IndraLab

Statements

OTUD4 is modified
9 | 57
OTUD4 is methylated.
| 42
OTUD4 is methylated. 10 / 42
| 42
sparser
"For this study, 514 samples obtained from 150 women were assessed cytologically and by Quantitative Multiplex Methylation-Specific PCR (QM-MSP) for methylation of cyclin D2, APC, HIN1, RASSF1A, and RAR-beta2."
| PMC
sparser
"In situ case tumors had more frequent methylation of HIN1 than invasive cancers (P=0.02)."
21837480
sparser
"Methylation of cyclin D2, APC, HIN1, RASSF1A, and RAR-beta2 was measured by quantitative multiplex methylation-specific PCR in 290 benign and malignant breast epithelial cell samples obtained by palpation-directed fine-needle aspiration biopsy from 164 women."
18483325
sparser
"The high specificity of HIN1 methylation in discriminating patients with NPC from normal individuals indicates its role as a tumor marker for NPC."
21439244
sparser
"CYCLIND2, GSTP1 , and HIN1 promoter methylation also appeared to modify the associations between obesity and BC-specific mortality, but the interaction was of borderline significance ( p < 0.10)."
26945992
sparser
"Certain genes methylated in precursor lesions of the esophagus demonstrate that DNA methylation may serve as esophageal cancer early detection marker, such as methylation of HIN1 , TFPI-2 , DACH1 , and SOX17."
27110300
sparser
"Synthetic log use was associated with elevated odds of HIN1 methylation (OR=2.14, 95%CI=1.34–3.42) and CDH1 methylation (OR=2.26, 95%CI=1.06–4.79) ( Table 4 )."
26671626
sparser
"Cases with detectable adducts were less likely to have a methylated HIN1 gene(ROR=0.66, 95%CI 0.42-1.05), although the confidence intervals included the null value and the interaction was not statistically significant (p ≥ 0.10)."
26407953
sparser
"Cumulative RASSF1A, TWIST1, and HIN1 gene methylation accurately distinguished ducts with cancerous versus benign lesions (100% sensitivity, 72% specificity, and area under the curve of 0.91 according to receiving operating characteristic analyses)."
19470737
sparser
"For heterogeneity analysis, AP2 methylation heterogeneity is associated with tumor size ( P < 0.01), CDH1 methylation heterogeneity is associated with lymph node metastasis ( P < 0.05), DACT2 methylation heterogeneity is associated with tumor size ( P < 0.01), HIN1 methylation heterogeneity is associated with tumor size and extra-thyroidal extension (all P < 0.01)."
34539742
OTUD4 is phosphorylated.
9 | 14
OTUD4 is phosphorylated. 10 / 14
| 14
sparser
"Studies have confirmed that casein kinase II (CK2) induces the phosphorylation of OTUD4 at residues Ser202, which is adjacent to the catalytic OTU domain ( xref )."
34177595
sparser
"This activity depends on the phosphorylation of OTUD4 near its catalytic domain ( xref ) as well as a putative UIM motif adjacent to the OTU domain ( xref )."
29395066
sparser
"In this study, we show that OTUD4, a K48-specific deubiquitinase which we previously showed to be important for maintaining the stability of alkylation repair enzymes ( xref ), has a completely distinct function in modulating innate immune signaling via NF-κB. We find that OTUD4 is phosphorylated in vivo , activating an unrecognized K63-linked deubiquitinase activity."
29395066
sparser
"Knockdown of the kinase CK2α or CK2α prime, or both in HEK293 cells decreased phosphorylation of purified OTUD4, and similarly impaired OTUD4 K63 DUB activity ( xref and xref )."
29395066
sparser
"In contrast, the phosphorylation of OTUD4 occurs at a SXXE/D motif xref which is recognised by the kinase casein kinase 2 (CK2) xref , xref ."
32973272
sparser
"Furthermore, CKII-induced phosphorylation of OTUD4 promoted the preferential hydrolysis of the Ub chain changed from K48- to K63-linked chains, which plays an essential role in innate immune signalling ( xref )."
34177595
sparser
"Zhao et al. demonstrate that OTUD4 is phosphorylated near its catalytic domain, activating a dormant K63-specific deubiquitinase activity."
29395066
sparser
"Whether or not OTUD4 is also phosphorylated when acting in these different compartments requires further investigation."
32973272
sparser
"Recent evidence however, has revealed that phosphorylation of OTUD4 can alter the enzymatic activity of the protein, permitting a K63-linkage specific deubiquitination of the Toll like receptor/ Interleukin-1 receptor (TLR/IL-1R) associated factor, MyD88 xref ."
32973272
sparser
"In addition, phosphorylation of OTUD4 confers K63 deubiquitinase activity, allowing it to deubiquitinate MyD88 and subsequently deactivate TLR-mediated NF-κB signaling [ xref ]."
32365080
OTUD4 is phosphorylated on S940. 9 / 9
9 |
hprd
No evidence text available
19664995
hprd
No evidence text available
19413330
hprd
No evidence text available
18669648
hprd
No evidence text available
19664994
hprd
No evidence text available
15302935
hprd
No evidence text available
16964243
hprd
No evidence text available
20058876
hprd
No evidence text available
19651622
hprd
No evidence text available
18767875
OTUD4 is ubiquitinated.
| 1
OTUD4 is ubiquitinated. 1 / 1
| 1
sparser
"FIGURE 5: ICP0-mediated ubiquitination of OTUD4 and VIM. (A) Venn diagram showing 12 proteins identified by both ICP0 interactome and ubiquitinome analyses. (B) Summary of ubiquitination sites on VIM (upper) and OTUD4 (lower)."
35516420
OTUD4 affects XPC
1 | 2 4
OTUD4 binds XPC.
| 4
XPC binds OTUD4. 4 / 4
| 4
sparser
"We validated the XPC-OTUD4 interaction by co-IP and demonstrated that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by removing the ubiquitin moiety."
24366067
sparser
"We found that XPC and OTUD4 interact directly in a co-immunoprecipitation experiment ( xref )."
24366067
sparser
"In addition, we have validated the OTUD4–XPC interaction in Human cells."
24366067
sparser
"Importantly, we validated the XPC-OTUD4 interaction by co-IP and provided evidence that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by cleaving the ubiquitin moiety."
24366067
OTUD4 deubiquitinates XPC.
1 | 2
OTUD4 deubiquitinates XPC. 3 / 3
1 | 2
reach
"We speculate that deubiquitination of XPC by OTUD4 could be responsible for the removal of XPC from damage sites, possibly leading to XPC recycling."
24366067
reach
"It is not known whether OTUD4 works independently or cooperatively with USP7 to deubiquitinate XPC."
27696486
ubibrowser
"Importantly, we validated the XPC-OTUD4 interaction by co-IP and provided evidence that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by cleaving the ubiquitin moiety."
24366067
OTUD4 affects MAVS
1 | 3 2
OTUD4 deubiquitinates MAVS.
1 | 2
OTUD4 deubiquitinates MAVS. 3 / 3
1 | 2
reach
"That study showed that OTUD4 deubiquitinates and stabilizes MAVS, thereby activating downstream signaling in the RIG-I like receptor RNA sensing pathway."
35516420
reach
"However, OTUD4 positively regulates IFN signaling and enhances host antiviral activities by deubiquitinating K48-Ub on MAVS (66)."
34707613
ubibrowser
"Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS"
30410068
OTUD4 binds MAVS.
| 2
OTUD4 binds MAVS. 2 / 2
| 2
sparser
"The deubiquitinase OTUD4 interacts with MAVS to remove its K48-linked polyubiquitin chains and thereby maintains MAVS stability and promotes innate antiviral signaling."
34707613
sparser
"Viral infection leads to the IRF3/7-dependent upregulation of OTUD4 which interacts with MAVS to remove K48-linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling."
30410068
OTUD4 activates MAVS.
| 1
OTUD4 activates MAVS. 1 / 1
| 1
reach
"OTUD4, a deubiquitinase, enhances MAVS mediated signaling by stabilizing MAVS and by eliminating K48 linked ubiquitins."
33462384
USP9X affects OTUD4
3 | 1 1
USP9X binds OTUD4. 5 / 5
3 | 1 1
biogrid
No evidence text available
25944111
reach
"Characterization of ALKBH3 interacting proteins show that USP7 and USP9x associate with another DUB OTU deubiquitinase 4 (OTUD4) to form a protein complex that deubiquitinates ALKBH3 [XREF_BIBR]."
30831436
biogrid
No evidence text available
25944111
sparser
"If indeed OTUD4-bound USP9X can affect TβR deubiquitination, it may explain both the catalytic and non-catalytic functions of OTUD4 in TGFβ regulation."
32973272
biogrid
No evidence text available
25944111
USP7 affects OTUD4
4 | 1
USP7 binds OTUD4. 5 / 5
4 | 1
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
reach
"Characterization of ALKBH3 interacting proteins show that USP7 and USP9x associate with another DUB OTU deubiquitinase 4 (OTUD4) to form a protein complex that deubiquitinates ALKBH3 [XREF_BIBR]."
30831436
OTUD4 affects USP9X
3 | 1 1
USP9X binds OTUD4. 5 / 5
3 | 1 1
biogrid
No evidence text available
25944111
reach
"Characterization of ALKBH3 interacting proteins show that USP7 and USP9x associate with another DUB OTU deubiquitinase 4 (OTUD4) to form a protein complex that deubiquitinates ALKBH3 [XREF_BIBR]."
30831436
biogrid
No evidence text available
25944111
sparser
"If indeed OTUD4-bound USP9X can affect TβR deubiquitination, it may explain both the catalytic and non-catalytic functions of OTUD4 in TGFβ regulation."
32973272
biogrid
No evidence text available
25944111
OTUD4 affects USP7
4 | 1
USP7 binds OTUD4. 5 / 5
4 | 1
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
reach
"Characterization of ALKBH3 interacting proteins show that USP7 and USP9x associate with another DUB OTU deubiquitinase 4 (OTUD4) to form a protein complex that deubiquitinates ALKBH3 [XREF_BIBR]."
30831436
OTUD4 affects ALKBH3
4 | 1
OTUD4 binds ALKBH3.
4 |
OTUD4 binds ALKBH3. 4 / 4
4 |
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
OTUD4 deubiquitinates ALKBH3.
| 1
OTUD4 deubiquitinates ALKBH3. 1 / 1
| 1
reach
"Besides USP11, OTUD4 is another USP7 partner that deubiquitinates DNA demethylases ALKBH2 and ALKBH3 [118]."
33991872
OTUD4 affects AKT
| 5
OTUD4 inhibits AKT.
| 2
OTUD4 inhibits AKT. 2 / 2
| 2
reach
"Akt pathway activity repressed by HIN-1 was enhanced in HIF-2alpha-deficient human NSCLC cells and xenografts [XREF_BIBR]."
22871047
reach
"Expression of HIN-1 also inhibits Akt mediated retention of p27 in the cytoplasm."
| PMC
OTUD4 phosphorylates AKT.
| 1
OTUD4 leads to the phosphorylation of AKT. 1 / 1
| 1
reach
"Our results indicate that restoration of HIN-1 can enhance the susceptibility of cytotoxic drugs and increase the apoptosis related enzyme activities in H1N-1-transfected cancer cells by influencing the Akt phosphorylation."
22871047
OTUD4 decreases the amount of AKT.
| 1
Modified OTUD4 decreases the amount of phosphorylated AKT. 1 / 1
| 1
reach
"Furthermore, overexpression of HIN-1 reduces the expression of phosphorated-AKT (p-AKT), c-myc, Bcl-2 and cyclinD1 while Bax was increased."
22095135
OTUD4 activates AKT.
| 1
OTUD4 activates AKT. 1 / 1
| 1
reach
"AKT signaling pathway activated by HIN-1 methylation in non small cell lung cancer."
22095135
ICP0 affects OTUD4
| 3 2
ICP0 ubiquitinates OTUD4.
| 1 2
ICP0 ubiquitinates OTUD4. 3 / 3
| 1 2
sparser
"Indeed, we confirmed that both OTUD4 and VIM could be ubiquitinated by ICP0."
35516420
reach
"To examine whether VIM and OTUD4 were ubiquitinated by ICP0, we co-transfected ubiquitin, VIM or OTUD4, and ICP0 or its control (empty vector or ring finger mutant) into Neuro-2a cells before immunoprecipitation of VIM and OTUD4 and analysis of ubiquitination levels by Western blots."
35516420
sparser
"To examine whether VIM and OTUD4 were ubiquitinated by ICP0, we co-transfected ubiquitin, VIM or OTUD4, and ICP0 or its control (empty vector or ring finger mutant) into Neuro-2a cells before immunoprecipitation of VIM and OTUD4 and analysis of ubiquitination levels by Western blots."
35516420
ICP0 inhibits OTUD4.
| 2
ICP0 inhibits OTUD4. 2 / 2
| 2
reach
"However, in KOS-infected cells, neither overexpressing nor knocking down OTUD4 had a significant effect indicating an ICP0-dependent block of OTUD4 activity."
35516420
reach
"Comparison of WT and RFm viruses showed no indication of ICP0-induced degradation of OTUD4 or VIM at later times (Figure 6A)."
35516420
Harpin affects OTUD4
| 4
Harpin activates OTUD4.
| 3
Harpin activates OTUD4. 3 / 3
| 3
reach
"This showed that the harpin induced 1 (HIN1) gene is responsive to Spm."
15316293
reach
"The higher expression of HR marker genes, harpin-induced 1 (Hin1) and hypersensitivity-related (Hsr203JI), supported the role of C1 and Rep in HR response in plants."
35960462
reach
"In contrast to activation by beta-megaspermin, harpin (Psph)-induced activation of the 48-kD salicylic acid responsive mitogen activated protein kinase (MAPK) and HIN1 transcript accumulation were independent of extracellular calcium."
11340183
Harpin inhibits OTUD4.
| 1
Harpin inhibits OTUD4. 1 / 1
| 1
reach
"Inhibition of MAP kinase pathways, demonstrated by lack of SIPK kinase activity, affected elicitor induced accumulation of HIN1 transcript in tobacco cells treated with harpin from P. syringae pv."
11597498
XPC affects OTUD4
| 4
XPC binds OTUD4. 4 / 4
| 4
sparser
"We validated the XPC-OTUD4 interaction by co-IP and demonstrated that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by removing the ubiquitin moiety."
24366067
sparser
"We found that XPC and OTUD4 interact directly in a co-immunoprecipitation experiment ( xref )."
24366067
sparser
"In addition, we have validated the OTUD4–XPC interaction in Human cells."
24366067
sparser
"Importantly, we validated the XPC-OTUD4 interaction by co-IP and provided evidence that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by cleaving the ubiquitin moiety."
24366067
OTUD4 affects TGFB
| 2 1 1
OTUD4 activates TGFB.
| 2 1
OTUD4 activates TGFB. 3 / 3
| 2 1
reach
"OTUD4 enhances TGFbeta signalling through regulation of the TGFbeta receptor complex."
32973272
eidos
"Specifically , we find that OTUD4 enhances TGFbeta signalling by promoting the membrane presence of TGFbeta receptor I. Furthermore , we demonstrate that OTUD4 inactivates the TGFbeta negative regulator SMURF2 suggesting that OTUD4 regulates multiple nodes of the TGFbeta pathway to enhance TGFbeta activity ."
32973272
eidos
"OTUD4 enhances TGFbeta signalling through regulation of the TGFbeta receptor complex ."
32973272
OTUD4 binds TGFB.
| 1
TGFB binds OTUD4. 1 / 1
| 1
sparser
"We therefore sought to validate whether or not OTUD4 interacted with components of the TGFβ receptor complex."
32973272
OTUD4 affects RNF216
| 2 2
OTUD4 binds RNF216.
| 1 2
RNF216 binds OTUD4. 3 / 3
| 1 2
reach
"This possibility is bolstered by the observation of epistatic interactions between RNF216 and OTUD4, with simultaneous knockdown of both genes resulting in more severe phenotypes."
23656588
sparser
"Mutations in the ubiquitin ligase RNF216 and the deubiquitianse OTUD4 also associate with GHS."
27081508
sparser
"Indeed, the phenotype in the index pedigree appears to have been caused by the interaction of hypomorphic mutations in RNF216 and OTUD4 ."
23656588
OTUD4 inhibits RNF216.
| 1
OTUD4 inhibits RNF216. 1 / 1
| 1
reach
"The syndrome of hypogonadotropic hypogonadism, ataxia, and dementia can be caused by inactivating mutations in RNF216 or by the combination of mutations in RNF216 and OTUD4."
23656588
OTUD4 affects MYD88
| 4
OTUD4 binds MYD88. 4 / 4
| 4
sparser
"On the other hand, the amount of MyD88 associated with OTUD4 appeared minimally changed under the same conditions ( xref )."
29395066
sparser
"Immunoprecipitation of OTUD4 from mouse embryonic fibroblast (MEF) cell extracts demonstrated the interaction between OTUD4 and MyD88, suggesting that this interaction exists at the endogenous level ( xref )."
29395066
sparser
"Taken together, these results demonstrated that OTUD4 associates directly with MyD88."
29395066
sparser
"We confirmed the interaction of OTUD4 with MyD88 by immunoprecipitation (IP) of Flag-tagged MyD88, along with HA-tagged OTUD4 co-expressed in HEK293 cells ( xref )."
29395066
ALKBH3 affects OTUD4
4 |
OTUD4 binds ALKBH3. 4 / 4
4 |
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
biogrid
No evidence text available
25944111
Bisphenol A affects OTUD4
3 |
Bisphenol A increases the amount of OTUD4.
2 |
Bisphenol A increases the amount of OTUD4. 2 / 2
2 |
ctd
No evidence text available
25181051
ctd
No evidence text available
30816183
Bisphenol A decreases the amount of OTUD4.
1 |
Bisphenol A decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26063408
UBC affects OTUD4
3 |
UBC binds OTUD4. 3 / 3
3 |
biogrid
No evidence text available
28190767
biogrid
No evidence text available
25944111
biogrid
No evidence text available
23827681
SMN2 affects OTUD4
| 3
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
SMN2 binds OTUD4. 1 / 1
| 1
sparser
"Because OTUD4 interacted with SMN1 in co-IPs and SMN1 has been well characterized in neuronal RNP granules ( xref ; xref ), we co-expressed mOrange2–OTUD4 with neonGreen–SMN1 in hippocampal neurons for live-cell imaging."
31138677
RNF216 affects OTUD4
| 1 2
RNF216 binds OTUD4. 3 / 3
| 1 2
reach
"This possibility is bolstered by the observation of epistatic interactions between RNF216 and OTUD4, with simultaneous knockdown of both genes resulting in more severe phenotypes."
23656588
sparser
"Mutations in the ubiquitin ligase RNF216 and the deubiquitianse OTUD4 also associate with GHS."
27081508
sparser
"Indeed, the phenotype in the index pedigree appears to have been caused by the interaction of hypomorphic mutations in RNF216 and OTUD4 ."
23656588
OTUD4 affects UBC
3 |
UBC binds OTUD4. 3 / 3
3 |
biogrid
No evidence text available
28190767
biogrid
No evidence text available
25944111
biogrid
No evidence text available
23827681
OTUD4 affects SMN2
| 3
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
SMN2 binds OTUD4. 1 / 1
| 1
sparser
"Because OTUD4 interacted with SMN1 in co-IPs and SMN1 has been well characterized in neuronal RNP granules ( xref ; xref ), we co-expressed mOrange2–OTUD4 with neonGreen–SMN1 in hippocampal neurons for live-cell imaging."
31138677
OTUD4 affects NFkappaB
| 3
OTUD4 activates NFkappaB.
| 2
OTUD4 activates NFkappaB. 2 / 2
| 2
reach
"Knockout or knockdown of OTUD4 impairs RNA virus triggered activation of IRF3 and NF-kappaB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo."
30410068
reach
"Additionally, the knockout of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-kB and the expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo (66) ."
34707613
OTUD4 inhibits NFkappaB.
| 1
OTUD4 inhibits NFkappaB. 1 / 1
| 1
reach
"Additionally, the liver inflammatory response and tissue damage were ameliorated in mice overexpressing OTUD4.Taken together, these results show that OTUD4 can negatively regulate NF-kappaB activation by suppressing the K63 linked ubiquitination of TRAF6, thus alleviating hepatic ischemia-reperfusion injury."
31964525
OTUD4 affects FlaG
| 3
OTUD4 binds FlaG. 3 / 3
| 3
sparser
"These RNA-IPs showed a clear enrichment of RNA with FLAG–OTUD4 compared to that seen in control IPs ( xref C)."
31138677
sparser
"We applied UV crosslinking to stabilize RNA–protein interactions, immunoprecipitated FLAG–OTUD4 and subsequently isolated the co-precipitated RNA from OTUD4 or control beads."
31138677
sparser
"To elucidate whether the OTUD4 granules also contained RNA, we carried out in situ hybridization with a fluorescently (Cy3)-labeled oligo(dT) probe to detect poly(A)-tails of mRNAs ( xref B), together with immunostaining for FLAG–OTUD4."
31138677
OTUD4 affects EGFP
| 3
OTUD4 binds EGFP. 3 / 3
| 3
sparser
"Primary rat hippocampal neurons were transfected with EGFP–OTUD4 and imaged by confocal microscopy."
31138677
sparser
"EGFP–OTUD4 resided not only in the cell body but also showed prominent granular structures in proximal and distal parts of axons and in dendrites ( xref A)."
31138677
sparser
"We stained EGFP–OTUD4-expressing neurons with an anti-FMRP antibody to look for colocalization of EGFP–OTUD4 and FMRP ( xref A)."
31138677
OTUD4 affects ADSL
| 3
OTUD4 decreases the amount of ADSL. 3 / 3
| 3
reach
"Mechanistically, knockout of OTUD4 results in hyper K63-linked ubiquitination of MyD88 and increases the activation of NF-κB and MAPKs to promote the expression of AMPs."
37193092
reach
"Here, we report that the ovarian tumor family deubiquitinase 4 (OTUD4) in Paneth cells restricts the expression of AMPs and thereby promotes experimental colitis and bacterial infection."
37193092
reach
"Knockout of OTUD4 promotes the expression of AMPs in intestinal organoids after stimulation with lipopolysaccharide (LPS) or peptidoglycan (PGN) and in the intestinal epithelial cells (IECs) of mice after DSS treatment or Salmonella typhimurium ( S ."
37193092
MAVS affects OTUD4
| 1 2
MAVS binds OTUD4.
| 2
OTUD4 binds MAVS. 2 / 2
| 2
sparser
"The deubiquitinase OTUD4 interacts with MAVS to remove its K48-linked polyubiquitin chains and thereby maintains MAVS stability and promotes innate antiviral signaling."
34707613
sparser
"Viral infection leads to the IRF3/7-dependent upregulation of OTUD4 which interacts with MAVS to remove K48-linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling."
30410068
MAVS activates OTUD4.
| 1
MAVS activates OTUD4. 1 / 1
| 1
reach
"OTUD4 is induced by virus infection and targets MAVS ubiquitination, triggeringIRF3 and NF-κB signaling to sustain antiviral responses [85]."
32650621
FlaG affects OTUD4
| 3
OTUD4 binds FlaG. 3 / 3
| 3
sparser
"These RNA-IPs showed a clear enrichment of RNA with FLAG–OTUD4 compared to that seen in control IPs ( xref C)."
31138677
sparser
"We applied UV crosslinking to stabilize RNA–protein interactions, immunoprecipitated FLAG–OTUD4 and subsequently isolated the co-precipitated RNA from OTUD4 or control beads."
31138677
sparser
"To elucidate whether the OTUD4 granules also contained RNA, we carried out in situ hybridization with a fluorescently (Cy3)-labeled oligo(dT) probe to detect poly(A)-tails of mRNAs ( xref B), together with immunostaining for FLAG–OTUD4."
31138677
EGFP affects OTUD4
| 3
OTUD4 binds EGFP. 3 / 3
| 3
sparser
"Primary rat hippocampal neurons were transfected with EGFP–OTUD4 and imaged by confocal microscopy."
31138677
sparser
"EGFP–OTUD4 resided not only in the cell body but also showed prominent granular structures in proximal and distal parts of axons and in dendrites ( xref A)."
31138677
sparser
"We stained EGFP–OTUD4-expressing neurons with an anti-FMRP antibody to look for colocalization of EGFP–OTUD4 and FMRP ( xref A)."
31138677
Vasotocin affects OTUD4
| 1 1
Vasotocin inhibits OTUD4. 2 / 2
| 1 1
reach
"XREF_FIG d, AVT also decreases Otud4, Otud5 and Otud7b in addition to Otub1 and c-Maf."
33627137
eidos
"As shown in Fig. 5d , AVT also decreases Otud4 , Otud5 and Otud7b in addition to Otub1 / c-Maf ."
33627137
Trichostatin A affects OTUD4
2 |
Trichostatin A decreases the amount of OTUD4. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
MiR-103a-3p affects OTUD4
| 1 1
MiR-103a-3p inhibits OTUD4.
| 1
MiR-103a-3p inhibits OTUD4. 1 / 1
| 1
eidos
"Increased miR-103a-3p expression leads to downregulation OTUD4 to stimulate ZIKV replication through the activation of p38 MAPK signaling pathway ."
35317262
MiR-103a-3p activates OTUD4.
| 1
MiR-103a-3p activates OTUD4. 1 / 1
| 1
reach
"Zika virus infection induced the expression of miR-103a-3p, which subsequently activated p38 MAPK signaling pathway by targeting OTUD4 to facilitate ZIKV replication."
35317262
Hsa-miR-6875-3p affects OTUD4
2 |
Hsa-miR-6875-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6809-3p affects OTUD4
2 |
Hsa-miR-6809-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6516-5p affects OTUD4
2 |
Hsa-miR-6516-5p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-5571-5p affects OTUD4
2 |
Hsa-miR-5571-5p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-513a-5p affects OTUD4
2 |
Hsa-miR-513a-5p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-498 affects OTUD4
2 |
Hsa-miR-498 decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4778-3p affects OTUD4
2 |
Hsa-miR-4778-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4760-3p affects OTUD4
2 |
Hsa-miR-4760-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4753-3p affects OTUD4
2 |
Hsa-miR-4753-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4714-3p affects OTUD4
2 |
Hsa-miR-4714-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-455-3p affects OTUD4
2 |
Hsa-miR-455-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23592263
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4282 affects OTUD4
2 |
Hsa-miR-4282 decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4272 affects OTUD4
2 |
Hsa-miR-4272 decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-30b-5p affects OTUD4
2 |
Hsa-miR-30b-5p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22473208
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-27b-3p affects OTUD4
2 |
Hsa-miR-27b-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-27a-3p affects OTUD4
2 |
Hsa-miR-27a-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-19b-3p affects OTUD4
2 |
Hsa-miR-19b-3p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-130b-5p affects OTUD4
2 |
Hsa-miR-130b-5p decreases the amount of OTUD4. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23446348
DsDNA affects OTUD4
| 2
OTUD4 binds dsDNA. 2 / 2
| 2
reach
"Structure based mutagenesis of OB1 N-terminal residues (Lys48 and Lys53) for minor groove interaction and of OB2 residues (Arg224) for major groove recognition showed that these positively charged residues are crucial for HIN1 and dsDNA interaction (XREF_FIG, XREF_SUPPLEMENTARY)."
23850291
reach
"Crystal structures of the p202 HIN1 and dsDNA complexes show that the two OB folds are very similar to those of AIM2, but that the dsDNA binds p202 HIN1 at an almost opposite surface compared with that used in AIM2 HIN (XREF_FIG) [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25881155
WBP2NL affects OTUD4
2 |
OTUD4 binds WBP2NL. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
TRAF1 affects OTUD4
2 |
TRAF1 binds OTUD4. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
25996949
Smoke affects OTUD4
2 |
Smoke increases the amount of OTUD4.
1 |
Smoke increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26468118
Smoke decreases the amount of OTUD4.
1 |
Smoke decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26468118
SMN2 affects ELAVL2
| 2
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
RARB affects OTUD4
| 2
RARB activates OTUD4. 2 / 2
| 2
reach
"RARbeta causes cell cycle arrest, growth inhibition and induction of apoptosis, and HIN-1 in cycle reentry [XREF_BIBR]."
28475137
reach
"RARbeta causes cell cycle arrest, growth inhibition and induction of apoptosis, and HIN-1 in cycle reentry [XREF_BIBR]."
23826992
OTUD4 inhibits inflammatory response. 2 / 2
| 2
reach
"The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection."
37193092
reach
"OTUD4 has been shown to deubiquitinate K63-linked chains of 274 myeoloid differentiation primary response 88 (MYD88) and to downregulate NF-kB-dependent 275 inflammation."
| DOI
OTUD4 affects dsDNA
| 2
OTUD4 binds dsDNA. 2 / 2
| 2
reach
"Structure based mutagenesis of OB1 N-terminal residues (Lys48 and Lys53) for minor groove interaction and of OB2 residues (Arg224) for major groove recognition showed that these positively charged residues are crucial for HIN1 and dsDNA interaction (XREF_FIG, XREF_SUPPLEMENTARY)."
23850291
reach
"Crystal structures of the p202 HIN1 and dsDNA complexes show that the two OB folds are very similar to those of AIM2, but that the dsDNA binds p202 HIN1 at an almost opposite surface compared with that used in AIM2 HIN (XREF_FIG) [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25881155
OTUD4 affects cisplatin
| 2
OTUD4 activates cisplatin. 2 / 2
| 2
reach
"In this study, overexpression of HIN-1 enhanced ES2 cell sensitivity to paclitaxel and cisplatin through inhibiting cell growth and enhancing apoptosis."
22871047
reach
"Furthermore, overexpression of HIN-1 enhanced ES2 cell sensitivity to paclitaxel and cisplatin through significantly inhibiting cell growth and increasing early and late apoptosis, which supports the results of HIN-1 promoter methylation with downregulation of HIN-1 expression causing poor survival outcomes in OCCA patients."
22871047
OTUD4 affects apoptotic process
| 2
OTUD4 activates apoptotic process. 2 / 2
| 2
reach
"Overexpression of OTUD4 increases radiosensitivity of NSCLC cells exhibiting as impaired clonogenic formation ability, enhanced cell cycle arrest and increased cell apoptosis."
31011293
reach
"Expression of HIN-1 in synchronized cells inhibits cell cycle re-entry and the phosphorylation of the retinoblastoma protein (Rb), while in exponentially growing cells HIN-1 induces apoptosis without apparent cell cycle arrest or an effect on Rb phosphorylation."
| PMC
OTUD4 affects WBP2NL
2 |
OTUD4 binds WBP2NL. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
OTUD4 affects TRAF1
2 |
TRAF1 binds OTUD4. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
25996949
OTUD4 affects RB1
| 2
Modified OTUD4 leads to the dephosphorylation of RB1. 2 / 2
| 2
reach
"Expression of HIN-1 in synchronized cells inhibits cell cycle re-entry and the phosphorylation of the retinoblastoma protein (Rb), while in exponentially growing cells HIN-1 induces apoptosis without apparent cell cycle arrest or an effect on Rb phosphorylation."
| PMC
reach
"Expression of HIN-1 in synchronized cells inhibits cell cycle re-entry and the phosphorylation of the retinoblastoma protein (Rb), while in exponentially growing cells HIN-1 induces apoptosis without apparent cell cycle arrest or an effect on Rb phosphorylation."
| PMC
OTUD4 affects OTUD4
| 2
OTUD4 decreases the amount of OTUD4.
| 1
Methylated OTUD4 decreases the amount of OTUD4. 1 / 1
| 1
reach
"We also identified that methylation of HIN-1 downregulated the expression of HIN-1 in OCCA cell lines and cancerous tissues according to RT-PCR, Western blot, and IHC analyses."
22871047
OTUD4 activates OTUD4.
| 1
OTUD4 activates OTUD4. 1 / 1
| 1
reach
"To investigate the role of WRKY46 in plant defense, we analyzed expression of a luciferase (LUC) reporter driven by a routinely used W-box-containing defense related promoter, NDR1 and HIN1 like 10 (NHL10), in Arabidopsis protoplasts co-expressing either different variants of WRKY46 or CFP (as a control for expression of a defense unrelated protein)."
26870073
reach
"Furthermore, overexpression of OTUD4 could inhibit tumor cell proliferation, migration and invasion of breast, liver and lung cancer cells through inhibiting the AKT signaling pathway."
32184655
reach
"As further evidence that HIN-1 can influence invasive behavior, expression of HIN-1 markedly inhibited the invasion and migration of breast cancer cell lines in Boyden chamber assays."
| PMC
OTUD4 affects NIBAN2
| 1 1
OTUD4 binds NIBAN2. 1 / 1
| 1
reach
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
OTUD4 binds NIBAN2 and DNMT1. 1 / 1
| 1
sparser
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
OTUD4 affects Interferon
| 2
OTUD4 increases the amount of Interferon. 2 / 2
| 2
reach
"[178] This is supported by the observation that knockout or knockdown of OTUD4 impairs the RNA virus triggered expression of type I interferon and enhances VSV replication, both in vitro and in vivo."
33511009
reach
"Therefore, OTUD4 could enhance type I IFN expression during HSV-1 infection, and this function appeared to be blocked by ICP0-dependent processes.After confirming that ICP0 was important for HSV-1 lytic infection in neuronal cells, we combined quantitative interactome and ubiquitinome approaches to identify targets of ICP0 followed by validation of the interaction and ubiquitination events in Neuro-2a cells."
35516420
OTUD4 affects IgG
| 2
OTUD4 activates IgG. 2 / 2
| 2
reach
"In coculture experiments, sorted pTFH cells supported HIN1 stimulated IgG production by autologous B cells only in vaccine responders."
22692510
reach
"In coculture experiments, pTfh supported HIN1 stimulated IgG production by autologous B cells."
29109730
OTUD4 affects IRF3
| 2
OTUD4 activates IRF3. 2 / 2
| 2
reach
"Knockout or knockdown of OTUD4 impairs RNA virus triggered activation of IRF3 and NF-kappaB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo."
30410068
reach
"Additionally, the knockout of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-kB and the expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo (66) ."
34707613
OTUD4 affects IGF2BP3
| 2
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
TIAL1 binds OTUD4 and IGF2BP3. 1 / 1
| 1
sparser
"In contrast, the interaction of IGF2BP3 and TIAR with OTUD4 was even enhanced after RNase treatment ( xref E,G)."
31138677
OTUD4 affects IFNA
| 2
OTUD4 increases the amount of IFNA. 2 / 2
| 2
reach
"In concordance with the luciferase results, quantification of endogenous IFN-α mRNA showed that induction of IFN-α expression by KOS but not 7134 virus was obvious at an MOI of 2, and overexpressed OTUD4 significantly increased IFN-α mRNA levels in 7134 but not KOS infected cells (Figure 6F)."
35516420
reach
"At a lower MOI of 0.5, where induction of IFN-α expression was no longer detectable even in KOS infected cells, overexpressed OTUD4 significantly increased IFN-α mRNA levels in 7134 but not KOS virus infected cells."
35516420
OTUD4 affects GST
| 2
GST binds OTUD4. 2 / 2
| 2
sparser
"GST–OTUD4 or GST protein alone, as a control, were coupled to glutathione–Sepharose beads and incubated with biotinylated RNA or without RNA."
31138677
sparser
"The fluorescence intensity in the presence of biotinylated RNA was more than 10-fold higher for GST–OTUD4 compared to the GST control, indicating that OTUD4 was able to bind RNA under these conditions ( xref B)."
31138677
OTUD4 affects ESS2
| 2
OTUD4 activates ESS2. 2 / 2
| 2
reach
"Furthermore, overexpression of HIN-1 enhanced ES2 cell sensitivity to paclitaxel and cisplatin through significantly inhibiting cell growth and increasing early and late apoptosis, which supports the results of HIN-1 promoter methylation with downregulation of HIN-1 expression causing poor survival outcomes in OCCA patients."
22871047
reach
"In this study, overexpression of HIN-1 enhanced ES2 cell sensitivity to paclitaxel and cisplatin through inhibiting cell growth and enhancing apoptosis."
22871047
OTUD4 affects ELAVL2
| 2
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
OTUD4 affects DNMT1
| 1 1
OTUD4 binds DNMT1. 1 / 1
| 1
reach
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
OTUD4 binds NIBAN2 and DNMT1. 1 / 1
| 1
sparser
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
OTUD4 affects ALKBH2
1 | 1
OTUD4 deubiquitinates ALKBH2.
| 1
OTUD4 deubiquitinates ALKBH2. 1 / 1
| 1
reach
"Besides USP11, OTUD4 is another USP7 partner that deubiquitinates DNA demethylases ALKBH2 and ALKBH3 [118]."
33991872
OTUD4 binds ALKBH2.
1 |
OTUD4 binds ALKBH2. 1 / 1
1 |
biogrid
No evidence text available
25944111
NIBAN2 affects OTUD4
| 1 1
OTUD4 binds NIBAN2. 1 / 1
| 1
reach
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
OTUD4 binds NIBAN2 and DNMT1. 1 / 1
| 1
sparser
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
IRF3/7 affects OTUD4
| 2
IRF3/7 activates OTUD4. 2 / 2
| 2
reach
"Viral infection leads to the IRF3/7 dependent upregulation of OTUD4 which interacts with MAVS to remove K48 linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling."
30410068
reach
"Degradative ubiquitination is counteracted by DUBs, as shown for ovarian tumor family deubiquitinase 4 (OTUD4), whose expression is increased by IRF3/7 in a positive-feedback loop (Liuyu et al., 2019)."
32117959
IGF2BP3 affects OTUD4
| 2
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
TIAL1 binds OTUD4 and IGF2BP3. 1 / 1
| 1
sparser
"In contrast, the interaction of IGF2BP3 and TIAR with OTUD4 was even enhanced after RNase treatment ( xref E,G)."
31138677
Harpin affects OTUD4
| 2
Harpin activates OTUD4. 2 / 2
| 2
reach
"Transcripts for several well studied pathogen induced genes were found to be up-regulated these include : a chitinase (AK099355), a chitinase precursor Oschib (AK100973), an aspartic protease Os11g0183900 (AK061884) as well as two Harpin induced 1 (Hin1) domain containing proteins (AK068115, AK108457)."
22289642
reach
"This contrasts with findings in tobacco, where Harpin triggered the PR gene HIN1 through calcium independent MAPK signalling XREF_BIBR."
22792328
GST affects OTUD4
| 2
GST binds OTUD4. 2 / 2
| 2
sparser
"GST–OTUD4 or GST protein alone, as a control, were coupled to glutathione–Sepharose beads and incubated with biotinylated RNA or without RNA."
31138677
sparser
"The fluorescence intensity in the presence of biotinylated RNA was more than 10-fold higher for GST–OTUD4 compared to the GST control, indicating that OTUD4 was able to bind RNA under these conditions ( xref B)."
31138677
ELAVL2 affects SMN2
| 2
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
DNMT1 affects OTUD4
| 1 1
OTUD4 binds DNMT1. 1 / 1
| 1
reach
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
OTUD4 binds NIBAN2 and DNMT1. 1 / 1
| 1
sparser
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
Coal affects OTUD4
2 |
Coal increases the amount of OTUD4.
1 |
Coal increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26468118
Coal decreases the amount of OTUD4.
1 |
Coal decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26468118
Air Pollutants affects OTUD4
2 |
Air Pollutants increases the amount of OTUD4.
1 |
Air Pollutants increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26468118
Air Pollutants decreases the amount of OTUD4.
1 |
Air Pollutants decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26468118
17alpha-ethynylestradiol increases the amount of OTUD4.
1 |
17alpha-ethynylestradiol increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
29097150
17alpha-ethynylestradiol decreases the amount of OTUD4.
1 |
17alpha-ethynylestradiol decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
23129252
Α-GalCer affects OTUD4
| 1
Α-GalCer activates OTUD4. 1 / 1
| 1
reach
"The intranasal administration of NKT cell ligand ameliorated H1N1 IAV infection in piglets [51] , while the adjuvant effect of α-GalCer potentiated the immune response of the inactivated HIN1 influenza virus in pigs [52] ."
34579186
Vorinostat affects OTUD4
1 |
Vorinostat decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
27188386
Vinclozolin affects OTUD4
1 |
Vinclozolin decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
18042343
Valproic acid affects OTUD4
| 1
Valproic acid increases the amount of OTUD4. 1 / 1
| 1
reach
"In this study we demonstrated that the expression of HIN1 was upregulated by VPA and is associated with modulation of NB phenotype."
22863973
Troglitazone affects OTUD4
1 |
Troglitazone decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
28973697
ctd
No evidence text available
26179874
TriggeringIRF3 affects OTUD4
| 1
TriggeringIRF3 activates OTUD4. 1 / 1
| 1
reach
"OTUD4 is induced by virus infection and targets MAVS ubiquitination, triggeringIRF3 and NF-κB signaling to sustain antiviral responses [85]."
32650621
Torcetrapib affects OTUD4
1 |
Torcetrapib increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
23228038
Thioacetamide affects OTUD4
1 |
Thioacetamide increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
23411599
Thimerosal affects OTUD4
1 |
Thimerosal decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
27188386
Tetrachloromethane increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
31150632
Targets ubiquitination affects OTUD4
| 1
Targets ubiquitination activates OTUD4. 1 / 1
| 1
eidos
"OTUD4 is induced by virus infection and targets MAVS ubiquitination , triggeringIRF3 and NF-kappaB signaling to sustain antiviral responses [ 85 ] ."
32650621
Tamoxifen affects OTUD4
| 1
Tamoxifen leads to the methylation of OTUD4. 1 / 1
| 1
reach
"Tamoxifen did not modulate methylation of CCND2, HIN1, CST6, or RAR-beta2, but the mean difference for the sum of APC and RASSF1A methylation fractions between post-treatment and baseline samples was +7.1% for placebo subjects and -3.5% for tamoxifen subjects (P = 0.021)."
21778330
Succimer affects OTUD4
1 |
Succimer decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26378955
Spermine affects OTUD4
| 1
Spermine activates OTUD4. 1 / 1
| 1
reach
"Gene expression analysis in different plant species showed that Spm mediates the induction of several defense genes, such as members of the hairpin induced 1 (HIN1) family, proteinase inhibitors, the transcription repressor ZFT1, and HR associated factors."
24672533
Sodium dichromate affects OTUD4
1 |
Sodium dichromate increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25993096
Sodium arsenate affects OTUD4
1 |
Sodium arsenate increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
21795629
Potassium dichromate decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
23608068
reach
"Overexpression of CC A 309 and ANL620, but not CC A 10-1, resulted in significantly higher transcription of several genes, including the HR cell death marker gene Harpin induced 1 (Hin1), a transcription factor for physiological substrates of mitogen activated protein kinases, WRKY8, a cytochrome P450 involved in sesquiterpene phytoalexin biosynthesis, CYP71D20, and Pathogenesis related gene 1 (PR1) (Gopalan et al., 1996; Glazebrook, 2005; Ishihama et al., 2011; Weitzel & Simonsen, 2015)."
32810286
Phorbol 13-acetate 12-myristate increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25613284
Pentanal affects OTUD4
1 |
Pentanal decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26079696
Paracetamol affects OTUD4
1 |
Paracetamol decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
22230336
PTfh affects OTUD4
| 1
PTfh activates OTUD4. 1 / 1
| 1
reach
"In coculture experiments, pTfh supported HIN1 stimulated IgG production by autologous B cells."
29109730
PHIR11 affects OTUD4
| 1
PHIR11 activates OTUD4. 1 / 1
| 1
reach
"When inoculated to tobacco ' Bright Yellow ', P fluorescens (pHIR11) induces the HR and expression of four tobacco defense response genes : HIN1, RbohB, PAL, and PR1."
16570663
P202 affects OTUD4
| 1
P202 activates OTUD4. 1 / 1
| 1
reach
"As expected from deletion of HIN2 in reducing p202 and DNA interaction, we found that full-length p202 exhibits ~ 10-fold and ~ 5-fold enhanced affinity for DNA relative to p202 HIN1 and AIM2 HIN respectively (XREF_FIG), suggesting that full-length p202 may compete favorably with AIM2 for limited dsDNA in the cytosol."
23850291
Over-expression miR-103a-3p affects OTUD4
| 1
Over-expression miR-103a-3p inhibits OTUD4. 1 / 1
| 1
eidos
"By qRT-PCR and Western blot , we found OTUD4 expression was significantly downregulated by over-expression of miR-103a-3p compared to negative control ( Figure 4B ) ."
35317262
MiR-494-3p affects OTUD4
| 1
OTUD4 binds miR-494-3p. 1 / 1
| 1
reach
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
MiR-29b-1-5p affects OTUD4
| 1
Modified miR-29b-1-5p increases the amount of OTUD4. 1 / 1
| 1
reach
"Furthermore, miR-29b-1-5p overexpression induces both inhibition of DNA N-methyltransferases (DNMT1, DNMT3A, and DNMT3B) expression and re-expression of HIN1, RASSF1A and CCND2."
31313842
Magnetite nanoparticle decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26378955
Leflunomide affects OTUD4
1 |
Leflunomide increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
19751817
Jinfukang affects OTUD4
1 |
Jinfukang decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
27392435
Ionomycin affects OTUD4
1 |
Ionomycin increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25613284
Hypochlorous acid affects OTUD4
1 |
Hypochlorous acid increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
19376150
Hsa-miR-93-5p affects OTUD4
1 |
Hsa-miR-93-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-767-5p affects OTUD4
1 |
Hsa-miR-767-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-766-5p affects OTUD4
1 |
Hsa-miR-766-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-744-5p affects OTUD4
1 |
Hsa-miR-744-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-7111-5p affects OTUD4
1 |
Hsa-miR-7111-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-7106-5p affects OTUD4
1 |
Hsa-miR-7106-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6887-5p affects OTUD4
1 |
Hsa-miR-6887-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6885-3p affects OTUD4
1 |
Hsa-miR-6885-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-6871-3p affects OTUD4
1 |
Hsa-miR-6871-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6870-5p affects OTUD4
1 |
Hsa-miR-6870-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6859-5p affects OTUD4
1 |
Hsa-miR-6859-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6825-5p affects OTUD4
1 |
Hsa-miR-6825-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6807-5p affects OTUD4
1 |
Hsa-miR-6807-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-6795-5p affects OTUD4
1 |
Hsa-miR-6795-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6751-3p affects OTUD4
1 |
Hsa-miR-6751-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-675-5p affects OTUD4
1 |
Hsa-miR-675-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6513-3p affects OTUD4
1 |
Hsa-miR-6513-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-570-3p affects OTUD4
1 |
Hsa-miR-570-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-5698 affects OTUD4
1 |
Hsa-miR-5698 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-5682 affects OTUD4
1 |
Hsa-miR-5682 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-5582-3p affects OTUD4
1 |
Hsa-miR-5582-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548x-3p affects OTUD4
1 |
Hsa-miR-548x-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548j-3p affects OTUD4
1 |
Hsa-miR-548j-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548aq-3p affects OTUD4
1 |
Hsa-miR-548aq-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548am-3p affects OTUD4
1 |
Hsa-miR-548am-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548aj-3p affects OTUD4
1 |
Hsa-miR-548aj-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548ah-3p affects OTUD4
1 |
Hsa-miR-548ah-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548ae-3p affects OTUD4
1 |
Hsa-miR-548ae-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-526b-3p affects OTUD4
1 |
Hsa-miR-526b-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-524-5p affects OTUD4
1 |
Hsa-miR-524-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-520d-5p affects OTUD4
1 |
Hsa-miR-520d-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-519d-3p affects OTUD4
1 |
Hsa-miR-519d-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-486-3p affects OTUD4
1 |
Hsa-miR-486-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4796-3p affects OTUD4
1 |
Hsa-miR-4796-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4749-5p affects OTUD4
1 |
Hsa-miR-4749-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4723-5p affects OTUD4
1 |
Hsa-miR-4723-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4709-3p affects OTUD4
1 |
Hsa-miR-4709-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4706 affects OTUD4
1 |
Hsa-miR-4706 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4699-5p affects OTUD4
1 |
Hsa-miR-4699-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4466 affects OTUD4
1 |
Hsa-miR-4466 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4465 affects OTUD4
1 |
Hsa-miR-4465 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-4255 affects OTUD4
1 |
Hsa-miR-4255 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3916 affects OTUD4
1 |
Hsa-miR-3916 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3675-5p affects OTUD4
1 |
Hsa-miR-3675-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3662 affects OTUD4
1 |
Hsa-miR-3662 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3646 affects OTUD4
1 |
Hsa-miR-3646 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3591-5p affects OTUD4
1 |
Hsa-miR-3591-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3163 affects OTUD4
1 |
Hsa-miR-3163 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3125 affects OTUD4
1 |
Hsa-miR-3125 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-31-5p affects OTUD4
1 |
Hsa-miR-31-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-30e-5p affects OTUD4
1 |
Hsa-miR-30e-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-30d-5p affects OTUD4
1 |
Hsa-miR-30d-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-30c-5p affects OTUD4
1 |
Hsa-miR-30c-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-30a-5p affects OTUD4
1 |
Hsa-miR-30a-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-29c-3p affects OTUD4
1 |
Hsa-miR-29c-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-29b-3p affects OTUD4
1 |
Hsa-miR-29b-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-29a-3p affects OTUD4
1 |
Hsa-miR-29a-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-26b-5p affects OTUD4
1 |
Hsa-miR-26b-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-26a-5p affects OTUD4
1 |
Hsa-miR-26a-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-2681-5p affects OTUD4
1 |
Hsa-miR-2681-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-219b-3p affects OTUD4
1 |
Hsa-miR-219b-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-219a-2-3p affects OTUD4
1 |
Hsa-miR-219a-2-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-219a-1-3p affects OTUD4
1 |
Hsa-miR-219a-1-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-20b-5p affects OTUD4
1 |
Hsa-miR-20b-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-20a-5p affects OTUD4
1 |
Hsa-miR-20a-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-19a-3p affects OTUD4
1 |
Hsa-miR-19a-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-18a-3p affects OTUD4
1 |
Hsa-miR-18a-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-183-5p affects OTUD4
1 |
Hsa-miR-183-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-17-5p affects OTUD4
1 |
Hsa-miR-17-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-152-3p affects OTUD4
1 |
Hsa-miR-152-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-148b-3p affects OTUD4
1 |
Hsa-miR-148b-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-148a-3p affects OTUD4
1 |
Hsa-miR-148a-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-142-3p affects OTUD4
1 |
Hsa-miR-142-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-130b-3p affects OTUD4
1 |
Hsa-miR-130b-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-1297 affects OTUD4
1 |
Hsa-miR-1297 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-1256 affects OTUD4
1 |
Hsa-miR-1256 decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-1199-5p affects OTUD4
1 |
Hsa-miR-1199-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-106b-5p affects OTUD4
1 |
Hsa-miR-106b-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-106a-5p affects OTUD4
1 |
Hsa-miR-106a-5p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-101-3p affects OTUD4
1 |
Hsa-miR-101-3p decreases the amount of OTUD4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hrp affects OTUD4
| 1
Hrp activates OTUD4. 1 / 1
| 1
reach
"Hrp gene dependent induction of hin1 : a plant gene activated rapidly by both harpins and the avrPto gene mediated signal."
8893538
Hrp mutants affects OTUD4
| 1
Hrp mutants activates OTUD4. 1 / 1
| 1
reach
"P. fluorescens (a saprophyte) or hrp mutants defective in the Hrp secretion pathway did not induce hin1 significantly."
8893538
Harpin protein affects OTUD4
| 1
Harpin protein activates OTUD4. 1 / 1
| 1
reach
"HIN1 is induced by harpin protein and plays an important role in various plant defense responses."
36352857
Harpin binding site affects OTUD4
| 1
Harpin binding site activates OTUD4. 1 / 1
| 1
reach
"A harpin binding site in tobacco plasma membranes mediates activation of the pathogenesis related gene HIN1 independent of extracellular calcium but dependent on mitogen activated protein kinase activity."
11340183
Geldanamycin affects OTUD4
1 |
Geldanamycin increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26705709
Enzyme inhibitor affects OTUD4
1 |
Enzyme inhibitor inhibits OTUD4. 1 / 1
1 |
ctd
No evidence text available
23301498
Dorsomorphin affects OTUD4
1 |
Dorsomorphin decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
27188386
Dioxygen affects OTUD4
| 1
Dioxygen increases the amount of OTUD4. 1 / 1
| 1
sparser
"CmCP-treated plant leaves showed symptoms of hypersensitive response including electrolyte leakage, reactive oxygen species generation and overexpression of defense-related genes PR-1 , PAD3 , ERF1 , HSR203J , and HIN1 ."
32849428
Cupric oxide affects OTUD4
1 |
Cupric oxide decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
22077320
Copper(II) sulfate increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
19549813
Cobalt dichloride affects OTUD4
1 |
Cobalt dichloride increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
24386269
Butanal affects OTUD4
1 |
Butanal decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
26079696
Benzo[a]pyrene diol epoxide I decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
19150397
Aflatoxin B1 affects OTUD4
1 |
Aflatoxin B1 methylates OTUD4. 1 / 1
1 |
ctd
No evidence text available
27153756
Acetamide affects OTUD4
1 |
Acetamide decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
31881176
XopB affects OTUD4
| 1
XopB inhibits OTUD4. 1 / 1
| 1
reach
"XREF_BIBR showed recently that XopB suppresses flg22 mediated induction of the NHL10 (NDR1 and Hin1 like 10) promoter fused to luciferase which served as a reporter for basal defense."
23272161
XPO1 affects OTUD4
1 |
XPO1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
26673895
Virus Diseases affects OTUD4
| 1
eidos
"OTUD4 is induced by virus infection and targets MAVS ubiquitination , triggeringIRF3 and NF-kappaB signaling to sustain antiviral responses [ 85 ] ."
32650621
VTN affects OTUD4
1 |
VTN binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
28514442
US9 affects OTUD4
1 |
OTUD4 binds US9. 1 / 1
1 |
virhostnet
No evidence text available
31873071
US22 affects OTUD4
1 |
OTUD4 binds US22. 1 / 1
1 |
virhostnet
No evidence text available
31873071
UDP1 affects OTUD4
| 1
UDP1 activates OTUD4. 1 / 1
| 1
reach
"Several defense genes, including WRKY28 and PTI5 of PAMP-triggered immunity (PTI), UDP and UDP1 of effector-triggered immunity (ETI), Hin1 and HSR203J of HR, PR1a of systemic acquired resistance (SAR) and the SAR related gene NPR1 were all up-regulated in transgenic tomato leaves overexpressing BvEP."
36523612
UDP affects OTUD4
| 1
UDP activates OTUD4. 1 / 1
| 1
reach
"Several defense genes, including WRKY28 and PTI5 of PAMP-triggered immunity (PTI), UDP and UDP1 of effector-triggered immunity (ETI), Hin1 and HSR203J of HR, PR1a of systemic acquired resistance (SAR) and the SAR related gene NPR1 were all up-regulated in transgenic tomato leaves overexpressing BvEP."
36523612
Toll Like Receptor affects OTUD4
| 1
OTUD4 binds Toll Like Receptor. 1 / 1
| 1
sparser
"Our mass spectrometry results suggested that OTUD4 is associated with the Toll-like receptor (TLR) associated factor MyD88 in cytosol extracts ( xref )."
29395066
TUBA1A affects OTUD4
1 |
TUBA1A binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19615732
TSPYL6 affects OTUD4
1 |
TSPYL6 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
28514442
TPTE2 affects OTUD4
1 |
TPTE2 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
27880917
TIAL1 affects OTUD4
| 1
TIAL1 binds OTUD4 and IGF2BP3. 1 / 1
| 1
sparser
"In contrast, the interaction of IGF2BP3 and TIAR with OTUD4 was even enhanced after RNase treatment ( xref E,G)."
31138677
TGFB affects OTUD4
| 1
TGFB binds OTUD4. 1 / 1
| 1
sparser
"We therefore sought to validate whether or not OTUD4 interacted with components of the TGFβ receptor complex."
32973272
TCF4 affects OTUD4
1 |
TCF4 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
25416956
virhostnet
No evidence text available
30550790
Samsun nn affects OTUD4
| 1
Samsun nn increases the amount of OTUD4. 1 / 1
| 1
reach
"Transcription of HIN1 was greatly upregulated by inoculation of recombinant TMVs in both Samsun nn and Samsun NN at two different temperatures (25degreesC and 33degreesC) (XREF_FIG)."
21124743
STAT1 affects OTUD4
1 |
STAT1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
25416956
SMN2 affects MYC
| 1
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
SMN2 affects G3BP1
| 1
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
SERPINB6 affects OTUD4
| 1
SERPINB6 activates OTUD4. 1 / 1
| 1
reach
"Several defense genes, including WRKY28 and PTI5 of PAMP-triggered immunity (PTI), UDP and UDP1 of effector-triggered immunity (ETI), Hin1 and HSR203J of HR, PR1a of systemic acquired resistance (SAR) and the SAR related gene NPR1 were all up-regulated in transgenic tomato leaves overexpressing BvEP."
36523612
RUNX1T1 affects OTUD4
1 |
RUNX1T1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
17353931
RPTN affects OTUD4
1 |
OTUD4 binds RPTN. 1 / 1
1 |
biogrid
No evidence text available
19615732
REL affects OTUD4
1 |
OTUD4 binds REL. 1 / 1
1 |
biogrid
No evidence text available
25416956
RC3H1 affects OTUD4
1 |
OTUD4 binds RC3H1. 1 / 1
1 |
biogrid
No evidence text available
26170170
RBP4 affects OTUD4
| 1
OTUD4 binds RBP4. 1 / 1
| 1
sparser
"Strikingly, OTUD4 interacted with many RBPs and was able to interact with RNA itself."
31138677
RBFOX2 affects OTUD4
1 |
OTUD4 binds RBFOX2. 1 / 1
1 |
biogrid
No evidence text available
26186194
Plant Extracts affects OTUD4
1 |
Plant Extracts increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
23557933
PRPF4 affects OTUD4
1 |
PRPF4 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
26496610
PCB 180 affects OTUD4
1 |
PCB 180 increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25510870
PARP11 affects OTUD4
1 |
PARP11 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19615732
P.s. pv affects OTUD4
| 1
P.s. pv activates OTUD4. 1 / 1
| 1
reach
"Induction of hin1 by P.s. pv."
8893538
OTUD7A affects OTUD4
| 1
OTUD7A binds OTUD4. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD6B affects OTUD4
| 1
OTUD6B binds OTUD4. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD4 affects type I interferons
| 1
OTUD4 increases the amount of type I interferons. 1 / 1
| 1
reach
"Consistently, Cre-ER Otud4 fl/fl or Lyz2-Cre Otud4 fl/fl mice produce decreased levels of type I interferons and proinflammatory cytokines and exhibit increased sensitivity to VSV infection compared to their control littermates."
30410068
OTUD4 affects stimulating miR-103a-3p ZIKV replication
| 1
OTUD4 inhibits stimulating miR-103a-3p ZIKV replication. 1 / 1
| 1
eidos
"Taken together , these findings indicate that OTUD4 not only inhibits ZIKV replication through suppression of p38 MAPK signaling pathway but also attenuates the stimulating effect of miR-103a-3p on ZIKV replication ."
35317262
OTUD4 affects specific deubiquitinase
| 1
OTUD4 activates specific deubiquitinase. 1 / 1
| 1
reach
"Here, we demonstrate that the deubiquitinase OTUD4, which nominally encodes a K48 specific deubiquitinase, is phosphorylated near its catalytic domain, activating a latent K63 specific deubiquitinase."
29395066
OTUD4 affects simulating replication
| 1
OTUD4 inhibits simulating replication. 1 / 1
| 1
eidos
"Most importantly , OTUD4 attenuated the simulating effect of miR-103a-3p on ZIKV replication together with inhibition of p38 MAPK signaling pathway ( Figures 5G , H ) ."
35317262
OTUD4 affects silencing OTUD4
| 1
OTUD4 activates silencing OTUD4. 1 / 1
| 1
eidos
"Zhao et al. ( 2018 ) revealed that OTUD4 negatively modulated TLR-mediated NF-kappaB activation and silencing of OTUD4 increased the phosphorylation of p38 MAPK upon the stimulation of IL-1beta ."
35317262
OTUD4 affects pyroptosis
| 1
OTUD4 activates pyroptosis. 1 / 1
| 1
reach
"Mechanistically, OTUD4 deubiquitinated and stabilized GSDME, enhancing radiosensitivity of NPC cells by promoting pyroptosis."
36411454
OTUD4 affects pathway
| 1
OTUD4 activates pathway. 1 / 1
| 1
sparser
"OTUD4 activates the canonical TGFβ pathway."
32973272
OTUD4 affects p38
| 1
OTUD4 inhibits p38. 1 / 1
| 1
reach
"In contrast, OTUD4 over-expression inhibited p38 MAPK activation and decreased ZIKV replication."
35317262
OTUD4 affects p38 Mitogen-Activated Protein Kinase
| 1
OTUD4 activates p38 Mitogen-Activated Protein Kinase. 1 / 1
| 1
reach
"MiR-103a-3p Promotes Zika Virus Replication by Targeting OTU Deubiquitinase 4 to Activate p38 Mitogen-Activated Protein Kinase Signaling Pathway."
35317262
OTUD4 affects miR-494-3p
| 1
OTUD4 binds miR-494-3p. 1 / 1
| 1
reach
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
OTUD4 affects miR-103a-3p
| 1
OTUD4 inhibits miR-103a-3p. 1 / 1
| 1
reach
"In addition, OTUD4 over-expression attenuated the stimulating effect of miR-103a-3p on ZIKV replication and activation of p38 MAPK signaling."
35317262
OTUD4 affects host antiviral
| 1
OTUD4 activates host antiviral. 1 / 1
| 1
eidos
"However , OTUD4 positively regulates IFN signaling and enhances host antiviral activities by deubiquitinating K48-Ub on MAVS ( 66 ) ."
34707613
sparser
"Moreover, Rad51 staining confirmed that OTUD4 inhibited HR in NSCLC cells as indicated by less Rad51 foci in OTUD4 overexpressing cells after IR treatment (Fig.  xref e, f)."
31011293
OTUD4 activates defense response to virus. 1 / 1
| 1
reach
"Interestingly, one study reported that OTUD4 is induced during RNA virus infection to promote antiviral response (Liuyu et al., 2019), which is analogous to the role of OTUD4 in HSV-1 infection that we report here."
35516420
OTUD4 inhibits cell population proliferation. 1 / 1
| 1
reach
"Furthermore, overexpression of OTUD4 could inhibit tumor cell proliferation, migration and invasion of breast, liver and lung cancer cells through inhibiting the AKT signaling pathway."
32184655
OTUD4 affects cell migration
| 1
OTUD4 inhibits cell migration. 1 / 1
| 1
reach
"HIN-1 is a potent inhibitor of anchorage dependent and anchorage independent cell growth, cell migration, and invasion [XREF_BIBR, XREF_BIBR]."
20546602
OTUD4 affects cell growth
| 1
OTUD4 inhibits cell growth. 1 / 1
| 1
reach
"Reintroduction of HIN-1 into breast cancer cells inhibits cell growth."
11481438
OTUD4 affects cell cycle
| 1
OTUD4 activates cell cycle. 1 / 1
| 1
reach
"Overexpression of OTUD4 increases radiosensitivity of NSCLC cells exhibiting as impaired clonogenic formation ability, enhanced cell cycle arrest and increased cell apoptosis."
31011293
OTUD4 affects arm
| 1
OTUD4 inhibits arm. 1 / 1
| 1
reach
"HIn1 (I) extensively suppresses recombination in heterozygotes in the right arm of chromosome I from unc-75 to unc-54."
1644275
OTUD4 affects ammonium
| 1
OTUD4 activates ammonium. 1 / 1
| 1
reach
"Furthermore, the silencing of Hsp70 also suppressed l-methionine sulfoximine induced cell death and hin1 expression and caused the over-accumulation of ammonium ions."
24331433
OTUD4 affects activation miR-103a-3p p38 MAPK signaling pathway
| 1
OTUD4 inhibits activation miR-103a-3p p38 MAPK signaling pathway. 1 / 1
| 1
eidos
"Moreover , OTUD4 attenuated the activation effect of miR-103a-3p on the p38 MAPK signaling pathway as shown by the decreased phosphorylation levels of both p-p38 MAPK and p-HSP27 in the presence of OTUD4 over-expression ( Figure 5H ) ."
35317262
OTUD4 affects Zika
| 1
OTUD4 activates Zika. 1 / 1
| 1
reach
"MiR-103a-3p Promotes Zika Virus Replication by Targeting OTU Deubiquitinase 4 to Activate p38 Mitogen-Activated Protein Kinase Signaling Pathway."
35317262
OTUD4 affects ZIKV replication
| 1
OTUD4 inhibits ZIKV replication. 1 / 1
| 1
eidos
"Taken together , these findings indicate that OTUD4 not only inhibits ZIKV replication through suppression of p38 MAPK signaling pathway but also attenuates the stimulating effect of miR-103a-3p on ZIKV replication ."
35317262
OTUD4 affects XPO1
1 |
XPO1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
26673895
OTUD4 affects VTN
1 |
VTN binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUD4 affects US9
1 |
OTUD4 binds US9. 1 / 1
1 |
virhostnet
No evidence text available
31873071
OTUD4 affects US22
1 |
OTUD4 binds US22. 1 / 1
1 |
virhostnet
No evidence text available
31873071
OTUD4 affects Toll Like Receptor
| 1
OTUD4 binds Toll Like Receptor. 1 / 1
| 1
sparser
"Our mass spectrometry results suggested that OTUD4 is associated with the Toll-like receptor (TLR) associated factor MyD88 in cytosol extracts ( xref )."
29395066
OTUD4 affects TUBA1A
1 |
TUBA1A binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects TSPYL6
1 |
TSPYL6 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUD4 affects TPTE2
1 |
TPTE2 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
27880917
OTUD4 affects TLR-mediated NF-kappaB
| 1
OTUD4 activates TLR-mediated NF-kappaB. 1 / 1
| 1
eidos
"Zhao et al. ( 2018 ) revealed that OTUD4 negatively modulated TLR-mediated NF-kappaB activation and silencing of OTUD4 increased the phosphorylation of p38 MAPK upon the stimulation of IL-1beta ."
35317262
OTUD4 affects TIAL1
| 1
TIAL1 binds OTUD4 and IGF2BP3. 1 / 1
| 1
sparser
"In contrast, the interaction of IGF2BP3 and TIAR with OTUD4 was even enhanced after RNase treatment ( xref E,G)."
31138677
OTUD4 affects TCF4
1 |
TCF4 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
25416956
virhostnet
No evidence text available
30550790
OTUD4 affects STAT1
1 |
STAT1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUD4 affects SMURF2
| 1
OTUD4 inhibits SMURF2. 1 / 1
| 1
sparser
"Specifically, we find that OTUD4 enhances TGFβ signalling by promoting the membrane presence of TGFβ receptor I. Furthermore, we demonstrate that OTUD4 inactivates the TGFβ negative regulator SMURF2 suggesting that OTUD4 regulates multiple nodes of the TGFβ pathway to enhance TGFβ activity."
32973272
OTUD4 affects SMAD2
| 1
OTUD4 phosphorylates SMAD2. 1 / 1
| 1
sparser
"The observation that OTUD4 can still induce SMAD2 phosphorylation in the presence of SMURF2 29/30, despite not being able induce the inactive state of the ligase, indicates that this may be a potential mechanism of action."
32973272
OTUD4 affects Receptor Kinase 1
| 1
OTUD4 activates Receptor Kinase 1. 1 / 1
| 1
reach
"The flg22 induces the expression of defence genes such as flg22 induced Receptor Kinase 1 (FRK1), cytochrome P450 monooxygenase (CYP81F2) and NDR1 and HIN1 like 10 (NHL10) (Boudsocq etal., 2010)."
28513846
OTUD4 affects RUNX1T1
1 |
RUNX1T1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
17353931
OTUD4 affects RPTN
1 |
OTUD4 binds RPTN. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects REL
1 |
OTUD4 binds REL. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUD4 affects RC3H1
1 |
OTUD4 binds RC3H1. 1 / 1
1 |
biogrid
No evidence text available
26170170
OTUD4 affects RBP4
| 1
OTUD4 binds RBP4. 1 / 1
| 1
sparser
"Strikingly, OTUD4 interacted with many RBPs and was able to interact with RNA itself."
31138677
OTUD4 affects RBFOX2
1 |
OTUD4 binds RBFOX2. 1 / 1
1 |
biogrid
No evidence text available
26186194
OTUD4 affects PRPF4
1 |
PRPF4 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
26496610
OTUD4 affects PARP11
1 |
PARP11 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects OTUD7A
| 1
OTUD7A binds OTUD4. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD4 affects OTUD6B
| 1
OTUD6B binds OTUD4. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD4 affects OTUD3
| 1
OTUD4 binds OTUD3. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD4 affects ODAPH
1 |
OTUD4 binds ODAPH. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUD4 affects OAT
1 |
OTUD4 binds OAT. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects Neoplasms
| 1
OTUD4 activates Neoplasms. 1 / 1
| 1
reach
"The results suggest that CDH1 and HIN1 methylation heterogeneity may increase tumor metastasis."
34539742
OTUD4 activates Neoplasm Metastasis. 1 / 1
| 1
reach
"The results suggest that CDH1 and HIN1 methylation heterogeneity may increase tumor metastasis."
34539742
OTUD4 affects NTS
| 1
OTUD4 activates NTS. 1 / 1
| 1
reach
"Transcription of HIN1 was greatly upregulated by inoculation of recombinant TMVs in both Samsun nn and Samsun NN at two different temperatures (25degreesC and 33degreesC) (XREF_FIG)."
21124743
OTUD4 affects NPEPPS
1 |
OTUD4 binds NPEPPS. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects NMD3
1 |
NMD3 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects NF-kB-dependent inflammation
| 1
OTUD4 inhibits NF-kB-dependent inflammation. 1 / 1
| 1
eidos
"OTUD4 has been shown to deubiquitinate K63-linked chains of myeloid differentiation primary response 88 ( MYD88 ) and to downregulate NF-kB-dependent inflammation ."
33185526
OTUD4 affects NDRG1
| 1
OTUD4 activates NDRG1. 1 / 1
| 1
reach
"To investigate the role of WRKY46 in plant defense, we analyzed expression of a luciferase (LUC) reporter driven by a routinely used W-box-containing defense related promoter, NDR1 and HIN1 like 10 (NHL10), in Arabidopsis protoplasts co-expressing either different variants of WRKY46 or CFP (as a control for expression of a defense unrelated protein)."
26870073
OTUD4 affects NAF1
1 |
OTUD4 binds NAF1. 1 / 1
1 |
biogrid
No evidence text available
26496610
OTUD4 affects Mice
| 1
OTUD4 activates Mice. 1 / 1
| 1
reach
"The expression of NOD-like receptor pyrin domain containing 3 (NLRP3) and toll- like-receptor-4 (TLR4) was assayed by IHC in the lungs and intestine in HIN1 virus-induced mice to evaluate the whole efficacy of the protective effects on lungs and intestines."
37189778
OTUD4 affects MYCBP
1 |
OTUD4 binds MYCBP. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects MYC
| 1
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
OTUD4 affects MOG
1 |
OTUD4 binds MOG. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects MKRN3
| 1
OTUD4 binds MKRN3. 1 / 1
| 1
sparser
"We also examined MKRN3 interactions among 37 genes implicated in CHH ( xref – xref ), and found that MKRN3 interacts with OTUD4."
30800097
OTUD4 affects LHX6
1 |
LHX6 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
26186194
OTUD4 affects KRT85
1 |
OTUD4 binds KRT85. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects KRT8
1 |
OTUD4 binds KRT8. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects KRT36
1 |
OTUD4 binds KRT36. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects KRT33B
1 |
OTUD4 binds KRT33B. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects KRT31
1 |
OTUD4 binds KRT31. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects KANSL3
| 1
OTUD4 binds KANSL3. 1 / 1
| 1
sparser
"Their target sequences are as follows: ACO8-si1, GACCCTAACCTTCACAAGA; ACOT8 -si2, CCAAACAGATGTTCTGGGT; C1QBP-si1, CCACCTAAT GGATTTCCTT; C1QBP-si2, CATTTGATGGTGAGGAGGA; OTUD4-si1, GCTTCTTCATGCTGAATAT; OTUD4-si2, CCAG CAGAACATATACCTT; SNX9-si1, GTGGGTTTATCCTACCT CT; SNX9-si2, CGGATCTATGATTACAACA; VIM-si1, CAGA CAGGATGTTGACAAT; VIM-si2, CTTCTCAGCATCACGA TGA."
35516420
OTUD4 affects IQCN
1 |
OTUD4 binds IQCN. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUD4 affects ILK
1 |
OTUD4 binds ILK. 1 / 1
1 |
biogrid
No evidence text available
17353931
OTUD4 affects IFNB1
| 1
OTUD4 increases the amount of IFNB1. 1 / 1
| 1
reach
"Unexpectedly, OTUD4 also increased luciferase activity during mock infection suggesting that OTUD4 could raise the baseline expression of IFN-β in unstimulated cells."
35516420
OTUD4 affects HTRA4
1 |
OTUD4 binds HTRA4. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUD4 affects HSF2
1 |
OTUD4 binds HSF2. 1 / 1
1 |
biogrid
No evidence text available
26496610
OTUD4 affects HARPIN-INDUCED 1
| 1
OTUD4 activates HARPIN-INDUCED 1. 1 / 1
| 1
reach
"Take HARPIN INDUCED 1 (HIN1) for example, the expression of HIN1 was strongly upregulated during leaf- and flower-senescence after TMV infection in tobacco XREF_BIBR."
27157477
OTUD4 affects H3C6
1 |
OTUD4 binds H3C6. 1 / 1
1 |
biogrid
No evidence text available
26527279
OTUD4 affects GSDME
| 1
OTUD4 deubiquitinates GSDME. 1 / 1
| 1
reach
"GSDME-dependent pyroptosis is a critical determinant of radiosensitivity in NPC, and is modulated by OTUD4 via deubiquitinating and stabilizing GSDME."
36411454
OTUD4 affects GRK5
1 |
OTUD4 binds GRK5. 1 / 1
1 |
biogrid
No evidence text available
22952844
OTUD4 affects GPHN
1 |
GPHN binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects GLA
1 |
OTUD4 binds GLA. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects GAR1
1 |
GAR1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
26496610
OTUD4 affects GALK1
1 |
OTUD4 binds GALK1. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects G3BP1
| 1
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
OTUD4 affects Flag
| 1
OTUD4 binds Flag. 1 / 1
| 1
sparser
"OTUD4 was over-expressed by transfection with Flag-OTUD4 plasmid."
35317262
OTUD4 affects FXR2
1 |
OTUD4 binds FXR2. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects FMNL1
1 |
FMNL1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
23182705
OTUD4 affects FLNC
1 |
OTUD4 binds FLNC. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects FAN1
1 |
OTUD4 binds FAN1. 1 / 1
1 |
biogrid
No evidence text available
27880917
OTUD4 affects EXOSC8
1 |
EXOSC8 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUD4 affects DUSP10
1 |
OTUD4 binds DUSP10. 1 / 1
1 |
biogrid
No evidence text available
27880917
OTUD4 affects DSG1
1 |
OTUD4 binds DSG1. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects DNAJB1
1 |
OTUD4 binds DNAJB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects DNA N-methyltransferases
| 1
OTUD4 decreases the amount of DNA N-methyltransferases. 1 / 1
| 1
reach
"Furthermore, miR-29b-1-5p overexpression induces both inhibition of DNA N-methyltransferases (DNMT1, DNMT3A, and DNMT3B) expression and re-expression of HIN1, RASSF1A and CCND2."
31313842
OTUD4 affects CYLD
1 |
OTUD4 binds CYLD. 1 / 1
1 |
biogrid
No evidence text available
27591049
OTUD4 affects CLEC3B
1 |
CLEC3B binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
17353931
OTUD4 affects CDKN1B
| 1
OTUD4 inhibits CDKN1B. 1 / 1
| 1
reach
"Expression of HIN-1 also inhibits Akt mediated retention of p27 in the cytoplasm."
| PMC
OTUD4 inhibits Bacterial Infections. 1 / 1
| 1
reach
"The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection."
37193092
OTUD4 affects BRF2
1 |
BRF2 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
17353931
OTUD4 affects BAG5
1 |
OTUD4 binds BAG5. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD4 affects ATG12
1 |
OTUD4 binds ATG12. 1 / 1
1 |
biogrid
No evidence text available
17353931
OTUD4 affects AGO3
1 |
AGO3 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19167051
OTUD4 affects AGO2
| 1
OTUD4 binds AGO2. 1 / 1
| 1
sparser
"The result in Fig.  xref F revealed that compared with IgG group, quantity of miR-494-3p and OTUD4 bound by Ago2 was significantly increased."
35109842
OTUD3 affects OTUD4
| 1
OTUD4 binds OTUD3. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
ODAPH affects OTUD4
1 |
OTUD4 binds ODAPH. 1 / 1
1 |
biogrid
No evidence text available
28514442
OAT affects OTUD4
1 |
OTUD4 binds OAT. 1 / 1
1 |
biogrid
No evidence text available
19615732
NUP214 affects OTUD4
| 1
NUP214 increases the amount of OTUD4. 1 / 1
| 1
reach
"HpaXpm and the heated HpaXpm protein can effectively induce the expression of Hin1 and Hsr203J."
31906854
NPEPPS affects OTUD4
1 |
OTUD4 binds NPEPPS. 1 / 1
1 |
biogrid
No evidence text available
19615732
NMD3 affects OTUD4
1 |
NMD3 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19615732
NIBAN2 affects DNMT1
| 1
OTUD4 binds NIBAN2 and DNMT1. 1 / 1
| 1
sparser
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
NFkappaB affects OTUD4
| 1
NFkappaB activates OTUD4. 1 / 1
| 1
sparser
"OTU deubiquitinase 4 (OTUD4) is a member of OTD deubiquitinase (DUB) family, which participates in various physiological and pathological processes, such as embryonic development of zebrafish, repair of DNA alkylation damage, and innate immune response ( xref ; xref , xref ; xref ). xref revealed that OTUD4 negatively modulated TLR-mediated NF-κB activation and silencing of OTUD4 increased the phosphorylation of p38 MAPK upon the stimulation of IL-1β."
35317262
NF-kappaB signaling affects OTUD4
| 1
NF-kappaB signaling activates OTUD4. 1 / 1
| 1
eidos
"OTUD4 is induced by virus infection and targets MAVS ubiquitination , triggeringIRF3 and NF-kappaB signaling to sustain antiviral responses [ 85 ] ."
32650621
NDRG1 affects OTUD4
| 1
NDRG1 activates OTUD4. 1 / 1
| 1
reach
"To investigate the role of WRKY46 in plant defense, we analyzed expression of a luciferase (LUC) reporter driven by a routinely used W-box-containing defense related promoter, NDR1 and HIN1 like 10 (NHL10), in Arabidopsis protoplasts co-expressing either different variants of WRKY46 or CFP (as a control for expression of a defense unrelated protein)."
26870073
NAF1 affects OTUD4
1 |
OTUD4 binds NAF1. 1 / 1
1 |
biogrid
No evidence text available
26496610
MYCBP affects OTUD4
1 |
OTUD4 binds MYCBP. 1 / 1
1 |
biogrid
No evidence text available
19615732
MYC affects SMN2
| 1
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
MOG affects OTUD4
1 |
OTUD4 binds MOG. 1 / 1
1 |
biogrid
No evidence text available
19615732
MKRN3 affects OTUD4
| 1
OTUD4 binds MKRN3. 1 / 1
| 1
sparser
"We also examined MKRN3 interactions among 37 genes implicated in CHH ( xref – xref ), and found that MKRN3 interacts with OTUD4."
30800097
LHX6 affects OTUD4
1 |
LHX6 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
26186194
L-methionine sulfoximine increases the amount of OTUD4. 1 / 1
| 1
reach
"Furthermore, the silencing of Hsp70 also suppressed l-methionine sulfoximine induced cell death and hin1 expression and caused the over-accumulation of ammonium ions."
24331433
KRT85 affects OTUD4
1 |
OTUD4 binds KRT85. 1 / 1
1 |
biogrid
No evidence text available
19615732
KRT8 affects OTUD4
1 |
OTUD4 binds KRT8. 1 / 1
1 |
biogrid
No evidence text available
19615732
KRT36 affects OTUD4
1 |
OTUD4 binds KRT36. 1 / 1
1 |
biogrid
No evidence text available
19615732
KRT33B affects OTUD4
1 |
OTUD4 binds KRT33B. 1 / 1
1 |
biogrid
No evidence text available
19615732
KRT31 affects OTUD4
1 |
OTUD4 binds KRT31. 1 / 1
1 |
biogrid
No evidence text available
19615732
KANSL3 affects OTUD4
| 1
OTUD4 binds KANSL3. 1 / 1
| 1
sparser
"Their target sequences are as follows: ACO8-si1, GACCCTAACCTTCACAAGA; ACOT8 -si2, CCAAACAGATGTTCTGGGT; C1QBP-si1, CCACCTAAT GGATTTCCTT; C1QBP-si2, CATTTGATGGTGAGGAGGA; OTUD4-si1, GCTTCTTCATGCTGAATAT; OTUD4-si2, CCAG CAGAACATATACCTT; SNX9-si1, GTGGGTTTATCCTACCT CT; SNX9-si2, CGGATCTATGATTACAACA; VIM-si1, CAGA CAGGATGTTGACAAT; VIM-si2, CTTCTCAGCATCACGA TGA."
35516420
K 7174 affects OTUD4
1 |
K 7174 increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
24086573
IQCN affects OTUD4
1 |
OTUD4 binds IQCN. 1 / 1
1 |
biogrid
No evidence text available
28514442
ILK affects OTUD4
1 |
OTUD4 binds ILK. 1 / 1
1 |
biogrid
No evidence text available
17353931
IGF2BP3 affects TIAL1
| 1
TIAL1 binds OTUD4 and IGF2BP3. 1 / 1
| 1
sparser
"In contrast, the interaction of IGF2BP3 and TIAR with OTUD4 was even enhanced after RNase treatment ( xref E,G)."
31138677
IGF2BP3 affects SMN2
| 1
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
IGF2BP3 affects OTUD4, and TIAL1
| 1
TIAL1 binds OTUD4 and IGF2BP3. 1 / 1
| 1
sparser
"In contrast, the interaction of IGF2BP3 and TIAR with OTUD4 was even enhanced after RNase treatment ( xref E,G)."
31138677
IGF2BP3 affects MYC
| 1
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
ICP0-interacting proteins affects OTUD4
| 1
ICP0-interacting proteins ubiquitinates OTUD4. 1 / 1
| 1
reach
"Indeed, we confirmed that both OTUD4 and VIM could be ubiquitinated by ICP0.Our data recapitulated many of the previous reported ICP0-interacting proteins or substrates."
35516420
Hypersensitivity affects OTUD4
| 1
reach
"In this study, we demonstrated that transient overexpression of RipI induces the hypersensitive response (HR), up-regulating the HR marker gene hin1, in Nicotiana benthamiana."
32285606
HTRA4 affects OTUD4
1 |
OTUD4 binds HTRA4. 1 / 1
1 |
biogrid
No evidence text available
28514442
HSF2 affects OTUD4
1 |
OTUD4 binds HSF2. 1 / 1
1 |
biogrid
No evidence text available
26496610
HIN2 affects OTUD4
| 1
HIN2 activates OTUD4. 1 / 1
| 1
reach
"The tetrameric HIN2 serves as the central platform for HIN1 to append to and increases the avidity of dsDNA binding of HIN1."
23850291
HDAC affects OTUD4
1 |
HDAC increases the amount of OTUD4. 1 / 1
1 |
bel
"We next sought to identify a set of genes whose expression was inhibited by both FR235222 and oxamflatin in a pattern similar to that of their transcriptional inhibition of GATA-1. Using GeneSpring software, this analysis identified 80 genes having a good correlation (R > 0.98) with the repression of GATA-1 gene (Fig. 3 and supplementary data). "
17628529
HCM1 affects OTUD4
| 1
HCM1 activates OTUD4. 1 / 1
| 1
reach
"The results showed that HIN1, HSR203J and PR1-a were induced by Hcm1 as by Hpa1, suggesting that the chimeric protein Hcm1, like Hpa1, activates plant defence responses (XREF_FIG)."
21895994
H3C6 affects OTUD4
1 |
OTUD4 binds H3C6. 1 / 1
1 |
biogrid
No evidence text available
26527279
GRK5 affects OTUD4
1 |
OTUD4 binds GRK5. 1 / 1
1 |
biogrid
No evidence text available
22952844
GPHN affects OTUD4
1 |
GPHN binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19615732
GLA affects OTUD4
1 |
OTUD4 binds GLA. 1 / 1
1 |
biogrid
No evidence text available
19615732
GAR1 affects OTUD4
1 |
GAR1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
26496610
GALK1 affects OTUD4
1 |
OTUD4 binds GALK1. 1 / 1
1 |
biogrid
No evidence text available
19615732
G3BP1 affects SMN2
| 1
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
Flag affects OTUD4
| 1
OTUD4 binds Flag. 1 / 1
| 1
sparser
"OTUD4 was over-expressed by transfection with Flag-OTUD4 plasmid."
35317262
FXR2 affects OTUD4
1 |
OTUD4 binds FXR2. 1 / 1
1 |
biogrid
No evidence text available
19615732
FMNL1 affects OTUD4
1 |
FMNL1 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
23182705
FLNC affects OTUD4
1 |
OTUD4 binds FLNC. 1 / 1
1 |
biogrid
No evidence text available
19615732
FAN1 affects OTUD4
1 |
OTUD4 binds FAN1. 1 / 1
1 |
biogrid
No evidence text available
27880917
EXOSC8 affects OTUD4
1 |
EXOSC8 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
25416956
ELAVL2 affects MYC
| 1
SMN2 binds OTUD4, IGF2BP3, ELAVL2, and MYC. 1 / 1
| 1
sparser
"We found that endogenous SMN1, FLAG-tagged HuB (also known as ELAVL2) and Myc–IGF2BP3 interacted with OTUD4 ( xref C–E;)."
31138677
ELAVL2 affects G3BP1, OTUD4, and SMN2
| 1
SMN2 binds OTUD4, G3BP1, and ELAVL2. 1 / 1
| 1
sparser
"In fact, treatment of lysates with RNase prior to IP reduced or abolished the interaction of OTUD4 with SMN1, HuB and G3BP1, suggesting that OTUD4 binds to these proteins via RNA ( xref C,D,F, right lane of each panel)."
31138677
DUSP10 affects OTUD4
1 |
OTUD4 binds DUSP10. 1 / 1
1 |
biogrid
No evidence text available
27880917
DSG1 affects OTUD4
1 |
OTUD4 binds DSG1. 1 / 1
1 |
biogrid
No evidence text available
19615732
DNMT1 affects NIBAN2, and OTUD4
| 1
OTUD4 binds NIBAN2 and DNMT1. 1 / 1
| 1
sparser
"ChIP, RNA binding protein immunoprecipitation assay and dual-luciferase reporter gene assay were applied to verify interaction between DNMT1 and MEG3, miR-494-3p and MEG3 and OTUD4."
35109842
DNAJB1 affects OTUD4
1 |
OTUD4 binds DNAJB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
DDIT3 affects OTUD4
1 |
DDIT3 decreases the amount of OTUD4. 1 / 1
1 |
biopax:msigdb
No evidence text available
CYLD affects OTUD4
1 |
OTUD4 binds CYLD. 1 / 1
1 |
biogrid
No evidence text available
27591049
CLEC3B affects OTUD4
1 |
CLEC3B binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
17353931
CK2 affects OTUD4
| 1
CK2 phosphorylates OTUD4. 1 / 1
| 1
sparser
"Studies have confirmed that casein kinase II (CK2) induces the phosphorylation of OTUD4 at residues Ser202, which is adjacent to the catalytic OTU domain ( xref )."
34177595
BRF2 affects OTUD4
1 |
BRF2 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
17353931
BAG5 affects OTUD4
1 |
OTUD4 binds BAG5. 1 / 1
1 |
biogrid
No evidence text available
19615732
ATM affects OTUD4
| 1
ATM phosphorylates OTUD4. 1 / 1
| 1
sparser
"Because K63 polyubiquitination plays pivotal roles in HR repair [ xref ], we propose a hypothesis that OTUD4 might be phosphorylated by ATM and thus function as a K63-specific deubiquitinase to inhibit DSBs HR repair."
31011293
ATG12 affects OTUD4
1 |
OTUD4 binds ATG12. 1 / 1
1 |
biogrid
No evidence text available
17353931
ALKBH2 affects OTUD4
1 |
OTUD4 binds ALKBH2. 1 / 1
1 |
biogrid
No evidence text available
25944111
AGO3 affects OTUD4
1 |
AGO3 binds OTUD4. 1 / 1
1 |
biogrid
No evidence text available
19167051
AGO2 affects OTUD4
| 1
OTUD4 binds AGO2. 1 / 1
| 1
sparser
"The result in Fig.  xref F revealed that compared with IgG group, quantity of miR-494-3p and OTUD4 bound by Ago2 was significantly increased."
35109842
5-aza-2-dC affects OTUD4
| 1
5-aza-2-dC increases the amount of OTUD4. 1 / 1
| 1
reach
"These results demonstrated that 5-aza-2-dC may increase the expression of HIN-1 by decreasing the AKT-mTOR expression in paclitaxel resistant OCCC tumor cells."
26497956
reach
"Furthermore, AM580 decreases palmitolyation of the surface glycoprotein haemagglutinin of the RNA virus HIN1, thereby impairing replication of influenza59,60."
| PMC
2,4,6-trinitrobenzenesulfonic acid decreases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
17982090
(+)-abscisic acid affects OTUD4
| 1
reach
"Highly ABA Induced 1 (HAI1)-Interacting protein HIN1 and drought acclimation enhanced splicing efficiency at intron retention sites."
31611386
5-aza-2'-deoxycytidine affects OTUD4
| 1
5-aza-2'-deoxycytidine leads to the demethylation of OTUD4. 1 / 1
| 1
reach
"5-aza-2 '-deoxycytidine reverses HIN-1 methylation and reduces viability of gastric cancer cells."
21274384
2,4,5,2',5'-pentachlorobiphenyl increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25510870
2,4,4'-trichlorobiphenyl increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25510870
2,2',5,5'-tetrachlorobiphenyl increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25510870
2,2',4,4',5,5'-hexachlorobiphenyl increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25510870
2,2',3',4,4',5-hexachlorobiphenyl increases the amount of OTUD4. 1 / 1
1 |
ctd
No evidence text available
25510870