IndraLab

Statements

OTUB2 affects U2AF2
| 15 8
OTUB2 binds U2AF2.
| 8 8
OTUB2 binds U2AF2. 10 / 14
| 8 6
sparser
"Then the interaction between OTUB2 and U2 small nuclear RNA auxiliary factor 2 (U2AF2) was found through the immunoprecipitation method."
35309903
reach
"In addition, immunoprecipitation assays using an antibody against endogenous OTUB2 revealed endogenous interactions between OTUB2 and U2AF2."
30662561
reach
"Furthermore, the interaction between endogenous OTUB2 and U2AF2 was demonstrated by co-immunoprecipitation using an antibody against endogenous U2AF2 in A549 and H1299 cells."
30662561
reach
"These data collectively suggest that OTUB2 interacts with and stabilizes U2AF2 in NSCLC cells."
30662561
reach
"This finding led us to hypothesize that OTUB2 directly interacts with and deubiquitinates U2AF2."
30662561
reach
"Our data provide ample evidence to demonstrate that OTUB2 binds to U2AF2, efficiently deubiquitinating it by removing the K-48 polyubiquitin chains and protecting it from proteasomal degradation."
30662561
sparser
"Furthermore, the interaction between endogenous OTUB2 and U2AF2 was demonstrated by co-immunoprecipitation using an antibody against endogenous U2AF2 in A549 and H1299 cells (Figure xref D)."
30662561
reach
"These results indicate that OTUB2 specifically interacts with U2AF2 in NSCLC cells."
30662561
reach
"One approach, using point mutants of these proteins that specifically disrupt the U2AF2 and OTUB2 interaction, may deepen our understanding of the OTUB2 regulation of U2AF2."
30662561
sparser
"Our data provide ample evidence to demonstrate that OTUB2 binds to U2AF2, efficiently deubiquitinating it by removing the K-48 polyubiquitin chains and protecting it from proteasomal degradation."
30662561
OTUB2 binds U2AF2 and PGK1. 2 / 2
| 2
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"High expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
sparser
"In addition, our results suggest that high expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
OTUB2 deubiquitinates U2AF2.
| 3
OTUB2 deubiquitinates U2AF2. 3 / 3
| 3
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"OTUB2 knockdown significantly enhanced the levels of U2AF2 ubiquitination and K48 linked polyubiquitin chains in H1299 cells, whereas OTUB2 overexpression significantly reduced the levels of U2AF2 ubiquitination and K48 linked polyubiquitin chains in XL-2 cells."
30662561
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"This finding led us to hypothesize that OTUB2 directly interacts with and deubiquitinates U2AF2."
30662561
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"Of note, U2AF2 deubiquitination by OTUB2 is important for U2AF2 stabilization."
30662561
OTUB2 decreases the amount of U2AF2.
| 2
OTUB2 decreases the amount of U2AF2. 2 / 2
| 2
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"Knockdown of OTUB2 significantly inhibited the U2AF2 protein levels in A549 and H1299 cells but had no impact on U2AF2 mRNA levels."
30662561
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"We first examined the mRNA and protein levels of U2AF2 following OTUB2 knockdown or overexpression in MG132 treated NSCLC cell lines wherein global proteasomal activity was inhibited."
30662561
OTUB2 activates U2AF2.
| 2
OTUB2 activates U2AF2. 2 / 2
| 2
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"Consistently, OTUB2 overexpression in XL-2 and H292 cells increased the half-life of U2AF2 protein in the presence of CHX."
30662561
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"Taken together, these results indicate that OTUB2 promotes xenograft tumor growth of NSCLC cells by stabilizing U2AF2 and enhancing the Warburg effect In vivo."
30662561
OTUB2 affects TRAF6
2 1 | 2 11 4
OTUB2 binds TRAF6.
2 | 2 3
TRAF6 binds OTUB2. 5 / 5
2 | 2 1
biogrid
No evidence text available
19996094
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"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
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"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63 linked polyubiquitin chains."
33511009
sparser
"More than this special feature, if OTUB2 interacts with TRAF6, the result should benefit the NF-kappaB pathway."
35309903
biogrid
No evidence text available
23105109
TRAF3 binds TRAF6, OTUB2, and OTUB1. 2 / 2
| 2
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains.[ 172 ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
OTUB2 inhibits TRAF6.
| 2 3 1
OTUB2 inhibits TRAF6. 6 / 6
| 2 3 1
eidos
"TRAF6 are inhibited by A20 , CYLD and OTUB2 that specially remove TRAF6 K63-linked ubiquitination ."
28744851
eidos
"TRAF3 and TRAF6 are both deactivated by the DUbs otubain 1 ( OTUB1 ) and OTUB2 , which remove K63-linked polyubiquitin chains ( Li et al ., 2010b ) ."
26712804
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"TRAF3 and TRAF6 are both deactivated by the DUbs otubain 1 (OTUB1) and OTUB2, which remove K63-linked polyubiquitin chains (Li et al., 2010b) ."
26712804
reach
"TRAF3 and TRAF6 are both deactivated by the DUbs otubain 1 (OTUB1) and OTUB2, which remove K63 linked polyubiquitin chains."
26712804
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"TRAF6 are inhibited by A20, CYLD and OTUB2 that specially remove TRAF6 K63‐linked ubiquitination."
28744851
sparser
"TRAF6 are inhibited by A20, CYLD and OTUB2 that specially remove TRAF6 K63‐linked ubiquitination."
28744851
OTUB2 deubiquitinates TRAF6.
1 | 5
OTUB2 deubiquitinates TRAF6. 6 / 6
1 | 5
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
28717359
reach
"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus-induced IFN-β expression and cellular antiviral responses (53)."
28717359
reach
"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
32650621
reach
"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
23845989
reach
"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
ubibrowser
"Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6"
19996094
OTUB2 activates TRAF6.
| 1
OTUB2 activates TRAF6. 1 / 1
| 1
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"Mechanistically, OTUB2 overexpression can activate NF-kappaB signaling mostly by stabilizing TRAF6."
30588107
U2AF2 affects OTUB2
| 9 8
U2AF2 binds OTUB2.
| 8 8
OTUB2 binds U2AF2. 10 / 14
| 8 6
sparser
"Then the interaction between OTUB2 and U2 small nuclear RNA auxiliary factor 2 (U2AF2) was found through the immunoprecipitation method."
35309903
reach
"In addition, immunoprecipitation assays using an antibody against endogenous OTUB2 revealed endogenous interactions between OTUB2 and U2AF2."
30662561
reach
"Furthermore, the interaction between endogenous OTUB2 and U2AF2 was demonstrated by co-immunoprecipitation using an antibody against endogenous U2AF2 in A549 and H1299 cells."
30662561
reach
"These data collectively suggest that OTUB2 interacts with and stabilizes U2AF2 in NSCLC cells."
30662561
reach
"This finding led us to hypothesize that OTUB2 directly interacts with and deubiquitinates U2AF2."
30662561
reach
"Our data provide ample evidence to demonstrate that OTUB2 binds to U2AF2, efficiently deubiquitinating it by removing the K-48 polyubiquitin chains and protecting it from proteasomal degradation."
30662561
sparser
"Furthermore, the interaction between endogenous OTUB2 and U2AF2 was demonstrated by co-immunoprecipitation using an antibody against endogenous U2AF2 in A549 and H1299 cells (Figure xref D)."
30662561
reach
"These results indicate that OTUB2 specifically interacts with U2AF2 in NSCLC cells."
30662561
reach
"One approach, using point mutants of these proteins that specifically disrupt the U2AF2 and OTUB2 interaction, may deepen our understanding of the OTUB2 regulation of U2AF2."
30662561
sparser
"Our data provide ample evidence to demonstrate that OTUB2 binds to U2AF2, efficiently deubiquitinating it by removing the K-48 polyubiquitin chains and protecting it from proteasomal degradation."
30662561
OTUB2 binds U2AF2 and PGK1. 2 / 2
| 2
sparser
"High expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
sparser
"In addition, our results suggest that high expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
U2AF2 inhibits OTUB2.
| 1
U2AF2 inhibits OTUB2. 1 / 1
| 1
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"Importantly, knockdown of U2AF2 rescued the promoting effect of OTUB2 on H292 cell migration and invasion."
30662561
OTUB2 affects TRAF3
1 1 | 1 11 2
OTUB2 deubiquitinates TRAF3.
1 | 7
OTUB2 deubiquitinates TRAF3. 8 / 8
1 | 7
reach
"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
reach
"Furthermore, we found that OTUB1 and OTUB2 mediated virus triggered deubiquitination of TRAF3 and -6."
19996094
ubibrowser
"Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6"
19996094
reach
"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
23845989
reach
"Two close relatives of DUBA, OTUB1 and OTUB2, were shown to reduce TRAF3 ubiquitination coupled with decreased anti-viral signaling responses in Sendai virus infected HEK 293T cells."
22017431
reach
"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
28717359
reach
"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus-induced IFN-β expression and cellular antiviral responses (53)."
28717359
reach
"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
32650621
OTUB2 binds TRAF3.
1 | 2 2
TRAF3 binds OTUB2. 3 / 3
1 | 2
reach
"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
reach
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63 linked polyubiquitin chains."
33511009
biogrid
No evidence text available
19996094
TRAF3 binds TRAF6, OTUB2, and OTUB1. 2 / 2
| 2
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains.[ 172 ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
OTUB2 inhibits TRAF3.
| 1 2
OTUB2 inhibits TRAF3. 3 / 3
| 1 2
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"TRAF3 and TRAF6 are both deactivated by the DUbs otubain 1 (OTUB1) and OTUB2, which remove K63 linked polyubiquitin chains."
26712804
reach
"TRAF3 and TRAF6 are both deactivated by the DUbs otubain 1 (OTUB1) and OTUB2, which remove K63-linked polyubiquitin chains (Li et al., 2010b) ."
26712804
eidos
"TRAF3 and TRAF6 are both deactivated by the DUbs otubain 1 ( OTUB1 ) and OTUB2 , which remove K63-linked polyubiquitin chains ( Li et al ., 2010b ) ."
26712804
OTUB2 affects Ubiquitin
| 3 6
OTUB2 binds Ubiquitin.
| 2 6
Ubiquitin binds OTUB2. 8 / 11
| 2 6
sparser
"Since OTUB2 does not have the N-terminal helix and its α1α2 loop is 2 residues shorter, it is expected that the binding of proximal Ub to OTUB2 is substantially different from OTUB1."
25590432
sparser
"The deleterious effect of NEM on OTU2 UB chain binding indicates that other Cys residues are likely critical."
24659992
reach
"Since OTUB2 does not have the N-terminal helix and its alpha1alpha2 loop is 2 residues shorter, it is expected that the binding of proximal Ub to OTUB2 is substantially different from OTUB1."
25590432
sparser
"Structure of human OTUB2 bound to Ub."
25590432
sparser
"Among the eleven A. thaliana OTU DUBs examined, we found that OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
sparser
"A. thaliana OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
reach
"Structure of human OTUB2 bound to Ub."
25590432
sparser
"Interestingly, there is a novel oxyanion hole inside OTUB2 generated by the active site loop, which may be conducive to the interaction between OTUB2 and ubiquitin ( xref )."
35309903
OTUB2 inhibits Ubiquitin.
| 1
OTUB2 inhibits Ubiquitin. 1 / 1
| 1
reach
"These data, combined with the observation that NCS induced formation of RAP80 foci was inhibited by OTUB2 overexpression and accelerated by OTUB2 depletion, indicate that OTUB2 negatively regulates DN[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
OTUB2 is modified
| 12
OTUB2 is sumoylated. 8 / 8
| 8
sparser
"In breast cancer patients, there is a good correlation between the levels of KRAS and the levels of OTUB2 sumoylation as wells as the levels of Yap/Taz protein expression ( xref )."
33869224
sparser
"A yet-unknown SUMO-interacting motif (SIM) in YAP and TAZ was required for the association of YAP/TAZ with SUMOylated OTUB2."
36264492
sparser
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ."
36264492
sparser
"Sumoylated OTUB2 interacts specifically with yet-unidentified sumo interaction motifs (SIMs) in WW domain-containing transcription factor (TAZ) and Yes-associated protein (YAP) to regulate protein activity and TAZ/YAP polyubiquitination in a Hippo-independent manner."
35110531
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"Additionally, EGF therapy or KRAS mutation stabilizes YAP/TAZ expression and OTUB2 sumoylation [ xref ]."
35110531
sparser
"Poly-SUMOylated OTUB2, which was induced by Epidermal growth factor (EGF) and oncogenic KRAS, was shown to bind and activate YAP/TAZ promoting tumor metastasis [ xref ]."
31619007
sparser
"We also identified a yet-unknown SUMO-interacting motif (SIM) in YAP and TAZ required for their association with SUMOylated OTUB2."
30472188
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"Hence, OTUB2 sumoylation represents a novel mechanism that links the oncogenic EGFR-RAS pathway to Yap/Taz activation and a potential therapeutic target for cancer treatment."
33869224
OTUB2 is sumoylated on K233. 4 / 4
| 4
sparser
"In mouse breast cancer cells, OTUB2 is SUMOylated at the Lys233 site after translation, and modified OTUB2 relies on this modification to interact with SUMO-interacting motif (SIM) of YAP/TAZ to perform its deubiquitination function, ultimately affecting cancer metastasis ( xref )."
35309903
sparser
"OTUB2, a deubiquitinating cysteine protease, has been shown to deubiquitinate and activate YAP/TAZ in RAS-transformed MCF10A cells, which is dependent on poly-SUMOylation of OTUB2 on lysine 233 ( xref ) [ xref ]."
36264492
sparser
"Nowadays, for the modification regulation of OTUB2, only SUMOylation of the Lys233 site of OTUB2 is confirmed to interact with Yes-associated protein/transcriptional co-activator with PDZ-binding motif (YAP/TAZ), thereby enhancing the activity of OTUB2 and mediating the transfer of ubiquitin ( xref )."
35309903
sparser
"Interestingly, OTUB2 is sumoylated on Lys 233, which promotes its association with Yap/Taz via a conserved but previously uncharacterized SUMO-interacting motif (SIM) in Yap/Taz ( xref )."
33869224
Ubiquitin affects OTUB2
| 2 6
Ubiquitin binds OTUB2. 8 / 11
| 2 6
sparser
"Since OTUB2 does not have the N-terminal helix and its α1α2 loop is 2 residues shorter, it is expected that the binding of proximal Ub to OTUB2 is substantially different from OTUB1."
25590432
sparser
"The deleterious effect of NEM on OTU2 UB chain binding indicates that other Cys residues are likely critical."
24659992
reach
"Since OTUB2 does not have the N-terminal helix and its alpha1alpha2 loop is 2 residues shorter, it is expected that the binding of proximal Ub to OTUB2 is substantially different from OTUB1."
25590432
sparser
"Structure of human OTUB2 bound to Ub."
25590432
sparser
"Among the eleven A. thaliana OTU DUBs examined, we found that OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
sparser
"A. thaliana OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
reach
"Structure of human OTUB2 bound to Ub."
25590432
sparser
"Interestingly, there is a novel oxyanion hole inside OTUB2 generated by the active site loop, which may be conducive to the interaction between OTUB2 and ubiquitin ( xref )."
35309903
OTUB2 affects L3MBTL1
1 | 10
OTUB2 deubiquitinates L3MBTL1.
1 | 6
OTUB2 deubiquitinates L3MBTL1. 7 / 7
1 | 6
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"In addition, DSB induced L3MBTL1 ubiquitination (Acs et al., 2011) was also antagonized by OTUB2 in a DUB activity dependent manner."
24560272
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"These data suggest that the interaction between OTUB2 and L3MBTL1 is constitutive rather than DNA damage dependent.Next, we investigated whether OTUB2 could deubiquitinate L3MBTL1 in vivo."
24560272
reach
"However, OTUB2 deubiquitinates L3MBTL1 and suppresses the RNF8 mediated ubiquitination of L3MBTL1, which leads to less recruitment of RAP80 and 53BP1 to DSBs and therefore increases HR."
30831436
ubibrowser
"Mechanistically, OTUB2 suppresses RNF8-mediated L3MBTL1 ubiquitination and Lys 63-linked ubiquitin chain formation in a deubiquitinating activity-dependent manner."
24560272
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"Finally, we investigated whether OTUB2 could deubiquitinate L3MBTL1 in vitro."
24560272
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"Because ubiquitination of L3MBTL1 is a prerequisite for L3MBTL1 removal from damaged chromatin (Acs et al., 2011), we conclude that OTUB2 deubiquitinates L3MBTL1 and suppresses the accelerated removal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
reach
"Thus, OTUB2 deubiquitinates L3MBTL1 in vivo and in vitro."
24560272
OTUB2 binds L3MBTL1.
| 2
L3MBTL1 binds OTUB2. 2 / 2
| 2
reach
"These data suggest that the interaction between OTUB2 and L3MBTL1 is constitutive rather than DNA damage dependent.Next, we investigated whether OTUB2 could deubiquitinate L3MBTL1 in vivo."
24560272
reach
"Therefore, we focused on L3MBTL1 and asked whether OTUB2 prevented RNF8 mediated ubiquitination of L3MBTL1.First, to confirm whether OTUB2 interacts with L3MBTL1, we performed a coimmunoprecipitation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
OTUB2 ubiquitinates L3MBTL1.
| 1
OTUB2 leads to the ubiquitination of L3MBTL1. 1 / 1
| 1
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"A slight increment in OTUB2 at sites of DSB, which can be detected only by micro-laser irradiation, probably elevates overall DUB activity of OTUB2 to respond the DSB induced ubiquitination of L3MBTL1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
OTUB2 decreases the amount of L3MBTL1.
| 1
OTUB2 decreases the amount of ubiquitinated L3MBTL1. 1 / 1
| 1
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"When in vivo ubiquitinated L3MBTL1 was incubated with recombinant OTUB2 proteins, recombinant OTUB2 decreased the amount of ubiquitinated L3MBTL1 and generated ubiquitin monomers."
24560272
TRAF6 affects OTUB2
2 | 2 3
TRAF6 binds OTUB2. 5 / 5
2 | 2 1
biogrid
No evidence text available
19996094
reach
"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
reach
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63 linked polyubiquitin chains."
33511009
sparser
"More than this special feature, if OTUB2 interacts with TRAF6, the result should benefit the NF-kappaB pathway."
35309903
biogrid
No evidence text available
23105109
TRAF3 binds TRAF6, OTUB2, and OTUB1. 2 / 2
| 2
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains.[ 172 ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
OTUB2 activates cell population proliferation. 7 / 7
| 7
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"We also confirmed that OTUB2 enhanced the proliferation, migration, and invasion abilities of NSCLC cells In vitro."
30662561
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"In conclusion, our study indicated that OTUB2 could promote the malignant proliferation and migration of HCC cells by increasing the stability of PJA1 via deubiquitylation."
35611163
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"The overexpression of OTUB2 promoted glycolysis and induced the proliferation, migration, and invasion of endometrial cancer cells."
36316812
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"OTUB2 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells by PJA1 Deubiquitylation."
35611163
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"Functionally, the overexpression of OTUB2 could promote malignant proliferation and metastasis of HCC cells, while knockdown of OTUB2 exerted the opposite results."
35611163
reach
"OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer."
35110531
reach
"Correction: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer."
35440577
OTUB2 affects OTUB1
| 7
OTUB2 binds OTUB1. 5 / 5
| 5
sparser
"Next, Kaplan-Meier's survival analysis was performed to examine the expression of five deubiquitinating enzymes in 117 NSCLC patients (GEO Submission: GSE13213) and revealed that the higher expression of OTUB1 and OTUB2 was significantly associated with poor patient prognosis (Figure xref B-EandFigure xref E)."
30662561
sparser
"OTU1 and OTU2 ( R. radiotolerans ) associated to the meteorites ( p = 0.034), as did OTU5 ( Blastococcus sp.) p = 0.034, OTU6 ( G. pulveris ) p = 0.034, OTU12 (Chloroflexi) p = 0.028, OTU15 ( B. jejuensis ) p = 0.034, OTU19 (Frankiales) p = 0.034, OTU21 ( D. navajonensis ) p = 0.034, and OTU23 ( Rubrobacter sp.) p = 0.032."
28713354
sparser
"Binding of Known Covalent SARS-CoV PLpro Inhibitors to OTUB2/OTUB1/SARS-CoV-2 PLpro."
34071582
sparser
"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus-triggered IRF3 and NF-κB activation [ xref ]."
23151130
sparser
"On the other hand, OTU1-OTU3 comparisons showed four total upregulated and 88 downregulated genes in OTU1-dominated communities, whereas OTU1-OTU2 comparisons showed 751 total upregulated and 403 downregulated genes in OTU1-dominated communities ( xref )."
31455638
TRAF3 binds TRAF6, OTUB2, and OTUB1. 2 / 2
| 2
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains.[ 172 ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
OTUB2 affects NFkappaB
| 4
OTUB2 activates NFkappaB.
| 3
OTUB2 activates NFkappaB. 3 / 4
| 3
reach
"Mechanistically, OTUB2 overexpression can activate NF-kappaB signaling mostly by stabilizing TRAF6."
30588107
reach
"Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-kappaB signaling."
32003539
reach
"Our further investigations revealed that knockdown of OTUB2 significantly suppressed NF-kappaB-driving luciferase activity, and markedly inhibited the phosphorylation of NF-kappaB p65 in liver cancer cells, which indicated that OTUB2 mediated liver cancer cell growth by regulating NF-kappaB signaling."
32003539
OTUB2 inhibits NFkappaB.
| 1
OTUB2 inhibits NFkappaB. 1 / 3
| 1
reach
"Overexpression of OTUB1 and OTUB2 inhibited virus induced activation of IRF3 and NF-kappaB, transcription of the IFNB1 gene as well as cellular antiviral response, whereas knockdown of OTUB1 and OTUB2 had opposite effects."
19996094
OTUB2 affects GLI2
| 5 2
OTUB2 binds GLI2.
| 1 2
OTUB2 binds GLI2. 3 / 3
| 1 2
reach
"The authors found that OTUB2 formed a complex with Gli2 and promoted Gli2 deubiquitination both in vitro and in vivo."
| PMC
sparser
"The authors found that OTUB2 formed a complex with Gli2 and promoted Gli2 deubiquitination both in vitro and in vivo."
| PMC
sparser
"Meanwhile, the interaction between OTUB2 and Gli2 was determined by immunoprecipitation ( xref )."
35309903
OTUB2 inhibits GLI2.
| 2
OTUB2 inhibits ubiquitinated GLI2. 1 / 1
| 1
reach
"Invitro deubiquitination assay showed that ubiquitinated Gli2 was decreased by wild-type OTUB2 but not OTUB2 mutations."
30241937
Mutated OTUB2 inhibits ubiquitinated GLI2. 1 / 1
| 1
reach
"Invitro deubiquitination assay showed that ubiquitinated Gli2 was decreased by wild-type OTUB2 but not OTUB2 mutations."
30241937
OTUB2 deubiquitinates GLI2.
| 1
OTUB2 leads to the deubiquitination of GLI2. 1 / 1
| 1
reach
"We also found that knockdown of OTUB2 reduced deubiquitination of Gli2 invivo."
30241937
OTUB2 decreases the amount of GLI2.
| 1
OTUB2 decreases the amount of GLI2. 1 / 1
| 1
reach
"Knockdown of OTUB2 decreased Gli2 protein level while the proteasome inhibitor MG-132 treatment restored Gli2 expression."
30241937
OTUB1 affects OTUB2
| 7
OTUB2 binds OTUB1. 5 / 5
| 5
sparser
"Next, Kaplan-Meier's survival analysis was performed to examine the expression of five deubiquitinating enzymes in 117 NSCLC patients (GEO Submission: GSE13213) and revealed that the higher expression of OTUB1 and OTUB2 was significantly associated with poor patient prognosis (Figure xref B-EandFigure xref E)."
30662561
sparser
"OTU1 and OTU2 ( R. radiotolerans ) associated to the meteorites ( p = 0.034), as did OTU5 ( Blastococcus sp.) p = 0.034, OTU6 ( G. pulveris ) p = 0.034, OTU12 (Chloroflexi) p = 0.028, OTU15 ( B. jejuensis ) p = 0.034, OTU19 (Frankiales) p = 0.034, OTU21 ( D. navajonensis ) p = 0.034, and OTU23 ( Rubrobacter sp.) p = 0.032."
28713354
sparser
"Binding of Known Covalent SARS-CoV PLpro Inhibitors to OTUB2/OTUB1/SARS-CoV-2 PLpro."
34071582
sparser
"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus-triggered IRF3 and NF-κB activation [ xref ]."
23151130
sparser
"On the other hand, OTU1-OTU3 comparisons showed four total upregulated and 88 downregulated genes in OTU1-dominated communities, whereas OTU1-OTU2 comparisons showed 751 total upregulated and 403 downregulated genes in OTU1-dominated communities ( xref )."
31455638
TRAF3 binds TRAF6, OTUB2, and OTUB1. 2 / 2
| 2
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains.[ 172 ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
OTUB2 affects COV1
| 6
OTUB2 binds COV1. 6 / 6
| 6
sparser
"Further fragment analogue evaluation yielded the best inhibitor OTUB2-COV-1 ( xref ) with the k inact / K I value of 3.75 M −1 s −1 ."
34458789
sparser
"IsoTOP-ABPP demonstrated that OTUB2-COV-1 (10 μM compound, 2 h incubation) labeled <1% probe-accessible cysteines (Heavy/Light ratio >4) in HEK293T cells suggesting promising selectivity profile suitable for further development."
34458789
sparser
"Small molecule inhibitors for OTUB2 (OTUB2-COV-1) [ xref ] and USP4 (NR) [ xref ] have also been identified."
35204803
sparser
"Small molecule inhibitors for OTUB2 (OTUB2-COV-1) [102] and USP4 (NR) [103] have also been identified."
35204803
sparser
"Further fragment analogue evaluation yielded the best inhibitor OTUB2-COV-1 (Fig. 2C) with the kinact/KI value of 3.75 M−1 s−1."
34458789
sparser
"Recently, the first highly selective OTUB2 covalent inhibitor named OTUB2-COV-1 ( 38 , xref ) was identified by combining a new high-throughput thiol-reactivity assay with high-throughput crystallography [ xref ]."
32196552
2,3,7,8-tetrachlorodibenzodioxine increases the amount of OTUB2.
5 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of OTUB2. 5 / 5
5 |
ctd
No evidence text available
20106945
ctd
No evidence text available
29704546
ctd
No evidence text available
21215274
ctd
No evidence text available
17942748
ctd
No evidence text available
21632981
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of OTUB2.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
29704546
TRAF3 affects OTUB2
1 | 2 2
TRAF3 binds OTUB2. 3 / 3
1 | 2
reach
"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
reach
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63 linked polyubiquitin chains."
33511009
biogrid
No evidence text available
19996094
TRAF3 binds TRAF6, OTUB2, and OTUB1. 2 / 2
| 2
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains.[ 172 ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
KRAS affects OTUB2
| 2 3
KRAS leads to the sumoylation of OTUB2. 5 / 5
| 2 3
sparser
"Furthermore, OTUB2 sumoylation is stimulated by EGF and oncogenic KRAS, which is essential for EGF and KRAS to stabilize Yap/Taz ( xref )."
33869224
sparser
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ."
30472188
reach
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP and TAZ."
30472188
reach
"Poly-SUMOylated OTUB2, which was induced by Epidermal growth factor (EGF) and oncogenic KRAS, was shown to bind and activate YAP/TAZ promoting tumor metastasis [68]."
31619007
sparser
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ."
36264492
EGF affects OTUB2
| 2 3
EGF leads to the sumoylation of OTUB2. 5 / 5
| 2 3
sparser
"Furthermore, OTUB2 sumoylation is stimulated by EGF and oncogenic KRAS, which is essential for EGF and KRAS to stabilize Yap/Taz ( xref )."
33869224
sparser
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ."
30472188
sparser
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ."
36264492
reach
"Poly-SUMOylated OTUB2, which was induced by Epidermal growth factor (EGF) and oncogenic KRAS, was shown to bind and activate YAP/TAZ promoting tumor metastasis [68]."
31619007
reach
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP and TAZ."
30472188
Valproic acid affects OTUB2
4 |
Valproic acid decreases the amount of OTUB2.
3 |
Valproic acid decreases the amount of OTUB2. 3 / 3
3 |
ctd
No evidence text available
27188386
ctd
No evidence text available
26272509
ctd
No evidence text available
23179753
Valproic acid methylates OTUB2.
1 |
Valproic acid methylates OTUB2. 1 / 1
1 |
ctd
No evidence text available
29154799
UBC affects OTUB2
4 |
UBC binds OTUB2. 4 / 4
4 |
biogrid
No evidence text available
25590432
biogrid
No evidence text available
23827681
biogrid
No evidence text available
25590432
biogrid
No evidence text available
18954305
OTUB2 affects pathway
| 4
OTUB2 activates pathway. 4 / 4
| 4
sparser
"Perhaps OTUB2 can activate the Akt pathway on its own without requiring KRT80?"
35110531
sparser
"MKN45 cells express a high level of OTUB2 but very little Ki67 and p-Akt (Thr308), indicating that OTUB2 does not activate the Akt pathway on its own, but via KRT80."
35110531
sparser
"As mentioned above, OTUB2 can stably activate the NF-kappaB pathway through K48 type deubiquitination of TRAF6 and maintenance of phosphorylated p65, resulting in pathological manifestations of cancer."
35309903
sparser
"Besides that, OTUB2 activates the Akt pathway, suggesting that it may be a novel therapeutic and prognostic target in GC."
35110531
OTUB2 affects lactate
| 1 3
OTUB2 activates lactate. 4 / 4
| 1 3
eidos
"Moreover , OTUB2 depletion reduces glucose consumption , lactate production , and cellular ATP production ."
34671086
reach
"As expected, we verified that OTUB2 overexpression increased ECAR, glucose uptake, and lactate production, while knockdown of OTUB2 impaired the aerobic glycolytic phenotype in different NSCLC cell lines."
30662561
reach
"Moreover, OTUB2 depletion reduces glucose consumption, lactate production, and cellular ATP production."
34671086
reach
"Conversely, OTUB2 overexpression substantially enhanced glycolytic capability, glucose uptake and extracellular lactate production in XL-2 and H292 cells."
30662561
OTUB2 affects UBC
4 |
UBC binds OTUB2. 4 / 4
4 |
biogrid
No evidence text available
25590432
biogrid
No evidence text available
23827681
biogrid
No evidence text available
25590432
biogrid
No evidence text available
18954305
OTUB2 affects PJA1
1 | 3
OTUB2 activates PJA1.
| 3
OTUB2 activates PJA1. 3 / 3
| 3
reach
"Mechanistically, it was found that OTUB2 promoted the stabilization of PJA1 by deubiquitylation, based on immunoprecipitation (IP) and cycloheximide (CHX) assays."
35611163
reach
"Moreover, the suppressive effects of OTUB2 depletion on the malignant phenotypes of HCC cells could be reversed by overexpressing PJA1."
35611163
reach
"In conclusion, our study indicated that OTUB2 could promote the malignant proliferation and migration of HCC cells by increasing the stability of PJA1 via deubiquitylation."
35611163
OTUB2 binds PJA1.
1 |
PJA1 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
OTUB2 affects Neoplasm Metastasis
| 1 3
reach
"Functionally, the overexpression of OTUB2 could promote malignant proliferation and metastasis of HCC cells, while knockdown of OTUB2 exerted the opposite results."
35611163
eidos
"OTUB2 was reported to enhance metastasis through Hippo-independent activation of YAP / TAZ signaling , which could stabilize YAP / TAZ by deubiquitination [ 37 ] ."
34315490
reach
"OTUB2 Promotes Cancer Metastasis via Hippo Independent Activation of YAP and TAZ."
30472188
reach
"OTUB2 was reported to enhance metastasis through Hippo-independent activation of YAP/TAZ signaling, which could stabilize YAP/TAZ by deubiquitination [37]."
34315490
reach
"In contrast, stable overexpression of OTUB2 significantly increased the invasion and migratory abilities of XL-2 and H292 cells."
30662561
reach
"We also confirmed that OTUB2 enhanced the proliferation, migration, and invasion abilities of NSCLC cells In vitro."
30662561
reach
"The overexpression of OTUB2 promoted glycolysis and induced the proliferation, migration, and invasion of endometrial cancer cells."
36316812
reach
"Moreover, knockdown of OTUB2 significantly suppressed the invasion and migration abilities of A549 and H1299 cells."
30662561
OTUB2 affects NSCLC
| 4
OTUB2 activates NSCLC. 4 / 4
| 4
reach
"More importantly, OTUB2 promoted NSCLC progression, which was largely dependent on the direct binding to and deubiquitination of U2AF2, at least in NSCLC cells."
30662561
reach
"To investigate the functional roles of U2AF2 in OTUB2 mediated NSCLC progression, we knocked down endogenous U2AF2 via two independent siRNAs in A549 and H1299 cells."
30662561
reach
"Our current findings suggest that OTUB2 promotes NSCLC progression, which is largely dependent on U2AF2, at least in NSCLC cells."
30662561
reach
"Next, to elucidate the underlying mechanism by which OTUB2 promotes NSCLC progression, a co-immunoprecipitation assay using antibodies against HA was performed in both 293T cells transfected with HA tagged OTUB2 and control cells."
30662561
reach
"Thus, the RNF8-RNF168 axis primarily suppresses HR and promotes non-HR-type DSB repair, e.g. NHEJ, and OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR."
26983989
reach
"OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR [XREF_BIBR, XREF_BIBR]."
30831436
reach
"Taking these findings together, we propose a model whereby OTUB2 inhibits excessive DSB-end protection and allows the initiation of HR by properly regulating the accumulation of RAP80 and 53BP1 at DSB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
OTUB2 affects glucose
| 3
OTUB2 activates glucose. 3 / 3
| 3
reach
"Moreover, OTUB2 depletion reduces glucose consumption, lactate production, and cellular ATP production."
34671086
reach
"As expected, we verified that OTUB2 overexpression increased ECAR, glucose uptake, and lactate production, while knockdown of OTUB2 impaired the aerobic glycolytic phenotype in different NSCLC cell lines."
30662561
reach
"Conversely, OTUB2 overexpression substantially enhanced glycolytic capability, glucose uptake and extracellular lactate production in XL-2 and H292 cells."
30662561
OTUB2 affects cell growth
| 3
OTUB2 activates cell growth.
| 2
OTUB2 activates cell growth. 2 / 2
| 2
reach
"At the cellular level, knockdown of OTUB2 markedly inhibited liver cancer cell growth."
32003539
reach
"Our further investigations revealed that knockdown of OTUB2 significantly suppressed NF-kappaB-driving luciferase activity, and markedly inhibited the phosphorylation of NF-kappaB p65 in liver cancer cells, which indicated that OTUB2 mediated liver cancer cell growth by regulating NF-kappaB signaling."
32003539
OTUB2 inhibits cell growth.
| 1
OTUB2 inhibits cell growth. 1 / 1
| 1
reach
"Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-kappaB signaling."
32003539
OTUB2 affects YAP1
| 1 2
OTUB2 binds YAP1.
| 2
YAP1 binds OTUB2. 2 / 2
| 2
sparser
"Not limited to cancer, the latest research has shown that pantoprazole promotes the degradation of YAP and finally blocks the progress of liver fibrosis by breaking the interaction between OTUB2 and YAP, which indirectly demonstrates that OTUB2 contributes to the progression of liver fibrosis ( xref )."
35309903
sparser
"Additionally, we showed that PPZ destabilized YAP by disrupting the interaction between a deubiquitinating enzyme OTUB2 and YAP, and subsequently blocked the progression of hepatic fibrosis."
34465912
OTUB2 inhibits YAP1.
| 1
OTUB2 inhibits YAP1. 1 / 1
| 1
reach
"OTUB2 knockdown in ESCC cell lines suppressed YAP1/TAZ signaling."
35850645
OTUB2 affects UIMC1
| 3
OTUB2 inhibits UIMC1. 3 / 3
| 3
reach
"Taking these findings together, we propose a model whereby OTUB2 inhibits excessive DSB-end protection and allows the initiation of HR by properly regulating the accumulation of RAP80 and 53BP1 at DSB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
reach
"OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR [XREF_BIBR, XREF_BIBR]."
30831436
reach
"Thus, the RNF8-RNF168 axis primarily suppresses HR and promotes non-HR-type DSB repair, e.g. NHEJ, and OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR."
26983989
OTUB2 affects UBE2N
1 | 2
OTUB2 inhibits UBE2N.
| 2
OTUB2 inhibits UBE2N. 2 / 2
| 2
reach
"These residues are important for OTUB1 inhibition of E2 activity 4 and are absent in OTUB2, which does not inhibit UBC13 4."
22367539
reach
"Interestingly, the corresponding residue is a glutamic acid in OTUB2, which lacks an N-terminal arm and does not inhibit UBC13 4."
22367539
OTUB2 binds UBE2N.
1 |
UBE2N binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
20725033
OTUB2 affects TP53BP1
| 3
OTUB2 inhibits TP53BP1. 3 / 3
| 3
reach
"OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR [XREF_BIBR, XREF_BIBR]."
30831436
reach
"Taking these findings together, we propose a model whereby OTUB2 inhibits excessive DSB-end protection and allows the initiation of HR by properly regulating the accumulation of RAP80 and 53BP1 at DSB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
reach
"Thus, the RNF8-RNF168 axis primarily suppresses HR and promotes non-HR-type DSB repair, e.g. NHEJ, and OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR."
26983989
OTUB2 affects TAZ
| 3
OTUB2 activates TAZ. 3 / 3
| 3
reach
"OTUB2 knockdown in ESCC cell lines suppressed YAP1/TAZ signaling."
35850645
reach
"OTUB2 Promotes Cancer Metastasis via Hippo Independent Activation of YAP and TAZ."
30472188
reach
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP and TAZ."
30472188
OTUB2 affects PGK1
| 1 2
OTUB2 binds PGK1.
| 2
OTUB2 binds U2AF2 and PGK1. 2 / 2
| 2
sparser
"High expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
sparser
"In addition, our results suggest that high expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
OTUB2 increases the amount of PGK1.
| 1
Modified OTUB2 increases the amount of PGK1. 1 / 1
| 1
reach
"Overexpression of OTUB2 upregulated the expression of PFKL and PGK1 in H292 cells and upregulated the expression of HK2, PFKL, PGK1, and PGAM1 in XL-2 cells."
30662561
OTUB2 affects MYC
| 3
OTUB2 activates MYC.
| 2
OTUB2 activates MYC. 2 / 2
| 2
reach
"OTUB2 may stimulate the Warburg effect by regulating HIF1a and c-Myc in NSCLC cells."
30662561
reach
"Collectively, these data indicate that OTUB2 promotes the Warburg effect by modulating HIF1a and c-Myc."
30662561
OTUB2 increases the amount of MYC.
| 1
OTUB2 increases the amount of MYC. 1 / 1
| 1
reach
"Moreover, it was very intriguing for us to show that OTUB2 promoted the protein expression of HIF1a and c-Myc and induced activation of the AKT and mTOR pathway."
30662561
OTUB2 affects IRF3
| 2
OTUB2 inhibits IRF3. 2 / 3
| 2
reach
"Overexpression of OTUB1 and OTUB2 inhibited virus induced activation of IRF3 and NF-kappaB, transcription of the IFNB1 gene as well as cellular antiviral response, whereas knockdown of OTUB1 and OTUB2 had opposite effects."
19996094
reach
"[172] Because various components are involved in virus induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG-I-, MDA5-, and MAVS mediated but not TBK1- and IRF3 mediated signaling."
33511009
OTUB2 affects HIF1A
| 3
OTUB2 activates HIF1A.
| 2
OTUB2 activates HIF1A. 2 / 2
| 2
reach
"Collectively, these data indicate that OTUB2 promotes the Warburg effect by modulating HIF1a and c-Myc."
30662561
reach
"OTUB2 may stimulate the Warburg effect by regulating HIF1a and c-Myc in NSCLC cells."
30662561
OTUB2 increases the amount of HIF1A.
| 1
OTUB2 increases the amount of HIF1A. 1 / 1
| 1
reach
"Moreover, it was very intriguing for us to show that OTUB2 promoted the protein expression of HIF1a and c-Myc and induced activation of the AKT and mTOR pathway."
30662561
OTUB2 affects Cell Survival
| 1 2
OTUB2 activates Cell Survival. 3 / 3
| 1 2
reach
"Cell Counting Kit-8 and flow cytometry assay results revealed that overexpression of OTUB2 enhanced cell viability of endometrial cancer cells, while knockdown of OTUB2 inhibited cell viability."
32830515
eidos
"Cell Counting Kit-8 and flow cytometry assay results revealed that overexpression of OTUB2 enhanced cell viability of endometrial cancer cells , while knockdown of OTUB2 inhibited cell viability ."
32830515
reach
"Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets."
23515685
OTUB2 affects CTNNB1
| 1 2
OTUB2 inhibits CTNNB1.
| 1
OTUB2 inhibits CTNNB1. 1 / 1
| 1
reach
"OTUB2 inhibits the lysosomal degradation of CTNNB1 by interacting with TRAF6 and thus regulates the progression of iCCA through ZEB1."
36858343
OTUB2 increases the amount of CTNNB1.
| 1
OTUB2 increases the amount of CTNNB1. 1 / 1
| 1
reach
"Mechanistically, OTUB2 promotes CTNNB1 expression by interacting with the E3 ligase TRAF6."
36858343
OTUB2 activates CTNNB1.
| 1
OTUB2 activates CTNNB1. 1 / 1
| 1
eidos
"Mechanistically , OTUB2 promotes CTNNB1 expression by interacting with the E3 ligase TRAF6 ."
36858343
L3MBTL1 affects OTUB2
| 3
L3MBTL1 binds OTUB2.
| 2
L3MBTL1 binds OTUB2. 2 / 2
| 2
reach
"These data suggest that the interaction between OTUB2 and L3MBTL1 is constitutive rather than DNA damage dependent.Next, we investigated whether OTUB2 could deubiquitinate L3MBTL1 in vivo."
24560272
reach
"Therefore, we focused on L3MBTL1 and asked whether OTUB2 prevented RNF8 mediated ubiquitination of L3MBTL1.First, to confirm whether OTUB2 interacts with L3MBTL1, we performed a coimmunoprecipitation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
L3MBTL1 inhibits OTUB2.
| 1
L3MBTL1 inhibits OTUB2. 1 / 1
| 1
reach
"In contrast, when OTUB2 was depleted by siRNA, control shRNA expressing cells and L3MBTL1 specific shRNA expressing cells exhibited similar frequencies of cells with large 53BP1 foci."
24560272
GLI2 affects OTUB2
| 1 2
OTUB2 binds GLI2. 3 / 3
| 1 2
reach
"The authors found that OTUB2 formed a complex with Gli2 and promoted Gli2 deubiquitination both in vitro and in vivo."
| PMC
sparser
"The authors found that OTUB2 formed a complex with Gli2 and promoted Gli2 deubiquitination both in vitro and in vivo."
| PMC
sparser
"Meanwhile, the interaction between OTUB2 and Gli2 was determined by immunoprecipitation ( xref )."
35309903
(+)-JQ1 compound affects OTUB2
3 |
(+)-JQ1 compound decreases the amount of OTUB2. 3 / 3
3 |
ctd
No evidence text available
27432991
ctd
No evidence text available
25307878
ctd
No evidence text available
26752646
Silicon dioxide affects OTUB2
2 |
Silicon dioxide increases the amount of OTUB2. 2 / 2
2 |
ctd
No evidence text available
25895662
ctd
No evidence text available
25351596
Ligand affects OTUB2
| 2
Ligand binds OTUB2. 2 / 2
| 2
reach
"Structural parameters and ligand dynamics are in excellent agreement with the ligand-bound OTUB2 crystal structures."
34071582
reach
"The protein RMSD between the apo and the ligand-bound OTUB2 structures was 0."
34071582
Hsa-miR-6856-3p affects OTUB2
2 |
Hsa-miR-6856-3p decreases the amount of OTUB2. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22012620
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-629-3p affects OTUB2
2 |
Hsa-miR-629-3p decreases the amount of OTUB2. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
19536157
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4279 affects OTUB2
2 |
Hsa-miR-4279 decreases the amount of OTUB2. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
19536157
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-1264 affects OTUB2
2 |
Hsa-miR-1264 decreases the amount of OTUB2. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
19536157
biopax:mirtarbase
No evidence text available
23824327
Bisphenol A affects OTUB2
2 |
Bisphenol A methylates OTUB2.
1 |
Bisphenol A methylates OTUB2. 1 / 1
1 |
ctd
No evidence text available
28505145
Bisphenol A increases the amount of OTUB2.
1 |
Bisphenol A increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
26496021
Benzo[a]pyrene affects OTUB2
2 |
Benzo[a]pyrene increases the amount of OTUB2. 2 / 2
2 |
ctd
No evidence text available
20106945
ctd
No evidence text available
21632981
Aflatoxin B1 affects OTUB2
2 |
Aflatoxin B1 increases the amount of OTUB2.
1 |
Aflatoxin B1 increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
21641981
Aflatoxin B1 decreases the amount of OTUB2.
1 |
Aflatoxin B1 decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
19770486
YAP1 affects OTUB2
| 2
YAP1 binds OTUB2. 2 / 2
| 2
sparser
"Not limited to cancer, the latest research has shown that pantoprazole promotes the degradation of YAP and finally blocks the progress of liver fibrosis by breaking the interaction between OTUB2 and YAP, which indirectly demonstrates that OTUB2 contributes to the progression of liver fibrosis ( xref )."
35309903
sparser
"Additionally, we showed that PPZ destabilized YAP by disrupting the interaction between a deubiquitinating enzyme OTUB2 and YAP, and subsequently blocked the progression of hepatic fibrosis."
34465912
UB chains affects OTUB2
| 2
OTUB2 binds UB chains. 2 / 2
| 2
reach
"A. thaliana OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
reach
"Among the eleven A. thaliana OTU DUBs examined, we found that OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
U2AF2 affects PGK1
| 2
OTUB2 binds U2AF2 and PGK1. 2 / 2
| 2
sparser
"High expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
sparser
"In addition, our results suggest that high expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
TRIM54 affects OTUB2
2 |
TRIM54 binds OTUB2. 2 / 2
2 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
22626734
TRAF6 affects TRAF3
| 2
TRAF3 binds TRAF6, OTUB2, and OTUB1. 2 / 2
| 2
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains.[ 172 ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
POLH affects OTUB2
| 1 1
OTUB2 binds POLH. 2 / 2
| 1 1
reach
"XREF_BIBR In addition, a negative genetic interaction between OTU2 and RAD30, which encodes the translesion DNA synthesis (TLS) polymerase eta in yeast, was also reported."
30429995
sparser
"OTU2 has been previously linked to DNA damage response due to an increase in its protein level upon MMS-induced DNA damage. xref In another study, knockout of OTU2 in yeast cells led to an increased expression of a number of DNA repair proteins. xref In addition, a negative genetic interaction between OTU2 and RAD30, which encodes the translesion DNA synthesis (TLS) polymerase η in yeast, was also reported. xref Our result suggested a potential connection of OTU2 to DNA damage response, particularly PCNA deubiquitination."
30429995
PGK1 affects U2AF2
| 2
OTUB2 binds U2AF2 and PGK1. 2 / 2
| 2
sparser
"High expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
sparser
"In addition, our results suggest that high expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
OTUB2 affects ligand
| 2
Ligand binds OTUB2. 2 / 2
| 2
reach
"Structural parameters and ligand dynamics are in excellent agreement with the ligand-bound OTUB2 crystal structures."
34071582
reach
"The protein RMSD between the apo and the ligand-bound OTUB2 structures was 0."
34071582
reach
"The overexpression of OTUB2 promoted glycolysis and induced the proliferation, migration, and invasion of endometrial cancer cells."
36316812
reach
"Here we demonstrate that OTUB2, an OTU deubiquitinase, is upregulated in colorectal cancer (CRC) and exacerbates the progression of CRC through modulating the aerobic glycolysis."
34671086
OTUB2 affects eS7A
| 2
OTUB2 deubiquitinates eS7A on S40. 1 / 1
| 1
reach
"To examine whether Otu2 deubiquitinates eS7A directly in the 40S ribosome, recombinant His Otu2 was added to mono- and di ubiquitinated eS7A-3HA prepared from 40S ribosome fractions of otu2Deltaubp3DeltaeS7A-3HA cells."
33665564
OTUB2 deubiquitinates eS7A. 1 / 1
| 1
reach
"Otu2 and Ubp3 deubiquitinate eS7A in the distinct ribosome complexes."
33665564
OTUB2 affects UB chains
| 2
OTUB2 binds UB chains. 2 / 2
| 2
reach
"A. thaliana OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
reach
"Among the eleven A. thaliana OTU DUBs examined, we found that OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
OTUB2 affects TRIM54
2 |
TRIM54 binds OTUB2. 2 / 2
2 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
22626734
OTUB2 affects STAT1
| 2
OTUB2 phosphorylates STAT1.
| 1
OTUB2 leads to the phosphorylation of STAT1. 1 / 1
| 1
reach
"Mechanistically, OTUB2 promotes the deubiquitination and phosphorylation of signal transducer and activator of transcription 1 (STAT1) and subsequently regulates the transcription of calmodulin-like protein 3 (CALML3)."
36288705
OTUB2 deubiquitinates STAT1.
| 1
OTUB2 leads to the deubiquitination of STAT1. 1 / 1
| 1
reach
"Mechanistically, OTUB2 promotes the deubiquitination and phosphorylation of signal transducer and activator of transcription 1 (STAT1) and subsequently regulates the transcription of calmodulin-like protein 3 (CALML3)."
36288705
OTUB2 affects RUNX2
| 2
OTUB2 increases the amount of RUNX2.
| 1
OTUB2 increases the amount of RUNX2. 1 / 1
| 1
reach
"We also found that OTUB2 knockdown suppressed the ALP activity and the expression of the common markers BMP2 and RUNX2 during osteogenesis of MSCs in response to Shh and Smo agonists, which indicated OTUB2 may have effect on osteogenic differentiation by regulating Hh signaling."
30241937
OTUB2 decreases the amount of RUNX2.
| 1
OTUB2 decreases the amount of RUNX2. 1 / 1
| 1
reach
"OTUB2 knockdown suppressed the alkaline phosphatase activity and the expression of the common osteogenic markers BMP2 and RUNX2 during osteogenesis of mesenchymal stem cells in response to Shh and Smo agonists, suggesting that OTUB2 may play a role in osteogenic differentiation by regulating Hh signaling [64]."
| PMC
OTUB2 affects RPS7
| 2
OTUB2 deubiquitinates RPS7. 2 / 2
| 2
reach
"Otu2 deubiquitinates eS7 in order to promote dissociation of the small ribosomal subunit from the mRNA upon completion of translation (129)."
34391779
reach
"In actively translating 80S ribosomes the ribosomal protein eS7 of the 40S subunit is monoubiquitinated by the E3 ligase Not4 and deubiquitinated by Otu2 upon ribosomal subunit recycling."
37169754
OTUB2 affects POLH
| 1 1
OTUB2 binds POLH. 2 / 2
| 1 1
reach
"XREF_BIBR In addition, a negative genetic interaction between OTU2 and RAD30, which encodes the translesion DNA synthesis (TLS) polymerase eta in yeast, was also reported."
30429995
sparser
"OTU2 has been previously linked to DNA damage response due to an increase in its protein level upon MMS-induced DNA damage. xref In another study, knockout of OTU2 in yeast cells led to an increased expression of a number of DNA repair proteins. xref In addition, a negative genetic interaction between OTU2 and RAD30, which encodes the translesion DNA synthesis (TLS) polymerase η in yeast, was also reported. xref Our result suggested a potential connection of OTU2 to DNA damage response, particularly PCNA deubiquitination."
30429995
OTUB2 affects PGK1, and U2AF2
| 2
OTUB2 binds U2AF2 and PGK1. 2 / 2
| 2
sparser
"High expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
sparser
"In addition, our results suggest that high expression of OTUB2, U2AF2 and PGK1 is significantly associated with worse prognosis in NSCLC patients."
30662561
OTUB2 affects OTUB2
| 2
OTUB2 deubiquitinates OTUB2.
| 1
OTUB2 leads to the deubiquitination of OTUB2. 1 / 1
| 1
reach
"Because the accumulation of RNF168 at DSBs requires the E3 ubiquitin ligase activity of RNF8 and the accumulation of 53BP1, RAP80, and BRCA1 requires recruitment of RNF168 to DSBs (Doil et al., 2009; [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
OTUB2 decreases the amount of OTUB2.
| 1
OTUB2 decreases the amount of OTUB2. 1 / 1
| 1
reach
"Cell lines with the highest expression of OTUB2 were transfected with lentivirus to knockdown OTUB2 levels."
35850645
OTUB2 affects MTOR
| 2
OTUB2 inhibits MTOR.
| 1
OTUB2 inhibits MTOR. 1 / 1
| 1
reach
"In addition, OTUB2 inhibition deactivated the AKT/mTOR signaling in CC cells."
37334762
OTUB2 activates MTOR.
| 1
OTUB2 activates MTOR. 1 / 1
| 1
reach
"The phosphorylation levels of mTOR and AKT were increased, indicating that the mTOR pathway may be activated by OTUB2."
30662561
OTUB2 affects MAVS
1 | 1
OTUB2 inhibits MAVS.
| 1
OTUB2 inhibits MAVS. 1 / 1
| 1
reach
"[172] Because various components are involved in virus induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG-I-, MDA5-, and MAVS mediated but not TBK1- and IRF3 mediated signaling."
33511009
OTUB2 binds MAVS.
1 |
OTUB2 binds MAVS. 1 / 1
1 |
biogrid
No evidence text available
19996094
OTUB2 affects MAGEA11
1 1 |
OTUB2 binds MAGEA11. 2 / 2
1 1 |
biogrid
No evidence text available
16189514
hprd
No evidence text available
16189514
OTUB2 affects IFN-I
| 2
OTUB2 inhibits IFN-I.
| 1
OTUB2 inhibits IFN-I. 1 / 1
| 1
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
OTUB2 activates IFN-I.
| 1
OTUB2 activates IFN-I. 1 / 1
| 1
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
OTUB2 affects FAM168A
2 |
OTUB2 binds FAM168A. 2 / 2
2 |
biogrid
No evidence text available
21516116
biogrid
No evidence text available
25416956
OTUB2 affects FAM126A
| 2
OTUB2 activates FAM126A. 2 / 2
| 2
reach
"In conclusion, our study indicated that OTUB2 could promote the malignant proliferation and migration of HCC cells by increasing the stability of PJA1 via deubiquitylation."
35611163
reach
"Functionally, the overexpression of OTUB2 could promote malignant proliferation and metastasis of HCC cells, while knockdown of OTUB2 exerted the opposite results."
35611163
OTUB2 inhibits DNA damage response, detection of DNA damage. 2 / 2
| 2
reach
"Therefore, we excluded the off-target effects of the siRNA and confirmed that OTUB2 indeed suppressed the DDR in a DUB activity dependent manner."
24560272
reach
"These data indicate that the mechanism by which OTUB2 inhibits the DDR is through its deubiquitination activity, which is different from that of OTUB1.Next, we sought to pinpoint the step of DDR signa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
OTUB2 affects CC
| 2
OTUB2 inhibits CC.
| 1
OTUB2 inhibits CC. 1 / 1
| 1
reach
"In addition, OTUB2 inhibition deactivated the AKT/mTOR signaling in CC cells."
37334762
OTUB2 activates CC.
| 1
OTUB2 activates CC. 1 / 1
| 1
reach
"As indicated by CCK-8, Transwell, and flow cytometry results, OTUB2 silencing attenuated proliferative and metastatic capacities of CC cells but promoted CC cell apoptosis."
37334762
OTUB2 affects BMP2
| 2
OTUB2 increases the amount of BMP2. 2 / 2
| 2
reach
"We also found that OTUB2 knockdown suppressed the ALP activity and the expression of the common markers BMP2 and RUNX2 during osteogenesis of MSCs in response to Shh and Smo agonists, which indicated OTUB2 may have effect on osteogenic differentiation by regulating Hh signaling."
30241937
reach
"OTUB2 knockdown suppressed the alkaline phosphatase activity and the expression of the common osteogenic markers BMP2 and RUNX2 during osteogenesis of mesenchymal stem cells in response to Shh and Smo agonists, suggesting that OTUB2 may play a role in osteogenic differentiation by regulating Hh signaling [64]."
| PMC
OTUB1 affects TRAF6
| 2
TRAF3 binds TRAF6, OTUB2, and OTUB1. 2 / 2
| 2
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains.[ 172 ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63‐linked polyubiquitin chains. [ xref ] Because various components are involved in virus‐induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG‐I‐, MDA5‐, and MAVS‐mediated but not TBK1‐ and IRF3‐mediated signaling."
33511009
ctd
No evidence text available
28801915
N-methyl-4-phenylpyridinium increases the amount of OTUB2.
1 |
N-methyl-4-phenylpyridinium increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
28801915
MAGEA11 affects OTUB2
1 1 |
OTUB2 binds MAGEA11. 2 / 2
1 1 |
biogrid
No evidence text available
16189514
hprd
No evidence text available
16189514
FAM168A affects OTUB2
2 |
OTUB2 binds FAM168A. 2 / 2
2 |
biogrid
No evidence text available
21516116
biogrid
No evidence text available
25416956
Dietary Fats affects OTUB2
2 |
Dietary Fats increases the amount of OTUB2.
1 |
Dietary Fats increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
18042831
Dietary Fats decreases the amount of OTUB2.
1 |
Dietary Fats decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25016146
Vorinostat affects OTUB2
1 |
Vorinostat decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
27188386
Vanadium oxoanion affects OTUB2
1 |
Vanadium oxoanion increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
22714537
Valdecoxib affects OTUB2
1 |
Valdecoxib decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
24136188
Urethane affects OTUB2
1 |
Urethane decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
28818685
Triphenyl phosphate increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
30589522
Trimellitic anhydride increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
19042947
Topotecan affects OTUB2
1 |
Topotecan decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25729387
Titanium dioxide affects OTUB2
1 |
Titanium dioxide decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
29264374
Thiocyanate affects OTUB2
| 1
Thiocyanate activates OTUB2. 1 / 1
| 1
reach
"To re-examine the ability of OTUB2 to inhibit 53BP1 foci formation, HeLa cells were transiently transfected with Flag-OTUB2 expression vectors, treated with NCS, and then subjected to Flag and 53BP1 i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
Thioacetamide affects OTUB2
1 |
Thioacetamide decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
23411599
Thimerosal affects OTUB2
1 |
Thimerosal decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
27188386
Testosterone affects OTUB2
1 |
Testosterone increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
26496021
Tamoxifen affects OTUB2
1 |
Tamoxifen decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
19059307
Sulfate affects OTUB2
| 1
Sulfate activates OTUB2. 1 / 1
| 1
reach
"High methane and sulfate supported the growth of anaerobic methane oxidizers and sulfate reducing bacteria as well as the high abundance of Aigarchaeota (OTU2)."
32153535
Sodium dichromate affects OTUB2
1 |
Sodium dichromate decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25993096
Smo-1 affects OTUB2
| 1
OTUB2 binds smo-1. 1 / 1
| 1
sparser
"Sumoylated OTUB2 interacts specifically with yet-unidentified sumo interaction motifs (SIMs) in WW domain-containing transcription factor (TAZ) and Yes-associated protein (YAP) to regulate protein activity and TAZ/YAP polyubiquitination in a Hippo-independent manner."
35110531
Rotenone affects OTUB2
1 |
Rotenone decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
28374803
Raloxifene hydrochloride decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
19059307
Quercetin affects OTUB2
1 |
Quercetin increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
21632981
Pyruvate kinase affects OTUB2
| 1
OTUB2 binds pyruvate kinase. 1 / 1
| 1
sparser
"Mechanistically, OTUB2 directly interacts with pyruvate kinase M2 (PKM2) and inhibits its ubiquitination by blocking the interaction between PKM2 and its ubiquitin E3 ligase Parkin, thereby enhancing PKM2 activity and promoting glycolysis."
34671086
Pirinixic acid affects OTUB2
1 |
Pirinixic acid decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
23811191
Phorbol 13-acetate 12-myristate increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25613284
Oxaliplatin affects OTUB2
1 |
Oxaliplatin decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25729387
Ormosil affects OTUB2
1 |
Ormosil increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
24888373
Methylmercury compound decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
22129749
Methapyrilene affects OTUB2
1 |
Methapyrilene methylates OTUB2. 1 / 1
1 |
ctd
No evidence text available
30157460
Methane affects OTUB2
| 1
Methane activates OTUB2. 1 / 1
| 1
reach
"High methane and sulfate supported the growth of anaerobic methane oxidizers and sulfate reducing bacteria as well as the high abundance of Aigarchaeota (OTU2)."
32153535
Metformin affects OTUB2
1 |
Metformin increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
31324951
Lucanthone affects OTUB2
1 |
Lucanthone increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
21148553
Jinfukang affects OTUB2
1 |
Jinfukang increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
27392435
Isotretinoin affects OTUB2
1 |
Isotretinoin decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
20436886
Ionomycin affects OTUB2
1 |
Ionomycin increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25613284
Indometacin affects OTUB2
1 |
Indometacin increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
28628672
Hsa-miR-6887-3p affects OTUB2
1 |
Hsa-miR-6887-3p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6769a-3p affects OTUB2
1 |
Hsa-miR-6769a-3p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-5687 affects OTUB2
1 |
Hsa-miR-5687 decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-4773 affects OTUB2
1 |
Hsa-miR-4773 decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-4682 affects OTUB2
1 |
Hsa-miR-4682 decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4424 affects OTUB2
1 |
Hsa-miR-4424 decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4420 affects OTUB2
1 |
Hsa-miR-4420 decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4313 affects OTUB2
1 |
Hsa-miR-4313 decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-3943 affects OTUB2
1 |
Hsa-miR-3943 decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-3680-5p affects OTUB2
1 |
Hsa-miR-3680-5p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-335-5p affects OTUB2
1 |
Hsa-miR-335-5p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Hsa-miR-3186-5p affects OTUB2
1 |
Hsa-miR-3186-5p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23708386
Hsa-miR-215-5p affects OTUB2
1 |
Hsa-miR-215-5p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-192-5p affects OTUB2
1 |
Hsa-miR-192-5p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-181b-3p affects OTUB2
1 |
Hsa-miR-181b-3p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-181b-2-3p affects OTUB2
1 |
Hsa-miR-181b-2-3p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-1304-3p affects OTUB2
1 |
Hsa-miR-1304-3p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-125a-5p affects OTUB2
1 |
Hsa-miR-125a-5p decreases the amount of OTUB2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hexabromocyclododecane decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
29177809
Genistein affects OTUB2
1 |
Genistein increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
20884965
Folic acid affects OTUB2
1 |
Folic acid methylates OTUB2. 1 / 1
1 |
ctd
No evidence text available
20938992
Ethylene glycol affects OTUB2
1 |
Ethylene glycol increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
24888373
Dorsomorphin affects OTUB2
1 |
Dorsomorphin decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
27188386
Dibutyl phthalate affects OTUB2
1 |
Dibutyl phthalate decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
21266533
Dexamethasone affects OTUB2
1 |
Dexamethasone increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
28628672
Cypermethrin affects OTUB2
1 |
Cypermethrin increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
29020013
Crocidolite asbestos increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25351596
Cisplatin affects OTUB2
1 |
Cisplatin increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
27392435
Choline affects OTUB2
1 |
Choline methylates OTUB2. 1 / 1
1 |
ctd
No evidence text available
20938992
Casticin affects OTUB2
1 |
Casticin decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
28444820
Bisphenol F affects OTUB2
1 |
Bisphenol F increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
28628672
Benzo[e]pyrene affects OTUB2
1 |
Benzo[e]pyrene methylates OTUB2. 1 / 1
1 |
ctd
No evidence text available
30157460
Aluminium atom affects OTUB2
1 |
Aluminium atom decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
21298039
Aflatoxin B2 affects OTUB2
1 |
Aflatoxin B2 methylates OTUB2. 1 / 1
1 |
ctd
No evidence text available
30157460
Acetamide affects OTUB2
1 |
Acetamide decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
31881176
USP32P2 affects OTUB2
1 |
OTUB2 binds USP32P2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP28 affects OTUB2
1 |
USP28 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects OTUB2
1 |
USP21 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
UBE2N affects OTUB2
1 |
UBE2N binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
20725033
TRIP6 affects OTUB2
1 |
TRIP6 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
25416956
TRIM8 affects OTUB2
1 |
TRIM8 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM63 affects OTUB2
1 |
TRIM63 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
TRIM55 affects OTUB2
1 |
TRIM55 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
TRIM5 affects OTUB2
1 |
TRIM5 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM39 affects OTUB2
1 |
TRIM39 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM27 affects OTUB2
1 |
OTUB2 binds TRIM27. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM26 affects OTUB2
1 |
TRIM26 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM25 affects OTUB2
1 |
TRIM25 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM2 affects OTUB2
1 |
TRIM2 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
TP53BP2 affects OTUB2
1 |
TP53BP2 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
25416956
Soot affects OTUB2
1 |
Soot decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
26551751
Soman affects OTUB2
1 |
Soman decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
19281266
SIAH1 affects OTUB2
1 |
SIAH1 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
25416956
SERPINB3 affects OTUB2
| 1
SERPINB3 methylates OTUB2. 1 / 1
| 1
reach
"We show that DNA hypermethylation of otubain 2 (OTUB2), a previously recognized oncogene, drives tongue and esophageal SCC initiation and drug resistance."
36288705
SAX affects OTUB2
| 1
SAX activates OTUB2. 1 / 1
| 1
reach
"FOS increased Ruminococcus2 OTU3 and Lactobacillus OTU37, SAX increased Bacteroides OTU2, and CAX increased Bacteroides OTU11."
28572676
RNF126 affects OTUB2
1 |
OTUB2 binds RNF126. 1 / 1
1 |
biogrid
No evidence text available
23105109
RFFL affects OTUB2
1 |
OTUB2 binds RFFL. 1 / 1
1 |
biogrid
No evidence text available
22626734
REL affects OTUB2
1 |
OTUB2 binds REL. 1 / 1
1 |
biogrid
No evidence text available
25416956
RBM15 affects OTUB2
| 1
RBM15 increases the amount of OTUB2. 1 / 1
| 1
reach
"Mechanistically, m 6 A RNA immunoprecipitation (Me-RIP) results showed that RBM15 inhibition reduced the m 6 A methylation level of OTUB2 in CC cells, leading to the decline of OTUB2 expression."
37334762
RBCK1 affects OTUB2
1 |
RBCK1 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
Palm Oil affects OTUB2
1 |
Palm Oil increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
18042831
PKM2/PI3K/AKT affects OTUB2
| 1
PKM2/PI3K/AKT increases the amount of OTUB2. 1 / 1
| 1
reach
"Importantly, inhibition of the PKM2/PI3K/AKT signaling pathway significantly reversed the promoting effect of OTUB2 overexpression on EC."
36316812
PJA1 affects OTUB2
1 |
PJA1 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
PAX4 affects OTUB2
1 |
PAX4 decreases the amount of OTUB2. 1 / 1
1 |
biopax:msigdb
No evidence text available
OTUB2 affects tumour gastric cancer
| 1
OTUB2 activates tumour gastric cancer. 1 / 1
| 1
eidos
"Correction : OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer ."
35440577
OTUB2 affects translation
| 1
OTUB2 inhibits translation. 1 / 1
| 1
reach
"These results suggest that the deletion of Otu2 does not cause abortive translation."
33665564
OTUB2 affects smo-1
| 1
OTUB2 binds smo-1. 1 / 1
| 1
sparser
"Sumoylated OTUB2 interacts specifically with yet-unidentified sumo interaction motifs (SIMs) in WW domain-containing transcription factor (TAZ) and Yes-associated protein (YAP) to regulate protein activity and TAZ/YAP polyubiquitination in a Hippo-independent manner."
35110531
OTUB2 affects replication
| 1
OTUB2 inhibits replication. 1 / 1
| 1
sparser
"Knockdown of OTUB1 and OTUB2 inhibited vesicular stomatitis virus (VSV) replication."
23151130
eidos
"OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer ."
32830515
OTUB2 affects pyruvate kinase
| 1
OTUB2 binds pyruvate kinase. 1 / 1
| 1
sparser
"Mechanistically, OTUB2 directly interacts with pyruvate kinase M2 (PKM2) and inhibits its ubiquitination by blocking the interaction between PKM2 and its ubiquitin E3 ligase Parkin, thereby enhancing PKM2 activity and promoting glycolysis."
34671086
OTUB2 affects polyubiquitin chains
| 1
OTUB2 activates polyubiquitin chains. 1 / 1
| 1
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
OTUB2 activates phosphatidylserine biosynthetic process. 1 / 1
| 1
reach
"OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis."
36288705
OTUB2 affects nuclear factor-kappaB
| 1
OTUB2 activates nuclear factor-kappaB. 1 / 1
| 1
reach
"OTUB2 knockdown increased caspase-3/7 activity in MIN6 cells and primary human islets and inhibited insulin secretion and increased nuclear factor-kappaB (NF-kappaB) activity both under basal conditions and following cytokine treatment."
23515685
OTUB2 affects inulin
| 1
OTUB2 activates inulin. 1 / 1
| 1
reach
"As shown in Additional file 2: Figure S1, OTU2 were rapidly increased after starting inulin feeding and showed significant compositional increment after 2 weeks of continuous inulin feeding (p values < 4E−02, Tukey’s HSD test)."
31969191
OTUB2 inhibits inflammatory response. 1 / 1
| 1
reach
"Consistent with this possibility, in depth taxonomic analysis of the 16S rDNA dataset revealed that OTU2, OTU6, and OTU24 decreased in their relative abundance with co-housing, indicating that these bacterial species might have promoted skin inflammation in ft/ft mice."
30240702
OTUB2 affects homologous recombination repair endometrial cancer
| 1
OTUB2 activates homologous recombination repair endometrial cancer. 1 / 1
| 1
eidos
"In conclusion , OTUB2 promoted homologous recombination repair in endometrial cancer via YAP / TAZ-mediated Rad51 expression , providing a potential therapeutic target for endometrial cancer ."
32830515
OTUB2 affects glucose consumption
| 1
OTUB2 activates glucose consumption. 1 / 1
| 1
eidos
"Moreover , OTUB2 depletion reduces glucose consumption , lactate production , and cellular ATP production ."
34671086
OTUB2 affects cellular ATP
| 1
OTUB2 activates cellular ATP. 1 / 1
| 1
eidos
"Moreover , OTUB2 depletion reduces glucose consumption , lactate production , and cellular ATP production ."
34671086
OTUB2 affects cell
| 1
OTUB2 activates cell. 1 / 1
| 1
eidos
"In addition , OTUB2 inhibition deactivated the AKT / mTOR signaling in CC cells ."
37334762
OTUB2 affects cell cycle
| 1
OTUB2 inhibits cell cycle. 1 / 1
| 1
reach
"A more detailed in silico gene analysis within this pathway disclosed that PAX4 induced the expression of both cell cycle activators such as CYCLIN A2, B2, D1 and D3, CMYC, HDAC and PCNA as well cell cycle inhibitors such as P21, P53, OTUB2 and ERRFI1 (XREF_TABLE)."
26503027
OTUB2 affects apoptotic process
| 1
reach
"As indicated by CCK-8, Transwell, and flow cytometry results, OTUB2 silencing attenuated proliferative and metastatic capacities of CC cells but promoted CC cell apoptosis."
37334762
OTUB2 affects activation
| 1
OTUB2 inhibits activation. 1 / 1
| 1
sparser
"Overexpression of OTUB1 and OTUB2 inhibited virus-induced activation of IRF3 and NF-kappaB, transcription of the IFNB1 gene as well as cellular antiviral response, whereas knockdown of OTUB1 and OTUB2 had opposite effects."
19996094
OTUB2 affects Yes-associated protein
| 1
OTUB2 activates Yes-associated protein. 1 / 1
| 1
eidos
"Mechanistically , OTUB2 could activate Yes-associated protein / transcriptional co-activator with PDZ-binding motif ( TAZ ) to promote homologous recombination repair via depletion of gammaH2AX ( phosphorylation of histone H2AX ) and accumulation of Rad51 ."
32830515
OTUB2 affects Ubiquitination
| 1
OTUB2 inhibits Ubiquitination. 1 / 1
| 1
eidos
"Mechanistically , OTUB2 directly interacts with pyruvate kinase M2 ( PKM2 ) and inhibits its ubiquitination by blocking the interaction between PKM2 and its ubiquitin E3 ligase Parkin , thereby enhancing PKM2 activity and promoting glycolysis ."
34671086
OTUB2 affects USP32P2
1 |
OTUB2 binds USP32P2. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUB2 affects USP28
1 |
USP28 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
OTUB2 affects USP21
1 |
USP21 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
OTUB2 affects TRIP6
1 |
TRIP6 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects TRIM8
1 |
TRIM8 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects TRIM63
1 |
TRIM63 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
OTUB2 affects TRIM55
1 |
TRIM55 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
OTUB2 affects TRIM5
1 |
TRIM5 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects TRIM39
1 |
TRIM39 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects TRIM27
1 |
OTUB2 binds TRIM27. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects TRIM26
1 |
TRIM26 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects TRIM25
1 |
TRIM25 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects TRIM2
1 |
TRIM2 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects TP53BP2
1 |
TP53BP2 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects TBK1
| 1
OTUB2 inhibits TBK1. 1 / 1
| 1
reach
"[172] Because various components are involved in virus induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG-I-, MDA5-, and MAVS mediated but not TBK1- and IRF3 mediated signaling."
33511009
OTUB2 affects Stomach Neoplasms
| 1
OTUB2 activates Stomach Neoplasms. 1 / 1
| 1
reach
"Knockdown of OTUB2 inhibited the proliferative capacity of GC cells in vitro and in vivo, although the proliferative capacity was restored upon re-supplementation with KRT80."
35110531
OTUB2 affects SIAH1
1 |
SIAH1 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects Renilla luciferase
| 1
OTUB2 activates Renilla luciferase. 1 / 1
| 1
reach
"However, the precise mechanism by which recombinant Otu2 upregulates the synthesis of Renilla luciferase (XREF_FIG B) remains unknown."
33665564
OTUB2 affects RNF168
| 1
OTUB2 inhibits RNF168. 1 / 1
| 1
reach
"On the other hand, we also found 13 DUBs that were recruited to DNA damage sites but gave only marginal DSB repair defects upon siRNA depletion, including OTUB1, a negative regulator of the UBE2N (UBC13) ubiquitin E2 enzyme 24, USP44 that is reported to antagonize RNF168 dependent ubiquitylation 25, and OTUB2 that functions in repair-pathway choice 26 (XREF_FIG, XREF_FIG, and XREF_FIG), suggesting that some of the additional DUBs we identified might be negative DDR regulators and/or be involved in repair-pathway choice."
25194926
OTUB2 affects RNF126
1 |
OTUB2 binds RNF126. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects RIG-I-, MDA5-,
| 1
OTUB2 inhibits RIG-I-, MDA5-,. 1 / 1
| 1
reach
"[172] Because various components are involved in virus induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG-I-, MDA5-, and MAVS mediated but not TBK1- and IRF3 mediated signaling."
33511009
OTUB2 affects RIG-I MDA5 MAVS-mediated TBK1 IRF3-mediated signaling
| 1
OTUB2 inhibits RIG-I MDA5 MAVS-mediated TBK1 IRF3-mediated signaling. 1 / 1
| 1
eidos
"] Because various components are involved in virus-induced signaling , biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG-I - , MDA5 - , and MAVS-mediated but not TBK1 - and IRF3-mediated signaling ."
33511009
OTUB2 affects RFFL
1 |
OTUB2 binds RFFL. 1 / 1
1 |
biogrid
No evidence text available
22626734
OTUB2 affects REL
1 |
OTUB2 binds REL. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects RBCK1
1 |
RBCK1 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
23105109
OTUB2 affects Protease
| 1
OTUB2 deubiquitinates Protease. 1 / 1
| 1
reach
"A second shared gene of interest is OTU2 that encodes a putative otubain related deubiquitylating protease XREF_BIBR, XREF_BIBR."
24009520
OTUB2 affects PKM
| 1
OTUB2 increases the amount of PKM. 1 / 1
| 1
reach
"In addition, the silencing of OTUB2 significantly suppressed the expression levels of PKM2."
36316812
OTUB2 affects PGAM1
| 1
Modified OTUB2 increases the amount of PGAM1. 1 / 1
| 1
reach
"Overexpression of OTUB2 upregulated the expression of PFKL and PGK1 in H292 cells and upregulated the expression of HK2, PFKL, PGK1, and PGAM1 in XL-2 cells."
30662561
OTUB2 affects PFKL
| 1
Modified OTUB2 increases the amount of PFKL. 1 / 1
| 1
reach
"Overexpression of OTUB2 upregulated the expression of PFKL and PGK1 in H292 cells and upregulated the expression of HK2, PFKL, PGK1, and PGAM1 in XL-2 cells."
30662561
OTUB2 affects Neoplasms
| 1
OTUB2 activates Neoplasms. 1 / 1
| 1
reach
"Furthermore, in vivo assays show that knockout of OTUB2 inhibits tumor growth in mice."
34671086
OTUB2 affects NMRAL1
1 |
OTUB2 binds NMRAL1. 1 / 1
1 |
biogrid
No evidence text available
24763515
OTUB2 affects NF-kappaB inhibitors
| 1
OTUB2 activates NF-kappaB inhibitors. 1 / 1
| 1
reach
"Additionally, we found that liver cancer cell lines harboring higher OTUB2 expression were more sensitive to NF-kappaB inhibitors, and overexpression of OTUB2 could significantly reduce the antitumor effects of NF-kappaB inhibitors in liver cancer cells."
32003539
OTUB2 affects Mice
| 1
OTUB2 activates Mice. 1 / 1
| 1
reach
"Furthermore, in vivo assays show that knockout of OTUB2 inhibits tumor growth in mice."
34671086
OTUB2 affects MID2
1 |
OTUB2 binds MID2. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects MID1
1 |
OTUB2 binds MID1. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects MGI.B
| 1
OTUB2 activates MGI.B. 1 / 1
| 1
reach
"MGI.A and MGI.B, which were more abundant in subsurface and mesopelagic layers, were mainly contributed by OTU6 and OTU2, respectively."
29109713
OTUB2 affects MGI.A
| 1
OTUB2 activates MGI.A. 1 / 1
| 1
reach
"MGI.A and MGI.B, which were more abundant in subsurface and mesopelagic layers, were mainly contributed by OTU6 and OTU2, respectively."
29109713
OTUB2 affects MAP3K7
| 1
OTUB2 inhibits MAP3K7. 1 / 1
| 1
reach
"Furthermore, the DUBs OTUB1 and OTUB2 also negatively regulate TAK1 signaling by removing K63 chains from TRAF6 after viral infection (Figs."
22964110
OTUB2 affects LZTS2
1 |
OTUB2 binds LZTS2. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects KRT80
| 1
OTUB2 binds KRT80. 1 / 1
| 1
sparser
"As we expected, we discovered an interaction between OTUB2 and KRT80."
35110531
OTUB2 affects KRT40
1 |
OTUB2 binds KRT40. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects KRT31
1 |
OTUB2 binds KRT31. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects KDM1A
| 1
OTUB2 increases the amount of KDM1A. 1 / 1
| 1
reach
"Notably, we demonstrated that OTUB2 increased lysine-specific histone demethylase 1A (KDM1A) expression through deubiquitination."
34646768
OTUB2 affects Interferon
| 1
OTUB2 inhibits Interferon. 1 / 1
| 1
reach
"These findings suggest that OTUB1 and OTUB2 negatively regulate virus triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and -6."
19996094
OTUB2 affects INS
| 1
OTUB2 activates INS. 1 / 1
| 1
reach
"OTUB2 knockdown increased caspase-3/7 activity in MIN6 cells and primary human islets and inhibited insulin secretion and increased nuclear factor-kappaB (NF-kappaB) activity both under basal conditions and following cytokine treatment."
23515685
OTUB2 affects Histone
| 1
OTUB2 leads to the deubiquitination of Histone. 1 / 1
| 1
reach
"However, OTUB2 does not suppress histone ubiquitination induced by RNF168 overexpression [XREF_BIBR]."
26983989
OTUB2 affects Hedgehog
| 1
OTUB2 activates Hedgehog. 1 / 1
| 1
eidos
"( C ) Hedgehog signaling : OTUB2 enhances Hh signaling through deubiquitinating Gli2 ."
36340031
OTUB2 affects HR
| 1
OTUB2 activates HR. 1 / 1
| 1
reach
"OTUB1 binds Ubc13 (UBE2N) to inhibit K63-linked-ubiquitination of chromatin in DSB repair, whereas its ohnolog, OTUB2, shows much lower affinity for Ubc13 and instead promotes HR by interacting with another novel ohnolog, L3MBTL1."
28177072
OTUB2 affects HK2
| 1
Modified OTUB2 increases the amount of HK2. 1 / 1
| 1
reach
"Overexpression of OTUB2 upregulated the expression of PFKL and PGK1 in H292 cells and upregulated the expression of HK2, PFKL, PGK1, and PGAM1 in XL-2 cells."
30662561
OTUB2 affects GTF2I
1 |
OTUB2 binds GTF2I. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUB2 affects GPBP1
1 |
OTUB2 binds GPBP1. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUB2 affects ESR2
| 1
OTUB2 activates ESR2. 1 / 1
| 1
reach
"Clearly, the RTP values of compounds 2a and 2c are far greater for the ERbeta mediated response (OTUB2 activation in ERalpha + ERbeta cells) than the ERalpha mediated response (PR activation in ERalpha only cells)."
25559213
OTUB2 affects ESR1
| 1
OTUB2 activates ESR1. 1 / 1
| 1
reach
"Clearly, the RTP values of compounds 2a and 2c are far greater for the ERbeta mediated response (OTUB2 activation in ERalpha + ERbeta cells) than the ERalpha mediated response (PR activation in ERalpha only cells)."
25559213
OTUB2 affects ECAR
| 1
OTUB2 activates ECAR. 1 / 1
| 1
reach
"As expected, we verified that OTUB2 overexpression increased ECAR, glucose uptake, and lactate production, while knockdown of OTUB2 impaired the aerobic glycolytic phenotype in different NSCLC cell lines."
30662561
OTUB2 affects Disease
| 1
OTUB2 activates Disease. 1 / 1
| 1
reach
"OTUB2 is likely to cause cancer and other malignant diseases while maintaining normal human development and physiological function."
35309903
OTUB2 affects DNA Damage
| 1
OTUB2 inhibits DNA Damage. 1 / 1
| 1
reach
"OTUB2 was recently reported to suppress DNA damage responses through suppression of deubiquitylation of ubiquitylated proteins with RNF8 XREF_BIBR."
27507734
OTUB2 affects DDX58
| 1
OTUB2 inhibits DDX58. 1 / 1
| 1
sparser
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63-linked polyubiquitin chains. [172] Because various components are involved in virusinduced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG-I-, MDA5-, and MAVS-mediated but not TBK1-and IRF3-mediated signaling."
33511009
reach
"Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis."
36858343
OTUB2 affects Caspase_3_7
| 1
OTUB2 inhibits Caspase_3_7. 1 / 1
| 1
reach
"OTUB2 knockdown increased caspase-3/7 activity in MIN6 cells and primary human islets and inhibited insulin secretion and increased nuclear factor-kappaB (NF-kappaB) activity both under basal conditions and following cytokine treatment."
23515685
OTUB2 affects CTNNB1-ZEB1
| 1
OTUB2 activates CTNNB1-ZEB1. 1 / 1
| 1
reach
"Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis."
36858343
OTUB2 affects CRC
| 1
OTUB2 activates CRC. 1 / 1
| 1
reach
"Here we demonstrate that OTUB2, an OTU deubiquitinase, is upregulated in colorectal cancer (CRC) and exacerbates the progression of CRC through modulating the aerobic glycolysis."
34671086
OTUB2 affects CPSF6
1 |
CPSF6 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects CPLX3
1 |
OTUB2 binds CPLX3. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUB2 affects CALML3
| 1
OTUB2 activates CALML3. 1 / 1
| 1
reach
"OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis."
36288705
OTUB2 affects BCL2L11
| 1
OTUB2 activates BCL2L11. 1 / 1
| 1
reach
"Along the salinity gradient, OTU1 abundance increased with decreasing water temperatures and increasing rainfalls, and it showed a maximum in January; OTU2 increased with increasing BOD 5 and it showed the highest abundances in the period August-October, and OTU 3194 increased at decreasing salinities."
35456840
OTUB2 affects ATXN3
1 |
OTUB2 binds ATXN3. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUB2 affects ATP
| 1
OTUB2 activates ATP. 1 / 1
| 1
reach
"Moreover, OTUB2 depletion reduces glucose consumption, lactate production, and cellular ATP production."
34671086
OTUB2 affects ARRDC3
1 |
OTUB2 binds ARRDC3. 1 / 1
1 |
biogrid
No evidence text available
25416956
OTUB2 affects APP
1 |
OTUB2 binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
OTUB2 affects AKT
| 1
OTUB2 inhibits AKT. 1 / 1
| 1
reach
"In addition, OTUB2 inhibition deactivated the AKT/mTOR signaling in CC cells."
37334762
OTUB2 affects ABCE1
| 1
OTUB2 binds ABCE1. 1 / 1
| 1
sparser
"The interaction of Rli1 with Otu2 was further confirmed by immunoblot analysis using strains endogenously expressing GFP-tagged Rli1 and Otu2-3×Flag ( xref C)."
33665564
NMRAL1 affects OTUB2
1 |
OTUB2 binds NMRAL1. 1 / 1
1 |
biogrid
No evidence text available
24763515
N-nitrosodimethylamine decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25380136
MID2 affects OTUB2
1 |
OTUB2 binds MID2. 1 / 1
1 |
biogrid
No evidence text available
25416956
MID1 affects OTUB2
1 |
OTUB2 binds MID1. 1 / 1
1 |
biogrid
No evidence text available
25416956
MAVS affects OTUB2
1 |
OTUB2 binds MAVS. 1 / 1
1 |
biogrid
No evidence text available
19996094
LZTS2 affects OTUB2
1 |
OTUB2 binds LZTS2. 1 / 1
1 |
biogrid
No evidence text available
25416956
L-methionine affects OTUB2
1 |
L-methionine methylates OTUB2. 1 / 1
1 |
ctd
No evidence text available
20938992
KRT80 affects OTUB2
| 1
OTUB2 binds KRT80. 1 / 1
| 1
sparser
"As we expected, we discovered an interaction between OTUB2 and KRT80."
35110531
KRT40 affects OTUB2
1 |
OTUB2 binds KRT40. 1 / 1
1 |
biogrid
No evidence text available
25416956
KRT31 affects OTUB2
1 |
OTUB2 binds KRT31. 1 / 1
1 |
biogrid
No evidence text available
25416956
JUN affects OTUB2
1 |
JUN decreases the amount of OTUB2. 1 / 1
1 |
biopax:msigdb
No evidence text available
GTF2I affects OTUB2
1 |
OTUB2 binds GTF2I. 1 / 1
1 |
biogrid
No evidence text available
19615732
GPBP1 affects OTUB2
1 |
OTUB2 binds GPBP1. 1 / 1
1 |
biogrid
No evidence text available
28514442
ETS2 affects OTUB2
1 |
ETS2 decreases the amount of OTUB2. 1 / 1
1 |
biopax:msigdb
No evidence text available
Delta(9)-tetrahydrocannabinol increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
16616335
Cuprizone affects OTUB2
1 |
Cuprizone decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
26577399
CPSF6 affects OTUB2
1 |
CPSF6 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
25416956
CPLX3 affects OTUB2
1 |
OTUB2 binds CPLX3. 1 / 1
1 |
biogrid
No evidence text available
28514442
ATXN3 affects OTUB2
1 |
OTUB2 binds ATXN3. 1 / 1
1 |
biogrid
No evidence text available
19615732
ARRDC3 affects OTUB2
1 |
OTUB2 binds ARRDC3. 1 / 1
1 |
biogrid
No evidence text available
25416956
APP affects OTUB2
1 |
OTUB2 binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
ABCE1 affects OTUB2
| 1
OTUB2 binds ABCE1. 1 / 1
| 1
sparser
"The interaction of Rli1 with Otu2 was further confirmed by immunoblot analysis using strains endogenously expressing GFP-tagged Rli1 and Otu2-3×Flag ( xref C)."
33665564
3-isobutyl-1-methyl-7H-xanthine increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
28628672
2-hydroxypropanoic acid decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
30851411
17beta-estradiol affects OTUB2
1 |
17beta-estradiol increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
30165855
17alpha-ethynylestradiol increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
17942748
1-naphthyl isothiocyanate decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25380136
4,4'-diaminodiphenylmethane decreases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25380136
3,3',5,5'-tetrabromobisphenol A increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
25172293
2,3',4,4',5-pentachlorobiphenyl increases the amount of OTUB2. 1 / 1
1 |
ctd
No evidence text available
31388691