IndraLab

Statements

TP53 affects MYSM1
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TP53 binds MYSM1.
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TP53 binds MYSM1. 10 / 11
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"MYSM1 therefore interacts with p53, either directly or more likely as part of a larger protein complex."
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"At the Cdkn1a/ p21 locus, increased H3K27ac and H3K4me3 levels were also observed, but without increased p53 binding ( xref ), which indicates that MYSM1 can have an impact on H3K27ac levels independently of effects on p53 recruitment."
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"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 and PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a and p21."
26768662
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"We thus generated double-knockout mice to assess a potential genetic interaction between Mysm1 and p53 in hematopoiesis."
25710881
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"We thus generated double-knockout mice to assess a potential genetic interaction between Mysm1 and p53 in hematopoiesis."
25710881
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"Interaction between MYSM1 and p53 proteins was demonstrated in hematopoietic cell lines through co-immunoprecipitation (co-IP) [ xref ], and MYSM1 binding to the promoters of several p53 stress response genes was also reported, suggesting possible mechanisms for p53 regulation by MYSM1."
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"Given the recruitment of MYSM1 to genomic p53 binding sites, we tested for interaction between MYSM1 and p53 proteins."
26768662
sparser
"MYSM1 therefore interacts with p53, either directly or more likely as part of a larger protein complex."
26768662
sparser
"Given the recruitment of MYSM1 to genomic p53-binding sites, we tested for interaction between MYSM1 and p53 proteins."
26768662
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3/PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a/p21."
26768662
TP53 binds MYSM1 and ARF. 1 / 1
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"In line with a previous report on Mysm1-binding to thep19 ARF -promoter in thymocytes [ xref ], an upstream regulator of TS p53, in Mysm1 −/− epidermal cells as well, mRNA expression ofp19 ARF was moderately increased along with increases in p53 levels and in apoptosis."
29495602
TP53 binds CDKN1A, BBC3, and MYSM1. 1 / 1
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"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 /PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a /p21."
26768662
TP53 activates MYSM1.
| 12
TP53 activates MYSM1. 10 / 11
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"Our study also provides important insights into the unique effects of p53 stress responses in HSCs, where p53 activation in Mysm1 deficiency does not result in apoptosis, but promotes loss of quiescence."
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"To our knowledge, the role of p53 activation in Mysm1 deficient NK cell dysfunction has not been addressed [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"The suggested triggers for p53 activation in Mysm1 -/- include the putative roles of MYSM1 in the maintenance of p19ARF expression within the thymus [XREF_BIBR], and IRF2 and IRF8 expression in bone marrow progenitor cells [XREF_BIBR]."
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"XREF_BIBR, XREF_BIBR Importantly, Cdkn2a expression was undetectable in Mysm1 deficient HSPCs or MPPs, demonstrating the distinct mechanism of p53 activation in Mysm1 -/- HSPCs, as compared with thymocytes."
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"As increased p19 ARF / p53 activation in developing Mysm1 deficient mice could be a consequence of checkpoint activation, a default pathway, or be induced as a result of a lack of 2A-DUB/Mysm1 action in regulatory complexes involved in repression of the Cdkn2a (Ink4 and Arf) locus, we next set out to explore Mysm1 binding to fragments of the p19 ARF promoter in activated thymocytes."
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"As induction of Cdkn2a and p19 ARF was previously implicated in p53 activation in Mysm1 -/- thymocytes, 39 we conclude that the mechanisms of p53 activation in Mysm1 deficient HSPCs are distinct and p19 ARF -independent."
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"However, the mechanisms triggering p53 activation in Mysm1 -/- HSPCs, and the pathways downstream of p53 driving different aspects of the Mysm1 -/- phenotype remain unknown."
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"Using double-knockout mouse models, we establish that PUMA, but not p21, is an important mediator of p53 driven Mysm1 -/- hematopoietic dysfunction."
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"P53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency."
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"In summary, our results demonstrate novel roles for Mysm1 in osteoblast differentiation and osteoclast formation, resulting in osteopenia in Mysm1 deficient mice that could be abrogated by the loss of p53 from increased osteogenic differentiation of Mysm1 -/- p53 -/- MSCs.-Haffner-Luntzer, M., Kovtun, A., Fischer, V., Prystaz, K., Hainzl, A., Kroeger, C. M., Krikki, I., Brinker, T. J., Ignatius, A., Gatzka, M. Loss of p53 compensates osteopenia in murine Mysm1 deficiency."
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Modified TP53 activates MYSM1. 1 / 1
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"36 Here, we observed enhanced p53 levels in Poly (I : C)-treated mice that paralleled increases in Mysm1 expression, and that there was enhanced p53 transcription in Mysm1 -/- HSCs."
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MYSM1 affects TP53
| 1 15 9
MYSM1 binds TP53.
| 4 9
TP53 binds MYSM1. 10 / 11
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"MYSM1 therefore interacts with p53, either directly or more likely as part of a larger protein complex."
26768662
sparser
"At the Cdkn1a/ p21 locus, increased H3K27ac and H3K4me3 levels were also observed, but without increased p53 binding ( xref ), which indicates that MYSM1 can have an impact on H3K27ac levels independently of effects on p53 recruitment."
26768662
reach
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 and PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a and p21."
26768662
sparser
"We thus generated double-knockout mice to assess a potential genetic interaction between Mysm1 and p53 in hematopoiesis."
25710881
reach
"We thus generated double-knockout mice to assess a potential genetic interaction between Mysm1 and p53 in hematopoiesis."
25710881
sparser
"Interaction between MYSM1 and p53 proteins was demonstrated in hematopoietic cell lines through co-immunoprecipitation (co-IP) [ xref ], and MYSM1 binding to the promoters of several p53 stress response genes was also reported, suggesting possible mechanisms for p53 regulation by MYSM1."
32344625
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"Given the recruitment of MYSM1 to genomic p53 binding sites, we tested for interaction between MYSM1 and p53 proteins."
26768662
sparser
"MYSM1 therefore interacts with p53, either directly or more likely as part of a larger protein complex."
26768662
sparser
"Given the recruitment of MYSM1 to genomic p53-binding sites, we tested for interaction between MYSM1 and p53 proteins."
26768662
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3/PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a/p21."
26768662
TP53 binds MYSM1 and ARF. 1 / 1
| 1
sparser
"In line with a previous report on Mysm1-binding to thep19 ARF -promoter in thymocytes [ xref ], an upstream regulator of TS p53, in Mysm1 −/− epidermal cells as well, mRNA expression ofp19 ARF was moderately increased along with increases in p53 levels and in apoptosis."
29495602
TP53 binds CDKN1A, BBC3, and MYSM1. 1 / 1
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sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 /PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a /p21."
26768662
MYSM1 inhibits TP53.
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MYSM1 inhibits TP53. 4 / 4
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"53 Our work shows that MYSM1 represses p53 stress response genes by antagonizing other histone modifications (H3K27ac and H3K4me3)."
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"Mysm1-deficiency is known to result in p53 activation in hematopoietic cells [XREF_BIBR, XREF_BIBR, XREF_BIBR], indicating that MYSM1 normally represses p53 activation, and suggesting it as a possible target for therapeutic p53 activation in hematological malignancies that retain wild type p53 function."
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"As Mysm1 generally functions as a transcription activator, it is rational to postulate that Mysm1 suppresses p53 or p19 ARF likely by activating expression of transcription repressors."
27277682
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"Mysm1-deficiency is known to result in p53-activation in hematopoietic cells [ 19,44,45 ] , indicating that MYSM1 normally represses p53 activation , and suggesting it as a possible target for therapeutic p53-activation in hematological malignancies that retain wild type p53 function ."
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MYSM1 increases the amount of TP53.
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MYSM1 increases the amount of TP53. 3 / 3
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"To investigate the underlying mechanisms, we first confirmed that Mysm1 -/- mice had enhanced p53 levels in the Lin - HSCs and LSKs as determined by ICS assays (XREF_FIG)."
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"Nijnik et al. 15 demonstrated that Mysm1 -/- mice have enhanced levels of p53, which is a central regulator of cellular stress responses."
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"Further studies revealed that Mysm1 suppressed p53-target gene Bbc3 and PUMA for HSC maintenance 49 and Mysm1 -/- enhanced p53 levels by upregulation of p19 ARF."
27277682
MYSM1 activates TP53.
| 3
MYSM1 activates TP53. 3 / 3
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"Overall, we demonstrate that the loss of MYSM1 in mouse B cell lymphoma represses the induction of ribosomal protein genes, reduces cellular protein synthesis rate, promotes p53 activation and potently inhibits cMYC oncogenic functions.To compare the location of the genomic binding sites of MYSM1 and cMYC, we consolidated the ChIP‐Seq datasets for cMYC and its dimerization partner MAX from multipotent haematopoietic progenitor cells HPC7 12 , 13 with the MYSM1 ChIP‐Seq acquired in our recent work in a B cell progenitor cell line Ba/F3."
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"We recently demonstrated that all developmental and hematopoietic phenotypes of Mysm1 deficiency are p53 mediated and rescued in the Mysm1 -/- p53 -/- mouse model."
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"Furthermore, we identify potential mediators of p53 dependent but PUMA independent Mysm1 -/- hematopoietic deficiency phenotypes."
26768662
MYSM1 decreases the amount of TP53.
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MYSM1 decreases the amount of TP53. 2 / 2
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"Our work demonstrates that MYSM1 represses p53 stress response gene expression by localizing to p53 binding sites within Bbc3 and PUMA and Cdkn1a and p21 promoters and antagonizing local histone modification (H3K27ac and H3K4me3) and p53 recruitment (XREF_FIG)."
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"IRF2 and IRF8 reduction in Mysm1 -/- HSCs enhances p53 levels."
27277682
MYSM1 affects KAT2B
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MYSM1 binds KAT2B. 10 / 14
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"2A-DUB interacts with p/CAF in a coregulatory protein complex, with its deubiquitinase activity modulated by the status of acetylation of nucleosomal histones."
17707232
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"Interestingly, 2A-DUB associates with PCAF, a histone acetyltransferase subunit of the hSAGA complex."
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"Correlating with the recruitment of 2A-DUB and p/CAF, a clear decrease of uH2A levels and a coincidently increased level of acetylated H3 (Ac-H3) were observed upon DHT treatment in LNCaP cells, sugge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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No evidence text available
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"2A-DUB interacts with PCAF and is required for full activation of androgen receptor-dependent genes (Zhu et al., xref )."
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"Displacement of linker histones, which is facilitated by their phosphorylation, is generally linked to gene activation but has also been linked to repression in a few instances, coincident with the co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"2A-DUB interacts with PCAF and is required for full activation of androgen receptor dependent genes."
22649782
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"Unexpectedly, specific interactions between p/CAF and 2A-DUB, as components of a protein complex, seem to coordinate histone ubiquitination and acetylation."
17707232
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"Coimmunoprecipitation assays further confirmed a specific interaction of 2A-DUB with p/CAF, as well as interactions with R NA- b inding m otif protein 10 (RBM10) and t hyroid hormone r eceptor ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
MYSM1 affects AR
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MYSM1 binds AR.
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MYSM1 binds AR. 8 / 8
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"In this work we observed MYSM1-AR interactions which may be also responsible for the role of MYSM1 in androgen-responsive gene transcription."
31761786
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"Given the repression of AR transactivation by interaction of LCOR with AR [ xref ], we then concentrated on the interaction between MYSM1 and AR to dissect the functional significance of MYSM1 in AR signaling."
31761786
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"To verify the potential interaction between MYSM1 and AR, we carried out protein co-immunoprecipitation (Co-IP) assays with validated antibodies against MYSM1 and AR in C4-2 cells with or without siMYSM1 treatment."
31761786
sparser
"In summary, these findings demonstrate that MYSM1 can bind to AR and suppress the activation of Akt pathway in CRPC by downregulating phosphorylation levels of Akt, c-Raf and GSK-3β."
31761786
sparser
"MYSM1 was able to bind to androgen receptor instead of increasing its expression and knockdown of MYSM1 resulted in activation of Akt/c-Raf/GSK-3β signaling."
31761786
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"MYSM1 interacts with AR and inhibits activation of Akt/c-Raf/GSK-3β signaling in prostate cancer."
31761786
sparser
"Further mechanistic investigation indicated that MYSM1-AR interaction and Akt/c-Raf/GSK-3β pathway may underlie the role of MYSM1 in CRPC progression."
31761786
sparser
"As 2A-DUB may interact with AR via its SWIRM domain ( Metzger et al., 2005 ), recruitment of the complex might be AR dependent."
17707232
MYSM1 binds AR and SWIRM domain. 1 / 1
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"As 2A-DUB may interact with AR via its SWIRM domain (Metzger et al., 2005), recruitment of the complex might be AR dependent."
17707232
MYSM1 increases the amount of AR.
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MYSM1 increases the amount of AR. 4 / 4
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"2A-DUB, a JAMM family DUB, was found to deubiquitinate H2A and positively regulate transcription of androgen receptor regulated genes in concert with the histone acetylase p and CAF complex [XREF_BIBR]."
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"MYSM-1 can activate transcription of AR target genes via its involvement with p300 affecting histone acetylation and deubiquitination and binding of H1 to the nucleosome [XREF_BIBR]."
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"Recent work has shown that 2A-DUB acts as a co-activator of the androgen receptor (AR), modulating full activation of AR dependent gene expression through deubiquitination of H2A."
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"27 In prostate cancer cells, Mysm1 activates transcription of androgen receptor regulated genes as part of a co and regulatory complex with histone acetyltransferase p300 and CBP associated factor by coordinating histone acetylation and deubiquitination, and by destabilizing the association of linker histone H1 with nucleosomes."
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MYSM1 affects MYC
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MYSM1 binds MYC.
| 5 2
MYSM1 binds MYC. 7 / 7
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"Here, we show that MYSM1 and c-Myc bind to the same region (approximately 1200–1000 nt upstream) of the promoter of miR-150 in B1a cells from WT mice but c-Myc cannot bind to the promoter in MYSM1 −/− mice."
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"10 To further validate the overlap in the genomic binding sites of MYSM1 and cMYC in Ba/F3 cells, the binding of cMYC at the MYSM1‐binding sites of select genes encoding RPs and translation factors was tested and confirmed with ChIP‐qPCR (Figure 1E, Supporting Information S1)."
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"The binding of MYSM1 and cMYC at the shared sites was also confirmed in cells derived from EuMyc mouse B cell lymphoma, 14 , 15 specifically for the Rpl7 and Eef1g gene promoters (data not shown)."
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"Overall, we demonstrate shared DNA binding of cMYC and MYSM1 at the promoters of genes encoding ribosomal proteins and translation factors."
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"Meanwhile, co-Immunoprecipitation (co-IP) was performed to detect the interaction between MYSM1 and c-Myc and results showed that MYSM1 protein co-immunoprecipitated with c-Myc in murine RAW264.7 cells."
27590507
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"Meanwhile, co-Immunoprecipitation (co-IP) was performed to detect the interaction between MYSM1 and c-Myc and results showed that MYSM1 protein co-immunoprecipitated with c-Myc in murine RAW264.7 cells (Figure xref )."
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"Overall, this suggested a possible cooperation between cMYC and MYSM1 in the transcriptional regulation of genes encoding ribosomal proteins and translation factors.We have previously validated MYSM1 binding to the promoters of RP genes in Ba/F3 cells by ChIP‐qPCR, and also demonstrated a reduction in RP‐gene expression in Mysm1‐shRNA knockdown Ba/F3 cells and in Mysm1‐deficient primary haematopoietic stem and progenitor cells."
34114734
MYSM1 activates MYC.
| 4
MYSM1 activates MYC. 3 / 3
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"This indicates that the loss of MYSM1 can inhibit the oncogenic activity of cMYC and delay the onset of fatal lymphoma.To further establish the protective effect of MYSM1‐loss on lymphoma disease progression, we employed an adoptive lymphoma cell transfer model."
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"This firmly establishes that loss of MYSM1 inhibits the oncogenic activity of cMYC, and protects against B cell lymphoma onset and progression in mouse models.To understand the mechanisms underlying the protective activity of MYSM1‐loss in B cell lymphoma, EuMyc tumours were harvested from Mysm1 and control mice, and lymphoma cells isolated by cell‐sorting as live B220 cells, for ex vivo analyses with qRT‐PCR and intracellular flow cytometry."
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"Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma."
34114734
MYSM1 activates MYC. 1 / 1
| 1
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"Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma."
34114734
MYSM1 activates transcription, DNA-templated. 8 / 8
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"Further, we tested the possibility that MYSM1 may directly activate the transcription of Pax5 in mature B cells as well."
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"MYSM1 deubiquitinates monoubiquitinated histone H2A and directs the recruitment of transcription factors to the promoter of target genes, including EBF1 and PU.1."
27590507
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"The histone H2A deubiquitinase 2A-DUB or Mysm1/Kiaa1915 (Myb-like SWIRM and MPN domain containing1) is a nuclear protein of 828 amino acids containing a SWIRM domain, a SANT (SWI-SNF, ADA N-CoR, TFIIIB) domain with DNA-binding activity and a JAMN/MPN domain with intrinsic metalloprotease-like activity. xref In prostate cancer cells, Mysm1 activates transcription of androgen receptor-regulated genes as part of a co-regulatory complex with histone acetyltransferase p300/CBP-associated factor by coordinating histone acetylation and deubiquitination, and by destabilizing the association of linker histone H1 with nucleosomes. xref More recently, analysis of Mysm1 knockout mice revealed additional functions of the H2A-DUB in regulation of hematopoietic development as Mysm1 deficiency resulted in – among other abnormalities – severe depletion of B cells and T cells, anemia, and thrombocytosis. xref , xref Comparable with the pathophysiology of mice lacking PRC1 component Bmi1, xref postnatal lymphopenia in Mysm1-deficient mice correlated with a depletion of HSC likely resulting from activation of the DDR and uncontrolled production of reactive oxygen species (ROS). xref In murine skin, Mysm1 deficiency was associated with atrophy (present article and own unpublished observations) and malformation of the tail. xref "
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"MYSM1 stimulates transcription of miR-150 in B1a cells with c-Myc."
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"MYSM1 and USP16 activate transcription."
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"An interesting area of future studies is to systemically identify MYSM1 partners and investigate the underlying molecular mechanisms for the selective gene targeting and transcription regulation by MYSM1."
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"Mechanistic studies revealed that MYSM1 activates Pax5 transcription by coordinating histone modifications and directing the recruitment of the transcription activators such as PU.1 to the Pax5 locus in B cells."
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"MYSM1 reverses the transcription repression of genes that are involved in hematopoietic stem cell homeostasis, hematopoiesis, and lymphocyte differentiation (94)."
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"MYSM1 reverses the transcription repression of genes that are involved in hematopoietic stem cell homeostasis , hematopoiesis , and lymphocyte differentiation ( 94 ) ."
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AR affects MYSM1
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MYSM1 binds AR. 8 / 8
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sparser
"In this work we observed MYSM1-AR interactions which may be also responsible for the role of MYSM1 in androgen-responsive gene transcription."
31761786
sparser
"Given the repression of AR transactivation by interaction of LCOR with AR [ xref ], we then concentrated on the interaction between MYSM1 and AR to dissect the functional significance of MYSM1 in AR signaling."
31761786
sparser
"To verify the potential interaction between MYSM1 and AR, we carried out protein co-immunoprecipitation (Co-IP) assays with validated antibodies against MYSM1 and AR in C4-2 cells with or without siMYSM1 treatment."
31761786
sparser
"In summary, these findings demonstrate that MYSM1 can bind to AR and suppress the activation of Akt pathway in CRPC by downregulating phosphorylation levels of Akt, c-Raf and GSK-3β."
31761786
sparser
"MYSM1 was able to bind to androgen receptor instead of increasing its expression and knockdown of MYSM1 resulted in activation of Akt/c-Raf/GSK-3β signaling."
31761786
sparser
"MYSM1 interacts with AR and inhibits activation of Akt/c-Raf/GSK-3β signaling in prostate cancer."
31761786
sparser
"Further mechanistic investigation indicated that MYSM1-AR interaction and Akt/c-Raf/GSK-3β pathway may underlie the role of MYSM1 in CRPC progression."
31761786
sparser
"As 2A-DUB may interact with AR via its SWIRM domain ( Metzger et al., 2005 ), recruitment of the complex might be AR dependent."
17707232
MYSM1 binds AR and SWIRM domain. 1 / 1
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"As 2A-DUB may interact with AR via its SWIRM domain (Metzger et al., 2005), recruitment of the complex might be AR dependent."
17707232
MYSM1 is modified
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MYSM1 is phosphorylated on S218. 2 / 2
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hprd
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hprd
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MYSM1 is phosphorylated on S234. 2 / 2
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hprd
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hprd
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MYSM1 is phosphorylated on S267. 2 / 2
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hprd
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hprd
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MYSM1 is phosphorylated on T226. 1 / 1
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hprd
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MYSM1 is phosphorylated on S110. 1 / 1
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hprd
No evidence text available
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MYSM1 activates cell population proliferation. 6 / 6
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"Survival and proliferation of melanoma cells is supported by MYSM1."
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"These findings indicated that MYSM1 promotes cell proliferation and colony formation and attenuates SA-beta-Gal activation to repress senescence ."
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"Mysm1 -/- mice had enhanced HSC proliferation that led to a large dysfunctional LSK population."
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"Knockdown of MYSM1 promoted cell proliferation and suppressed senescence of CRPC cells under condition of androgen ablation."
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"Meanwhile, MYSM1 knockout reduces the proliferation of osteoclast progenitor and the osteoclast resorption activity [130]."
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"In a separate study, Mysm1 -/- macrophages were confirmed to have elevated production of pro inflammatory cytokines in response to stimulation, as well as increased proliferation, increased apoptosis, and enhanced capacity to control melanoma tumor growth in vivo in mouse models [XREF_BIBR]."
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MYSM1 inhibits cell population proliferation. 2 / 2
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"It was found that MYSM-1 could suppress the proliferation, migration, and invasion of renal carcinoma cells."
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"In conclusion, we reveal a novel pathway involving MYSM1, miR-150, and FLT3, which inhibits B1a cell proliferation and a defect in this pathway may contribute to the pathogenesis of SLE."
27590507
MYSM1 inhibits cell differentiation.
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"We demonstrated that MYSM1 intrinsically represses plasma cell differentiation and antibody production."
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"We revealed that MYSM1 intrinsically represses plasma cell differentiation and antibody production."
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"Mechanistic studies revealed that MYSM1 intrinsically represses plasma cell differentiation and antibody production by activating the transcription of Pax5, the repressors of plasma cell differentiation, in mature B cells."
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"Taken together, these data demonstrate that MYSM1 is an intrinsic repressor of plasma cell differentiation."
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"Thus, these data demonstrate that MYSM1 represses plasma cell differentiation, as well as Ig production by plasma cells."
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"MYSM1 negatively regulates differentiation of human B cells to plasma cells."
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"MYSM1 intrinsically represses plasma cell differentiation."
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MYSM1 activates cell differentiation.
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MYSM1 activates cell differentiation. 1 / 1
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"XREF_FIG shows that forced expression of MYSM1, but not control, rescued the enhanced plasma cell differentiation of Mysm1 -/- B cells."
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MYSM1 affects Flag
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MYSM1 binds Flag. 8 / 8
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"In addition, as proof of principle of the co-IP approach, MYSM1 interaction with ubiquitinated histone H2A (H2Aub), a known substrate of the H2A deubiquitinase, was detectable in the anti-Flag pull-down from MYSM1-Flag transfectants, as expected ( xref C, lower panel)."
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"Identification of MYSM1 Interaction Partners by Co-Immunoprecipitation-coupled Mass Spectrometry in MYSM1-Flag 293T Cells."
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"Subsequently, the IP eluates from MYSM1-Flag and GFP-Flag transfected 293T cells, processed according to the workflow in xref A, were subjected to SCX-HPLC MS/MS mass spectrometry in order to identify novel MYSM1 interactions in DDR."
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"In differential display analyses, relevant DNA damage-dependent MYSM1 candidate interaction partners were defined as proteins differentially enriched by at least 4-fold (log2(4) = 2) in MYSM1-Flag eluates upon etoposide vs. DMSO treatment by anti-Flag vs. IgG IP, but not present in GFP-Flag eluates ( xref A)."
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"Specific potential MYSM1 interactors were classified as proteins with at least > 16-fold (log2(16) = 4) differential enrichment in MYSM1-Flag anti-Flag vs. IgG eluates, but not in the GFP-Flag eluates."
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"At first, robust expression of GFP-Flag and MYSM1-Flag fusion proteins, as well as DNA damage induction by etoposide, were confirmed in comparison to endogenous MYSM1 levels in parental and DMSO-treated 293 T cells by Western blot ( xref B) and by IF analyses (not shown)."
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"As an internal quality control, successful and specific co-IP of fusion proteins by anti-Flag compared with control IgG were affirmed in lysates from MYSM1-Flag transfected 293T cells vs. GFP-Flag controls, respectively, prior to sample analysis by mass spectrometry ( xref C)."
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"To identify new candidate MYSM1 interaction partners and further investigate the molecular function of MYSM1 in DNA damage responses (DDR), we subsequently performed co-immunoprecipitation (co-IP) experiments in 293T cells transiently overexpressing MYSM1-Flag or GFP-Flag upon treatment with etoposide, followed by an SCX-HPLC MS/MS mass spectrometry proteomics approach [ xref , xref ]."
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STING1 affects MYSM1
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STING1 binds MYSM1. 6 / 6
| 6
sparser
"MYSM1 subsequently interacts with STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling ( xref )."
36189363
sparser
"MYSM1 interacts with STING and cleaves the ubiquitination of the STING at Lys63 to inhibit cGAS-STING signaling ( xref ) ( xref )."
36172373
sparser
"In addition, MYSM1 interacts with STING to cleave STING ubiquitination and attenuate the pathway, and MYSM1-deficient mice exhibit tissue damage and high mortality upon virus infection (105)."
34707613
sparser
"MYSM1 interacts with the STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling pathway ( xref )."
33643304
sparser
"MYSM1 interacts with the STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling pathway (116) ."
33643304
sparser
"MYSM1 subsequently interacts with STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling."
33086059
STING1 binds MYSM1 and K63. 1 / 1
| 1
reach
"MYSM1 subsequently interacts with STING and cleaves STING K63 linked ubiquitination to suppress cGAS STING signaling."
33086059
MYSM1 activates Neoplasm Invasiveness.
| 4
reach
"MYSM1 silencing decreases migration and invasion in CRC SW480 cells."
28498834
reach
"Transwell assay and Scratch assay indicated that MYSM1 silencing markedly inhibited cellular invasion and migration in SW480 cells (XREF_FIG)."
28498834
reach
"Scratch assay and Transwell assay showed that MYSM1 silencing decreased migration and invasion abilities of SW480 cells."
28498834
reach
"In the present study, we knocked down MYSM1 expression by transfecting siRNA for MYSM1 to CRC SW480 cells and found that MYSM1 silencing inhibited the migration and invasion of CRC cells, indicating that MYSM1 expression was positively associated with cell migration and invasion, which was identical to the clinicopathologic characteristics."
28498834
MYSM1 inhibits Neoplasm Invasiveness. 3 / 3
| 3
reach
"It was found that MYSM-1 could suppress the proliferation, migration, and invasion of renal carcinoma cells."
26409454
reach
"These data exhibited the correlation between MYSM1 and CRC malignancy involving cell metastasis ability but not cell proliferation ability.However, it has been reported that MYSM1 suppressed cellular migration and invasion in renal carcinoma by inhibiting epithelial-mesenchymal transition [XREF_BIBR]."
28498834
reach
"MYSM-1 suppresses migration and invasion in renal carcinoma through inhibiting epithelial-mesenchymal transition."
26409454
MYC affects MYSM1
| 5 2
MYSM1 binds MYC. 7 / 7
| 5 2
sparser
"Here, we show that MYSM1 and c-Myc bind to the same region (approximately 1200–1000 nt upstream) of the promoter of miR-150 in B1a cells from WT mice but c-Myc cannot bind to the promoter in MYSM1 −/− mice."
27590507
reach
"10 To further validate the overlap in the genomic binding sites of MYSM1 and cMYC in Ba/F3 cells, the binding of cMYC at the MYSM1‐binding sites of select genes encoding RPs and translation factors was tested and confirmed with ChIP‐qPCR (Figure 1E, Supporting Information S1)."
34114734
reach
"The binding of MYSM1 and cMYC at the shared sites was also confirmed in cells derived from EuMyc mouse B cell lymphoma, 14 , 15 specifically for the Rpl7 and Eef1g gene promoters (data not shown)."
34114734
reach
"Overall, we demonstrate shared DNA binding of cMYC and MYSM1 at the promoters of genes encoding ribosomal proteins and translation factors."
34114734
reach
"Meanwhile, co-Immunoprecipitation (co-IP) was performed to detect the interaction between MYSM1 and c-Myc and results showed that MYSM1 protein co-immunoprecipitated with c-Myc in murine RAW264.7 cells."
27590507
sparser
"Meanwhile, co-Immunoprecipitation (co-IP) was performed to detect the interaction between MYSM1 and c-Myc and results showed that MYSM1 protein co-immunoprecipitated with c-Myc in murine RAW264.7 cells (Figure xref )."
27590507
reach
"Overall, this suggested a possible cooperation between cMYC and MYSM1 in the transcriptional regulation of genes encoding ribosomal proteins and translation factors.We have previously validated MYSM1 binding to the promoters of RP genes in Ba/F3 cells by ChIP‐qPCR, and also demonstrated a reduction in RP‐gene expression in Mysm1‐shRNA knockdown Ba/F3 cells and in Mysm1‐deficient primary haematopoietic stem and progenitor cells."
34114734
SMARCA2 affects MYSM1
| 1 5
SMARCA2 binds SMARCA4 and MYSM1. 4 / 4
| 4
sparser
"An interaction of MYSM1 with the BRM and BRG1 components of the SWI/SNF chromatin remodeling complex was also suggested to have a role in the regulation of Ebf1 locus expression [ xref ]."
32344625
sparser
"To confirm the interaction of MYSM1 with BRM or BRG-1, we performed co-immunoprecipitation assays. xref show that MYSM1 was co-precipitated with endogenous BRM and BRG-1 in 293 cells that were transfected with the Flag-MYSM1 expression vector ( xref )."
22169041
sparser
"To further determine the association of MYSM1 and BRM or BRG-1 at the EBF1 promoter locus, sequential two-step ChIP assays were performed. xref shows the association of both MYSM1 and BRM and/or BRG-1 at the Ebf1 promoter locus of WT BM Lin − progenitors."
22169041
sparser
"Collectively, these data demonstrate that MYSM1 interacts with E2A and BRM and/or BRG-1 and its association is likely involved in MYSM1-mediated Ebf1 transcription in B-cell precursors."
22169041
SMARCA2 binds MYSM1. 2 / 2
| 1 1
reach
"Collectively, these data demonstrate that MYSM1 interacts with E2A and BRM and/or BRG-1 and its association is likely involved in MYSM1 mediated Ebf1 transcription in B-cell precursors."
22169041
sparser
"To further determine the association of MYSM1 and BRM or BRG-1 at the EBF1 promoter locus, sequential two-step ChIP assays were performed. xref shows the association of both MYSM1 and BRM and/or BRG-1 at the Ebf1 promoter locus of WT BM Lin − progenitors."
22169041
MYSM1 affects cellular senescence
| 4 2
MYSM1 inhibits cellular senescence. 6 / 6
| 4 2
eidos
"MYSM1 functionally represses cellular senescence and the aging process by promoting DNA repair ."
33240758
eidos
"MYSM1 represses senescence in aged mice ."
33240758
eidos
"MYSM1 Represses Senescence in Mice As senescence is characterized by the extensive secretion of pro-inflammatory cytokines , [ ."
33240758
reach
"Knockdown of MYSM1 promoted cell proliferation and suppressed senescence of CRPC cells under condition of androgen ablation."
31761786
reach
"MYSM1 functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs."
33240758
eidos
"Whilst evaluating the molecular mechanisms underlying the MYSM1-mediated aging process , we revealed that MYSM1 represses cellular senescence and aging process by facilitation of HR DNA repair ."
33240758
MYSM1 affects SMARCA2
| 1 5
SMARCA2 binds SMARCA4 and MYSM1. 4 / 4
| 4
sparser
"An interaction of MYSM1 with the BRM and BRG1 components of the SWI/SNF chromatin remodeling complex was also suggested to have a role in the regulation of Ebf1 locus expression [ xref ]."
32344625
sparser
"To confirm the interaction of MYSM1 with BRM or BRG-1, we performed co-immunoprecipitation assays. xref show that MYSM1 was co-precipitated with endogenous BRM and BRG-1 in 293 cells that were transfected with the Flag-MYSM1 expression vector ( xref )."
22169041
sparser
"To further determine the association of MYSM1 and BRM or BRG-1 at the EBF1 promoter locus, sequential two-step ChIP assays were performed. xref shows the association of both MYSM1 and BRM and/or BRG-1 at the Ebf1 promoter locus of WT BM Lin − progenitors."
22169041
sparser
"Collectively, these data demonstrate that MYSM1 interacts with E2A and BRM and/or BRG-1 and its association is likely involved in MYSM1-mediated Ebf1 transcription in B-cell precursors."
22169041
SMARCA2 binds MYSM1. 2 / 2
| 1 1
reach
"Collectively, these data demonstrate that MYSM1 interacts with E2A and BRM and/or BRG-1 and its association is likely involved in MYSM1 mediated Ebf1 transcription in B-cell precursors."
22169041
sparser
"To further determine the association of MYSM1 and BRM or BRG-1 at the EBF1 promoter locus, sequential two-step ChIP assays were performed. xref shows the association of both MYSM1 and BRM and/or BRG-1 at the Ebf1 promoter locus of WT BM Lin − progenitors."
22169041
MYSM1 affects PAX5
| 6
MYSM1 activates PAX5.
| 3
MYSM1 activates PAX5. 2 / 2
| 2
reach
"Mechanistic studies demonstrated that MYSM1 is a transcriptional activator of Pax5, the repressors of plasma cell differentiation, by facilitating key transcriptional factor recruitment and coordinating histone modifications at the Pax5 loci."
26348977
reach
"Mechanistic studies revealed that MYSM1 is a transcriptional activator of Pax5, the repressors of plasma cell differentiation, by facilitating key transcriptional factor recruitment and coordinating histone modifications at the Pax5 locus in B cells."
26348977
Modified MYSM1 activates PAX5. 1 / 1
| 1
reach
"MYSM1 expression activated transcription of the Ebf1alpha promoter and modestly activated the Ebf1beta promoter, but only marginally activated the Pax5 promoter and Cd79a promoter."
22169041
MYSM1 increases the amount of PAX5.
| 2
MYSM1 increases the amount of PAX5. 2 / 2
| 2
reach
"Further, we tested the possibility that MYSM1 may directly activate the transcription of Pax5 in mature B cells as well."
26348977
reach
"Mechanistic studies revealed that MYSM1 activates Pax5 transcription by coordinating histone modifications and directing the recruitment of the transcription activators such as PU.1 to the Pax5 locus in B cells."
26348977
MYSM1 decreases the amount of PAX5.
| 1
MYSM1 decreases the amount of PAX5. 1 / 1
| 1
reach
"Altogether, MYSM1 was proposed to inhibit plasma cell differentiation by maintaining Pax5 expression, via histone H2AK119 deubiquitination and recruitment of transcription factor PU.1 to the Pax5 locus [XREF_BIBR] (XREF_FIG)."
32344625
MYSM1 affects H2AC20
3 1 | 2
MYSM1 binds H2AC20.
3 | 2
MYSM1 binds H2AC20. 4 / 4
3 | 1
sparser
"In addition, as proof of principle of the co-IP approach, MYSM1 interaction with ubiquitinated histone H2A (H2Aub), a known substrate of the H2A deubiquitinase, was detectable in the anti-Flag pull-down from MYSM1-Flag transfectants, as expected ( xref C, lower panel)."
32466590
biogrid
No evidence text available
17707232
biogrid
No evidence text available
17707232
biogrid
No evidence text available
21245042
sparser
"In fact, MYSM1 is localized primarily to the nucleus and can directly interact with both H2A and H2B [ xref ]."
32708614
MYSM1 deubiquitinates H2AC20.
1 |
MYSM1 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"Myb-Like, SWIRM, and MPN domains 1 (MYSM1) is a metalloprotease that deubiquitinates the K119-monoubiquitinated form of histone 2A (H2A), a chromatin marker associated with gene transcription silencing."
26220525
ZDHHC2 affects MYSM1
| 5
ZDHHC2 binds MYSM1. 5 / 5
| 5
sparser
"In further support of these findings, incubation of Ub-RIP2 immunoprecipitated from Mysm1 −/− BMDMs with Rec-MYSM1 resulted in diminished K63-, K27-, and M1-linked, but not K48-linked, ubiquitin chains (Supplementary Fig.  xref )."
30405132
sparser
"In contrast, Rec-MYSM1 had no effect on ubiquitin chains attached to NEMO (Supplementary Fig.  xref ), indicating that MYSM1 was selectively cleaving K63, K27, and M1, but not K48 linkages, from RIP2."
30405132
sparser
"Moreover, in vitro, Rec-MYSM1 could remove polyubiquitins from RIP2, but not NEMO (Supplementary Figure  xref )."
30405132
sparser
"Next we purified ubiquitin conjugates from L18-MDP-stimulated Mysm1 − /− BMDMs by TUBE and incubated them with recombinant MYSM1 (Rec-MYSM1) and compared the ubiquitin restriction pattern of Ub-RIP2 with that of AMSH, UCHL3, OTULIN or a combination of these three DUBs (Fig.  xref )."
30405132
sparser
"To gain a complete overview of the ubiquitin linkage specificity of MYSM1, we incubated Rec-MYSM1 with Di-ubiqutins (Ub 2 ) of different linkages."
30405132
RAP1 affects MYSM1
| 5
RAP1 binds MYSM1. 4 / 4
| 4
sparser
"By contrast, Rap1 binding to DNA through a single Myb-like domain results in formation of high stoichiometry complexes that act at DNA ends mostly in a Rif2-independent manner."
31879780
sparser
"Based on the available crystal structures, with such a short DNA duplex it is difficult to rationalize how Rap1 DBD would be able to bind with both Myb-like domains interacting with the DNA."
25637888
sparser
"In fact, a characterization of Rap1 mutant variants shows that Rap1 binding to DNA through both Myb-like domains results in formation of Rap1-DNA complexes that control MRX functions at both DSBs and telomeres primarily through Rif2."
31879780
sparser
"MRX association at DSBs is counteracted by Rif2, which is known to interact with Rap1 that binds telomeric DNA through two tandem Myb-like domains."
31879780
sparser
"For this orientation of the recognition sequence, Rap1 binds with the N-terminal Myb-like region of its DNA-binding domain (DBD) facing the incoming polymerase and with the majority of the Rap1 contacts with the phosphate backbone of the DNA occurring on the non-template strand ( xref – xref )."
27001517
MYSM1 affects apoptotic process
| 2 3
MYSM1 activates apoptotic process.
| 1 2
reach
"In addition, another study confirmed that the deletion MYSM1 restores dormant HSCs to a cyclic state and enhances apoptosis of HSCs, leading to depletion in the stem cell pool through blocked recruitment of the transcription factors GATA2 and RUNX1 to the GFI1 locus [XREF_BIBR]."
33327527
eidos
"MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3-phospho-BAD pathway ."
35217648
reach
"MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3-phospho-BAD pathway."
35217648
MYSM1 inhibits apoptotic process.
| 1 1
MYSM1 inhibits apoptotic process. 2 / 2
| 1 1
eidos
"Higher numbers of TUNEL-positive cells were observed in the liver of AAV9-Ctrl-treated mice compared to AAV9-Mysm1-treated mice ( Figure S11A , Supporting Information ) , confirming that MYSM1 suppresses DNA damage-induced senescence and apoptosis ."
33240758
reach
"Mechanistically, defective development of Mysm1-deficient mice correlated with altered gene transcription, increased apoptosis, and increased DNA damage in a variety of tissues, and was largely rescued by concomitant deletion of tumor suppressor p53 [38,42,43,44]."
32466590
MYSM1 affects aging process
| 5
MYSM1 inhibits aging process. 5 / 5
| 5
eidos
"MYSM1 mechanistically attenuates the aging process by promoting DNA repair processes ."
33240758
eidos
"MYSM1 functionally represses cellular senescence and the aging process by promoting DNA repair ."
33240758
eidos
"Functionally , MYSM1 functionally represses DDR-associated SASP and the aging process ."
33240758
eidos
"Whilst evaluating the molecular mechanisms underlying the MYSM1-mediated aging process , we revealed that MYSM1 represses cellular senescence and aging process by facilitation of HR DNA repair ."
33240758
eidos
"Mechanistically , MYSM1 represses the aging process by promoting homologous recombination ( HR ) mediated DNA repair ."
33240758
MYSM1 affects ZDHHC2
| 5
ZDHHC2 binds MYSM1. 5 / 5
| 5
sparser
"In further support of these findings, incubation of Ub-RIP2 immunoprecipitated from Mysm1 −/− BMDMs with Rec-MYSM1 resulted in diminished K63-, K27-, and M1-linked, but not K48-linked, ubiquitin chains (Supplementary Fig.  xref )."
30405132
sparser
"In contrast, Rec-MYSM1 had no effect on ubiquitin chains attached to NEMO (Supplementary Fig.  xref ), indicating that MYSM1 was selectively cleaving K63, K27, and M1, but not K48 linkages, from RIP2."
30405132
sparser
"Moreover, in vitro, Rec-MYSM1 could remove polyubiquitins from RIP2, but not NEMO (Supplementary Figure  xref )."
30405132
sparser
"Next we purified ubiquitin conjugates from L18-MDP-stimulated Mysm1 − /− BMDMs by TUBE and incubated them with recombinant MYSM1 (Rec-MYSM1) and compared the ubiquitin restriction pattern of Ub-RIP2 with that of AMSH, UCHL3, OTULIN or a combination of these three DUBs (Fig.  xref )."
30405132
sparser
"To gain a complete overview of the ubiquitin linkage specificity of MYSM1, we incubated Rec-MYSM1 with Di-ubiqutins (Ub 2 ) of different linkages."
30405132
MYSM1 affects RAP1
| 5
RAP1 binds MYSM1. 4 / 4
| 4
sparser
"By contrast, Rap1 binding to DNA through a single Myb-like domain results in formation of high stoichiometry complexes that act at DNA ends mostly in a Rif2-independent manner."
31879780
sparser
"Based on the available crystal structures, with such a short DNA duplex it is difficult to rationalize how Rap1 DBD would be able to bind with both Myb-like domains interacting with the DNA."
25637888
sparser
"In fact, a characterization of Rap1 mutant variants shows that Rap1 binding to DNA through both Myb-like domains results in formation of Rap1-DNA complexes that control MRX functions at both DSBs and telomeres primarily through Rif2."
31879780
sparser
"MRX association at DSBs is counteracted by Rif2, which is known to interact with Rap1 that binds telomeric DNA through two tandem Myb-like domains."
31879780
sparser
"For this orientation of the recognition sequence, Rap1 binds with the N-terminal Myb-like region of its DNA-binding domain (DBD) facing the incoming polymerase and with the majority of the Rap1 contacts with the phosphate backbone of the DNA occurring on the non-template strand ( xref – xref )."
27001517
H2AC20 affects MYSM1
3 | 2
MYSM1 binds H2AC20. 4 / 4
3 | 1
sparser
"In addition, as proof of principle of the co-IP approach, MYSM1 interaction with ubiquitinated histone H2A (H2Aub), a known substrate of the H2A deubiquitinase, was detectable in the anti-Flag pull-down from MYSM1-Flag transfectants, as expected ( xref C, lower panel)."
32466590
biogrid
No evidence text available
17707232
biogrid
No evidence text available
17707232
biogrid
No evidence text available
21245042
sparser
"In fact, MYSM1 is localized primarily to the nucleus and can directly interact with both H2A and H2B [ xref ]."
32708614
SMARCA4 affects SMARCA2
| 4
SMARCA2 binds SMARCA4 and MYSM1. 4 / 4
| 4
sparser
"An interaction of MYSM1 with the BRM and BRG1 components of the SWI/SNF chromatin remodeling complex was also suggested to have a role in the regulation of Ebf1 locus expression [ xref ]."
32344625
sparser
"To confirm the interaction of MYSM1 with BRM or BRG-1, we performed co-immunoprecipitation assays. xref show that MYSM1 was co-precipitated with endogenous BRM and BRG-1 in 293 cells that were transfected with the Flag-MYSM1 expression vector ( xref )."
22169041
sparser
"To further determine the association of MYSM1 and BRM or BRG-1 at the EBF1 promoter locus, sequential two-step ChIP assays were performed. xref shows the association of both MYSM1 and BRM and/or BRG-1 at the Ebf1 promoter locus of WT BM Lin − progenitors."
22169041
sparser
"Collectively, these data demonstrate that MYSM1 interacts with E2A and BRM and/or BRG-1 and its association is likely involved in MYSM1-mediated Ebf1 transcription in B-cell precursors."
22169041
reach
"MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS STING Pathway."
33086059
reach
"Thus, MYSM1 is a critical repressor of innate immunity and autoimmunity and is thus a potential therapeutic agent for infectious, inflammatory, and autoimmune diseases."
33086059
eidos
"MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway ."
33086059
reach
"This study identifies a distinct mechanism by which MYSM1 suppresses innate immunity and autoimmunity."
33086059
MYSM1 affects SMARCA4
| 4
SMARCA2 binds SMARCA4 and MYSM1. 4 / 4
| 4
sparser
"An interaction of MYSM1 with the BRM and BRG1 components of the SWI/SNF chromatin remodeling complex was also suggested to have a role in the regulation of Ebf1 locus expression [ xref ]."
32344625
sparser
"To confirm the interaction of MYSM1 with BRM or BRG-1, we performed co-immunoprecipitation assays. xref show that MYSM1 was co-precipitated with endogenous BRM and BRG-1 in 293 cells that were transfected with the Flag-MYSM1 expression vector ( xref )."
22169041
sparser
"To further determine the association of MYSM1 and BRM or BRG-1 at the EBF1 promoter locus, sequential two-step ChIP assays were performed. xref shows the association of both MYSM1 and BRM and/or BRG-1 at the Ebf1 promoter locus of WT BM Lin − progenitors."
22169041
sparser
"Collectively, these data demonstrate that MYSM1 interacts with E2A and BRM and/or BRG-1 and its association is likely involved in MYSM1-mediated Ebf1 transcription in B-cell precursors."
22169041
MYSM1 affects IRF8
| 3 1
MYSM1 activates IRF8.
| 2
MYSM1 activates IRF8. 2 / 2
| 2
reach
"We found that IRF2 and IRF8, which are important for HSC homeostasis and commitment as transcription repressors, were expressed at lower levels in Mysm1 -/- HSCs, and Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for HSC homeostasis."
27277682
reach
"The results showed that Mysm1 significantly enhances IRF2 and IRF8 promoter activity (-600 to +50) (XREF_SUPPLEMENTARY)."
27277682
MYSM1 decreases the amount of IRF8.
| 1
MYSM1 decreases the amount of IRF8. 1 / 1
| 1
reach
"Mysm1 deficiency reduces IRF2 and IRF8 expression in HSCs."
27277682
MYSM1 binds IRF8.
| 1
MYSM1 binds IRF8 and IRF2. 1 / 1
| 1
sparser
"We then tested Mysm1 binding to the promoter regions of IRF2 and IRF8 by analyzing WT (not Mysm1 −/− ) Lin − BM cells via a ChIP assay after in vitro stimulation with Poly(I:C) or IFN-γ."
27277682
MYSM1 affects IRF2
| 3 1
MYSM1 activates IRF2.
| 2
MYSM1 activates IRF2. 2 / 2
| 2
reach
"The results showed that Mysm1 significantly enhances IRF2 and IRF8 promoter activity (-600 to +50) (XREF_SUPPLEMENTARY)."
27277682
reach
"We found that IRF2 and IRF8, which are important for HSC homeostasis and commitment as transcription repressors, were expressed at lower levels in Mysm1 -/- HSCs, and Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for HSC homeostasis."
27277682
MYSM1 decreases the amount of IRF2.
| 1
MYSM1 decreases the amount of IRF2. 1 / 1
| 1
reach
"Mysm1 deficiency reduces IRF2 and IRF8 expression in HSCs."
27277682
MYSM1 binds IRF2.
| 1
MYSM1 binds IRF8 and IRF2. 1 / 1
| 1
sparser
"We then tested Mysm1 binding to the promoter regions of IRF2 and IRF8 by analyzing WT (not Mysm1 −/− ) Lin − BM cells via a ChIP assay after in vitro stimulation with Poly(I:C) or IFN-γ."
27277682
MYSM1 affects EBF1
| 2 2
MYSM1 binds EBF1.
| 2
MYSM1 binds EBF1. 2 / 2
| 2
sparser
"These data further demonstrate the direct association of MYSM1 with the Ebf1 promoter region in B-cells and their precursors."
22169041
sparser
"To probe the possible interaction of endogenous MYSM1 and the transcription factors of Ebf1 , we performed co-immunoprecipitation assays."
22169041
MYSM1 increases the amount of EBF1.
| 1
MYSM1 increases the amount of EBF1. 1 / 1
| 1
reach
"In an attempt to investigate how MYSM1 activates Ebf1 transcription, we first determined whether MYSM1 deubiquitinates ubH2A at the Ebf1 promoter locus of B-cell precursors."
22169041
MYSM1 activates EBF1.
| 1
MYSM1 activates EBF1. 1 / 1
| 1
reach
"BRM or BRG-1 silencing reduced MYSM1 mediated Ebf1 promoter transcription (XREF_SUPPLEMENTARY)."
22169041
EBF1 affects MYSM1
| 2 2
EBF1 increases the amount of MYSM1.
| 2
EBF1 increases the amount of MYSM1. 2 / 2
| 2
reach
"We identified the transcription factor EBF1 as a pivotal target gene of MYSM1 in lymphoid precursors and demonstrated that MYSM1 epigenetically de-represses EBF1 transcription by orchestrating histone modifications and regulating recruitment of the transcription factors to the EBF1 locus."
22169041
reach
"In an attempt to investigate how MYSM1 activates Ebf1 transcription, we first determined whether MYSM1 deubiquitinates ubH2A at the Ebf1 promoter locus of B-cell precursors."
22169041
EBF1 binds MYSM1.
| 2
MYSM1 binds EBF1. 2 / 2
| 2
sparser
"These data further demonstrate the direct association of MYSM1 with the Ebf1 promoter region in B-cells and their precursors."
22169041
sparser
"To probe the possible interaction of endogenous MYSM1 and the transcription factors of Ebf1 , we performed co-immunoprecipitation assays."
22169041
BBC3 affects MYSM1
| 2 2
BBC3 activates MYSM1.
| 2 1
BBC3 activates MYSM1. 3 / 3
| 2 1
reach
"XREF_BIBR, XREF_BIBR PUMA drives MPP cell depletion in Mysm1 deficiency."
26768662
sparser
"The downregulation of cell-cycle progression genes, together with the upregulation of p53 effectors in Mysm1 −/− Puma −/− MPPs further supports persistent stress-response activation in these cells."
26768662
reach
"Considering that Mysm1 -/- p53 -/- mice displayed complete rescue of hematopoietic dysfunction, 38 the other p53 effectors identified in our Mysm1 -/- Puma -/- transcriptome analysis may contribute to the PUMA independent but p53 dependent Mysm1 -/- phenotypes."
26768662
BBC3 binds MYSM1.
| 1
TP53 binds CDKN1A, BBC3, and MYSM1. 1 / 1
| 1
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 /PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a /p21."
26768662
Tamoxifen affects MYSM1
| 3
Tamoxifen activates MYSM1. 3 / 3
| 3
reach
"For tamoxifen induced Mysm1 gene inactivation in the Mysm1 flox and flox Gt (ROSA) 26Sor tm1 (cre and ERT2) mouse line, the mice were injected intraperitoneally with tamoxifen (T5648, Sigma, St. Louis, MO, USA) in sterilized corn oil (Sigma C8267) at 0.15 mg/g per injection, with eight doses in total administered over 16 days."
26768662
reach
"Mysm1 flox and flox line was generated by crossing Mysm1 tm1a mice to the Gt (ROSA) 26 Sor tm1 (FLP1) Dym and Wtsi line with ubiquitous expression of Flp recombinase, 56 and subsequently bred to Gt (ROSA) 26Sor tm1 (cre and ERT2) mice for tamoxifen induced Mysm1 inactivation."
26768662
reach
"14 The EuMyc mouse line was crossed to our established Mysm1 and Mysm1 Cre mouse lines, allowing either constitutive or tamoxifen‐induced Mysm1‐deletion."
34114734
Hsa-miR-8485 affects MYSM1
3 |
Hsa-miR-8485 decreases the amount of MYSM1. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
Benzo[a]pyrene affects MYSM1
3 |
Benzo[a]pyrene decreases the amount of MYSM1.
2 |
Benzo[a]pyrene decreases the amount of MYSM1. 2 / 2
2 |
ctd
No evidence text available
19770486
ctd
No evidence text available
21839799
Benzo[a]pyrene increases the amount of MYSM1.
1 |
Benzo[a]pyrene increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
22228805
RIPK2 affects NOD2
| 3
RIPK2 binds MYSM1 and NOD2. 2 / 2
| 2
sparser
"To explore further, we assessed by immunoprecipitation the interaction of MYSM1 with the other components in the NOD2:RIP2 complex."
30405132
sparser
"Importantly, LCL-161 did not abolish the enhanced MDP-induced NOD2:RIP2 complex assembly or phosphorylation of RIP2 and IKKα/β caused by MYSM1 deficiency (Supplementary Figure  xref )."
30405132
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
PU.1 affects MYSM1
| 3
MYSM1 binds PU.1. 2 / 2
| 2
sparser
"Consistent with earlier observations ( xref ), the association of MYSM1 and PU.1 with the Pax5 locus was not detected in WT plasma cells."
26348977
sparser
"Through the sequential two-step ChIP assays, we found that MYSM1 was associated with PU.1 at the Pax5 locus in naïve WT B cells ( xref )."
26348977
STAT5 binds IKZF1, MYSM1, Runx1, and PU.1. 1 / 1
| 1
sparser
"A weak association of endogenous MYSM1 protein and endogenous E2A (E47) protein was detected in WT BM Lin - progenitor cells, although the association of MYSM1 and PU.1, Ikaros, Stat5, or Runx1 was not positively identified (data not shown)."
22169041
NOD2 affects RIPK2
| 3
RIPK2 binds MYSM1 and NOD2. 2 / 2
| 2
sparser
"To explore further, we assessed by immunoprecipitation the interaction of MYSM1 with the other components in the NOD2:RIP2 complex."
30405132
sparser
"Importantly, LCL-161 did not abolish the enhanced MDP-induced NOD2:RIP2 complex assembly or phosphorylation of RIP2 and IKKα/β caused by MYSM1 deficiency (Supplementary Figure  xref )."
30405132
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
MYSM1 affects lifespan
| 3
MYSM1 activates lifespan. 3 / 3
| 3
eidos
"Mysm1 deficiency promotes aging and aging-related pathologies and reduces lifespan in mice ."
33240758
eidos
"Remarkably , MYSM1 deficiency facilitates the aging process and reduces lifespan , whereas MYSM1 over-expression attenuates the aging process and increases lifespan in mice ."
33240758
eidos
"MYSM1 deficiency facilitates the aging process and reduces lifespan , whereas MYSM1 over-expression attenuates aging and increases the lifespan of mice ( Figure 7 ) ."
33240758
MYSM1 affects lifespan mice
| 3
MYSM1 activates lifespan mice. 3 / 3
| 3
eidos
"These results confirmed that Mysm1 deficiency facilitates aging , development defects , and early death , reducing the lifespan of mice ."
33240758
eidos
"MYSM1 deficiency reduces the lifespan of mice ."
33240758
eidos
"Together , the findings demonstrated that Mysm1 deficiency promotes aging-related pathologies , facilitates developmental defects and early death , thereby shortening the lifespan of mice ."
33240758
MYSM1 affects hemopoiesis
| 3
MYSM1 inhibits hemopoiesis.
| 2
MYSM1 inhibits hemopoiesis. 2 / 2
| 2
reach
"Additionally, the lower representation of reverted circulating T cells might reflect a longer lifespan of the cells already present before the reversion compared with the other cell types analyzed.Our[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26220525
reach
"In addition, disorders mainly characterized by B alymphocytosis, T lymphopenia, and hematopoiesis impairment caused by MYSM1 deficiency were found in human subjects XREF_BIBR XREF_BIBR."
26915790
MYSM1 activates hemopoiesis.
| 1
MYSM1 activates hemopoiesis. 1 / 1
| 1
reach
"Assuming that the reversion mutation originated in a single HSC, we can conclude that restoration of MYSM1 function provided a very strong selective advantage and allowed one HSC clone to reconstitute normal wild-type hematopoiesis in competition with a large pool of MYSM1 deficient stem and progenitor cells."
32344625
MYSM1 affects RIPK2
| 3
RIPK2 binds MYSM1 and NOD2. 2 / 2
| 2
sparser
"To explore further, we assessed by immunoprecipitation the interaction of MYSM1 with the other components in the NOD2:RIP2 complex."
30405132
sparser
"Importantly, LCL-161 did not abolish the enhanced MDP-induced NOD2:RIP2 complex assembly or phosphorylation of RIP2 and IKKα/β caused by MYSM1 deficiency (Supplementary Figure  xref )."
30405132
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
MYSM1 affects PU.1
| 3
MYSM1 binds PU.1. 2 / 2
| 2
sparser
"Consistent with earlier observations ( xref ), the association of MYSM1 and PU.1 with the Pax5 locus was not detected in WT plasma cells."
26348977
sparser
"Through the sequential two-step ChIP assays, we found that MYSM1 was associated with PU.1 at the Pax5 locus in naïve WT B cells ( xref )."
26348977
STAT5 binds IKZF1, MYSM1, Runx1, and PU.1. 1 / 1
| 1
sparser
"A weak association of endogenous MYSM1 protein and endogenous E2A (E47) protein was detected in WT BM Lin - progenitor cells, although the association of MYSM1 and PU.1, Ikaros, Stat5, or Runx1 was not positively identified (data not shown)."
22169041
MYSM1 affects NOD2
| 3
RIPK2 binds MYSM1 and NOD2. 2 / 2
| 2
sparser
"To explore further, we assessed by immunoprecipitation the interaction of MYSM1 with the other components in the NOD2:RIP2 complex."
30405132
sparser
"Importantly, LCL-161 did not abolish the enhanced MDP-induced NOD2:RIP2 complex assembly or phosphorylation of RIP2 and IKKα/β caused by MYSM1 deficiency (Supplementary Figure  xref )."
30405132
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
MYSM1 affects MYSM1
| 3
MYSM1 activates MYSM1.
| 2
MYSM1 activates MYSM1. 2 / 2
| 2
reach
"Loss of Mysm1 Causes Skin Atrophy and Reduced Skin Cellularity in Mysm1 Deficient Mice."
29495602
reach
"XREF_FIG shows that forced expression of MYSM1, but not control, rescued the enhanced plasma cell differentiation of Mysm1 -/- B cells."
26348977
MYSM1 decreases the amount of MYSM1.
| 1
MYSM1 decreases the amount of MYSM1. 1 / 1
| 1
reach
"Western blot analysis showed that MYSM1 siRNA significantly reduced the expression of MYSM1 protein compared with siRNA non transfected or control siRNA transfected SW480 cells (XREF_FIG)."
28498834
MYSM1 affects Ig
| 3
MYSM1 inhibits Ig. 3 / 3
| 3
reach
"Thus, these data demonstrate that MYSM1 represses plasma cell differentiation, as well as Ig production by plasma cells."
26348977
reach
"MYSM1 intrinsically represses Ig production by plasma cells."
26348977
reach
"To investigate the mechanism by which MYSM1 represses plasma cell generation and Ig production, we first examined the expression of a set of transcriptional factors that are critical for plasma cell generation and Ig production XREF_BIBR XREF_BIBR XREF_BIBR by qRT-PCR assays."
26348977
MYSM1 affects Histone
| 1 2
MYSM1 binds Histone.
| 2
Histone binds MYSM1. 2 / 2
| 2
sparser
"The SWIRM domain of MYSM1, in contrast, does not have direct DNA binding activity [ xref ], and although it is a common domain-type for chromatin-associated proteins [ xref , xref ], it was shown to be dispensable for MYSM1 interactions with histones, at least in some systems [ xref ]."
32344625
sparser
"These data suggest that MYSM1 interacts with other histone modifiers to regulate chromatin status at the Ebf1 locus."
22169041
MYSM1 inhibits Histone.
| 1
MYSM1 inhibits Histone. 1 / 1
| 1
reach
"53 Our work shows that MYSM1 represses p53 stress response genes by antagonizing other histone modifications (H3K27ac and H3K4me3)."
26768662
MYSM1 affects His2A
| 3
MYSM1 deubiquitinates His2A.
| 2
MYSM1 deubiquitinates His2A. 2 / 2
| 2
reach
"In contrast, there was no apparent difference in ubH2A in EBF1 promoter desert region (PDR) and exon 2 regions, as well as in the osteocalcin (OC) promoter locus of WT and Mysm1 -/- Lin - progenitors, suggesting the selective deubiquitination of uH2A at the Ebf1 locus by MYSM1."
22169041
reach
"Significantly, although cells were treated with DHT as usual, the amount of pS5-Pol II on the promoter was reduced upon loss of 2A-DUB and increased levels of uH2A, which argues that 2A-DUB and result[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
MYSM1 decreases the amount of His2A.
| 1
MYSM1 decreases the amount of His2A. 1 / 1
| 1
reach
"WT 2A-DUB substantially decreased uH2A levels, whereas the D567N mutant, in which the key aspartic acid residue required for the metal-binding-dependent deubiquitinase activity was substituted to a no[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
MYSM1 affects HELLS
| 3
MYSM1 binds HELLS. 2 / 2
| 2
sparser
"Therefore, the potential role of the MYSM1-RFC-HELLS interaction in DNA repair and genome integrity will now need to be verified in tumor samples at different tumor stages and in response to treatment."
32466590
sparser
"However, in melanoma cells, MYSM1 was not found in proximity to either HH3 or Ki-67 in heterochromatin during cell cycle [ xref ], warranting more detailed analyses of the putative function of the MYSM1-HELLS interaction in DDR and gene transcription."
32466590
MYSM1 binds HELLS, PCNA, and RFC5. 1 / 1
| 1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
32466590
Treatments DOX affects MYSM1
| 2
Treatments DOX inhibits MYSM1.
| 1
Treatments DOX inhibits MYSM1. 1 / 1
| 1
eidos
"In human primary diploid fibroblasts ( WI-38 ) , treatments with ETO and DOX increased Mysm1 expression after 2 and 5 days , but decreased Mysm1 expression at 8 days ( Figure S2A , B , Supporting Information ) ."
33240758
Treatments DOX activates MYSM1.
| 1
Treatments DOX activates MYSM1. 1 / 1
| 1
eidos
"In human primary diploid fibroblasts ( WI-38 ) , treatments with ETO and DOX increased Mysm1 expression after 2 and 5 days , but decreased Mysm1 expression at 8 days ( Figure S2A , B , Supporting Information ) ."
33240758
End3 affects MYSM1
| 2
MYSM1 binds end3. 2 / 2
| 2
reach
"USP22 and 2A-DUB are enzymatically active as part of the SAGA and 2A-DUB complexes respectively [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
20974139
reach
"Both the 2A-DUB and SAGA complexes also harbor histone acetyltransferase (HAT) subunits, PCAF and its homologue GCN5, respectively."
20974139
Bisphenol A affects MYSM1
2 |
Bisphenol A decreases the amount of MYSM1. 2 / 2
2 |
ctd
No evidence text available
30816183
ctd
No evidence text available
25181051
TMPRSS11D affects MYSM1
| 2
USP22 binds TMPRSS11D and MYSM1. 1 / 1
| 1
sparser
"The finding that two DUBs, 2A-DUB and USP22 associate with HATs suggests an important functional interplay between these classes of enzymes."
18430235
TMPRSS11D binds MYSM1. 1 / 1
| 1
sparser
"To test whether p/CAF, a HAT that interacts with 2A-DUB and augments the H2A deubiquitinase activity of 2A-DUB ( Figures 2 and 3 ), plays a role in 2A-DUB-dependent activation, we compared 2A-DUB-indu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
SPI1 affects MYSM1
| 1 1
SPI1 binds MYSM1. 2 / 2
| 1 1
sparser
"MYSM1 interacts with the transcription factor PU.1 for its recruitment to the Pax5 locus."
26348977
reach
"MYSM1 interacts with the transcription factor PU.1 for its recruitment to the Pax5 locus."
26348977
RNF31 affects MYSM1
| 2
RNF31 binds TAB2, MYSM1, and TAB3. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
RBM10 affects MYSM1
1 | 1
MYSM1 binds RBM10. 2 / 2
1 | 1
biogrid
No evidence text available
17707232
sparser
"Our transcriptomic analyses, which show no effect of RBM10 downregulation on alternative splicing in GLC20 cells, are supported by (1) our RBM10-only targets ( xref ), which are involved in various aspects of gene expression regulation, excluding alternative splicing, (2) RBM10’s mRNA stabilization effect on its only identified direct RNA target, the AT1 receptor [ xref ], and (3) RBM10’s interaction with the 2A-DUB deubiquitinase protein complex [ xref ] and the Rac-specific GTPase-activitating protein FilGAP [ xref ]."
28662214
PAX5 affects MYSM1
| 2
PAX5 increases the amount of MYSM1.
| 1
PAX5 increases the amount of MYSM1. 1 / 1
| 1
reach
"Mechanistic studies revealed that MYSM1 activates Pax5 transcription by coordinating histone modifications and directing the recruitment of the transcription activators such as PU.1 to the Pax5 locus in B cells."
26348977
PAX5 activates MYSM1.
| 1
PAX5 activates MYSM1. 1 / 1
| 1
reach
"XREF_FIG shows that mRNA levels of Pax5 and Bach2 were significantly reduced, while Blimp1 and Xbp1 mRNA levels were significantly elevated in naive and activated Mysm1 -/- B cells."
26348977
PAX3 affects MYSM1
| 1 1
MYSM1 binds PAX3. 2 / 2
| 1 1
sparser
"No significant binding of MYSM1 to either the PAX3 or the ETS1 promoter sequence around the transcriptional start site (TSS) could be detected in comparison to IgG controls."
28978033
reach
"In context with our finding that MYSM1 bound to the c-MET promoter region in close vicinity to PAX3 in melanoma cells, our data indicate that MYSM1 is an epigenetic regulator of melanoma growth and potentially promising new target for tumor therapy."
28978033
reach
"Furthermore, silencing MYSM1 stimulated PI3K/AKT signaling and promoted EMT in CRC cells."
34706761
reach
"MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling."
34706761
MYSM1 affects miR-200
| 2
MYSM1 inhibits miR-200.
| 1
MYSM1 inhibits miR-200. 1 / 1
| 1
reach
"MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling."
34706761
MYSM1 increases the amount of miR-200.
| 1
MYSM1 increases the amount of miR-200. 1 / 1
| 1
reach
"Mechanistically, MYSM1 directly bound to the promoter region of miR-200/CDH1, impaired the enrichment of repressive H2AK119ub1 modification and epigenetically enhanced miR-200/CDH1 expression."
34706761
MYSM1 affects histone H2AK119ub
| 2
MYSM1 inhibits histone H2AK119ub. 2 / 2
| 2
eidos
"At many of these loci , loss of MYSM1 resulted in increased binding of PRC1 complex proteins and elevated levels of histone H2AK119ub [ 20,30,32,33,34 ] , suggesting that MYSM1 antagonizes PRC1-mediated histone ubiquitination and transcriptional repression ."
32344625
eidos
"MYSM1 was required for normal recruitment of transcription factors GATA2 and RUNX1 to the Gfi1 locus , while loss of MYSM1 resulted in increased recruitment of the PRC1 complex proteins RING1B and BMI1 and increased levels of histone H2AK119ub [ 34 ] ( Figure 2 ) ."
32344625
MYSM1 affects end3
| 2
MYSM1 binds end3. 2 / 2
| 2
reach
"USP22 and 2A-DUB are enzymatically active as part of the SAGA and 2A-DUB complexes respectively [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
20974139
reach
"Both the 2A-DUB and SAGA complexes also harbor histone acetyltransferase (HAT) subunits, PCAF and its homologue GCN5, respectively."
20974139
MYSM1 inhibits deoxyribonucleic acid. 2 / 2
| 2
eidos
"C-E ) WT MEFs and Mysm1 - / - MEFs ( C , D ) or WT MEFs , Mysm1 - / - MEFs , and Mysm1 - / - MEFs transfected with Flag-Mysm1 ( E ) were treated with DOX to induce DNA damage ."
33240758
eidos
"Our data revealed a distinct mechanism through which MYSM1 eliminates DNA damage by promoting DNA repair to suppress senescence and the aging processes ."
33240758
MYSM1 affects cellular senescence aging process human mice primary cells mice organs
| 2
MYSM1 inhibits cellular senescence aging process human mice primary cells mice organs. 2 / 2
| 2
eidos
"Detailed functional analyses confirmed that MYSM1 represses cellular senescence and the aging process in human and mice primary cells and in mice organs ."
33240758
eidos
"MYSM1 functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs ."
33240758
MYSM1 affects cell quiescence
| 2
MYSM1 inhibits cell quiescence. 2 / 2
| 2
reach
"33 Using Ki67 as a marker of non quiescent cells, we show that Mysm1 -/- HSC loss of quiescence is rescued in Mysm1 -/- p53 -/- HSCs (XREF_FIG, right)."
26768662
reach
"Overall, this suggests that continued dysregulation of p53 effector functions beyond the upregulation of Bbc3 and PUMA contributes to persistent Mysm1 -/- HSC loss of quiescence, and also to the lymphoid differentiation arrest of Mysm1 -/- Puma -/- MPP4s."
26768662
MYSM1 affects TMPRSS11D
| 2
USP22 binds TMPRSS11D and MYSM1. 1 / 1
| 1
sparser
"The finding that two DUBs, 2A-DUB and USP22 associate with HATs suggests an important functional interplay between these classes of enzymes."
18430235
TMPRSS11D binds MYSM1. 1 / 1
| 1
sparser
"To test whether p/CAF, a HAT that interacts with 2A-DUB and augments the H2A deubiquitinase activity of 2A-DUB ( Figures 2 and 3 ), plays a role in 2A-DUB-dependent activation, we compared 2A-DUB-indu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
MYSM1 affects SPI1
| 1 1
SPI1 binds MYSM1. 2 / 2
| 1 1
sparser
"MYSM1 interacts with the transcription factor PU.1 for its recruitment to the Pax5 locus."
26348977
reach
"MYSM1 interacts with the transcription factor PU.1 for its recruitment to the Pax5 locus."
26348977
MYSM1 affects RNF31
| 2
RNF31 binds TAB2, MYSM1, and TAB3. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
MYSM1 affects RNF2
| 1 1
MYSM1 inhibits RNF2.
| 1
MYSM1 inhibits RNF2. 1 / 1
| 1
reach
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
MYSM1 binds RNF2.
| 1
RNF2 binds BMI1, MYSM1, and PRC1. 1 / 1
| 1
sparser
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
MYSM1 affects RBM10
1 | 1
MYSM1 binds RBM10. 2 / 2
1 | 1
biogrid
No evidence text available
17707232
sparser
"Our transcriptomic analyses, which show no effect of RBM10 downregulation on alternative splicing in GLC20 cells, are supported by (1) our RBM10-only targets ( xref ), which are involved in various aspects of gene expression regulation, excluding alternative splicing, (2) RBM10’s mRNA stabilization effect on its only identified direct RNA target, the AT1 receptor [ xref ], and (3) RBM10’s interaction with the 2A-DUB deubiquitinase protein complex [ xref ] and the Rac-specific GTPase-activitating protein FilGAP [ xref ]."
28662214
MYSM1 affects PI3K
| 2
MYSM1 inhibits PI3K. 2 / 2
| 2
reach
"MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling."
34706761
reach
"Furthermore, silencing MYSM1 stimulated PI3K/AKT signaling and promoted EMT in CRC cells."
34706761
MYSM1 affects PAX3
| 1 1
MYSM1 binds PAX3. 2 / 2
| 1 1
sparser
"No significant binding of MYSM1 to either the PAX3 or the ETS1 promoter sequence around the transcriptional start site (TSS) could be detected in comparison to IgG controls."
28978033
reach
"In context with our finding that MYSM1 bound to the c-MET promoter region in close vicinity to PAX3 in melanoma cells, our data indicate that MYSM1 is an epigenetic regulator of melanoma growth and potentially promising new target for tumor therapy."
28978033
MYSM1 affects NOD2, and RIPK2
| 2
RIPK2 binds MYSM1 and NOD2. 2 / 2
| 2
sparser
"To explore further, we assessed by immunoprecipitation the interaction of MYSM1 with the other components in the NOD2:RIP2 complex."
30405132
sparser
"Importantly, LCL-161 did not abolish the enhanced MDP-induced NOD2:RIP2 complex assembly or phosphorylation of RIP2 and IKKα/β caused by MYSM1 deficiency (Supplementary Figure  xref )."
30405132
MYSM1 affects MET
| 2
MYSM1 binds MET. 2 / 2
| 2
sparser
"In support of a collaboration of MYSM1 with PAX3 in transcriptional regulation, MYSM1 binding to the c-MET promoter in melanoma cells occurred in vicinity to the PAX3 consensus sequence previously described [ xref ]."
28978033
sparser
"In context with our finding that MYSM1 bound to the c-MET promoter region in close vicinity to PAX3 in melanoma cells, our data indicate that MYSM1 is an epigenetic regulator of melanoma growth and potentially promising new target for tumor therapy."
28978033
MYSM1 affects IL3
| 1 1
MYSM1 binds IL3. 2 / 2
| 1 1
sparser
"MYSM1 interacts with nuclear factor IL-3 (NFIL3, also known as E4BP4), a critical factor for mouse NK cell development, and the recruitment of nuclear factor Il-3 to the ID2 locus is dependent on MYSM1."
24062447
reach
"MYSM1 interacts with nuclear factor IL-3 (NFIL3, also known as E4BP4), a critical factor for mouse NK cell development, and the recruitment of nuclear factor Il-3 to the ID2 locus is dependent on MYSM1."
24062447
MYSM1 affects IFN-I
| 2
MYSM1 inhibits IFN-I.
| 1
MYSM1 inhibits IFN-I. 1 / 1
| 1
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
MYSM1 activates IFN-I.
| 1
MYSM1 activates IFN-I. 1 / 1
| 1
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
MYSM1 affects Histone_H2B
| 1 1
reach
"It would be intriguing to examine whether MYSM1 could associate with ubiquitinated chromatin proteins, such as histones H2A and H2B."
17428495
sparser
"In fact, MYSM1 is localized primarily to the nucleus and can directly interact with both H2A and H2B [ xref ]."
32708614
MYSM1 affects HTH
| 2
MYSM1 binds PAC and HTH. 1 / 1
| 1
sparser
"An unexpectedly potent size regulator that emerged from our screens was Dot6, a Myb-like HTH transcription factor that binds to the PAC (Polymerase A and C) motif [ xref ]."
30921326
MYSM1 binds MYB and HTH. 1 / 1
| 1
sparser
"Both genes contained two introns, encoded 257 amino acids with two-Aa difference, and carried the unabridged HTH-MYB, MYB-like DNA-binding, and SANT domains."
31035916
MYSM1 affects FLT3
| 1 1
MYSM1 decreases the amount of FLT3.
| 1
Modified MYSM1 decreases the amount of FLT3. 1 / 1
| 1
reach
"We then demonstrated that ectopic expression of both miR-150 and MYSM1 in MYSM1 -/- B1a cells reduced the level of FLT3."
27590507
MYSM1 binds FLT3.
| 1
MYSM1 binds FLT3. 1 / 1
| 1
sparser
"MYSM1 bound to the Flt3 gene promoter, and loss of MYSM1 resulted in reduced recruitment of the major hematopoietic transcription factor PU.1 and an increase in repressive histone marks H2AK119ub and H3K27me3 at the Flt3 locus [ xref ] ( xref )."
32344625
MYSM1 affects EP300
| 2
CREBBP binds MYSM1 and EP300. 2 / 2
| 2
sparser
"2A-DUB associates with histone acetyltransferase p300/CBP-associated factor (PCAF/KAT2B) in a coregulatory protein complex and regulates transcription by coordinating histone acetylating, deubiquitina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18929679
sparser
"2A-DUB associates with the histone acetyltransferase p300/CBP-associated factor (p/CAF), a complex that mediates acetylation of histones H3 and H4 in transcriptionally active chromatin ( xref )."
19489724
MYSM1 affects DREB2A
| 2
TCEA1 binds MED25, MYSM1, and DREB2A. 1 / 1
| 1
sparser
"MED25 physically interacts with abiotic-stress associated TFs, DREB2A, ZFHD1, and MYB-Like ( xref ;Table xref )."
28659948
MYSM1 binds DREB2A. 1 / 1
| 1
sparser
"We recently identified mediator in Arabidopsis thaliana and we have also reported that the Med25 subunit in Arabidopsis interacts with three different transcription factors, Dreb2a, Zfhd1 and myb-like which all are involved in different stress response pathways ( xref , xref ) In this article, we use a set of biochemical and biophysical methods to study interaction between the Med25 mediator subunit and the transcription factor Dreb2a from A. thaliana ."
22447446
MYSM1 affects DNA repair
| 1 1
MYSM1 inhibits DNA repair.
| 1
MYSM1 inhibits DNA repair. 1 / 1
| 1
reach
"MYSM1 mechanistically attenuates the aging process by promoting DNA repair processes."
33240758
MYSM1 activates DNA repair.
| 1
MYSM1 activates DNA repair. 1 / 1
| 1
eidos
"Collectively , these results revealed that MYSM1 deficiency represses DNA repair , whereas MYSM1 over-expression promotes DNA repair ."
33240758
MYSM1 affects DNA accumulation
| 2
MYSM1 inhibits DNA accumulation. 2 / 2
| 2
eidos
"Taken together , the results demonstrate that MYSM1 prevents DNA damage accumulation by facilitating HR mediated DNA repair ."
33240758
eidos
"Together , the results suggested that Mysm1 expression is associated with senescence , and that MYSM1 prevents DNA damage accumulation to suppress senescence and aging by facilitating the HR mediated DNA repair ."
33240758
MYSM1 affects DDR-associated SASP
| 2
MYSM1 inhibits DDR-associated SASP. 2 / 2
| 2
eidos
"MYSM1 suppresses DDR-associated SASP ."
33240758
eidos
"Taken together , these results showed that MYSM1 represses DDR-associated SASP ."
33240758
MYSM1 affects CREBBP
| 2
CREBBP binds MYSM1 and EP300. 2 / 2
| 2
sparser
"2A-DUB associates with histone acetyltransferase p300/CBP-associated factor (PCAF/KAT2B) in a coregulatory protein complex and regulates transcription by coordinating histone acetylating, deubiquitina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18929679
sparser
"2A-DUB associates with the histone acetyltransferase p300/CBP-associated factor (p/CAF), a complex that mediates acetylation of histones H3 and H4 in transcriptionally active chromatin ( xref )."
19489724
MYSM1 affects CLOCK
| 2
CLOCK binds MYSM1. 2 / 2
| 2
sparser
"In Arabidopsis, the first-identified clock genes function in a double negative feedback loop, with two morning-phased Myb-like transcription factors, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), repressing expression of an evening-phased pseudo-response regulator, TIMING OF CAB EXPRESSION 1 (TOC1 or PRR1), which in turn represses expression of CCA1 and LHY ( xref ; xref ; xref ; xref ; xref ; xref ; xref )."
23638299
sparser
"When we used all 2364 arrays, strong positive correlation between two Myb-like transcription factor genes, Circadian Clock Associated 1 ( CCA1 ) and Late Elongated Hypocotyl ( LHY ) was observed, as well as weak negative correlation between Timing Of Cab expression 1 ( TOC1 ) and LHY , and between TOC1 and CCA1 (Fig.  xref A–C and Table  xref )."
18931094
MYSM1 affects CDH1
| 2
MYSM1 inhibits CDH1.
| 1
MYSM1 inhibits CDH1. 1 / 1
| 1
reach
"MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling."
34706761
MYSM1 decreases the amount of CDH1.
| 1
MYSM1 decreases the amount of CDH1. 1 / 1
| 1
reach
"Mechanistically, MYSM1 directly bound to the promoter region of miR-200/CDH1, impaired the enrichment of repressive H2AK119ub1 modification and epigenetically enhanced miR-200/CDH1 expression."
34706761
MYSM1 affects BMI1
| 1 1
MYSM1 inhibits BMI1.
| 1
MYSM1 inhibits BMI1. 1 / 1
| 1
reach
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
MYSM1 binds BMI1.
| 1
RNF2 binds BMI1, MYSM1, and PRC1. 1 / 1
| 1
sparser
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
MYSM1 affects BBC3
| 1 1
MYSM1 inhibits BBC3.
| 1
MYSM1 inhibits BBC3. 1 / 1
| 1
reach
"Repression of p53-target gene Bbc3 and PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance."
26768662
MYSM1 binds BBC3.
| 1
TP53 binds CDKN1A, BBC3, and MYSM1. 1 / 1
| 1
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 /PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a /p21."
26768662
MYSM1 affects ARF
| 1 1
MYSM1 inhibits ARF.
| 1
MYSM1 inhibits ARF. 1 / 1
| 1
reach
"As Mysm1 generally functions as a transcription activator, it is rational to postulate that Mysm1 suppresses p53 or p19 ARF likely by activating expression of transcription repressors."
27277682
MYSM1 binds ARF.
| 1
TP53 binds MYSM1 and ARF. 1 / 1
| 1
sparser
"In line with a previous report on Mysm1-binding to thep19 ARF -promoter in thymocytes [ xref ], an upstream regulator of TS p53, in Mysm1 −/− epidermal cells as well, mRNA expression ofp19 ARF was moderately increased along with increases in p53 levels and in apoptosis."
29495602
MET affects MYSM1
| 2
MYSM1 binds MET. 2 / 2
| 2
sparser
"In support of a collaboration of MYSM1 with PAX3 in transcriptional regulation, MYSM1 binding to the c-MET promoter in melanoma cells occurred in vicinity to the PAX3 consensus sequence previously described [ xref ]."
28978033
sparser
"In context with our finding that MYSM1 bound to the c-MET promoter region in close vicinity to PAX3 in melanoma cells, our data indicate that MYSM1 is an epigenetic regulator of melanoma growth and potentially promising new target for tumor therapy."
28978033
IL3 affects MYSM1
| 1 1
MYSM1 binds IL3. 2 / 2
| 1 1
sparser
"MYSM1 interacts with nuclear factor IL-3 (NFIL3, also known as E4BP4), a critical factor for mouse NK cell development, and the recruitment of nuclear factor Il-3 to the ID2 locus is dependent on MYSM1."
24062447
reach
"MYSM1 interacts with nuclear factor IL-3 (NFIL3, also known as E4BP4), a critical factor for mouse NK cell development, and the recruitment of nuclear factor Il-3 to the ID2 locus is dependent on MYSM1."
24062447
Histone_H2B affects MYSM1
| 1 1
reach
"It would be intriguing to examine whether MYSM1 could associate with ubiquitinated chromatin proteins, such as histones H2A and H2B."
17428495
sparser
"In fact, MYSM1 is localized primarily to the nucleus and can directly interact with both H2A and H2B [ xref ]."
32708614
Histone affects MYSM1
| 2
Histone binds MYSM1. 2 / 2
| 2
sparser
"The SWIRM domain of MYSM1, in contrast, does not have direct DNA binding activity [ xref ], and although it is a common domain-type for chromatin-associated proteins [ xref , xref ], it was shown to be dispensable for MYSM1 interactions with histones, at least in some systems [ xref ]."
32344625
sparser
"These data suggest that MYSM1 interacts with other histone modifiers to regulate chromatin status at the Ebf1 locus."
22169041
HTH affects MYSM1
| 2
MYSM1 binds PAC and HTH. 1 / 1
| 1
sparser
"An unexpectedly potent size regulator that emerged from our screens was Dot6, a Myb-like HTH transcription factor that binds to the PAC (Polymerase A and C) motif [ xref ]."
30921326
MYSM1 binds MYB and HTH. 1 / 1
| 1
sparser
"Both genes contained two introns, encoded 257 amino acids with two-Aa difference, and carried the unabridged HTH-MYB, MYB-like DNA-binding, and SANT domains."
31035916
EP300 affects MYSM1
| 2
CREBBP binds MYSM1 and EP300. 2 / 2
| 2
sparser
"2A-DUB associates with histone acetyltransferase p300/CBP-associated factor (PCAF/KAT2B) in a coregulatory protein complex and regulates transcription by coordinating histone acetylating, deubiquitina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18929679
sparser
"2A-DUB associates with the histone acetyltransferase p300/CBP-associated factor (p/CAF), a complex that mediates acetylation of histones H3 and H4 in transcriptionally active chromatin ( xref )."
19489724
DREB2A affects MYSM1
| 2
TCEA1 binds MED25, MYSM1, and DREB2A. 1 / 1
| 1
sparser
"MED25 physically interacts with abiotic-stress associated TFs, DREB2A, ZFHD1, and MYB-Like ( xref ;Table xref )."
28659948
MYSM1 binds DREB2A. 1 / 1
| 1
sparser
"We recently identified mediator in Arabidopsis thaliana and we have also reported that the Med25 subunit in Arabidopsis interacts with three different transcription factors, Dreb2a, Zfhd1 and myb-like which all are involved in different stress response pathways ( xref , xref ) In this article, we use a set of biochemical and biophysical methods to study interaction between the Med25 mediator subunit and the transcription factor Dreb2a from A. thaliana ."
22447446
CREBBP affects MYSM1
| 2
CREBBP binds MYSM1 and EP300. 2 / 2
| 2
sparser
"2A-DUB associates with histone acetyltransferase p300/CBP-associated factor (PCAF/KAT2B) in a coregulatory protein complex and regulates transcription by coordinating histone acetylating, deubiquitina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18929679
sparser
"2A-DUB associates with the histone acetyltransferase p300/CBP-associated factor (p/CAF), a complex that mediates acetylation of histones H3 and H4 in transcriptionally active chromatin ( xref )."
19489724
CLOCK affects MYSM1
| 2
CLOCK binds MYSM1. 2 / 2
| 2
sparser
"In Arabidopsis, the first-identified clock genes function in a double negative feedback loop, with two morning-phased Myb-like transcription factors, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), repressing expression of an evening-phased pseudo-response regulator, TIMING OF CAB EXPRESSION 1 (TOC1 or PRR1), which in turn represses expression of CCA1 and LHY ( xref ; xref ; xref ; xref ; xref ; xref ; xref )."
23638299
sparser
"When we used all 2364 arrays, strong positive correlation between two Myb-like transcription factor genes, Circadian Clock Associated 1 ( CCA1 ) and Late Elongated Hypocotyl ( LHY ) was observed, as well as weak negative correlation between Timing Of Cab expression 1 ( TOC1 ) and LHY , and between TOC1 and CCA1 (Fig.  xref A–C and Table  xref )."
18931094
Vincristine affects MYSM1
1 |
Vincristine increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
23649840
Valproic acid affects MYSM1
1 |
Valproic acid decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
23179753
Tungsten affects MYSM1
1 |
Tungsten decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
30912803
Troglitazone affects MYSM1
1 |
Troglitazone decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
28973697
Transferase affects MYSM1
| 1
MYSM1 binds transferase. 1 / 1
| 1
sparser
"2A-DUB is associated with the p/CAF histone acetyl transferase."
18430235
Thrb affects MYSM1
| 1
MYSM1 binds thrb. 1 / 1
| 1
sparser
"TRB proteins bind specifically telomeric double strand DNA through their myb-like domain of a telobox type [ xref , xref ], as well as the human core components of shelterin—TRF1 and TRF2 proteins."
30654521
Thapsigargin affects MYSM1
1 |
Thapsigargin increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
24648495
Testosterone undecanoate decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
19074003
Sunitinib affects MYSM1
1 |
Sunitinib increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
31533062
Sulforaphane affects MYSM1
1 |
Sulforaphane decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
30529165
Str affects MYSM1
| 1
MYSM1 binds str. 1 / 1
| 1
sparser
"CrBPF1 was identified as a MYB-like protein that binds the BA region of the C. roseus STR promoter ( xref )."
26483828
Sodium arsenate affects MYSM1
1 |
Sodium arsenate increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
21795629
Response to hypoxia affects MYSM1
1 |
Response to hypoxia decreases the amount of MYSM1. 1 / 1
1 |
bel
"Upon hypoxia, the expression of HIF-1alpha and VEGF gene was induced. The result of Western blotting showed that the expression of alpha-SMA was increased by hypoxic stimulation. Furthermore, the expression of MMP-2 and TIMP-1 genes was increased. Hypoxia also elevated the protein expression of the collagen type I in LX-2 cells. The analysis of TGF-beta/Smad signaling pathway showed that hypoxia potentiated the expression of TGF-beta1 and the phosphorylation status of Smad2. See Table 2 for results of microarray experiment."
17187782
Propiconazole affects MYSM1
1 |
Propiconazole decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
21278054
Progesterone affects MYSM1
1 |
Progesterone decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
19690047
Potassium chromate increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
22079256
P53-target gene promoters affects MYSM1
| 1
MYSM1 binds p53-target gene promoters. 1 / 1
| 1
reach
"The recruitment of MYSM1 to p53-target gene promoters was tested using chromatin immunoprecipitation (ChIP) in a Ba/F3 hematopoietic progenitor cell line stably expressing FLAG-MYSM1 (XREF_SUPPLEMENTARY)."
26768662
P16 INK4a mRNA affects MYSM1
| 1
P16 INK4a mRNA activates MYSM1. 1 / 1
| 1
reach
"In contrast to p19 ARF, p16 INK4a mRNA was only slightly induced in Mysm1 deficient thymocytes (XREF_FIG (left) and XREF_FIG)."
25613381
NmoT affects MYSM1
| 1
MYSM1 binds nmoT. 1 / 1
| 1
sparser
"The Myb-like protein is required for transposition and physically interacts with the N-terminal region of the transposase via its C-terminal domain."
18339812
Miconazole affects MYSM1
1 |
Miconazole decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
27462272
Methyl methanesulfonate increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
23649840
Levonorgestrel affects MYSM1
1 |
Levonorgestrel decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
19074003
Jinfukang affects MYSM1
1 |
Jinfukang decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
27392435
Irinotecan affects MYSM1
1 |
Irinotecan decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
18927307
Hsa-miR-484 affects MYSM1
1 |
Hsa-miR-484 decreases the amount of MYSM1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-376b-3p affects MYSM1
1 |
Hsa-miR-376b-3p decreases the amount of MYSM1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-376a-3p affects MYSM1
1 |
Hsa-miR-376a-3p decreases the amount of MYSM1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-186-5p affects MYSM1
1 |
Hsa-miR-186-5p decreases the amount of MYSM1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Formaldehyde affects MYSM1
1 |
Formaldehyde increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
20655997
Endosulfan affects MYSM1
1 |
Endosulfan increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
26615145
Doxorubicin affects MYSM1
1 |
Doxorubicin decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
29803840
Dorsomorphin affects MYSM1
| 1
Dorsomorphin inhibits MYSM1. 1 / 1
| 1
reach
"Pifithrin α (PFT α) and Compound C, antagonists of p53 and AMPK, respectively, repressed ATP production and reversed the antidepressant effect of Mysm1 knockdown."
36414403
Dichloromethane affects MYSM1
1 |
Dichloromethane decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
28392392
Diazinon affects MYSM1
1 |
Diazinon increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
29108742
Cerium trichloride increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
23573234
Carbon nanotube affects MYSM1
1 |
Carbon nanotube decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
25554681
C-MET promoter affects MYSM1
| 1
MYSM1 binds c-MET promoter. 1 / 1
| 1
reach
"In support of a collaboration of MYSM1 with PAX3 in transcriptional regulation, MYSM1 binding to the c-MET promoter in melanoma cells occurred in vicinity to the PAX3 consensus sequence previously described [XREF_BIBR]."
28978033
C-MET promoter region affects MYSM1
| 1
MYSM1 binds c-MET promoter region. 1 / 1
| 1
reach
"In context with our finding that MYSM1 bound to the c-MET promoter region in close vicinity to PAX3 in melanoma cells, our data indicate that MYSM1 is an epigenetic regulator of melanoma growth and potentially promising new target for tumor therapy."
28978033
C-MET promoter region affects MYSM1
| 1
MYSM1 binds c-MET promoter region. 1 / 1
| 1
reach
"In context with our finding that MYSM1 bound to the c-MET promoter region in close vicinity to PAX3 in melanoma cells, our data indicate that MYSM1 is an epigenetic regulator of melanoma growth and potentially promising new target for tumor therapy."
28978033
Bis(2-chloroethyl) sulfide decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
26392148
Bentiromide affects MYSM1
| 1
Bentiromide activates MYSM1. 1 / 1
| 1
reach
"Pifithrin α (PFT α) and Compound C, antagonists of p53 and AMPK, respectively, repressed ATP production and reversed the antidepressant effect of Mysm1 knockdown."
36414403
Acetylsalicylic acid decreases the amount of MYSM1. 1 / 1
| 1
reach
"Aspirin administration, reduced the protein expression of Mysm1, increased the protein expression of H2AK119-Ub and thereby reduced the Set7 protein expression in glomeruli isolated from diabetic animals and prevented renal fibrosis."
29656179
Abrine affects MYSM1
1 |
Abrine increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
31054353
XIAP affects RIPK2
| 1
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
WDR77 affects MYSM1
1 |
MYSM1 binds WDR77. 1 / 1
1 |
biogrid
No evidence text available
17707232
USP22 affects TMPRSS11D
| 1
USP22 binds TMPRSS11D and MYSM1. 1 / 1
| 1
sparser
"The finding that two DUBs, 2A-DUB and USP22 associate with HATs suggests an important functional interplay between these classes of enzymes."
18430235
UBC affects MYSM1
1 |
UBC binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
17707232
TUBB1 affects MYSM1
1 |
TUBB1 binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
17707232
TRF2 affects MYSM1
| 1
MYSM1 binds TRF2. 1 / 1
| 1
sparser
"TRF2 associates with telomeric DNA via a myb-like DNA binding domain."
19854131
TP63 affects MYSM1
| 1
TP63 increases the amount of MYSM1. 1 / 1
| 1
reach
"Alternatively, Mysm1 may influence p63 transcription by counteracting chromatin changes induced by PRC1 component Bmi1 -- with context dependent activatory or inhibitory influence in stem cells [XREF_BIBR], [and unpublished meeting communications]."
29495602
TP53 affects CDKN1A
| 1
TP53 binds CDKN1A, BBC3, and MYSM1. 1 / 1
| 1
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 /PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a /p21."
26768662
TP53 affects ARF
| 1
TP53 binds MYSM1 and ARF. 1 / 1
| 1
sparser
"In line with a previous report on Mysm1-binding to thep19 ARF -promoter in thymocytes [ xref ], an upstream regulator of TS p53, in Mysm1 −/− epidermal cells as well, mRNA expression ofp19 ARF was moderately increased along with increases in p53 levels and in apoptosis."
29495602
TNFAIP3 affects RNF31
| 1
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
TMPRSS11D affects USP22
| 1
USP22 binds TMPRSS11D and MYSM1. 1 / 1
| 1
sparser
"The finding that two DUBs, 2A-DUB and USP22 associate with HATs suggests an important functional interplay between these classes of enzymes."
18430235
TERF1 affects MYSM1
| 1
TERF1 binds MYSM1. 1 / 1
| 1
sparser
"Gel retardation analysis with a series of mutated telomere probes revealed that the internal GGGTTT sequence in the two-telomere repeats is critical for binding of Myb-like domain of RTBP1, which is consistent with the model of the TRF1."
10811811
TCEA1 affects MYSM1
| 1
TCEA1 binds MED25, MYSM1, and DREB2A. 1 / 1
| 1
sparser
"MED25 physically interacts with abiotic-stress associated TFs, DREB2A, ZFHD1, and MYB-Like ( xref ;Table xref )."
28659948
TACSTD2 affects MYSM1
| 1
TACSTD2 binds MYSM1. 1 / 1
| 1
sparser
"TACSTD2-MYSM1, LRP1B, and ASAP1-ADCY8 showed suggestive associations with serum Fe element levels (p < 5 × 10 -6 )."
34417961
TAB3 affects TAB2
| 1
RNF31 binds TAB2, MYSM1, and TAB3. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
SWIRM domain affects MYSM1
| 1
MYSM1 binds AR and SWIRM domain. 1 / 1
| 1
reach
"As 2A-DUB may interact with AR via its SWIRM domain (Metzger et al., 2005), recruitment of the complex might be AR dependent."
17707232
STK38 affects MYSM1
1 |
STK38 binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
17707232
STING1 affects K63
| 1
STING1 binds MYSM1 and K63. 1 / 1
| 1
reach
"MYSM1 subsequently interacts with STING and cleaves STING K63 linked ubiquitination to suppress cGAS STING signaling."
33086059
STAT5 affects Runx1
| 1
STAT5 binds IKZF1, MYSM1, Runx1, and PU.1. 1 / 1
| 1
sparser
"A weak association of endogenous MYSM1 protein and endogenous E2A (E47) protein was detected in WT BM Lin - progenitor cells, although the association of MYSM1 and PU.1, Ikaros, Stat5, or Runx1 was not positively identified (data not shown)."
22169041
RPL10 affects MYSM1
| 1
MYSM1 binds RPL10. 1 / 1
| 1
sparser
"Furthermore, upon relocalization, RPL10 interacts with the MYB-like protein L10-interacting myb domain-containing protein (LIMYB) to suppress the expression of translational machinery genes, which results in enhanced tolerance to begomovirus infection [ xref ]."
30403659
RNF31 affects TNFAIP3
| 1
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
RNF31 affects TAB3
| 1
RNF31 binds TAB2, MYSM1, and TAB3. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
RNF31 affects OTULIN
| 1
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
RNF2 affects PRC1
| 1
RNF2 binds BMI1, MYSM1, and PRC1. 1 / 1
| 1
sparser
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
RIPK2 affects XIAP
| 1
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
RFC5 affects PCNA
| 1
MYSM1 binds HELLS, PCNA, and RFC5. 1 / 1
| 1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
32466590
RB1 affects MYSM1
| 1
MYSM1 binds RB1. 1 / 1
| 1
sparser
"Moreover, we observed that MYSM1 transcription was strongly associated with the expression of tumor suppressor RB1 in PCa patients ( xref )."
31761786
RAP1 affects DNA-Binding Domain
| 1
sparser
"For this orientation of the recognition sequence, Rap1 binds with the N-terminal Myb-like region of its DNA-binding domain (DBD) facing the incoming polymerase and with the majority of the Rap1 contacts with the phosphate backbone of the DNA occurring on the non-template strand ( xref – xref )."
27001517
PU.1 affects STAT5
| 1
STAT5 binds IKZF1, MYSM1, Runx1, and PU.1. 1 / 1
| 1
sparser
"A weak association of endogenous MYSM1 protein and endogenous E2A (E47) protein was detected in WT BM Lin - progenitor cells, although the association of MYSM1 and PU.1, Ikaros, Stat5, or Runx1 was not positively identified (data not shown)."
22169041
PRMT5 affects MYSM1
1 |
PRMT5 binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
17707232
PRC1 affects RNF2
| 1
RNF2 binds BMI1, MYSM1, and PRC1. 1 / 1
| 1
sparser
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
POLD1 affects MYSM1
| 1
MYSM1 binds MSH6 and POLD1. 1 / 1
| 1
sparser
"Furthermore, mild interactions of MYSM1 with POLD1 and MSH6 and with Lamin B1, involved in higher-order chromatin structure and anchoring of chromatin, were detectable."
32466590
PHLPP1 affects MYSM1
| 1
PHLPP1 binds MYSM1. 1 / 1
| 1
sparser
"The qRT-PCR analyses showed that siRNA-mediated downregulation of MYSM1 resulted in a significant decrease in PHLPP1 expression, confirming the association of MYSM1 with PHLPP1 ( xref )."
31761786
PCNA affects RFC5
| 1
MYSM1 binds HELLS, PCNA, and RFC5. 1 / 1
| 1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
32466590
PAC affects MYSM1
| 1
MYSM1 binds PAC and HTH. 1 / 1
| 1
sparser
"An unexpectedly potent size regulator that emerged from our screens was Dot6, a Myb-like HTH transcription factor that binds to the PAC (Polymerase A and C) motif [ xref ]."
30921326
P6.9 affects MYSM1
| 1
MYSM1 binds P6.9. 1 / 1
| 1
sparser
"Telomeric DNA is assembled into a non nucleosomal structure, whose main component is Rap1p, a duplex, sequence specific DNA binding protein that binds telomeric DNA with its Myb-like binding domain an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19007917
OTULIN affects TNFAIP3
| 1
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
O41964 affects MYSM1
1 |
MYSM1 binds O41964. 1 / 1
1 |
virhostnet
No evidence text available
22028648
NOD2 affects XIAP
| 1
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
NFIL3 affects MYSM1
| 1
MYSM1 binds NFIL3. 1 / 1
| 1
reach
"In natural killer cell development, E4BP4 and NFIL3 interacts with the histone ubiquitinase MYSM1 and maintains an active chromatin state at the Id2 locus [XREF_BIBR]."
29095827
Mice affects MYSM1
| 1
Mice activates MYSM1. 1 / 1
| 1
reach
"The recipient mice were treated either with tamoxifen to induce Mysm1‐deletion or with vehicle corn oil."
34114734
MYSM1 affects ubiquitination
| 1
MYSM1 inhibits ubiquitination. 1 / 1
| 1
sparser
"The deubiquitinases OTUB1/2 [ xref , xref ], UCHL1 [ xref ], MYSM1 [ xref ] and DUBA [ xref ] inhibit K63-linked ubiquitination of TRAF3 or TRAF6 and negatively regulate IFNs production during viral infection."
29734366
MYSM1 affects ubH2A
| 1
MYSM1 deubiquitinates ubH2A. 1 / 1
| 1
reach
"Collectively, these data indicate that MYSM1 not only deubiquitinates ubH2A, but also orchestrates histone modifications at the Ebf1 locus and that its deficiency results in the repressive histone modifications and impaired recruitment of the key transcription factors to the Ebf1 locus."
22169041
MYSM1 affects translation
| 1
MYSM1 activates translation. 1 / 1
| 1
reach
"Overall, we demonstrate that the loss of MYSM1 in mouse B cell lymphoma represses the induction of ribosomal protein genes, reduces cellular protein synthesis rate, promotes p53 activation and potently inhibits cMYC oncogenic functions.To compare the location of the genomic binding sites of MYSM1 and cMYC, we consolidated the ChIP‐Seq datasets for cMYC and its dimerization partner MAX from multipotent haematopoietic progenitor cells HPC7 12 , 13 with the MYSM1 ChIP‐Seq acquired in our recent work in a B cell progenitor cell line Ba/F3."
34114734
MYSM1 affects transferase
| 1
MYSM1 binds transferase. 1 / 1
| 1
sparser
"2A-DUB is associated with the p/CAF histone acetyl transferase."
18430235
MYSM1 affects tissue function
| 1
MYSM1 activates tissue function. 1 / 1
| 1
eidos
"MYSM1 restricts the Rb and p53 pathways in senescent cells and mouse tissues , improves tissue function , and reduces the accumulation of aged cells ."
33240758
MYSM1 affects thrb
| 1
MYSM1 binds thrb. 1 / 1
| 1
sparser
"TRB proteins bind specifically telomeric double strand DNA through their myb-like domain of a telobox type [ xref , xref ], as well as the human core components of shelterin—TRF1 and TRF2 proteins."
30654521
MYSM1 affects str
| 1
MYSM1 binds str. 1 / 1
| 1
sparser
"CrBPF1 was identified as a MYB-like protein that binds the BA region of the C. roseus STR promoter ( xref )."
26483828
MYSM1 affects senescence cell accumulation mice tissues
| 1
MYSM1 inhibits senescence cell accumulation mice tissues. 1 / 1
| 1
eidos
"These findings indicated that loss of MYSM1 promotes senescence cell accumulation in mice tissues ."
33240758
MYSM1 affects ribosomal protein genes
| 1
MYSM1 inhibits ribosomal protein genes. 1 / 1
| 1
reach
"Overall, we demonstrate that the loss of MYSM1 in mouse B cell lymphoma represses the induction of ribosomal protein genes, reduces cellular protein synthesis rate, promotes p53 activation and potently inhibits cMYC oncogenic functions.To compare the location of the genomic binding sites of MYSM1 and cMYC, we consolidated the ChIP‐Seq datasets for cMYC and its dimerization partner MAX from multipotent haematopoietic progenitor cells HPC7 12 , 13 with the MYSM1 ChIP‐Seq acquired in our recent work in a B cell progenitor cell line Ba/F3."
34114734
MYSM1 inhibits response to stress. 1 / 1
| 1
reach
"53 Our work shows that MYSM1 represses p53 stress response genes by antagonizing other histone modifications (H3K27ac and H3K4me3)."
26768662
MYSM1 affects recruitment
| 1
MYSM1 activates recruitment. 1 / 1
| 1
eidos
"It is also unclear whether the binding of MYSM1 to the transcription factors is needed for their enhanced recruitment to specific MYSM1-regulated genes , or whether MYSM1 enhances their recruitment indirectly through chromatin opening and remodeling ."
32344625
MYSM1 affects recruitment hematopoietic transcription PU.1
| 1
MYSM1 activates recruitment hematopoietic transcription PU.1. 1 / 1
| 1
eidos
"MYSM1 bound to the Flt3 gene promoter , and loss of MYSM1 resulted in reduced recruitment of the major hematopoietic transcription factor PU.1 and an increase in repressive histone marks H2AK119ub and H3K27me3 at the Flt3 locus [ 33 ] ( Figure 2 ) ."
32344625
MYSM1 affects recruitment PRC1 complex proteins RING1B
| 1
MYSM1 inhibits recruitment PRC1 complex proteins RING1B. 1 / 1
| 1
eidos
"MYSM1 was required for normal recruitment of transcription factors GATA2 and RUNX1 to the Gfi1 locus , while loss of MYSM1 resulted in increased recruitment of the PRC1 complex proteins RING1B and BMI1 and increased levels of histone H2AK119ub [ 34 ] ( Figure 2 ) ."
32344625
MYSM1 affects recruitment E4BP4 Id2 locus
| 1
MYSM1 inhibits recruitment E4BP4 Id2 locus. 1 / 1
| 1
eidos
"In support of the role of ID2 in NK cell maturation , deficiency of MYSM1 , which mediates the recruitment of E4BP4 to the Id2 locus , leads to defects in NK cell maturation , but not NK lineage specification or commitment ( 23 ) ."
32849653
MYSM1 affects progress aging
| 1
MYSM1 inhibits progress aging. 1 / 1
| 1
eidos
"MYSM1 represses the processes of senescence and the progress of aging , prevents the damage to vital organs , and reduces the development of aging-associated diseases , which lead to the prolongation of lifespan ."
33240758
MYSM1 affects processes senescence
| 1
MYSM1 inhibits processes senescence. 1 / 1
| 1
eidos
"MYSM1 represses the processes of senescence and the progress of aging , prevents the damage to vital organs , and reduces the development of aging-associated diseases , which lead to the prolongation of lifespan ."
33240758
MYSM1 affects potential primary osteoblasts differentiate mature osteoblasts
| 1
MYSM1 activates potential primary osteoblasts differentiate mature osteoblasts. 1 / 1
| 1
eidos
"Recently , study demonstrates that MYSM1 deficiency impairs the potential for primary osteoblasts to differentiate into mature osteoblasts ."
30123285
MYSM1 affects polyubiquitin chains
| 1
MYSM1 activates polyubiquitin chains. 1 / 1
| 1
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
eidos
"Altogether , MYSM1 was proposed to inhibit plasma cell differentiation by maintaining Pax5 expression , via histone H2AK119-deubiquitination and recruitment of transcription factor PU.1 to the Pax5 locus [ 30 ] ( Figure 2 ) ."
32344625
MYSM1 affects pS2-Pol II
| 1
MYSM1 inhibits pS2-Pol II. 1 / 1
| 1
reach
"More importantly, both pS2-Pol II and H3K36M3 were remarkably diminished by siRNA of 2A-DUB even in the presence of DHT, mainly on the exon 4 region."
17707232
MYSM1 affects p53-target gene promoters
| 1
MYSM1 binds p53-target gene promoters. 1 / 1
| 1
reach
"The recruitment of MYSM1 to p53-target gene promoters was tested using chromatin immunoprecipitation (ChIP) in a Ba/F3 hematopoietic progenitor cell line stably expressing FLAG-MYSM1 (XREF_SUPPLEMENTARY)."
26768662
MYSM1 affects p53-activation
| 1
MYSM1 inhibits p53-activation. 1 / 1
| 1
eidos
"This was also observed after an inducible deletion of Mysm1 in adult mice , indicating that MYSM1 is required constitutively to repress p53-activation [ 46 ] ."
32344625
MYSM1 affects p53 pathways
| 1
MYSM1 inhibits p53 pathways. 1 / 1
| 1
eidos
"MYSM1 restricts the Rb and p53 pathways in senescent cells and mouse tissues , improves tissue function , and reduces the accumulation of aged cells ."
33240758
MYSM1 affects organs
| 1
MYSM1 inhibits organs. 1 / 1
| 1
eidos
"MYSM1 represses the processes of senescence and the progress of aging , prevents the damage to vital organs , and reduces the development of aging-associated diseases , which lead to the prolongation of lifespan ."
33240758
MYSM1 affects oncogenic cMYC B cell lymphoma
| 1
MYSM1 activates oncogenic cMYC B cell lymphoma. 1 / 1
| 1
eidos
"Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma ."
34114734
MYSM1 affects nmoT
| 1
MYSM1 binds nmoT. 1 / 1
| 1
sparser
"The Myb-like protein is required for transposition and physically interacts with the N-terminal region of the transposase via its C-terminal domain."
18339812
MYSM1 affects nitric oxide
| 1
MYSM1 activates nitric oxide. 1 / 1
| 1
reach
"Furthermore, Mysm1 deficient cells transduced with lentivirus containing miR-150 mimics produced less pro inflammatory factors and more NO."
30895711
MYSM1 affects mouse tissues
| 1
MYSM1 inhibits mouse tissues. 1 / 1
| 1
eidos
"In addition , Mysm1 deficiency led to the induction of SASP in mouse tissues ."
33240758
MYSM1 affects miR-200 family members
| 1
MYSM1 inhibits miR-200 family members. 1 / 1
| 1
reach
"MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling."
34706761
MYSM1 affects miR-150 transcription
| 1
MYSM1 activates miR-150 transcription. 1 / 1
| 1
eidos
"Mysm1 , a histone deubiquitinase , is induced by TNF-alpha and IFNgamma in ASCs and promotes miR-150 transcription , which enhances iNOS production ."
32363193
MYSM1 affects miR-150 gene
| 1
MYSM1 increases the amount of miR-150 gene. 1 / 1
| 1
reach
"As MYSM1 may recruit transcription factors to regulate the transcription of target genes, we tested whether MYSM1 stimulated transcription of the miR-150 gene."
27590507
MYSM1 affects mediated DNA repair
| 1
MYSM1 activates mediated DNA repair. 1 / 1
| 1
eidos
"MYSM1 promotes HR mediated DNA repair ."
33240758
MYSM1 affects human colorectal cancer tumorigenesis
| 1
MYSM1 inhibits human colorectal cancer tumorigenesis. 1 / 1
| 1
eidos
"MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members / CDH1 and blocking PI3K / AKT signaling ."
34706761
MYSM1 activates homeostatic process. 1 / 1
| 1
reach
"Strong IL-15 receptor stimulation by IL-2 pre-ligated to an anti-IL-2 antibody, or SOCS-3 deficiency, partially restores homeostasis in Id2 deficient NK cells.In support of the role of ID2 in NK cell maturation, deficiency of MYSM1, which mediates the recruitment of E4BP4 to the Id2 locus, leads to defects in NK cell maturation, but not NK lineage specification or commitment (23)."
32849653
MYSM1 affects gene expression
| 1
reach
"9 One of the main known MYSM1 substrates is histone H2A, monoubiquitinated at K119, and MYSM1 catalytic activity on this epigenetic mark promotes the activation of gene expression."
34114734
MYSM1 affects etoposide
| 1
MYSM1 activates etoposide. 1 / 1
| 1
reach
"Nuclear MYSM1 intensity increased as early as 0.5 h post etoposide exposure of KG-1a cells, and stayed elevated for 1–3 h in parallel with increases in γH2AX cells as indicated in the quantifications (Figure 1D)."
32466590
MYSM1 inhibits epithelial to mesenchymal transition. 1 / 1
| 1
reach
"Furthermore, silencing MYSM1 stimulated PI3K/AKT signaling and promoted EMT in CRC cells."
34706761
MYSM1 affects enrichment H2AK119ub1 modification
| 1
MYSM1 inhibits enrichment H2AK119ub1 modification. 1 / 1
| 1
eidos
"Mechanistically , MYSM1 directly bound to the promoter region of miR-200 / CDH1 , impaired the enrichment of repressive H2AK119ub1 modification and epigenetically enhanced miR-200 / CDH1 expression ."
34706761
MYSM1 affects dioxygen
| 1
MYSM1 activates dioxygen. 1 / 1
| 1
reach
"The Mysm1 -/- thymocytes also produced enhanced levels of reactive oxygen species (ROS), but reduced the mitochondrial membrane potential (XREF_FIG)."
27277682
MYSM1 affects development aging-associated diseases
| 1
MYSM1 inhibits development aging-associated diseases. 1 / 1
| 1
eidos
"MYSM1 represses the processes of senescence and the progress of aging , prevents the damage to vital organs , and reduces the development of aging-associated diseases , which lead to the prolongation of lifespan ."
33240758
MYSM1 affects defects
| 1
MYSM1 inhibits defects. 1 / 1
| 1
eidos
"Several studies have found that MYSM1 deficiency or mutation can lead to defects during the development and function of HSCs , B cells , natural killer ( NK ) cells and dendritic cells , and it also results in the development of lymphopenia , anemia , and thrombocytopenia , and low B-cell and NK-cell counts in both mice and humans [ 45,51,52,53,54,55 ] ."
32354135
MYSM1 affects defects NK cell maturation
| 1
MYSM1 inhibits defects NK cell maturation. 1 / 1
| 1
eidos
"In support of the role of ID2 in NK cell maturation , deficiency of MYSM1 , which mediates the recruitment of E4BP4 to the Id2 locus , leads to defects in NK cell maturation , but not NK lineage specification or commitment ( 23 ) ."
32849653
MYSM1 activates decreased bone mass. 1 / 1
| 1
eidos
"MYSM1 deficiency leads to decreased bone mass ."
30123285
MYSM1 affects colony
| 1
MYSM1 activates colony. 1 / 1
| 1
eidos
"These findings indicated that MYSM1 promotes cell proliferation and colony formation and attenuates SA-beta-Gal activation to repress senescence ."
33240758
MYSM1 affects cell death
| 1
MYSM1 activates cell death. 1 / 1
| 1
reach
"To gain insight into the functional defects in Mysm1 -/- Puma -/- MPP4s contributing to cell death and downstream lymphopoiesis failures, we performed RNA sequencing (RNA-Seq) of MPPs (Lin - cKit + Sca1 + CD150 -) from Mysm1 -/- Puma -/-, Mysm1 -/- Puma +/-, Puma -/-, and wild-type mice (Mysm1 -/- Puma +/- phenocopies Mysm1 -/-)."
26768662
MYSM1 affects cMYC oncogenic
| 1
MYSM1 activates cMYC oncogenic. 1 / 1
| 1
eidos
"Importantly , the loss of MYSM1 also strongly inhibits cMYC oncogenic activity and protects against B cell lymphoma onset and progression in the mouse models ."
34114734
MYSM1 affects c-MET promoter
| 1
MYSM1 binds c-MET promoter. 1 / 1
| 1
reach
"In support of a collaboration of MYSM1 with PAX3 in transcriptional regulation, MYSM1 binding to the c-MET promoter in melanoma cells occurred in vicinity to the PAX3 consensus sequence previously described [XREF_BIBR]."
28978033
MYSM1 affects c-MET promoter region
| 1
MYSM1 binds c-MET promoter region. 1 / 1
| 1
reach
"In context with our finding that MYSM1 bound to the c-MET promoter region in close vicinity to PAX3 in melanoma cells, our data indicate that MYSM1 is an epigenetic regulator of melanoma growth and potentially promising new target for tumor therapy."
28978033
MYSM1 affects c-MET promoter region
| 1
MYSM1 binds c-MET promoter region. 1 / 1
| 1
reach
"In context with our finding that MYSM1 bound to the c-MET promoter region in close vicinity to PAX3 in melanoma cells, our data indicate that MYSM1 is an epigenetic regulator of melanoma growth and potentially promising new target for tumor therapy."
28978033
MYSM1 affects binding PRC1 complex proteins
| 1
MYSM1 inhibits binding PRC1 complex proteins. 1 / 1
| 1
eidos
"At many of these loci , loss of MYSM1 resulted in increased binding of PRC1 complex proteins and elevated levels of histone H2AK119ub [ 20,30,32,33,34 ] , suggesting that MYSM1 antagonizes PRC1-mediated histone ubiquitination and transcriptional repression ."
32344625
MYSM1 affects aging-related pathologies
| 1
MYSM1 inhibits aging-related pathologies. 1 / 1
| 1
eidos
"Together , the findings demonstrated that Mysm1 deficiency promotes aging-related pathologies , facilitates developmental defects and early death , thereby shortening the lifespan of mice ."
33240758
MYSM1 affects aging aging-related pathologies
| 1
MYSM1 inhibits aging aging-related pathologies. 1 / 1
| 1
eidos
"Mysm1 deficiency promotes aging and aging-related pathologies and reduces lifespan in mice ."
33240758
MYSM1 affects activation
| 1
MYSM1 inhibits activation. 1 / 1
| 1
sparser
"MYSM1 interacts with AR and inhibits activation of Akt/c-Raf/GSK-3β signaling in prostate cancer."
31761786
MYSM1 affects activation p53 stress response
| 1
MYSM1 inhibits activation p53 stress response. 1 / 1
| 1
eidos
"] Loss of Mysm1 has been shown to promote activation of the p53 stress response and induced abnormal cell development and tissue differentiation ."
33240758
MYSM1 affects accumulation aged cells
| 1
MYSM1 inhibits accumulation aged cells. 1 / 1
| 1
eidos
"MYSM1 restricts the Rb and p53 pathways in senescent cells and mouse tissues , improves tissue function , and reduces the accumulation of aged cells ."
33240758
MYSM1 affects XIAP
| 1
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
MYSM1 affects XBP1
| 1
MYSM1 activates XBP1. 1 / 1
| 1
reach
"Furthermore, Mysm1 -/- plasma cells showed enhanced levels of antibody secretion in vitro and had altered gene expression profiles with downregulation of B cell lineage transcription factors Pax5 and Bach2, and increased expression of plasma cell transcription factors Blimp1 and Xbp1 [XREF_BIBR]."
32344625
MYSM1 affects WDR77
1 |
MYSM1 binds WDR77. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects USP22
| 1
USP22 binds TMPRSS11D and MYSM1. 1 / 1
| 1
sparser
"The finding that two DUBs, 2A-DUB and USP22 associate with HATs suggests an important functional interplay between these classes of enzymes."
18430235
MYSM1 affects UBC
1 |
UBC binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects TUBB1
1 |
TUBB1 binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects TRF2
| 1
MYSM1 binds TRF2. 1 / 1
| 1
sparser
"TRF2 associates with telomeric DNA via a myb-like DNA binding domain."
19854131
MYSM1 affects TNFAIP3
| 1
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
MYSM1 affects TMPRSS11D, and USP22
| 1
USP22 binds TMPRSS11D and MYSM1. 1 / 1
| 1
sparser
"The finding that two DUBs, 2A-DUB and USP22 associate with HATs suggests an important functional interplay between these classes of enzymes."
18430235
MYSM1 affects THR
| 1
MYSM1 increases the amount of THR. 1 / 1
| 1
reach
"In contrast, RARbeta2, a known target gene of retinoic acid receptor alpha (RARalpha), was not detectably regulated by 2A-DUB, and thyroid hormone receptor (T 3 R)-mediated transcription was repressed[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
MYSM1 affects TEWL
| 1
MYSM1 activates TEWL. 1 / 1
| 1
reach
"Mysm1 deficient mice had significantly increased TEWL compared with their wild-type littermates (XREF_FIG B); reflecting potential changes in epidermal barrier formation at this age group."
29495602
MYSM1 affects TERF1
| 1
TERF1 binds MYSM1. 1 / 1
| 1
sparser
"Gel retardation analysis with a series of mutated telomere probes revealed that the internal GGGTTT sequence in the two-telomere repeats is critical for binding of Myb-like domain of RTBP1, which is consistent with the model of the TRF1."
10811811
MYSM1 affects TCEA1
| 1
TCEA1 binds MED25, MYSM1, and DREB2A. 1 / 1
| 1
sparser
"MED25 physically interacts with abiotic-stress associated TFs, DREB2A, ZFHD1, and MYB-Like ( xref ;Table xref )."
28659948
MYSM1 affects TACSTD2
| 1
TACSTD2 binds MYSM1. 1 / 1
| 1
sparser
"TACSTD2-MYSM1, LRP1B, and ASAP1-ADCY8 showed suggestive associations with serum Fe element levels (p < 5 × 10 -6 )."
34417961
MYSM1 affects TAB3
| 1
RNF31 binds TAB2, MYSM1, and TAB3. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
MYSM1 affects SWIRM domain
| 1
MYSM1 binds AR and SWIRM domain. 1 / 1
| 1
reach
"As 2A-DUB may interact with AR via its SWIRM domain (Metzger et al., 2005), recruitment of the complex might be AR dependent."
17707232
MYSM1 affects STK38
1 |
STK38 binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects STAT5
| 1
STAT5 binds IKZF1, MYSM1, Runx1, and PU.1. 1 / 1
| 1
sparser
"A weak association of endogenous MYSM1 protein and endogenous E2A (E47) protein was detected in WT BM Lin - progenitor cells, although the association of MYSM1 and PU.1, Ikaros, Stat5, or Runx1 was not positively identified (data not shown)."
22169041
MYSM1 affects RUNX1
| 1
MYSM1 activates RUNX1. 1 / 1
| 1
reach
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
MYSM1 affects RPL10
| 1
MYSM1 binds RPL10. 1 / 1
| 1
sparser
"Furthermore, upon relocalization, RPL10 interacts with the MYB-like protein L10-interacting myb domain-containing protein (LIMYB) to suppress the expression of translational machinery genes, which results in enhanced tolerance to begomovirus infection [ xref ]."
30403659
MYSM1 affects RNF31, TAB2, and TAB3
| 1
RNF31 binds TAB2, MYSM1, and TAB3. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
MYSM1 affects RFC5
| 1
MYSM1 binds HELLS, PCNA, and RFC5. 1 / 1
| 1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
32466590
MYSM1 affects RB1
| 1
MYSM1 binds RB1. 1 / 1
| 1
sparser
"Moreover, we observed that MYSM1 transcription was strongly associated with the expression of tumor suppressor RB1 in PCa patients ( xref )."
31761786
MYSM1 affects PRMT5
1 |
PRMT5 binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects PRDM1
| 1
MYSM1 activates PRDM1. 1 / 1
| 1
reach
"Furthermore, Mysm1 -/- plasma cells showed enhanced levels of antibody secretion in vitro and had altered gene expression profiles with downregulation of B cell lineage transcription factors Pax5 and Bach2, and increased expression of plasma cell transcription factors Blimp1 and Xbp1 [XREF_BIBR]."
32344625
MYSM1 affects PRC1_complex
| 1
MYSM1 inhibits PRC1_complex. 1 / 1
| 1
reach
"The authors concluded that MYSM1 antagonizes the action of the polycomb repressive complex 1 (PRC1) on the Ebf1 promoter, enabling lineage specific transcription factors, such as E2A, to be recruited to the Ebf1 locus and to induce its transcription [XREF_BIBR]."
22997486
MYSM1 affects PRC1
| 1
RNF2 binds BMI1, MYSM1, and PRC1. 1 / 1
| 1
sparser
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
MYSM1 affects POLD1
| 1
MYSM1 binds MSH6 and POLD1. 1 / 1
| 1
sparser
"Furthermore, mild interactions of MYSM1 with POLD1 and MSH6 and with Lamin B1, involved in higher-order chromatin structure and anchoring of chromatin, were detectable."
32466590
MYSM1 affects PHLPP1
| 1
PHLPP1 binds MYSM1. 1 / 1
| 1
sparser
"The qRT-PCR analyses showed that siRNA-mediated downregulation of MYSM1 resulted in a significant decrease in PHLPP1 expression, confirming the association of MYSM1 with PHLPP1 ( xref )."
31761786
MYSM1 affects PCNA
| 1
MYSM1 binds HELLS, PCNA, and RFC5. 1 / 1
| 1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
32466590
MYSM1 affects PAC
| 1
MYSM1 binds PAC and HTH. 1 / 1
| 1
sparser
"An unexpectedly potent size regulator that emerged from our screens was Dot6, a Myb-like HTH transcription factor that binds to the PAC (Polymerase A and C) motif [ xref ]."
30921326
MYSM1 affects P6.9
| 1
MYSM1 binds P6.9. 1 / 1
| 1
sparser
"Telomeric DNA is assembled into a non nucleosomal structure, whose main component is Rap1p, a duplex, sequence specific DNA binding protein that binds telomeric DNA with its Myb-like binding domain an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19007917
MYSM1 affects OTULIN
| 1
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
MYSM1 affects O41964
1 |
MYSM1 binds O41964. 1 / 1
1 |
virhostnet
No evidence text available
22028648
MYSM1 inhibits Neoplasm Metastasis. 1 / 1
| 1
reach
"Therefore, we hypothesized that MYSM-1 may suppress the metastasis of renal cell carcinoma in light of paucity of data regarding MYSM-1 in the cancers."
26409454
MYSM1 affects NOS2
| 1
MYSM1 activates NOS2. 1 / 1
| 1
reach
"Mysm1, a histone deubiquitinase, is induced by TNF-alpha and IFNgamma in ASCs and promotes miR-150 transcription, which enhances iNOS production."
32363193
MYSM1 affects NOD2, RIPK2, and XIAP
| 1
RIPK2 binds MYSM1, NOD2, and XIAP. 1 / 1
| 1
sparser
"Although MYSM1 interacted with NOD2, RIP2, and XIAP, consistent with the above data (Fig.  xref ), we observed no direct interaction between MYSM1 and HOIP, TAK1, TAB2, TAB3, or the IKK complex (Fig. xref )."
30405132
MYSM1 affects NK lineage specification
| 1
MYSM1 inhibits NK lineage specification. 1 / 1
| 1
eidos
"In support of the role of ID2 in NK cell maturation , deficiency of MYSM1 , which mediates the recruitment of E4BP4 to the Id2 locus , leads to defects in NK cell maturation , but not NK lineage specification or commitment ( 23 ) ."
32849653
MYSM1 affects NFIL3
| 1
MYSM1 binds NFIL3. 1 / 1
| 1
reach
"In natural killer cell development, E4BP4 and NFIL3 interacts with the histone ubiquitinase MYSM1 and maintains an active chromatin state at the Id2 locus [XREF_BIBR]."
29095827
MYSM1 affects Mice
| 1
MYSM1 inhibits Mice. 1 / 1
| 1
reach
"Increased MYSM1 can decrease type I IFN, IL-6, and other inflammatory cytokines in SLE mice (86)."
35603197
MYSM1 affects Mice Lifespan MYSM1
| 1
MYSM1 activates Mice Lifespan MYSM1. 1 / 1
| 1
eidos
"MYSM1 Deficiency Reduces Mice Lifespan MYSM1 is a key regulator of tissue differentiation and development ."
33240758
reach
"The Mysm1 -/- thymocytes also produced enhanced levels of reactive oxygen species (ROS), but reduced the mitochondrial membrane potential (XREF_FIG)."
27277682
MYSM1 affects Mcl-1 mRNA
| 1
MYSM1 decreases the amount of Mcl-1 mRNA. 1 / 1
| 1
reach
"Among other survival genes differentially expressed in Mysm1 -/- and wild-type hematopoiesis, Mcl-1 mRNA levels were significantly decreased by factor 3 in Mysm1 -/- BM (XREF_FIG), whereas decreases in Bcl-X L mRNA were detectable to the same extent in Mysm1 -/- thymi (XREF_FIG)."
25613381
MYSM1 affects MYB
| 1
MYSM1 binds MYB and HTH. 1 / 1
| 1
sparser
"Both genes contained two introns, encoded 257 amino acids with two-Aa difference, and carried the unabridged HTH-MYB, MYB-like DNA-binding, and SANT domains."
31035916
MYSM1 affects MSH6
| 1
MYSM1 binds MSH6 and POLD1. 1 / 1
| 1
sparser
"Furthermore, mild interactions of MYSM1 with POLD1 and MSH6 and with Lamin B1, involved in higher-order chromatin structure and anchoring of chromatin, were detectable."
32466590
MYSM1 affects MEK
| 1
MYSM1 inhibits MEK. 1 / 1
| 1
reach
"Significant reduction of MYSM1 protein expression was detectable upon treatment of A375 cells with either inhibitor PD128,345, targeting mitogen activated protein kinase kinase MEK, alone or in combination with an Akt1/2-inhibitor for 24 hrs."
28978033
MYSM1 affects MED25
| 1
TCEA1 binds MED25, MYSM1, and DREB2A. 1 / 1
| 1
sparser
"MED25 physically interacts with abiotic-stress associated TFs, DREB2A, ZFHD1, and MYB-Like ( xref ;Table xref )."
28659948
MYSM1 affects MAPK
| 1
MYSM1 inhibits MAPK. 1 / 1
| 1
reach
"Significant reduction of MYSM1 protein expression was detectable upon treatment of A375 cells with either inhibitor PD128,345, targeting mitogen activated protein kinase kinase MEK, alone or in combination with an Akt1/2-inhibitor for 24 hrs."
28978033
MYSM1 affects Lymphoma, B-Cell
| 1
reach
"Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma."
34114734
MYSM1 affects Leu-Lys
| 1
MYSM1 inhibits Leu-Lys. 1 / 1
| 1
reach
"We found that MYSM1 deficiency significantly reduced the proportion of LSK cells and LK cells in the G 0 phase, whereas there was a significant increase in the proportion of LSK cells and LK cells in G 1 phase (XREF_FIG)."
29694335
MYSM1 affects LSK
| 1
MYSM1 inhibits LSK. 1 / 1
| 1
reach
"We found that MYSM1 deficiency significantly reduced the proportion of LSK cells and LK cells in the G 0 phase, whereas there was a significant increase in the proportion of LSK cells and LK cells in G 1 phase (XREF_FIG)."
29694335
MYSM1 affects KIF11
1 |
MYSM1 binds KIF11. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects K63
| 1
STING1 binds MYSM1 and K63. 1 / 1
| 1
reach
"MYSM1 subsequently interacts with STING and cleaves STING K63 linked ubiquitination to suppress cGAS STING signaling."
33086059
MYSM1 affects Interferon
| 1
MYSM1 inhibits Interferon. 1 / 1
| 1
reach
"Increased MYSM1 can decrease type I IFN, IL-6, and other inflammatory cytokines in SLE mice (86)."
35603197
MYSM1 affects IgM
| 1
MYSM1 activates IgM. 1 / 1
| 1
reach
"This suggests that miR-150 is involved in IgM enhancement induced by MYSM1 deficiency."
27590507
MYSM1 affects IRF4
| 1
MYSM1 binds IRF4. 1 / 1
| 1
sparser
"However, the association of MYSM1 with IRF4 ( xref ), Stat3/5, NF-kB, and AP-1 at the Pax5 locus in naïve WT B cells was not positively identified in our assays."
26348977
MYSM1 affects IL6
| 1
MYSM1 inhibits IL6. 1 / 1
| 1
reach
"Increased MYSM1 can decrease type I IFN, IL-6, and other inflammatory cytokines in SLE mice (86)."
35603197
MYSM1 affects IKZF1
| 1
STAT5 binds IKZF1, MYSM1, Runx1, and PU.1. 1 / 1
| 1
sparser
"A weak association of endogenous MYSM1 protein and endogenous E2A (E47) protein was detected in WT BM Lin - progenitor cells, although the association of MYSM1 and PU.1, Ikaros, Stat5, or Runx1 was not positively identified (data not shown)."
22169041
MYSM1 affects IKK_complex
| 1
sparser
"Remarkably, we found no direct interaction between MYSM1 and LUBAC or TAK1 or the IKK complex (NEMO, IKKα/β) (Figure  xref c.  xref and Fig.  xref )."
30405132
MYSM1 affects IFNs
| 1
MYSM1 inhibits IFNs. 1 / 1
| 1
reach
"Importantly, MYSM1 treatment represses the production of IFNs and pro inflammatory cytokines in the PBMCs of SLE patients."
33086059
MYSM1 affects IFN IL-6 inflammatory cytokines mice
| 1
MYSM1 inhibits IFN IL-6 inflammatory cytokines mice. 1 / 1
| 1
eidos
"Increased MYSM1 can decrease type I IFN , IL-6 , and other inflammatory cytokines in SLE mice ( 86 ) ."
35603197
MYSM1 affects Hypersensitivity
| 1
MYSM1 binds Hypersensitivity. 1 / 1
| 1
sparser
"IGS002 codes for a R2R3 Myb-like protein, which is associated with HR and programmed cell death (PCD) regulation in response to pathogen attack through induction of SA biosynthesis xref ."
21533105
MYSM1 affects Histone_H2A
| 1
MYSM1 deubiquitinates Histone_H2A. 1 / 1
| 1
reach
"MYSM1, a member of the JAMM family, is a histone DUB which specifically deubiquitinates histone 2A [129]."
30123285
MYSM1 affects HSPA1A
1 |
MYSM1 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects HNRNPH1
1 |
MYSM1 binds HNRNPH1. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects HATs
| 1
MYSM1 binds HATs. 1 / 1
| 1
reach
"The finding that two DUBs, 2A-DUB and USP22 associate with HATs suggests an important functional interplay between these classes of enzymes."
18430235
MYSM1 affects H3K36M3
| 1
MYSM1 inhibits H3K36M3. 1 / 1
| 1
reach
"More importantly, both pS2-Pol II and H3K36M3 were remarkably diminished by siRNA of 2A-DUB even in the presence of DHT, mainly on the exon 4 region."
17707232
MYSM1 affects H2AK119
| 1
MYSM1 deubiquitinates H2AK119. 1 / 1
| 1
reach
"To confirm that the observed up-regulation of lamin A/C was due to specific knockdown of Ring1 or Rnf2 rather than off-target effects, we overexpressed Mysm1, which deubiquitinates H2AK119 in opposition to Ring1 and Rnf2."
30072429
MYSM1 affects H2AC17
1 |
MYSM1 deubiquitinates H2AC17. 1 / 1
1 |
MYSM1 affects GFI1
| 1
MYSM1 binds GFI1. 1 / 1
| 1
sparser
"We found that Mysm1 directly associates with the Gfi1 enhancer element and promotes its transcription through Gata2 and Runx1 transactivation."
24014243
MYSM1 affects GATA2
| 1
MYSM1 activates GATA2. 1 / 1
| 1
reach
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
MYSM1 affects Efficiency
| 1
MYSM1 activates Efficiency. 1 / 1
| 1
eidos
"] In transfected HEK293T cells , Mysm1 promoted HR efficiency ( Figure 1M ) , but it had no effect on the efficiency of NHEJ ( Figure 1N ) ."
33240758
MYSM1 affects Ebf1beta promoter
| 1
Modified MYSM1 activates Ebf1beta promoter. 1 / 1
| 1
reach
"MYSM1 expression activated transcription of the Ebf1alpha promoter and modestly activated the Ebf1beta promoter, but only marginally activated the Pax5 promoter and Cd79a promoter."
22169041
MYSM1 affects Ebf1alpha promoter
| 1
Modified MYSM1 increases the amount of Ebf1alpha promoter. 1 / 1
| 1
reach
"MYSM1 expression activated transcription of the Ebf1alpha promoter and modestly activated the Ebf1beta promoter, but only marginally activated the Pax5 promoter and Cd79a promoter."
22169041
MYSM1 affects EEF1A1
1 |
MYSM1 binds EEF1A1. 1 / 1
1 |
biogrid
No evidence text available
17707232
MYSM1 affects DPEP1
| 1
MYSM1 inhibits DPEP1. 1 / 1
| 1
reach
"118 Expression of MYSM1 decreases MDP stimulated NOD2 activation in cells, and in mouse models, knockout of MYSM1 leads to increased inflammation and liver damage, showing the DUB to be a critical negative regulator of NOD2 signaling."
30890292
sparser
"For this orientation of the recognition sequence, Rap1 binds with the N-terminal Myb-like region of its DNA-binding domain (DBD) facing the incoming polymerase and with the majority of the Rap1 contacts with the phosphate backbone of the DNA occurring on the non-template strand ( xref – xref )."
27001517
MYSM1 affects DNA damage-induced senescence
| 1
MYSM1 inhibits DNA damage-induced senescence. 1 / 1
| 1
eidos
"Higher numbers of TUNEL-positive cells were observed in the liver of AAV9-Ctrl-treated mice compared to AAV9-Mysm1-treated mice ( Figure S11A , Supporting Information ) , confirming that MYSM1 suppresses DNA damage-induced senescence and apoptosis ."
33240758
MYSM1 affects DNA Damage
| 1
MYSM1 inhibits DNA Damage. 1 / 1
| 1
reach
"Mechanistically, defective development of Mysm1-deficient mice correlated with altered gene transcription, increased apoptosis, and increased DNA damage in a variety of tissues, and was largely rescued by concomitant deletion of tumor suppressor p53 [38,42,43,44]."
32466590
MYSM1 affects DICER1
1 |
DICER1 binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
24778252
MYSM1 affects DHPS
| 1
DHPS binds MYSM1. 1 / 1
| 1
sparser
"At least one shelterin component, Rap1, is present in S. cerevisiae , although unlike vertebrate RAP1, ScRap1p directly binds ds telomeric DNA through two myb-like DNA binding domains and contributes to telomere length regulation and telomere silencing ( xref )."
19854131
MYSM1 affects DDR-Associated SASP
| 1
MYSM1 inhibits DDR-Associated SASP. 1 / 1
| 1
eidos
"MYSM1 Suppresses DDR-Associated SASP As DNA damage accumulation is an important factor that induces SASP , [ ."
33240758
MYSM1 affects Cellularity
| 1
MYSM1 activates Cellularity. 1 / 1
| 1
reach
"Loss of Mysm1 Causes Skin Atrophy and Reduced Skin Cellularity in Mysm1 Deficient Mice."
29495602
MYSM1 affects Cellular Senescence Aging Process Lifespan Abstract Aging
| 1
MYSM1 inhibits Cellular Senescence Aging Process Lifespan Abstract Aging. 1 / 1
| 1
eidos
"MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan Abstract Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases ."
33240758
MYSM1 affects Carcinogenesis
| 1
reach
"MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling."
34706761
MYSM1 affects CYLD
| 1
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
MYSM1 affects CLPS
| 1
MYSM1 inhibits CLPS. 1 / 1
| 1
reach
"We further establish that PUMA, but not p21, is an important mediator of the p53 driven hematopoietic dysfunction in Mysm1 deficiency, with Mysm1 -/- Puma -/- mice showing full rescue of MPP4 cell viability, partial rescue of HSC functions, but persistent depletion of CLPs and lymphopenia."
26768662
MYSM1 affects CDKN2A
| 1
MYSM1 inhibits CDKN2A. 1 / 1
| 1
reach
"Lymphoid cell depletion in Mysm1 deficiency was previously attributed to several mechanisms, involving either MYSM1 mediated Cdkn2a and p19 ARF repression to restrict p53 activation in thymocytes, 39 or MYSM1 mediated induction of lymphoid-lineage genes, such as Ebf1 and Id2."
26768662
MYSM1 affects CDKN1A
| 1
TP53 binds CDKN1A, BBC3, and MYSM1. 1 / 1
| 1
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 /PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a /p21."
26768662
MYSM1 affects CD8
| 1
MYSM1 activates CD8. 1 / 1
| 1
reach
"Mysm1 ablation resulted in a twofold reduction in CD8 + T-cell numbers, and also led to a hyperactivated CD8 + T-cell state accompanied by impaired proliferation and increased pro inflammatory cytokine production after ex vivo stimulation."
28066899
MYSM1 affects CD79A
| 1
Modified MYSM1 activates CD79A. 1 / 1
| 1
reach
"MYSM1 expression activated transcription of the Ebf1alpha promoter and modestly activated the Ebf1beta promoter, but only marginally activated the Pax5 promoter and Cd79a promoter."
22169041
MYSM1 affects BRCC36
| 1
MYSM1 binds BRCC36. 1 / 1
| 1
sparser
"Importantly, MYSM1 and BRCC36 are associated with complexes that activate their deubiquitinating activity."
26918171
MYSM1 affects B1a
| 1
MYSM1 activates B1a. 1 / 1
| 1
reach
"To identify potential miRNAs that are involved in MYSM1 induced B1a abnormality, we performed Quantitative Reverse Transcription PCR (qRT-PCR) assays to analyze the expression level of these miRNAs in B1a cells."
27590507
MYSM1 affects Autoimmunity
| 1
MYSM1 inhibits Autoimmunity. 1 / 1
| 1
eidos
"MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway ."
33086059
MYSM1 affects Atrophy
| 1
MYSM1 inhibits Atrophy. 1 / 1
| 1
reach
"Loss of Mysm1 Causes Skin Atrophy and Reduced Skin Cellularity in Mysm1 Deficient Mice."
29495602
MYSM1 affects Akt/c-Raf/GSK-3beta
| 1
MYSM1 inhibits Akt/c-Raf/GSK-3beta. 1 / 1
| 1
reach
"MYSM1 was able to bind to androgen receptor instead of increasing its expression and knockdown of MYSM1 resulted in activation of Akt/c-Raf/GSK-3beta signaling."
31761786
MYB affects MYSM1
| 1
MYSM1 binds MYB and HTH. 1 / 1
| 1
sparser
"Both genes contained two introns, encoded 257 amino acids with two-Aa difference, and carried the unabridged HTH-MYB, MYB-like DNA-binding, and SANT domains."
31035916
MSH6 affects POLD1
| 1
MYSM1 binds MSH6 and POLD1. 1 / 1
| 1
sparser
"Furthermore, mild interactions of MYSM1 with POLD1 and MSH6 and with Lamin B1, involved in higher-order chromatin structure and anchoring of chromatin, were detectable."
32466590
MED25 affects TCEA1
| 1
TCEA1 binds MED25, MYSM1, and DREB2A. 1 / 1
| 1
sparser
"MED25 physically interacts with abiotic-stress associated TFs, DREB2A, ZFHD1, and MYB-Like ( xref ;Table xref )."
28659948
KIF11 affects MYSM1
1 |
MYSM1 binds KIF11. 1 / 1
1 |
biogrid
No evidence text available
17707232
K63 affects STING1
| 1
STING1 binds MYSM1 and K63. 1 / 1
| 1
reach
"MYSM1 subsequently interacts with STING and cleaves STING K63 linked ubiquitination to suppress cGAS STING signaling."
33086059
IRF8 affects MYSM1
| 1
MYSM1 binds IRF8 and IRF2. 1 / 1
| 1
sparser
"We then tested Mysm1 binding to the promoter regions of IRF2 and IRF8 by analyzing WT (not Mysm1 −/− ) Lin − BM cells via a ChIP assay after in vitro stimulation with Poly(I:C) or IFN-γ."
27277682
IRF4 affects MYSM1
| 1
MYSM1 binds IRF4. 1 / 1
| 1
sparser
"However, the association of MYSM1 with IRF4 ( xref ), Stat3/5, NF-kB, and AP-1 at the Pax5 locus in naïve WT B cells was not positively identified in our assays."
26348977
IRF2 affects MYSM1
| 1
MYSM1 binds IRF8 and IRF2. 1 / 1
| 1
sparser
"We then tested Mysm1 binding to the promoter regions of IRF2 and IRF8 by analyzing WT (not Mysm1 −/− ) Lin − BM cells via a ChIP assay after in vitro stimulation with Poly(I:C) or IFN-γ."
27277682
IKZF1 affects STAT5
| 1
STAT5 binds IKZF1, MYSM1, Runx1, and PU.1. 1 / 1
| 1
sparser
"A weak association of endogenous MYSM1 protein and endogenous E2A (E47) protein was detected in WT BM Lin - progenitor cells, although the association of MYSM1 and PU.1, Ikaros, Stat5, or Runx1 was not positively identified (data not shown)."
22169041
IKK_complex affects MYSM1
| 1
sparser
"Remarkably, we found no direct interaction between MYSM1 and LUBAC or TAK1 or the IKK complex (NEMO, IKKα/β) (Figure  xref c.  xref and Fig.  xref )."
30405132
IFNG affects MYSM1
| 1
IFNG activates MYSM1. 1 / 1
| 1
eidos
"Mysm1 , a histone deubiquitinase , is induced by TNF-alpha and IFNgamma in ASCs and promotes miR-150 transcription , which enhances iNOS production ."
32363193
Hypersensitivity affects MYSM1
| 1
MYSM1 binds Hypersensitivity. 1 / 1
| 1
sparser
"IGS002 codes for a R2R3 Myb-like protein, which is associated with HR and programmed cell death (PCD) regulation in response to pathogen attack through induction of SA biosynthesis xref ."
21533105
Histone_H2B affects H2AC20
| 1
sparser
"In fact, MYSM1 is localized primarily to the nucleus and can directly interact with both H2A and H2B [ xref ]."
32708614
His2A affects MYSM1
| 1
His2A activates MYSM1. 1 / 1
| 1
reach
"Significantly, although cells were treated with DHT as usual, the amount of pS5-Pol II on the promoter was reduced upon loss of 2A-DUB and increased levels of uH2A, which argues that 2A-DUB and result[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
HTH affects PAC
| 1
MYSM1 binds PAC and HTH. 1 / 1
| 1
sparser
"An unexpectedly potent size regulator that emerged from our screens was Dot6, a Myb-like HTH transcription factor that binds to the PAC (Polymerase A and C) motif [ xref ]."
30921326
HTH affects MYB, and MYSM1
| 1
MYSM1 binds MYB and HTH. 1 / 1
| 1
sparser
"Both genes contained two introns, encoded 257 amino acids with two-Aa difference, and carried the unabridged HTH-MYB, MYB-like DNA-binding, and SANT domains."
31035916
HSPA1A affects MYSM1
1 |
MYSM1 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
17707232
HNRNPH1 affects MYSM1
1 |
MYSM1 binds HNRNPH1. 1 / 1
1 |
biogrid
No evidence text available
17707232
HELLS affects RFC5
| 1
MYSM1 binds HELLS, PCNA, and RFC5. 1 / 1
| 1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
32466590
HATs affects MYSM1
| 1
MYSM1 binds HATs. 1 / 1
| 1
reach
"The finding that two DUBs, 2A-DUB and USP22 associate with HATs suggests an important functional interplay between these classes of enzymes."
18430235
H2AC20 affects Histone_H2B, and MYSM1
| 1
sparser
"In fact, MYSM1 is localized primarily to the nucleus and can directly interact with both H2A and H2B [ xref ]."
32708614
GFI1 affects MYSM1
| 1
MYSM1 binds GFI1. 1 / 1
| 1
sparser
"We found that Mysm1 directly associates with the Gfi1 enhancer element and promotes its transcription through Gata2 and Runx1 transactivation."
24014243
FLT3 affects MYSM1
| 1
MYSM1 binds FLT3. 1 / 1
| 1
sparser
"MYSM1 bound to the Flt3 gene promoter, and loss of MYSM1 resulted in reduced recruitment of the major hematopoietic transcription factor PU.1 and an increase in repressive histone marks H2AK119ub and H3K27me3 at the Flt3 locus [ xref ] ( xref )."
32344625
EEF1A1 affects MYSM1
1 |
MYSM1 binds EEF1A1. 1 / 1
1 |
biogrid
No evidence text available
17707232
DREB2A affects TCEA1
| 1
TCEA1 binds MED25, MYSM1, and DREB2A. 1 / 1
| 1
sparser
"MED25 physically interacts with abiotic-stress associated TFs, DREB2A, ZFHD1, and MYB-Like ( xref ;Table xref )."
28659948
DNA-Binding Domain affects RAP1
| 1
sparser
"For this orientation of the recognition sequence, Rap1 binds with the N-terminal Myb-like region of its DNA-binding domain (DBD) facing the incoming polymerase and with the majority of the Rap1 contacts with the phosphate backbone of the DNA occurring on the non-template strand ( xref – xref )."
27001517
DICER1 affects MYSM1
1 |
DICER1 binds MYSM1. 1 / 1
1 |
biogrid
No evidence text available
24778252
DHPS affects MYSM1
| 1
DHPS binds MYSM1. 1 / 1
| 1
sparser
"At least one shelterin component, Rap1, is present in S. cerevisiae , although unlike vertebrate RAP1, ScRap1p directly binds ds telomeric DNA through two myb-like DNA binding domains and contributes to telomere length regulation and telomere silencing ( xref )."
19854131
DEGs affects MYSM1
| 1
DEGs inhibits MYSM1. 1 / 1
| 1
reach
"DEGs involved in epigenetic regulation include upregulatd NSD1 and downregulated KDM5A and MYSM1 (XREF_SUPPLEMENTARY)."
26324762
CYLD affects TNFAIP3
| 1
TNFAIP3 binds RNF31, OTULIN, CYLD, and MYSM1. 1 / 1
| 1
sparser
"Upon immunoprecipitation, we observed no direct interaction between MYSM1 with HOIP, NEMO or the negative regulators CYLD, OTULIN or A20 (Fig.  xref )."
30405132
CDKN1A affects TP53
| 1
TP53 binds CDKN1A, BBC3, and MYSM1. 1 / 1
| 1
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 /PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a /p21."
26768662
BRCC36 affects MYSM1
| 1
MYSM1 binds BRCC36. 1 / 1
| 1
sparser
"Importantly, MYSM1 and BRCC36 are associated with complexes that activate their deubiquitinating activity."
26918171
BMI1 affects RNF2
| 1
RNF2 binds BMI1, MYSM1, and PRC1. 1 / 1
| 1
sparser
"Loss of MYSM1 was associated with increased H2AK119Ub levels, increased recruitment of PRC1 components Ring1B and Bmi1, and reduced binding of hematopoietic transcription factors Gata2 and Runx1 to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
BBC3 affects TP53
| 1
TP53 binds CDKN1A, BBC3, and MYSM1. 1 / 1
| 1
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 /PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a /p21."
26768662
BACH2 affects MYSM1
| 1
BACH2 activates MYSM1. 1 / 1
| 1
reach
"XREF_FIG shows that mRNA levels of Pax5 and Bach2 were significantly reduced, while Blimp1 and Xbp1 mRNA levels were significantly elevated in naive and activated Mysm1 -/- B cells."
26348977
Adenoviridae Infections increases the amount of MYSM1. 1 / 1
| 1
reach
"For example, adenovirus infection leads to increased transcription of MYSM1, a repressor of STING signaling, thus enabling the virus to reduce IFN-I expression activated through the STING/TBK1/IRF3 pathway [67]."
35632630
ARF affects TP53
| 1
TP53 binds MYSM1 and ARF. 1 / 1
| 1
sparser
"In line with a previous report on Mysm1-binding to thep19 ARF -promoter in thymocytes [ xref ], an upstream regulator of TS p53, in Mysm1 −/− epidermal cells as well, mRNA expression ofp19 ARF was moderately increased along with increases in p53 levels and in apoptosis."
29495602
AR affects SWIRM domain
| 1
MYSM1 binds AR and SWIRM domain. 1 / 1
| 1
reach
"As 2A-DUB may interact with AR via its SWIRM domain (Metzger et al., 2005), recruitment of the complex might be AR dependent."
17707232
ABCG21 affects HMGS, MYSM1, OsRFPv-6, aquaporin, and methyltransferase activity
| 1
Methyltransferase activity binds MYSM1, HMGS, ABCG21, OsRFPv-6, and aquaporin. 1 / 1
| 1
sparser
"OsRFPv-6 interacted with early flowering 3 (ELF3) protein (Os01g38530), indole-3-glycerol phosphate synthase (Os08g23150), ABC transporter (Os03g08380), Myb-like DNA-binding domain-containing protein (Os02g04640), S-adenosylmethionine-dependent methyltransferase (Os03g36910), and aquaporin protein (Os07g26690)."
23571674
3,4-methylenedioxymethamphetamine increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
20188158
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
19770486
17alpha-ethynylestradiol increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
23129252
(-)-epigallocatechin 3-gallate increases the amount of MYSM1. 1 / 1
1 |
ctd
No evidence text available
22079256