USP6. 1 / 1
1 |
bel
"Furthermore, the subcellular localization of TRE17 was dramatically regulated by these GTPases and mitogens. Under serum-starved conditions, TRE17 localized predominantly to filamentous structures within the cell. Epidermal growth factor (EGF) induced relocalization of TRE17 to the plasma membrane in a Cdc42-/Rac1-dependent manner."
12612085
EEA1 affects USP6
| 1
BSG binds USP6, CD59, and EEA1. 1 / 1
| 1
sparser
"In infected cells overexpressing TRE17, both CD59 and CD147 were predominantly associated with EEA1 − /ARF6 + /TRE17 + membranes in HCMV infection [ xref and xref , (+)TRE17 panels]."
30042195
EE affects USP6
| 1
USP6 binds EE. 1 / 1
| 1
reach
"The CPF subunits Cft1, Cft2 and Yth1 bind the U rich RNA sequences around the poly (A) site, Hrp1 binds to the EE and through association with CFIA helps tether Rna15 to the PE."
17151076
DTL affects USP6
| 1
USP6 binds USP46 and DTL. 1 / 1
| 1
sparser
"Moreover, miR-3680-5p was associated with the USP6 , USP32 , USP46 , and DTL genes, which have roles in the ubiquitin (deubiquitin) proteolysis system."
28152049
DNAJC24 affects USP6
| 1
USP6 binds DNAJC24. 1 / 1
| 1
sparser
"ARF6•GDP binds both TBC1 domain family member 24 (TBC1D24; a protein mutated in familial infantile myoclonic epilepsy 49 ) and the TRE17 oncogene 50 ."
21587297
D-GPNA1 affects USP6
| 1
USP6 binds D-GPNA1. 1 / 1
| 1
reach
"In accord with our previous study, 10 binding of D-GPNA1 to HRP1 hairpin made of deoxynucleotides (DNA version of HRP1) was weaker by about an order of magnitude (cf., entries 2 and 4)."
22146072
CRISPR affects USP6
| 1
CRISPR inhibits USP6. 1 / 1
| 1
reach
"Quick et al. reported targeting JAK1 or STAT3 using CRISPR, which significantly reduced oncogene ubiquitin-specific protease 6 (USP6)/TRE17 in bone and soft tissue tumors, which indicates possibility of treatment of this type of malignancy by inhibition of JAK/STAT pathway (281)."
30109213
COL3A1 affects USP6
| 1
USP6 binds COL3A1. 1 / 1
| 1
sparser
"Next-generation sequencing revealed COL1A1-USP6 fusion in 2 tumors and COL3A1-USP6 fusion in the third tumor."
32583473
COL1A2 affects USP6
| 1
USP6 binds COL1A2. 1 / 1
| 1
sparser
"A cervical NF of a 14-month-old girl harbored the novel COL1A2-USP6 fusion."
33000481
CFP82Q affects USP6
| 1
USP6 binds CFP82Q. 1 / 1
| 1
reach
"Also tested was the interaction of CFP82Q and HRP1, a yeast protein involved in RNA processing that is glutamine rich, but does not include long homopolymeric glutamine repeats."
11511401
CD59 affects USP6
| 1
BSG binds USP6, CD59, and EEA1. 1 / 1
| 1
sparser
"In infected cells overexpressing TRE17, both CD59 and CD147 were predominantly associated with EEA1 − /ARF6 + /TRE17 + membranes in HCMV infection [ xref and xref , (+)TRE17 panels]."
30042195
ARRB2 affects USP6
| 1
USP6 binds ARRB2. 1 / 1
| 1
reach
"In the model, HRP1 interacts and forms a complex with either beta-arrestin 1 (barr1) or beta-arrestin 2 (barr2)."
22735336
ARRB1 affects USP6
| 1
USP6 binds ARRB1. 1 / 1
| 1
reach
"In the model, HRP1 interacts and forms a complex with either beta-arrestin 1 (barr1) or beta-arrestin 2 (barr2)."
22735336
ARF6 affects EPI64, and USP6
| 1
USP6 binds ARF6 and EPI64. 1 / 1
| 1
sparser
"Collectively, these results indicate that, unlike the TBC domain of TRE17 , which preferentially binds Arf6-GDP ( xref ), the TBC domain of EPI64 specifically binds Arf6-GTP."
17145964
APP affects USP6
1 |
USP6 binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
AP1S2 affects USP6
| 1
USP6 binds AP1S2. 1 / 1
| 1
sparser
"Given that USP6 is a hominoid-specific gene and disruption of USP6 gene expression by chromosomal translocation is associated with mental retardation [ xref ], USP6 may play a role in higher cognitive functions in humans."
31841517
AKT affects USP6
| 1
AKT phosphorylates USP6. 1 / 1
| 1
reach
"In rodent skeletal muscle, Akt phosphorylates the Akt substrate of 160 kDa (AS160; also known as TBC1D4) and its paralog TBC1D1 (tre-2 and USP6, BUB2, cdc16 domain family member 1)."
25501433
A0A288CFT1 affects USP6
1 |
USP6 binds A0A288CFT1. 1 / 1
1 |
virhostnet
No evidence text available
15708996
3-isobutyl-1-methyl-7H-xanthine decreases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
28628672
4,4'-sulfonyldiphenol decreases the amount of USP6. 1 / 1
1 |
ctd
No evidence text available
28628672
3,3',5-triiodo-L-thyronine activates USP6. 1 / 1
| 1
reach
"That is, TR also bound predominantly to the TRE2 in the tail of premetamorphic tadpoles treated with or without T3 for 2days."
22800560