IndraLab

Statements


USP42 binds TP53.
3 | 1 3
3 | 1 3

sparser
"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals including Dox [ xref ].."

No evidence text available

sparser
"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals."

reach
"It has been reported that USP42 interacts with and deubiquitinates p53."

No evidence text available

sparser
"Usp42 forms a direct complex with p53 and controls its activation in response to cellular stress; as a result it regulates p53-dependent transcription and cell cycle arrest."

No evidence text available
USP42 deubiquitinates TP53.
1 | 5
USP42 deubiquitinates TP53. 6 / 6
1 | 5

reach
"It has been reported that USP42 interacts with and deubiquitinates p53."

reach
"In the initial phases of a stress response, USP42 deubiquitinates p53 by forming a direct complex with p53."

reach
"During the early phase of response to a stress signal, USP42 preferentially makes up a complex with and deubiquitinates p53, leading to the rapid activation of p53 for cell cycle arrest and p53-dependent transcription [55]."
| PMC

reach
"P53 can be directly deubiquitinated by Usp42 which reverses its ubiquitination by MDM2 [XREF_BIBR]."

reach
"This is accomplished by several deubiquitination enzymes including USP7 that deubiquitinates Mdm2 to stabilize p53 [XREF_BIBR] as well as USP10 and USP42 that can directly deubiquitinate p53 upon DNA damage [XREF_BIBR, XREF_BIBR]."
USP42 activates TP53.
| 3
USP42 activates TP53. 3 / 3
| 3

reach
"Although we do not find a clear role for USP42 in controlling either the basal or fully activated levels of p53, the function of USP42 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent cell-cycle arrest in response to stress."

reach
"Our previous work showed that USP42 can target p53 for deubiquitylation, with depletion of USP42 resulting in delays in stabilization of p53 and recruitment of p53 to target gene promoters."

reach
"USP42 itself was reported to increase the stability of p53 [XREF_BIBR]."