IndraLab

Statements


USP31 affects NFkappaB
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USP31 inhibits NFkappaB.
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"USP31 and USP7 also inhibit NF-kappaB signaling by deubiquitinating K63 linked polyubiquitin chains [XREF_BIBR, XREF_BIBR]."

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"USP31 overexpression inhibited NF-kappaB activation mediated by TNFalpha and two members of the TNFR family, CD40 and LMP1, whereas it had no effect on the basal NF-kappaB activity."

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"USP31 also inhibited NF-kappaB activation mediated by two TRAF proteins (TRAF2 and TRAF6), as well as by the IKKbeta kinase."

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"YAP1 Mediated Suppression of USP31 Enhances NFkappaB Activity to Promote Sarcomagenesis."

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"USP31 and USP7 also inhibit NF-kappaB signaling by deubiquitinating K63-linked polyubiquitin chains [ 38,39 ] ."
USP31 activates NFkappaB.
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"The inhibition of NF-kappaB activation by USP31 was not due to a reduction of effector protein expression, since Western blot analysis revealed that the levels of all effector proteins were unaffected[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"These results reinforce the notion that USP31 has a specific role in NF-kappaB activation induced by TRAFs and members of the TNFR family.The nuclear localization of USP31 and its implication in NF-ka[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
USP31 is modified
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USP31 is phosphorylated.
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USP31 is phosphorylated on T1056. 1 / 1
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No evidence text available
USP31 is phosphorylated on S1241. 1 / 1
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No evidence text available
USP31 is phosphorylated on S1052. 1 / 1
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No evidence text available
USP31 is phosphorylated on T5. 1 / 1
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No evidence text available
USP31 is acetylated.
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USP31 is acetylated on K1264. 1 / 1
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"USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth."
USP31 is acetylated on K1236. 1 / 1
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No evidence text available
RELA affects USP31
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RELA binds USP31.
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"A candidate target of USP31 could be p65 and RelA, since there is a physical interaction between USP31 and p65 as indicated by the immunoprecipitation experiments."

No evidence text available
RELA activates USP31.
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RELA activates USP31. 2 / 2
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"p65 and RelA is a possible target of USP31, since it is a major component of NF-kappaB and it is ubiquitinated and degraded by the proteasome in the nucleus [12]."

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"P65 and RelA is a possible target of USP31, since it is a major component of NF-kappaB and it is ubiquitinated and degraded by the proteasome in the nucleus [12]."
USP31 affects TRAF2
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USP31 inhibits TRAF2.
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USP31 inhibits TRAF2. 1 / 2
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"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
USP31 binds TRAF2.
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"To confirm that the interaction between TRAF2 and USP31 in mammalian cells occurs via the RING finger domain of TRAF2, as indicated by our two-hybrid results, a mutated form of TRAF2 with a RING finge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
USP31 affects RELA
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"A candidate target of USP31 could be p65 and RelA, since there is a physical interaction between USP31 and p65 as indicated by the immunoprecipitation experiments."

No evidence text available
Silver(0) affects USP31
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Silver(0) decreases the amount of USP31. 2 / 2
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No evidence text available

No evidence text available
Paracetamol affects USP31
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Paracetamol increases the amount of USP31. 2 / 2
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No evidence text available

No evidence text available
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Aflatoxin B1 increases the amount of USP31. 2 / 2
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No evidence text available

No evidence text available
YAP1 affects USP31
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YAP1 inhibits USP31. 2 / 2
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"YAP1 promoted sarcomagenesis by inhibiting expression of ubiquitin specific peptidase 31 (USP31), a newly identified upstream negative regulator of NFkappaB signaling."

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"It is worth noting that YAP1 was shown to inhibit the negative regulatory factor of NF-κB USP31 and induce excessive tumor cell proliferation."
USP31 affects TRAF6
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USP31 inhibits TRAF6. 1 / 2
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"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
USP31 affects CD40
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USP31 inhibits CD40. 1 / 2
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"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
TRAF2 affects USP31
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No evidence text available

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"To confirm that the interaction between TRAF2 and USP31 in mammalian cells occurs via the RING finger domain of TRAF2, as indicated by our two-hybrid results, a mutated form of TRAF2 with a RING finge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
SREBF1 affects USP31
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SREBF1 decreases the amount of USP31. 2 / 2
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No evidence text available

No evidence text available
Vinclozolin affects USP31
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Vinclozolin decreases the amount of USP31. 1 / 1
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No evidence text available
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Valproic acid increases the amount of USP31. 1 / 1
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No evidence text available

No evidence text available
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Thioacetamide increases the amount of USP31. 1 / 1
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No evidence text available
Tetrachloromethane increases the amount of USP31. 1 / 1
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No evidence text available
Sunitinib affects USP31
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Sunitinib increases the amount of USP31. 1 / 1
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No evidence text available
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Sodium arsenite increases the amount of USP31. 1 / 1
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No evidence text available
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Schizandrin B increases the amount of USP31. 1 / 1
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No evidence text available
Leflunomide affects USP31
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Leflunomide increases the amount of USP31. 1 / 1
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No evidence text available
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No evidence text available
Lead atom affects USP31
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Lead atom decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-92a-3p decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-7-5p decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-574-3p decreases the amount of USP31. 1 / 1
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No evidence text available
Hsa-miR-375 affects USP31
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Hsa-miR-375 decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-374a-5p decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-23b-3p decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-195-5p decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-16-5p decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-15b-5p decreases the amount of USP31. 1 / 1
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No evidence text available
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Hsa-miR-15a-5p decreases the amount of USP31. 1 / 1
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No evidence text available
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Formaldehyde increases the amount of USP31. 1 / 1
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No evidence text available
Ethyl methanesulfonate increases the amount of USP31. 1 / 1
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No evidence text available
Endosulfan affects USP31
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Endosulfan increases the amount of USP31. 1 / 1
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No evidence text available
Doxorubicin affects USP31
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Doxorubicin decreases the amount of USP31. 1 / 1
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No evidence text available
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Cyclosporin A increases the amount of USP31. 1 / 1
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No evidence text available
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Crotonaldehyde decreases the amount of USP31. 1 / 1
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No evidence text available
Copper(II) sulfate increases the amount of USP31. 1 / 1
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No evidence text available
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Cobalt dichloride decreases the amount of USP31. 1 / 1
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No evidence text available
Butanal affects USP31
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Butanal decreases the amount of USP31. 1 / 1
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No evidence text available
Bisphenol A affects USP31
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Bisphenol A decreases the amount of USP31. 1 / 1
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No evidence text available
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Benzo[a]pyrene decreases the amount of USP31. 1 / 1
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No evidence text available
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No evidence text available
Acetamide affects USP31
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Acetamide decreases the amount of USP31. 1 / 1
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No evidence text available
Abrine affects USP31
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Abrine increases the amount of USP31. 1 / 1
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No evidence text available
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Zoledronic Acid increases the amount of USP31. 1 / 1
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No evidence text available

eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
USP31 affects cell cycle
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"We also observed that mutated USP31 could promote apoptosis but not cell cycle by flow cytometer analysis."
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"We also observed that mutated USP31 could promote apoptosis but not cell cycle by flow cytometer analysis."
USP31 affects USP31
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USP31 inhibits USP31. 1 / 1
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"Overexpression of mutated USP31 could reverse the effect in USP31 knockdown cell line."
USP31 affects TNF
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USP31 inhibits TNF. 1 / 1
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"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
USP31 affects GPX4
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"Furthermore, GPX4 protein specifically binds the deubiquitinase USP31, but not other deubiquitinases such as CYLD, USP1, USP14, USP20, USP30, USP38, UCHL1, UCHL3, and UCHL5."
USP31 affects EGFR
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No evidence text available
USP31 affects CTDSPL
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No evidence text available
Tobacco Smoke Pollution increases the amount of USP31. 1 / 1
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No evidence text available
T-2 Toxin affects USP31
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T-2 Toxin decreases the amount of USP31. 1 / 1
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No evidence text available
Smoke affects USP31
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Smoke decreases the amount of USP31. 1 / 1
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No evidence text available
PCB 180 affects USP31
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PCB 180 decreases the amount of USP31. 1 / 1
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No evidence text available
PAX4 affects USP31
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PAX4 decreases the amount of USP31. 1 / 1
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No evidence text available
MYC affects USP31
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MYC decreases the amount of USP31. 1 / 1
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No evidence text available
LEF1 affects USP31
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LEF1 decreases the amount of USP31. 1 / 1
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No evidence text available
K 7174 affects USP31
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K 7174 increases the amount of USP31. 1 / 1
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No evidence text available
HDAC_III affects USP31
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HDAC_III leads to the acetylation of USP31. 1 / 1
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"To further investigate its activity in tumorigenesis, deacetylase sirtuin 1 (Sirt1) was shown to interact with USP31 by co-immunoprecipitation and blocking the function of Sirt1 by knockdown or the inhibitor nicotinamide could increase the acetylation of USP31."
GPX4 affects USP31
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"Furthermore, GPX4 protein specifically binds the deubiquitinase USP31, but not other deubiquitinases such as CYLD, USP1, USP14, USP20, USP30, USP38, UCHL1, UCHL3, and UCHL5."
ESRRA affects USP31
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ESRRA decreases the amount of USP31. 1 / 1
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No evidence text available
EGFR affects USP31
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No evidence text available
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Dietary Sucrose increases the amount of USP31. 1 / 1
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No evidence text available
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Dietary Fats decreases the amount of USP31. 1 / 1
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No evidence text available
Cuprizone affects USP31
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Cuprizone decreases the amount of USP31. 1 / 1
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No evidence text available
CTDSPL affects USP31
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No evidence text available
Antirheumatic Agents increases the amount of USP31. 1 / 1
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No evidence text available
Acetylation affects USP31
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"Therefore , acetylation at Lys1264 suppresses USP31 activity and plays a protective role in cancer cell growth ."
ARNT affects USP31
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ARNT decreases the amount of USP31. 1 / 1
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No evidence text available
6-propyl-2-thiouracil decreases the amount of USP31. 1 / 1
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No evidence text available
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No evidence text available
17alpha-ethynylestradiol increases the amount of USP31. 1 / 1
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No evidence text available
1-phenylpropan-2-amine decreases the amount of USP31. 1 / 1
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No evidence text available
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No evidence text available
2,4,4'-trichlorobiphenyl decreases the amount of USP31. 1 / 1
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No evidence text available
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No evidence text available
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No evidence text available
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No evidence text available