IndraLab

Statements

USP24 is modified
64 | 20
USP24 is phosphorylated.
64 | 17
USP24 is phosphorylated on S2047. 10 / 17
16 | 1
hprd
No evidence text available
19007248
hprd
No evidence text available
18088087
hprd
No evidence text available
18767875
hprd
No evidence text available
19664994
sparser
"Here we also found that USP24 phosphorylation at Ser1616, Ser2047 and Ser2604 was increased in EGF-treated primary lung cells ( xref )."
27991932
hprd
No evidence text available
18669648
hprd
No evidence text available
20166139
hprd
No evidence text available
18707149
hprd
No evidence text available
18691976
hprd
No evidence text available
17322306
USP24 is phosphorylated. 10 / 10
| 10
sparser
"Phosphorylation of USP24 at these three residues was increased during mitosis ( xref )."
27991932
sparser
"Three mutated residues and triple mutant S3A increased the USP24 level, suggesting that USP24 phosphorylation might be the reason for the decreased USP24 expression during mitosis and tumorigenesis."
27991932
sparser
"We found that USP24 interacted with CDK1/cyclin B during the mitotic stage, and that the USP24 phosphorylation signal was higher in mitosis than in interphase ( xref ; xref )."
27991932
sparser
"In addition, we found that USP24 phosphorylation at Ser2604 was declined by U0126, which inhibited the Erk1/2 activities in A549 cells ( xref ); however, USP24 phosphorylation was not decreased by LY294002, which inhibited the PI3K activities ( xref )."
27991932
sparser
"Mutations at these residues increased the USP24 half-life during mitosis, suggesting that USP24 phosphorylation during mitosis decreased USP24 expression ( xref )."
27991932
sparser
"In addition to the phosphorylation of USP24 in mitosis, USP24 is also phosphorylated by EGF-activated Erk1/2 kinase activity to turnover USP24."
27991932
sparser
"Antibodies that recognized these phosphorylation residues were produced to study USP24 phosphorylation."
27991932
sparser
"Phosphorylation of USP24 increases its degradation during tumorigenesis and cell cycle progression."
27991932
sparser
"USP24 phosphorylation increased the recruitment of the E3 ligase cdc20, which is the subunit of the APC/C complex that provides the E3 ligase activity."
27991932
sparser
"Here we found that the phosphorylation of several USP24 residues was regulated by EGF treatment and mitotic CDK1 to enhance USP24 degradation in a polyubiquitination-dependent manner."
27991932
USP24 is phosphorylated on S2604. 7 / 7
3 | 4
hprd
No evidence text available
20068231
sparser
"Further study indicated that USP24 could interact with Erk1/2 and p-Erk1/2 ( xref ), suggesting that Erk1/2 might be the kinase for phosphorylation of USP24 at S2604 to decrease the USP24 level."
27991932
sparser
"Here we also found that USP24 phosphorylation at Ser1616, Ser2047 and Ser2604 was increased in EGF-treated primary lung cells ( xref )."
27991932
hprd
No evidence text available
18691976
hprd
No evidence text available
18669648
sparser
"In addition, we found that USP24 phosphorylation at Ser2604 was declined by U0126, which inhibited the Erk1/2 activities in A549 cells ( xref ); however, USP24 phosphorylation was not decreased by LY294002, which inhibited the PI3K activities ( xref )."
27991932
sparser
"Conversely, USP24 phosphorylation at Ser1616 and Ser2604 was decreased in FTI-276-treated A549 cells ( xref )."
27991932
USP24 is phosphorylated on S2561. 5 / 5
5 |
hprd
No evidence text available
17322306
hprd
No evidence text available
19651622
hprd
No evidence text available
20068231
hprd
No evidence text available
20058876
hprd
No evidence text available
18669648
USP24 is phosphorylated on S251. 5 / 5
5 |
hprd
No evidence text available
19651622
hprd
No evidence text available
20058876
hprd
No evidence text available
17322306
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
USP24 is phosphorylated on S1616. 4 / 4
2 | 2
hprd
No evidence text available
17081983
hprd
No evidence text available
20068231
sparser
"Here we also found that USP24 phosphorylation at Ser1616, Ser2047 and Ser2604 was increased in EGF-treated primary lung cells ( xref )."
27991932
sparser
"Conversely, USP24 phosphorylation at Ser1616 and Ser2604 was decreased in FTI-276-treated A549 cells ( xref )."
27991932
USP24 is phosphorylated on T2565. 4 / 4
4 |
hprd
No evidence text available
20068231
hprd
No evidence text available
20058876
hprd
No evidence text available
19651622
hprd
No evidence text available
18669648
USP24 is phosphorylated on T2559. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18691976
hprd
No evidence text available
19651622
USP24 is phosphorylated on S1943. 2 / 2
2 |
hprd
No evidence text available
19651622
hprd
No evidence text available
20068231
USP24 is phosphorylated on S2080. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP24 is phosphorylated on S1610. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP24 is phosphorylated on S1143. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP24 is phosphorylated on S1141. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP24 is phosphorylated on T2570. 2 / 2
2 |
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
USP24 is phosphorylated on S1612. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP24 is phosphorylated on S2077. 2 / 2
2 |
hprd
No evidence text available
18691976
hprd
No evidence text available
20068231
USP24 is phosphorylated on S1620. 1 / 1
1 |
hprd
No evidence text available
17525332
USP24 is phosphorylated on T198. 1 / 1
1 |
hprd
No evidence text available
20068231
USP24 is phosphorylated on Y205. 1 / 1
1 |
hprd
No evidence text available
20068231
USP24 is phosphorylated on S2081. 1 / 1
1 |
hprd
No evidence text available
18669648
USP24 is phosphorylated on S2587. 1 / 1
1 |
hprd
No evidence text available
20068231
USP24 is phosphorylated on S1043. 1 / 1
1 |
hprd
No evidence text available
18669648
USP24 is phosphorylated on S2613. 1 / 1
1 |
hprd
No evidence text available
20068231
USP24 is phosphorylated on S63. 1 / 1
1 |
hprd
No evidence text available
18669648
USP24 is phosphorylated on S2043. 1 / 1
1 |
hprd
No evidence text available
20068231
USP24 is phosphorylated on S58. 1 / 1
1 |
hprd
No evidence text available
18669648
USP24 is ubiquitinated.
| 3
USP24 is ubiquitinated. 3 / 3
| 3
sparser
"Moreover, the USP24 ubiquitination signal was increased during the mitotic stage ( xref ; xref ), implying that the decrease in the USP24 level during mitosis might be due to the enhancement of USP24 degradation."
27991932
sparser
"In addition, there was an inverse correlation between the USP24 level and the cdc20 level (an E3 ligase in the APC/C complex), but not cdh1 level, implying that APC/C cdc20 might provide the enzymatic activity for USP24 ubiquitination ( xref ; xref )."
27991932
sparser
"Ubiquitination of USP7 (K869), USP24 (K421, K656) and USP36 (K338) were down-regulated."
33865438
USP24 affects DDB2
2 4 1 | 19 14
USP24 binds DDB2.
4 | 10 14
USP24 binds DDB2. 10 / 31
4 | 10 14
reach
"DDB2 interacts with USP24."
23159851
biogrid
No evidence text available
23159851
sparser
"These observations suggest that USP24 interacts with DDB2 in vivo, as suggested by our yeast two-hybrid screen."
23159851
reach
"Interaction between DDB2 and USP24 was confirmed by co-precipitation."
23159851
reach
"We demonstrated biochemically that USP24 binds to DDB2 and regulates DDB2 stability in human cells."
23159851
biogrid
No evidence text available
23159851
biogrid
No evidence text available
23159851
reach
"Interaction between DDB2 and USP24 was confirmed by co-precipitation."
| PMC
reach
"The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability."
23159851
sparser
"The interaction between USP24 and DDB2 was confirmed by co-immunoprecipitation."
27696486
USP24 activates DDB2.
1 | 4
USP24 activates DDB2. 3 / 4
1 | 2
reach
"USP24 targeting DDB2 and p53."
27316462
reach
"Knockdown of USP24 resulted in a decreased level of DDB2, suggesting that USP24 stabilizes DDB2 by removing the ubiquitin moiety from modified DDB2, thereby preventing DDB2 degradation."
27316462
signor
"Usp24-mediated ddb2 deubiquitination prevents ddb2 degradation"
23159851
USP24 activates ubiquitinated DDB2. 2 / 2
| 2
reach
"To examine if USP24 can target ubiquitinated DDB2 in vitro, we treated HeLa cells expressing Hig tagged DDB2 with MG132, a proteosome inhibitor, XREF_BIBR for 1 h and exposed HeLa cells to UVC (10 J/m 2) to stimulate DDB2 uniquitination for another hour, Ni-NTA beads were then used to pulldown modified His DDB2."
23159851
reach
"Our group previously reported that ubiquitinated DDB2 can be targeted by USP24, and in this study, we demonstrate that USP24 is a p53 deubiquitinase, required for p53 stabilization in unstressed cells, as well as for p53 stabilization and PUMA activation after DNA damage."
25578727
USP24 increases the amount of DDB2.
| 3
USP24 increases the amount of DDB2. 3 / 3
| 3
reach
"Importantly, knockdown of USP24 in two human cell lines decreased the steady-state levels of DDB2, indicating that USP24 mediated DDB2 deubiquitination prevents DDB2 degradation."
23159851
reach
"Importantly, knockdown of USP24 in two human cell lines decreased the steady-state levels of DDB2, indicating that USP24 mediated DDB2 deubiquitination prevents DDB2 degradation."
| PMC
reach
"As indicated in XREF_FIG, knockdown of USP24 decreased the steady-state levels of DDB2 in both HeLa and 293T cells."
23159851
USP24 deubiquitinates DDB2.
1 1 | 1
USP24 deubiquitinates DDB2. 3 / 3
1 1 | 1
ubibrowser
"USP24 targeting DDB2 and p53"
27316462
reach
"DDB2 is deubiquitinated by USP24, stabilizing the entire UV-DDB-CUL4 E3 ligase from proteasomal degradation [XREF_BIBR]."
30831436
signor
"Usp24-mediated ddb2 deubiquitination prevents ddb2 degradation"
23159851
USP24 decreases the amount of DDB2.
| 1
USP24 decreases the amount of DDB2. 1 / 1
| 1
reach
"Knockdown of USP24 decreases steady-state level of DDB2."
27696486
DDB2 affects USP24
4 | 11 14
DDB2 binds USP24.
4 | 10 14
USP24 binds DDB2. 10 / 31
4 | 10 14
reach
"DDB2 interacts with USP24."
23159851
biogrid
No evidence text available
23159851
sparser
"These observations suggest that USP24 interacts with DDB2 in vivo, as suggested by our yeast two-hybrid screen."
23159851
reach
"Interaction between DDB2 and USP24 was confirmed by co-precipitation."
23159851
reach
"We demonstrated biochemically that USP24 binds to DDB2 and regulates DDB2 stability in human cells."
23159851
biogrid
No evidence text available
23159851
biogrid
No evidence text available
23159851
reach
"Interaction between DDB2 and USP24 was confirmed by co-precipitation."
| PMC
reach
"The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability."
23159851
sparser
"The interaction between USP24 and DDB2 was confirmed by co-immunoprecipitation."
27696486
DDB2 activates USP24.
| 1
DDB2 activates USP24. 1 / 1
| 1
reach
"To investigate whether DDB2 is a direct target of USP24, we set out to evaluate interactions in vivo by co-immunoprecipitation."
23159851
USP24 affects TP53
1 1 | 1 17 3
USP24 deubiquitinates TP53.
1 | 6
USP24 deubiquitinates TP53. 7 / 7
1 | 6
reach
"These findings show that USP24 can deubiquitinate p53 in vitro."
25578727
reach
"They found also that USP24 deubiquitylates p53, activating the PUMA pathway, a regulator of DNA-damage-induced apoptosis."
27516771
reach
"Under both normal and stressed conditions p53 is also deubiquitinated by USP24 and thus stabilizing its level."
29479529
ubibrowser
"Review"
28801249
reach
"USP24 deubiquitinates p53 in vivo and in vitro."
25578727
reach
"Our data show that USP24 deubiquitinates p53 in vivo and in vitro, leading to p53 stabilization and activation."
25578727
reach
"In this study, we demonstrate that USP24 deubiquitinates p53 in human cells."
25578727
USP24 inhibits TP53.
| 1 3
USP24 inhibits TP53. 4 / 5
| 1 3
reach
"However, some groups also demonstrated that USP24 prevents P53 from degradation to regulate the DNA damage response 23."
34326684
reach
"Knockdown of USP24 failed to prevent stabilization of p53 following etoposide treatment of H4 cells), suggesting that in this cell type USP24 may be dispensable for DNA damage responses or that the very low residual USP24 protein may be sufficient."
30957634
eidos
"However , some groups also demonstrated that USP24 prevents P53 from degradation to regulate the DNA damage response 23 ."
34326684
reach
"Depletion of USP24 significantly attenuates p53 dependent apoptosis induced by DNA damage."
25578727
USP24 binds TP53.
1 | 1 3
TP53 binds USP24. 3 / 3
1 | 1 1
biogrid
No evidence text available
25578727
sparser
"g005 KSHV orf10 interacts with USP24 and p53. (A, B) U2OS cells were transfected with pDEST47-KSHV orf10-Flag."
33411764
reach
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
TP53 binds USP24 and orf10. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
TP53 binds USP24 and ORF. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
USP24 activates TP53.
| 5
USP24 activates TP53. 4 / 4
| 4
reach
"It has been shown that USP24 targets p53 to regulate UV induced apoptosis."
29479529
reach
"USP24 targeting DDB2 and p53."
27316462
reach
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10.Novel modulators of p53 signaling encoded by unknown genes of emerging viruses Next, we deleted USP24 gene in U2OS cells using CRISPR and Cas9, which generated three independent US2OS-DeltaUSP24 cell populations upon long-term selection."
33411764
reach
"Evidence that USP24 targets p53 to protect genome stability."
25578727
USP24 activates ubiquitinated TP53. 1 / 1
| 1
reach
"These findings strongly suggest that USP24 directly targets ubiquitinated p53 and removes the ubiquitin moiety, thereby preventing p53 degradation."
25578727
USP24 phosphorylates TP53.
| 1
USP24 leads to the phosphorylation of TP53. 1 / 1
| 1
reach
"(D) KSHV ORF10 expression in USP24 KO cells does not induce accumulation and phosphorylation of p53."
33411764
USP24 decreases the amount of TP53.
| 1
USP24 decreases the amount of TP53. 1 / 1
| 1
reach
"In the absence of MG132 treatment, USP24 depletion reduced the steady state levels of p53 (XREF_FIG, lane 1 vs 2)."
25578727
USP24 affects EP300
| 17 3
USP24 decreases the amount of EP300.
| 2
USP24 decreases the amount of EP300. 2 / 6
| 2
reach
"Knockdown of USP24 decreases Bax and p300 levels, and reduces Ku70 acetylation, thereby preventing cancer cell apoptosis."
27991932
reach
"14 In this study, we found that USP24 downregulation decreased the p300 level, thereby decreasing Ku70 acetylation."
27991932
USP24 binds EP300.
| 2 3
USP24 binds EP300. 5 / 5
| 2 3
reach
"Thus, GFP-USP24 increased p300 protein stability, whereas knockdown USP24 decreased its stability (XREF_FIG; XREF_SUPPLEMENTARY) and USP24 interacted with p300 (XREF_FIG)."
27991932
sparser
"Our previous results also indicated that USP24 can interact with p300, an acetyltransferase that contains a BRD xref , xref ."
33257797
sparser
"Indeed, we observed that USP24 interacts with p300 (Fig.  xref ), and knockdown of USP24 increased p300 ubiquitination, and this effect of USP24 knockdown was abolished after treatment with the proteasome inhibitor MG132 (Fig.  xref )."
30266897
sparser
"Thus, GFP-USP24 increased p300 protein stability, whereas knockdown USP24 decreased its stability ( xref ; xref ) and USP24 interacted with p300 ( xref )."
27991932
reach
"Indeed, we observed that USP24 interacts with p300, and knockdown of USP24 increased p300 ubiquitination, and this effect of USP24 knockdown was abolished after treatment with the proteasome inhibitor MG132."
30266897
USP24 activates EP300.
| 5
USP24 activates EP300. 5 / 5
| 5
reach
"This study shows that USP24 mediates p300, NF-kappaB, DNMT1, and beta-TrCP to regulate IL-6 expression, thus affecting cancer metastasis."
30266897
reach
"Thus, GFP-USP24 increased p300 protein stability, whereas knockdown USP24 decreased its stability (XREF_FIG; XREF_SUPPLEMENTARY) and USP24 interacted with p300 (XREF_FIG)."
27991932
reach
"USP24 induces apoptosis by stabilizing p300 and Bax."
27991932
reach
"In cancer cells, USP24 increased p300 and beta-TrCP, thus increasing the acetylation of histone H3 and the degradation of DNMT1 and IkappaB, resulting in the recruitment of histone H3 acetylation to the promoter region of IL-6, the reduction of DNA methylation, and the promotion of NF-kappaB nuclear translocation, thereby facilitating IL-6 expression."
30266897
reach
"Because our previous study confirmed that p300 is a USP24 substrate in lung cancer cells 31, we wanted to confirm whether p300 is also directly regulated by USP24 in M2 macrophages."
30266897
USP24 increases the amount of EP300.
| 4
USP24 increases the amount of EP300. 3 / 3
| 3
reach
"Up-regulated USP24 increased the protein level of β-TrCP and p300 to promote lung cancer malignancy 31."
34326684
reach
"In M2 macrophages, USP24 increased p300 levels, subsequently enhancing the levels of NF-kappaB and IL-6."
30266897
reach
"Similarly, knockdown of USP24 decreased the p300 level but did not affect its mRNA level (XREF_FIG)."
27991932
Modified USP24 increases the amount of EP300. 1 / 1
| 1
reach
"Overexpression of GFP-USP24 increased the p300 level but did not affect its mRNA level."
27991932
USP24 deubiquitinates EP300.
| 3
USP24 deubiquitinates EP300. 3 / 3
| 3
reach
"USP24 deubiquitinates and stabilizes the histone acetyltransferase p300, thereby facilitating histone H3 acetylation of the IL-6 promoter and thus IL-6 transcription."
33466790
reach
"Indeed, we observed that USP24 interacts with p300, and knockdown of USP24 increased p300 ubiquitination, and this effect of USP24 knockdown was abolished after treatment with the proteasome inhibitor MG132."
30266897
reach
"The in vitro enzymatic assay using the purified USP24 protein demonstrated that USP24 decreased the p300 ubiquitination signal (XREF_FIG)."
27991932
USP24 inhibits EP300.
| 1
USP24 inhibits EP300. 1 / 1
| 1
reach
"Knockdown of USP24 also decreased the protein stability of p300 in M2 macrophages and A549 cancer cells."
30266897
USP24 affects IL6
| 1 17 1
USP24 increases the amount of IL6.
| 11
USP24 increases the amount of IL6. 10 / 10
| 10
reach
"Here, we provide direct evidence to support that USP24 promotes IL-6 expression, which might be beneficial for cancer therapy."
30266897
reach
"In this study, another interesting point is the discovery of distinct molecular mechanisms regulating IL-6 expression in M2 macrophages and lung cancer cells in response to USP24."
30266897
reach
"In this study, we found that USP24 increased IL-6 expression by decreasing the stability of DNMT1 by stabilizing beta-TrCP in lung cancer cells and increasing the stability of p300 in both lung cancer cells and M2 macrophages, thereby resulting in the acetylation of histone H3 and demethylation of the IL-6 promoter, respectively."
30266897
reach
"Finally, we found that knockdown of DNMT1 in USP24-knockdown A549 cells can rescue IL-6 level, suggesting that USP24 mediated DNMT1 degradation is really involved in IL-6 expression."
30266897
reach
"USP24 increases IL-6 expression by epigenetic regulation."
30266897
reach
"In M2 macrophages, USP24 increased p300 levels, subsequently enhancing the levels of NF-kappaB and IL-6."
30266897
reach
"The IL-6 levels secreted from M2 macrophages and A549 cells decreased after USP24 knockdown, suggesting that USP24 upregulation in the tumor associated microenvironment and cancer cells during tumorigenesis increased IL-6 expression."
30266897
reach
"Here, we also observed that USP24 in lung cancer cells increased IL-6 expression."
30266897
reach
"These results indicate that USP24 may upregulate IL-6 expression through directly stabilizing p300 and indirectly induce NF-kappaB expression through p300 in M2 macrophages."
30266897
reach
"In addition to the p300 stabilization induced by USP24 in cancer cells to regulate IL-6 expression through increased histone H3 acetylation, USP24 also reduces DNA methylation in the promoter region of IL-6 in lung cancer cells, but not in M2 macrophages, to increase IL-6 transcription by decreasing DNMT1 protein stability."
30266897
Modified USP24 increases the amount of IL6. 1 / 1
| 1
reach
"While studying the role of USP24 upregulation in M2 macrophages, we found that USP24 expression in M2 macrophages enhanced cancer metastasis by inducing IL-6 expression."
30266897
USP24 activates IL6.
| 1 5
USP24 activates IL6. 6 / 6
| 1 5
reach
"USP24 induces IL-6 in tumor associated microenvironment by stabilizing p300 and beta-TrCP and promotes cancer malignancy."
30266897
reach
"To examine whether USP24 mediated IL-6 was indeed functioning in lung cancer metastasis and angiogenesis, IL-6 was added to conditioned medium derived from USP24-knockdown M2 macrophages to address malignant lung cancer cell activity."
30266897
eidos
"USP24 induces IL-6 in TME through deubiquitinating p300 and beta-TrCP , and whether WP1130 inhibiting USP24 affects IL-6 in TME needs more investigation [ 100 ] ."
33466790
reach
"USP24 induces IL-6 in TME through deubiquitinating p300 and beta-TrCP, and whether WP1130 inhibiting USP24 affects IL-6 in TME needs more investigation [XREF_BIBR]."
33466790
reach
"Adding the physiological dose of IL-6 to the media of USP24-knockdown cells can rescue the effect of USP24 knockdown, suggesting that the USP24 mediated IL-6 in M2 macrophages and in lung cancer is an important factor that affects USP24 induced lung cancer malignancy."
30266897
reach
"IL-6 upregulation by USP24 increases cancer malignancy."
30266897
USP24 methylates IL6.
| 1
USP24 methylates IL6. 1 / 1
| 1
sparser
"After analyzing the five CpG sites upstream of the transcription start site, we found that the methylation status of a CpG site located at −123 was increased in A549 cells but not in M2 macrophages after USP24 knockdown, indicating that a decrease in IL-6 methylation induced by USP24 in A549 cells, but not in M2 macrophages, increases IL-6 mRNA levels."
30266897
USP24 decreases the amount of IL6.
| 1
USP24 decreases the amount of IL6. 1 / 1
| 1
reach
"After analyzing the five CpG sites upstream of the transcription start site, we found that the methylation status of a CpG site located at -123 was increased in A549 cells but not in M2 macrophages after USP24 knockdown, indicating that a decrease in IL-6 methylation induced by USP24 in A549 cells, but not in M2 macrophages, increases IL-6 mRNA levels."
30266897
USP24 affects BAX
| 10 1
USP24 decreases the amount of BAX.
| 2
USP24 decreases the amount of BAX. 2 / 6
| 2
reach
"Knockdown of USP24 decreases Bax and p300 levels, and reduces Ku70 acetylation, thereby preventing cancer cell apoptosis."
27991932
reach
"Knockdown of USP24 decreased the Bax and caspase-3 levels; conversely, these protein levels were increased in GFP-USP24-expressing cells, although no alterations were observed in the Bax mRNA level (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 activates BAX.
| 4
USP24 activates BAX. 4 / 5
| 4
reach
"USP24 induces apoptosis by stabilizing p300 and Bax."
27991932
reach
"In addition, USP24 also directed Bax protein stability to result in cell apoptosis."
27991932
reach
"USP24 knockdown decreases Bax protein stability in A549 and U2OS cells (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
reach
"The localization of Bax in cells expressing GFP-USP24 indicated that USP24 expression increased Bax 's mitochondrial localization, implying that USP24 induced cell apoptosis (XREF_FIG)."
27991932
USP24 binds BAX.
| 1 1
USP24 binds BAX. 2 / 2
| 1 1
reach
"Next, we found that USP24 interacted with Bax (XREF_FIG D)."
27991932
sparser
"Next, we found that USP24 interacted with Bax ( xref D)."
27991932
USP24 inhibits BAX.
| 1
USP24 inhibits ubiquitinated BAX. 1 / 1
| 1
reach
"GFP-USP24 overexpression decreased the ubiquitinated Bax signal, and this effect was reversed by USP24 knockdown (XREF_FIG)."
27991932
USP24 increases the amount of BAX.
| 1
USP24 increases the amount of BAX. 1 / 1
| 1
reach
"MG132 treatment rescued the Bax level, indicating that USP24 increased the Bax level by enhancing protein stability, thereby contributing to cell apoptosis (XREF_SUPPLEMENTARY)."
27991932
USP24 deubiquitinates BAX.
| 1
USP24 deubiquitinates BAX. 1 / 1
| 1
reach
"In agreement with previous reports indicating that USP24 may de-ubiquitinate the pro apoptotic BH3 protein BAX [31], we also observed a decrease in BAX protein levels in USP24 knockdown cells)."
30957634
USP24 affects GSDMB
| 1 11 2
USP24 binds GSDMB.
| 4 2
USP24 binds GSDMB. 6 / 6
| 4 2
reach
"Here, our results indicated that USP24 bound to GSDMB to stabilize GSDMB, and subsequently activated the STAT3 pathway in bladder cancer cells."
34326684
sparser
"USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
sparser
"Furthermore, we also demonstrated that USP24 interacted with GSDMB and prevented GSDMB from degradation in bladder cancer cells."
34326684
reach
"USP24 and GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
reach
"USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
reach
"Furthermore, we also demonstrated that USP24 interacted with GSDMB and prevented GSDMB from degradation in bladder cancer cells."
34326684
USP24 increases the amount of GSDMB.
| 3
USP24 increases the amount of GSDMB. 3 / 3
| 3
reach
"Given that USP24 promoted the expression of the GSDMB protein levels rather than that of the mRNA levels in bladder cancer cells, we hypothesized that USP24 may regulate the stability of GSDMB through the ubiquitinated proteasome pathway."
34326684
reach
"USP24 interacts with GSDMB to up-regulate the GSDMB protein level in bladder cancer."
34326684
reach
"To sum up, USP24 interacts with GSDMB to up-regulate the GSDMB protein level in bladder cancer."
34326684
USP24 inhibits GSDMB.
| 1 1
USP24 bound to GSDMB inhibits GSDMB. 1 / 1
| 1
reach
"Furthermore, we also demonstrated that USP24 interacted with GSDMB and prevented GSDMB from degradation in bladder cancer cells."
34326684
USP24 inhibits GSDMB. 1 / 1
| 1
eidos
"Furthermore , we also demonstrated that USP24 interacted with GSDMB and prevented GSDMB from degradation in bladder cancer cells ."
34326684
USP24 deubiquitinates GSDMB.
| 2
USP24 leads to the deubiquitination of GSDMB. 2 / 2
| 2
reach
"We proved that knocking down or inhibiting USP24 increased the polyubiquitination of GSDMB, but overexpressing USP24 decreased the polyubiquitination of GSDMB in bladder cancer cells (Fig. 6D, H)."
34326684
reach
"Thus, USP24 may mediate the deubiquitination of GSDMB and maintain its stability."
34326684
USP24 activates GSDMB.
| 1
USP24 activates GSDMB. 1 / 1
| 1
reach
"These data suggest that USP24 promoted the stability of the GSDMB protein in bladder cancer by deubiquitinating GSDMB.Moreover, after USP24 was inhibited or overexpressed, the expression level of p-STAT3 Y705 also decreased or increased, respectively (Fig. 6I-K)."
34326684
WP1130 affects USP24
| 10
WP1130 binds USP24.
| 4
USP24 binds WP1130. 4 / 4
| 4
reach
"To elucidate the interaction between WP1130 and USP24, a molecular docking study was performed."
30911287
reach
"In order to investigate whether the WP1130 directly interacts with USP24, a cellular thermal shift assay (CETSA) was conducted [XREF_BIBR, XREF_BIBR]."
30911287
reach
"These data suggest that WP1130 directly interacts with USP24 in T-ALL cells."
30911287
reach
"WP1130 interacts with USP24 in cells."
30911287
WP1130 inhibits USP24.
| 3
WP1130 inhibits USP24. 3 / 3
| 3
reach
"Collectively, these results demonstrate that WP1130 could inhibit T-ALL cell growth and USP24 activity in vivo."
30911287
reach
"The aim of this study was to explore whether WP1130 could suppress T-ALL and the role of USP24 in T-ALL."
30911287
reach
"It should be also noted, however, that G9, as well as WP1130, was recently reported to inhibit USP24 as well as USP5 in addition to USP9X [37]."
32050632
WP1130 activates USP24.
| 2
WP1130 activates USP24. 2 / 2
| 2
reach
"In our study, using CETSA we have shown that WP1130 can direct target USP24 in T-ALL cells."
30911287
reach
"In response to WP1130 treatment, USP24 was upregulated and acted as a compensatory mechanism for USP9x inhibition by WP1130."
29134486
WP1130 decreases the amount of USP24.
| 1
WP1130 decreases the amount of USP24. 1 / 1
| 1
reach
"However, WP1130 did not reduce the mRNA level of USP24 (Additional file 2 : Figure S2)."
30911287
USP24 affects autophagy
| 10
USP24 inhibits autophagy.
| 5
USP24 inhibits autophagy. 5 / 5
| 5
reach
"Furthermore, we observed elevated levels of USP24 in the substantia nigra of a subpopulation of idiopathic PD patients, suggesting that USP24 may negatively regulate autophagy in PD."
30957634
reach
"Consistently, in the original screen [25] USP24 knockdown failed to upregulate autophagy in cells overexpressing BCL-2, which binds and inhibits activity of the class III PtdIns3K subunit BECN1 [34])."
30957634
reach
"Furthermore, our data demonstrate elevated levels of USP24 in some cases of idiopathic PD, suggesting that USP24 may negatively regulate autophagy in PD."
30957634
reach
"Our data indicate that USP24 mRNA and protein levels are also elevated in the substantia nigra of a subset of idiopathic PD patients, suggesting that suppression of autophagy by USP24 could also occur in at least some cases of non familial PD."
30957634
reach
"Therefore, USP24 negatively regulates autophagy flux in human iPSC derived dopaminergic neurons, similarly to what we observed in cell lines."
30957634
USP24 activates autophagy.
| 5
USP24 activates autophagy. 5 / 5
| 5
reach
"Knockdown of USP24 in cell lines and in human induced-pluripotent stem cells (iPSC) differentiated into dopaminergic neurons resulted in elevated ULK1 protein levels and increased autophagy flux in a manner independent of MTORC1 but dependent on the class III phosphatidylinositol 3-kinase (PtdIns3K) activity."
30957634
reach
"Knockdown of USP24 also led to increase in levels of the autophagosome associated lipidated form of LC3 (LC3-II) [30]), confirming increase in autophagy."
30957634
reach
"USP24 is another modulator of autophagy which may also influence PD progression as it can regulate dopaminergic neurite outgrowth, but the potential as a disease modulator is not evaluated yet."
32850842
reach
"Blocking lysosomal function with bafilomycin led to significant increase in accumulation of GFP-LC3 positive autophagosomes in USP24 knockdown cells, indicating that USP24 is negatively regulating autophagy flux without affecting lysosomal degradation)."
30957634
reach
"USP24 is implicated in Parkinson’s disease and increased autophagy , but expression data presented here indicate a role for USP24 in heart, nerve, and muscle tissue, but not adipose or brain tissues."
35501368
USP24 affects PTTG1
| 6 1
USP24 decreases the amount of PTTG1.
| 1
USP24 decreases the amount of PTTG1. 1 / 3
| 1
reach
"Knockdown of USP24 decreased securin expression and increased the securin ubiquitination signal, whereas USP24 overexpression increased securin expression (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 increases the amount of PTTG1.
| 2
USP24 increases the amount of PTTG1. 1 / 1
| 1
reach
"Taken together, our results suggested that USP24 was decreased by APC/C cdc20 to decrease the securin level, which was beneficial for the metaphase-anaphase transition and enhanced cell cycle progression."
27991932
Modified USP24 increases the amount of PTTG1. 1 / 1
| 1
reach
"Knockdown of USP24 decreased securin expression and increased the securin ubiquitination signal, whereas USP24 overexpression increased securin expression (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 binds PTTG1.
| 1 1
USP24 binds PTTG1. 2 / 2
| 1 1
reach
"Here we found that USP24 interacted with securin in mitotic cells (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
sparser
"Here we found that USP24 interacted with securin in mitotic cells ( xref ; xref )."
27991932
USP24 ubiquitinates PTTG1.
| 1
USP24 leads to the ubiquitination of PTTG1. 1 / 1
| 1
reach
"Knockdown of USP24 decreased securin expression and increased the securin ubiquitination signal, whereas USP24 overexpression increased securin expression (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 deubiquitinates PTTG1.
| 1
USP24 leads to the deubiquitination of PTTG1. 1 / 1
| 1
reach
"Knockdown of USP24 decreased securin expression and increased the securin ubiquitination signal, whereas USP24 overexpression increased securin expression (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 affects E2F4
| 7 1
USP24 decreases the amount of E2F4.
| 3
USP24 decreases the amount of E2F4. 2 / 3
| 2
reach
"Knockdown of USP24 decreased the E2F4, p130 and TFDP1 levels, which form a complex to regulate the G1-S transition, but did not alter the E2F4 and TDFP1 mRNA levels (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
reach
"USP24 inhibits the G1-S transition by increasing the E2F4 level."
27991932
Modified USP24 decreases the amount of E2F4. 1 / 1
| 1
reach
"The molecular mechanism involves a decrease in the USP24 level, which reduces the expression of E2F4 and its partner TFDP1, and thus increases the G1/S transition."
27991932
USP24 binds E2F4.
| 1 1
USP24 binds E2F4. 2 / 2
| 1 1
reach
"Further study indicated that USP24 could interact with E2F4 (XREF_FIG)."
27991932
sparser
"Further study indicated that USP24 could interact with E2F4 ( xref )."
27991932
USP24 inhibits E2F4.
| 1
USP24 inhibits E2F4. 1 / 1
| 1
reach
"Knockdown of USP24 decreased E2F4 protein stability (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 deubiquitinates E2F4.
| 1
USP24 leads to the deubiquitination of E2F4. 1 / 1
| 1
reach
"Conversely, knockdown of USP24 in A549 cells increased the E2F4 ubiquitination signal (XREF_FIG)."
27991932
USP24 activates E2F4.
| 1
USP24 activates E2F4. 1 / 1
| 1
reach
"Taken together, our results demonstrated that USP24 knockdown decreased E2F4, p130 and TFDP1, resulting in an increase in the E2F1 levels and a subsequent increase in the G1-S transition, leading to tumorigenesis."
27991932
TRX1 affects USP24
| 5 4
TRX1 binds USP24.
| 4 4
USP24 binds TRX1. 8 / 8
| 4 4
reach
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38 dependent inhibition of apoptosis [84]."
33411764
reach
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38 dependent inhibition of apoptosis [XREF_BIBR]."
33411764
sparser
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38-dependent inhibition of apoptosis [84]."
33411764
sparser
"Overall, these results support the hypothesis that pUL38 binds to USP24 to reduce ferritinophagy, which may then protect cells from lysosome dysfunction induced cell death."
29695420
sparser
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38-dependent inhibition of apoptosis [ xref ]."
33411764
sparser
"Mutant pUL38 TFV/AAA protein did not bind to USP24 and failed to prevent cell death induced by pUL38-deficient HCMV infection."
29695420
reach
"PUL38 binds to ubiquitin specific protease 24 (USP24), a protein that mediates autophagic ferritin degradation in lysosomes."
32765441
reach
"Overall, these results support the hypothesis that pUL38 binds to USP24 to reduce ferritinophagy, which may then protect cells from lysosome dysfunction induced cell death."
29695420
TRX1 inhibits USP24.
| 1
TRX1 inhibits USP24. 1 / 1
| 1
reach
"By interacting with USP24, pUL38 can restrict the functions of USP24 and inhibit ferroptosis, thus promoting the proliferation of HCMV (Sun et al., 2018)."
35572624
Orf10 affects USP24
| 4 4
USP24 binds orf10. 4 / 4
| 4
reach
"https://doi.org/10.1371/journal.ppat.1009033.g005KSHV orf10 interacts with USP24 and p53."
33411764
reach
"KSHV orf10 interacted with the deubiquitinase USP24 and with p53 itself, and p53 is a known substrate for USP24 [XREF_BIBR]."
33411764
reach
"KSHV orf10 interacted with the deubiquitinase USP24 and with p53 itself, and p53 is a known substrate for USP24 [43]."
33411764
reach
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
USP24 binds orf10. 3 / 3
| 3
sparser
"These experiments confirm the prior reports of the KSHV orf10-USP24 interaction in a second, independent cell line."
33411764
sparser
"To test this hypothesis, the published orf10 and USP24 interaction was verified in p53 wild-type U2OS cells."
33411764
sparser
"KSHV orf10 interacted with the deubiquitinase USP24 and with p53 itself, and p53 is a known substrate for USP24 [ xref ]."
33411764
TP53 binds USP24 and orf10. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
USP24 affects apoptotic process
| 1 7
USP24 inhibits apoptotic process.
| 1 3
USP24 inhibits apoptotic process. 4 / 4
| 1 3
reach
"USP24 depletion inhibits apoptosis in response to UV damage."
25578727
reach
"Furthermore, we demonstrated that knockdown of USP24 but not USP9X could significantly induce growth inhibition and apoptosis of T-ALL cells."
30911287
trips
"Silencing USP24 increases the cancer formation by inhibiting cellular apoptosis and increasing cellular proliferation."
27991932
reach
"Depletion of USP24 significantly attenuates p53 dependent apoptosis induced by DNA damage."
25578727
USP24 activates apoptotic process.
| 4
reach
"USP24 induces apoptosis by stabilizing p300 and Bax."
27991932
reach
"Down-regulation of USP24 but not USP9X induces growth inhibition and apoptosis of T-ALL cells."
30911287
reach
"Using this deactivated CRISP-Cas9-SAM system we successfully reactivated USP24 and demonstrate that endogenously induced USP24 could partially rescue the apoptosis induced by WP1130 in Jurkat cells."
30911287
reach
"These results indicate that USP24 promotes UV induced apoptosis in HCT116 cells, consistent with the notion that p53 directed apoptosis is attenuated in USP24 depleted cells which lack robust p53 stabilization after UV treatment."
25578727
USP24 affects XRCC6
| 8
USP24 binds XRCC6.
| 3
USP24 binds XRCC6. 3 / 3
| 3
reach
"15 Herein, we used a yeast two-hybrid assay to study the interaction between Ku70 and USP24 (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
reach
"The data revealed that USP24 interacted with Ku70 (XREF_FIG)."
27991932
reach
"XREF_BIBR, XREF_BIBR Our preliminary results from a yeast two-hybrid assay showed that Ku70 interacts with USP24; however, the role of USP24 in Bax mediated apoptosis is unknown."
27991932
USP24 acetylates XRCC6.
| 3
USP24 leads to the acetylation of XRCC6. 2 / 2
| 2
reach
"Knockdown of USP24 decreases Bax and p300 levels, and reduces Ku70 acetylation, thereby preventing cancer cell apoptosis."
27991932
reach
"14 In this study, we found that USP24 downregulation decreased the p300 level, thereby decreasing Ku70 acetylation."
27991932
Modified USP24 leads to the acetylation of XRCC6. 1 / 1
| 1
reach
"Overexpression or knockdown of USP24 did not affect the Ku70 level but increased or decreased Ku70 acetylation, respectively (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 deacetylates XRCC6.
| 2
Modified USP24 leads to the deacetylation of XRCC6. 1 / 1
| 1
reach
"Overexpression or knockdown of USP24 did not affect the Ku70 level but increased or decreased Ku70 acetylation, respectively (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 leads to the deacetylation of XRCC6. 1 / 1
| 1
reach
"Knockdown of USP24 decreases Bax and p300 levels, and reduces Ku70 acetylation, thereby preventing cancer cell apoptosis."
27991932
USP24 affects TRX1
| 4 4
USP24 binds TRX1. 8 / 8
| 4 4
reach
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38 dependent inhibition of apoptosis [84]."
33411764
reach
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38 dependent inhibition of apoptosis [XREF_BIBR]."
33411764
sparser
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38-dependent inhibition of apoptosis [84]."
33411764
sparser
"Overall, these results support the hypothesis that pUL38 binds to USP24 to reduce ferritinophagy, which may then protect cells from lysosome dysfunction induced cell death."
29695420
sparser
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38-dependent inhibition of apoptosis [ xref ]."
33411764
sparser
"Mutant pUL38 TFV/AAA protein did not bind to USP24 and failed to prevent cell death induced by pUL38-deficient HCMV infection."
29695420
reach
"PUL38 binds to ubiquitin specific protease 24 (USP24), a protein that mediates autophagic ferritin degradation in lysosomes."
32765441
reach
"Overall, these results support the hypothesis that pUL38 binds to USP24 to reduce ferritinophagy, which may then protect cells from lysosome dysfunction induced cell death."
29695420
USP24 affects BTRC
| 7 1
USP24 activates BTRC.
| 3
USP24 activates BTRC. 3 / 3
| 3
reach
"This study shows that USP24 mediates p300, NF-kappaB, DNMT1, and beta-TrCP to regulate IL-6 expression, thus affecting cancer metastasis."
30266897
reach
"To further clarify whether USP24 directly targets beta-TrCP for deubiquitination, an in vitro deubiquitination assay was performed, and purified human USP24 significantly decreased the beta-TrCP ubiquitination signal."
30266897
reach
"In cancer cells, USP24 increased p300 and beta-TrCP, thus increasing the acetylation of histone H3 and the degradation of DNMT1 and IkappaB, resulting in the recruitment of histone H3 acetylation to the promoter region of IL-6, the reduction of DNA methylation, and the promotion of NF-kappaB nuclear translocation, thereby facilitating IL-6 expression."
30266897
USP24 deubiquitinates BTRC.
| 2
USP24 deubiquitinates BTRC. 2 / 2
| 2
reach
"These results provide evidence that USP24 directly deubiquitinates and stabilizes beta-TrCP."
30266897
reach
"To further clarify whether USP24 directly targets beta-TrCP for deubiquitination, an in vitro deubiquitination assay was performed, and purified human USP24 significantly decreased the beta-TrCP ubiquitination signal."
30266897
USP24 binds BTRC.
| 1 1
BTRC binds USP24. 2 / 2
| 1 1
sparser
"Immunoprecipitation analysis confirmed the interaction between USP24 and β-TrCP (Fig.  xref ), and ubiquitinated β-TrCP was significantly increased in USP24-knockdown A549 cells (Fig.  xref and Supplementary Fig.  xref )."
30266897
reach
"Immunoprecipitation analysis confirmed the interaction between USP24 and beta-TrCP, and ubiquitinated beta-TrCP was significantly increased in USP24-knockdown A549 cells."
30266897
USP24 increases the amount of BTRC.
| 1
USP24 increases the amount of BTRC. 1 / 1
| 1
reach
"Up-regulated USP24 increased the protein level of β-TrCP and p300 to promote lung cancer malignancy 31."
34326684
USP24 affects BRD
| 7
USP24 binds BRD. 7 / 7
| 7
sparser
"In this study, we found that the deubiquitinase USP24 interacted with BRD through its C-terminus increased the levels of most BRD-containing proteins through increasing their protein stability by the removal of ubiquitin from Lys391/Lys400 of the BRD."
33257797
sparser
"Loss of the interaction motif of USP24 eliminated the ability of USP24 to stabilize BRD-containing proteins and abolished the effect of USP24 on cancer progression, including its inhibition of cancer cell proliferation and promotion of cancer cell migration, suggesting that the interaction between USP24 and the BRD is important for USP24-mediated effects on cancer progression."
33257797
sparser
"Because USP24 could interact with more than one BRD-containing protein, we hypothesized that USP24 can interact with the BRD, which is common to all BRD-containing proteins."
33257797
sparser
"2153) was sufficient for the interaction between USP24 and BRD (Fig.  xref B)."
33257797
sparser
"Owing to the absence of structural information on the interaction between USP24 and the BRD, we generated a structural model of the catalytic domain of human USP24 (USP24-CD) by using the SWISS-MODEL server, and a complex structural model of the interaction between USP24-CD and the second BRD of human BRD2 (BRD2-BD2) was built up by using the ZDOCK server, which provided a structural view to understand the interactions between USP24-CD and BRD2-BD2 (Fig.  xref G(a))."
33257797
sparser
"Finally, we also used a structural model of USP24 built based on USP7 as a parent template to study the structural interaction between USP24 and the BRD (Fig.  xref G)."
33257797
sparser
"BRD interacts with the C-terminus of USP24."
33257797
TP53 affects USP24
1 | 3 3
TP53 binds USP24.
1 | 1 3
TP53 binds USP24. 3 / 3
1 | 1 1
biogrid
No evidence text available
25578727
sparser
"g005 KSHV orf10 interacts with USP24 and p53. (A, B) U2OS cells were transfected with pDEST47-KSHV orf10-Flag."
33411764
reach
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
TP53 binds USP24 and orf10. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
TP53 binds USP24 and ORF. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
TP53 inhibits USP24.
| 1
TP53 inhibits USP24. 1 / 1
| 1
reach
"These results indicate that USP24 promotes UV induced apoptosis in HCT116 cells, consistent with the notion that p53 directed apoptosis is attenuated in USP24 depleted cells which lack robust p53 stabilization after UV treatment."
25578727
TP53 activates USP24.
| 1
TP53 activates USP24. 1 / 1
| 1
reach
"It has been shown that USP24 targets p53 to regulate UV induced apoptosis."
29479529
BRD affects USP24
| 7
USP24 binds BRD. 7 / 7
| 7
sparser
"In this study, we found that the deubiquitinase USP24 interacted with BRD through its C-terminus increased the levels of most BRD-containing proteins through increasing their protein stability by the removal of ubiquitin from Lys391/Lys400 of the BRD."
33257797
sparser
"Loss of the interaction motif of USP24 eliminated the ability of USP24 to stabilize BRD-containing proteins and abolished the effect of USP24 on cancer progression, including its inhibition of cancer cell proliferation and promotion of cancer cell migration, suggesting that the interaction between USP24 and the BRD is important for USP24-mediated effects on cancer progression."
33257797
sparser
"Because USP24 could interact with more than one BRD-containing protein, we hypothesized that USP24 can interact with the BRD, which is common to all BRD-containing proteins."
33257797
sparser
"2153) was sufficient for the interaction between USP24 and BRD (Fig.  xref B)."
33257797
sparser
"Owing to the absence of structural information on the interaction between USP24 and the BRD, we generated a structural model of the catalytic domain of human USP24 (USP24-CD) by using the SWISS-MODEL server, and a complex structural model of the interaction between USP24-CD and the second BRD of human BRD2 (BRD2-BD2) was built up by using the ZDOCK server, which provided a structural view to understand the interactions between USP24-CD and BRD2-BD2 (Fig.  xref G(a))."
33257797
sparser
"Finally, we also used a structural model of USP24 built based on USP7 as a parent template to study the structural interaction between USP24 and the BRD (Fig.  xref G)."
33257797
sparser
"BRD interacts with the C-terminus of USP24."
33257797
USP24 affects ULK1
| 6
USP24 deubiquitinates ULK1.
| 3
USP24 leads to the deubiquitination of ULK1. 3 / 3
| 3
reach
"We detected increased levels of ULK1 ubiquitination following USP24 knockdown as compared to nt controls)."
30957634
reach
"Our data indicate that USP24 knockdown leads to increase in ULK1 ubiquitination, increased ULK1 protein stability and kinase activity."
30957634
reach
"These data suggest that USP24 normally negatively regulates ubiquitination and stability of ULK1, therefore interrupting the positive feed-back amplifying induction of autophagy."
30957634
USP24 decreases the amount of ULK1.
| 2
USP24 decreases the amount of ULK1. 2 / 2
| 2
reach
"Real time qPCR data revealed no significant change in ULK1 mRNA levels following knockdown of USP24."
30957634
reach
"These data indicate that the observed increase in ULK1 protein levels following USP24 knockdown is not due to transcriptional upregulation."
30957634
USP24 inhibits ULK1.
| 1
USP24 inhibits ULK1. 1 / 1
| 1
reach
"USP24 knockdown decreased degradation of the ULK1 protein in the presence of protein synthesis inhibitor, cycloheximide)."
30957634
GSDMB affects USP24
| 4 2
USP24 binds GSDMB. 6 / 6
| 4 2
reach
"Here, our results indicated that USP24 bound to GSDMB to stabilize GSDMB, and subsequently activated the STAT3 pathway in bladder cancer cells."
34326684
sparser
"USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
sparser
"Furthermore, we also demonstrated that USP24 interacted with GSDMB and prevented GSDMB from degradation in bladder cancer cells."
34326684
reach
"USP24 and GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
reach
"USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
reach
"Furthermore, we also demonstrated that USP24 interacted with GSDMB and prevented GSDMB from degradation in bladder cancer cells."
34326684
EP300 affects USP24
| 3 3
EP300 binds USP24.
| 2 3
USP24 binds EP300. 5 / 5
| 2 3
reach
"Thus, GFP-USP24 increased p300 protein stability, whereas knockdown USP24 decreased its stability (XREF_FIG; XREF_SUPPLEMENTARY) and USP24 interacted with p300 (XREF_FIG)."
27991932
sparser
"Our previous results also indicated that USP24 can interact with p300, an acetyltransferase that contains a BRD xref , xref ."
33257797
sparser
"Indeed, we observed that USP24 interacts with p300 (Fig.  xref ), and knockdown of USP24 increased p300 ubiquitination, and this effect of USP24 knockdown was abolished after treatment with the proteasome inhibitor MG132 (Fig.  xref )."
30266897
sparser
"Thus, GFP-USP24 increased p300 protein stability, whereas knockdown USP24 decreased its stability ( xref ; xref ) and USP24 interacted with p300 ( xref )."
27991932
reach
"Indeed, we observed that USP24 interacts with p300, and knockdown of USP24 increased p300 ubiquitination, and this effect of USP24 knockdown was abolished after treatment with the proteasome inhibitor MG132."
30266897
EP300 activates USP24.
| 1
EP300 activates USP24. 1 / 1
| 1
reach
"Overexpression of HA-p300 abolished the effect of USP24 knockdown on IL-6 expression."
30266897
CDK1 affects USP24
3 | 2 1
CDK1 phosphorylates USP24.
3 | 1 1
CDK1 phosphorylates USP24. 2 / 2
| 1 1
reach
"In this study, we found that the phosphorylation of USP24 by CDK1- or EGF mediated kinase activity decreased the USP24 level."
27991932
sparser
"In this study, we found that the phosphorylation of USP24 by CDK1- or EGF-mediated kinase activity decreased the USP24 level."
27991932
CDK1 phosphorylates USP24 on S2047. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CDK1 phosphorylates USP24 on S2604. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CDK1 phosphorylates USP24 on S1616. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CDK1 decreases the amount of USP24.
| 1
CDK1 decreases the amount of USP24. 1 / 1
| 1
reach
"In this study, we found that the phosphorylation of USP24 by CDK1- or EGF mediated kinase activity decreased the USP24 level."
27991932
USP24 bound to GSDMB activates cell population proliferation. 2 / 2
| 2
reach
"USP24 and GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
reach
"USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
USP24 activates cell population proliferation. 2 / 2
| 2
reach
"Furthermore, knockdown of USP24 markedly inhibits the proliferation of Jurkat cells."
30911287
reach
"It was found that overexpressed USP24 promoted GC cell proliferation and abnormal glycolysis."
37265030
trips
"Silencing USP24 increases the cancer formation by inhibiting cellular apoptosis and increasing cellular proliferation."
27991932
USP24 affects STAT3
| 5
USP24 activates STAT3.
| 3
USP24 activates STAT3. 2 / 2
| 2
reach
"Besides, we also showed that USP24 stabilized GSDMB to activate STAT3 signaling, which was blocked by the USP24 inhibitor.Conclusions: We suggested that aberrantly up-regulated GSDMB was responsible for enhancing the growth and invasion ability of bladder cancer cells."
34326684
reach
"Besides, we also showed that USP24 stabilized GSDMB to activate STAT3 signaling, which was blocked by the USP24 inhibitor."
34326684
USP24 bound to GSDMB activates STAT3. 1 / 1
| 1
reach
"Here, our results indicated that USP24 bound to GSDMB to stabilize GSDMB, and subsequently activated the STAT3 pathway in bladder cancer cells."
34326684
USP24 phosphorylates STAT3.
| 2
USP24 leads to the phosphorylation of STAT3. 2 / 2
| 2
reach
"USP24 stabilizes GSDMB to promote STAT3 phosphorylation in bladder cancer cells."
34326684
reach
"In conclusion, USP24 stabilizes GSDMB to promote STAT3 phosphorylation in bladder cancer cells (Fig. 6L)."
34326684
USP24 affects DNMT1
| 5
USP24 inhibits DNMT1.
| 3
USP24 inhibits DNMT1. 3 / 3
| 3
reach
"In this study, we observed that USP24 increased DNMT1 degradation in cancer cells, but not in M2 macrophages, leading to decreased DNA methylation."
30266897
reach
"Finally, we found that knockdown of DNMT1 in USP24-knockdown A549 cells can rescue IL-6 level, suggesting that USP24 mediated DNMT1 degradation is really involved in IL-6 expression."
30266897
reach
"USP24 decreases DNMT1 and IkappaB through stabilizing beta-TrCP."
30266897
USP24 decreases the amount of DNMT1.
| 1
USP24 decreases the amount of DNMT1. 1 / 1
| 1
reach
"beta-TrCP overexpression in USP24-knockdown cells prevented the upregulation of DNMT1and IkappaB induced by USP24 knockdown and demonstrated that beta-TrCP is critical in the USP24 induced increase of DNMT1 and IkappaB expression."
30266897
USP24 activates DNMT1.
| 1
USP24 activates DNMT1. 1 / 1
| 1
reach
"This study shows that USP24 mediates p300, NF-kappaB, DNMT1, and beta-TrCP to regulate IL-6 expression, thus affecting cancer metastasis."
30266897
USP24 affects CDC20
| 3 2
USP24 binds CDC20.
| 2 2
USP24 binds CDC20. 4 / 4
| 2 2
reach
"Moreover, cdc20 could also interact with USP24 when these residues were phosphorylated, implying that the decrease in USP24 during mitosis might be important for cell cycle progression and cancer cell proliferation (XREF_FIG)."
27991932
reach
"Further study found that USP24 interacted with cdc20 during the mitotic stage (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
sparser
"Moreover, cdc20 could also interact with USP24 when these residues were phosphorylated, implying that the decrease in USP24 during mitosis might be important for cell cycle progression and cancer cell proliferation ( xref )."
27991932
sparser
"Further study found that USP24 interacted with cdc20 during the mitotic stage ( xref ; xref )."
27991932
USP24 activates CDC20.
| 1
USP24 activates CDC20. 1 / 1
| 1
reach
"USP24 phosphorylation increased the recruitment of the E3 ligase cdc20, which is the subunit of the APC/C complex that provides the E3 ligase activity."
27991932
USP9X affects USP24
| 3 1
USP9X inhibits USP24.
| 3
USP9X inhibits USP24. 3 / 3
| 3
reach
"In order to determine whether USP9X promote the degradation of USP24, we over-expressed USP9X in 293T cells and examined the protein level of USP24."
30911287
reach
"Moreover, the decreasing of USP24 could be rescued by MG132, indicating that USP9X can promote the degradation of USP24."
30911287
reach
"Usp9x depletion induced upregulation of Usp24 which has shown to be involved in myeloma cell survival."
31979059
USP9X binds USP24.
| 1
USP24 binds USP9X and NOTCH1. 1 / 1
| 1
sparser
"Indeed, our pull-down studies for NOTCH1, followed by detection of USP24 and USP9x in western blot experiments, showed that neither USP9x nor USP24 interact with NOTCH1 ( xref )."
30224337
USP24 affects WP1130
| 4
USP24 binds WP1130. 4 / 4
| 4
reach
"To elucidate the interaction between WP1130 and USP24, a molecular docking study was performed."
30911287
reach
"In order to investigate whether the WP1130 directly interacts with USP24, a cellular thermal shift assay (CETSA) was conducted [XREF_BIBR, XREF_BIBR]."
30911287
reach
"These data suggest that WP1130 directly interacts with USP24 in T-ALL cells."
30911287
reach
"WP1130 interacts with USP24 in cells."
30911287
USP24 affects USP24
| 3
USP24 increases the amount of USP24.
| 1
USP24 increases the amount of USP24. 1 / 2
| 1
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR Our recent study showed that USP24 variants from SNPs and RNA editing products increased the levels of USP24 and MDM2, which regulates Suv39h1 in lung cancer cells, subsequently resulting in an increase in metastatic activities during lung cancer progression."
27991932
USP24 inhibits USP24.
| 1
USP24 inhibits USP24. 1 / 1
| 1
reach
"Here we found that the phosphorylation of several USP24 residues was regulated by EGF treatment and mitotic CDK1 to enhance USP24 degradation in a polyubiquitination dependent manner."
27991932
USP24 decreases the amount of USP24.
| 1
Phosphorylated USP24 decreases the amount of USP24. 1 / 1
| 1
reach
"Mutations at these residues increased the USP24 half-life during mitosis, suggesting that USP24 phosphorylation during mitosis decreased USP24 expression (XREF_FIG)."
27991932
USP24 affects NFkappaB
| 3 1
USP24 activates NFkappaB.
| 2 1
USP24 activates NFkappaB. 3 / 3
| 2 1
sparser
"However, in this study, USP24-activated NF-κB did not increase CCL2, implying that other factors regulated by USP24 might negatively regulate CCL2 expression."
30266897
reach
"In this study, we discovered the underlying mechanisms by which USP24 not only promotes IkappaB degradation by stabilizing beta-transduction repeat containing E3 ubiquitin protein ligase (beta-TrCP) in lung cancer cells but also induces the upregulation of NF-kappaB in M2 macrophages, resulting in an increase in IL-6 expression."
30266897
reach
"This study shows that USP24 mediates p300, NF-kappaB, DNMT1, and beta-TrCP to regulate IL-6 expression, thus affecting cancer metastasis."
30266897
USP24 increases the amount of NFkappaB.
| 1
USP24 increases the amount of NFkappaB. 1 / 1
| 1
reach
"In M2 macrophages, USP24 increased p300 levels, subsequently enhancing the levels of NF-kappaB and IL-6."
30266897
USP24 affects IKB
| 4
USP24 inhibits IKB.
| 3
USP24 inhibits IKB. 3 / 3
| 3
reach
"beta-TrCP overexpression in USP24-knockdown cells prevented the upregulation of DNMT1and IkappaB induced by USP24 knockdown and demonstrated that beta-TrCP is critical in the USP24 induced increase of DNMT1 and IkappaB expression."
30266897
reach
"In this study, we discovered the underlying mechanisms by which USP24 not only promotes IkappaB degradation by stabilizing beta-transduction repeat containing E3 ubiquitin protein ligase (beta-TrCP) in lung cancer cells but also induces the upregulation of NF-kappaB in M2 macrophages, resulting in an increase in IL-6 expression."
30266897
reach
"USP24 decreases DNMT1 and IkappaB through stabilizing beta-TrCP."
30266897
USP24 increases the amount of IKB.
| 1
USP24 increases the amount of IKB. 1 / 1
| 1
reach
"beta-TrCP overexpression in USP24-knockdown cells prevented the upregulation of DNMT1and IkappaB induced by USP24 knockdown and demonstrated that beta-TrCP is critical in the USP24 induced increase of DNMT1 and IkappaB expression."
30266897
USP24 affects BRD7
| 4
USP24 binds BRD7. 3 / 3
| 3
sparser
"The data indicated that BRD7 interacted with full-length USP24 and the C-terminus of USP24, USP24-(4), but not USP24-(1-2-3), which is consistent with the results of the yeast two-hybrid assay."
33257797
sparser
"First, we found that endogenous USP24 could interact with BRD7 in H1299 cells and mouse embryonic fibroblasts (MEFs) (Fig.  xref A and Suppl."
33257797
sparser
"Therefore, we first constructed an N-terminal USP24 construct, USP24-(1-2–3) and a C-terminal USP24 construct, USP24-(4), to study the interaction of USP24 with BRD7 (Fig.  xref A,C)."
33257797
SMARCA4 binds USP24 and BRD7. 1 / 1
| 1
sparser
"Next, when HA-BRD7 and HA-BRG1 were expressed in H1299 cells or MEFs, we found that USP24 interacted with BRD7 and BRG1, indicating that USP24 could interact with more than one BRD-containing protein in different cell lines (Fig.  xref B,C and Suppl."
33257797
KRAS affects USP24
| 4
KRAS-G12D decreases the amount of USP24. 3 / 3
| 3
reach
"Taken together, these data revealed that Kras G12D - or EGFR L858R -mediated pathways negatively regulated USP24 expression, which might trigger lung cancer formation."
27991932
reach
"XREF_BIBR, XREF_BIBR Although their levels were increased in some specimens from late-stage lung cancer patients, inhibition of Kras G12D - or EGFR L858R -mediated activities in all cell lines at different stages increased the USP24 level."
27991932
reach
"Based on the data in this study and our previous study, we propose that EGFR L858R - and Kras G12D -mediated signaling pathways inhibit USP24 expression, which is beneficial for cancer formation during the early stage."
27991932
KRAS decreases the amount of USP24. 1 / 1
| 1
reach
"Furthermore, the data in XREF_FIG indicated that USP24 expression was also negatively regulated by EGFR- and Kras activated signaling pathways."
27991932
EOAI3402143 affects USP24
| 1 3
EOAI3402143 inhibits USP24. 4 / 4
| 1 3
reach
"Furthermore, we improved the drug like properties of WP1130 and demonstrated that the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice."
25814533
reach
"The novel inhibitor EOAI3402143 proved to inhibit both Usp9x and Usp24 activity and suppresses tumor growth in vivo [XREF_BIBR]."
27261328
eidos
"Another novel small molecule , EOAI3402143 ( with properties similar to WP1130 ) , selectively inhibits USP9X and USP24 , induces apoptosis in malignant B-cell lines , and also blocks or regresses myeloma tumors in mice [ 127 ] ."
32354135
reach
"A more novel inhibitor EOAI3402143 inhibited Usp9x and Usp24 activity in a dose dependent manner and resulted in the induction of apoptosis."
26695547
CDC20 affects USP24
| 2 2
USP24 binds CDC20. 4 / 4
| 2 2
reach
"Moreover, cdc20 could also interact with USP24 when these residues were phosphorylated, implying that the decrease in USP24 during mitosis might be important for cell cycle progression and cancer cell proliferation (XREF_FIG)."
27991932
reach
"Further study found that USP24 interacted with cdc20 during the mitotic stage (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
sparser
"Moreover, cdc20 could also interact with USP24 when these residues were phosphorylated, implying that the decrease in USP24 during mitosis might be important for cell cycle progression and cancer cell proliferation ( xref )."
27991932
sparser
"Further study found that USP24 interacted with cdc20 during the mitotic stage ( xref ; xref )."
27991932
BRD7 affects USP24
| 4
USP24 binds BRD7. 3 / 3
| 3
sparser
"The data indicated that BRD7 interacted with full-length USP24 and the C-terminus of USP24, USP24-(4), but not USP24-(1-2-3), which is consistent with the results of the yeast two-hybrid assay."
33257797
sparser
"First, we found that endogenous USP24 could interact with BRD7 in H1299 cells and mouse embryonic fibroblasts (MEFs) (Fig.  xref A and Suppl."
33257797
sparser
"Therefore, we first constructed an N-terminal USP24 construct, USP24-(1-2–3) and a C-terminal USP24 construct, USP24-(4), to study the interaction of USP24 with BRD7 (Fig.  xref A,C)."
33257797
SMARCA4 binds USP24 and BRD7. 1 / 1
| 1
sparser
"Next, when HA-BRD7 and HA-BRG1 were expressed in H1299 cells or MEFs, we found that USP24 interacted with BRD7 and BRG1, indicating that USP24 could interact with more than one BRD-containing protein in different cell lines (Fig.  xref B,C and Suppl."
33257797
ATM affects USP24
| 2 1
ATM activates USP24.
| 2
ATM activates USP24. 2 / 3
| 2
reach
"Moreover, UV induced USP24 accumulation appears to be ATM dependent; inhibition of ATM by either KU-55933 or a specific siRNA prevented USP24 accumulation after UV (XREF_FIG)."
25578727
reach
"Taken together, these data suggest that the ATM kinase mediated phosphorylation of USP24 is involved in USP24 stabilization/up regulation following UV irradiation."
25578727
ATM phosphorylates USP24.
| 1
ATM phosphorylates USP24. 1 / 1
| 1
sparser
"Taken together, these data suggest that the ATM kinase-mediated phosphorylation of USP24 is involved in USP24 stabilization/up-regulation following UV irradiation."
25578727
Bisphenol A affects USP24
3 |
Bisphenol A decreases the amount of USP24.
2 |
Bisphenol A decreases the amount of USP24. 2 / 2
2 |
ctd
No evidence text available
25181051
ctd
No evidence text available
28628672
Bisphenol A increases the amount of USP24.
1 |
Bisphenol A increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
30816183
XRCC6 affects USP24
| 3
USP24 binds XRCC6. 3 / 3
| 3
reach
"15 Herein, we used a yeast two-hybrid assay to study the interaction between Ku70 and USP24 (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
reach
"The data revealed that USP24 interacted with Ku70 (XREF_FIG)."
27991932
reach
"XREF_BIBR, XREF_BIBR Our preliminary results from a yeast two-hybrid assay showed that Ku70 interacts with USP24; however, the role of USP24 in Bax mediated apoptosis is unknown."
27991932
reach
"In conclusion, USP24 was upregulated in GC and promoted the growth and glycolysis of GC cells, the mechanism of which was related to the deubiquitination of PLK1 and the increase of its stability."
37265030
reach
"Ubiquitin-specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1."
37265030
reach
"It was found that overexpressed USP24 promoted GC cell proliferation and abnormal glycolysis."
37265030
USP24 affects cell death
| 3
USP24 activates cell death.
| 2
USP24 activates cell death. 2 / 2
| 2
reach
"GFP-USP24 expression, but not GFP, led to rounded cells and, finally, cell death."
27991932
reach
"Direct Usp24 KD resulted in marked induction of myeloma cell death that was associated with a reduction of Mcl-1."
25814533
USP24 inhibits cell death.
| 1
USP24 inhibits cell death. 1 / 1
| 1
reach
"Knockdown of USP24 suppressed the cell death during pUL38 deficient HCMV infection, suggesting that pUL38 achieved its function by antagonizing the function of USP24."
29695420
USP24 affects TFDP1
| 3
USP24 increases the amount of TFDP1.
| 1
Modified USP24 increases the amount of TFDP1. 1 / 1
| 1
reach
"The molecular mechanism involves a decrease in the USP24 level, which reduces the expression of E2F4 and its partner TFDP1, and thus increases the G1/S transition."
27991932
USP24 decreases the amount of TFDP1.
| 1
USP24 decreases the amount of TFDP1. 1 / 1
| 1
reach
"Knockdown of USP24 decreased the E2F4, p130 and TFDP1 levels, which form a complex to regulate the G1-S transition, but did not alter the E2F4 and TDFP1 mRNA levels (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 activates TFDP1.
| 1
USP24 activates TFDP1. 1 / 1
| 1
reach
"Taken together, our results demonstrated that USP24 knockdown decreased E2F4, p130 and TFDP1, resulting in an increase in the E2F1 levels and a subsequent increase in the G1-S transition, leading to tumorigenesis."
27991932
USP24 affects Stomach Neoplasms
| 3
reach
"Silencing USP24 inhibited the GC process."
37265030
reach
"In conclusion, USP24 was upregulated in GC and promoted the growth and glycolysis of GC cells, the mechanism of which was related to the deubiquitination of PLK1 and the increase of its stability."
37265030
reach
"It was found that overexpressed USP24 promoted GC cell proliferation and abnormal glycolysis."
37265030
USP24 affects SQSTM1
| 3
USP24 activates SQSTM1.
| 2
USP24 activates SQSTM1. 2 / 2
| 2
reach
"Knockdown of USP24 increased the rate of degradation of the autophagy adaptor protein SQSTM1 and p62)."
30957634
reach
"Knockdown of USP24 increased the rate of degradation of the autophagy adaptor protein SQSTM1 and p62)."
30957634
USP24 increases the amount of SQSTM1.
| 1
USP24 increases the amount of SQSTM1. 1 / 1
| 1
reach
"Decrease in SQSTM1 levels following USP24 knockdown was attenuated in the presence of bafilomycin, confirming dependence on lysosomal degradation)."
30957634
USP24 affects Parkinson Disease
| 3
USP24 inhibits Parkinson Disease. 3 / 3
| 3
reach
"The USP24 T allele also seemed to reduce PD risk independently in the group> = 60 years (OR = 0.64, 95% CI 0.44-0.91, P = 0.023)."
20302855
reach
"Interestingly, it has been reported that some polymorphisms of USP24 and USP40 significantly decrease the risk of developing PD [22,23]."
26797011
reach
"Our results demonstrated that USP24 rs487230 T allele and CT/TT genotype notably decreased the risk of developing PD in the AAO> = 60 year subgroup of patients."
20302855
USP24 affects PARP1
| 3
USP24 inhibits PARP1.
| 2
USP24 inhibits PARP1. 2 / 2
| 2
reach
"In p53 +/+ cells, cleaved PARP started to appear as early as three hours after UV irradiation and depletion of USP24 resulted in slow and reduced PARP cleavage (XREF_FIG, right panel)."
25578727
reach
"USP24 depletion inhibits PUMA activation and PARP cleavage in response to UV damage."
25578727
USP24 activates PARP1.
| 1
USP24 activates PARP1. 1 / 1
| 1
reach
"To examine whether USP24 regulates the apoptotic response to UV through the p53 pathway, we compared the effects of USP24 depletion on UV induced PARP cleavage in two isogenic cell lines : HCT116 p53 +/+ and HCT116 p53-/-."
25578727
ORF10 affects USP24
1 | 2
ORF10 activates USP24.
| 2
ORF10 activates USP24. 2 / 2
| 2
eidos
"In the presence of etoposide , USP24 was no longer induced by KSHV ORF10 , as it was deleted , and p53 levels were reduced in KSHV orf10 expressing as compared to untransfected control ."
33411764
eidos
"In the presence of etoposide , USP24 was no longer induced by KSHV ORF10 , as it was deleted , and p53 levels were reduced in KSHV orf10 expressing as Novel modulators of p53-signaling encoded by unknown genes of emerging viruses compared to untransfected control ."
33411764
ORF10 binds USP24.
1 |
USP24 binds ORF10. 1 / 1
1 |
virhostnet
No evidence text available
25544563
ERK affects USP24
| 2 1
ERK binds USP24.
| 1 1
ERK binds USP24. 2 / 2
| 1 1
reach
"Further study indicated that USP24 could interact with Erk1/2 and p-Erk1/2 (XREF_FIG), suggesting that Erk1/2 might be the kinase for phosphorylation of USP24 at S2604 to decrease the USP24 level."
27991932
sparser
"Further study indicated that USP24 could interact with Erk1/2 and p-Erk1/2 ( xref ), suggesting that Erk1/2 might be the kinase for phosphorylation of USP24 at S2604 to decrease the USP24 level."
27991932
ERK phosphorylates USP24.
| 1
ERK phosphorylates USP24. 1 / 1
| 1
reach
"In addition to the phosphorylation of USP24 in mitosis, USP24 is also phosphorylated by EGF activated Erk1/2 kinase activity to turnover USP24."
27991932
EGFR affects USP24
| 3
EGFR decreases the amount of USP24.
| 2
EGFR-L858R decreases the amount of USP24. 1 / 1
| 1
reach
"Taken together, these data revealed that Kras G12D - or EGFR L858R -mediated pathways negatively regulated USP24 expression, which might trigger lung cancer formation."
27991932
EGFR decreases the amount of USP24. 1 / 1
| 1
reach
"Furthermore, the data in XREF_FIG indicated that USP24 expression was also negatively regulated by EGFR- and Kras activated signaling pathways."
27991932
EGFR inhibits USP24.
| 1
Mutated EGFR inhibits USP24. 1 / 1
| 1
reach
"Therefore, during the initiation of tumor formation, EGFR mutations decrease USP24 to increase the degradation of p300 and Bax, and thus repress cell apoptosis."
27991932
EGF affects USP24
| 3
EGF phosphorylates USP24.
| 2
EGF phosphorylates USP24. 2 / 2
| 2
reach
"In this study, we found that the phosphorylation of USP24 by CDK1- or EGF mediated kinase activity decreased the USP24 level."
27991932
reach
"In addition to the phosphorylation of USP24 in mitosis, USP24 is also phosphorylated by EGF activated Erk1/2 kinase activity to turnover USP24."
27991932
EGF decreases the amount of USP24.
| 1
EGF decreases the amount of USP24. 1 / 1
| 1
reach
"In this study, we found that the phosphorylation of USP24 by CDK1- or EGF mediated kinase activity decreased the USP24 level."
27991932
E2F4 affects USP24
| 2 1
E2F4 binds USP24.
| 1 1
USP24 binds E2F4. 2 / 2
| 1 1
reach
"Further study indicated that USP24 could interact with E2F4 (XREF_FIG)."
27991932
sparser
"Further study indicated that USP24 could interact with E2F4 ( xref )."
27991932
E2F4 activates USP24.
| 1
Modified E2F4 activates USP24. 1 / 1
| 1
reach
"Overexpression of E2F4 in USP24 silenced cells rescued only the E2F1 mRNA level and partially abolished the effect of the USP24 knockdown on the G1-S transition and colony formation (XREF_FIG; XREF_SUPPLEMENTARY), implying that E2F4 might be involved in USP24 mediated cell cycle progression."
27991932
BTRC affects USP24
| 2 1
BTRC binds USP24.
| 1 1
BTRC binds USP24. 2 / 2
| 1 1
sparser
"Immunoprecipitation analysis confirmed the interaction between USP24 and β-TrCP (Fig.  xref ), and ubiquitinated β-TrCP was significantly increased in USP24-knockdown A549 cells (Fig.  xref and Supplementary Fig.  xref )."
30266897
reach
"Immunoprecipitation analysis confirmed the interaction between USP24 and beta-TrCP, and ubiquitinated beta-TrCP was significantly increased in USP24-knockdown A549 cells."
30266897
BTRC activates USP24.
| 1
BTRC activates USP24. 1 / 1
| 1
reach
"In addition, beta-TrCP overexpression can abolish the effect of USP24 knockdown in IL-6 expression."
30266897
Valproic acid affects USP24
2 |
Valproic acid decreases the amount of USP24. 2 / 2
2 |
ctd
No evidence text available
28001369
ctd
No evidence text available
23179753
Cisplatin affects USP24
2 |
Cisplatin decreases the amount of USP24. 2 / 2
2 |
ctd
No evidence text available
27392435
ctd
No evidence text available
27594783
Benzo[a]pyrene diol epoxide I decreases the amount of USP24. 2 / 2
2 |
ctd
No evidence text available
19150397
ctd
No evidence text available
26238291
USP24 affects cell cycle
| 2
USP24 inhibits cell cycle.
| 1
USP24 inhibits cell cycle. 1 / 1
| 1
reach
"In addition, knockdown of USP24 increases cell cycle progression by enhancing the G1-S transition and metaphase-anaphase transition."
27991932
USP24 activates cell cycle.
| 1
USP24 activates cell cycle. 1 / 1
| 1
reach
"Overexpression of E2F4 in USP24 silenced cells rescued only the E2F1 mRNA level and partially abolished the effect of the USP24 knockdown on the G1-S transition and colony formation (XREF_FIG; XREF_SUPPLEMENTARY), implying that E2F4 might be involved in USP24 mediated cell cycle progression."
27991932
USP24 affects activation IFNbeta
| 2
USP24 inhibits activation IFNbeta. 2 / 2
| 2
eidos
"Moreover , USP2-4 , but not USP2-1 , attenuated the activation of IFNbeta promoter after SeV infection , indicating a role for USP2 in suppressing viral immunity [ 155 ] ."
33530560
eidos
"USP2-4 also inhibited the activation of the IFNbeta promoter by modulating retinoic acid-inducible gene-I ( RIG-I ) , melanoma differentiation-associated gene 5 ( MDA5 ) , mitochondrial antiviral signaling protein ( MAVS ) , TANK binding kinase 1 ( TBK1 ) , and possibly activating interferon regulatory factor 3 ( IRF3 ) [ 155 ] ."
33530560
USP24 affects USP9X
| 1 1
USP24 increases the amount of USP9X.
| 1
USP24 increases the amount of USP9X. 1 / 1
| 1
reach
"Interestingly, knockdown of USP24 in Jurkat cells significantly induced cell death and reduced Mcl-1 but not USP9X protein level."
30911287
USP24 binds USP9X.
| 1
USP24 binds USP9X and NOTCH1. 1 / 1
| 1
sparser
"Indeed, our pull-down studies for NOTCH1, followed by detection of USP24 and USP9x in western blot experiments, showed that neither USP9x nor USP24 interact with NOTCH1 ( xref )."
30224337
USP24 affects TBK1
| 1 1
USP24 inhibits TBK1.
| 1
USP24 inhibits TBK1. 1 / 1
| 1
reach
"Knockdown of USP24 upregulated TBK1 K63-linked polyubiquitination, promoted the phosphorylation and nuclear translocation of IRF3, and in turn improved IFN-I production during EV71 infection."
36334706
USP24 binds TBK1.
| 1
TBK1 binds USP24. 1 / 1
| 1
sparser
"Further studies revealed that USP24 physically interacted with TBK1, and can reduce K63-linked polyubiquitination of TBK1."
36334706
USP24 affects SUV39H1
1 | 1
USP24 increases the amount of SUV39H1.
| 1
USP24 increases the amount of SUV39H1. 1 / 1
| 1
reach
"USP24 was also found to target histones by controlling the levels of the histone-lysine N-methyltransferase Suv39h1, resulting in a modulation of the H3K9me levels."
27516771
USP24 binds SUV39H1.
1 |
SUV39H1 binds USP24. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP24 affects RUNX2
| 2
USP24 decreases the amount of RUNX2.
| 1
USP24 decreases the amount of RUNX2. 1 / 1
| 1
reach
"However, unlike HAUSP, USP24 was unable to interact with RUNX2 and reduce ubiquitination levels of RUNX2, suggesting that HAUSP, not USP24, functions as a bona-fide RUNX2-DUB."
32385263
USP24 binds RUNX2.
| 1
RUNX2 binds USP24. 1 / 1
| 1
reach
"To examine endogenous interaction between RUNX2 and CK2 or USP24, cell lysates were obtained from mouse COBs and prepared in lysis buffer (50mM Tris-HCl (pH 7.4), 150mM NaCl, 1% Triton X-100, 1mM EDTA, 1mM EGTA, 50mM NaF, 1mM Na 3 VO 4, 1mM PMSF, and protease inhibitor cocktail (Sigma))."
32385263
USP24 affects RP2
2 |
RP2 binds USP24. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP24 affects RHOJ
2 |
USP24 binds RHOJ. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
USP24 affects PLK1
| 2
USP24 increases the amount of PLK1.
| 1
USP24 increases the amount of PLK1. 1 / 1
| 1
reach
"Further analysis and study showed that USP24 could promote the stability and increase the expression of oncogene PLK1."
37265030
USP24 activates PLK1.
| 1
USP24 activates PLK1. 1 / 1
| 1
reach
"Ubiquitin-specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1."
37265030
USP24 affects Neoplasms
| 1
USP24 activates Neoplasms. 1 / 2
| 1
reach
"Ubiquitin-specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1."
37265030
USP24 activates Neoplasm Metastasis. 2 / 2
| 2
reach
"These findings further implied that NF-kappaB is indeed involved in USP24 promoted metastasis."
30266897
reach
"After IL-6 was added to the M2 macrophages conditioned medium, this effect was rescued, indicating that the USP24 induced metastasis activity is due to upregulated IL-6, which can be expressed by M2 macrophages or cancer cells."
30266897
USP24 affects MDM2
| 2
USP24 increases the amount of MDM2. 2 / 2
| 2
reach
"Intriguingly, USP24 up-regulates the expression of MDM2, the well-known E3 ligase of P53, in lung cancer, which contradicts the above finding 31."
34326684
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR Our recent study showed that USP24 variants from SNPs and RNA editing products increased the levels of USP24 and MDM2, which regulates Suv39h1 in lung cancer cells, subsequently resulting in an increase in metastatic activities during lung cancer progression."
27991932
USP24 affects LYPD3
2 |
USP24 binds LYPD3. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP24 affects Ku-70
| 2
USP24 binds Ku-70. 2 / 2
| 2
sparser
"Previous studies indicated that Ku70 was involved in Bax mitochondrial translocation. xref Herein, we used a yeast two-hybrid assay to study the interaction between Ku70 and USP24 ( xref ; xref )."
27991932
sparser
"The data revealed that USP24 interacted with Ku70 ( xref )."
27991932
USP24 affects Histone
| 2
USP24 deacetylates Histone.
| 1
USP24 leads to the deacetylation of Histone. 1 / 1
| 1
reach
"The results showed that silencing USP24 in lung cancer cells decreased histone 3 acetylation at the IL-6 promoter region, implying that the transcriptional activity of IL-6 is inhibited by USP24 knockdown."
30266897
USP24 acetylates Histone.
| 1
USP24 leads to the acetylation of Histone. 1 / 1
| 1
reach
"The silencing of USP24 in M2 macrophages decreased histone 3 acetylation at the promoter regions of NF-kappaB and IL-6, implying that NF-kappaB and IL-6 transcription were inhibited after USP24 knockdown."
30266897
USP24 affects GSDMB protein bladder cancer
| 2
USP24 activates GSDMB protein bladder cancer. 2 / 2
| 2
eidos
"USP24 interacts with GSDMB to up-regulate the GSDMB protein level in bladder cancer After revealing the important role of GSDMB in bladder cancer , we studied how GSDMB was regulated in bladder cancer for the targeted treatment of bladder cancer ."
34326684
eidos
"To sum up , USP24 interacts with GSDMB to up-regulate the GSDMB protein level in bladder cancer ."
34326684
USP24 affects ERK
| 1 1
ERK binds USP24. 2 / 2
| 1 1
reach
"Further study indicated that USP24 could interact with Erk1/2 and p-Erk1/2 (XREF_FIG), suggesting that Erk1/2 might be the kinase for phosphorylation of USP24 at S2604 to decrease the USP24 level."
27991932
sparser
"Further study indicated that USP24 could interact with Erk1/2 and p-Erk1/2 ( xref ), suggesting that Erk1/2 might be the kinase for phosphorylation of USP24 at S2604 to decrease the USP24 level."
27991932
USP24 affects Cyclin
| 2
Modified USP24 increases the amount of Cyclin. 1 / 1
| 1
reach
"Overexpression of GFP-USP24 increased the cyclin B1 level, suggesting that USP24 was beneficial for cells that remained in mitosis (XREF_SUPPLEMENTARY)."
27991932
USP24 increases the amount of Cyclin. 1 / 1
| 1
reach
"Knockdown of USP24 increased the CDK1 and cyclin B1 levels, and increased the ratio of cells in the G2/M stage, indicating that USP24 reduction was beneficial for cell cycle progression (XREF_SUPPLEMENTARY)."
27991932
USP24 affects CCNB1
| 2
Modified USP24 increases the amount of CCNB1. 1 / 1
| 1
reach
"Overexpression of GFP-USP24 increased the cyclin B1 level, suggesting that USP24 was beneficial for cells that remained in mitosis (XREF_SUPPLEMENTARY)."
27991932
USP24 increases the amount of CCNB1. 1 / 1
| 1
reach
"Knockdown of USP24 increased the CDK1 and cyclin B1 levels, and increased the ratio of cells in the G2/M stage, indicating that USP24 reduction was beneficial for cell cycle progression (XREF_SUPPLEMENTARY)."
27991932
USP24 affects BCAR1
| 2
USP24 decreases the amount of BCAR1.
| 1
USP24 decreases the amount of BCAR1. 1 / 1
| 1
reach
"Knockdown of USP24 decreased the E2F4, p130 and TFDP1 levels, which form a complex to regulate the G1-S transition, but did not alter the E2F4 and TDFP1 mRNA levels (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 activates BCAR1.
| 1
USP24 activates BCAR1. 1 / 1
| 1
reach
"Taken together, our results demonstrated that USP24 knockdown decreased E2F4, p130 and TFDP1, resulting in an increase in the E2F1 levels and a subsequent increase in the G1-S transition, leading to tumorigenesis."
27991932
USP24 affects Aneuploidy
| 2
USP24 inhibits Aneuploidy. 2 / 2
| 2
eidos
"We have found that reduced expression of USP24 leads to abnormalities in the mitotic spindle and a significant increase in chromosome missegregation and aneuploidy in a mouse model ."
36338721
eidos
"USP24 prevented aneuploidy by maintaining spindle-associated CRMP2 , which is required for mitotic accuracy ."
33355202
RP2 affects USP24
2 |
RP2 binds USP24. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
RHOJ affects USP24
2 |
USP24 binds RHOJ. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
PTTG1 affects USP24
| 1 1
USP24 binds PTTG1. 2 / 2
| 1 1
reach
"Here we found that USP24 interacted with securin in mitotic cells (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
sparser
"Here we found that USP24 interacted with securin in mitotic cells ( xref ; xref )."
27991932
LYPD3 affects USP24
2 |
USP24 binds LYPD3. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
Ku-70 affects USP24
| 2
USP24 binds Ku-70. 2 / 2
| 2
sparser
"Previous studies indicated that Ku70 was involved in Bax mitochondrial translocation. xref Herein, we used a yeast two-hybrid assay to study the interaction between Ku70 and USP24 ( xref ; xref )."
27991932
sparser
"The data revealed that USP24 interacted with Ku70 ( xref )."
27991932
BAX affects USP24
| 1 1
USP24 binds BAX. 2 / 2
| 1 1
reach
"Next, we found that USP24 interacted with Bax (XREF_FIG D)."
27991932
sparser
"Next, we found that USP24 interacted with Bax ( xref D)."
27991932
Tungsten affects USP24
1 |
Tungsten decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
30912803
Troglitazone affects USP24
1 |
Troglitazone decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
28973697
Trichostatin A affects USP24
1 |
Trichostatin A increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
24935251
Topotecan affects USP24
1 |
Topotecan decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
25729387
Sunitinib affects USP24
1 |
Sunitinib increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
31533062
Sodium fluoride affects USP24
1 |
Sodium fluoride increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
27862939
Potassium chromate decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
22079256
Phlorizin affects USP24
1 |
Phlorizin decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
22538082
Patients tumors affects USP24
| 1
Patients tumors inhibits USP24. 1 / 1
| 1
eidos
"We further found that patients whose tumors had reduced expression of USP24 , defined as less than the 20th percentile , were significantly more likely to suffer disease progression and to die of any cause ."
36338721
Paracetamol affects USP24
1 |
Paracetamol decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
21420995
Oxaliplatin affects USP24
1 |
Oxaliplatin decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
25729387
Orf10 affects TP53
| 1
TP53 binds USP24 and orf10. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
Nickel atom affects USP24
1 |
Nickel atom increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
25583101
Mono(2-ethylhexyl) phthalate decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
31059758
Modified WP1130 affects USP24
| 1
Modified WP1130 inhibits USP24. 1 / 1
| 1
eidos
"Dose-dependent inhibition of USP9X and USP24 activity by a modified compound of WP1130 , EOAI3402143 , increased cell apoptosis and completely regressed myeloma tumors in mice models [ 127 ] ."
32354135
MiR-363 affects USP24
| 1
MiR-363 activates USP24. 1 / 1
| 1
reach
"It is noteworthy that miR-25 targeting BMPR2 and IRS1, miR-363 targeting USP24, miR-28 targeting HECW2 and miR-210 targeting ATP5I, ME3, MTCH1 and CPT2 were highly associated with slow-twitch oxidative fibers, fast-twitch oxidative fibers, ADP and ATP concentration suggesting an essential role of the miRNA mRNA regulatory networking in modulating the mitochondrial energy expenditure in the porcine muscle."
27485725
MiR-139-5p affects USP24
| 1
MiR-139-5p activates USP24. 1 / 1
| 1
reach
"On the contrary, the expression of USP24 in pDCs was significantly inversely correlated with miR-139-5p levels in both discovery cohort I and II (XREF_FIG C), corroborating that miR-139-5p targets the USP24 gene and protein expression, both in vitro and ex vivo in pDCs from SSc patients."
33573268
Methylmercury chloride decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
23103053
Methapyrilene affects USP24
1 |
Methapyrilene decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
30467583
Jinfukang affects USP24
1 |
Jinfukang decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
27392435
Irinotecan affects USP24
1 |
Irinotecan decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
18927307
Indometacin affects USP24
1 |
Indometacin decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
28628672
Hsa-miR-935 affects USP24
1 |
Hsa-miR-935 decreases the amount of USP24. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-196a-5p affects USP24
1 |
Hsa-miR-196a-5p decreases the amount of USP24. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-193b-3p affects USP24
1 |
Hsa-miR-193b-3p decreases the amount of USP24. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-181b-5p affects USP24
1 |
Hsa-miR-181b-5p decreases the amount of USP24. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-1226-3p affects USP24
1 |
Hsa-miR-1226-3p decreases the amount of USP24. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-let-7d-5p affects USP24
1 |
Hsa-let-7d-5p decreases the amount of USP24. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Gentamycin affects USP24
1 |
Gentamycin increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
22061828
Gefitinib affects USP24
| 1
Gefitinib increases the amount of USP24. 1 / 1
| 1
reach
"Gefitinib and FTI-276, which inhibited the EGFR and Kras activities 21 in the A431 and A549 cell lines, respectively, increased USP24 expression (XREF_FIG)."
27991932
GB affects USP24
1 |
USP24 binds gB. 1 / 1
1 |
virhostnet
No evidence text available
31873071
Ethyl methanesulfonate decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
23649840
Ethanol affects USP24
1 |
Ethanol decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
29018328
Dexamethasone affects USP24
1 |
Dexamethasone decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
28628672
Deoxynivalenol affects USP24
1 |
Deoxynivalenol phosphorylates USP24. 1 / 1
1 |
ctd
No evidence text available
23811945
Degrasyn affects USP24
| 1
Degrasyn inhibits USP24. 1 / 1
| 1
eidos
"Peterson and colleagues suggested that dual inhibition of USP9X and USP24 by WP1130 provides greater anti-myeloma activity ."
32354135
Cyclosporin A affects USP24
1 |
Cyclosporin A increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
20106945
Certain affects USP24
| 1
Certain activates USP24. 1 / 1
| 1
eidos
"Therefore , upregulation of USP2-4 by certain stimuli may alter the contraction of cardiac muscle ."
33530560
Cefaloridine affects USP24
1 |
Cefaloridine decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
18500788
Butanal affects USP24
1 |
Butanal decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
26079696
Bisphenol F affects USP24
1 |
Bisphenol F decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
28628672
Auramine O affects USP24
1 |
Auramine O increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
28722353
Atrazine affects USP24
1 |
Atrazine decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
25929836
Aldosterone affects USP24
| 1
Aldosterone activates USP24. 1 / 1
| 1
eidos
"Given that USP2-4 is strikingly induced by aldosterone [ 17 ] , the induction of USP2-4 may therefore function as a node of the negative feedback loop for MR signaling ."
33530560
Aflatoxin B1 affects USP24
1 |
Aflatoxin B1 increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
19770486
Acetamide affects USP24
1 |
Acetamide decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
31881176
Zoledronic Acid affects USP24
1 |
Zoledronic Acid decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
20977926
WWP2 affects USP24
1 |
USP24 binds WWP2. 1 / 1
1 |
biogrid
No evidence text available
25071155
VIPR2 affects USP24
1 |
USP24 binds VIPR2. 1 / 1
1 |
biogrid
No evidence text available
28514442
Ubiquitin affects USP24
| 1
Protease binds Ubiquitin and USP24. 1 / 1
| 1
sparser
"We conducted a case-control study in a cohort of 517 PD cases and 518 ethnically matched controls to investigate the association of ubiquitin specific proteases USP24 rs487230 C>T, USP40 rs1048603 C>T, and ubiquitin thiolesterase UCHL1 rs5030732 A>C polymorphisms with the risk of PD."
20302855
USP9X affects NOTCH1
| 1
USP24 binds USP9X and NOTCH1. 1 / 1
| 1
sparser
"Indeed, our pull-down studies for NOTCH1, followed by detection of USP24 and USP9x in western blot experiments, showed that neither USP9x nor USP24 interact with NOTCH1 ( xref )."
30224337
USP24-7656C affects USP24
| 1
USP24-7656C activates USP24. 1 / 1
| 1
reach
"USP24-930T and USP24-7656C increase USP24 expression levels by increasing RNA stability."
26568301
USP24 affects whole-chromosome aneuploidy
| 1
USP24 inhibits whole-chromosome aneuploidy. 1 / 1
| 1
eidos
"At the molecular level , USP24 loss leads to destabilization of the microtubule assembly factor CRMP2 - producing mitotic errors and leading to chromosome missegregation and whole-chromosome aneuploidy ."
36338721
USP24 affects ubiquitination subsequent beta-TrCP
| 1
USP24 inhibits ubiquitination subsequent beta-TrCP. 1 / 1
| 1
eidos
"USP24 also inhibits the ubiquitination and subsequent degradation of beta-TrCP , which polyubiquitinates IkappaB and upregulates NF-kappaB , resulting in increased IL-6 expression ."
33466790
USP24 affects ubiquitination RUNX2
| 1
USP24 inhibits ubiquitination RUNX2. 1 / 1
| 1
eidos
"However , unlike HAUSP , USP24 was unable to interact with RUNX2 and reduce ubiquitination levels of RUNX2 ( Supplementary Fig.12 ) , suggesting that HAUSP , not USP24 , functions as a bona-fide RUNX2-DUB ."
32385263
USP24 affects surface abundance ENaC
| 1
USP24 activates surface abundance ENaC. 1 / 1
| 1
eidos
"In support of this , another report also demonstrated that USP2-4 increased the surface abundance of ENaC by interfering with endocytosis , but not digestion , at the lysosome [ 96 ] ."
33530560
USP24 affects surface Cav1.2
| 1
USP24 inhibits surface Cav1.2. 1 / 1
| 1
eidos
"An overexpression study using kidney cells demonstrated that USP2-4 decreased the surface expression of Cav1.2 and attenuated Cav currents by suppression of ubiquitination of Cav1.2 and alpha2delta-1 subunits [ 135 ] ."
33530560
USP24 affects surface Ca attenuated Ca currents ubiquitination alpha2delta-1
| 1
USP24 inhibits surface Ca attenuated Ca currents ubiquitination alpha2delta-1. 1 / 1
| 1
eidos
"An overexpression study using kidney cells demonstrated that USP2-4 decreased the surface expression of Ca v 1.2 and attenuated Ca v currents by suppression of ubiquitination of Cav1.2 and alpha2delta-1 subunits [ 135 ] ."
33530560
USP24 affects stability GSDMB protein bladder cancer
| 1
USP24 activates stability GSDMB protein bladder cancer. 1 / 1
| 1
eidos
"These data suggest that USP24 promoted the stability of the GSDMB protein in bladder cancer by deubiquitinating GSDMB ."
34326684
USP24 affects sodium distribution body
| 1
USP24 activates sodium distribution body. 1 / 1
| 1
eidos
"The significant regulatory roles of USP2 on ENaC and MR expression suggest that USP2-4 is a key modulator for sodium distribution in the body , and therefore for blood pressure ."
33530560
USP24 affects proteolytic cleavage extracellular loop alphaENaC
| 1
USP24 activates proteolytic cleavage extracellular loop alphaENaC. 1 / 1
| 1
eidos
"Additionally , USP2-4 also contributed to the proteolytic cleavage of the extracellular loop of alphaENaC , leading to ENaC activation [ 95,97 ] ."
33530560
USP24 affects protein stability kinase ULK1
| 1
USP24 inhibits protein stability kinase ULK1. 1 / 1
| 1
eidos
"Downregulation of USP24 also enhances ULK1 ubiquitination , thereby increasing protein stability and kinase activity of ULK1 [ 230 ] ."
| PMC
USP24 affects protein beta-TrCP p300
| 1
USP24 activates protein beta-TrCP p300. 1 / 1
| 1
eidos
"Up-regulated USP24 increased the protein level of beta-TrCP and p300 to promote lung cancer malignancy 31 ."
34326684
USP24 affects process
| 1
USP24 activates process. 1 / 1
| 1
eidos
"We further showed that USP24 inhibitors could block this process via inducing GSDMB degradation in cancer cells , which provided a therapeutic strategy for inhibiting the GSDMB / STAT3 axis in bladder cancer ."
34326684
USP24 affects mouse model
| 1
USP24 inhibits mouse model. 1 / 1
| 1
eidos
"We have found that reduced expression of USP24 leads to abnormalities in the mitotic spindle and a significant increase in chromosome missegregation and aneuploidy in a mouse model ."
36338721
USP24 affects metastasis breast cancer
| 1
USP24 activates metastasis breast cancer. 1 / 1
| 1
eidos
"USP24 also enhances TGFbeta-induced EMT and metastasis of breast cancer [ 61 ] ."
31133011
USP24 affects lysosomal
| 1
USP24 inhibits lysosomal. 1 / 1
| 1
reach
"Blocking lysosomal function with bafilomycin led to significant increase in accumulation of GFP-LC3 positive autophagosomes in USP24 knockdown cells, indicating that USP24 is negatively regulating autophagy flux without affecting lysosomal degradation)."
30957634
USP24 affects localization
| 1
USP24 activates localization. 1 / 1
| 1
reach
"The localization of Bax in cells expressing GFP-USP24 indicated that USP24 expression increased Bax 's mitochondrial localization, implying that USP24 induced cell apoptosis (XREF_FIG)."
27991932
USP24 affects lipoprotein LDL uptake
| 1
USP24 inhibits lipoprotein LDL uptake. 1 / 1
| 1
eidos
"In the liver , USP2-4 promotes gluconeogenesis and increases low density lipoprotein ( LDL ) uptake by upregulating the LDL receptor ."
33530560
USP24 affects gluconeogenesis
| 1
USP24 activates gluconeogenesis. 1 / 1
| 1
eidos
"In the liver , USP2-4 promotes gluconeogenesis and increases low density lipoprotein ( LDL ) uptake by upregulating the LDL receptor ."
33530560
USP24 affects gB
1 |
USP24 binds gB. 1 / 1
1 |
virhostnet
No evidence text available
31873071
USP24 affects formation
| 1
USP24 inhibits formation. 1 / 1
| 1
sparser
"To investigate the molecular mechanism by which USP24 inhibited lung cancer formation, H1299 cells with GFP-USP24 or GFP expression were recorded using time-lapse microscopy ( xref ; xref )."
27991932
USP24 affects ferritin
| 1
USP24 activates ferritin. 1 / 1
| 1
reach
"pUL38 blocked USP24 mediated ferritin degradation in lysosomes, which could otherwise be detrimental to the lysosome and initiate cell death."
29695420
USP24 affects deubiquitination GSDMB
| 1
USP24 activates deubiquitination GSDMB. 1 / 1
| 1
eidos
"Thus , USP24 may mediate the deubiquitination of GSDMB and maintain its stability ."
34326684
USP24 affects circadian rhythm calcium permeability
| 1
USP24 activates circadian rhythm calcium permeability. 1 / 1
| 1
eidos
"Together , these results suggest that USP2-4 modulates the circadian rhythm of calcium permeability in the intestine via posttranslational control of NHERF4 at the plasma membrane ."
33530560
USP24 affects chromosome
| 1
USP24 inhibits chromosome. 1 / 1
| 1
eidos
"At the molecular level , USP24 loss leads to destabilization of the microtubule assembly factor CRMP2 - producing mitotic errors and leading to chromosome missegregation and whole-chromosome aneuploidy ."
36338721
USP24 affects chromosome missegregation
| 1
USP24 inhibits chromosome missegregation. 1 / 1
| 1
eidos
"We have found that reduced expression of USP24 leads to abnormalities in the mitotic spindle and a significant increase in chromosome missegregation and aneuploidy in a mouse model ."
36338721
USP24 affects cancer malignancy
| 1
USP24 activates cancer malignancy. 1 / 1
| 1
eidos
"Studies have also demonstrated that USP24 promotes cancer malignancy by inducing IL-6 transcription into tumor-infiltrating leukocytes , vascular endothelial cells , and cancer-associated fibroblasts [ 142 ] ."
32354135
USP24 affects assembly CRMP2
| 1
USP24 activates assembly CRMP2. 1 / 1
| 1
eidos
"At the molecular level , USP24 loss leads to destabilization of the microtubule assembly factor CRMP2 - producing mitotic errors and leading to chromosome missegregation and whole-chromosome aneuploidy ."
36338721
USP24 affects activation Toll IL-1R domain-containing adaptor
| 1
USP24 inhibits activation Toll IL-1R domain-containing adaptor. 1 / 1
| 1
eidos
"In addition , USP2-4 also inhibited the activation of the Toll / IL-1R domain-containing adaptor , which induces IFN-beta ( TRIF ) and cyclic GMP-AMP synthase ( cGAS ) / stimulator of interferon genes ( STING ) signaling , and attenuates IFNB1 ( encoding IFN-beta ) expression [ 155 ] ."
33530560
USP24 affects abnormalities mitotic spindle
| 1
USP24 inhibits abnormalities mitotic spindle. 1 / 1
| 1
eidos
"We have found that reduced expression of USP24 leads to abnormalities in the mitotic spindle and a significant increase in chromosome missegregation and aneuploidy in a mouse model ."
36338721
USP24 affects WWP2
1 |
USP24 binds WWP2. 1 / 1
1 |
biogrid
No evidence text available
25071155
USP24 affects VIPR2
1 |
USP24 binds VIPR2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP24 affects VEGF
| 1
USP24 increases the amount of VEGF. 1 / 1
| 1
reach
"The data indicated that the knockdown of USP24 in M2 macrophages decreased Angiopoirtin-2, CD40L, IL-6, tumor necrosis factor alpha (TNF-alpha), Thrombospondin-1 and vascular endothelial growth factor (VEGF) levels, indicating that USP24 is involved in angiogenesis."
30266897
USP24 affects Ubiquitin
| 1
Protease binds Ubiquitin and USP24. 1 / 1
| 1
sparser
"We conducted a case-control study in a cohort of 517 PD cases and 518 ethnically matched controls to investigate the association of ubiquitin specific proteases USP24 rs487230 C>T, USP40 rs1048603 C>T, and ubiquitin thiolesterase UCHL1 rs5030732 A>C polymorphisms with the risk of PD."
20302855
USP24 affects USP24-7656C
| 1
USP24 activates USP24-7656C. 1 / 1
| 1
reach
"USP24-930T and USP24-7656C increase USP24 expression levels by increasing RNA stability."
26568301
USP24 affects US7
1 |
USP24 binds US7. 1 / 1
1 |
virhostnet
No evidence text available
31873071
USP24 affects ULK1 ubiquitination
| 1
USP24 inhibits ULK1 ubiquitination. 1 / 1
| 1
eidos
"Downregulation of USP24 also enhances ULK1 ubiquitination , thereby increasing protein stability and kinase activity of ULK1 [ 230 ] ."
| PMC
USP24 affects UL9
1 |
USP24 binds UL9. 1 / 1
1 |
virhostnet
No evidence text available
31873071
USP24 affects UL38
1 |
USP24 binds UL38. 1 / 1
1 |
virhostnet
No evidence text available
31873071
USP24 affects UL29
1 |
USP24 binds UL29. 1 / 1
1 |
virhostnet
No evidence text available
31873071
USP24 affects UL135
1 |
USP24 binds UL135. 1 / 1
1 |
virhostnet
No evidence text available
31873071
USP24 affects UBC
1 |
UBC binds USP24. 1 / 1
1 |
biogrid
No evidence text available
28190767
USP24 affects TRIM25
1 |
USP24 binds TRIM25. 1 / 1
1 |
biogrid
No evidence text available
29117863
USP24 affects SeV-elicited TBK1
| 1
USP24 inhibits SeV-elicited TBK1. 1 / 1
| 1
eidos
"Furthermore , USP2-4 repressed SeV-elicited TBK1 activation [ 155 ] , suggesting that TBK1 is a direct target of USP2-4 ."
33530560
USP24 affects SYMPK
1 |
USP24 binds SYMPK. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP24 affects STAT3 signaling
| 1
USP24 activates STAT3 signaling. 1 / 1
| 1
eidos
"Besides , we also showed that USP24 stabilized GSDMB to activate STAT3 signaling , which was blocked by the USP24 inhibitor ."
34326684
USP24 affects STAT3 pathway bladder cancer cells
| 1
USP24 activates STAT3 pathway bladder cancer cells. 1 / 1
| 1
eidos
"Here , our results indicated that USP24 bound to GSDMB to stabilize GSDMB , and subsequently activated the STAT3 pathway in bladder cancer cells ."
34326684
USP24 affects SOX2
1 |
SOX2 binds USP24. 1 / 1
1 |
biogrid
No evidence text available
23667531
USP24 affects SMARCA4
| 1
SMARCA4 binds USP24 and BRD7. 1 / 1
| 1
sparser
"Next, when HA-BRD7 and HA-BRG1 were expressed in H1299 cells or MEFs, we found that USP24 interacted with BRD7 and BRG1, indicating that USP24 could interact with more than one BRD-containing protein in different cell lines (Fig.  xref B,C and Suppl."
33257797
USP24 affects SLC33A1
1 |
USP24 binds SLC33A1. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP24 affects SIRT7
1 |
USP24 binds SIRT7. 1 / 1
1 |
biogrid
No evidence text available
22586326
USP24 affects RP23-333D2.2
1 |
USP24 binds RP23-333D2.2. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP24 affects Q20MH8
1 |
USP24 binds Q20MH8. 1 / 1
1 |
virhostnet
No evidence text available
26651948
USP24 affects PtdIns3P
| 1
USP24 inhibits PtdIns3P. 1 / 1
| 1
reach
"These data suggest that USP24 knockdown stimulates PtdIns3P production."
30957634
USP24 affects Protease
| 1
Protease binds Ubiquitin and USP24. 1 / 1
| 1
sparser
"We conducted a case-control study in a cohort of 517 PD cases and 518 ethnically matched controls to investigate the association of ubiquitin specific proteases USP24 rs487230 C>T, USP40 rs1048603 C>T, and ubiquitin thiolesterase UCHL1 rs5030732 A>C polymorphisms with the risk of PD."
20302855
USP24 affects PI3K
| 1
USP24 activates PI3K. 1 / 1
| 1
reach
"In addition, we found that USP24 phosphorylation at Ser2604 was declined by U0126, which inhibited the Erk1/2 activities in A549 cells (XREF_FIG); however, USP24 phosphorylation was not decreased by LY294002, which inhibited the PI3K activities (XREF_SUPPLEMENTARY)."
27991932
USP24 affects ORF10
1 |
USP24 binds ORF10. 1 / 1
1 |
virhostnet
No evidence text available
25544563
USP24 affects ORF
| 1
TP53 binds USP24 and ORF. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
USP24 affects Numbl
| 1
USP24 binds Numbl. 1 / 1
| 1
sparser
"The association of USP24 reduction and aggressive NBL is seemingly at odds with the general association between numerical chromosome instability and favorable disease outcomes."
36338721
USP24 affects NOTCH1
| 1
USP24 binds USP9X and NOTCH1. 1 / 1
| 1
sparser
"Indeed, our pull-down studies for NOTCH1, followed by detection of USP24 and USP9x in western blot experiments, showed that neither USP9x nor USP24 interact with NOTCH1 ( xref )."
30224337
USP24 affects NFkappaB pathway
| 1
USP24 activates NFkappaB pathway. 1 / 1
| 1
eidos
"Our recent study also indicated that USP24 can induce the NFkappaB pathway by stabilizing the betaTrCP , which is the E3-ligase of IkappaB and DNMT1 , causing the degradation of IkappaB and DNMT1 [ 75 ] ."
31133011
USP24 affects NCS1
1 |
USP24 binds NCS1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP24 affects NCOA4
| 1
USP24 inhibits NCOA4. 1 / 1
| 1
reach
"Knockdown of USP24 decreased NCOA4 protein stability and ferritin heavy chain degradation in lysosomes."
29695420
USP24 affects MYH6
1 |
USP24 binds MYH6. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP24 affects MTHFR
| 1
USP24 binds EPS15 and MTHFR. 1 / 1
| 1
sparser
"Only three of these genes, USP24 , MTHFR , and EPS15 , have been associated with PD in earlier studies ( xref xref xref )."
26785691
USP24 affects MDM2 well-known E3 ligase P53 lung cancer
| 1
USP24 activates MDM2 well-known E3 ligase P53 lung cancer. 1 / 1
| 1
eidos
"Intriguingly , USP24 up-regulates the expression of MDM2 , the well-known E3 ligase of P53 , in lung cancer , which contradicts the above finding 31 ."
34326684
USP24 affects MCP
1 |
USP24 binds MCP. 1 / 1
1 |
virhostnet
No evidence text available
31873071
USP24 affects KRAS
| 1
USP24 inhibits KRAS-G12D. 1 / 1
| 1
reach
"12 In this study, we found that the modification of USP24 by phosphorylation decreased its protein stability in Kras G12D - and EDFR L858R -induced lung cancer mouse models, lung cancer cell lines and mitotic cells."
27991932
USP24 affects JUNB
1 |
USP24 binds JUNB. 1 / 1
1 |
biogrid
No evidence text available
20195357
USP24 affects Infections
| 1
USP24 activates Infections. 1 / 1
| 1
reach
"As a consequence, USP24 knockdown dramatically inhibited EV71 infection."
36334706
USP24 affects IL24
| 1
USP24 increases the amount of IL24. 1 / 1
| 1
reach
"USP24 positively regulates IL-6, IL-8, IL-22, and IL-24 expression but negatively regulates IL-10 and IL-17 expression."
30266897
USP24 affects IL17A
| 1
USP24 decreases the amount of IL17A. 1 / 1
| 1
reach
"USP24 positively regulates IL-6, IL-8, IL-22, and IL-24 expression but negatively regulates IL-10 and IL-17 expression."
30266897
USP24 affects IL10
| 1
USP24 decreases the amount of IL10. 1 / 1
| 1
reach
"USP24 positively regulates IL-6, IL-8, IL-22, and IL-24 expression but negatively regulates IL-10 and IL-17 expression."
30266897
USP24 affects Histone_H3
| 1
USP24 leads to the acetylation of Histone_H3. 1 / 1
| 1
reach
"It has been described that the cysteine protease USP24 stabilizes p300 and thereby increases acetylation of histone h3 (Wang et al. 2018)."
31951590
USP24 affects HNRNPD
1 |
USP24 binds HNRNPD. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP24 affects HIF1AN
1 |
USP24 binds HIF1AN. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP24 affects HHV8GK18_gp07
1 |
USP24 binds HHV8GK18_gp07. 1 / 1
1 |
biogrid
No evidence text available
25544563
USP24 affects GSDMB protein
| 1
USP24 activates GSDMB protein. 1 / 1
| 1
eidos
"USP24 stabilizes GSDMB to promote STAT3 phosphorylation in bladder cancer cells Given that USP24 promoted the expression of the GSDMB protein levels rather than that of the mRNA levels in bladder cancer cells , we hypothesized that USP24 may regulate the stability of GSDMB through the ubiquitinated proteasome pathway ."
34326684
USP24 affects FTH1
| 1
USP24 activates FTH1. 1 / 1
| 1
reach
"Knockdown of USP24 decreased NCOA4 protein stability and ferritin heavy chain degradation in lysosomes."
29695420
USP24 affects FOXK1
1 |
USP24 binds FOXK1. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP24 affects EZR
| 1
USP24 activates EZR. 1 / 1
| 1
reach
"Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness, but also increased the levels of the ATP binding cassette (ABC) transporters P-gp, ABCG2, and ezrin to enhance the pumping out of Taxol from cancer cells, thus resulted in drug resistance during cancer therapy."
33846536
USP24 affects EV71
| 1
USP24 activates EV71. 1 / 1
| 1
reach
"As a consequence, USP24 knockdown dramatically inhibited EV71 infection."
36334706
USP24 affects EPS15
| 1
USP24 binds EPS15 and MTHFR. 1 / 1
| 1
sparser
"Only three of these genes, USP24 , MTHFR , and EPS15 , have been associated with PD in earlier studies ( xref xref xref )."
26785691
USP24 affects E2F1
| 1
USP24 increases the amount of E2F1. 1 / 1
| 1
reach
"Knockdown of USP24 increased the CCNA2 and E2F1 mRNA levels (XREF_FIG); the same results were obtained in the cDNA array performed under USP24 knockdown conditions (XREF_SUPPLEMENTARY)."
27991932
USP24 affects Drug Resistance
| 1
USP24 activates Drug Resistance. 1 / 1
| 1
eidos
"USP24 promotes drug resistance during cancer therapy ."
33846536
USP24 affects DNA-damage repair DDR
| 1
USP24 inhibits DNA-damage repair DDR. 1 / 1
| 1
eidos
"Herein , we found that USP24 not only repressed DNA-damage repair ( DDR ) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness , but also increased the levels of the ATP-binding cassette ( ABC ) transporters P-gp , ABCG2 , and ezrin to enhance the pumping out of Taxol from cancer cells , thus resulted in drug resistance during cancer therapy ."
33846536
USP24 inhibits DNA damage response, detection of DNA damage. 1 / 1
| 1
reach
"Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness, but also increased the levels of the ATP binding cassette (ABC) transporters P-gp, ABCG2, and ezrin to enhance the pumping out of Taxol from cancer cells, thus resulted in drug resistance during cancer therapy."
33846536
USP24 affects Cell Survival
| 1
reach
"Finally, USP24 knockdown increased the cell numbers and cell viability in A549 and lung primary cells, suggesting that USP24 negatively regulated lung cancer formation (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 affects Cav currents
| 1
USP24 inhibits Cav currents. 1 / 1
| 1
eidos
"An overexpression study using kidney cells demonstrated that USP2-4 decreased the surface expression of Cav1.2 and attenuated Cav currents by suppression of ubiquitination of Cav1.2 and alpha2delta-1 subunits [ 135 ] ."
33530560
USP24 affects CSNK2A1
1 |
USP24 binds CSNK2A1. 1 / 1
1 |
biogrid
No evidence text available
22113938
reach
"USP24 was reactivated using the deactivated CRISPR associated protein 9 (dCas9)-synergistic activation mediator (SAM) system."
30911287
USP24 affects CPNE2
1 |
USP24 binds CPNE2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP24 affects COPS7B
1 |
USP24 binds COPS7B. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP24 affects CNOT2
1 |
USP24 binds CNOT2. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP24 affects CK2
| 1
CK2 binds USP24. 1 / 1
| 1
reach
"To examine endogenous interaction between RUNX2 and CK2 or USP24, cell lysates were obtained from mouse COBs and prepared in lysis buffer (50mM Tris-HCl (pH 7.4), 150mM NaCl, 1% Triton X-100, 1mM EDTA, 1mM EGTA, 50mM NaF, 1mM Na 3 VO 4, 1mM PMSF, and protease inhibitor cocktail (Sigma))."
32385263
USP24 affects CHRM4
1 |
USP24 binds CHRM4. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP24 affects CDC5L
1 |
USP24 binds CDC5L. 1 / 1
1 |
biogrid
No evidence text available
20467437
USP24 affects CCL2
| 1
USP24 increases the amount of CCL2. 1 / 1
| 1
reach
"However, in this study, USP24 activated NF-kappaB did not increase CCL2, implying that other factors regulated by USP24 might negatively regulate CCL2 expression."
30266897
USP24 affects CASP3
| 1
USP24 decreases the amount of CASP3. 1 / 1
| 1
reach
"Knockdown of USP24 decreased the Bax and caspase-3 levels; conversely, these protein levels were increased in GFP-USP24-expressing cells, although no alterations were observed in the Bax mRNA level (XREF_FIG; XREF_SUPPLEMENTARY)."
27991932
USP24 affects BMX
1 |
BMX binds USP24. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP24 affects BH3
| 1
USP24 deubiquitinates BH3. 1 / 1
| 1
reach
"In agreement with previous reports indicating that USP24 may de-ubiquitinate the pro apoptotic BH3 protein BAX [31], we also observed a decrease in BAX protein levels in USP24 knockdown cells)."
30957634
USP24 affects BBC3
| 1
USP24 inhibits BBC3. 1 / 1
| 1
reach
"USP24 depletion inhibits PUMA activation and PARP cleavage in response to UV damage."
25578727
USP24 affects ATP-binding cassette
| 1
USP24 activates ATP-binding cassette. 1 / 1
| 1
eidos
"Herein , we found that USP24 not only repressed DNA-damage repair ( DDR ) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness , but also increased the levels of the ATP-binding cassette ( ABC ) transporters P-gp , ABCG2 , and ezrin to enhance the pumping out of Taxol from cancer cells , thus resulted in drug resistance during cancer therapy ."
33846536
USP24 affects ARRB1
1 |
USP24 binds ARRB1. 1 / 1
1 |
biogrid
No evidence text available
17620599
USP24 affects APC_C
| 1
APC_C binds USP24. 1 / 1
| 1
sparser
"Several phosphorylation residues in USP24 are involved in the control of protein stability by increasing the interaction between USP24 and the APC/C complex, suggesting that APC/C might be important for the downregulation of USP24."
27991932
USP24 affects ABCG2
| 1
USP24 activates ABCG2. 1 / 1
| 1
reach
"Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness, but also increased the levels of the ATP binding cassette (ABC) transporters P-gp, ABCG2, and ezrin to enhance the pumping out of Taxol from cancer cells, thus resulted in drug resistance during cancer therapy."
33846536
USP24 be compensated affects USP24
| 1
USP24 be compensated activates USP24. 1 / 1
| 1
eidos
"Both sets of experiments demonstrated that USP24 expression was abolished and that U2OS cells deleted for USP24 are viable , most likely because loss of USP24 can be compensated for by cellular reprogramming or the presence of other , compensating USPs in the cell ."
33411764
US7 affects USP24
1 |
USP24 binds US7. 1 / 1
1 |
virhostnet
No evidence text available
31873071
UL9 affects USP24
1 |
USP24 binds UL9. 1 / 1
1 |
virhostnet
No evidence text available
31873071
UL38 affects USP24
1 |
USP24 binds UL38. 1 / 1
1 |
virhostnet
No evidence text available
31873071
UL29 affects USP24
1 |
USP24 binds UL29. 1 / 1
1 |
virhostnet
No evidence text available
31873071
UL135 affects USP24
1 |
USP24 binds UL135. 1 / 1
1 |
virhostnet
No evidence text available
31873071
UBC affects USP24
1 |
UBC binds USP24. 1 / 1
1 |
biogrid
No evidence text available
28190767
TRIM25 affects USP24
1 |
USP24 binds TRIM25. 1 / 1
1 |
biogrid
No evidence text available
29117863
TP53 affects orf10
| 1
TP53 binds USP24 and orf10. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
TP53 affects ORF
| 1
TP53 binds USP24 and ORF. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
TLR9 affects USP24
| 1
TLR9 increases the amount of USP24. 1 / 1
| 1
reach
"The expression level of USP24 was inversely correlated with miR-139-5p expression in SSc patients and induced by TLR9 stimulation in healthy pDCs."
33573268
TBK1 affects USP24
| 1
TBK1 binds USP24. 1 / 1
| 1
sparser
"Further studies revealed that USP24 physically interacted with TBK1, and can reduce K63-linked polyubiquitination of TBK1."
36334706
T-2 Toxin affects USP24
1 |
T-2 Toxin decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
31299295
SYMPK affects USP24
1 |
USP24 binds SYMPK. 1 / 1
1 |
biogrid
No evidence text available
26344197
SUV39H1 affects USP24
1 |
SUV39H1 binds USP24. 1 / 1
1 |
biogrid
No evidence text available
28514442
SOX2 affects USP24
1 |
SOX2 binds USP24. 1 / 1
1 |
biogrid
No evidence text available
23667531
SMARCA4 affects USP24
| 1
SMARCA4 binds USP24 and BRD7. 1 / 1
| 1
sparser
"Next, when HA-BRD7 and HA-BRG1 were expressed in H1299 cells or MEFs, we found that USP24 interacted with BRD7 and BRG1, indicating that USP24 could interact with more than one BRD-containing protein in different cell lines (Fig.  xref B,C and Suppl."
33257797
SLC33A1 affects USP24
1 |
USP24 binds SLC33A1. 1 / 1
1 |
biogrid
No evidence text available
26496610
SIRT7 affects USP24
1 |
USP24 binds SIRT7. 1 / 1
1 |
biogrid
No evidence text available
22586326
RUNX2 affects USP24
| 1
RUNX2 binds USP24. 1 / 1
| 1
reach
"To examine endogenous interaction between RUNX2 and CK2 or USP24, cell lysates were obtained from mouse COBs and prepared in lysis buffer (50mM Tris-HCl (pH 7.4), 150mM NaCl, 1% Triton X-100, 1mM EDTA, 1mM EGTA, 50mM NaF, 1mM Na 3 VO 4, 1mM PMSF, and protease inhibitor cocktail (Sigma))."
32385263
RP23-333D2.2 affects USP24
1 |
USP24 binds RP23-333D2.2. 1 / 1
1 |
biogrid
No evidence text available
26496610
Q20MH8 affects USP24
1 |
USP24 binds Q20MH8. 1 / 1
1 |
virhostnet
No evidence text available
26651948
Protease affects Ubiquitin
| 1
Protease binds Ubiquitin and USP24. 1 / 1
| 1
sparser
"We conducted a case-control study in a cohort of 517 PD cases and 518 ethnically matched controls to investigate the association of ubiquitin specific proteases USP24 rs487230 C>T, USP40 rs1048603 C>T, and ubiquitin thiolesterase UCHL1 rs5030732 A>C polymorphisms with the risk of PD."
20302855
Plant Extracts affects USP24
1 |
Plant Extracts increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
23557933
Parkinson Disease affects USP24
| 1
Parkinson Disease increases the amount of USP24. 1 / 1
| 1
reach
"Thus, PD associated USP24 SNPs could similarly increase USP24 expression, leading to lowering of autophagy flux."
30957634
PDC affects USP24
| 1
PDC activates USP24. 1 / 1
| 1
eidos
"The expression level of USP24 was inversely correlated with miR-139-5p expression in SSc patients and induced by TLR9 stimulation in healthy pDCs ."
33573268
Other factor(s) affects USP24
| 1
Other factor(s) activates USP24. 1 / 1
| 1
reach
"Other factor (s) in addition to the EGFR activated pathway may be involved in the regulation of USP24 during tumorigenesis."
27991932
ORF affects USP24
| 1
TP53 binds USP24 and ORF. 1 / 1
| 1
sparser
"This third, independent assay format thus supports a direct interaction between USP24, p53 and orf10."
33411764
Numbl affects USP24
| 1
USP24 binds Numbl. 1 / 1
| 1
sparser
"The association of USP24 reduction and aggressive NBL is seemingly at odds with the general association between numerical chromosome instability and favorable disease outcomes."
36338721
Neoplasms affects USP24
| 1
Neoplasms decreases the amount of USP24. 1 / 1
| 1
reach
"We further found that patients whose tumors had reduced expression of USP24, defined as less than the 20 percentile, were significantly more likely to suffer disease progression and to die of any cause."
36338721
NOTCH1 affects USP9X
| 1
USP24 binds USP9X and NOTCH1. 1 / 1
| 1
sparser
"Indeed, our pull-down studies for NOTCH1, followed by detection of USP24 and USP9x in western blot experiments, showed that neither USP9x nor USP24 interact with NOTCH1 ( xref )."
30224337
NCS1 affects USP24
1 |
USP24 binds NCS1. 1 / 1
1 |
biogrid
No evidence text available
28514442
reach
"MG132 treatment rescued the USP24 level in the mitotic stage (XREF_SUPPLEMENTARY)."
27991932
MYH6 affects USP24
1 |
USP24 binds MYH6. 1 / 1
1 |
biogrid
No evidence text available
26496610
MTHFR affects USP24
| 1
USP24 binds EPS15 and MTHFR. 1 / 1
| 1
sparser
"Only three of these genes, USP24 , MTHFR , and EPS15 , have been associated with PD in earlier studies ( xref xref xref )."
26785691
MCP affects USP24
1 |
USP24 binds MCP. 1 / 1
1 |
virhostnet
No evidence text available
31873071
LY294002 affects USP24
| 1
LY294002 leads to the dephosphorylation of USP24. 1 / 1
| 1
reach
"In addition, we found that USP24 phosphorylation at Ser2604 was declined by U0126, which inhibited the Erk1/2 activities in A549 cells (XREF_FIG); however, USP24 phosphorylation was not decreased by LY294002, which inhibited the PI3K activities (XREF_SUPPLEMENTARY)."
27991932
LC3-II affects USP24
| 1
LC3-II inhibits USP24. 1 / 1
| 1
reach
"Accumulation of LC3-II following knockdown of USP24 was further enhanced by the treatment with lysosomal inhibitor chloroquine)."
30957634
Ketolides affects USP24
1 |
Ketolides increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
24967691
JUNB affects USP24
1 |
USP24 binds JUNB. 1 / 1
1 |
biogrid
No evidence text available
20195357
Hyperoxia affects USP24
1 |
Hyperoxia increases the amount of USP24. 1 / 1
1 |
bel
"the human airway early response to hyperoxia relies predominantly upon induction of cytoprotective chaperones and the ubiquitin-proteasome-dependent protein degradation system to maintain airway homeostatic integrity. Upregulated"
16690988
HNRNPD affects USP24
1 |
USP24 binds HNRNPD. 1 / 1
1 |
biogrid
No evidence text available
26496610
HIF1AN affects USP24
1 |
USP24 binds HIF1AN. 1 / 1
1 |
biogrid
No evidence text available
28514442
HHV8GK18_gp07 affects USP24
1 |
USP24 binds HHV8GK18_gp07. 1 / 1
1 |
biogrid
No evidence text available
25544563
FTI-276 affects USP24
| 1
FTI-276 increases the amount of USP24. 1 / 1
| 1
reach
"Gefitinib and FTI-276, which inhibited the EGFR and Kras activities 21 in the A431 and A549 cell lines, respectively, increased USP24 expression (XREF_FIG)."
27991932
FOXK1 affects USP24
1 |
USP24 binds FOXK1. 1 / 1
1 |
biogrid
No evidence text available
22863883
EPS15 affects USP24
| 1
USP24 binds EPS15 and MTHFR. 1 / 1
| 1
sparser
"Only three of these genes, USP24 , MTHFR , and EPS15 , have been associated with PD in earlier studies ( xref xref xref )."
26785691
E2F1 affects USP24
| 1
E2F1 inhibits USP24. 1 / 1
| 1
reach
"Overexpression of E2F4 in USP24 silenced cells rescued only the E2F1 mRNA level and partially abolished the effect of the USP24 knockdown on the G1-S transition and colony formation (XREF_FIG; XREF_SUPPLEMENTARY), implying that E2F4 might be involved in USP24 mediated cell cycle progression."
27991932
DNMT1 affects USP24
| 1
DNMT1 inhibits USP24. 1 / 1
| 1
reach
"Interestingly, the DNMT1 level was increased in A549 cells, but not in M2 macrophages, after USP24 knockdown by increased DNMT1 protein stability."
30266897
CSNK2A1 affects USP24
1 |
USP24 binds CSNK2A1. 1 / 1
1 |
biogrid
No evidence text available
22113938
CPNE2 affects USP24
1 |
USP24 binds CPNE2. 1 / 1
1 |
biogrid
No evidence text available
28514442
COPS7B affects USP24
1 |
USP24 binds COPS7B. 1 / 1
1 |
biogrid
No evidence text available
22863883
CNOT2 affects USP24
1 |
USP24 binds CNOT2. 1 / 1
1 |
biogrid
No evidence text available
26496610
CK2 affects USP24
| 1
CK2 binds USP24. 1 / 1
| 1
reach
"To examine endogenous interaction between RUNX2 and CK2 or USP24, cell lysates were obtained from mouse COBs and prepared in lysis buffer (50mM Tris-HCl (pH 7.4), 150mM NaCl, 1% Triton X-100, 1mM EDTA, 1mM EGTA, 50mM NaF, 1mM Na 3 VO 4, 1mM PMSF, and protease inhibitor cocktail (Sigma))."
32385263
CHRM4 affects USP24
1 |
USP24 binds CHRM4. 1 / 1
1 |
biogrid
No evidence text available
28514442
CDC5L affects USP24
1 |
USP24 binds CDC5L. 1 / 1
1 |
biogrid
No evidence text available
20467437
BRD7 affects SMARCA4, and USP24
| 1
SMARCA4 binds USP24 and BRD7. 1 / 1
| 1
sparser
"Next, when HA-BRD7 and HA-BRG1 were expressed in H1299 cells or MEFs, we found that USP24 interacted with BRD7 and BRG1, indicating that USP24 could interact with more than one BRD-containing protein in different cell lines (Fig.  xref B,C and Suppl."
33257797
BMX affects USP24
1 |
BMX binds USP24. 1 / 1
1 |
biogrid
No evidence text available
28514442
ARRB1 affects USP24
1 |
USP24 binds ARRB1. 1 / 1
1 |
biogrid
No evidence text available
17620599
APC_C affects USP24
| 1
APC_C binds USP24. 1 / 1
| 1
sparser
"Several phosphorylation residues in USP24 are involved in the control of protein stability by increasing the interaction between USP24 and the APC/C complex, suggesting that APC/C might be important for the downregulation of USP24."
27991932
3-isobutyl-1-methyl-7H-xanthine decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
28628672
2,6-dinitrotoluene increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
20406850
1-phenylpropan-2-amine decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
30779732
1-naphthyl isothiocyanate decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
30723492
1,2-dimethylhydrazine increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
27840820
(-)-epigallocatechin 3-gallate decreases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
22079256
ctd
No evidence text available
12756304
3,3',4,4',5-pentachlorobiphenyl increases the amount of USP24. 1 / 1
1 |
ctd
No evidence text available
28973690