IndraLab

Statements

USP45 affects ERCC1
1 6 1 | 23 20
USP45 binds ERCC1.
6 | 6 20
USP45 binds ERCC1. 10 / 33
6 | 6 16
sparser
"Consistent with this notion, the DNA damage sensitivity of USP45 knockout cells is only rescued by wild-type USP45 and not by an active USP45 [Asp25Ala, Glu26Ala] mutant that is unable to bind ERCC1 (Fig xref C) or catalytically inactive USP45 [Cys199Ala] (Fig xref A)."
25538220
biogrid
No evidence text available
25538220
biogrid
No evidence text available
25538220
reach
"This observation, together with the findings that USP45 co-precipitates with XPF-ERCC1 in Slx4 null cells and that ERCC1 interacts with USP45 in a yeast two-hybrid assay, indicate that USP45 interacts directly with ERCC1."
25538220
reach
"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [55]."
27316462
sparser
"USP45 interacts with ERCC1."
25538220
sparser
"Another study [ xref ] demonstrated a direct interaction between the deubiquitylase USP45 and ERCC1, which may control its ubiquitylation."
30563071
sparser
"Importantly, we find that the USP45 mutant [Asp25Ala, Glu26Ala] that is catalytically active but that cannot bind to ERCC1 (Supplementary Fig S5A) failed to deubiquitylate ERCC1 in vitro , indicating that specific interaction between ERCC1 and USP45 is essential to trigger deubiquitylation."
25538220
reach
"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [XREF_BIBR]."
27316462
biogrid
No evidence text available
25538220
USP45 binds ERCC1 and ERCC4. 4 / 4
| 4
sparser
"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."
27827925
sparser
"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."
25538220
sparser
"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."
25538220
sparser
"USP45 associates with the ERCC1–XPF endonuclease."
25538220
USP45 deubiquitinates ERCC1.
1 1 | 13
USP45 deubiquitinates ERCC1. 10 / 12
1 | 11
reach
"It was shown that USP45 interacts with and deubiquitinates the excision repair cross complementation group 1 (ERCC1) subunit of the XPF-ERCC1 DNA repair nuclease which has role in the TC-NER of UV induced DNA damage [XREF_BIBR, XREF_BIBR]."
30831436
reach
"As expected, the catalytically inactive USP45 [Cys199Ala] mutant also failed to deubiquitylate ERCC1 (Fig XREF_FIG C, XREF_SUPPLEMENTARY)."
25538220
reach
"Upon UV exposure, USP45 interacts with ERCC1-XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that can not bind to ERCC1 failed to deubiquitinate ERCC1."
27827925
ubibrowser
"USP45 targeting ERCC1"
27316462
reach
"This, coupled with the report that inactivating the USP45 protein that deubiquitinates ERCC1 in human myelogenous leukaemia and osteosarcoma cells leads to reduced levels of NER and increased sensitivity to UV irradiation [XREF_BIBR], suggests that our therapeutic strategy is likely applicable to a wide range of human cancers."
28903417
reach
"Furthermore, USP45 can deubiquitylate ERCC1 in a manner that requires association of USP45 and ERCC1."
25538220
reach
"These data therefore indicate that likely the ubiquitylation of ERCC1, which is reversed by USP45, controls an aspect of ERCC1 function other than regulating its stability."
25538220
reach
"In this light, we observed that 5 other DUBs tested (AMSH, Cezanne, OTUB1, UCHL1 and USP27X) failed to deubiquitylate ERCC1 under conditions that wild-type USP45 deubiquitylated ERCC1 (Supplementary Fig S5C)."
25538220
reach
"The major role of ERCC1 deubiquitination by USP45 has been speculated to enable ERCC1-XPF to gain access to DNA damage sites."
27827925
reach
"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [55]."
27316462
Mutated USP45 deubiquitinates ERCC1. 2 / 2
| 2
reach
"Importantly, we find that the USP45 mutant [Asp25Ala, Glu26Ala] that is catalytically active but that can not bind to ERCC1 (Supplementary Fig S5A) failed to deubiquitylate ERCC1 in vitro, indicating that specific interaction between ERCC1 and USP45 is essential to trigger deubiquitylation."
25538220
reach
"Importantly, the USP45 mutant [Asp25Ala, Glu26Ala] that displays the same intrinsic catalytic activity as wild-type USP45 when assayed using a generic ubiquitin-rhodamine substrate (XREF_SUPPLEMENTARY), but that can not bind ERCC1, failed to deubiquitylate ERCC1 in parallel experiments (Fig XREF_FIG C, XREF_SUPPLEMENTARY)."
25538220
USP45 deubiquitinates ERCC1 on lysine. 1 / 1
1 |
biopax:reactome
No evidence text available
USP45 activates ERCC1.
| 3
USP45 activates ERCC1. 3 / 4
| 3
reach
"Moreover, expression of wild-type USP45, but not catalytically deficient USP45 [Cys199Ala] mutant in these cells, restored the number of spontaneous ERCC1 foci almost to the level seen in wild-type U2OS cells (Fig XREF_FIG A and B)."
25538220
reach
"USP45 targeting ERCC1."
27316462
reach
"Expression of wild-type USP45, but not the catalytically deficient USP45 [Cys199Ala] mutant in USP45 knockout U2OS cells, restored the number of DNA damage induced ERCC1 foci to levels observed in wild-type cells (Fig XREF_FIG A and B)."
25538220
USP45 inhibits ERCC1.
| 1
USP45 inhibits ERCC1. 1 / 2
| 1
reach
"Restoring expression of wild-type USP45 in knockout U2OS cells markedly lowered the high molecular weight species of ERCC1 (Fig XREF_FIG B)."
25538220
ERCC1 affects USP45
6 | 6 21
ERCC1 binds USP45.
6 | 6 20
USP45 binds ERCC1. 10 / 33
6 | 6 16
sparser
"Consistent with this notion, the DNA damage sensitivity of USP45 knockout cells is only rescued by wild-type USP45 and not by an active USP45 [Asp25Ala, Glu26Ala] mutant that is unable to bind ERCC1 (Fig xref C) or catalytically inactive USP45 [Cys199Ala] (Fig xref A)."
25538220
biogrid
No evidence text available
25538220
biogrid
No evidence text available
25538220
reach
"This observation, together with the findings that USP45 co-precipitates with XPF-ERCC1 in Slx4 null cells and that ERCC1 interacts with USP45 in a yeast two-hybrid assay, indicate that USP45 interacts directly with ERCC1."
25538220
reach
"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [55]."
27316462
sparser
"USP45 interacts with ERCC1."
25538220
sparser
"Another study [ xref ] demonstrated a direct interaction between the deubiquitylase USP45 and ERCC1, which may control its ubiquitylation."
30563071
sparser
"Importantly, we find that the USP45 mutant [Asp25Ala, Glu26Ala] that is catalytically active but that cannot bind to ERCC1 (Supplementary Fig S5A) failed to deubiquitylate ERCC1 in vitro , indicating that specific interaction between ERCC1 and USP45 is essential to trigger deubiquitylation."
25538220
reach
"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [XREF_BIBR]."
27316462
biogrid
No evidence text available
25538220
USP45 binds ERCC1 and ERCC4. 4 / 4
| 4
sparser
"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."
27827925
sparser
"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."
25538220
sparser
"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."
25538220
sparser
"USP45 associates with the ERCC1–XPF endonuclease."
25538220
ERCC1 ubiquitinates USP45.
| 1
ERCC1 ubiquitinates USP45. 1 / 1
| 1
sparser
"ERCC1 binds to the USP45 deubiquitylase, and ERCC1 ubiquitination was increased in USP45 knockout cells ( Perez-Oliva et al., 2015 )."
26074087
Peptide affects USP45
| 17
Peptide activates USP45. 10 / 17
| 17
reach
"To overcome this inconvenience, we then constructed a novel recombinant strain, L. lactis MG1363 harboring an expression plasmid pSECN, in which the n gene was fused with the coding sequence of USP45 signal peptide and was controlled by the constitutive L. lactis promoter P59."
15660214
reach
"Our data confirmed that the use of sp6 anchor in addition to usp45 signal peptide and interval sequence can efficiently display LTB on the surface of L. lactis."
34264362
reach
"shuttle vector: 1) L. lactis expressing secreted proteins was constructed with recombinant pTRKH2 (secreted-protein plasmid) carrying the Usp45 signal peptide (SPUsp45), nontoxic adjuvanted tetanus toxin fragment C (TETC), and 14 of the 38 C-terminal repeats (14CDTA) of nontoxic C. difficile toxin A (TcdA); and 2) L. lactis expressing secreted and membrane proteins was constructed with recombinant pTRKH2 (membrane-anchored plasmid) carrying SPUsp45, TETC, 14CDTA, and the cell wall-anchored sequence of protein M6 (cwaM6)."
23865596
reach
"P1 represents the constitutive promoter; SD, Shine-Dalgarno sequence; SS, first codons of the Usp45 signal peptide fused to the psaA gene."
16549380
reach
"P1 represents the constitutive promoter; SD, Shine-Dalgarno sequence; SS, first codons of the Usp45 signal peptide fused to the psaA gene.Fig."
16549380
reach
"The psaA gene was cloned into the pT1NX vector PstI site, which produced a fusion of a truncated usp45 signal peptide carried by the vector to the PsaA sequence (Fig. 1), under the control of a constitutive promoter."
16549380
reach
"To calculate the efficacy of hsTRAIL secretion, when pNZ8124 plasmid vector with sequence for usp45 leader peptide was used, we performed ELISA and quantified the concentration of the protein both in crude supernatants and cell lysates after 4 h upon the nisin-induction."
30446013
reach
"In early work in the field, Dieye et al. [27] showed that replacement of the M6 signal peptide with the Usp45 signal peptide from L. lactis doubled the amount of a staphylococcal nuclease reporter protein (NucA) that was successfully anchored to the cell wall [27] ."
27142045
reach
"A cassette consisting of USP45 fused with LEISSTCDA propeptide to increase secretion efficiency, pNZ8048 multiple cloning sites (MCS) modified to include more RE sites, pNZ8048 terminator (T), and TP901–1 bacteriophage attachment site (attP) was synthesized by Integrated DNA Technologies (Singapore) and denoted as attP cassette.The vectors constructions strategy was divided into four phases; Phase I) Construction of PZatt cassette composed of the P promoter, USP45 signal peptide, LEISSTCDA propeptide and attP sequence; Phase II) Construction of the secretion integrative vectors (pS1–4); (a) Plasmid circularisation by incorporation of erythromycin resistant gene and E. coli replication origin into the PZatt cassette, denoted as pS1; (b) Replacement of P promoter with P promoter to produce pS3 plasmid; (c) Replacement of USP45-LEISSTCDA fusion with SPK1 signal peptide into each pS1 and pS3 plasmids to produce pS2 and pS4 plasmids (Additional file 3: Figure S1); Phase III) Construction of the surface display integrative vectors (pSD1–4) by incorporation of PrtP anchor domain into each secretion integrative vector; Phase IV) Cloning of reporter gene, nuclease (Additional file 4: Figure S2)."
31775775
reach
"As for the surface display integrative vector, all systems developed were comparable with the exception of the combination of P 170 promoter with USP45 signal peptide which gave very low signals in whole cell ELISA."
31775775
USP45 affects SPDL1
| 6
USP45 binds SPDL1. 5 / 5
| 5
sparser
"This could be explained if the interaction is through the ubiquitin motif as data from the yeast two hybrid assay reveals that the interaction between USP45 and Spindly is not direct or could be through a third, unknown ubiquitylated protein in the complex."
30258100
sparser
"Given that USP45 is a DUB, we decided to explore the ubiquitylation in the Spindly-USP45 complex."
30258100
sparser
"To validate the data of mass spectrometry, co-immunoprecipitation assays were performed using endogenous USP45 followed by immunoblot that validated the interaction between endogenous Spindly and endogenous USP45 (Fig.  xref )."
30258100
sparser
"These results further underline the importance of DUB enzymatic activity in the interaction between USP45 and Spindly."
30258100
sparser
"In order to map the region of USP45 interacting with Spindly, we performed co-immunoprecipitation studies from HEK293 cells transiently expressing different USP45 fragments GFP tagged (Fig.  xref )."
30258100
USP45 binds SPDL1 and FlaG. 1 / 1
| 1
sparser
"This suggests that Spindly could be potentially be mono-ubiquitylated instead of poly-ubiquitylated: Treatment of the IP of Spindly-FLAG with recombinant USP45 WT showed a removal of the potential Spindly mono-ubiquitylation band (Fig.  xref , right panel)."
30258100
USP45 affects ERCC4
2 | 4
USP45 binds ERCC1 and ERCC4. 4 / 4
| 4
sparser
"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."
27827925
sparser
"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."
25538220
sparser
"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."
25538220
sparser
"USP45 associates with the ERCC1–XPF endonuclease."
25538220
USP45 binds ERCC4. 2 / 2
2 |
biogrid
No evidence text available
25538220
biogrid
No evidence text available
25538220
SPDL1 affects USP45
| 6
USP45 binds SPDL1. 5 / 5
| 5
sparser
"This could be explained if the interaction is through the ubiquitin motif as data from the yeast two hybrid assay reveals that the interaction between USP45 and Spindly is not direct or could be through a third, unknown ubiquitylated protein in the complex."
30258100
sparser
"Given that USP45 is a DUB, we decided to explore the ubiquitylation in the Spindly-USP45 complex."
30258100
sparser
"To validate the data of mass spectrometry, co-immunoprecipitation assays were performed using endogenous USP45 followed by immunoblot that validated the interaction between endogenous Spindly and endogenous USP45 (Fig.  xref )."
30258100
sparser
"These results further underline the importance of DUB enzymatic activity in the interaction between USP45 and Spindly."
30258100
sparser
"In order to map the region of USP45 interacting with Spindly, we performed co-immunoprecipitation studies from HEK293 cells transiently expressing different USP45 fragments GFP tagged (Fig.  xref )."
30258100
USP45 binds SPDL1 and FlaG. 1 / 1
| 1
sparser
"This suggests that Spindly could be potentially be mono-ubiquitylated instead of poly-ubiquitylated: Treatment of the IP of Spindly-FLAG with recombinant USP45 WT showed a removal of the potential Spindly mono-ubiquitylation band (Fig.  xref , right panel)."
30258100
ERCC4 affects USP45
2 | 4
USP45 binds ERCC1 and ERCC4. 4 / 4
| 4
sparser
"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."
27827925
sparser
"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."
25538220
sparser
"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."
25538220
sparser
"USP45 associates with the ERCC1–XPF endonuclease."
25538220
USP45 binds ERCC4. 2 / 2
2 |
biogrid
No evidence text available
25538220
biogrid
No evidence text available
25538220
Bisphenol A affects USP45
4 |
Bisphenol A methylates USP45.
1 |
Bisphenol A methylates USP45. 1 / 1
1 |
ctd
No evidence text available
28505145
Bisphenol A increases the amount of USP45.
1 |
Bisphenol A increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
25181051
Bisphenol A demethylates USP45.
1 |
Bisphenol A demethylates USP45. 1 / 1
1 |
ctd
No evidence text available
30906313
Bisphenol A decreases the amount of USP45.
1 |
Bisphenol A decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
30816183
USP45 affects SLX4
2 | 1
USP45 binds SLX4. 3 / 4
2 | 1
biogrid
No evidence text available
25538220
biogrid
No evidence text available
25538220
sparser
"In agreement with USP45 associating with SLX4 indirectly through its ability to bind ERCC1, we found that USP45 did not co-immunoprecipitate with SLX4 from ERCC1 knockout mouse embryonic fibroblasts (MEFs) (Fig xref D; McWhir et al , xref ; Melton et al , xref )."
25538220
ERCC4 affects ERCC1
| 4
USP45 binds ERCC1 and ERCC4. 4 / 4
| 4
sparser
"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."
27827925
sparser
"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."
25538220
sparser
"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."
25538220
sparser
"USP45 associates with the ERCC1–XPF endonuclease."
25538220
Valproic acid affects USP45
3 |
Valproic acid increases the amount of USP45.
2 |
Valproic acid increases the amount of USP45. 2 / 2
2 |
ctd
No evidence text available
29154799
ctd
No evidence text available
24935251
Valproic acid demethylates USP45.
1 |
Valproic acid demethylates USP45. 1 / 1
1 |
ctd
No evidence text available
29154799
USP45 affects SP
| 3
USP45 binds HSPD1 and SP. 3 / 3
| 3
sparser
"SP Usp45 ::GroEL might undergo rapid folding right after their synthesis, which interferes with (or hampers) the secretion process."
16556312
sparser
"Analysis of induced NZ(pSEC:groEL) samples revealed only one band in the C fraction, with an expected size of around 60 kDa, which corresponds to the GroEL precursor (SP Usp45 ::GroEL) (Figure 2 )."
16556312
sparser
"Similar results were obtained when pCYT and pSEC vectors were used to produce the B. abortus GroEL chaperone protein: only pSEC:GroEL plasmid was obtained and subsequently the fusion SP Usp45 :GroEL was detected in Western blot experiments (V. Azevedo, unpublished data)."
15631634
USP45 affects MYC
| 2 1
USP45 binds MYC.
| 1 1
USP45 binds MYC. 2 / 2
| 1 1
sparser
"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."
36765885
reach
"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."
36765885
USP45 activates MYC.
| 1
USP45 activates MYC. 1 / 1
| 1
reach
"Further, USP45 overexpressing can upregulate MYC, and this overexpressing can significantly enhance cancer development, cancer cell stemness and drug resistance."
36765885
USP45 affects HSPD1
| 3
USP45 binds HSPD1 and SP. 3 / 3
| 3
sparser
"SP Usp45 ::GroEL might undergo rapid folding right after their synthesis, which interferes with (or hampers) the secretion process."
16556312
sparser
"Analysis of induced NZ(pSEC:groEL) samples revealed only one band in the C fraction, with an expected size of around 60 kDa, which corresponds to the GroEL precursor (SP Usp45 ::GroEL) (Figure 2 )."
16556312
sparser
"Similar results were obtained when pCYT and pSEC vectors were used to produce the B. abortus GroEL chaperone protein: only pSEC:GroEL plasmid was obtained and subsequently the fusion SP Usp45 :GroEL was detected in Western blot experiments (V. Azevedo, unpublished data)."
15631634
USP45 affects FBXL7
| 1 1
FBXL7 binds USP45. 1 / 2
| 1
reach
"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12."
25654763
USP1 binds FBXL7 and USP45. 1 / 1
| 1
sparser
"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12. xref These deubiquitylation enzymes could counteract SCF Fbxl18 to remove ubiquitin from Fbxl7 to prevent its degradation."
25654763
SP affects USP45
| 3
USP45 binds HSPD1 and SP. 3 / 3
| 3
sparser
"SP Usp45 ::GroEL might undergo rapid folding right after their synthesis, which interferes with (or hampers) the secretion process."
16556312
sparser
"Analysis of induced NZ(pSEC:groEL) samples revealed only one band in the C fraction, with an expected size of around 60 kDa, which corresponds to the GroEL precursor (SP Usp45 ::GroEL) (Figure 2 )."
16556312
sparser
"Similar results were obtained when pCYT and pSEC vectors were used to produce the B. abortus GroEL chaperone protein: only pSEC:GroEL plasmid was obtained and subsequently the fusion SP Usp45 :GroEL was detected in Western blot experiments (V. Azevedo, unpublished data)."
15631634
MYC affects USP45
| 2 1
MYC binds USP45.
| 1 1
USP45 binds MYC. 2 / 2
| 1 1
sparser
"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."
36765885
reach
"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."
36765885
MYC inhibits USP45.
| 1
MYC inhibits USP45. 1 / 1
| 1
reach
"Interestingly, without enhancing cancer development, MYC silencing with shRNA can only suppress USP45-induced stemness and drug resistance."
36765885
HSPD1 affects USP45
| 3
USP45 binds HSPD1 and SP. 3 / 3
| 3
sparser
"SP Usp45 ::GroEL might undergo rapid folding right after their synthesis, which interferes with (or hampers) the secretion process."
16556312
sparser
"Analysis of induced NZ(pSEC:groEL) samples revealed only one band in the C fraction, with an expected size of around 60 kDa, which corresponds to the GroEL precursor (SP Usp45 ::GroEL) (Figure 2 )."
16556312
sparser
"Similar results were obtained when pCYT and pSEC vectors were used to produce the B. abortus GroEL chaperone protein: only pSEC:GroEL plasmid was obtained and subsequently the fusion SP Usp45 :GroEL was detected in Western blot experiments (V. Azevedo, unpublished data)."
15631634
FBXL7 affects USP45
| 1 1
FBXL7 binds USP45. 1 / 2
| 1
reach
"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12."
25654763
USP1 binds FBXL7 and USP45. 1 / 1
| 1
sparser
"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12. xref These deubiquitylation enzymes could counteract SCF Fbxl18 to remove ubiquitin from Fbxl7 to prevent its degradation."
25654763
Doxorubicin affects USP45
1 | 1
Doxorubicin inhibits USP45.
| 1
Doxorubicin inhibits USP45. 1 / 1
| 1
reach
"Since USP45 is significantly expressed in cervical tumors, we have discovered that the combination of α-mangostin and doxorubicin can significantly inhibit USP45-induced cervical tumorigenesis in an animal model."
36765885
Doxorubicin decreases the amount of USP45.
1 |
Doxorubicin decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
29803840
Aflatoxin B1 affects USP45
2 |
Aflatoxin B1 methylates USP45.
1 |
Aflatoxin B1 methylates USP45. 1 / 1
1 |
ctd
No evidence text available
30157460
Aflatoxin B1 increases the amount of USP45.
1 |
Aflatoxin B1 increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
19770486
ZFR affects USP45
2 |
ZFR binds USP45. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
25538220
USP45 affects response to drug
| 2
USP45 inhibits response to drug.
| 1
USP45 bound to natural small molecule inhibits response to drug. 1 / 1
| 1
reach
"Moreover, we have identified that USP45 can be specifically bound and inhibited by a natural small molecule (α-mangostin), in turn significantly suppressing USP45-induced stemness and drug resistance."
36765885
USP45 activates response to drug.
| 1
reach
"Suppression of Cancer Cell Stemness and Drug Resistance via MYC Destabilization by Deubiquitinase USP45 Inhibition with a Natural Small Molecule."
36765885
USP45 affects ZFR
2 |
ZFR binds USP45. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
25538220
USP45 affects RBMX
2 |
USP45 binds RBMX. 2 / 2
2 |
biogrid
No evidence text available
25538220
biogrid
No evidence text available
19615732
USP45 affects MYL12B
2 |
USP45 binds MYL12B. 2 / 2
2 |
biogrid
No evidence text available
25538220
biogrid
No evidence text available
19615732
USP45 affects MYH9
2 |
USP45 binds MYH9. 2 / 2
2 |
biogrid
No evidence text available
25538220
biogrid
No evidence text available
19615732
USP45 affects MYH10
2 |
USP45 binds MYH10. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
25538220
USP45 affects ERCC1-XPF
| 2
USP45 binds ERCC1-XPF. 2 / 2
| 2
reach
"USP45 interacts specifically with ERCC1-XPF via its N-terminal 61 residues."
25538220
reach
"Upon UV exposure, USP45 interacts with ERCC1-XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that can not bind to ERCC1 failed to deubiquitinate ERCC1."
27827925
RBMX affects USP45
2 |
USP45 binds RBMX. 2 / 2
2 |
biogrid
No evidence text available
25538220
biogrid
No evidence text available
19615732
MYL12B affects USP45
2 |
USP45 binds MYL12B. 2 / 2
2 |
biogrid
No evidence text available
25538220
biogrid
No evidence text available
19615732
MYH9 affects USP45
2 |
USP45 binds MYH9. 2 / 2
2 |
biogrid
No evidence text available
25538220
biogrid
No evidence text available
19615732
MYH10 affects USP45
2 |
USP45 binds MYH10. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
25538220
ERCC1-XPF affects USP45
| 2
USP45 binds ERCC1-XPF. 2 / 2
| 2
reach
"USP45 interacts specifically with ERCC1-XPF via its N-terminal 61 residues."
25538220
reach
"Upon UV exposure, USP45 interacts with ERCC1-XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that can not bind to ERCC1 failed to deubiquitinate ERCC1."
27827925
17alpha-ethynylestradiol increases the amount of USP45.
1 |
17alpha-ethynylestradiol increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
29097150
17alpha-ethynylestradiol decreases the amount of USP45.
1 |
17alpha-ethynylestradiol decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
23129252
Α-mangostin affects USP45
| 1
Α-mangostin inhibits USP45. 1 / 1
| 1
reach
"Since USP45 is significantly expressed in cervical tumors, we have discovered that the combination of α-mangostin and doxorubicin can significantly inhibit USP45-induced cervical tumorigenesis in an animal model."
36765885
Vorinostat affects USP45
1 |
Vorinostat increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
27188386
Vinclozolin affects USP45
1 |
Vinclozolin increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
23034163
ctd
No evidence text available
26179874
Trichostatin A affects USP45
1 |
Trichostatin A increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
24935251
Sunitinib affects USP45
1 |
Sunitinib increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
31533062
Pirinixic acid affects USP45
1 |
Pirinixic acid decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
18445702
Phorbol 13-acetate 12-myristate increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
25613284
Phlorizin affects USP45
1 |
Phlorizin decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
22538082
Paracetamol affects USP45
1 |
Paracetamol increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
26690555
Natural small molecule affects USP45
| 1
USP45 binds natural small molecule. 1 / 1
| 1
reach
"Moreover, we have identified that USP45 can be specifically bound and inhibited by a natural small molecule (α-mangostin), in turn significantly suppressing USP45-induced stemness and drug resistance."
36765885
Mono(2-ethylhexyl) phthalate decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
31059758
Mitomycin C affects USP45
| 1
Mitomycin C activates USP45. 1 / 1
| 1
reach
"We also explored how USP45 knockout impacts on gamma-H2AX foci induced by MMC."
25538220
Methylmercury chloride decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
28001369
Methyl methanesulfonate increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
23649840
Methapyrilene affects USP45
1 |
Methapyrilene methylates USP45. 1 / 1
1 |
ctd
No evidence text available
30157460
Manganese(II) chloride decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
17175027
Manganese atom affects USP45
1 |
Manganese atom decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
17175027
Lactacystin affects USP45
| 1
Lactacystin inhibits USP45. 1 / 1
| 1
reach
"To explore whether USP45 can directly catalyse deubiquitylation of ERCC1, we isolated ubiquitylated Flag-ERCC1 (Fig XREF_FIG C) or GFP-ERCC1 (XREF_SUPPLEMENTARY), expressed in USP45 knockout U2OS cells treated with lactacystin proteasomal inhibitor."
25538220
Ionomycin affects USP45
1 |
Ionomycin increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
25613284
Hsa-miR-6873-5p affects USP45
1 |
Hsa-miR-6873-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6783-5p affects USP45
1 |
Hsa-miR-6783-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-665 affects USP45
1 |
Hsa-miR-665 decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-630 affects USP45
1 |
Hsa-miR-630 decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-526a affects USP45
1 |
Hsa-miR-526a decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-523-5p affects USP45
1 |
Hsa-miR-523-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-522-5p affects USP45
1 |
Hsa-miR-522-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-520g-5p affects USP45
1 |
Hsa-miR-520g-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-520c-5p affects USP45
1 |
Hsa-miR-520c-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519c-5p affects USP45
1 |
Hsa-miR-519c-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519b-5p affects USP45
1 |
Hsa-miR-519b-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519a-5p affects USP45
1 |
Hsa-miR-519a-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-518f-5p affects USP45
1 |
Hsa-miR-518f-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-518e-5p affects USP45
1 |
Hsa-miR-518e-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-518d-5p affects USP45
1 |
Hsa-miR-518d-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4777-5p affects USP45
1 |
Hsa-miR-4777-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4668-5p affects USP45
1 |
Hsa-miR-4668-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3662 affects USP45
1 |
Hsa-miR-3662 decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-32-5p affects USP45
1 |
Hsa-miR-32-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3149 affects USP45
1 |
Hsa-miR-3149 decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3148 affects USP45
1 |
Hsa-miR-3148 decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3145-3p affects USP45
1 |
Hsa-miR-3145-3p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-192-5p affects USP45
1 |
Hsa-miR-192-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-let-7f-5p affects USP45
1 |
Hsa-let-7f-5p decreases the amount of USP45. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Galactose affects USP45
| 1
Galactose activates USP45. 1 / 1
| 1
sparser
"We also show that the usp45 promoter is highly activated by galactose."
32532874
Formaldehyde affects USP45
1 |
Formaldehyde decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
23649840
Folic acid affects USP45
1 |
Folic acid decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
20938992
Dioxygen affects USP45
1 |
Dioxygen increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
22629407
Choline affects USP45
1 |
Choline decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
20938992
Cadmium dichloride demethylates USP45. 1 / 1
1 |
ctd
No evidence text available
22457795
Bortezomib affects USP45
1 |
Bortezomib increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
20977926
Benzo[e]pyrene affects USP45
1 |
Benzo[e]pyrene methylates USP45. 1 / 1
1 |
ctd
No evidence text available
30157460
Alpha-D-galactose affects USP45
| 1
Alpha-D-galactose activates USP45. 1 / 1
| 1
reach
"We also show that the usp45 promoter is highly activated by galactose."
32532874
Aflatoxin B2 affects USP45
1 |
Aflatoxin B2 methylates USP45. 1 / 1
1 |
ctd
No evidence text available
30157460
YLPM1 affects USP45
1 |
YLPM1 binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
XPF-ERCC1 affects USP45
| 1
XPF-ERCC1 activates USP45. 1 / 1
| 1
reach
"On this basis, we speculate that is likely that XPF-ERCC1 is the major target of USP45 in controlling DNA repair."
25538220
WIZ affects USP45
1 |
USP45 binds WIZ. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP45 affects secretion heterologous protein L. lactis
| 1
USP45 activates secretion heterologous protein L. lactis. 1 / 1
| 1
eidos
"One report concluded that usp45 could enhance secretion to increase heterologous protein production in L. lactis [ 21 ] ."
31015862
USP45 affects sacA
| 1
USP45 activates sacA. 1 / 1
| 1
reach
"Removal of the USP45 secretion peptide allowed a soluble and functional invertase to be expressed intracellularly in L. lactis."
28155177
USP45 affects plasmin
| 1
USP45 increases the amount of plasmin. 1 / 1
| 1
reach
"Expression of the plasmin gene driven by the promoter and complete signal sequence of the lactococcal usp45 gene resulted in efficient plasmin secretion in strain BPL420."
9352676
USP45 affects peptide
| 1
USP45 activates peptide. 1 / 1
| 1
reach
"Analysis of the amino acid sequences performed on the two hsTRAIL protein bands showed that the upper (larger) band represents a slightly truncated form of hsTRAIL containing 160 amino acid (aa) residues, while the lower (smaller) band represents a more truncated form of hsTRAIL deprived of 37 aa residues from the N-terminus of the protein, both having the bacterial usp45 leading peptide cut off."
30446013
USP45 affects natural small molecule
| 1
USP45 binds natural small molecule. 1 / 1
| 1
reach
"Moreover, we have identified that USP45 can be specifically bound and inhibited by a natural small molecule (α-mangostin), in turn significantly suppressing USP45-induced stemness and drug resistance."
36765885
USP45 affects migration velocity
| 1
USP45 activates migration velocity. 1 / 1
| 1
eidos
"Our data indicate that the lack of USP45 reduces migration velocity compared to wild-type cells ."
30258100
USP45 affects miR-30e-5p
| 1
USP45 activates miR-30e-5p. 1 / 1
| 1
reach
"Furthermore, Usp45 is also potential target of miR-30e-5p which is a regulator of XPF-ERCC1 crucial for efficient DNA repair [XREF_BIBR]."
26439850
USP45 affects localization
| 1
USP45 activates localization. 1 / 1
| 1
reach
"The Usp45 secretion and spaX (S. aureus protein A) anchor signals efficiently promote the localization of FNIII 7-10 in the bacterial membrane."
25068919
USP45 affects dimer
| 1
USP45 activates dimer. 1 / 1
| 1
reach
"Fig. 2D indicate that recombinant USP45 WT is able to mediate the cleavage of 100% of the K6, K48 and K63 dimer in 60 min."
30258100
USP45 affects cell migration
| 1
reach
"USP45 depleted cells were defective in cell migration and the defects observed were not produced by off-target effects: phenotypic rescue could be achieved only by re-expressing the catalytically active USP45 and not with the inactive mutant C199A, suggesting a potential interplay of Spindly and USP45 in cell migration (Fig. 5C)."
30258100
USP45 affects alpha-amylase
| 1
USP45 activates alpha-amylase. 1 / 1
| 1
reach
"Fusion of the usp45 promoter region and various parts of the leader sequence to an amyS gene devoid of its signal sequence, showed that in Escherichia coli the first 19, 20, and 27 residues of the Usp45 leader are able to direct alpha-amylase secretion."
8413193
USP45 affects acmA
| 1
USP45 activates acmA. 1 / 1
| 1
reach
"To verify whether IL-23-specific ILP protein binders can be produced in L. lactis host cells, DNA sequences coding for ILP proteins (ILP030, ILP317 and ILP323 variants) were genetically fused to Usp45 secretion signal and C-terminal domain of AcmA protein (cA) containing LysM repeats (LysM) for peptidoglycan anchoring."
29966384
USP45 affects YLPM1
1 |
YLPM1 binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects WIZ
1 |
USP45 binds WIZ. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP45 affects USP1
| 1
USP1 binds FBXL7 and USP45. 1 / 1
| 1
sparser
"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12. xref These deubiquitylation enzymes could counteract SCF Fbxl18 to remove ubiquitin from Fbxl7 to prevent its degradation."
25654763
USP45 affects TMOD3
1 |
TMOD3 binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects TGFBR1
1 |
TGFBR1 binds USP45. 1 / 1
1 |
hprd
No evidence text available
15761153
USP45 affects SRBD1
1 |
USP45 binds SRBD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects SMURF1
1 |
SMURF1 binds USP45. 1 / 1
1 |
hprd
No evidence text available
15761153
USP45 affects SMAD1
1 |
USP45 binds SMAD1. 1 / 1
1 |
hprd
No evidence text available
15761153
USP45 affects SF3A2
1 |
SF3A2 binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects SAFB
1 |
SAFB binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects RTCA
1 |
RTCA binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects RBM7
1 |
USP45 binds RBM7. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP45 affects RALY
1 |
RALY binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects PPP5C
1 |
USP45 binds PPP5C. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP45 affects POLR2G
1 |
USP45 binds POLR2G. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects PIK3CG
1 |
USP45 binds PIK3CG. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects NOP53
1 |
USP45 binds NOP53. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects MYL6
1 |
USP45 binds MYL6. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects LiaRS
| 1
USP45 activates LiaRS. 1 / 1
| 1
reach
"Usp45 and TEM-1 IA (2)-lactamase specifically induce the LiaRS dependent response."
22624725
USP45 affects LCN2
| 1
USP45 activates LCN2. 1 / 1
| 1
reach
"Construction of Lcn2 under the P1 promoter allows for constitutive expression, whereas USP45 encodes for the sequence signal to drive the secretion of Lcn2 from L. lactis."
28445245
USP45 affects IGKV4-1
1 |
USP45 binds IGKV4-1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects GUCY2D
| 1
USP45 binds GUCY2D. 1 / 1
| 1
sparser
"Our study implicates that biallelic mutations in USP45 are associated with the occurrence of LCA."
30573563
USP45 affects FlaG
| 1
USP45 binds SPDL1 and FlaG. 1 / 1
| 1
sparser
"This suggests that Spindly could be potentially be mono-ubiquitylated instead of poly-ubiquitylated: Treatment of the IP of Spindly-FLAG with recombinant USP45 WT showed a removal of the potential Spindly mono-ubiquitylation band (Fig.  xref , right panel)."
30258100
USP45 affects FLNA
1 |
USP45 binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects FARS2
1 |
USP45 binds FARS2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects DNA Damage
| 1
USP45 activates DNA Damage. 1 / 1
| 1
reach
"Taken together, these data indicate that USP45 localises at sites of UV induced DNA damage, and at intra- and interstrand cross-links, and that USP45 is required, like ERCC1 for efficient NER."
25538220
USP45 affects Carcinogenesis
| 1
USP45 activates Carcinogenesis. 1 / 1
| 1
reach
"Since USP45 is significantly expressed in cervical tumors, we have discovered that the combination of α-mangostin and doxorubicin can significantly inhibit USP45-induced cervical tumorigenesis in an animal model."
36765885
USP45 affects CORO1C
1 |
USP45 binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects CDK1
1 |
CDK1 binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 affects BMPR1B
1 |
BMPR1B binds USP45. 1 / 1
1 |
hprd
No evidence text available
15761153
USP45 affects ARID1A
| 1
ARID1A binds USP45. 1 / 1
| 1
reach
"We further investigated shared segments and WES for evidence supporting the complexes USP45 and ARID1A are involved in."
29389935
USP1 affects USP45
| 1
USP1 binds FBXL7 and USP45. 1 / 1
| 1
sparser
"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12. xref These deubiquitylation enzymes could counteract SCF Fbxl18 to remove ubiquitin from Fbxl7 to prevent its degradation."
25654763
TMOD3 affects USP45
1 |
TMOD3 binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
TGFBR1 affects USP45
1 |
TGFBR1 binds USP45. 1 / 1
1 |
hprd
No evidence text available
15761153
SRBD1 affects USP45
1 |
USP45 binds SRBD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
SPINK1 affects USP45
| 1
SPINK1 activates USP45. 1 / 1
| 1
reach
"The psaA gene was cloned into the pT1NX vector PstI site, which produced a fusion of a truncated usp45 signal peptide carried by the vector to the PsaA sequence (Fig. 1), under the control of a constitutive promoter."
16549380
SPDL1 affects FlaG
| 1
USP45 binds SPDL1 and FlaG. 1 / 1
| 1
sparser
"This suggests that Spindly could be potentially be mono-ubiquitylated instead of poly-ubiquitylated: Treatment of the IP of Spindly-FLAG with recombinant USP45 WT showed a removal of the potential Spindly mono-ubiquitylation band (Fig.  xref , right panel)."
30258100
SMURF1 affects USP45
1 |
SMURF1 binds USP45. 1 / 1
1 |
hprd
No evidence text available
15761153
SMAD1 affects USP45
1 |
USP45 binds SMAD1. 1 / 1
1 |
hprd
No evidence text available
15761153
SF3A2 affects USP45
1 |
SF3A2 binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
SAFB affects USP45
1 |
SAFB binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
RTCA affects USP45
1 |
RTCA binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
RBM7 affects USP45
1 |
USP45 binds RBM7. 1 / 1
1 |
biogrid
No evidence text available
26496610
RALY affects USP45
1 |
RALY binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
PPP5C affects USP45
1 |
USP45 binds PPP5C. 1 / 1
1 |
biogrid
No evidence text available
26496610
POLR2G affects USP45
1 |
USP45 binds POLR2G. 1 / 1
1 |
biogrid
No evidence text available
19615732
PIK3CG affects USP45
1 |
USP45 binds PIK3CG. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP45 is modified
| 1
USP45 is ubiquitinated. 1 / 1
| 1
sparser
"Given that USP45 is a DUB, we decided to explore the ubiquitylation in the Spindly-USP45 complex."
30258100
NOP53 affects USP45
1 |
USP45 binds NOP53. 1 / 1
1 |
biogrid
No evidence text available
19615732
MYL6 affects USP45
1 |
USP45 binds MYL6. 1 / 1
1 |
biogrid
No evidence text available
19615732
Leber Congenital Amaurosis activates USP45. 1 / 1
| 1
reach
"Biallelic LoF mutations in USP45 cause Leber congenital amaurosis, a severe form of inherited retinal dystrophies that results in irreversible childhood blindness (45)."
35662507
L-methionine affects USP45
1 |
L-methionine decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
20938992
IGKV4-1 affects USP45
1 |
USP45 binds IGKV4-1. 1 / 1
1 |
biogrid
No evidence text available
19615732
GUCY2D affects USP45
| 1
USP45 binds GUCY2D. 1 / 1
| 1
sparser
"Our study implicates that biallelic mutations in USP45 are associated with the occurrence of LCA."
30573563
FlaG affects USP45
| 1
USP45 binds SPDL1 and FlaG. 1 / 1
| 1
sparser
"This suggests that Spindly could be potentially be mono-ubiquitylated instead of poly-ubiquitylated: Treatment of the IP of Spindly-FLAG with recombinant USP45 WT showed a removal of the potential Spindly mono-ubiquitylation band (Fig.  xref , right panel)."
30258100
FLNA affects USP45
1 |
USP45 binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
19615732
FBXL7 affects USP1, and USP45
| 1
USP1 binds FBXL7 and USP45. 1 / 1
| 1
sparser
"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12. xref These deubiquitylation enzymes could counteract SCF Fbxl18 to remove ubiquitin from Fbxl7 to prevent its degradation."
25654763
FARS2 affects USP45
1 |
USP45 binds FARS2. 1 / 1
1 |
biogrid
No evidence text available
19615732
Cuprizone affects USP45
1 |
Cuprizone decreases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
26577399
Casp14 affects USP45
| 1
Casp14 activates USP45. 1 / 1
| 1
reach
"In agreement with these clinical findings, the LL-IL35-treated mice had markedly reduced Ly-6G + CD11b + cells (neutrophils) infiltrating the joints (Figure 2A ) representing a 7-and 5-fold reduction compared to The synthetic insert encodes in order: the usp45 secretion peptide genetically fused in-frame to the p35 subunit, a short flexible linker, fused to the EBI3."
30515168
CORO1C affects USP45
1 |
USP45 binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
19615732
CDK1 affects USP45
1 |
CDK1 binds USP45. 1 / 1
1 |
biogrid
No evidence text available
19615732
BMPR1B affects USP45
1 |
BMPR1B binds USP45. 1 / 1
1 |
hprd
No evidence text available
15761153
ARID1A affects USP45
| 1
ARID1A binds USP45. 1 / 1
| 1
reach
"We further investigated shared segments and WES for evidence supporting the complexes USP45 and ARID1A are involved in."
29389935
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP45. 1 / 1
1 |
ctd
No evidence text available
32109520