IndraLab

Statements

USP21 affects NANOG
8 1 | 1
USP21 binds NANOG.
8 |
USP21 binds NANOG. 8 / 10
8 |
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27886188
USP21 deubiquitinates NANOG.
1 | 1
USP21 deubiquitinates NANOG. 2 / 2
1 | 1
reach
"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."
30891497
ubibrowser
"Review"
28279784
USP21 is modified
8 | 1 3
USP21 is phosphorylated.
6 | 3
USP21 is phosphorylated on S116. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19413330
USP21 is phosphorylated on T132. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19413330
USP21 is phosphorylated. 2 / 2
| 2
rlimsp
"p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation."
28254948
rlimsp
"Thus, our study reveals a critical role of p38-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses."
28254948
USP21 is phosphorylated on S140. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19413330
USP21 is phosphorylated on S538. 1 / 1
| 1
rlimsp
"HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation of USP21 at Ser538."
28254948
USP21 is acetylated.
2 |
USP21 is acetylated on S113. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19413330
USP21 is deubiquitinated.
| 1
USP21 is deubiquitinated. 1 / 1
| 1
trips
"Deubiquitinating enzyme USP21 inhibits HIV-1 replication by downregulating Tat expression."
33827943
NANOG affects USP21
8 |
USP21 binds NANOG. 8 / 10
8 |
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27886188
eidos
"Therefore , USP21 stimulates cell proliferation but cannot cause cell death ."
33389794
eidos
"We identify that knockdown of USP21 inhibits cell proliferation , and overexpression of USP21 promotes cell growth ."
33389794
eidos
"These data demonstrate that USP21 promotes cell proliferation via its deubiquitinating active site ."
33389794
eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
33791299
eidos
"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."
32784507
eidos
"USP21 promotes cell proliferation via Cys-221 ."
33389794
eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."
33791299
eidos
"USP21 knockdown or overexpression in the DLBCL cell line shows that USP21 promotes cell proliferation ."
33389794
eidos
"USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma MA et al. Abstract Background Diffuse large B-cell lymphoma ( DLBCL ) is the most common category of non-Hodgkin lymphoma ( NHL ) ."
33389794
USP21 affects UBC
8 |
UBC binds USP21. 8 / 8
8 |
biogrid
No evidence text available
25527291
biogrid
No evidence text available
21399617
biogrid
No evidence text available
20622874
biogrid
No evidence text available
21399617
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22298430
biogrid
No evidence text available
23287719
biogrid
No evidence text available
22195557
USP21 affects DDX58
3 1 | 1
USP21 binds DDX58.
3 |
USP21 binds DDX58. 3 / 4
3 |
biogrid
No evidence text available
24493797
biogrid
No evidence text available
24493797
biogrid
No evidence text available
24493797
USP21 activates DDX58.
| 1
USP21 activates DDX58. 1 / 2
| 1
eidos
"Ubiquitylation events are reversible processes , and , accordingly , severaldeubiquitylating enzymes , in particular ubiquitin specific peptidase 3 ( USP3 ) , USP21 and CYLD lysine 63 deubiquitinase ( CYLD ) , modulate RIG-I signalling by removing K63-polyubiquitin chains , although with unique kinetics ( reviewed elsewhere112 ,118 ) ."
31792373
USP21 deubiquitinates DDX58.
1 |
USP21 deubiquitinates DDX58. 1 / 1
1 |
ubibrowser
"Another study demonstrated that USP21 deubiquitinates RIG‐1, an essential protein in antiviral immune defense."
27341175
USP21 affects KCTD6
3 |
USP21 binds KCTD6. 3 / 6
3 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
USP21 affects GLI1
2 |
USP21 binds GLI1. 2 / 6
2 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
KCTD6 affects USP21
3 |
USP21 binds KCTD6. 3 / 6
3 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
GLI1 affects USP21
2 |
USP21 binds GLI1. 2 / 6
2 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
USP21 affects migration
| 5
USP21 activates migration. 5 / 5
| 5
eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."
33791299
eidos
"In non-small cell lung cancer , USP21 promotes tumor cell proliferation , migration , and invasion through the YY1 / SNHG16 axis ( Xu et al ., 2020 ) ."
33791299
eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."
33791299
eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
33791299
eidos
"USP21 amplification can increase proliferation , migration , and invasion [ 64 ] ."
32784507
USP21 affects RIPK1
1 2 1 |
USP21 binds RIPK1.
2 |
RIPK1 binds USP21. 2 / 3
2 |
biogrid
No evidence text available
19910467
biogrid
No evidence text available
19910467
USP21 deubiquitinates RIPK1.
1 1 |
USP21 deubiquitinates RIPK1. 1 / 1
1 |
ubibrowser
"The contrast in the phenotype of the Usp21-knockout line with the previously characterized GATA3 and RIPK1 knockout mice strongly indicates that USP21 is redundant for the regulation of GATA3 and RIPK1 activity during mouse development, in hematopoietic stem cells, and in lymphocyte differentiation."
25680095
USP21 deubiquitinates RIPK1 on K377. 1 / 1
1 |
biopax:reactome
No evidence text available
eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."
33791299
eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."
33791299
eidos
"USP21 amplification can increase proliferation , migration , and invasion [ 64 ] ."
32784507
eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
33791299
USP21 affects IL33
2 1 |
USP21 binds IL33.
2 |
USP21 binds IL33. 2 / 3
2 |
biogrid
No evidence text available
25197364
biogrid
No evidence text available
25197364
USP21 deubiquitinates IL33.
1 |
USP21 deubiquitinates IL33. 1 / 1
1 |
ubibrowser
"Furthermore, depletion of USP21 reduces IL-33 protein levels and IL-33-mediated NF-kappaB p65 promoter activity."
25197364
USP21 affects CUL3
2 |
USP21 binds CUL3. 2 / 4
2 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
DDX58 affects USP21
3 |
USP21 binds DDX58. 3 / 4
3 |
biogrid
No evidence text available
24493797
biogrid
No evidence text available
24493797
biogrid
No evidence text available
24493797
CUL3 affects USP21
2 |
USP21 binds CUL3. 2 / 4
2 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
Pirinixic acid affects USP21
3 |
Pirinixic acid increases the amount of USP21.
1 |
Pirinixic acid increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid decreases the amount of USP21.
1 |
Pirinixic acid decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
21318169
Pirinixic acid activates USP21.
1 |
Pirinixic acid activates USP21. 1 / 1
1 |
ctd
No evidence text available
19710929
USP21 affects MARK2
3 |
USP21 binds MARK2. 3 / 3
3 |
biogrid
No evidence text available
22298430
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22298430
USP21 affects GATA3
2 1 |
USP21 binds GATA3.
2 |
USP21 binds GATA3. 2 / 2
2 |
biogrid
No evidence text available
23395819
biogrid
No evidence text available
23395819
USP21 deubiquitinates GATA3.
1 |
USP21 deubiquitinates GATA3. 1 / 1
1 |
USP21 affects BAZ2A
1 2 |
USP21 deubiquitinates BAZ2A.
2 |
USP21 deubiquitinates BAZ2A. 2 / 2
2 |
ubibrowser
"Deubiquitinates BAZ2A/TIP5 leading to its stabilization"
26100909
ubibrowser
No evidence text available
USP21 binds BAZ2A.
1 |
USP21 binds BAZ2A. 1 / 1
1 |
biogrid
No evidence text available
26100909
RIPK1 affects USP21
2 |
RIPK1 binds USP21. 2 / 3
2 |
biogrid
No evidence text available
19910467
biogrid
No evidence text available
19910467
MARK2 affects USP21
3 |
USP21 binds MARK2. 3 / 3
3 |
biogrid
No evidence text available
22298430
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22298430
IL33 affects USP21
2 |
USP21 binds IL33. 2 / 3
2 |
biogrid
No evidence text available
25197364
biogrid
No evidence text available
25197364
Valproic acid affects USP21
2 |
Valproic acid methylates USP21.
1 |
Valproic acid methylates USP21. 1 / 1
1 |
ctd
No evidence text available
29154799
Valproic acid decreases the amount of USP21.
1 |
Valproic acid decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23179753
Bisphenol A affects USP21
2 |
Bisphenol A methylates USP21.
1 |
Bisphenol A methylates USP21. 1 / 1
1 |
ctd
No evidence text available
30906313
Bisphenol A decreases the amount of USP21.
1 |
Bisphenol A decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
25181051
USP28 affects USP21
2 |
USP21 binds USP28. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22626734
USP21 affects cell growth
| 2
USP21 activates cell growth. 2 / 2
| 2
eidos
"Mechanistically , USP21 promotes cell growth by maintaining the EZH2 protein level ."
33389794
eidos
"Mechanistically , USP21 promotes cell growth by maintaining EZH2 protein level ."
33389794
USP21 affects USP28
2 |
USP21 binds USP28. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22626734
USP21 affects USP20
2 |
USP20 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
19615732
USP21 affects USP15
2 |
USP15 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22626734
USP21 affects UCHL1
2 |
UCHL1 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
19615732
USP21 affects Neoplasms
| 1
USP21 activates Neoplasms. 1 / 2
| 1
eidos
"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."
32784507
USP21 affects MARK3
2 |
USP21 binds MARK3. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22298430
USP21 affects MARK1
2 |
USP21 binds MARK1. 2 / 2
2 |
biogrid
No evidence text available
22298430
biogrid
No evidence text available
19615732
USP21 affects Interferon
| 1
USP21 inhibits Interferon. 1 / 2
| 1
eidos
"USP21 can interact directly with STING and remove the K27 and K63 Ub chains on STING , thereby inhibiting the production of type I interferons ."
32140262
USP21 affects HIV-1
| 2
USP21 inhibits HIV-1. 2 / 2
| 2
eidos
"Here , we demonstrate that the deubiquitinase , USP21 , potently inhibits HIV-1 production by indirectly downregulating the expression of HIV-1 trans-activator of transcription ( Tat ) , which is essential for transcriptional elongation in HIV-1 ."
33827943
eidos
"Here , we screened a series of USP members and found that USP21 inhibits HIV-1 production by specifically targeting Tat , but not the other HIV-1 accessory proteins ."
33827943
USP21 affects FOXP3
1 | 1
USP21 inhibits FOXP3.
| 1
USP21 inhibits FOXP3. 1 / 1
| 1
eidos
"USP21 prevents FOXP3 degradation through deubiquination , thus stabilizing Treg phenotype and antagonizing the development of Th1-like Tregs [ 65 ] ."
28624966
USP21 deubiquitinates FOXP3.
1 |
USP21 deubiquitinates FOXP3. 1 / 1
1 |
ubibrowser
"USP21 stabilizes FOXP3 protein by mediating its deubiquitination and maintains the expression of Treg signature genes."
27857073
USP21 affects EXOSC10
1 1 |
USP21 binds EXOSC10. 2 / 2
1 1 |
hprd
No evidence text available
15231747
biogrid
No evidence text available
15231747
USP21 affects BEND3
2 |
USP21 binds BEND3. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26100909
USP20 affects USP21
2 |
USP20 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
19615732
USP15 affects USP21
2 |
USP15 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22626734
UCHL1 affects USP21
2 |
UCHL1 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
19615732
Rac5c affects USP21
| 2
Rac5c inhibits USP21. 2 / 2
| 2
eidos
"Rac5c was specific for SARS2 PLpro and did not inhibit USP21 even at the highest concentration of 100 muM ."
32845033
eidos
"Rac5c was specific for SARS2 PLpro and did not inhibit USP21 551 even at the highest concentration of 100 muM ."
| DOI
Plant Extracts affects USP21
2 |
Plant Extracts increases the amount of USP21.
1 |
Plant Extracts increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23557933
Plant Extracts decreases the amount of USP21.
1 |
Plant Extracts decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23557933
MARK3 affects USP21
2 |
USP21 binds MARK3. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22298430
MARK1 affects USP21
2 |
USP21 binds MARK1. 2 / 2
2 |
biogrid
No evidence text available
22298430
biogrid
No evidence text available
19615732
GATA3 affects USP21
2 |
USP21 binds GATA3. 2 / 2
2 |
biogrid
No evidence text available
23395819
biogrid
No evidence text available
23395819
EXOSC10 affects USP21
1 1 |
USP21 binds EXOSC10. 2 / 2
1 1 |
hprd
No evidence text available
15231747
biogrid
No evidence text available
15231747
BEND3 affects USP21
2 |
USP21 binds BEND3. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26100909
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP21.
1 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
17942748
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP21.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
21215274
Vinclozolin affects USP21
1 |
Vinclozolin increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23034163
Tert-butyl hydroperoxide decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
15336504
Rotenone affects USP21
1 |
Rotenone decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23186747
Rac5c affects USP21
| 1
Rac5c inhibits USP21. 1 / 1
| 1
eidos
"This contrasted with rac5c , which inhibited PLpro , 197 but did not inhibit USP21 even at 100 muM concentration ( Figure 3b ) .7 SARS PLpro inhibitors against SARS2 PLpro206 SARS PLpro has been the focus of academic drug discovery efforts in the last two 207 decades 3 ."
| DOI
Phorbol 13-acetate 12-myristate decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
25613284
Pentabromodiphenyl ether decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23948077
Paracetamol affects USP21
1 |
Paracetamol decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
26690555
Overexpression myristoylated Akt affects USP21
| 1
Overexpression myristoylated Akt activates USP21. 1 / 1
| 1
eidos
"Additionally , overexpression of myristoylated Akt increased USP2-1 expression in hepatoma , which was accompanied by high levels of expression of lipogenic proteins including FASN , acetyl-CoA carboxylase , and adenosine triphosphate citrate lyase [ 19 ] ."
33530560
Methylazoxymethanol increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
17107856
Ionomycin affects USP21
1 |
Ionomycin decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
25613284
Immune activation affects USP21
| 1
Immune activation activates USP21. 1 / 1
| 1
eidos
"Alternatively , immune activation could activate USP21 post-translationally , thereby providing an activated feedback ."
33808506
Hsa-miR-93-5p affects USP21
1 |
Hsa-miR-93-5p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-744-5p affects USP21
1 |
Hsa-miR-744-5p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-671-5p affects USP21
1 |
Hsa-miR-671-5p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-331-3p affects USP21
1 |
Hsa-miR-331-3p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-32-5p affects USP21
1 |
Hsa-miR-32-5p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hexabromocyclododecane increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
29177809
Folic acid affects USP21
1 |
Folic acid methylates USP21. 1 / 1
1 |
ctd
No evidence text available
20938992
Doxorubicin affects USP21
1 |
Doxorubicin decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
29803840
Dibutyl phthalate affects USP21
1 |
Dibutyl phthalate decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
21266533
Choline affects USP21
1 |
Choline methylates USP21. 1 / 1
1 |
ctd
No evidence text available
20938992
Cadmium dichloride demethylates USP21. 1 / 1
1 |
ctd
No evidence text available
22457795
Butanal affects USP21
1 |
Butanal decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
26079696
Atrazine affects USP21
1 |
Atrazine increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
22378314
Assays affects USP21
| 1
Assays activates USP21. 1 / 1
| 1
eidos
"In addition , we tested USP14 because it can antagonize proteasomal degradation ( Lee et al ., 2010 ) , as well as USP21 because it is highly active in many in vitro assays ."
33417828
Aflatoxin B1 affects USP21
1 |
Aflatoxin B1 methylates USP21. 1 / 1
1 |
ctd
No evidence text available
27153756
Abrine affects USP21
1 |
Abrine increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
31054353
ZNF638 affects USP21
1 |
USP21 binds ZNF638. 1 / 1
1 |
biogrid
No evidence text available
27173435
ZNF350 affects USP21
1 |
USP21 binds ZNF350. 1 / 1
1 |
biogrid
No evidence text available
27621083
ZIC1 affects USP21
1 |
ZIC1 decreases the amount of USP21. 1 / 1
1 |
biopax:msigdb
No evidence text available
ZBTB21 affects USP21
1 |
USP21 binds ZBTB21. 1 / 1
1 |
biogrid
No evidence text available
27173435
YOD1 affects USP21
1 |
USP21 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
XPO1 affects USP21
1 |
USP21 binds XPO1. 1 / 1
1 |
biogrid
No evidence text available
21888622
WDR47 affects USP21
1 |
USP21 binds WDR47. 1 / 1
1 |
biogrid
No evidence text available
27621083
UTRN affects USP21
1 |
USP21 binds UTRN. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP8 affects USP21
1 |
USP21 binds USP8. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP7 affects USP21
1 |
USP21 binds USP7. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP51 affects USP21
1 |
USP21 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP48 affects USP21
1 |
USP21 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP4 affects USP21
1 |
USP21 binds USP4. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP33 affects USP21
1 |
USP21 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21
1 |
USP21 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects viability colony MKN-45 cells
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USP21 inhibits viability colony MKN-45 cells. 1 / 1
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eidos
"The results exhibited that overexpression of USP21 notably improved the viability and colony forming ability of AGS cells while inhibiting the expression of USP21 conspicuously reduced the viability and colony forming ability of MKN-45 cells ( Figures 2C , D ) ."
33791299
USP21 affects ubiquitination FOXM1
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USP21 inhibits ubiquitination FOXM1. 1 / 1
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eidos
"HDACi treatment increased the ubiquitination level of FOXM1 by suppressing ubiquitin-specific peptidase 21 ( USP21 ) , which deubiquitinates FOXM1 ."
34335925
USP21 affects tumorigenicity cells
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USP21 activates tumorigenicity cells. 1 / 1
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eidos
"Moreover , USP21 could promote the malignant transformation of the normal human hepatocytes and increased the tumorigenicity of the HCC cells by activating the ERK signaling through the stabilization of MEK2 ( 11 ) ."
33718205
USP21 affects tumor cell
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USP21 activates tumor cell. 1 / 1
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eidos
"In non-small cell lung cancer , USP21 promotes tumor cell proliferation , migration , and invasion through the YY1 / SNHG16 axis ( Xu et al ., 2020 ) ."
33791299
USP21 activates transcription, DNA-templated. 1 / 1
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eidos
"Besides , USP21 could promote transcription by deubiquitylating ubH2A in vitro [ 46 ] ."
33546726
USP21 affects stemness
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USP21 activates stemness. 1 / 1
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eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."
33791299
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