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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

IRF9 inhibits USP18.

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IRF9 inhibits USP18. 2 / 2

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"Low dose IFNα increases baseline STAT2 and IRF9 expression without strongly activating the negative feedback regulators SOCS1, SOCS3, and USP18, thereby hypersensitizing cells to further interferon stimulation (26)."

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"The same procedure was performed for CRISPR based tagging the additional genes, STAT1, IRF9 and USP18 sequentially.The knockdown of USP18 by shRNA was done using retrovirus transduction."

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IRF9 binds USP18.

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USP18 binds IRF9. 1 / 1

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"The coupled ISGF3-USP18 feedback system revealed in this study may function together with all the other mechanisms to maintain homeostasis in the responses to varying IFN signals."