IndraLab

Statements

CGAS affects USP29
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USP29 binds cGAS. 10 / 23
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sparser
"Because USP29 interacted with cGAS and was upregulated by HSV-1 infection, we investigated its role in regulating HSV-1- or cytoplasmic DNA-triggered innate immune signaling."
32457395
sparser
"39,42 Because USP29 interacted with cGAS and was upregulated by HSV-1 infection, we investigated its role in regulating HSV-1- or cytoplasmic DNA-triggered innate immune signaling."
32457395
sparser
"Interestingly, we found that TRIM38 constitutively interacts with cGAS but not with USP29, whereas USP29 constitutively interacts with cGAS but not with TRIM38 (Supplementary information, Fig.  xref ), indicating that TRIM38 and USP29 independently interacts with and regulates cGAS."
32457395
sparser
"Together, these data suggest that USP29 interacts with cGAS directly and constitutively in resting cells and after HSV-1 infection."
32457395
sparser
"Domain mapping analysis showed that the ubiquitin carboxyl-terminal hydrolase (UCH) domain of USP29 and the C-terminal domain containing the nucleotidyltransferase (NTase) domain of cGAS were responsible for USP29-cGAS association (Fig.  xref )."
32457395
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"c Proximity ligation assay (PLA) and confocal microscopy imaging of cGAS and USP29 interaction in MEFs that were left uninfected (Mock) or infected with HSV-1 for 4 h (left images)."
32457395
sparser
"It has been proposed that three pools of cGAS exist in uninfected cells: unmodified, Lys217-sumoylated and constitutively Lys271-ubiquitinated cGAS. xref Sumoylation at Lys217 antagonizes K48-linked ubiquitination of Lys271 of cGAS, thereby inhibiting its proteasomal degradation. xref In our study, we found that USP29 constitutively interacted with cGAS and USP29 deficiency substantially potentiated basal K48-linked ubiquitination of cGAS and downregulated cGAS protein level without affecting its mRNA expression in uninfected cells, indicating that USP29 constitutively removes K48-linked ubiquitination of cGAS to maintain a relatively high level of cGAS under steady conditions."
32457395
sparser
"In addition, USP29 selectively interacted with cGAS but not with other molecules including MITA, RIG-I, MAVS, TBK1 or IRF3 (Supplementary information, Fig.  xref )."
32457395
sparser
"USP29 deubiquitinates cGAS in the presence or absence of HSV-1 infection Because USP29 interacts with cGAS and its enzyme activity is required for regulating antiviral signaling, we investigated b ELISA analysis of IFN-β, IFN-α, TNF, and CCL5 in the supernatants of Usp29 +/+ and Usp29 m/m BMDMs infected with HSV-1 for 0-24 h, or mock transfected (Mock) or transfected with DNA90, HSV60 or HSV120 for 12 h."
32457395
sparser
"Previous studies have demonstrated that accumulation of dsDNA in the cytoplasm induces micronuclei-localization of cGAS. xref , xref , xref In our study, we found that a portion of USP29-cGAS associating spots were localized at perinuclear compartments after HSV-1 infection."
32457395
USP25 binds USP29 and cGAS. 3 / 3
| 3
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established, xref – xref and found that USP25 and USP29 interacted with cGAS in such a system (Fig.  xref )."
32457395
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established, [35] [36] [37] and found that USP25 and USP29 interacted with cGAS in such a system (Fig. 1a) ."
32457395
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established,35–37 and found that USP25 and USP29 interacted with cGAS in such a system (Fig. 1a)."
32457395
TRIM38 binds USP29 and cGAS. 1 / 1
| 1
sparser
"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38-mediated sumoylation and USP29-mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
USP29 binds cGAS. 1 / 1
| 1
isi
"Mechanistically, USP29 constitutively interacts with cGAS, deconjugates K48-linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection."
32457395
USP29 affects CGAS
| 20
USP29 binds CGAS.
| 11
USP29 binds CGAS. 8 / 8
| 8
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"In addition, USP29 selectively interacted with cGAS but not with other molecules including MITA, RIG-I, MAVS, TBK1 or IRF3 (Supplementary information, Fig.S2d)."
32457395
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"Interestingly, we found that TRIM38 constitutively interacts with cGAS but not with USP29, whereas USP29 constitutively interacts with cGAS but not with TRIM38 (Supplementary information, Fig.S2h), indicating that TRIM38 and USP29 independently interacts with and regulates cGAS."
32457395
reach
"Because USP29 interacts with cGAS and its enzyme activity is required for regulating antiviral signaling, we investigated whether USP29 eliminated polyubiquitin chains from cGAS."
32457395
reach
"Together, these data suggest that USP29 interacts with cGAS directly and constitutively in resting cells and after HSV-1 infection."
32457395
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"To test this hypothesis, we conducted an unbiased screening of cGAS interacting DUBs by cotransfection and immunoprecipitation assays as previous established, XREF_BIBR - XREF_BIBR and found that USP25 and USP29 interacted with cGAS in such a system."
32457395
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"Results from endogenous immunoprecipitation assays suggested that USP29 constitutively interacted with cGAS in bone marrow derived macrophages (BMDMs), bone marrow derived dendritic cells (BMDCs), mouse embryonic fibroblasts (MEFs), mouse lung fibroblasts (MLFs) or human monocytic THP-1 cells and their association was potentiated after HSV-1 infection."
32457395
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"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38 mediated sumoylation and USP29 mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
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"Because USP29 interacted with cGAS and was upregulated by HSV-1 infection, we investigated its role in regulating HSV-1- or cytoplasmic DNA triggered innate immune signaling."
32457395
USP29 binds CGAS and K48. 3 / 3
| 3
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"Mechanistically, USP29 constitutively interacts with cGAS, deconjugates K48 linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection."
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"[208] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48 linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV-1 stimulation."
33511009
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"USP29 constitutively interacts with cGAS and deconjugates K48 linked polyubiquitin chains from cGAS in the absence or presence of HSV-1 infection, which stabilizes cGAS and promotes cGAS mediated cellular antiviral responses."
32457395
USP29 deubiquitinates CGAS.
| 3
USP29 deubiquitinates CGAS-K464R. 2 / 2
| 2
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"In support of this notion, we found that USP29 deubiquitinated cGAS (K464R) but did not affect the ubiquitination of cGAS (K271R)."
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"In this context, we noted that USP29 inhibited ubiquitination of cGAS (K464R) but not cGAS (K271R) after HSV-1 infection, and that knockout of USP29 potentiated ubiquitination of cGAS (K464R) but not cGAS (K271R) before or after HSV-1 infection."
32457395
USP29 deubiquitinates CGAS. 1 / 1
| 1
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"USP29 deubiquitinates cGAS in the presence or absence of HSV-1 infection."
32457395
USP29 activates CGAS.
| 3
USP29 activates CGAS. 3 / 3
| 3
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"These data together suggest that USP29 deconjugates K48 linked polyubiquitin chains from cGAS and thereby inhibits the proteasomal degradation of cGAS."
32457395
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"In contrast, cGAS was still degraded in Usp29 m/m MLFs (half-life ~ 8h) after HSV-1 infection, which was due to inefficient induction of cGas transcription and accelerated degradation of basal and newly synthesized cGAS caused by the absence of USP29."
32457395
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"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38 mediated sumoylation and USP29 mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
USP29 increases the amount of CGAS.
| 2
USP29-C298A increases the amount of CGAS. 1 / 1
| 1
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"In addition, reconstitution of USP29 but not USP29 (C298A) into Usp29 m/m MEFs restored the protein levels of cGAS with or without HSV-1 infection and cGAMP production after cytoplasmic DNA challenge."
32457395
USP29 increases the amount of CGAS. 1 / 1
| 1
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"In addition, reconstitution of USP29 but not USP29 (C298A) into Usp29 m/m MEFs restored the protein levels of cGAS with or without HSV-1 infection and cGAMP production after cytoplasmic DNA challenge."
32457395
USP29 ubiquitinates CGAS.
| 1
USP29 ubiquitinates CGAS. 1 / 1
| 1
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"XREF_BIBR - XREF_BIBR Because USP29 dubiquitinates and stabilizes cGAS, it is worthy to investigate whether USP29 regulates the cGAS related autophagy or senescence."
32457395
CGAS affects USP29
| 12
CGAS binds USP29.
| 11
USP29 binds CGAS. 8 / 8
| 8
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"In addition, USP29 selectively interacted with cGAS but not with other molecules including MITA, RIG-I, MAVS, TBK1 or IRF3 (Supplementary information, Fig.S2d)."
32457395
reach
"Interestingly, we found that TRIM38 constitutively interacts with cGAS but not with USP29, whereas USP29 constitutively interacts with cGAS but not with TRIM38 (Supplementary information, Fig.S2h), indicating that TRIM38 and USP29 independently interacts with and regulates cGAS."
32457395
reach
"Because USP29 interacts with cGAS and its enzyme activity is required for regulating antiviral signaling, we investigated whether USP29 eliminated polyubiquitin chains from cGAS."
32457395
reach
"Together, these data suggest that USP29 interacts with cGAS directly and constitutively in resting cells and after HSV-1 infection."
32457395
reach
"To test this hypothesis, we conducted an unbiased screening of cGAS interacting DUBs by cotransfection and immunoprecipitation assays as previous established, XREF_BIBR - XREF_BIBR and found that USP25 and USP29 interacted with cGAS in such a system."
32457395
reach
"Results from endogenous immunoprecipitation assays suggested that USP29 constitutively interacted with cGAS in bone marrow derived macrophages (BMDMs), bone marrow derived dendritic cells (BMDCs), mouse embryonic fibroblasts (MEFs), mouse lung fibroblasts (MLFs) or human monocytic THP-1 cells and their association was potentiated after HSV-1 infection."
32457395
reach
"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38 mediated sumoylation and USP29 mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
reach
"Because USP29 interacted with cGAS and was upregulated by HSV-1 infection, we investigated its role in regulating HSV-1- or cytoplasmic DNA triggered innate immune signaling."
32457395
USP29 binds CGAS and K48. 3 / 3
| 3
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"Mechanistically, USP29 constitutively interacts with cGAS, deconjugates K48 linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection."
32457395
reach
"[208] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48 linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV-1 stimulation."
33511009
reach
"USP29 constitutively interacts with cGAS and deconjugates K48 linked polyubiquitin chains from cGAS in the absence or presence of HSV-1 infection, which stabilizes cGAS and promotes cGAS mediated cellular antiviral responses."
32457395
CGAS inhibits USP29.
| 1
CGAS inhibits USP29. 1 / 1
| 1
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"Interestingly, the levels of cGAS and the expression of Tnf, Il6, Il12p40 and Ifit3 were significantly decreased in Trex1 -/- Usp29 m/m BMDCs compared to Trex1 -/- BMDCs (Supplementary information, Fig.S7d)."
32457395
USP29 affects apoptotic process
| 1 10
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"We also demonstrated that USP29 depletion hampers the colony formation and increases apoptosis of HCT116 cells."
34072621
eidos
"Recently , a study reported that USP29 depletion decreased apoptosis by regulating the Snail protein [ 13 ] ."
34072621
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"Collectively, these findings imply that USP29 potentiates I/R-induced oxidative damage and neuronal apoptosis in vitro."
34824671
reach
"Neuron-specific USP29 knockout significantly diminishes, whereas USP29 overexpression aggravates cerebral I/R-induced oxidative stress, apoptosis, and neurological dysfunction in vivo and in vitro."
34824671
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"During stress, USP29 removes the polyubiquitin chain from p53 thus stabilizing it and induces p53 dependent apoptosis."
29479529
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"Our findings for the first time identify that USP29 upregulation during cerebral I/R may contribute to oxidative stress, neuronal apoptosis, and the progression of cerebral I/R injury and that inhibition of USP29 may help to develop novel therapeutic strategies to treat cerebral I/R injury."
34824671
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"In addition, OGD/R-induced oxidative stress and neuronal apoptosis were also attenuated by USP29 silence but exacerbated by USP29 overexpression in vitro."
34824671
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"Liu et al. reported that USP29 expression was elevated upon oxidative stress and then promoted cell apoptosis via directly deubiquitinating p53 [25]."
34824671
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"Generally, our findings for the first time identify that USP29 upregulation during cerebral I/R may contribute to oxidative stress, neuronal apoptosis, and the progression of cerebral I/R injury and that inhibition of USP29 may help to develop novel therapeutic strategies to treat cerebral I/R injury.Multiple mechanisms are implicated in the pathogenesis of cerebral I/R injury, including oxidative stress and apoptosis."
34824671
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"Based on the above results, we conclude that USP29 upregulation during cerebral I/R injury potentiates oxidative stress, apoptosis, and neurological dysfunction in mice."
34824671
USP29 affects SNAI1
| 6 5
USP29 binds SNAI1.
| 2 5
SNAI1 binds USP29. 7 / 7
| 2 5
sparser
"Considering the pivotal roles that Snail1 plays during the development of resistance to chemotherapies, we posited that the USP29-Snail1 axis might be exploited by cancer cells in their acquisition of chemoresistance."
32968046
sparser
"USP29 interacts with Snail1 and requires catalytic activity to stabilize Snail1."
32968046
reach
"These observations imply the necessity of USP29 DUB activity in the regulation of Snail1, but the exact roles of USP29 mutations detected in cancer samples require further clarification.To evaluate the interaction between Snail1 and USP29, we carried out a series of co-immunoprecipitation experiments."
32968046
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"We then moved to investigate the potential interaction between USP29 and Snail1."
32968046
sparser
"Cancer cells hijack the USP29-Snail1 axis to facilitate chemoresistance."
32968046
sparser
"To evaluate the interaction between Snail1 and USP29, we carried out a series of co-immunoprecipitation experiments."
32968046
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"We then moved to investigate the potential interaction between USP29 and Snail1."
32968046
USP29 activates SNAI1.
| 2
USP29 activates SNAI1. 2 / 2
| 2
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"Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein."
32973332
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"USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress."
32968046
USP29 ubiquitinates SNAI1.
| 1
USP29 leads to the ubiquitination of SNAI1. 1 / 1
| 1
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"Subsequent sub-screening identified 23 DUBs that interact with SNAI1, out of which USP29, USP36, and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein."
| PMC
USP29 decreases the amount of SNAI1.
| 1
USP29-C294A decreases the amount of SNAI1. 1 / 1
| 1
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"In addition, the dose-escalating expression of the C294A USP29 mutant effectively suppressed Snail1 expression levels, suggesting a dominant-negative role of the catalytic inactive version that overwhelms the endogenous wild-type USP29 (Fig. 3d)."
32968046
USP29 affects CLSPN
2 1 | 1 4
USP29 binds CLSPN.
2 | 1 1
USP29 binds CLSPN. 4 / 5
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"USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro."
24632611
biogrid
No evidence text available
24632611
trips
"USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro."
24632611
biogrid
No evidence text available
24632611
USP29 activates CLSPN.
| 2
USP29 activates CLSPN. 2 / 3
| 2
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"The deubiquitinases USP9X and USP29 promote Claspin stabilization during the S phase, and thus, adequate replication fork progression, by opposing its proteasomal degradation [23,24]."
28942358
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"A recent report indicates that USP29 promotes CLASPIN (not CHK1) stability, ensuring CHK1 activation in response to UV irradiation."
25326330
USP29 increases the amount of CLSPN.
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USP29 increases the amount of CLSPN. 1 / 1
| 1
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"In contrast, knockdown of endogenous USP29 (TOV21G cells transfected with sh-USP29) did not reduce the Claspin protein expression (data not shown)."
29707125
USP29 deubiquitinates CLSPN.
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USP29 deubiquitinates CLSPN. 1 / 1
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ubibrowser
"USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination"
24632611
USP29 affects SIRT1
| 4 5
USP29 inhibits SIRT1.
| 2 1
USP29 inhibits SIRT1. 3 / 3
| 2 1
eidos
"USP29 Inhibits SIRT1 Expression via p53 / miR-34a Axis Finally , we explored the possible mechanism through which USP29 modulated SIRT1 expression ."
34824671
reach
"Accordingly, USP29 overexpression-induced SIRT1 inhibition was prevented in mice treated with either PFT-α or miR-34a antagomir (Figure 6(k))."
34824671
eidos
"Based on these results , we demonstrate that USP29 inhibits SIRT1 expression via the p53 / miR-34a axis ."
34824671
USP29 increases the amount of SIRT1.
| 2
USP29 increases the amount of SIRT1. 2 / 2
| 2
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"Finally, we explored the possible mechanism through which USP29 modulated SIRT1 expression."
34824671
reach
"In view of the fact that USP29 is a deubiquitinase and modulates the downstream targets via catalyzing the removal of monoubiquitin or polyubiquitin chains at the posttranscriptional level, therefore, we speculated that SIRT1 expression was not directly modulated by USP29."
34824671
USP29 decreases the amount of SIRT1.
| 2
USP29 decreases the amount of SIRT1. 2 / 2
| 2
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"Based on these results, we demonstrate that USP29 inhibits SIRT1 expression via the p53/miR-34a axis."
34824671
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"As shown in Figures 4(a)–4(d), USP29 inhibition did not affect cerebral SIRT3 expression upon I/R injury but restored cerebral I/R-induced downregulation of SIRT1, while USP29 overexpression further decreased SIRT1 expression in I/R-injured brains."
34824671
USP29 activates SIRT1.
| 2
USP29 activates SIRT1. 2 / 2
| 2
eidos
"In view of the fact that USP29 is a deubiquitinase and modulates the downstream targets via catalyzing the removal of monoubiquitin or polyubiquitin chains at the posttranscriptional level , therefore , we speculated that SIRT1 expression was not directly modulated by USP29 ."
34824671
eidos
"USP29 Inhibits SIRT1 Expression via p53 / miR-34a Axis Finally , we explored the possible mechanism through which USP29 modulated SIRT1 expression ."
34824671
USP29 affects TP53
1 1 | 6
USP29 deubiquitinates TP53.
1 | 2
USP29 deubiquitinates TP53. 3 / 3
1 | 2
ubibrowser
"Review"
28801249
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"USP29 can also deubiquitinate p53 in response to oxidative stress."
26734569
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"USP29 is transcriptionally activated following oxidative stress and then mediates p53 deubiquitination."
23151129
USP29 binds TP53.
1 | 1
TP53 binds USP29. 2 / 2
1 | 1
biogrid
No evidence text available
21285945
reach
"In response to oxidative stress, USP29 binds to and stabilizes p53."
27516771
USP29 activates TP53.
| 2
USP29 activates TP53. 2 / 2
| 2
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"This is also consistent with the observations that human USP29 might modulate the protein levels of p53 [XREF_BIBR]."
27327533
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"During stress, USP29 removes the polyubiquitin chain from p53 thus stabilizing it and induces p53 dependent apoptosis."
29479529
USP29 increases the amount of TP53.
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USP29 increases the amount of TP53. 1 / 1
| 1
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"Moreover, we found that p53 expression was decreased in UKO mice and further increased by USP29 overexpression upon cerebral I/R injury (Figures 6(c) and 6(d))."
34824671
USP29 activates Reperfusion Injury.
| 6
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"Collectively, these findings imply that USP29 potentiates I/R-induced oxidative damage and neuronal apoptosis in vitro."
34824671
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"USP29 Potentiates I/R-Induced Oxidative Damage and Neuronal Apoptosis In Vitro."
34824671
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"USP29 Inhibition Prevents Cerebral I/R Injury in Mice."
34824671
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"The findings enable us to believe that USP29 inhibition prevents cerebral I/R injury in mice."
34824671
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"USP29 Inhibition Diminishes Cerebral I/R-Induced Oxidative Stress and Apoptosis."
34824671
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"Our previous study identified a protective effect of SIRT3 against cerebral I/R injury; therefore, we investigated whether USP29 inhibition prevented cerebral I/R injury through upregulating SIRT3 [28]."
34824671
USP29 inhibits Reperfusion Injury.
| 1
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"These data suggest that knocking down the endogenous USP29 is sufficient to diminish cerebral I/R-induced oxidative stress and apoptosis."
34824671
USP29 affects Mice
| 7
USP29 activates Mice.
| 5
USP29 activates Mice. 5 / 5
| 5
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"The findings enable us to believe that USP29 inhibition prevents cerebral I/R injury in mice."
34824671
reach
"Accordingly, USP29 overexpression-induced SIRT1 inhibition was prevented in mice treated with either PFT-α or miR-34a antagomir (Figure 6(k))."
34824671
reach
"Systemic knockout of Usp29 depleted MYC and HIF1α in MYC-driven neuroblastoma and B cell lymphoma, inhibited critical metabolic targets and significantly prolonged survival of tumor-bearing mice."
34601505
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"And USP29 overexpression also significantly promoted MDA generation in I/R mice (Figure 3(h))."
34824671
reach
"Based on the above results, we conclude that USP29 upregulation during cerebral I/R injury potentiates oxidative stress, apoptosis, and neurological dysfunction in mice."
34824671
USP29 inhibits Mice.
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USP29 inhibits Mice. 2 / 2
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"Therefore, we tried to clarify whether BMAL1 is required for SIRT1-mediated cerebroprotection in USP29-suppressed mice."
34824671
reach
"In addition, SIRT1 activity was increased in USP29-suppressed mice but further decreased in USP29-overexpressed mice (Figure 4(e))."
34824671
SNAI1 affects USP29
| 2 5
SNAI1 binds USP29. 7 / 7
| 2 5
sparser
"Considering the pivotal roles that Snail1 plays during the development of resistance to chemotherapies, we posited that the USP29-Snail1 axis might be exploited by cancer cells in their acquisition of chemoresistance."
32968046
sparser
"USP29 interacts with Snail1 and requires catalytic activity to stabilize Snail1."
32968046
reach
"These observations imply the necessity of USP29 DUB activity in the regulation of Snail1, but the exact roles of USP29 mutations detected in cancer samples require further clarification.To evaluate the interaction between Snail1 and USP29, we carried out a series of co-immunoprecipitation experiments."
32968046
sparser
"We then moved to investigate the potential interaction between USP29 and Snail1."
32968046
sparser
"Cancer cells hijack the USP29-Snail1 axis to facilitate chemoresistance."
32968046
sparser
"To evaluate the interaction between Snail1 and USP29, we carried out a series of co-immunoprecipitation experiments."
32968046
reach
"We then moved to investigate the potential interaction between USP29 and Snail1."
32968046
USP29 affects cellular antiviral responses
| 6
USP29 activates cellular antiviral responses. 6 / 6
| 6
eidos
"These data collectively suggest that USP29 deficiency restricts cellular antiviral responses against HSV-1 ."
32457395
eidos
"USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity Cyclic GMP-AMP synthase ( cGAS ) is an essential sensor of cytosolic DNA and critically mediates innate immune responses and autoimmunity ."
32457395
eidos
"These data suggest that USP29 promotes cellular antiviral responses in a manner dependent on its DUB activity ."
32457395
eidos
"USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity ."
32457395
eidos
"Author Correction : USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity ."
32632253
eidos
"Author Correction : USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity Correction to : Cell Research 10.1038 / s41422-020-0341-6 , published online 26 May 2020 We just found several mistakes and typos in the paper published on May 26 , 2020 ."
32632253
USP29 affects E7
4 | 2
USP29 binds E7. 2 / 2
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virhostnet
No evidence text available
28786561
virhostnet
No evidence text available
28786561
USP29 binds USP33 and E7. 2 / 2
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sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
USP29 binds E7. 1 / 1
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virhostnet
No evidence text available
28786561
USP29 binds E7. 1 / 1
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virhostnet
No evidence text available
28786561
AIMP2 affects USP29
| 5 1
AIMP2 activates USP29.
| 3 1
AIMP2 activates USP29. 4 / 4
| 3 1
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"Knockdown of parkin increased the level of AIMP2, leading to ultimately USP29 and MYBBP1A accumulation in SH-SY5Y cells."
31878357
sparser
"In addition, a recent study revealed that AIMP2–FBP1 complex transcriptionally activates USP29 in oxidative conditions [ xref ]."
31878357
reach
"These results suggest that AIMP2 upregulates USP29 and MYBBP1A in the absence of parkin activity, contributing to PD pathogenesis."
31878357
reach
"USP29 is induced by JTV1 and FBP driven transcription in response to oxidative stress, and was also shown to be important for the full activation of PUMA and apoptosis [XREF_BIBR]."
24143256
AIMP2 increases the amount of USP29.
| 2
AIMP2 increases the amount of USP29. 2 / 2
| 2
reach
"USP29 is expressed by JTV1 and FBP transcriptional factors."
| PMC
reach
"JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress."
21285945
USP29 affects KMT5A
| 4 1
USP29 deubiquitinates KMT5A.
| 2
USP29 deubiquitinates KMT5A. 2 / 2
| 2
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"Wildtype USP29 can deubiquitinate SETD8 in vivo, indicating that USP29 directly regulates SETD8 protein levels."
36010569
reach
"USP29 Deubiquitinates SETD8 and Regulates DNA Damage-Induced H4K20 Monomethylation and 53BP1 Focus Formation."
36010569
USP29 binds KMT5A.
| 1 1
USP29 binds KMT5A. 2 / 2
| 1 1
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"We demonstrate that SETD8 binds to USP29 in vivo, and this interaction is dependent on the catalytic activity of USP29."
36010569
sparser
"We demonstrate that SETD8 binds to USP29 in vivo, and this interaction is dependent on the catalytic activity of USP29."
36010569
USP29 increases the amount of KMT5A.
| 1
USP29 increases the amount of KMT5A. 1 / 1
| 1
reach
"Wildtype USP29 can deubiquitinate SETD8 in vivo, indicating that USP29 directly regulates SETD8 protein levels."
36010569
USP29 affects IFNB1
| 5
USP29 increases the amount of IFNB1.
| 2
USP29-C298A increases the amount of IFNB1. 1 / 1
| 1
reach
"XREF_FIG, reconstitution of wild-type USP29 but not the inactive mutant USP29 (C298A) into Usp29 m/m MLFs fully restored the expression of Ifnb, Ifna4, Tnf, or Il6."
32457395
USP29 increases the amount of IFNB1. 1 / 1
| 1
reach
"XREF_FIG, reconstitution of wild-type USP29 but not the inactive mutant USP29 (C298A) into Usp29 m/m MLFs fully restored the expression of Ifnb, Ifna4, Tnf, or Il6."
32457395
USP29 decreases the amount of IFNB1.
| 2
USP29 decreases the amount of IFNB1. 2 / 2
| 2
reach
"Interestingly, we found that knockdown of USP29 significantly impaired various cytoplasmic DNA induced expression of IFNB, TNF, and IP10 but had little effect on cGAMP induced expression of IFNB, TNF, and IP10."
32457395
reach
"Knockdown of USP29 by these two shRNAs significantly inhibited HSV-1-induced expression of IFNB, TNF, IL6, and IP10 in THP-1 cells (The # 2 shRNA was used for the following experiments and similar results were observed with # 1 shRNA)."
32457395
USP29 activates IFNB1.
| 1
USP29 activates IFNB1. 1 / 1
| 1
reach
"In addition, knockdown of USP29 significantly impaired the production of IFN-beta, IFN-alpha, IL-6, and TNF after infection of HSV-1 or transfection of various DNA ligands."
32457395
HIF1 affects USP29
| 5
HIF1 binds USP29.
| 2
HIF1 binds USP29. 2 / 2
| 2
reach
"Indeed, we found that USP29 binds HIF1α in both Huh7-IR and Huh7-CR Sorafenib-resistant cells (Fig. 3a, b)."
34272356
reach
"To this end, we first examined a physical interaction between USP29 and HIF1α."
34272356
HIF1 activates USP29.
| 2
HIF1 activates USP29. 2 / 2
| 2
reach
"However, upon siRNA-mediated depletion of USP29, the loss of HIF1α protein was substantially accelerated, further supporting the key role of USP29 in stabilizing HIF1α."
34272356
reach
"Immunohistochemical staining of USP29 and HIF1α on tumor sections confirmed that the siRNA-mediated knockdown of USP29 not only efficiently depleted USP29 but also reduced HIF1α levels (Fig. 6d)."
34272356
HIF1 inhibits USP29.
| 1
HIF1 inhibits USP29. 1 / 1
| 1
reach
"However, upon siRNA-mediated depletion of USP29, the loss of HIF1α protein was substantially accelerated, further supporting the key role of USP29 in stabilizing HIF1α."
34272356
CLSPN affects USP29
2 | 1 1
USP29 binds CLSPN. 4 / 5
2 | 1 1
reach
"USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro."
24632611
biogrid
No evidence text available
24632611
trips
"USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro."
24632611
biogrid
No evidence text available
24632611
USP29 affects polyubiquitin chains
| 3 1
USP29 inhibits polyubiquitin chains. 4 / 4
| 3 1
eidos
"Because USP29 interacts with cGAS and its enzyme activity is required for regulating antiviral signaling , we investigated whether USP29 eliminated polyubiquitin chains from cGAS ."
32457395
eidos
"whether USP29 eliminated polyubiquitin chains from cGAS ."
32457395
eidos
"USP29 deubiquitinates cGAS in the presence or absence of HSV-1 infection Because USP29 interacts with cGAS and its enzyme activity is required for regulating antiviral signaling , we investigated whether USP29 eliminated polyubiquitin chains from cGAS ."
32457395
reach
"Because USP29 interacts with cGAS and its enzyme activity is required for regulating antiviral signaling, we investigated whether USP29 eliminated polyubiquitin chains from cGAS."
32457395
Infections affects USP29
| 4
Infections activates USP29. 4 / 4
| 4
eidos
"39 , 42 USP29 promotes HSV-1-triggered innate antiviral signaling in THP-1 cells Because USP29 interacted with cGAS and was upregulated by HSV-1 infection , we investigated its role in regulating HSV-1-or cytoplasmic DNA-triggered innate immune signaling ."
32457395
eidos
"Sequence analysis of USP29 promoter ( -5000 bp ~ +100 bp ) failed to identify any recognizable IRF , NF-kappaB , or STAT binding sites , indicating that the transcriptional regulation of USP29 by viral infection is different from that of OTUD4 , USP25 or INKIT previously reported.37 ,40,41 In this context , it has been shown that transcription factors JTV1 and FBP co-activate USP29 transcription in response to oxidative stress and that one of the evolutionarily conserved sequence elements ( CSE1 ) on Usp29 promoter suppresses its transcription.39 ,42 Because USP29 interacted with cGAS and was upregulated by HSV-1 infection , we investigated its role in regulating HSV-1 - or cytoplasmic DNA-triggered innate immune signaling ."
32457395
eidos
"Sequence analysis of USP29 promoter ( -5000 bp ~ +100 bp ) failed to identify any recognizable IRF , NF-kappaB , or STAT binding sites , indicating that the transcriptional regulation of USP29 by viral infection is different from that of OTUD4 , USP25 or INKIT previously reported.37 ,40,41 In this context , it has been shown that transcription factors JTV1 and FBP co-activate USP29 transcription in response to oxidative stress and that one of the evolutionarily conserved sequence elements ( CSE1 ) on Usp29 promoter suppresses its transcription.39 ,42 USP29 promotes HSV-1-triggered innate antiviral signaling in THP-1 cells Because USP29 interacted with cGAS and was upregulated by HSV-1 infection , we investigated its role in regulating HSV-1 - or cytoplasmic DNA-triggered innate immune signaling ."
32457395
eidos
"Our results suggest that HSV-1 infection upregulated USP29 , which might be responsible for increased USP29-cGAS association after HSV-1 infection ."
32457395
Pirinixic acid affects USP29
3 |
Pirinixic acid decreases the amount of USP29.
2 |
Pirinixic acid decreases the amount of USP29. 2 / 2
2 |
ctd
No evidence text available
23811191
ctd
No evidence text available
19710929
Pirinixic acid activates USP29.
1 |
ctd
No evidence text available
19710929
CGAS affects USP25
| 3
USP25 binds USP29 and cGAS. 3 / 3
| 3
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established, xref – xref and found that USP25 and USP29 interacted with cGAS in such a system (Fig.  xref )."
32457395
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established, [35] [36] [37] and found that USP25 and USP29 interacted with cGAS in such a system (Fig. 1a) ."
32457395
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established,35–37 and found that USP25 and USP29 interacted with cGAS in such a system (Fig. 1a)."
32457395
USP29 affects cerebral R injury
| 3
USP29 activates cerebral R injury. 3 / 3
| 3
eidos
"Generally , our findings for the first time identify that USP29 upregulation during cerebral I / R may contribute to oxidative stress , neuronal apoptosis , and the progression of cerebral I / R injury and that inhibition of USP29 may help to develop novel therapeutic strategies to treat cerebral I / R injury ."
34824671
eidos
"Our findings for the first time identify that USP29 upregulation during cerebral I / R may contribute to oxidative stress , neuronal apoptosis , and the progression of cerebral I / R injury and that inhibition of USP29 may help to develop novel therapeutic strategies to treat cerebral I / R injury ."
34824671
eidos
"Our previous study identified a protective effect of SIRT3 against cerebral I / R injury ; therefore , we investigated whether USP29 inhibition prevented cerebral I / R injury through upregulating SIRT3 [ 28 ] ."
34824671
USP29 activates cell population proliferation. 3 / 3
| 1 2
eidos
"USP29 depletion produced a pronounced decrease in cell proliferation compared with the scrambled sgRNA control ( p = 0.0189 ) ( Figure 4B ) ."
34072621
reach
"After transfection of si-USP29, the proliferation of CRC cells was evaluated by the cell counting kit-8, colony formation and 5-ethynyl-2'-deoxyuridine assays, and we observed that depletion of USP29 inhibited the proliferation of CRC cells."
36373629
reach
"USP29 knockdown significantly decreased CRC cell proliferation in vitro."
34072621
USP29 affects cell migration
| 1 2
USP29 activates cell migration. 3 / 3
| 1 2
reach
"Biologically, ectopic expression of USP29 promotes gastric cancer cell migration, and depletion of Snail abolishes USP29 mediated cell migration; and USP29 can be induced by major EMT and metastatic inducing factors such as TGFbeta, TNFalpha, and hypoxia."
32973332
eidos
"Collectively , these data indicate that Snail is a crucial substrate for USP29 to promote cell migration and USP29 / SCP1 complex may be new therapeutic targets to treat metastatic cancer ."
32973332
reach
"Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein."
32973332
USP29 affects USP25
| 3
USP25 binds USP29 and cGAS. 3 / 3
| 3
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established, xref – xref and found that USP25 and USP29 interacted with cGAS in such a system (Fig.  xref )."
32457395
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established, [35] [36] [37] and found that USP25 and USP29 interacted with cGAS in such a system (Fig. 1a) ."
32457395
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established,35–37 and found that USP25 and USP29 interacted with cGAS in such a system (Fig. 1a)."
32457395
USP29 affects TRIM38
| 3
TRIM38 binds USP29. 2 / 2
| 2
sparser
"Interestingly, we found that TRIM38 constitutively interacts with cGAS but not with USP29, whereas USP29 constitutively interacts with cGAS but not with TRIM38 (Supplementary information, Fig. S2h), indicating that TRIM38 and USP29 independently interacts with and regulates cGAS."
32457395
sparser
"Interestingly, we found that TRIM38 constitutively interacts with cGAS but not with USP29, whereas USP29 constitutively interacts with cGAS but not with TRIM38 (Supplementary information, Fig.  xref ), indicating that TRIM38 and USP29 independently interacts with and regulates cGAS."
32457395
TRIM38 binds USP29 and cGAS. 1 / 1
| 1
sparser
"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38-mediated sumoylation and USP29-mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
USP29 affects TNF
| 3
USP29 decreases the amount of TNF.
| 2
USP29 decreases the amount of TNF. 2 / 2
| 2
reach
"Interestingly, we found that knockdown of USP29 significantly impaired various cytoplasmic DNA induced expression of IFNB, TNF, and IP10 but had little effect on cGAMP induced expression of IFNB, TNF, and IP10."
32457395
reach
"Knockdown of USP29 by these two shRNAs significantly inhibited HSV-1-induced expression of IFNB, TNF, IL6, and IP10 in THP-1 cells (The # 2 shRNA was used for the following experiments and similar results were observed with # 1 shRNA)."
32457395
USP29 activates TNF.
| 1
USP29 activates TNF. 1 / 1
| 1
reach
"In addition, knockdown of USP29 significantly impaired the production of IFN-beta, IFN-alpha, IL-6, and TNF after infection of HSV-1 or transfection of various DNA ligands."
32457395
USP29 affects Neoplasms
| 1 2
USP29 activates Neoplasms. 3 / 3
| 1 2
eidos
"In conclusion , our study shows that elevated expression of USP29 promotes malignancy in CRC , suggesting that USP29 could be a promising target for colon cancer therapy ."
34072621
reach
"Such tumor-promoting effects of USP29 were experimentally validated through a series of in vitro and in vivo phenotypic assays, with several lines of evidence in support of the notion that USP29 expression positively correlated with the enhanced stemness of lung adenocarcinoma cells.It is intriguing that certain labile transcription factors can be stabilized by diverse DUBs, with p53 showing a leading example."
32968046
reach
"Systemic knockout of Usp29 depleted MYC and HIF1α in MYC-driven neuroblastoma and B cell lymphoma, inhibited critical metabolic targets and significantly prolonged survival of tumor-bearing mice."
34601505
USP29 affects MYBBP1A
| 3
USP29 binds MYBBP1A. 3 / 3
| 3
sparser
"To confirm whether USP29 binds to MYBBP1A, Flag-tagged MYBBP1A and HA-tagged USP29 were co-transfected into SH-SY5Y cells and Flag-tagged MYBBP1A was immunoprecipitated, showing that Flag-MYBBP1A pulled down HA-USP29 ( xref B)."
31878357
sparser
"USP29 Binds to MYBBP1A."
31878357
sparser
"We observed that there was no brain-region-specific interaction between USP29 and MYBBP1A, indicating that MYBBP1A might be an authentic physiological substrate of USP29 ( xref E)."
31878357
USP29 affects K48
| 3
USP29 binds CGAS and K48. 3 / 3
| 3
reach
"Mechanistically, USP29 constitutively interacts with cGAS, deconjugates K48 linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection."
32457395
reach
"[208] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48 linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV-1 stimulation."
33511009
reach
"USP29 constitutively interacts with cGAS and deconjugates K48 linked polyubiquitin chains from cGAS in the absence or presence of HSV-1 infection, which stabilizes cGAS and promotes cGAS mediated cellular antiviral responses."
32457395
USP29 affects HIF1A
| 3
USP29 deubiquitinates HIF1A.
| 1
USP29 deubiquitinates HIF1A. 1 / 1
| 1
reach
"USP29 interacts with and deubiquitylates HIF1alpha."
34272356
USP29 binds HIF1A.
| 1
USP29 binds HIF1A. 1 / 1
| 1
reach
"USP29 interacts with and deubiquitylates HIF1alpha."
34272356
USP29 activates HIF1A.
| 1
USP29 activates HIF1A. 1 / 1
| 1
reach
"USP29-mediated HIF1alpha stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis."
34272356
USP29 affects HIF1
| 3
USP29 binds HIF1.
| 2
HIF1 binds USP29. 2 / 2
| 2
reach
"Indeed, we found that USP29 binds HIF1α in both Huh7-IR and Huh7-CR Sorafenib-resistant cells (Fig. 3a, b)."
34272356
reach
"To this end, we first examined a physical interaction between USP29 and HIF1α."
34272356
USP29 deubiquitinates HIF1.
| 1
USP29 leads to the deubiquitination of HIF1. 1 / 1
| 1
reach
"The removal of ubiquitin on HIF1α seemed to be directly catalyzed by USP29, since a catalytically inactive form of USP29 (CA) failed to reduce ubiquitination of HIF1α (Fig. 3d) and, as a consequence, the CA form of USP29 was unable to stabilize HIF1α."
34272356
USP29 affects Carcinogenesis
| 1 2
USP29 activates Carcinogenesis. 3 / 3
| 1 2
reach
"USP29 upregulation enhances the cancer stem cell-like characteristics in lung adenocarcinoma cells to promote tumorigenesis in athymic nude mice."
32968046
reach
"USP29 is a member of the USP family and functions as an oncogene to promote tumorigenesis in some human tumors."
34824671
eidos
"USP29 is a member of the USP family and functions as an oncogene to promote tumorigenesis in some human tumors ."
34824671
USP29 affects CDC25A
| 1 2
USP29 binds CDC25A.
| 2
CDC25A binds USP29. 2 / 2
| 2
sparser
"To further investigate the physical association of Cdc25A and USP29, HEK293 cells were co-transfected with Myc-Cdc25A and GFP-USP29 and subjected to immunoprecipitation with anti-Myc or -GFP antibodies, followed by Western blotting with reciprocal antibodies."
34071237
sparser
"Thus, our data indicated that Cdc25A and USP29 bound to each other and were co-localized."
34071237
USP29 deubiquitinates CDC25A.
| 1
USP29 leads to the deubiquitination of CDC25A. 1 / 1
| 1
reach
"The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life."
34071237
USP29 affects Autoimmunity
| 3
USP29 activates Autoimmunity.
| 2
USP29 activates Autoimmunity. 2 / 2
| 2
eidos
"Author Correction : USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity ."
32632253
eidos
"USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity ."
32457395
USP29 inhibits Autoimmunity.
| 1
USP29 inhibits Autoimmunity. 1 / 1
| 1
eidos
"USP29 deficiency alleviates autoimmunity in Trex1 - / - mice Consistent with the results obtained with USP29 knockout cells , we found that the protein levels of cGAS were substantially lower in various organs such as heart , liver , kidney and spleen from Usp29m / m mice than in those from Usp29 + / + mice ( Fig. 7a ) ."
32457395
USP25 affects cGAS
| 3
USP25 binds USP29 and cGAS. 3 / 3
| 3
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established, xref – xref and found that USP25 and USP29 interacted with cGAS in such a system (Fig.  xref )."
32457395
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established, [35] [36] [37] and found that USP25 and USP29 interacted with cGAS in such a system (Fig. 1a) ."
32457395
sparser
"To test this hypothesis, we conducted an unbiased screening of cGAS-interacting DUBs by cotransfection and immunoprecipitation assays as previous established,35–37 and found that USP25 and USP29 interacted with cGAS in such a system (Fig. 1a)."
32457395
TRIM38 affects USP29
| 3
TRIM38 binds USP29. 2 / 2
| 2
sparser
"Interestingly, we found that TRIM38 constitutively interacts with cGAS but not with USP29, whereas USP29 constitutively interacts with cGAS but not with TRIM38 (Supplementary information, Fig. S2h), indicating that TRIM38 and USP29 independently interacts with and regulates cGAS."
32457395
sparser
"Interestingly, we found that TRIM38 constitutively interacts with cGAS but not with USP29, whereas USP29 constitutively interacts with cGAS but not with TRIM38 (Supplementary information, Fig.  xref ), indicating that TRIM38 and USP29 independently interacts with and regulates cGAS."
32457395
TRIM38 binds USP29 and cGAS. 1 / 1
| 1
sparser
"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38-mediated sumoylation and USP29-mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
USP29 is modified
1 | 1 1
USP29 is phosphorylated.
1 | 1
USP29 is phosphorylated on S585. 1 / 1
1 |
hprd
No evidence text available
18491316
USP29 is phosphorylated. 1 / 1
| 1
sparser
"Mechanistically, CDK1-mediated phosphorylation of USP29 is essential for its deubiquitinase activity toward TWIST1 and TWIST1 driven-malignant phenotypes in TNBC, which could be markedly mitigated by the genetic ablation or pharmacological inhibition of CDK1."
36782089
USP29 is sumoylated.
| 1
USP29 is sumoylated. 1 / 1
| 1
reach
"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38 mediated sumoylation and USP29 mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
MYBBP1A affects USP29
| 3
USP29 binds MYBBP1A. 3 / 3
| 3
sparser
"To confirm whether USP29 binds to MYBBP1A, Flag-tagged MYBBP1A and HA-tagged USP29 were co-transfected into SH-SY5Y cells and Flag-tagged MYBBP1A was immunoprecipitated, showing that Flag-MYBBP1A pulled down HA-USP29 ( xref B)."
31878357
sparser
"USP29 Binds to MYBBP1A."
31878357
sparser
"We observed that there was no brain-region-specific interaction between USP29 and MYBBP1A, indicating that MYBBP1A might be an authentic physiological substrate of USP29 ( xref E)."
31878357
K48 affects USP29
| 3
USP29 binds CGAS and K48. 3 / 3
| 3
reach
"Mechanistically, USP29 constitutively interacts with cGAS, deconjugates K48 linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection."
32457395
reach
"[208] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48 linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV-1 stimulation."
33511009
reach
"USP29 constitutively interacts with cGAS and deconjugates K48 linked polyubiquitin chains from cGAS in the absence or presence of HSV-1 infection, which stabilizes cGAS and promotes cGAS mediated cellular antiviral responses."
32457395
FBP1 affects USP29
| 2 1
FBP1 activates USP29.
| 1 1
FBP1 activates USP29. 2 / 2
| 1 1
reach
"It will be interesting to examine whether DX2 also competes with AIMP2 and p38 for binding to FBP1 and inhibits FBP1 mediated induction of USP29, which in turn, may have destabilizing effect on p53."
25487856
sparser
"In addition, a recent study revealed that AIMP2–FBP1 complex transcriptionally activates USP29 in oxidative conditions [ xref ]."
31878357
FBP1 increases the amount of USP29.
| 1
FBP1 increases the amount of USP29. 1 / 1
| 1
reach
"FBP1 promotes transcription of the USP29 gene through binding to FUSE."
22926519
CGAS affects K48, and USP29
| 3
USP29 binds CGAS and K48. 3 / 3
| 3
reach
"Mechanistically, USP29 constitutively interacts with cGAS, deconjugates K48 linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection."
32457395
reach
"[208] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48 linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV-1 stimulation."
33511009
reach
"USP29 constitutively interacts with cGAS and deconjugates K48 linked polyubiquitin chains from cGAS in the absence or presence of HSV-1 infection, which stabilizes cGAS and promotes cGAS mediated cellular antiviral responses."
32457395
CDK1 affects USP29
| 1 2
CDK1 phosphorylates USP29.
| 1 1
CDK1 phosphorylates USP29. 2 / 2
| 1 1
reach
"Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions."
36782089
sparser
"Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions."
36782089
CDK1 binds USP29.
| 1
CDK1 binds USP29. 1 / 1
| 1
sparser
"Taken together, the findings reveal a previously unrecognized tumor-promoting function and clinical significance of the CDK1-USP29 axis through stabilizing TWIST1 and provide the preclinical evidence that targeting this axis is an appealing therapeutic strategy to conquer chemo-resistance and metastasis in TNBC."
36782089
Treatment IFNs affects USP29
| 2
Treatment IFNs activates USP29. 2 / 2
| 2
eidos
"or Poly ( I :C ) or treatment of type I IFNs did not induce upregulation of USP29 ."
32457395
eidos
"Interestingly , SeV infection , transfection of dsDNA or Poly ( I :C ) or treatment of type I IFNs did not induce upregulation of USP29 ."
32457395
Epithelial to mesenchymal transition activates USP29. 2 / 2
| 1 1
reach
"Biologically, ectopic expression of USP29 promotes gastric cancer cell migration, and depletion of Snail abolishes USP29 mediated cell migration; and USP29 can be induced by major EMT and metastatic inducing factors such as TGFbeta, TNFalpha, and hypoxia."
32973332
eidos
"Biologically , ectopic expression of USP29 promotes gastric cancer cell migration , and depletion of Snail abolishes USP29-mediated cell migration ; and USP29 can be induced by major EMT and metastatic inducing factors such as TGFbeta , TNFalpha , and hypoxia ."
32973332
ZEB1 affects USP29
2 |
ZEB1 binds USP29. 2 / 2
2 |
biogrid
No evidence text available
29119051
biogrid
No evidence text available
29119051
VIRMA affects USP29
| 2
VIRMA inhibits USP29.
| 1
VIRMA inhibits USP29. 1 / 1
| 1
reach
"Moreover, overexpression of KIAA1429 or SOX8 reversed the inhibitory effects of USP29 depletion on CRC cell proliferation."
36373629
VIRMA binds USP29.
| 1
USP29 binds VIRMA. 1 / 1
| 1
reach
"Co-immunoprecipitation confirmed the binding of USP29 to KIAA1429."
36373629
USP33 affects USP29
| 2
USP29 binds USP33 and E7. 2 / 2
| 2
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
USP29 affects sorafenib
| 2
USP29 activates sorafenib. 2 / 2
| 2
reach
"Together, the data demonstrate that, as a DUB of HIF1alpha, USP29 promotes Sorafenib resistance in HCC cells, in parts by upregulating glycolysis, thereby opening new avenues for therapeutically targeting Sorafenib-resistant HCC in patients."
34272356
reach
"USP29 promotes sorafenib resistance in vivo."
34272356
USP29 affects neuronal apoptosis
| 2
USP29 activates neuronal apoptosis. 2 / 2
| 2
eidos
"Our findings for the first time identify that USP29 upregulation during cerebral I / R may contribute to oxidative stress , neuronal apoptosis , and the progression of cerebral I / R injury and that inhibition of USP29 may help to develop novel therapeutic strategies to treat cerebral I / R injury ."
34824671
eidos
"Generally , our findings for the first time identify that USP29 upregulation during cerebral I / R may contribute to oxidative stress , neuronal apoptosis , and the progression of cerebral I / R injury and that inhibition of USP29 may help to develop novel therapeutic strategies to treat cerebral I / R injury ."
34824671
USP29 affects immune response
| 2
USP29 activates immune response. 2 / 2
| 2
reach
"To further substantiate our conclusion that USP29 positively regulates antiviral immunity by stabilizing cGAS, we reconstituted an empty vector or cGAS into Usp29 +/+ or Usp29 m/m MLFs and examined HSV-1-triggered signaling in these cells."
32457395
reach
"46 In this study, we demonstrated that USP29 deconjugated K48 linked polyubiquitin chains from K271 of cGAS in resting cells or after HSV-1 infection, which stabilized cGAS to produce cGAMP and activate MITA mediated antiviral immunity as well as autoimmunity (Supplementary information, FigS7e)."
32457395
USP29 inhibits glycolytic process.
| 1
USP29 inhibits glycolytic process. 1 / 1
| 1
reach
"The absence of USP29, and thus of HIF1alpha transcriptional activity, reduces the levels of aerobic glycolysis and restores sensitivity to Sorafenib in Sorafenib-resistant HCC cells in vitro and in xenograft transplantation mouse models in vivo."
34272356
USP29 activates glycolytic process.
| 1
USP29 activates glycolytic process. 1 / 1
| 1
reach
"Depletion of USP29 significantly reduces glycolysis and lactate production."
34272356
USP29 affects colony
| 2
USP29 activates colony. 2 / 2
| 2
eidos
"USP29 depletion produced a significant reduction in colony numbers compared with the scrambled sgRNA control ( p = 0.0073 ) , and reconstitution of USP29 increased the colony numbers compared with the USP29-depleted group ( p = 0.0353 ) ( Figure 4C ) ."
34072621
eidos
"We also demonstrated that USP29 depletion hampers the colony formation and increases apoptosis of HCT116 cells ."
34072621
USP29 affects cell
| 2
USP29 inhibits cell.
| 1
USP29 inhibits cell. 1 / 1
| 1
eidos
"The absence of USP29 , and thus of HIF1alpha transcriptional activity , reduces the levels of aerobic glycolysis and restores sensitivity to Sorafenib in Sorafenib-resistant HCC cells in vitro and in xenograft transplantation mouse models in vivo ."
34272356
USP29 activates cell.
| 1
USP29 activates cell. 1 / 1
| 1
eidos
"USP29 knockdown significantly decreased CRC cell proliferation in vitro ."
34072621
USP29 affects ZEB1
2 |
ZEB1 binds USP29. 2 / 2
2 |
biogrid
No evidence text available
29119051
biogrid
No evidence text available
29119051
USP29 affects VIRMA
| 2
USP29 increases the amount of VIRMA.
| 1
USP29 increases the amount of VIRMA. 1 / 1
| 1
reach
"Mechanically, USP29 mediated deubiquitination to stabilize the protein levels of KIAA1429, and KIAA1429 promoted the stability of SOX8 mRNA through m6A modification."
36373629
USP29 binds VIRMA.
| 1
USP29 binds VIRMA. 1 / 1
| 1
reach
"Co-immunoprecipitation confirmed the binding of USP29 to KIAA1429."
36373629
USP29 affects USP33
| 2
USP29 binds USP33 and E7. 2 / 2
| 2
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
USP29 affects TREX1
| 2
USP29 inhibits TREX1.
| 1
USP29 inhibits TREX1. 1 / 1
| 1
reach
"In addition, knockout of USP29 in Trex1 -/- background rescued developmental retardation of Trex1 -/- mice."
32457395
USP29 activates TREX1.
| 1
USP29 activates TREX1. 1 / 1
| 1
reach
"Consistently, knockout of USP29 results in constitutive degradation of cGAS and eliminates the autoimmune phenotypes in Trex1 -/- mice."
32457395
USP29 affects Oxidative Stress
| 2
eidos
"Our findings for the first time identify that USP29 upregulation during cerebral I / R may contribute to oxidative stress , neuronal apoptosis , and the progression of cerebral I / R injury and that inhibition of USP29 may help to develop novel therapeutic strategies to treat cerebral I / R injury ."
34824671
eidos
"Generally , our findings for the first time identify that USP29 upregulation during cerebral I / R may contribute to oxidative stress , neuronal apoptosis , and the progression of cerebral I / R injury and that inhibition of USP29 may help to develop novel therapeutic strategies to treat cerebral I / R injury ."
34824671
USP29 affects OGD/R
| 2
USP29 activates OGD/R. 2 / 2
| 2
reach
"As shown in Figure S1A-B, the survival was decreased, while LDH releases were enhanced in the primary cortical neurons upon OGD/R stimulation, which were attenuated by USP29 silence."
34824671
reach
"We also found that USP29 knockdown significantly suppressed OGD/R-induced increases of caspase-3 activity (Figure S1C)."
34824671
USP29 affects NFKBIA
| 2
USP29 leads to the phosphorylation of NFKBIA. 1 / 1
| 1
reach
"In addition, the production of IFN-beta or TNF and phosphorylation of IRF3 and IkappaBalpha was rescued by reconstitution of USP29 but not USP29 (C298A) into Usp29 m/m MLFs."
32457395
USP29-C298A leads to the phosphorylation of NFKBIA. 1 / 1
| 1
reach
"In addition, the production of IFN-beta or TNF and phosphorylation of IRF3 and IkappaBalpha was rescued by reconstitution of USP29 but not USP29 (C298A) into Usp29 m/m MLFs."
32457395
USP29 affects MKI67
| 2
USP29 binds MKI67. 1 / 1
| 1
sparser
"Our results showed that USP29 and Ki67 are not binding each other ( xref ), suggesting that the expression of USP29 increases Ki67 expression in colon cancer cells without interacting with Ki67."
34072621
USP29 binds MKI67 and HCT116. 1 / 1
| 1
sparser
"We next checked the interactions between endogenous USP29 and Ki67 in HCT116 cells."
34072621
USP29 affects IRF3
| 2
USP29-C298A leads to the phosphorylation of IRF3. 1 / 1
| 1
reach
"In addition, the production of IFN-beta or TNF and phosphorylation of IRF3 and IkappaBalpha was rescued by reconstitution of USP29 but not USP29 (C298A) into Usp29 m/m MLFs."
32457395
USP29 leads to the phosphorylation of IRF3. 1 / 1
| 1
reach
"In addition, the production of IFN-beta or TNF and phosphorylation of IRF3 and IkappaBalpha was rescued by reconstitution of USP29 but not USP29 (C298A) into Usp29 m/m MLFs."
32457395
USP29 affects IL6
| 2
USP29 decreases the amount of IL6.
| 1
USP29 decreases the amount of IL6. 1 / 1
| 1
reach
"Knockdown of USP29 by these two shRNAs significantly inhibited HSV-1-induced expression of IFNB, TNF, IL6, and IP10 in THP-1 cells (The # 2 shRNA was used for the following experiments and similar results were observed with # 1 shRNA)."
32457395
USP29 activates IL6.
| 1
USP29 activates IL6. 1 / 1
| 1
reach
"In addition, knockdown of USP29 significantly impaired the production of IFN-beta, IFN-alpha, IL-6, and TNF after infection of HSV-1 or transfection of various DNA ligands."
32457395
USP29 affects Death
| 2
USP29 inhibits Death.
| 1
USP29 inhibits Death. 1 / 1
| 1
reach
"As shown in Figure S2A-B, USP29 silence dramatically prevented OGD/R-induced neuronal injury and death, but not in those with siSIRT1 transfection."
34824671
USP29 activates Death.
| 1
USP29 activates Death. 1 / 1
| 1
reach
"As shown in Figure S2A-B, USP29 silence dramatically prevented OGD/R-induced neuronal injury and death, but not in those with siSIRT1 transfection."
34824671
USP29 affects CXCL10
| 2
USP29 decreases the amount of CXCL10. 2 / 2
| 2
reach
"Knockdown of USP29 by these two shRNAs significantly inhibited HSV-1-induced expression of IFNB, TNF, IL6, and IP10 in THP-1 cells (The # 2 shRNA was used for the following experiments and similar results were observed with # 1 shRNA)."
32457395
reach
"Interestingly, we found that knockdown of USP29 significantly impaired various cytoplasmic DNA induced expression of IFNB, TNF, and IP10 but had little effect on cGAMP induced expression of IFNB, TNF, and IP10."
32457395
USP29 affects CRC
| 2
USP29 activates CRC. 2 / 2
| 2
reach
"In conclusion, our study shows that elevated expression of USP29 promotes malignancy in CRC, suggesting that USP29 could be a promising target for colon cancer therapy."
34072621
reach
"USP29 knockdown significantly decreased CRC cell proliferation in vitro."
34072621
USP29 affects CASP3
| 2
USP29 activates CASP3. 2 / 2
| 2
reach
"And SIRT1 knockout also blocked USP29 inhibition-mediated inhibition on caspase-3 activity (Figure 4(l))."
34824671
reach
"We also found that USP29 knockdown significantly suppressed OGD/R-induced increases of caspase-3 activity (Figure S1C)."
34824671
USP29 affects ARNTL
| 2
USP29 decreases the amount of ARNTL.
| 1
USP29 decreases the amount of ARNTL. 1 / 1
| 1
reach
"In addition, SIRT1 knockout significantly blocked USP29 inhibition-mediated upregulation on BMAL1 expression in I/R-injured brains (Figures 5(c) and 5(d))."
34824671
USP29 deacetylates ARNTL.
| 1
USP29 leads to the deacetylation of ARNTL. 1 / 1
| 1
reach
"Mechanistically, neuronal USP29 enhances p53/miR-34a-mediated SIRT1 downregulation and then promotes the acetylation and suppression of BMAL1, thereby aggravating oxidative stress and apoptosis upon cerebral I/R injury (Figure 7)."
34824671
TP53 affects USP29
1 | 1
TP53 binds USP29. 2 / 2
1 | 1
biogrid
No evidence text available
21285945
reach
"In response to oxidative stress, USP29 binds to and stabilizes p53."
27516771
SIRT1 knockout affects USP29
| 2
SIRT1 knockout inhibits USP29. 2 / 2
| 2
eidos
"And SIRT1 knockout also blocked USP29 inhibition-mediated inhibition on caspase-3 activity ( Figure 4 ( l ) ) ."
34824671
eidos
"In addition , SIRT1 knockout significantly blocked USP29 inhibition-mediated upregulation on BMAL1 expression in I / R-injured brains ( Figures 5 ( c ) and 5 ( d ) ) ."
34824671
Oxidative Stress affects USP29
| 2
eidos
"In this context , a previous study has shown that oxidative stress induces JTV1-FBP association to co-activate transcription of USP29.39 Whether and how HSV-1 infection promotes oxidative stress to activate transcription of USP29 requires further investigations ."
32457395
eidos
"USP29 expression could be induced by oxidative stress , which in turn promoted cell apoptosis [ 25 ] ."
34824671
MKI67 affects USP29
| 2
USP29 binds MKI67. 1 / 1
| 1
sparser
"Our results showed that USP29 and Ki67 are not binding each other ( xref ), suggesting that the expression of USP29 increases Ki67 expression in colon cancer cells without interacting with Ki67."
34072621
USP29 binds MKI67 and HCT116. 1 / 1
| 1
sparser
"We next checked the interactions between endogenous USP29 and Ki67 in HCT116 cells."
34072621
KMT5A affects USP29
| 1 1
USP29 binds KMT5A. 2 / 2
| 1 1
reach
"We demonstrate that SETD8 binds to USP29 in vivo, and this interaction is dependent on the catalytic activity of USP29."
36010569
sparser
"We demonstrate that SETD8 binds to USP29 in vivo, and this interaction is dependent on the catalytic activity of USP29."
36010569
FUBP1 affects USP29
| 2
FUBP1 increases the amount of USP29.
| 1
FUBP1 increases the amount of USP29. 1 / 1
| 1
reach
"JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress."
21285945
FUBP1 activates USP29.
| 1
FUBP1 activates USP29. 1 / 1
| 1
reach
"USP29 is induced by JTV1 and FBP driven transcription in response to oxidative stress, and was also shown to be important for the full activation of PUMA and apoptosis [XREF_BIBR]."
24143256
E7 affects USP33
| 2
USP29 binds USP33 and E7. 2 / 2
| 2
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
CDC25A affects USP29
| 2
CDC25A binds USP29. 2 / 2
| 2
sparser
"To further investigate the physical association of Cdc25A and USP29, HEK293 cells were co-transfected with Myc-Cdc25A and GFP-USP29 and subjected to immunoprecipitation with anti-Myc or -GFP antibodies, followed by Western blotting with reciprocal antibodies."
34071237
sparser
"Thus, our data indicated that Cdc25A and USP29 bound to each other and were co-localized."
34071237
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP29.
1 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
21354282
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP29.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
21296121
Valproic acid affects USP29
1 |
Valproic acid methylates USP29. 1 / 1
1 |
ctd
No evidence text available
29154799
Transfection dsDNA Poly affects USP29
| 1
Transfection dsDNA Poly activates USP29. 1 / 1
| 1
eidos
"Interestingly , SeV infection , transfection of dsDNA or Poly ( I :C ) or treatment of type I IFNs did not induce upregulation of USP29 ."
32457395
Thimerosal affects USP29
1 |
Thimerosal decreases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
24675092
Promoter affects USP29
| 1
Promoter decreases the amount of USP29. 1 / 1
| 1
reach
"Deletion of the U1 promoter results in a loss of allele-specific methylation of Peg3-DMR, causing the biallelic expression or double dosage of Peg3 and Usp29 [15]."
34048454
Polyubiquitin affects USP29
| 1
USP29 binds polyubiquitin. 1 / 1
| 1
sparser
"USP29 constitutively interacts with cGAS and deconjugates K48-linked polyubiquitin chains from cGAS in the absence or presence of HSV-1 infection, which stabilizes cGAS and promotes cGAS-mediated cellular antiviral responses."
32457395
Oncoprotein affects USP29
| 1
USP29 binds HR and oncoprotein. 1 / 1
| 1
sparser
"The USP29, a DUB implicated in thiol-dependent hydrolysis, also interacts with HR HPV-16, -18 and -33 E7 oncoproteins [ xref ]."
32085533
Nuclear factor-like 2 affects USP29
| 1
USP29 binds nuclear factor-like 2. 1 / 1
| 1
reach
"We then showed that USP29 interacts with, deubiquitinates, and therefore, stabilizes nuclear factor-like 2 (NRF2), thereby regulating microglia/macrophages polarization."
34562326
Methylmercury chloride decreases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
23103053
Metastatic-inducing affects USP29
| 1
Metastatic-inducing activates USP29. 1 / 1
| 1
eidos
"USP29 can be induced by major EMT and metastatic-inducing factors such as TGFbeta , TNFalpha , and hypoxia ."
| PMC
Hsa-miR-335-5p affects USP29
1 |
Hsa-miR-335-5p decreases the amount of USP29. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Element binding protein affects USP29
| 1
Element binding protein activates USP29. 1 / 1
| 1
sparser
"Ubiquitin-specific peptidase 29 (USP29) deconjugates ubiquitin from p53 and stabilizes p53. xref USP29 is activated by the far upstream element binding protein (FBP) and reverses MDM2-directed p53 ubiquitination to protect p53 from degradation."
32532965
Cadmium dichloride increases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
20061341
CGAS affects TRIM38
| 1
TRIM38 binds USP29 and cGAS. 1 / 1
| 1
sparser
"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38-mediated sumoylation and USP29-mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
Bisphenol F affects USP29
1 |
Bisphenol F increases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
30951980
Bisphenol A affects USP29
1 |
Bisphenol A decreases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
25181051
Benzo[a]pyrene affects USP29
1 |
Benzo[a]pyrene increases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
22316170
USP29 affects ubiquitination cGAS K464R cGAS
| 1
USP29 inhibits ubiquitination cGAS K464R cGAS. 1 / 1
| 1
eidos
"In this context , we noted that USP29 inhibited ubiquitination of cGAS ( K464R ) but not cGAS ( K271R ) after HSV-1 infection , and that knockout of USP29 potentiated ubiquitination of cGAS ( K464R ) but not cGAS ( K271R ) before or after HSV-1 infection ."
32457395
USP29 affects type I IFNs
| 1
USP29 activates type I IFNs. 1 / 1
| 1
reach
"Consistently, Usp29 m/m mice produce decreased type I IFNs and proinflammatory cytokines after HSV-1 infection and are hypersensitive to HSV-1 infection compared to the wild-type littermates."
32457395
USP29 affects tumorigenesis in vitro
| 1
USP29 activates tumorigenesis in vitro. 1 / 1
| 1
eidos
"Altogether , our results show that USP29 is highly upregulated in colon cancers and promotes tumorigenesis in vitro and in vivo ."
34072621
USP29 affects tumor mouse xenograft models
| 1
USP29 activates tumor mouse xenograft models. 1 / 1
| 1
eidos
"Furthermore , our data suggests that USP29 knockdown reduced the tumor volume of mouse xenograft models ."
34072621
USP29 affects sub-G1 population
| 1
USP29 inhibits sub-G1 population. 1 / 1
| 1
eidos
"Consistent with those results , loss of USP29 elevated the sub-G1 population and cleaved caspase-3 expression ( Figure 4 ) ."
34072621
USP29 affects sensitivity cells
| 1
USP29 inhibits sensitivity cells. 1 / 1
| 1
eidos
"The absence of USP29 , and thus of HIF1alpha transcriptional activity , reduces the levels of aerobic glycolysis and restores sensitivity to Sorafenib in Sorafenib-resistant HCC cells in vitro and in xenograft transplantation mouse models in vivo ."
34272356
reach
"USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress."
32968046
USP29 affects resistance cells
| 1
USP29 activates resistance cells. 1 / 1
| 1
eidos
"Together , the data demonstrate that , as a DUB of HIF1alpha , USP29 promotes Sorafenib resistance in HCC cells , in parts by upregulating glycolysis , thereby opening new avenues for therapeutically targeting Sorafenib-resistant HCC in patients ."
34272356
USP29 inhibits proteasome complex disassembly. 1 / 1
| 1
reach
"The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b."
35638730
USP29 affects proteasomal cGAS
| 1
USP29 inhibits proteasomal cGAS. 1 / 1
| 1
eidos
"These data together suggest that USP29 deconjugates K48-linked polyubiquitin chains from cGAS and thereby inhibits the proteasomal degradation of cGAS ."
32457395
USP29 affects proliferative behavior colon cancer cells
| 1
USP29 activates proliferative behavior colon cancer cells. 1 / 1
| 1
eidos
"Generation of USP29-Depleted Cells Using CRISPR-Cas9 System Given that USP29 promotes the proliferative behavior of colon cancer cells , we examined its role in the canonical DNA damage and cell-cycle progression of HCT116 cells by generating USP29 knockout using the CRISPR-Cas9 system ."
34072621
USP29 affects polyubiquitination protein
| 1
USP29 inhibits polyubiquitination protein. 1 / 1
| 1
eidos
"Subsequent sub-screening identified 23 DUBs that interact with SNAI1 , out of which USP29 , USP36 , and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein ."
| PMC
USP29 affects polyubiquitination Cdc25A
| 1
USP29 inhibits polyubiquitination Cdc25A. 1 / 1
| 1
eidos
"The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life ."
34071237
USP29 affects polyubiquitin
| 1
USP29 binds polyubiquitin. 1 / 1
| 1
sparser
"USP29 constitutively interacts with cGAS and deconjugates K48-linked polyubiquitin chains from cGAS in the absence or presence of HSV-1 infection, which stabilizes cGAS and promotes cGAS-mediated cellular antiviral responses."
32457395
USP29 affects pathogenesis
| 1
USP29 activates pathogenesis. 1 / 1
| 1
reach
"The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b."
35638730
USP29 affects oncoprotein
| 1
USP29 binds HR and oncoprotein. 1 / 1
| 1
sparser
"The USP29, a DUB implicated in thiol-dependent hydrolysis, also interacts with HR HPV-16, -18 and -33 E7 oncoproteins [ xref ]."
32085533
USP29 affects oncogenic transformation
| 1
USP29 activates oncogenic transformation. 1 / 1
| 1
eidos
"Altogether , our results implied that USP29 promoted cell cycle progression and oncogenic transformation by regulating protein turnover of Cdc25A ."
34071237
USP29 affects nuclear factor-like 2
| 1
USP29 binds nuclear factor-like 2. 1 / 1
| 1
reach
"We then showed that USP29 interacts with, deubiquitinates, and therefore, stabilizes nuclear factor-like 2 (NRF2), thereby regulating microglia/macrophages polarization."
34562326
USP29 affects migration
| 1
USP29 activates migration. 1 / 1
| 1
eidos
"We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation , migration , and invasion of cancer cells in vitro ."
34071237
USP29 affects malonaldehyde
| 1
USP29 activates malonaldehyde. 1 / 1
| 1
reach
"And USP29 overexpression also significantly promoted MDA generation in I/R mice (Figure 3(h))."
34824671
USP29 affects lactate
| 1
USP29 activates lactate. 1 / 1
| 1
reach
"Depletion of USP29 significantly reduces glycolysis and lactate production."
34272356
USP29 affects invasion cancer cells
| 1
USP29 activates invasion cancer cells. 1 / 1
| 1
eidos
"We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation , migration , and invasion of cancer cells in vitro ."
34071237
USP29 affects interaction Snail SCP1
| 1
USP29 activates interaction Snail SCP1. 1 / 1
| 1
eidos
"Mechanistically , USP29 enhances the interaction of Snail and SCP1 , resulting in simultaneous dephosphorylation and deubiquitination of Snail and thereafter cooperative prevention of Snail degradation ."
32973332
USP29 affects innate antiviral responses
| 1
USP29 activates innate antiviral responses. 1 / 1
| 1
eidos
"In addition , USP29 also interacted with cyclic GMP-AMP synthase and promoted innate antiviral responses against DNA viruses and autoimmunity [ 24 ] ."
34824671
USP29 affects focus 53BP1
| 1
USP29 activates focus 53BP1. 1 / 1
| 1
eidos
"Importantly , USP29 knockdown inhibits the irradiation-induced increase in H4K20 monomethylation , thereby preventing focus formation of 53BP1 in response to DNA damage ."
36010569
USP29 affects downstream targets
| 1
USP29 activates downstream targets. 1 / 1
| 1
eidos
"In view of the fact that USP29 is a deubiquitinase and modulates the downstream targets via catalyzing the removal of monoubiquitin or polyubiquitin chains at the posttranscriptional level , therefore , we speculated that SIRT1 expression was not directly modulated by USP29 ."
34824671
USP29 affects cleaved caspase-3
| 1
USP29 inhibits cleaved caspase-3. 1 / 1
| 1
eidos
"We found that USP29 depletion increased the expression of cleaved caspase-3 compared with the scrambled sgRNA control ( p = 0.0007 ) ( Figure 4E ) , and USP29 reconstitution decreased the expression of cleaved caspase-3 compared with the USP29-depleted cells ( p = 0.0025 ) ."
34072621
USP29 affects chemotherapy-induced stemness
| 1
USP29 activates chemotherapy-induced stemness. 1 / 1
| 1
eidos
"USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress ."
32968046
USP29 affects cerebral R-induced caspase-3 activation
| 1
USP29 activates cerebral R-induced caspase-3 activation. 1 / 1
| 1
eidos
"And USP29 inhibition also suppressed cerebral I / R-induced caspase-3 activation ( Figure 2 ( l ) ) ."
34824671
USP29 affects cerebral R-induced SIRT1
| 1
USP29 activates cerebral R-induced SIRT1. 1 / 1
| 1
eidos
"As shown in Figures 4 ( a ) -4 ( d ) , USP29 inhibition did not affect cerebral SIRT3 expression upon I / R injury but restored cerebral I / R-induced downregulation of SIRT1 , while USP29 overexpression further decreased SIRT1 expression in I / R-injured brains ."
34824671
USP29 affects cerebral R-caused brain edema
| 1
USP29 activates cerebral R-caused brain edema. 1 / 1
| 1
eidos
"In addition , USP29 inhibition significantly attenuated cerebral I / R-caused brain edema , as evidenced by the decreased brain water content ( Figure 1 ( i ) ) ."
34824671
USP29 affects cerebral R injury mice
| 1
USP29 activates cerebral R injury mice. 1 / 1
| 1
eidos
"The findings enable us to believe that USP29 inhibition prevents cerebral I / R injury in mice ."
34824671
USP29 affects cellular sensitivity irradiation
| 1
USP29 inhibits cellular sensitivity irradiation. 1 / 1
| 1
eidos
"Lastly , depletion of USP29 increases the cellular sensitivity to irradiation ."
36010569
USP29 affects cell cycle
| 1
USP29 activates cell cycle. 1 / 1
| 1
eidos
"Altogether , our results implied that USP29 promoted cell cycle progression and oncogenic transformation by regulating protein turnover of Cdc25A ."
34071237
USP29 affects cell apoptosis
| 1
USP29 activates cell apoptosis. 1 / 1
| 1
eidos
"Liu et al. reported that USP29 expression was elevated upon oxidative stress and then promoted cell apoptosis via directly deubiquitinating p53 [ 25 ] ."
34824671
USP29 affects cancer stem cell-like characteristics lung adenocarcinoma cells
| 1
USP29 activates cancer stem cell-like characteristics lung adenocarcinoma cells. 1 / 1
| 1
eidos
"USP29 upregulation enhances the cancer stem cell-like characteristics in lung adenocarcinoma cells to promote tumorigenesis in athymic nude mice ."
32968046
USP29 affects benefits
| 1
USP29 activates benefits. 1 / 1
| 1
eidos
"Proteomics analysis revealed that ubiquitin-specific protease 29 ( USP29 ) was markedly increased in MEVs , and knockdown of USP29 in MEVs ( shUSP29-MEVs ) abolished MEVs-mediated benefits in vitro and in vivo ."
34562326
USP29 affects autoimmunity Cyclic GMP-AMP synthase
| 1
USP29 activates autoimmunity Cyclic GMP-AMP synthase. 1 / 1
| 1
eidos
"USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity Cyclic GMP-AMP synthase ( cGAS ) is an essential sensor of cytosolic DNA and critically mediates innate immune responses and autoimmunity ."
32457395
USP29 affects autoimmunity Correction
| 1
USP29 activates autoimmunity Correction. 1 / 1
| 1
eidos
"Author Correction : USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity Correction to : Cell Research 10.1038 / s41422-020-0341-6 , published online 26 May 2020 We just found several mistakes and typos in the paper published on May 26 , 2020 ."
32632253
USP29 affects apoptosis HCT116 cells
| 1
USP29 inhibits apoptosis HCT116 cells. 1 / 1
| 1
eidos
"We also demonstrated that USP29 depletion hampers the colony formation and increases apoptosis of HCT116 cells ."
34072621
USP29 affects aerobic glycolysis
| 1
USP29 activates aerobic glycolysis. 1 / 1
| 1
eidos
"The absence of USP29 , and thus of HIF1alpha transcriptional activity , reduces the levels of aerobic glycolysis and restores sensitivity to Sorafenib in Sorafenib-resistant HCC cells in vitro and in xenograft transplantation mouse models in vivo ."
34272356
USP29 affects Zim1
| 1
USP29 increases the amount of Zim1. 1 / 1
| 1
reach
"For the genes at the Peg3 imprinted region, decreased expression of Zim1 and increased expression of Usp29, Peg3, and Peg3os were similarly observed comparing female M−Z− embryos with female M+Z+ embryos or comparing male M−Z− embryos with male M+Z+ embryos (Table 2, Supplementary Figure S10A-S10A')."
35252168
USP29 affects USP29
| 1
USP29 activates USP29. 1 / 1
| 1
eidos
"Collectively , these data indicate that Snail is a crucial substrate for USP29 to promote cell migration and USP29 / SCP1 complex may be new therapeutic targets to treat metastatic cancer ."
32973332
USP29 affects Thymoma
| 1
USP29 activates Thymoma. 1 / 1
| 1
reach
"In MG-related thymomas, the mRNA and protein levels of deubiquitylases USP29 were substantially elevated."
36628242
USP29 affects TWIST1
| 1
USP29 leads to the deubiquitination of TWIST1. 1 / 1
| 1
reach
"The deubiquitination of TWIST1 catalyzed by USP29 is required for its stabilization and subsequent EMT and CSC functions in TNBC, thereby conferring chemotherapeutic resistance and metastasis."
36782089
USP29 affects THP-1 Cells
| 1
USP29 activates THP-1 Cells. 1 / 1
| 1
eidos
"39 , 42 USP29 promotes HSV-1-triggered innate antiviral signaling in THP-1 cells Because USP29 interacted with cGAS and was upregulated by HSV-1 infection , we investigated its role in regulating HSV-1-or cytoplasmic DNA-triggered innate immune signaling ."
32457395
USP29 affects SYCP1
| 1
SYCP1 binds USP29. 1 / 1
| 1
reach
"Collectively, these data indicate that Snail is a crucial substrate for USP29 to promote cell migration and USP29 and SCP1 complex may be new therapeutic targets to treat metastatic cancer."
32973332
USP29 affects SOD2
| 1
USP29 decreases the amount of SOD2. 1 / 1
| 1
reach
"Accordingly, USP29 knockout also restored the expressions of downstream HO-1 and SOD2 (Figure 2(g))."
34824671
USP29 affects SETD8 protein
| 1
USP29 activates SETD8 protein. 1 / 1
| 1
eidos
"Depletion of USP29 leads to decreased SETD8 protein levels , an effect that is independent of the cell cycle ."
36010569
USP29 affects SARS-CoV-2
| 1
USP29 activates SARS-CoV-2. 1 / 1
| 1
reach
"The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b."
35638730
USP29 affects ROR
| 1
USP29 increases the amount of ROR. 1 / 1
| 1
reach
"This work exhibited that the elevated USP29 enhanced RORγt expression, which in turn affected the Th17 cell growth in thymomatous MG."
36628242
USP29 affects OGD R-induced caspase-3
| 1
USP29 activates OGD R-induced caspase-3. 1 / 1
| 1
eidos
"We also found that USP29 knockdown significantly suppressed OGD / R-induced increases of caspase-3 activity ( Figure S1C ) ."
34824671
USP29 affects NF-kappaB activation
| 1
USP29 inhibits NF-kappaB activation. 1 / 1
| 1
eidos
"USP29 interacts with the carboxyl end of ORF9b and removes ubiquitin chains from the protein , thereby inhibiting type I interferon ( IFN ) induction and NF-kappaB activation ."
35638730
USP29 affects Ki67 colon cancer cells
| 1
USP29 activates Ki67 colon cancer cells. 1 / 1
| 1
eidos
"Our results showed that USP29 and Ki67 are not binding each other ( Figure S1 ) , suggesting that the expression of USP29 increases Ki67 expression in colon cancer cells without interacting with Ki67 ."
34072621
USP29 affects K48-linked ubiquitination degradation cGAS
| 1
USP29 inhibits K48-linked ubiquitination degradation cGAS. 1 / 1
| 1
eidos
"Consistent with the notion that USP29 deficiency promoted K48-linked ubiquitination and degradation of cGAS , we found that treatment of MG132 but not 3MA fully prevented the degradation of cGAS in Usp29m / m MEFs in the presence or absence of HSV-1 infection ( Fig. 6g ) ."
32457395
USP29 affects Interferon
| 1
USP29 inhibits Interferon. 1 / 1
| 1
eidos
"USP29 interacts with the carboxyl end of ORF9b and removes ubiquitin chains from the protein , thereby inhibiting type I interferon ( IFN ) induction and NF-kappaB activation ."
35638730
USP29 affects IFNA
| 1
USP29 activates IFNA. 1 / 1
| 1
reach
"In addition, knockdown of USP29 significantly impaired the production of IFN-beta, IFN-alpha, IL-6, and TNF after infection of HSV-1 or transfection of various DNA ligands."
32457395
USP29 affects IFN-beta IFN-alpha IL-6 TNF
| 1
USP29 activates IFN-beta IFN-alpha IL-6 TNF. 1 / 1
| 1
eidos
"In addition , knockdown of USP29 significantly impaired the production of IFN-beta , IFN-alpha , IL-6 , and TNF after infection of HSV-1 or transfection of various DNA ligands ( Fig. 2e ) ."
32457395
USP29 affects HSV-1-triggered downstream
| 1
USP29 activates HSV-1-triggered downstream. 1 / 1
| 1
eidos
"USP29 deficiency impairs HSV-1-triggered expression of downstream genes ."
32457395
USP29 affects HSV-1-triggered downstream investigate USP29 regulating antiviral signaling
| 1
USP29 activates HSV-1-triggered downstream investigate USP29 regulating antiviral signaling. 1 / 1
| 1
eidos
"USP29 deficiency impairs HSV-1-triggered expression of downstream genes To further investigate the role of USP29 in regulating antiviral signaling in vivo , we generated USP29-deficient mice by CRISPR / Cas9-mediated genome editing ( Supplementary information , Fig. S3a ) ."
32457395
USP29 affects HR
| 1
USP29 binds HR and oncoprotein. 1 / 1
| 1
sparser
"The USP29, a DUB implicated in thiol-dependent hydrolysis, also interacts with HR HPV-16, -18 and -33 E7 oncoproteins [ xref ]."
32085533
USP29 affects HMOX1
| 1
USP29 decreases the amount of HMOX1. 1 / 1
| 1
reach
"Accordingly, USP29 knockout also restored the expressions of downstream HO-1 and SOD2 (Figure 2(g))."
34824671
USP29 affects HCT116
| 1
USP29 binds MKI67 and HCT116. 1 / 1
| 1
sparser
"We next checked the interactions between endogenous USP29 and Ki67 in HCT116 cells."
34072621
USP29 affects H4K20 monomethylation
| 1
USP29 activates H4K20 monomethylation. 1 / 1
| 1
eidos
"Importantly , USP29 knockdown inhibits the irradiation-induced increase in H4K20 monomethylation , thereby preventing focus formation of 53BP1 in response to DNA damage ."
36010569
USP29 affects H2AX
| 1
USP29 increases the amount of H2AX. 1 / 1
| 1
sparser
"It is noteworthy that sgRNA1 targeting USP29 induced more γH2AX protein expression than either sgRNA2 or the scrambled sgRNA control ( xref A, lane 2)."
34072621
USP29 affects H2AC20
1 |
USP29 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"Both USP44 and USP29 promoted efficient deubiquitylation of histone H2A"
23615962
USP29 affects FUBP1
| 1
USP29 increases the amount of FUBP1. 1 / 1
| 1
reach
"JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress."
21285945
USP29 affects ELANE
| 1
USP29 activates ELANE. 1 / 1
| 1
reach
"Fig. 3d), supporting a role of USP29 in stabilizing HIF1α in HCC and HEK cells.We further determined the robustness of USP29-mediated stabilization of HIF1α in a hypoxia-reoxygenation assay in Sorafenib-resistant HLE cells."
34272356
USP29 affects Disease
| 1
USP29 activates Disease. 1 / 1
| 1
eidos
"Recently , USP29 was found to be abundantly expressed in the brain and contributed to the progression of Parkinson 's disease [ 26 ] ."
34824671
USP29 affects DNA Delays Cell-Cycle Progression investigate
| 1
USP29 activates DNA Delays Cell-Cycle Progression investigate. 1 / 1
| 1
eidos
"USP29 Depletion Induces DNA Damage and Delays Cell-Cycle Progression To investigate whether the loss of USP29 function in HCT116 causes DNA damage , we checked the expression of a canonical DNA double strand break marker , gammaH2AX ."
34072621
USP29 affects Colon Cancer Growth
| 1
USP29 activates Colon Cancer Growth. 1 / 1
| 1
eidos
"Loss of USP29 Expression Inhibits Colon Cancer Growth In Vitro and In Vivo Because USP29 facilitates colon cancer proliferation , we wondered whether USP29-depleted HCT116 cells might inhibit colon cancer growth in vitro and in vivo ."
34072621
USP29 affects Cerebral R Injury
| 1
USP29 activates Cerebral R Injury. 1 / 1
| 1
eidos
"USP29 Inhibition Prevents Cerebral I / R Injury in Mice We first examined the expression of USP29 in the primary cortical neurons upon OGD / R stimulation and found that the protein and mRNA of USP29 were increased in OGD / R-challenged cells ( Figures 1 ( a ) and 1 ( b ) ) ."
34824671
USP29 affects Cerebral Oxidative Stress Apoptosis free radicals contribute cerebral R injury neuronal apoptosis
| 1
USP29 activates Cerebral Oxidative Stress Apoptosis free radicals contribute cerebral R injury neuronal apoptosis. 1 / 1
| 1
eidos
"USP29 Inhibition Diminishes Cerebral I / R-Induced Oxidative Stress and Apoptosis Excessive free radicals contribute to the progression of cerebral I / R injury and neuronal apoptosis ; therefore , we next measured the role of USP29 inhibition on oxidative stress ."
34824671
USP29 affects Cell Previous researchers reported functions USP29 regulate cancer-related proteins
| 1
USP29 activates Cell Previous researchers reported functions USP29 regulate cancer-related proteins. 1 / 1
| 1
eidos
"USP29 Is Highly Upregulated in Clinical Human Colon Cancer Tissues and Promotes Cell Proliferation Previous researchers reported the functions of USP29 and its ability to regulate cancer-related proteins [ 12,13,14 ] ."
34072621
USP29 affects Cdc25A-mediated cell
| 1
USP29 activates Cdc25A-mediated cell. 1 / 1
| 1
eidos
"We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation , migration , and invasion of cancer cells in vitro ."
34071237
reach
"USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress."
32968046
USP29 affects CTSB
1 |
USP29 binds CTSB. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP29 affects CHEK1
| 1
USP29 phosphorylates CHEK1. 1 / 1
| 1
reach
"Most importantly, USP29 knockdown results in an impaired phosphorylation of Chk1 after DNA damage and USP29 depleted cells show a major defect in the S-phase progression."
24632611
USP29 affects CDK1
| 1
CDK1 binds USP29. 1 / 1
| 1
sparser
"Taken together, the findings reveal a previously unrecognized tumor-promoting function and clinical significance of the CDK1-USP29 axis through stabilizing TWIST1 and provide the preclinical evidence that targeting this axis is an appealing therapeutic strategy to conquer chemo-resistance and metastasis in TNBC."
36782089
USP29 affects CASP14
| 1
USP29 activates CASP14. 1 / 1
| 1
reach
"USP29 Inhibition Prevents Cerebral I/R Injury in Mice."
34824671
USP29 affects Brain Edema
| 1
USP29 activates Brain Edema. 1 / 1
| 1
reach
"In addition, USP29 inhibition significantly attenuated cerebral I/R-caused brain edema, as evidenced by the decreased brain water content (Figure 1(i))."
34824671
USP29 affects ARNT
| 1
USP29 leads to the deacetylation of ARNT. 1 / 1
| 1
reach
"Mechanistically, neuronal USP29 enhanced p53/miR-34a-mediated silent information regulator 1 downregulation and then promoted the acetylation and suppression of brain and muscle ARNT-like protein, thereby aggravating oxidative stress and apoptosis upon cerebral I/R injury."
34824671
TRIM38 affects cGAS
| 1
TRIM38 binds USP29 and cGAS. 1 / 1
| 1
sparser
"In addition, we found that TRIM38 and USP29 interacts with cGAS independently, suggesting that TRIM38-mediated sumoylation and USP29-mediated deubiquitination of cGAS cooperatively regulate the stability of cGAS."
32457395
TNF affects USP29
| 1
TNF inhibits USP29. 1 / 1
| 1
reach
"Interestingly, the levels of cGAS and the expression of Tnf, Il6, Il12p40 and Ifit3 were significantly decreased in Trex1 -/- Usp29 m/m BMDCs compared to Trex1 -/- BMDCs (Supplementary information, Fig.S7d)."
32457395
Suppl affects USP29
| 1
Suppl inhibits USP29. 1 / 1
| 1
reach
"First, analysis of HLE cells by immunofluorescence microscopy revealed an increase in nuclear localization of HIF1α upon expression of Myc-tagged USP29 (Fig. 2e) and a reduction of nuclear HIF1α upon siRNA-mediated depletion of USP29 (Fig. 2f; Suppl."
34272356
SeV infection affects USP29
| 1
SeV infection activates USP29. 1 / 1
| 1
eidos
"Interestingly , SeV infection , transfection of dsDNA or Poly ( I :C ) or treatment of type I IFNs did not induce upregulation of USP29 ."
32457395
SYCP1 affects USP29
| 1
SYCP1 binds USP29. 1 / 1
| 1
reach
"Collectively, these data indicate that Snail is a crucial substrate for USP29 to promote cell migration and USP29 and SCP1 complex may be new therapeutic targets to treat metastatic cancer."
32973332
SOX8 affects USP29
| 1
SOX8 inhibits USP29. 1 / 1
| 1
reach
"Moreover, overexpression of KIAA1429 or SOX8 reversed the inhibitory effects of USP29 depletion on CRC cell proliferation."
36373629
SIRT1 silence affects USP29
| 1
SIRT1 silence inhibits USP29. 1 / 1
| 1
eidos
"Accordingly , SIRT1 silence blocked USP29 inhibition-mediated inhibition on caspase-3 activity in OGD / R-stimulated neurons ( Figure S2C ) ."
34824671
Poly affects USP29
| 1
Poly activates USP29. 1 / 1
| 1
eidos
"or Poly ( I :C ) or treatment of type I IFNs did not induce upregulation of USP29 ."
32457395
Peg3-DMR affects USP29
| 1
Peg3-DMR activates USP29. 1 / 1
| 1
reach
"This was expected since the deletion of the Peg3-DMR in the KO2 samples abolishes the bidirectional promoter for Peg3/Usp29."
29734399
PFT-α affects USP29
| 1
PFT-α decreases the amount of USP29. 1 / 1
| 1
reach
"And the pretreatment with PFT-α or miR-34a antagomir also significantly blocked the deleterious effects of USP29 overexpression upon cerebral I/R injury, as evidenced by the decreased infarct volume, neurological deficit score, and brain edema (Figures 6(h)–6(j))."
34824671
NeoR affects USP29
| 1
NeoR decreases the amount of USP29. 1 / 1
| 1
reach
"The purpose of positioning NeoR in this manner was to block the transcription of Usp29 with the Poly-A signal that had been included as part of NeoR."
27327533
N-nitrosomorpholine increases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
19716841
MKI67 affects HCT116
| 1
USP29 binds MKI67 and HCT116. 1 / 1
| 1
sparser
"We next checked the interactions between endogenous USP29 and Ki67 in HCT116 cells."
34072621
MIMT1 allele affects USP29
| 1
MIMT1 allele activates USP29. 1 / 1
| 1
reach
"Another suggested mechanism is the loss of imprinting (LOI) of PEG3 and/or USP29 mediated by silenced expression of the paternal MIMT1 allele."
21152099
MACROH2A1 affects USP29
| 1
MACROH2A1 increases the amount of USP29. 1 / 1
| 1
reach
"It is plausible that macroH2A1 knockdown might have down-regulated the transcription of Peg3 and Usp29 through other unknown transcription factors like USF2."
18166131
Il12p40 affects USP29
| 1
Il12p40 inhibits USP29. 1 / 1
| 1
reach
"Interestingly, the levels of cGAS and the expression of Tnf, Il6, Il12p40 and Ifit3 were significantly decreased in Trex1 -/- Usp29 m/m BMDCs compared to Trex1 -/- BMDCs (Supplementary information, Fig.S7d)."
32457395
IL6 affects USP29
| 1
IL6 inhibits USP29. 1 / 1
| 1
reach
"Interestingly, the levels of cGAS and the expression of Tnf, Il6, Il12p40 and Ifit3 were significantly decreased in Trex1 -/- Usp29 m/m BMDCs compared to Trex1 -/- BMDCs (Supplementary information, Fig.S7d)."
32457395
IFIT3 affects USP29
| 1
IFIT3 inhibits USP29. 1 / 1
| 1
reach
"Interestingly, the levels of cGAS and the expression of Tnf, Il6, Il12p40 and Ifit3 were significantly decreased in Trex1 -/- Usp29 m/m BMDCs compared to Trex1 -/- BMDCs (Supplementary information, Fig.S7d)."
32457395
ICR affects USP29
| 1
ICR increases the amount of USP29. 1 / 1
| 1
reach
"Deletion of this ICR abolishes the transcription of Peg3 and Usp29, and also causes biallelic expression, or double dosage for some of the adjacent imprinted genes [18]."
29734399
HR affects oncoprotein
| 1
USP29 binds HR and oncoprotein. 1 / 1
| 1
sparser
"The USP29, a DUB implicated in thiol-dependent hydrolysis, also interacts with HR HPV-16, -18 and -33 E7 oncoproteins [ xref ]."
32085533
HNF1B affects USP29
| 1
HNF1B activates USP29. 1 / 1
| 1
reach
"However, USP29, a DUB that closely related to USP28, could not be induced by HNF-1beta."
29707125
HIF1A affects USP29
| 1
USP29 binds HIF1A. 1 / 1
| 1
reach
"USP29 interacts with and deubiquitylates HIF1alpha."
34272356
HCT116 affects USP29
| 1
USP29 binds MKI67 and HCT116. 1 / 1
| 1
sparser
"We next checked the interactions between endogenous USP29 and Ki67 in HCT116 cells."
34072621
ECR18 affects USP29
| 1
ECR18 activates USP29. 1 / 1
| 1
reach
"One ECR, ECR18, has been shown to physically interact with the promoter of Peg3/Usp29, and also recently demonstrated to be a shared enhancer between the paternally expressed Peg3/Usp29 and the maternally expressed Zim1 [17]."
31639176
CTSB affects USP29
1 |
USP29 binds CTSB. 1 / 1
1 |
biogrid
No evidence text available
19615732
4,4'-sulfonyldiphenol increases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
30951980
2,3',4,4',5-pentachlorobiphenyl increases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
31388691
2,2',4,4'-tetrabromodiphenyl ether increases the amount of USP29. 1 / 1
1 |
ctd
No evidence text available
27291303