IndraLab

Statements

JOSD1 inhibits Neoplasms. 3 / 3

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"Additionally, JOSD1 suppression inhibited the tumor growth and improved chemosensitivity in vivo."

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"Furthermore, we found the high expression of Ki67 in JOSD1-depleted xenografts, indicating that JOSD1 could accelerate tumor proliferation in HNSCC."

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"In our study, JOSD1 knockdown could inhibit the growth and colony formation of TSCCA and SCC25 cells, and suppress the tumor growth in vivo."

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JOSD1 activates Neoplasms. 3 / 3

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eidos

"Furthermore , we found the high expression of Ki67 in JOSD1-depleted xenografts , indicating that JOSD1 could accelerate tumor proliferation in HNSCC ."

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"Knockdown of JOSD1 attenuates tumor growth and improves chemosensitivity of HNSCC cells in vivo."

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"Furthermore, we found the high expression of Ki67 in JOSD1-depleted xenografts, indicating that JOSD1 could accelerate tumor proliferation in HNSCC."

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SOCS1 binds JOSD1. 3 / 3

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"JOSD1 physically interacts with SOCS1, which is an essential negative regulator of many cytokines signaling, and enhances SOCS1 stability by deubiquitinating K48-linked polyubiquitination of SOCS1."

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biogrid

No evidence text available

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"JOSD1 physically interacts with SOCS1, which is an essential negative regulator of many cytokines signaling, and enhances SOCS1 stability by deubiquitinating K48 linked polyubiquitination of SOCS1."

28355105

JOSD1 ubiquitinates SOCS1.

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JOSD1 leads to the ubiquitination of SOCS1. 1 / 1

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"JOSD1 Negatively Regulates Type-I Interferon Antiviral Activity by Deubiquitinating and Stabilizing SOCS1."

28355105

JOSD1 deubiquitinates SOCS1.

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JOSD1 deubiquitinates SOCS1. 1 / 1

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ubibrowser

"JOSD1 Negatively Regulates Type-I Interferon Antiviral Activity by Deubiquitinating and Stabilizing SOCS1"

28355105

BRD4 increases the amount of JOSD1.

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BRD4 increases the amount of JOSD1. 2 / 2

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"Taken together, these evidences illustrate that BRD4, as an epigenetic modulator, enhances the expression of JOSD1 by facilitating its transcription activation."

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"Besides, we found that knockdown of BRD4 by shRNA, resembling the effect of JQ1, inhibited the expression of JOSD1 (Fig. 2e, f), while BRD4 overexpression significantly upregulated JOSD1 in HNSCC cells (Fig. 2g, h), suggesting that BRD4 affected JOSD1 expression at the transcriptional level."

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BRD4 activates JOSD1.

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BRD4 activates JOSD1. 2 / 2

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eidos

"BRD4 inhibition downregulates JOSD1 in HNSCC ."

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eidos

"Taken together , these evidences illustrate that BRD4 , as an epigenetic modulator , enhances the expression of JOSD1 by facilitating its transcription activation ."

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BRD4 decreases the amount of JOSD1.

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BRD4 decreases the amount of JOSD1. 1 / 1

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2,3,7,8-tetrachlorodibenzodioxine affects JOSD1

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2,3,7,8-tetrachlorodibenzodioxine increases the amount of JOSD1. 5 / 5

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ctd

No evidence text available

16214954

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ctd

No evidence text available

21889950

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ctd

No evidence text available

25975270

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ctd

No evidence text available

23994337

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ctd

No evidence text available

15328365

UBC affects JOSD1

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UBC binds JOSD1. 4 / 4

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biogrid

No evidence text available

19382171

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biogrid

No evidence text available

19382171

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biogrid

No evidence text available

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biogrid

No evidence text available

21118805

JOSD1 affects cell population proliferation

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JOSD1 activates cell population proliferation.

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JOSD1 activates cell population proliferation. 3 / 3

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"Furthermore, we found the high expression of Ki67 in JOSD1-depleted xenografts, indicating that JOSD1 could accelerate tumor proliferation in HNSCC."

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"Furthermore, JOSD1 silencing could inhibit proliferation and enhance chemosensitivity of HNSCC cells in vitro and in vivo."

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"JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4."

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JOSD1 inhibits cell population proliferation.

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JOSD1 inhibits cell population proliferation. 1 / 1

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"Furthermore, we found the high expression of Ki67 in JOSD1-depleted xenografts, indicating that JOSD1 could accelerate tumor proliferation in HNSCC."

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JOSD1 affects UBC

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UBC binds JOSD1. 4 / 4

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biogrid

No evidence text available

19382171

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biogrid

No evidence text available

19382171

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biogrid

No evidence text available

23625928

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biogrid

No evidence text available

21118805

JOSD1 affects MCL1

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JOSD1 binds MCL1.

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JOSD1 binds MCL1. 3 / 3

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"Further research showed that curcumol-induced Mcl-1 Ser159 phosphorylation is required to disrupt the interaction between deubiquitinase JOSD1 and Mcl-1 and eventually induce Mcl-1 ubiquitination and degradation."

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"TRAF4 knockout inhibited the phosphorylation of Akt and upregulated GSK3β activity, resulting in increased myeloid cell leukemia-1 (MCL-1) S159 phosphorylation, which disrupted the interaction of MCL-1 with Josephin domain containing 1 (JOSD1), and ultimately induced MCL-1 ubiquitination and degradation."

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36869017

JOSD1 activates MCL1.

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JOSD1 activates MCL1. 1 / 1

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"JOSD1 overexpression caused chemoresistance in gynaecological cancer by upregulating the MCL1 protein."

31043700

JOSD1 affects HNSCC

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JOSD1 activates HNSCC.

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JOSD1 activates HNSCC. 3 / 3

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"Furthermore, we found the high expression of Ki67 in JOSD1-depleted xenografts, indicating that JOSD1 could accelerate tumor proliferation in HNSCC."

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"Compared with sensitive specimens, JOSD1 expression was dramatically increased in chemoresistant tissues (Fig. 1d), indicating a potential role of JOSD1 in HNSCC chemoresistance."

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"In summary, these data demonstrate that JOSD1 upregulation in HNSCC positively correlated with poor prognosis of patients, uncovering the clinical prognostic significance of JOSD1."

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JOSD1 inhibits HNSCC.

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JOSD1 inhibits HNSCC. 1 / 1

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"Furthermore, we found the high expression of Ki67 in JOSD1-depleted xenografts, indicating that JOSD1 could accelerate tumor proliferation in HNSCC."

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CREB1 affects JOSD1

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CREB1 decreases the amount of JOSD1. 4 / 4

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

Cyclosporin A affects JOSD1

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Cyclosporin A increases the amount of JOSD1. 3 / 3

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ctd

No evidence text available

27989131

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ctd

No evidence text available

20106945

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ctd

No evidence text available

25562108

SOCS1 affects JOSD1

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SOCS1 binds JOSD1. 3 / 3

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"JOSD1 physically interacts with SOCS1, which is an essential negative regulator of many cytokines signaling, and enhances SOCS1 stability by deubiquitinating K48-linked polyubiquitination of SOCS1."

28355105

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biogrid

No evidence text available

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"JOSD1 physically interacts with SOCS1, which is an essential negative regulator of many cytokines signaling, and enhances SOCS1 stability by deubiquitinating K48 linked polyubiquitination of SOCS1."

28355105

MCL1 affects JOSD1

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JOSD1 binds MCL1. 3 / 3

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sparser

36869017

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36869017

JOSD1 affects tumor growth

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JOSD1 activates tumor growth. 3 / 3

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"JOSD1 knockdown impedes tumor growth and increases chemosensitivity of HNSCC cells in vivo ."

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"Additionally , JOSD1 suppression inhibited the tumor growth and improved chemosensitivity in vivo ."

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"In our study , JOSD1 knockdown could inhibit the growth and colony formation of TSCCA and SCC25 cells , and suppress the tumor growth in vivo ."

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JOSD1 affects apoptotic process

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JOSD1 inhibits apoptotic process.

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JOSD1 inhibits apoptotic process. 2 / 2

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"Using siRNA-mediated JOSD1 knockdown, we confirmed that the loss of JOSD1 could markedly increase the apoptosis of gynecological cancer cells ."

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"Moreover, with the treatment of CDDP, JOSD1 knockdown could increase expression of apoptosis-related proteins and promote cell apoptosis rate."

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JOSD1 activates apoptotic process.

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JOSD1 activates apoptotic process. 1 / 1

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"JOSD1 depletion led to severe apoptosis in gynaecological cancer cells both in vivo and in vitro."

31043700

Cisplatin affects JOSD1

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Cisplatin increases the amount of JOSD1.

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Cisplatin increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

27594783

Cisplatin activates JOSD1.

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Cisplatin activates JOSD1. 1 / 1

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"The results of MTT assay showed that the IC50 value of CDDP was dramatically reduced in the HNSCC cells expressing JOSD1 shRNAs, indicating that JOSD1 knockdown could sensitize HNSCC cells to CDDP (Fig. 4c)."

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Bisphenol A affects JOSD1

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Bisphenol A increases the amount of JOSD1. 2 / 2

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ctd

No evidence text available

30816183

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ctd

No evidence text available

25181051

TRIM27 affects JOSD1

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JOSD1 binds TRIM27. 2 / 2

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biogrid

No evidence text available

21516116

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biogrid

No evidence text available

25416956

SREBF1 affects JOSD1

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SREBF1 decreases the amount of JOSD1. 2 / 2

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

PITX2 affects JOSD1

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PITX2 decreases the amount of JOSD1. 2 / 2

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

JOSD1 is modified

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JOSD1 is ubiquitinated. 2 / 2

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"The ubiquitination of JosD1 triggers its localization to the membrane from the cytoskeletal fraction [ xref ]."

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"Notably, JOSD1’s ubiquitination can regulate its catalytic activity, but this modification is not necessary for JOSD2 to exert its DUB function."

32982735

NHLH1 affects JOSD1

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NHLH1 decreases the amount of JOSD1. 2 / 2

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

LEF1 affects JOSD1

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LEF1 decreases the amount of JOSD1. 2 / 2

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

JOSD1 affects cell motility

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JOSD1 activates cell motility. 1 / 2

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"Indeed, time-lapse imaging revealed that JosD1 enhances membrane dynamics and cell motility."

23625928

JOSD1 affects cell growth

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JOSD1 activates cell growth. 2 / 2

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eidos

"Under the regulation of BRD4 , JOSD1 is a key driver of cell growth and chemoresistance in vitro and in vivo ."

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"Under the regulation of BRD4, JOSD1 is a key driver of cell growth and chemoresistance in vitro and in vivo."

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JOSD1 affects TRIM27

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JOSD1 binds TRIM27. 2 / 2

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biogrid

No evidence text available

21516116

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biogrid

No evidence text available

25416956

JOSD1 affects EIF3F

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JOSD1 binds EIF3F. 2 / 2

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biogrid

No evidence text available

26186194

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biogrid

No evidence text available

28514442

Zinc atom affects JOSD1

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Zinc atom increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

18593933

Valproic acid affects JOSD1

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Valproic acid increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

29154799

Tris(1,3-dichloro-2-propyl)phosphate affects JOSD1

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Tris(1,3-dichloro-2-propyl)phosphate increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

26179874

Tetrachloroethene affects JOSD1

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Tetrachloroethene increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

28973375

Sunitinib affects JOSD1

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Sunitinib increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

31533062

Sulindac affects JOSD1

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Sulindac decreases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

24136188

Positive regulation of NF-kappaB transcription factor activity affects JOSD1

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Positive regulation of NF-kappaB transcription factor activity activates JOSD1. 1 / 1

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"We found that NF-kappaB activation through each of these agents elicited a significant increase in APOBEC3B gene expression with less robust activation of APOBEC3C and no effect on JOSD1 ."

33238122

Pirinixic acid affects JOSD1

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Pirinixic acid increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

18301758

Paracetamol affects JOSD1

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Paracetamol increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

29067470

Pantogab affects JOSD1

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Pantogab increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

17379144

Nickel atom affects JOSD1

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Nickel atom increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

23195993

Nefazodone affects JOSD1

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Nefazodone increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

24136188

Methyltestosterone affects JOSD1

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Methyltestosterone decreases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

29191790

Methyl methanesulfonate affects JOSD1

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Methyl methanesulfonate increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

23649840

Leflunomide affects JOSD1

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Leflunomide increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

24136188

Jinfukang affects JOSD1

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Jinfukang increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

27392435

Indometacin affects JOSD1

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Indometacin increases the amount of JOSD1. 1 / 1

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ctd

No evidence text available

28201806

Hsa-miR-92b-3p affects JOSD1

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Hsa-miR-92b-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-92a-3p affects JOSD1

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Hsa-miR-92a-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-7847-3p affects JOSD1

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Hsa-miR-7847-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-769-5p affects JOSD1

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Hsa-miR-769-5p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-6864-3p affects JOSD1

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Hsa-miR-6864-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-6849-3p affects JOSD1

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Hsa-miR-6849-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-6771-5p affects JOSD1

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Hsa-miR-6771-5p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-6746-5p affects JOSD1

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Hsa-miR-6746-5p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-6500-3p affects JOSD1

1 |

Hsa-miR-6500-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-650 affects JOSD1

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Hsa-miR-650 decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-4802-3p affects JOSD1

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Hsa-miR-4802-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-4796-3p affects JOSD1

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Hsa-miR-4796-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-4786-5p affects JOSD1

1 |

Hsa-miR-4786-5p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-4524b-3p affects JOSD1

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Hsa-miR-4524b-3p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-4443 affects JOSD1

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Hsa-miR-4443 decreases the amount of JOSD1. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-4293 affects JOSD1

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Hsa-miR-4293 decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-3978 affects JOSD1

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Hsa-miR-3978 decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-3688-3p affects JOSD1

1 |

Hsa-miR-3688-3p decreases the amount of JOSD1. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-3672 affects JOSD1

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Hsa-miR-3672 decreases the amount of JOSD1. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-3614-5p affects JOSD1

1 |

Hsa-miR-3614-5p decreases the amount of JOSD1. 1 / 1

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biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-3612 affects JOSD1

1 |

Hsa-miR-3612 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-32-5p affects JOSD1

1 |

Hsa-miR-32-5p decreases the amount of JOSD1. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-30e-5p affects JOSD1

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Hsa-miR-30e-5p decreases the amount of JOSD1. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-30d-5p affects JOSD1

1 |

Hsa-miR-30d-5p decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-30c-5p affects JOSD1

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Hsa-miR-30c-5p decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-30b-5p affects JOSD1

1 |

Hsa-miR-30b-5p decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-30a-5p affects JOSD1

1 |

Hsa-miR-30a-5p decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-26b-5p affects JOSD1

1 |

Hsa-miR-26b-5p decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

19088304

Hsa-miR-2392 affects JOSD1

1 |

Hsa-miR-2392 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-186-5p affects JOSD1

1 |

Hsa-miR-186-5p decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-1827 affects JOSD1

1 |

Hsa-miR-1827 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-1324 affects JOSD1

1 |

Hsa-miR-1324 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-107 affects JOSD1

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Hsa-miR-107 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-103a-3p affects JOSD1

1 |

Hsa-miR-103a-3p decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Flutamide affects JOSD1

1 |

Flutamide increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

24136188

Finasteride affects JOSD1

1 |

Finasteride increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

24136188

Facilitating transcription activation affects JOSD1

| 1

Facilitating transcription activation activates JOSD1. 1 / 1

| 1

➶

eidos

"Taken together , these evidences illustrate that BRD4 , as an epigenetic modulator , enhances the expression of JOSD1 by facilitating its transcription activation ."

34261480

Epigenetic regulator BRD4 affects JOSD1

| 1

Epigenetic regulator BRD4 activates JOSD1. 1 / 1

| 1

➶

eidos

"The epigenetic regulator BRD4 contributed to the upregulation of JOSD1 in HNSCC ."

34261480

Diuron affects JOSD1

1 |

Diuron increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

21551480

Dibutyl phthalate affects JOSD1

1 |

Dibutyl phthalate increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

21266533

Beta-naphthoflavone affects JOSD1

1 |

Beta-naphthoflavone increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

23994337

Benzene affects JOSD1

1 |

Benzene increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

19162166

Administration JQ1 cells affects JOSD1

| 1

Administration JQ1 cells inhibits JOSD1. 1 / 1

| 1

➶

eidos

"The results showed that the administration of JQ1 to HNSCC cells strikingly downregulated JOSD1 in mRNA and protein level ( Fig. 2c , d ) ."

34261480

Abrine affects JOSD1

1 |

Abrine increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

31054353

Zoledronic Acid affects JOSD1

1 |

Zoledronic Acid increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

20977926

USP28 affects JOSD1

1 |

USP28 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

USP21c affects JOSD1

| 1

USP21c activates JOSD1. 1 / 1

| 1

➶

reach

"In addition, USP21c has been shown to cause complete removal of ubiquitin chains from not only itself, but also JOSD1 (XREF_FIG b)."

28659380

USP21 affects JOSD1

1 |

USP21 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

USP15 affects JOSD1

1 |

USP15 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

TRIM63 affects JOSD1

1 |

TRIM63 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

TRIM54 affects JOSD1

1 |

TRIM54 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

TRIM23 affects JOSD1

1 |

JOSD1 binds TRIM23. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

TRAF1 affects JOSD1

1 |

TRAF1 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

TIMM8A affects JOSD1

1 |

TIMM8A binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

TCF3 affects JOSD1

1 |

TCF3 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

Sesame Oil affects JOSD1

1 |

Sesame Oil increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

29191790

STUB1 affects JOSD1

1 |

STUB1 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

23625928

SP1 affects JOSD1

1 |

SP1 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

POU6F1 affects JOSD1

1 |

POU6F1 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

PJA1 affects JOSD1

1 |

PJA1 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

PCI 5002 affects JOSD1

1 |

PCI 5002 increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

18593933

PAX2 affects JOSD1

1 |

PAX2 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

NOTCH2NLA affects JOSD1

1 |

JOSD1 binds NOTCH2NLA. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

NFE2L2 affects JOSD1

1 |

NFE2L2 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

MYC affects JOSD1

1 |

MYC decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

MID2 affects JOSD1

1 |

JOSD1 binds MID2. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

MAFG affects JOSD1

1 |

MAFG decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

LNX1 affects JOSD1

1 |

JOSD1 binds LNX1. 1 / 1

1 |

➶

biogrid

No evidence text available

22889411

LMO2 affects JOSD1

1 |

LMO2 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

KRTAP9-2 affects JOSD1

1 |

KRTAP9-2 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

KRTAP5-9 affects JOSD1

1 |

KRTAP5-9 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

KRTAP10-8 affects JOSD1

1 |

KRTAP10-8 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

KRTAP10-4 affects JOSD1

1 |

KRTAP10-4 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

KRTAP10-3 affects JOSD1

1 |

KRTAP10-3 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

KRT40 affects JOSD1

1 |

KRT40 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

KRT31 affects JOSD1

1 |

JOSD1 binds KRT31. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

K 7174 affects JOSD1

1 |

K 7174 increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

24086573

JQ1 affects JOSD1

| 1

JQ1 inhibits JOSD1. 1 / 1

| 1

➶

reach

"The results showed that the administration of JQ1 to HNSCC cells strikingly downregulated JOSD1 in mRNA and protein level (Fig. 2c, d)."

34261480

JOSD1 affects tumor cell

| 1

JOSD1 activates tumor cell. 1 / 1

| 1

➶

eidos

"Furthermore , we found that JOSD1 knockdown suppressed tumor cell proliferation and metastasis , whereas overexpression of JOSD1 led to opposite phenotypes ."

35693075

JOSD1 affects tumor cell invasion

| 1

JOSD1 activates tumor cell invasion. 1 / 1

| 1

➶

eidos

"Indeed , JOSD1 promoted tumor cell invasion as well as metastasis on the dependence of Snail ."

35693075

JOSD1 affects signal cascade

| 1

JOSD1 inhibits signal cascade. 1 / 1

| 1

➶

eidos

"JOSD1 inhibits the IFN signal cascade via deubiquitinating and stabilizing SOCS1 [ 92 ] ."

32650621

JOSD1 affects pathway

| 1

JOSD1 inhibits pathway. 1 / 1

| 1

➶

sparser

"JOSD1 inhibits the mitochondrial apoptosis pathway and exerts anti-apoptosis effects and results in chemo-resistance in gynaecological cancer by stabilizing MCL1."

32982735

JOSD1 affects metastasis dependence Snail

| 1

JOSD1 activates metastasis dependence Snail. 1 / 1

| 1

➶

eidos

"Indeed , JOSD1 promoted tumor cell invasion as well as metastasis on the dependence of Snail ."

35693075

JOSD1 affects localization

| 1

JOSD1 activates localization. 1 / 1

| 1

➶

reach

"The ubiquitination of JosD1 triggers its localization to the membrane from the cytoskeletal fraction [38]."

32512887

JOSD1 affects growth colony TSCCA SCC25 cells

| 1

JOSD1 activates growth colony TSCCA SCC25 cells. 1 / 1

| 1

➶

eidos

"In our study , JOSD1 knockdown could inhibit the growth and colony formation of TSCCA and SCC25 cells , and suppress the tumor growth in vivo ."

34261480

JOSD1 affects defense response to virus

| 1

JOSD1 inhibits defense response to virus. 1 / 1

| 1

➶

reach

"JOSD1 has been identified to negatively regulate IFN-I-induced signaling and the antiviral response by deubiquitinating the K48-linked polyubiquitination of SOCS1, which is an essential negative regulator of many cytokine signaling pathways (120)."

34707613

JOSD1 affects cisplatin-induced apoptosis HNSCC cells

| 1

JOSD1 inhibits cisplatin-induced apoptosis HNSCC cells. 1 / 1

| 1

➶

eidos

"Moreover , JOSD1 depletion dramatically impaired cell proliferation and colony formation , and promoted cisplatin-induced apoptosis of HNSCC cells in vitro ."

34261480

JOSD1 affects chemosensitivity HNSCC cells

| 1

JOSD1 inhibits chemosensitivity HNSCC cells. 1 / 1

| 1

➶

eidos

"JOSD1 knockdown impedes tumor growth and increases chemosensitivity of HNSCC cells in vivo ."

34261480

JOSD1 affects chemoresistance

| 1

JOSD1 activates chemoresistance. 1 / 1

| 1

➶

eidos

"Under the regulation of BRD4 , JOSD1 is a key driver of cell growth and chemoresistance in vitro and in vivo ."

34261480

JOSD1 affects chemoresistance head neck squamous cell carcinoma epigenetic regulation enzymes

| 1

JOSD1 activates chemoresistance head neck squamous cell carcinoma epigenetic regulation enzymes. 1 / 1

| 1

➶

eidos

"JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4 Background Deubiquitinating enzymes ( DUBs ) play critical roles in various cancers by modulating functional proteins post-translationally ."

34261480

JOSD1 affects chemoresistance head neck squamous cell carcinoma epigenetic regulation BRD4

| 1

JOSD1 activates chemoresistance head neck squamous cell carcinoma epigenetic regulation BRD4. 1 / 1

| 1

➶

eidos

"JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4 ."

34261480

JOSD1 affects cell apoptosis

| 1

JOSD1 inhibits cell apoptosis. 1 / 1

| 1

➶

eidos

"Moreover , with the treatment of CDDP , JOSD1 knockdown could increase expression of apoptosis-related proteins and promote cell apoptosis rate ."

34261480

JOSD1 affects capacity colony

| 1

JOSD1 activates capacity colony. 1 / 1

| 1

➶

eidos

"Moreover , reduced level of JOSD1 impaired the capacity of colony formation in both TSCCA and SCC25 cells ( Fig. 5b ) ."

34261480

JOSD1 affects apoptosis-related proteins

| 1

JOSD1 inhibits apoptosis-related proteins. 1 / 1

| 1

➶

eidos

"Moreover , with the treatment of CDDP , JOSD1 knockdown could increase expression of apoptosis-related proteins and promote cell apoptosis rate ."

34261480

JOSD1 affects apoptosis HNSCC cells treated CDDP flow cytometry

| 1

JOSD1 inhibits apoptosis HNSCC cells treated CDDP flow cytometry. 1 / 1

| 1

➶

eidos

"Meanwhile , we found that depletion of JOSD1 led to a significant increase of apoptosis rate of HNSCC cells treated with CDDP by using flow cytometry ( Fig. 4d ) ."

34261480

JOSD1 affects acquired chemoresistance

| 1

JOSD1 activates acquired chemoresistance. 1 / 1

| 1

➶

eidos

"In gynaecological cancer , JOSD1 promotes acquired chemoresistance by stabilizing MCL1 [ 14 ] ."

34261480

JOSD1 affects USP28

1 |

USP28 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

JOSD1 affects USP21

1 |

USP21 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

JOSD1 affects USP15

1 |

USP15 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

JOSD1 affects TRIM63

1 |

TRIM63 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

JOSD1 affects TRIM54

1 |

TRIM54 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

JOSD1 affects TRIM23

1 |

JOSD1 binds TRIM23. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects TRAF1

1 |

TRAF1 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects TIMM8A

1 |

TIMM8A binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

JOSD1 affects Squamous Cell Carcinoma of Head and Neck

| 1

JOSD1 activates Squamous Cell Carcinoma of Head and Neck. 1 / 1

| 1

➶

reach

"JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4."

34261480

JOSD1 affects STUB1

1 |

STUB1 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

23625928

JOSD1 affects PJA1

1 |

PJA1 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

22626734

JOSD1 affects Neoplasm Metastasis

| 1

JOSD1 activates Neoplasm Metastasis. 1 / 1

| 1

➶

eidos

"Furthermore , we found that JOSD1 knockdown suppressed tumor cell proliferation and metastasis , whereas overexpression of JOSD1 led to opposite phenotypes ."

35693075

JOSD1 affects NOTCH2NLA

1 |

JOSD1 binds NOTCH2NLA. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects MID2

1 |

JOSD1 binds MID2. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects LNX1

1 |

JOSD1 binds LNX1. 1 / 1

1 |

➶

biogrid

No evidence text available

22889411

JOSD1 affects KRTAP9-2

1 |

KRTAP9-2 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects KRTAP5-9

1 |

KRTAP5-9 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects KRTAP10-8

1 |

KRTAP10-8 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects KRTAP10-4

1 |

KRTAP10-4 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects KRTAP10-3

1 |

KRTAP10-3 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects KRT40

1 |

KRT40 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects KRT31

1 |

JOSD1 binds KRT31. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

JOSD1 affects JOSD1

| 1

JOSD1 activates JOSD1. 1 / 1

| 1

➶

reach

"Compared with sensitive specimens, JOSD1 expression was dramatically increased in chemoresistant tissues (Fig. 1d), indicating a potential role of JOSD1 in HNSCC chemoresistance."

34261480

JOSD1 affects JAK2-V617F

| 1

JOSD1 binds JAK2-V617F. 1 / 1

| 1

➶

reach

"JOSD1 interacts with and stabilizes JAK2-V617F, and inactivation of the DUB leads to JAK2-V617F protein degradation by increasing its ubiquitination levels, thereby shortening its protein half-life."

34326465

JOSD1 affects HNSCC cell

| 1

JOSD1 activates HNSCC cell. 1 / 1

| 1

➶

eidos

"JOSD1 depletion inhibits HNSCC cell proliferation in vitro ."

34261480

JOSD1 affects ELAVL1

1 |

JOSD1 binds ELAVL1. 1 / 1

1 |

➶

biogrid

No evidence text available

19322201

JOSD1 affects CDDP treating HNSCC

| 1

JOSD1 inhibits CDDP treating HNSCC. 1 / 1

| 1

➶

eidos

"Meanwhile , JOSD1 silencing combined with CDDP treatment extremely enhanced the positive staining of cleaved Caspase-3 compared with the other three groups ( Fig. 6c ) , which indicated that JOSD1 knockdown could improve the effect of CDDP for treating HNSCC in vivo ."

34261480

JOSD1 affects CALM1

1 |

CALM1 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

JAK2-V617F affects JOSD1

| 1

JOSD1 binds JAK2-V617F. 1 / 1

| 1

➶

reach

34326465

Ischemia affects JOSD1

1 |

Ischemia increases the amount of JOSD1. 1 / 1

1 |

➶

bel

"Table 1 - Lists of differentially expressed genes during ischemia and reperfusion identified with SAM, as described in the text"

15867790

ICG 001 affects JOSD1

1 |

ICG 001 increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

26191083

Grape Seed Proanthocyanidins affects JOSD1

1 |

Grape Seed Proanthocyanidins decreases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

24763279

GFI1 affects JOSD1

1 |

GFI1 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

ELAVL1 affects JOSD1

1 |

JOSD1 binds ELAVL1. 1 / 1

1 |

➶

biogrid

No evidence text available

19322201

E4F1 affects JOSD1

1 |

E4F1 decreases the amount of JOSD1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

D-glucopyranose affects JOSD1

1 |

D-glucopyranose increases the amount of JOSD1. 1 / 1

1 |

➶

ctd

No evidence text available

22634610

CALM1 affects JOSD1

1 |

CALM1 binds JOSD1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

BRD4 shRNA resembling JQ1 affects JOSD1

| 1

BRD4 shRNA resembling JQ1 activates JOSD1. 1 / 1

| 1

➶

eidos

"Besides , we found that knockdown of BRD4 by shRNA , resembling the effect of JQ1 , inhibited the expression of JOSD1 ( Fig. 2e , f ) , while BRD4 overexpression significantly upregulated JOSD1 in HNSCC cells ( Fig. 2g , h ) , suggesting that BRD4 affected JOSD1 expression at the transcriptional level ."

34261480

BRD4 overexpression affects JOSD1

| 1

BRD4 overexpression activates JOSD1. 1 / 1

| 1

➶

eidos

"Besides , we found that knockdown of BRD4 by shRNA , resembling the effect of JQ1 , inhibited the expression of JOSD1 ( Fig. 2e , f ) , while BRD4 overexpression significantly upregulated JOSD1 in HNSCC cells ( Fig. 2g , h ) , suggesting that BRD4 affected JOSD1 expression at the transcriptional level ."

34261480