IndraLab

Statements


USP21 affects NANOG
8 1 | 1
USP21 binds NANOG.
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USP21 deubiquitinates NANOG.
1 | 1
USP21 deubiquitinates NANOG. 2 / 2
1 | 1

reach
"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."
USP21 is modified
8 | 1 3
USP21 is phosphorylated.
6 | 3
USP21 is phosphorylated on S116. 2 / 2
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USP21 is phosphorylated on T132. 2 / 2
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USP21 is phosphorylated. 2 / 2
| 2

rlimsp
"p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation."

rlimsp
"Thus, our study reveals a critical role of p38-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses."
USP21 is phosphorylated on S140. 2 / 2
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USP21 is phosphorylated on S538. 1 / 1
| 1

rlimsp
"HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation of USP21 at Ser538."
USP21 is acetylated.
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USP21 is acetylated on S113. 2 / 2
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USP21 is deubiquitinated.
| 1
USP21 is deubiquitinated. 1 / 1
| 1

trips
"Deubiquitinating enzyme USP21 inhibits HIV-1 replication by downregulating Tat expression."
NANOG affects USP21
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eidos
"Therefore , USP21 stimulates cell proliferation but cannot cause cell death ."

eidos
"We identify that knockdown of USP21 inhibits cell proliferation , and overexpression of USP21 promotes cell growth ."

eidos
"These data demonstrate that USP21 promotes cell proliferation via its deubiquitinating active site ."

eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."

eidos
"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."

eidos
"USP21 promotes cell proliferation via Cys-221 ."

eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."

eidos
"USP21 knockdown or overexpression in the DLBCL cell line shows that USP21 promotes cell proliferation ."

eidos
"USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma MA et al. Abstract Background Diffuse large B-cell lymphoma ( DLBCL ) is the most common category of non-Hodgkin lymphoma ( NHL ) ."
USP21 affects UBC
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USP21 affects DDX58
3 1 | 1
USP21 binds DDX58.
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USP21 activates DDX58.
| 1
USP21 activates DDX58. 1 / 2
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eidos
"Ubiquitylation events are reversible processes , and , accordingly , severaldeubiquitylating enzymes , in particular ubiquitin specific peptidase 3 ( USP3 ) , USP21 and CYLD lysine 63 deubiquitinase ( CYLD ) , modulate RIG-I signalling by removing K63-polyubiquitin chains , although with unique kinetics ( reviewed elsewhere112 ,118 ) ."
USP21 deubiquitinates DDX58.
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USP21 deubiquitinates DDX58. 1 / 1
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"Another study demonstrated that USP21 deubiquitinates RIG‐1, an essential protein in antiviral immune defense."
USP21 affects KCTD6
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USP21 affects GLI1
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KCTD6 affects USP21
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GLI1 affects USP21
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USP21 affects migration
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USP21 activates migration. 5 / 5
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eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."

eidos
"In non-small cell lung cancer , USP21 promotes tumor cell proliferation , migration , and invasion through the YY1 / SNHG16 axis ( Xu et al ., 2020 ) ."

eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."

eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."

eidos
"USP21 amplification can increase proliferation , migration , and invasion [ 64 ] ."
USP21 affects RIPK1
1 2 1 |
USP21 binds RIPK1.
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USP21 deubiquitinates RIPK1.
1 1 |
USP21 deubiquitinates RIPK1. 1 / 1
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"The contrast in the phenotype of the Usp21-knockout line with the previously characterized GATA3 and RIPK1 knockout mice strongly indicates that USP21 is redundant for the regulation of GATA3 and RIPK1 activity during mouse development, in hematopoietic stem cells, and in lymphocyte differentiation."
USP21 deubiquitinates RIPK1 on K377. 1 / 1
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eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."

eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."

eidos
"USP21 amplification can increase proliferation , migration , and invasion [ 64 ] ."

eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
USP21 affects IL33
2 1 |
USP21 binds IL33.
2 |
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USP21 deubiquitinates IL33.
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USP21 deubiquitinates IL33. 1 / 1
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"Furthermore, depletion of USP21 reduces IL-33 protein levels and IL-33-mediated NF-kappaB p65 promoter activity."
USP21 affects CUL3
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DDX58 affects USP21
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CUL3 affects USP21
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Pirinixic acid increases the amount of USP21.
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Pirinixic acid increases the amount of USP21. 1 / 1
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Pirinixic acid decreases the amount of USP21.
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Pirinixic acid decreases the amount of USP21. 1 / 1
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Pirinixic acid activates USP21.
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USP21 affects MARK2
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USP21 affects GATA3
2 1 |
USP21 binds GATA3.
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USP21 deubiquitinates GATA3.
1 |
USP21 deubiquitinates GATA3. 1 / 1
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USP21 affects BAZ2A
1 2 |
USP21 deubiquitinates BAZ2A.
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USP21 deubiquitinates BAZ2A. 2 / 2
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"Deubiquitinates BAZ2A/TIP5 leading to its stabilization"

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USP21 binds BAZ2A.
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RIPK1 affects USP21
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MARK2 affects USP21
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IL33 affects USP21
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Valproic acid methylates USP21.
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Valproic acid decreases the amount of USP21.
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Valproic acid decreases the amount of USP21. 1 / 1
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Bisphenol A affects USP21
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Bisphenol A methylates USP21.
1 |
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Bisphenol A decreases the amount of USP21.
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Bisphenol A decreases the amount of USP21. 1 / 1
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USP28 affects USP21
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USP21 affects cell growth
| 2
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eidos
"Mechanistically , USP21 promotes cell growth by maintaining the EZH2 protein level ."

eidos
"Mechanistically , USP21 promotes cell growth by maintaining EZH2 protein level ."
USP21 affects USP28
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USP21 affects USP20
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USP21 affects USP15
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USP21 affects UCHL1
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USP21 affects Neoplasms
| 1
| 1

eidos
"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."
USP21 affects MARK3
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USP21 affects MARK1
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USP21 affects Interferon
| 1
| 1

eidos
"USP21 can interact directly with STING and remove the K27 and K63 Ub chains on STING , thereby inhibiting the production of type I interferons ."
USP21 affects HIV-1
| 2
USP21 inhibits HIV-1. 2 / 2
| 2

eidos
"Here , we demonstrate that the deubiquitinase , USP21 , potently inhibits HIV-1 production by indirectly downregulating the expression of HIV-1 trans-activator of transcription ( Tat ) , which is essential for transcriptional elongation in HIV-1 ."

eidos
"Here , we screened a series of USP members and found that USP21 inhibits HIV-1 production by specifically targeting Tat , but not the other HIV-1 accessory proteins ."
USP21 affects FOXP3
1 | 1
USP21 inhibits FOXP3.
| 1
USP21 inhibits FOXP3. 1 / 1
| 1

eidos
"USP21 prevents FOXP3 degradation through deubiquination , thus stabilizing Treg phenotype and antagonizing the development of Th1-like Tregs [ 65 ] ."
USP21 deubiquitinates FOXP3.
1 |
USP21 deubiquitinates FOXP3. 1 / 1
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"USP21 stabilizes FOXP3 protein by mediating its deubiquitination and maintains the expression of Treg signature genes."
USP21 affects EXOSC10
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USP21 affects BEND3
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USP20 affects USP21
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USP15 affects USP21
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UCHL1 affects USP21
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Rac5c affects USP21
| 2
Rac5c inhibits USP21. 2 / 2
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eidos
"Rac5c was specific for SARS2 PLpro and did not inhibit USP21 even at the highest concentration of 100 muM ."

eidos
"Rac5c was specific for SARS2 PLpro and did not inhibit USP21 551 even at the highest concentration of 100 muM ."
| DOI
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Plant Extracts increases the amount of USP21.
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Plant Extracts increases the amount of USP21. 1 / 1
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No evidence text available
Plant Extracts decreases the amount of USP21.
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Plant Extracts decreases the amount of USP21. 1 / 1
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MARK3 affects USP21
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MARK1 affects USP21
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GATA3 affects USP21
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EXOSC10 affects USP21
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BEND3 affects USP21
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2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP21.
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2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP21.
1 |
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No evidence text available
Vinclozolin affects USP21
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Vinclozolin increases the amount of USP21. 1 / 1
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No evidence text available
Tert-butyl hydroperoxide decreases the amount of USP21. 1 / 1
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Rotenone affects USP21
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Rotenone decreases the amount of USP21. 1 / 1
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Rac5c affects USP21
| 1
Rac5c inhibits USP21. 1 / 1
| 1

eidos
"This contrasted with rac5c , which inhibited PLpro , 197 but did not inhibit USP21 even at 100 muM concentration ( Figure 3b ) .7 SARS PLpro inhibitors against SARS2 PLpro206 SARS PLpro has been the focus of academic drug discovery efforts in the last two 207 decades 3 ."
| DOI
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Pentabromodiphenyl ether decreases the amount of USP21. 1 / 1
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Paracetamol affects USP21
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Paracetamol decreases the amount of USP21. 1 / 1
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Overexpression myristoylated Akt affects USP21
| 1
Overexpression myristoylated Akt activates USP21. 1 / 1
| 1

eidos
"Additionally , overexpression of myristoylated Akt increased USP2-1 expression in hepatoma , which was accompanied by high levels of expression of lipogenic proteins including FASN , acetyl-CoA carboxylase , and adenosine triphosphate citrate lyase [ 19 ] ."
Methylazoxymethanol increases the amount of USP21. 1 / 1
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No evidence text available
Ionomycin affects USP21
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Ionomycin decreases the amount of USP21. 1 / 1
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Immune activation affects USP21
| 1
Immune activation activates USP21. 1 / 1
| 1

eidos
"Alternatively , immune activation could activate USP21 post-translationally , thereby providing an activated feedback ."
1 |
Hsa-miR-93-5p decreases the amount of USP21. 1 / 1
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No evidence text available
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Hsa-miR-744-5p decreases the amount of USP21. 1 / 1
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No evidence text available
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Hsa-miR-671-5p decreases the amount of USP21. 1 / 1
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Hsa-miR-331-3p decreases the amount of USP21. 1 / 1
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Hsa-miR-32-5p decreases the amount of USP21. 1 / 1
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Hexabromocyclododecane increases the amount of USP21. 1 / 1
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No evidence text available
Folic acid affects USP21
1 |
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Doxorubicin affects USP21
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Doxorubicin decreases the amount of USP21. 1 / 1
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No evidence text available
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Dibutyl phthalate decreases the amount of USP21. 1 / 1
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Choline affects USP21
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Choline methylates USP21. 1 / 1
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No evidence text available
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Butanal affects USP21
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Butanal decreases the amount of USP21. 1 / 1
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No evidence text available
Atrazine affects USP21
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Atrazine increases the amount of USP21. 1 / 1
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Assays affects USP21
| 1
Assays activates USP21. 1 / 1
| 1

eidos
"In addition , we tested USP14 because it can antagonize proteasomal degradation ( Lee et al ., 2010 ) , as well as USP21 because it is highly active in many in vitro assays ."
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Abrine affects USP21
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Abrine increases the amount of USP21. 1 / 1
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No evidence text available
ZNF638 affects USP21
1 |
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No evidence text available
ZNF350 affects USP21
1 |
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ZIC1 affects USP21
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ZIC1 decreases the amount of USP21. 1 / 1
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No evidence text available
ZBTB21 affects USP21
1 |
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YOD1 affects USP21
1 |
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XPO1 affects USP21
1 |
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WDR47 affects USP21
1 |
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UTRN affects USP21
1 |
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USP8 affects USP21
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USP7 affects USP21
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USP51 affects USP21
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USP48 affects USP21
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USP4 affects USP21
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USP33 affects USP21
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USP21 affects viability colony MKN-45 cells
| 1
USP21 inhibits viability colony MKN-45 cells. 1 / 1
| 1

eidos
"The results exhibited that overexpression of USP21 notably improved the viability and colony forming ability of AGS cells while inhibiting the expression of USP21 conspicuously reduced the viability and colony forming ability of MKN-45 cells ( Figures 2C , D ) ."
USP21 affects ubiquitination FOXM1
| 1
USP21 inhibits ubiquitination FOXM1. 1 / 1
| 1

eidos
"HDACi treatment increased the ubiquitination level of FOXM1 by suppressing ubiquitin-specific peptidase 21 ( USP21 ) , which deubiquitinates FOXM1 ."
USP21 affects tumorigenicity cells
| 1
USP21 activates tumorigenicity cells. 1 / 1
| 1

eidos
"Moreover , USP21 could promote the malignant transformation of the normal human hepatocytes and increased the tumorigenicity of the HCC cells by activating the ERK signaling through the stabilization of MEK2 ( 11 ) ."
USP21 affects tumor cell
| 1
USP21 activates tumor cell. 1 / 1
| 1

eidos
"In non-small cell lung cancer , USP21 promotes tumor cell proliferation , migration , and invasion through the YY1 / SNHG16 axis ( Xu et al ., 2020 ) ."

eidos
"Besides , USP21 could promote transcription by deubiquitylating ubH2A in vitro [ 46 ] ."
USP21 affects stemness
| 1
USP21 activates stemness. 1 / 1
| 1

eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."
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