IndraLab

Statements

MPND affects diphosphate(4-)
| 3
MPND activates diphosphate(4-). 3 / 3
| 3
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"Interestingly, the indolactam specific TleC and MpnD both accepted different chain lengths (from C 5 to C 25) of prenyl pyrophosphate in vitro."
26952246
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"Interestingly, both TleC and MpnD also accepted farnesyl pyrophosphate (FPP) (C 15), geranylgeranyl pyrophosphate (GGPP) (C 20) and geranylfarnesyl pyrophosphate (GFPP) (C 25) as prenyl donors, to produce 5, 6 and 7, respectively (XREF_FIG and XREF_SUPPLEMENTARY)."
26952246
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"In contrast to typical indole PTs that exhibit broad substrate specificities towards the prenyl acceptors but with strict specificities towards the prenyl donors XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR, it is remarkable that the indolactam specific TleC and MpnD exhibited unusually relaxed substrate specificities towards the prenyl donors and accepted different chain lengths (from C 5 to C 25) of prenyl pyrophosphate in vitro."
26952246
Valproic acid affects MPND
2 |
Valproic acid methylates MPND.
1 |
Valproic acid methylates MPND. 1 / 1
1 |
ctd
No evidence text available
29154799
Valproic acid decreases the amount of MPND.
1 |
Valproic acid decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
15901671
TleC affects MPND
| 2
MPND binds TleC. 2 / 2
| 2
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"The structural analysis of MpnD and TleC complexed with substrates suggested that the three amino acid residues Trp97, Phe170, and Ala173 in TleC and Tyr80, Trp157, and Met159 in MpnD regulate the selectivity of the length of prenyl donor and regiospecificity of prenylation position."
32180104
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"Furthermore, the crystal structures of TleC and MpnD complexed with the substrates suggested that the distance between the C-3 position of DMSPP and the C-7 position of 1 (3.3 A in TleC and 3.1 A in MpnD) is closer than that between the C-1 position of the prenyl substrates and the N-1 position of 1 (6.0 A in TleC and MpnD) (XREF_SUPPLEMENTARY)."
26952246
MPND is modified
2 |
MPND is phosphorylated on S181. 1 / 1
1 |
hprd
No evidence text available
17081983
MPND is phosphorylated on S178. 1 / 1
1 |
hprd
No evidence text available
17081983
MPND affects prenyl diphosphate
| 2
MPND activates prenyl diphosphate. 2 / 2
| 2
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"Thus, TleC and MpnD clearly prefer to accept GPP and DMAPP as the prenyl donors, respectively."
26952246
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"First, the indolactam specific TleC and MpnD both accepted DMAPP (C 5) and GPP (C 10) as substrates to produce pendolmycin (3), and lyngbyatoxin A (2) and 5-geranylindolactam V (4) (2:4 = 26:1 for TleC; 2:4 = 1:3 for MpnD), respectively (XREF_FIG)."
26952246
MPND affects TleC
| 2
MPND binds TleC. 2 / 2
| 2
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"The structural analysis of MpnD and TleC complexed with substrates suggested that the three amino acid residues Trp97, Phe170, and Ala173 in TleC and Tyr80, Trp157, and Met159 in MpnD regulate the selectivity of the length of prenyl donor and regiospecificity of prenylation position."
32180104
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"Furthermore, the crystal structures of TleC and MpnD complexed with the substrates suggested that the distance between the C-3 position of DMSPP and the C-7 position of 1 (3.3 A in TleC and 3.1 A in MpnD) is closer than that between the C-1 position of the prenyl substrates and the N-1 position of 1 (6.0 A in TleC and MpnD) (XREF_SUPPLEMENTARY)."
26952246
MPND affects DEG15
| 2
MPND activates DEG15. 2 / 2
| 2
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"First, the indolactam specific TleC and MpnD both accepted DMAPP (C 5) and GPP (C 10) as substrates to produce pendolmycin (3), and lyngbyatoxin A (2) and 5-geranylindolactam V (4) (2:4 = 26:1 for TleC; 2:4 = 1:3 for MpnD), respectively (XREF_FIG)."
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"Thus, TleC and MpnD clearly prefer to accept GPP and DMAPP as the prenyl donors, respectively."
26952246
Trichostatin A affects MPND
1 |
Trichostatin A decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
15901671
Thioacetamide affects MPND
1 |
Thioacetamide decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
23411599
Tetrachloroethene affects MPND
1 |
Tetrachloroethene decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
28973375
Sulforaphane affects MPND
1 |
Sulforaphane decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
31838189
Pregnenolone 16alpha-carbonitrile increases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
28903501
Methylmercury chloride decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
28001369
Methapyrilene affects MPND
1 |
Methapyrilene demethylates MPND. 1 / 1
1 |
ctd
No evidence text available
30157460
Jinfukang affects MPND
1 |
Jinfukang increases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
27392435
Hsa-miR-335-5p affects MPND
1 |
Hsa-miR-335-5p decreases the amount of MPND. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Hsa-let-7b-5p affects MPND
1 |
Hsa-let-7b-5p decreases the amount of MPND. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hexabromocyclododecane decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
29177809
Genistein affects MPND
1 |
Genistein increases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
18847459
Cyclosporin A affects MPND
1 |
Cyclosporin A decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
20106945
Copper(II) sulfate affects MPND
1 |
Copper(II) sulfate decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
19549813
Copper atom affects MPND
1 |
Copper atom increases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
30556269
Cobalt dichloride affects MPND
1 |
Cobalt dichloride decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
24386269
Clofibrate affects MPND
1 |
Clofibrate decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
23811191
Bisphenol A affects MPND
1 |
Bisphenol A methylates MPND. 1 / 1
1 |
ctd
No evidence text available
28505145
Benzo[e]pyrene affects MPND
1 |
Benzo[e]pyrene demethylates MPND. 1 / 1
1 |
ctd
No evidence text available
30157460
Benzo[a]pyrene affects MPND
1 |
Benzo[a]pyrene decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
20106945
Atrazine affects MPND
1 |
Atrazine decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
22378314
Aflatoxin B1 affects MPND
1 |
Aflatoxin B1 decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
27153756
Abrine affects MPND
1 |
Abrine decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
31054353
USP36 affects MPND
1 |
USP36 binds MPND. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP30 affects MPND
1 |
USP30 binds MPND. 1 / 1
1 |
biogrid
No evidence text available
19615732
MPND affects tumor penetration
| 1
MPND activates tumor penetration. 1 / 1
| 1
eidos
"Furthermore , using multicellular tumor spheroids to mimic in vivo experiment , MPND can enhance the tumor penetration and therapeutic effect for killing the deep tumor tissue at the central location ."
35007003
MPND affects pPAJV643
| 1
MPND activates pPAJV643. 1 / 1
| 1
eidos
"The mpnD gene encodes a prenyltransferase that , unlike TleC or LtxC , transfers a dimethylallyl group to the C-7 position of ILV to complete the biosynthesis of pendolmycin.7 Like the verification of tleC above , mpnD was cloned into the position of ltxC to create pPAJV643 ( ltxAB-mpnD ) ."
31846576
MPND affects migration breast cancer cells
| 1
MPND inhibits migration breast cancer cells. 1 / 1
| 1
eidos
"Results showed that MPND causes enhanced bioavailability , better cellular uptake , and inhibition of the migration of breast cancer cells as compared to the drug alone ."
35423422
MPND affects cellular uptake
| 1
MPND activates cellular uptake. 1 / 1
| 1
eidos
"Results showed that MPND causes enhanced bioavailability , better cellular uptake , and inhibition of the migration of breast cancer cells as compared to the drug alone ."
35423422
MPND affects active proteins
| 1
MPND activates active proteins. 1 / 1
| 1
eidos
"These results show that the codon-optimized tleC , tleD , and mpnD all produce active proteins with the expected activity when heterologously expressed in Anabaena 7120.9 , 15 This demonstrates that the native levels of transcriptional and translational regulation exerted when these genes occupy the same positions as ltxC ( tleC , mpnD ) and ltxD ( tleD ) in the ltx gene cluster are sufficient to produce proteins that efficiently catalyzed the desired reactions ; each protein completely converted its substrate to the expected product ( s ) because 1 was not observed in extracts of ltxABC-tleD or ltxAB-mpnD ."
31846576
MPND affects USP36
1 |
USP36 binds MPND. 1 / 1
1 |
biogrid
No evidence text available
19615732
MPND affects USP30
1 |
USP30 binds MPND. 1 / 1
1 |
biogrid
No evidence text available
19615732
MPND affects Therapeutics
| 1
MPND activates Therapeutics. 1 / 1
| 1
eidos
"Furthermore , using multicellular tumor spheroids to mimic in vivo experiment , MPND can enhance the tumor penetration and therapeutic effect for killing the deep tumor tissue at the central location ."
35007003
MPND affects Neoplasms
| 1
MPND activates Neoplasms. 1 / 1
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"Furthermore, using multicellular tumor spheroids to mimic in vivo experiment, MPND can enhance the tumor penetration and therapeutic effect for killing the deep tumor tissue at the central location."
35007003
MPND affects Histone
| 1
Histone binds MPND. 1 / 1
| 1
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"Moreover, the DNA and the two acidic regions of MPND synergistically enhance the interaction between MPND and histones."
36834777
MPND affects E7
1 |
MPND binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
MPND affects DOX
| 1
MPND decreases the amount of DOX. 1 / 1
| 1
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"When the MPND is internalized into the cancer cell, the rupture of -S-S- bridges and the degradation of MPND occur in the tumor microenvironment with a high level of GSH, inducing the on-demand release of DOX."
35007003
MPND affects C5
| 1
MPND activates C5. 1 / 1
| 1
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"This would be the reason why MpnD produces not only the C-7 ' reverse ' prenylation product 2 but also the C-5 ' normal ' prenylation product 4."
26952246
MPND activates Biological Availability. 1 / 1
| 1
eidos
"Results showed that MPND causes enhanced bioavailability , better cellular uptake , and inhibition of the migration of breast cancer cells as compared to the drug alone ."
35423422
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"Interestingly, both TleC and MpnD also accepted farnesyl pyrophosphate (FPP) (C 15), geranylgeranyl pyrophosphate (GGPP) (C 20) and geranylfarnesyl pyrophosphate (GFPP) (C 25) as prenyl donors, to produce 5, 6 and 7, respectively (XREF_FIG and XREF_SUPPLEMENTARY)."
26952246
Histone affects MPND
| 1
Histone binds MPND. 1 / 1
| 1
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"Moreover, the DNA and the two acidic regions of MPND synergistically enhance the interaction between MPND and histones."
36834777
GSK-J4 affects MPND
1 |
GSK-J4 decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
29301935
E7 affects MPND
1 |
MPND binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
2-hydroxypropanoic acid decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
30851411
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of MPND. 1 / 1
1 |
ctd
No evidence text available
26290441